Crystalline forms, compositions and uses of PCSK9 inhibitors

JP2025527471A5Active Publication Date: 2025-12-23MERCK SHARP & DOHME LLC +1
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Patent Information

Application Number
JP2025508431
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-11-18
Filing Date
2023-08-16
Publication Date
2025-12-23
Estimated Expiration
2043-08-16

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Abstract

The present disclosure provides crystalline forms of compounds of formula (I), as well as pharmaceutically acceptable compositions thereof, methods for their preparation, and their use in methods for treating hypercholesterolemia and other conditions associated with PCSK9 activity (e.g., atherosclerosis, atherosclerotic cardiovascular disease, peripheral artery disease, cerebrovascular disease, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular and cardiometabolic diseases).
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