Novel NLRP3 inflammasome inhibitors

JP2025527640APending Publication Date: 2025-08-22HANGZHOU HIGHLIGHTLL PHARMACEUTICAL CO LTD
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Patent Information

Application Number
JP2025511371
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-08-24
Filing Date
2023-08-18
Publication Date
2025-08-22

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Abstract

The present invention provides compounds of formula (I): [Formula 1] JPEG2025527640000082.jpg40169 wherein all variables are as defined herein and inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in treating diseases and disorders mediated by NLRP3.
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Citation Information

Patent Citations

  • NLRP3 inflammasome inhibitors

    JP2022532354A

  • Pyrolotriazine and imidazotriazine derivatives as regulators of the NLRP3 inflammasome pathway

    JP2025524640A

  • Compounds for inhibiting NLRP3 and uses thereof

    US11319319B1