Herbal extract RM01 and its use and preparation method

The herbal extract RM01, composed of Ophiopogon, wolfberry, and Codonopsis serrata, addresses the limitations of current Alzheimer's treatments by improving cognitive function and reducing β-amyloid plaques, offering a promising therapeutic option for Alzheimer's disease.

JP2025531588APending Publication Date: 2025-09-19RENUMEMO THERAPEUTICS LLC
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Patent Information

Application Number
JP2025541879
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-09-27
Filing Date
2023-09-26
Publication Date
2025-09-19

AI Technical Summary

Technical Problem

Current treatments for Alzheimer's disease only slow its progression without halting it, and there is a need for effective therapies to prevent and ameliorate its symptoms, particularly for individuals with mild cognitive impairment and varying stages of Alzheimer's disease.

Method used

An herbal extract composition, RM01, comprising a mixture of Ophiopogon, wolfberry, Datura stramonium, and Codonopsis serrata, is administered orally to individuals, prepared by heating the mixture in water for 30-60 minutes to collect a liquid extract, which is then used to treat neurodegenerative diseases like Alzheimer's disease.

Benefits of technology

The herbal extract composition RM01 shows potential in improving cognitive function and memory, reducing β-amyloid plaques, and increasing MMSE scores in individuals with Alzheimer's disease, potentially outperforming existing drugs in alleviating symptoms and slowing disease progression.

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Abstract

The present application provides methods for treating patients with neurodegenerative diseases (e.g., Alzheimer's disease) using herbal extract compositions comprising extracts of a mixture containing Ophiopogon japonicus, Barbary Wolfberry, Rhizoma Acori Tatarinowii, and Codonopsis Pilosula. Compositions comprising such extracts and methods for preparing such compositions are also contemplated. In some embodiments according to any of the above-described methods, the disease or condition is Alzheimer's disease (AD).
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