Novel recombinant Fc receptor and cells containing the same

JP2025532928APending Publication Date: 2025-10-03CAROTS CO LTD
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Patent Information

Application Number
JP2025518407
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-09-28
Filing Date
2023-04-06
Publication Date
2025-10-03

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Abstract

The recombinant Fc receptor and cells containing it are resistant to cleavage by ADAM17 due to amino acid modification of the ADAM17 cleavage site of the CD16 polypeptide, and by replacing it with all or part of the extracellular domain of CD64, the binding affinity with the antibody Fc region can be improved.
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Citation Information

Patent Citations

  • Novel, synthetic biology-based adcc technology

    JP2017503510A

  • Polypeptides, cells, and methods involving altered CD16

    JP2017511135A

  • Genetically modified natural killer cells

    JP2020503043A

  • KR2021-0110827