Nucleic acids encoding TGF-beta inhibitors and IL-12 and uses thereof
JP2025536947A5Pending Publication Date: 2026-10-16KALIVIR IMMUNOTHERAPEUTICS INC
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Patent Information
- Application Number
- JP2025522578
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-06-08
- Filing Date
- 2023-10-18
- Publication Date
- 2026-10-16
AI Technical Summary
Technical Problem
Cancer cells overexpress TGF-beta, which evades the host immune response, necessitating compositions and methods to target and modulate TGF-beta activity in the microenvironment.
Method used
A composition comprising nucleic acids encoding IL-12 and TGF-beta inhibitors, delivered via a vaccinia-based vector, enhances anti-tumor immune responses by blocking TGF-beta signaling and promoting IL-12 expression, utilizing CXCR3 ligand-rich tumors for systemic delivery.
Benefits of technology
The combination of IL-12 and TGF-beta inhibitors in the tumor microenvironment improves therapeutic efficacy by reducing immune suppression and enhancing antitumor responses, leading to tumor growth inhibition and increased survival.
✦ Generated by Eureka AI based on patent content.
Abstract
The present disclosure provides nucleic acids encoding transforming growth factor inhibitors and IL-12. Further, nucleic acids encoding the chemokine receptor CXCR3 are provided herein. Additionally, oncolytic viruses comprising the nucleic acids described herein are described herein. The compositions described herein are further described for use in the treatment of cancer. Described herein is a composition comprising a vector, the vector comprising an exogenous nucleic acid comprising a sequence encoding a cytokine or a functional variant thereof, an exogenous nucleic acid comprising a sequence encoding a chemokine receptor or a functional variant thereof, and a first promoter region upstream of the sequence encoding the chemokine receptor, causing expression of the chemokine receptor before expression of the cytokine.
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