Universal CAR-T cells targeting B7H3 and methods for producing and using the same
JP2025538155APending Publication Date: 2025-11-26T MAXIMUM PHARM (SUZHOU) CO LTD
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Patent Information
- Application Number
- JP2025526274
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-11-04
- Filing Date
- 2023-11-03
- Publication Date
- 2025-11-26
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Figure 2025538155000004 
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Abstract
The present application relates to B7H3-binding polypeptides comprising two different anti-B7H3 single domain antibodies. The present application also relates to chimeric antigen receptors comprising the B7H3-binding polypeptides and universal CAR-T cells comprising the chimeric antigen receptors, which recognize tumor cell surface antigens while simultaneously knocking out TCR and HLA-A genes expressed by the cells, thereby reducing immune rejection caused by allogeneic CAR-T therapy, prolonging cell survival, and improving antitumor efficacy.
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