Method for preparing a medicament

The vacuum-assisted method for encapsulating pure API into pharmaceutical carriers addresses loading challenges, ensuring uniformity and homogeneity, facilitating efficient high-throughput manufacturing.

JP2026034702APending Publication Date: 2026-02-27NOVARTIS AG
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Patent Information

Application Number
JP2025265975
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2018-02-01
Filing Date
2025-12-19
Publication Date
2026-02-27

AI Technical Summary

Technical Problem

Existing methods face challenges in achieving consistent and efficient loading of pure active pharmaceutical ingredients (API) into pharmaceutical carriers, particularly at low fill weights, which complicates formulation development and manufacturing processes.

Method used

A method utilizing a vacuum-assisted measuring and filling device, combined with specific powder parameters, to directly encapsulate pure API into pharmaceutical carriers, ensuring compliance with criteria such as Specific Basic Flow Energy (sBFE) and stability index (SI), allowing for high throughput and continuous processing.

Benefits of technology

Enables the production of pharmaceutical products with pure API, reducing formulation time and costs by ensuring uniformity and homogeneity, adaptable to a wide range of powder characteristics, and suitable for high-throughput manufacturing.

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Abstract

To provide an improved method for preparing a pharmaceutical product involving filling an active pharmaceutical ingredient powder into a pharmaceutical carrier using a vacuum-assisted metering and filling device.SOLUTION: The present invention relates to a method for filling a pharmaceutical carrier or dosage form with a pure active pharmaceutical ingredient (API) powder, comprising the steps of dispensing the API powder into a bottom part of the pharmaceutical carrier or dosage form using a vacuum assisted metering and filling device, and covering the bottom part of said pharmaceutical carrier or dosage form with a complementary lid part of said pharmaceutical carrier or dosage form, thereby producing a filled pharmaceutical carrier or dosage form, wherein the filled and sealed pharmaceutical carrier / dosage form typically comprises only the pure API.SELECTED DRAWING: Figure 2
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