Method for producing intercellular lipid-like compositions
A solvent-free method for producing intercellular lipid-like compositions with a multilayer lamellar structure addresses the risks of chloroform and methanol use, ensuring efficient and safe production.
JP2026085979APending Publication Date: 2026-05-26ALBION CO LTD +1
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- ALBION CO LTD
- Filing Date
- 2024-11-14
- Publication Date
- 2026-05-26
AI Technical Summary
Technical Problem
Existing methods for producing intercellular lipids using chloroform and methanol pose risks due to residual solvent issues and lack a viable alternative for forming a lamellar structure without these solvents.
Method used
A method involving dissolution of ceramides, sterol derivatives, and free fatty acids in an alcohol solvent at high temperatures, followed by addition of an aqueous solvent to form a lamellar structure, eliminating the need for chloroform and methanol.
Benefits of technology
This method produces intercellular lipid-like compositions with a multilayer lamellar structure, avoiding hazardous solvents and simplifying the production process while maintaining structural integrity.
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Abstract
This invention provides a method for artificially producing an intercellular lipid-like composition without using chloroform and methanol, and a method for evaluating the function of intercellular lipids in the stratum corneum of the skin using the obtained intercellular lipid-like composition. [Solution] A method for producing an intercellular lipid-like composition having a multilayer lamellar structure, comprising: a dissolution step of dissolving ceramides, sterol derivatives, and free fatty acids in an alcohol solvent to obtain a raw material solution; and an aqueous solvent addition step of adding an aqueous solvent to the raw material solution, wherein the alcohol solvent is an alcohol component of linear or branched monovalent or divalent C2-C2 15 A method in which the solvent mainly contains alcohol, and the temperature of the alcohol solvent during the dissolution process is 40°C or higher.
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