Tetrahydrocurcumin derivatives

Tetrahydrocurcumin derivatives with specific substituents address the low solubility issue, enhancing absorption and safety in oral and aqueous formulations, offering improved therapeutic efficacy for diseases such as neurodegenerative diseases and tumors.

JP2026086079APending Publication Date: 2026-05-26FUKUOKA UNIV
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
FUKUOKA UNIV
Filing Date
2024-11-14
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Tetrahydrocurcumin exhibits low water solubility, leading to poor absorption during oral administration and requiring large amounts of solubilizers, which can be toxic and increase dosage form burden, and its use in aqueous formulations poses risks of anaphylactic shock.

Method used

Development of tetrahydrocurcumin derivatives with specific substituents on phenolic hydroxyl groups to enhance water solubility, allowing for improved absorption and administration in aqueous formulations without the need for solubilizers.

Benefits of technology

The derivatives exhibit excellent water solubility and enhanced absorption, achieving higher plasma levels and effective bioavailability, with improved safety and efficacy in treating conditions like neurodegenerative diseases, tumors, and inflammation.

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Abstract

To provide a tetrahydrocurcumin derivative that is excellent in water solubility and has enhanced absorbability upon oral administration. 【Solution means】A tetrahydrocurcumin derivative represented by formula (1). R 1 and R 2 each independently represents a hydrogen atom or a methoxy group. R 3 and R 4 each independently represents a substituent represented by formula (2a) or (2b) or a hydrogen atom, except when both R 3 and R 4 are hydrogen atoms. In formula (2a), R 5 and R 6 each independently represents an alkyl group having 1 to 3 carbon atoms or a hydrogen atom. TIFF2026086079000008.tif62117
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