Ceramide complex-containing composition

Abstract

To provide a ceramide-containing composition that can improve hair strength, hair flexibility, and hair and skin moisture content. [Solution] A ceramide complex-containing composition comprising a ceramide complex comprising a ceramide, a dihydric alcohol, and an amphoteric surfactant.

Description

Technical Field

[0006] ,

[0001] The present invention relates to a composition containing a ceramide complex.

Background Art

[0002] Ceramide is present in the stratum corneum of the skin and hair, plays an important role in constructing a lipid barrier necessary for moisture retention, and maintaining moisture. There are six different types of ceramides in human skin and hair, each with different functions. In anticipation of the expression of the functions of ceramide, various products containing ceramide have been developed.

[0003] Patent Document 1 describes a ceramide dispersion composition containing ceramide, a polyhydric alcohol, a nonionic surfactant, and an amphoteric surfactant.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, in the ceramide dispersion composition described in Patent Document 1, there is room for improvement in terms of hair strength, hair softness, hair and skin moisture content, etc. An object of the present invention is to provide a composition containing ceramide that can improve hair strength, hair softness, and hair and skin moisture content.

Means for Solving the Problems

[0006] The present invention relates to the following ceramide complex-containing composition. A ceramide complex-containing composition comprising a ceramide complex comprising ceramide, a dihydric alcohol, and an amphoteric surfactant.

Effects of the Invention

[0007] The ceramide complex-containing composition of the present invention can improve hair strength, hair flexibility, and hair and skin moisture content. [Modes for carrying out the invention]

[0008] <Ceramide complex-containing composition> A ceramide complex-containing composition according to an embodiment of the present invention (hereinafter also referred to as "the composition") comprises ceramide, a dihydric alcohol, and an amphoteric surfactant. When ceramide is in a complex state, it can improve hair strength, hair flexibility, and hair and skin moisture content compared to when ceramide is contained alone. This is thought to be because the complex state of ceramide with amphoteric surfactant enhances the adsorption of ceramide to the hair and skin surfaces, and the penetration of amphoteric surfactant into the hair and skin interiors. It is presumed that ceramide forms an ionic complex in the composition. Amphoteric surfactants have both positive and negative ion properties, and ceramide has positive ion properties. In this composition, it is thought that the positive ions of ceramide and the negative ions of the amphoteric surfactant interact ionically to form a complex. In this complex, the positive ions of the amphoteric surfactant do not participate in the interaction with ceramide, so the ceramide complex as a whole has positive ion properties. Here, since the hair and skin surfaces are generally negatively charged, the positively charged ceramide complex is more likely to adsorb to the hair and skin surfaces due to ionic interactions. As a result, the combined amphoteric surfactant penetrates into the hair and skin, and the ceramide ionically combined with the amphoteric surfactant is thought to remain more strongly on the hair and skin surfaces. Therefore, it is thought that improvements in hair strength, hair flexibility, and hair and skin moisture content can be obtained compared to when ceramide is contained alone.

[0009] One reason why the ceramide dispersion composition described in Patent Document 1 does not produce the effects such as hair strength as in the present invention is that, according to the method of producing the composition described in Patent Document 1, the ceramide does not form a complex in the composition. As will be described later, in order for ceramide to form a complex in the composition according to the present invention, it is preferable not to add water when dispersing ceramide in a dihydric alcohol. Patent Document 1 describes that a ceramide dispersion composition can be obtained by mixing an aqueous phase component containing a polyhydric alcohol with an oil phase component containing ceramide. Furthermore, another reason why the ceramide dispersion composition described in Patent Document 1 does not produce the same effects as the present invention is thought to be that the polyhydric alcohol substantially used in Patent Document 1 is glycerin, i.e., a trihydric alcohol. In contrast, the present composition uses a dihydric alcohol, which allows for better penetration of the amphoteric surfactant into the hair and skin than a trihydric alcohol. This is presumed to be because using a dihydric alcohol results in higher dispersibility of ceramide and amphoteric surfactant than using a trihydric alcohol, allowing for the formation of an optimal complex.

[0010] In this composition, ceramides with a naturally derived structure are preferred. Ceramides with a naturally derived structure may be extracted from nature, or obtained by fermentation and / or synthesis. Examples of naturally derived ceramides include ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6B, and ceramide 7, which differ in the structure of sphingosine and long-chain fatty acids. Two or more of these may be used in mixtures. Of these, ceramide 1, ceramide 2, ceramide 3, ceramide 5, and ceramide 6B are preferred from the viewpoint of availability, and ceramide 2 and ceramide 3, which are known to be the main components of ceramide in hair, are more preferred, with ceramide 2 being the most preferred. Commercially available ceramides may also be used.

[0011] Examples of dihydric alcohols in this composition include propylene glycol, 1,3-propanediol, dipropylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, 1,2-pentanediol, 1,5-pentanediol, isoprene glycol, hexylene glycol, 1,2-hexanediol, and 1,6-hexanediol. Two or more of these may be used in combination. Of these, dipropylene glycol is particularly preferred from the viewpoint of usability and dispersibility.

[0012] Examples of amphoteric surfactants in this composition include glycine-type amphoteric surfactants, betaine-type amphoteric surfactants, amine oxide-type amphoteric surfactants, lecithins, and the like. Examples of glycine-type amphoteric surfactants include sodium cocoamphoacetate, sodium lauroamphoacetate, and sodium cocanphodiacetate. Examples of betaine-type amphoteric surfactants include aminoacetic acid betaine-type surfactants and sulfobetaine-type surfactants. Examples of aminoacetic acid betaine-type surfactants include cocamidopropyl betaine, lauramidopropyl betaine, myristamidopropyl betaine, palm kernel fatty acid amidopropyl betaine, lauryl betaine, and cocobetaine. Examples of sulfobetaine-type surfactants include lauryl hydroxysultaine, lauramidopropyl hydroxysultaine, and cocamidopropyl hydroxysultaine. Examples of amine oxide-type amphoteric surfactants include lauramine oxide and lauramidopropylamine oxide. Examples of lecithins include lecithin, lysolecithin, hydrogenated lecithin, and hydrogenated lysolecithin. Two or more amphoteric surfactants may be used in combination. Of these, betaine-type surfactants are preferred from the viewpoint of usability and irritation, aminoacetic acid betaine-type surfactants and sulfobetaine-type surfactants are more preferred, and cocamidopropyl betaine is particularly preferred.

[0013] In this composition, the ratio of ceramide to amphoteric surfactant is preferably 6:1 to 1:6 in molar ratio, more preferably 5:1 to 1:5, particularly preferably 3:1 to 1:3, and most preferably 1:1. Having the molar ratio of ceramide to amphoteric surfactant within this range is preferable because it results in less residue that does not form complexes, and allows for effective adsorption and penetration.

[0014] In this composition, the proportion of dihydric alcohol is preferably 80% to 99% by mass, more preferably 85% to 95% by mass, and particularly preferably 88% to 92% by mass. Having the proportion of dihydric alcohol within this range is effective and preferable in terms of dispersibility and stability.

[0015] In this composition, the ceramide, the dihydric alcohol, and the amphoteric surfactant are thought to form a complex as described above. More specifically, it is thought that the ceramide and the amphoteric surfactant are dispersed in the viscous liquid dihydric alcohol, mainly through ionic interactions, forming a complex. Furthermore, since particles with a particle size of 10 to 100 μm have been confirmed by polarized light observation and light scattering measurements of this composition under a microscope, the size of the complex is estimated to be approximately 10 to 100 μm. It is presumed that by including such a complex in this composition, the ceramide becomes more easily dispersed, making it easier to disperse when incorporated into cosmetics, and improving its adsorption to the surface of hair and skin.

[0016] The ceramide complex in this composition may contain other components besides the ceramide, dihydric alcohol, and amphoteric surfactant mentioned above. Examples of other components include cationic surfactants, anionic surfactants, nonionic surfactants, cationic polymers, anionic polymers, and nonionic polymers. The proportion of other components is preferably 0.01 to 5% by mass.

[0017] This composition may contain components other than the ceramide complex, as long as it does not deviate from the effects of the present invention. For example, residual ceramides not involved in the ceramide complex, amphoteric surfactants, and dihydric alcohols can be mentioned. Moreover, it may contain preservatives, antioxidants, bactericides, chelating agents, and the like.

[0018] From the viewpoint that the ceramide complex is likely to be formed, the water content of this composition is preferably 10% by mass or less, more preferably 5% by mass or less.

[0019] This composition can be obtained by dispersing ceramides and amphoteric surfactants in a dihydric alcohol. The ceramides and amphoteric surfactants may be dispersed simultaneously, or either one may be dispersed first and the other later. Here, when dispersing ceramides in a dihydric alcohol, it is preferable to use ceramides in a solid state and disperse them without adding water. This makes it easier to form a ceramide complex. When water is present during the dispersion of ceramides, it is difficult to form a ceramide complex. The amphoteric surfactant may be in a solid state or an aqueous solution state. When using it in an aqueous solution state, it is preferably mixed after dispersing ceramides in a dihydric alcohol, and it is further preferable to remove water after mixing.

[0020] When dispersing ceramides, it is preferably heated to 85°C to 100°C, more preferably 90°C to 95°C, from the viewpoint of enhancing dispersibility.

[0021] <Cosmetics> This ceramide complex-containing composition is effective in improving the permeability of ceramides into hair and skin, hair strength, hair softness, and the water content of hair and skin, and thus can be formulated into various cosmetics. In the cosmetics of this embodiment, the content of this ceramide complex-containing composition can be selected according to the type of cosmetics, preferably 0.00001 to 10% by mass, more preferably 0.0001 to 1% by mass, and most preferably 0.001 to 0.1% by mass.

[0022] Cosmetics may contain, as needed, additives commonly found in cosmetics, such as oily bases, moisturizers, texture enhancers, surfactants, polymers, thickeners / gelling agents, solvents, propellants, antioxidants, reducing agents, oxidizing agents, antibacterial agents, preservatives, chelating agents, pH adjusters, acids, alkalis, powders, inorganic salts, UV absorbers, whitening agents, vitamins and their derivatives, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoters, irritation relievers, analgesics, cell activators, plant / animal / microbial extracts, antipruritics, exfoliating / dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, fragrances, pigments, colorants, dyes, pigments, water, etc.

[0023] As oily bases, higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachidodecanol, behenyl alcohol, jojoba alcohol, chymyl alcohol, cerachidodecanol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimergol, etc.; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenyl alcohol Higher fatty acids such as chlorophobic acid, undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanic acid, long-chain branched fatty acids, dimer acids, hydrogenated dimer acids, and other higher fatty acids, as well as metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, and sodium salts thereof, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin Hydrocarbons such as in-oligomers, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, and solid paraffin; waxes such as candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, and castor oil. Vegetable oils such as shea butter, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, peach kernel oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, etc.; animal fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil, etc.; animal waxes such as whale wax, lanolin, orange roughy oil, etc.Lanolin derivatives such as liquid lanolin, reduced lanolin, adsorbed and purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate alcohol, and (cetyl lanolyl) acetate; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin and other sphingophospholipids, phosphatidic acid, lysolecithin and other phospholipids; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid and other phospholipid derivatives; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid and other sterols; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, Cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), acylsalcosinate isopropyl, etc. Sterol esters such as cosine alkyl esters, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid-cholesterol complexes and phospholipid-phytosterol complexes;Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palimitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolate, hexyldecyl dimethyloctanoate Monoalcoholic carboxylic acid esters such as octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolinate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyl octyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate, etc.; oxyacid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, etc.;Glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, caprylic / capric triglyceride, caprylic / capric / myristic / stearic triglyceride, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eicosanedioate behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycoside dioctanoate Neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, (isostearate / sebacate) ditrimethylolpropane, pentaerythrityl triethylhexanoate, (hydroxystearate / stearate / rosinate) dipentaerythrityl, diglyceryl diisostearate, tetraiso Polyglyceryl stearate, polyglyceryl-10 nonaisostearate, polyglyceryl-8 dec(erucic acid / isostearate / ricinoleic acid), diglyceryl oligoesters (hexyldecanoic acid / sebacic acid), glycol distearate (ethylene glycol distearate), polyhydric alcohol fatty acid esters such as 3-methyl-1,5-pentanediol dieopentanoate and 2,4-diethyl-1,5-pentanediol dieopentanoate; diisopropyl dimer dilinoleate, dimer dilinoleate Diomer acids or dimer ol derivatives such as diisostearyl dimer dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, (phytosteryl / behenyl) dimer dilinoleate, (phytosteryl / isostearyl / cetyl / stearyl / behenyl) dimer dilinoleate, dimer dilinoleyl diisostearate, hydrogenated rosin condensate of dimer dilinoleate, hydrogenated castor oil of dimer dilinoleate, and hydroxyalkyl dimer dilinoleyl ethers;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, stearoxypropyl dimethylamine, (aminoethylaminopropyl methicone / dimethicone) copolymer, dimethicone Silicones such as thiconol, dimethiconol crosspolymer, silicone resins, silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cationic-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphate-modified silicones, sulfuric acid-modified silicones, alkyl-modified silicones, fatty acid-modified silicones, alkyl ether-modified silicones, amino acid-modified silicones, peptide-modified silicones, fluorine-modified silicones, cationic-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, and polysiloxane-oxyalkylene copolymers are preferred; fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether are also preferred.

[0024] As moisturizers and texture enhancers, polyols and their polymers such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol / propylene glycol copolymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; sorbitol, xylitol, erythritol, mannitol, etc. Sugar alcohols such as lutitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrins, and modified cyclodextrins such as maltosylated and hydroxyalkylated cyclodextrins), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin Sugars and their derivatives such as trin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, kerato sulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salt and other salts;Amino acids such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, and their salts; collagen, fish collagen, atelocollagen, gelatin, elastin, collagen-degraded peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degraded peptides, keratin-degraded peptides, hydrolyzed keratin, conchiolin-degraded peptides, hydrolyzed conchiolin, silk protein-degraded peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein-degraded peptides, wheat protein-degraded peptides, hydrolyzed wheat protein, casey Preferred materials include protein peptides such as degraded peptides and acylated peptides and their derivatives; acylated peptides such as palmitoyl oligopeptides, palmitoyl pentapeptides, and palmitoyl tetrapeptides; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesamin glycosides, glutathione, albumin, and whey; choline chloride and phosphorylcholine; placental extract, aerlastin, collagen, aloe extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rose extract, yarrow extract, eucalyptus extract, and sweet clover extract; and ceramides such as natural ceramides (types 1, 2, 3, 4, 5, 6, and 7), hydroxyceramides, pseudoceramides, sphingoglycolipids, ceramides, and glycoceramide-containing extracts. ;

[0025] Preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymeric surfactants. There are no particular restrictions on the HLB of the surfactant; those with a low HLB of around 1 to a high HLB of around 20 can be used, and it is also preferable to combine those with low and high HLB values. Examples of preferred surfactants include anionic surfactants such as fatty acid salts like potassium laurate and potassium myristate; alkyl sulfate esters such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methylalanine, sodium lauroyl sarcosinate, triethanolamine lauroyl sarcosinate, and sodium lauroyl glutamate methylalanine; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, and palmitoyl glutamate. Acyl amino acid salts such as ditriethanolamine aspartate and triethanolamine cocoyl alanine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinate ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty acid amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; alkylbenzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and sodium dioctyl sulfosuccinate; alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate sodium, and sodium lauryl polypropylene glycol sulfosuccinate sodium;Alkylbenzenesulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalene sulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, and sodium monooleth phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphates; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicones, phosphate-modified silicones, and sulfate-modified silicones; nonionic surfactants include laureth (polyoxyethylene lauryl ether) and ceteth (polyoxyethylene lauryl ether). Polyoxyethylene alkyl ethers of various polyoxyethylene addition numbers, such as polyoxyethylene cetyl ethers, steareths (polyoxyethylene stearyl ethers), beheneths (polyoxyethylene behenyl ethers), isosteareths (polyoxyethylene isostearyl ethers), and octyldodeceths (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkylphenyl ethers; castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, and polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin;Polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl. ) Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, coconut oil fatty acid glyceryl, monocottonseed oil fatty acid glycerin, monoerucate glycerin, sesquioleate glycerin, α,α'-oleate pyroglutamate glycerin, monostearate glycerin malic acid and other glycerin fatty acid partial esters; polyglyceryl-2, 3, 4, 5, 6, 8 stearate , same 10, polyglyceryl-6 distearate, same 10, polyglyceryl-2 tristearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 isostearate, same 3, same 4, same 5, same 6, same 8, same 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), same 3, same 10, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, same 3, Polyglycerin fatty acid esters such as Polyglyceryl-6 dioleate, Polyglyceryl-2 trioleate, Polyglyceryl-10 decaoleate; Ethylene glycol monofatty acid esters such as Ethylene glycol monostearate; Propylene glycol monofatty acid esters such as Propylene glycol monostearate; Pentaerythritol partial fatty acid ester; Sorbitol partial fatty acid ester; Maltitol partial fatty acid ester; Maltitol ether;Sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, sorbitan penta-2-ethylhexyl diglycerol sorbitan, sorbitan tetra-2-ethylhexyl diglycerol sorbitan; sugar derivative partial esters such as sucrose fatty acid esters, methyl glucoside fatty acid esters, and trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycerides Coside; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acid mono and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene glycerin fats such as polyoxyethylene monooleate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate, and other polyoxyethylene monooleates. Fatty acid esters; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chymyl alcohol, cerakyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); lauramine oxide, Alkyldimethylamine oxides such as cocamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, sugar-modified silicones, and other silicone-based nonionic surfactants; cationic surfactants such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride. Alkyltrimethylammonium chlorides such as ammonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amide amines and their salts such as stearamidopropyldimethylamine and stearamidoethyldiethylamine; alkyl etheramines and their salts or quaternary salts such as stearoxypropyldimethylamine; fatty acid amide-type quaternary ammonium salts such as ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium and ethyl sulfate lanolin fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and their salts or quaternary salts; alkylamine salts; fatty acid amide guanidium salts; alkyl etheramine mononium salts; alkyl trialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmolyphonium salts; polyamine fatty acid derivatives;Silicone-based cationic surfactants such as aminopropyl dimethicone and amodimethicone (amino-modified silicones), cationic-modified silicones, cationic and polyether-modified silicones, amino-modified and polyether-modified silicones, etc.; amphoteric surfactants such as N-alkyl-N,N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N,N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyl sulfobetaines such as alkyldimethyl taurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; sphingolines such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin; Phospholipids such as lipids, lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, and hydroxylated lecithin; silicone-based amphoteric surfactants; and polymeric surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, and acrylic acid / alkyl methacrylate copolymers; and various silicone-based surfactants are preferred.

[0026] Examples of polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed gum, carrageenan, galactan, gum arabic, tara gum, tamarind, fercerelan, karaya gum, okra gum, tragacanth gum, pectin, pectic acid and its salts, alginic acid and its salts, mannan; starches from rice, corn, potato, wheat, etc.; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin, chitosan. Agar, cassia seed extract, chondroitin sulfate, casein, collagen, gelatin, albumin; cellulose and its derivatives such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch, etc. Starch derivatives such as hydroxypropyltrimonium chloride starch, corn starch aluminum octenyl succinate; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate ester copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester;Polyacrylamide; polyacrylic acid ester copolymers such as ethyl polyacrylate, carboxyvinyl polymers, salts such as polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymers; acrylic acid / alkyl methacrylate copolymers; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymers such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymers such as polyquaternium-22, acrylic acid / diallyldimethylammonium chloride / acrylamide copolymers such as polyquaternium-39, acrylic acid / cationized methacrylic acid ester copolymers, acrylic acid / cationized methacrylamide copolymers, acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymers such as polyquaternium-47, choline methacrylate ester polymers; cationized oligosaccharides, cationized dextran, cationized guar hydroxypropyltrimonium chloride, etc. Polysaccharides; polyethyleneimines; cationic polymers; copolymers of 2-methacryloyloxyethyl phosphorylcholine polymers such as polyquaternium-51 and butyl methacrylate copolymers; polymer emulsions such as acrylic resin emulsions, ethyl polyacrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; anhydrous silicic acid, fuzzy silica (ultrafine particle anhydrous silicic acid), magnesium aluminum silicate, magnesium sodium silicate, metal soaps, dialkyl phosphate metal salts, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters are among the preferred materials.

[0027] Solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and di Preferred propellants include glycol ethers such as propylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation chlorofluorocarbons; LPG, dimethyl ether, and carbon dioxide.

[0028] Preferred antioxidants include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine ​​hydrochloride. Preferred reducing agents include thioglycolic acid, cysteine, and cysteamine. Preferred oxidizing agents include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

[0029] As antibacterial or preservative agents, parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; alkylglyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzalkonium chloride Preferred agents include zethonium, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenols, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol, and other phenols; phenylethyl alcohol, photosensitizers, antimicrobial zeolites, and silver ions. However, when used as an antimicrobial agent or preservative for preservation purposes, from the viewpoint of safety for cosmetics or topical skin preparations, it is more preferable to use phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; and alkylglyceryl ethers such as 2-ethylhexylglyceryl ether.

[0030] Preferred chelating agents include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and their sodium salts; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid. Preferred pH adjusters, acids, and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

[0031] Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium dioxide, fine and ultrafine titanium dioxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fuzzy silica (ultrafine anhydrous silicic acid), and titanium mica. Preferred materials include inorganic powders of various sizes and shapes such as fish scale foil, boron nitride, photochromic pigments, synthetic fluorphlogopite, fine particle composite powders, gold, aluminum, and inorganic powders that have been hydrophobized or hydrophilized by treating them with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silanes or titanium coupling agents; organic powders of various sizes and shapes such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminated powder, polyethylene terephthalate-aluminum-epoxy laminated powder, urethane powder, silicone powder, Teflon® powder, and other organic powders and surface-treated powders, as well as organic-inorganic composite powders.Preferred inorganic salts include sodium chloride-containing salts such as table salt, regular salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate; and sodium phosphates such as 1Na, 2Na, and 3Na phosphates, potassium phosphates, calcium phosphates, and magnesium phosphates.

[0032] UV absorbers include benzoic acid-based UV absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerol ester, N,N-dipropoxypara-aminobenzoate ethyl ester, N,N-diethoxypara-aminobenzoate ethyl ester, N,N-dimethylpara-aminobenzoate ethyl ester, N,N-dimethylpara-aminobenzoate butyl ester, and N,N-dimethylpara-aminobenzoate ethyl ester; anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid-based UV absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanolphenyl salicylate; and octyl cinnamate. Cinnamic acid-based UV absorbers such as ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy cinnamate, 2-ethylhexyl-p-methoxy cinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxy cinnamate (cinoxate), cyclohexyl-p-methoxy cinnamate, ethyl-α-cyano-β-phenyl cinnamate, 2-ethylhexyl-α-cyano-β-phenyl cinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy cinnamate, ferulic acid and its derivatives;Benzophenone-based UV absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenylbenzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydro Xy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzarazine; dianisioylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butyl methoxydibenzoylmethane; octyltriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanic acid; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole; Preferred materials include benzotriazole (nyl), 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, and other hydantoin derivatives, phenylbenzimidazol sulfonic acid, terephthalylidene dicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.

[0033] Preferred whitening agents include hydroquinone glycosides and their esters such as arbutin and α-arbutin; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbic acid phosphate ester and magnesium ascorbic acid phosphate ester; ascorbic acid fatty acid esters such as tetraisopalmitic ascorbic acid; alkyl ascorbic acid ethers such as ethyl ascorbic acid; ascorbic acid glucosides and their fatty acid esters such as ascorbic acid-2-glucoside; ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives; placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, willow extract, saxifrage extract, and other plant extracts.

[0034] Vitamins and their derivatives include vitamin A compounds such as retinol, retinyl acetate, and retinyl palmitate; vitamin B compounds such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acid compounds, nicotinic acid compounds such as nicotinamide and benzyl nicotinate, and choline compounds; vitamin C compounds such as ascorbic acid and its sodium salts; vitamin D; vitamin E compounds such as α, β, γ, and δ-tocopherols; other vitamins such as pantothenic acid and biotin; and ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt. Preferred materials include ascorbic acid phosphate salts, ascorbic acid fatty acid esters such as tetraisopalmitic ascorbate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, alkyl ascorbic acid ethers such as ethyl ascorbate, ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate esters, tocotrienols, and various other vitamin derivatives.

[0035] Preferred anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract. Preferred hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, Capsicum tincture, Ginger tincture, Ginger extract, and Cantharis tincture; capsaicin, nonylic acid valenylamide, gingerol, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E and derivatives such as tocopherol nicotinate and tocopherol acetate; γ-oryzanol, nicotinic acid and derivatives such as nicotinamide, benzyl nicotinate, inositol hexanicotinate, and nicotinic alcohol; allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmamanol and its glycosides; and minoxidil. Preferred hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, and prednisone.Other medicinal agents such as anti-wrinkle agents, anti-aging agents, firming agents, cooling agents, warming agents, wound healing promoters, irritation relievers, analgesics, and cell activators include retinols, retinoic acids, retinoic acid tocopheryl; lactic acid, glycolic acid, gluconic acid, fruit acids, salicylic acid and its glycosides and esters and their derivatives; hydroxycapric acid, long-chain α-hydroxy fatty acids, long-chain α-hydroxy fatty acid cholesteryl and other α- or β-hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosine; caffeine, xanthine and its derivatives; coenzyme Q10, carotene, lycopene, astaxanthin, lutein, α-lipoic acid, platinum nanoparticles Antioxidants and free radical scavengers such as loids and fullerenes; catechins; flavonoids such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannins, sesamin, protoanthocyanidins, chlorogenic acid, and apple polyphenols; derivatives of rutin and glycosides; derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; lactoferrin; gingerol; fragrance substances and their derivatives such as menthol, camphor, and cedrol; capsaicin, vanillin, and their derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances with cyclodextrins are preferred.

[0036] Plant, animal, and microbial extracts include iris extract, angelica extract, Thujopsis dolabrata extract, asparagus extract, avocado extract, Hydrangea macrophylla extract, almond extract, marshmallow extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, fig extract, fennel extract, turmeric extract, oolong tea extract, bearberry extract, rosehip extract, Echinacea leaf extract, Enmeisou extract, scutellaria extract, phellodendron bark extract, Coptis japonica extract, barley extract, ginseng extract, St. John's wort extract, and dwarf cinnamon extract. Kosou extract, Ononis extract, Nasturtium officinale extract, Orange extract, Dried seawater, Seaweed extract, Persimmon leaf extract, Kakyo extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria lobata extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Artemisia capillaris extract, Oat extract, Chloranthus erythrosora extract, Licorice extract, Oil-soluble licorice extract, Kiwi extract, Kiummer extract, Wood ear mushroom extract, Cinchona extract, Cucumber extract, Paulownia leaf extract, Guanosine, Guava extract, Sophora flavescens extract, Gardenia extract, Sasa veitchii extract Sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Geranium thunbergii extract, black tea extract, yeast extract, Magnolia bark extract, coffee extract, burdock extract, rice extract, rice fermentation extract, rice bran fermentation extract, rice germ oil, comfrey extract, collagen, lingonberry extract, Asarum sieboldii extract, Bupleurum chinense extract, umbilical cord extract, saffron extract, sage extract, soapwort extract, bamboo extract, hawthorn extract, sunflower extract Sodium, Japanese pepper extract, shiitake mushroom extract, rehmannia extract, lithospermum extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony extract, ginger extract, calamus root extract, birch extract, white fungus extract, horsetail extract, stevia extract, stevia ferment, iris extract, ivy extract, hawthorn extract, elderflower extract, yarrow extract, peppermint extract, sage extract, mallow extract, chuanxiong extract, swertia japonica extract, mulberry bark extract, rhubarb extract,Soybean extract, jujube extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, cogongrass extract, citrus peel extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, Ophiopogon extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, Isodon japonicus extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur extract, Poria cocos extract, butcher's broom extract, grape extract, grape seed extract Preferred extracts include those of kiss, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, cypress extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, lemon balm extract, seaweed extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, reishi mushroom extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and Sanguisorba officinalis extract.

[0037] Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance-P inhibitors. Examples of exfoliating and dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, and pyridoxine. Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of cooling agents include menthol and methyl salicylate. Examples of astringent agents include citric acid, tartaric acid, lactic acid, potassium aluminum sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease. Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

[0038] The fragrance ingredients include acetylcedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, iso-esuper, isobutylquinoline, iris oil, ylone, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragol, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carbone, camphor, canone, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styraryl acetate, cedyl acetate, terepinel acetate, and pt-butylcyclohexyl acetate. Lu, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanol, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-Nonadienol, Nonalactone, Patchouli Alcohol, Vanilla Absolute, Vanillin, Basil Oil, Patchouli Oil, Hydroxycitronellal, α-Pinene, Piperitone, Phenethyl Alcohol, Phenylacetaldehyde, Petitgrain Oil, Hexyl Cinnamaldehyde, cis-3-Hexenol, Peruvian Balsam, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Benzyl Benzoate Preferred examples include synthetic and natural fragrances such as benzoate, borneol, myrrhizinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, liral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances.

[0039] As pigments, colorants, dyes, and dyes, they include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, and Red. Color No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 22 No. 5, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red Color No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Legal dyes such as Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202-1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow 407, Yellow 5, etc.; Acid Other acid dyes such as Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; nitro dyes such as HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, and Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and lower titanium oxide; inorganic purple pigments such as mango violet and cobalt violet;Inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium dioxide-coated mica, titanium dioxide-coated bismuth oxychloride, titanium dioxide-coated talc, colored titanium dioxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; surface-treated inorganic and metal powder pigments; Red 201 Zirconium, including Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1, etc. Organic pigments such as barium or aluminum lake; surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin, naphthoquinones, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, rutin, and other natural pigments and dyes; oxidative dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-,m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and their salts; auto-oxidative dyes such as indoline; dihydroxyacetone is preferred.

[0040] In addition to tap water and purified water, preferred types of water include hard water, soft water, natural water, deep-sea water, electrolyzed alkaline ionized water, electrolyzed acidic ionized water, ionized water, and clustered water.

[0041] In addition to these, it is possible to include known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., in known combinations, formulation ratios, and amounts, such as ingredients listed in the Cosmetic Raw Material Standards, Cosmetic Ingredient Formulation Standards, Japan Cosmetic Industry Association Ingredient Labeling Name List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Raw Material Standards, Japanese Pharmacopoeia, Pharmaceutical Additives Standards, Food Additives Compendium, etc., as well as ingredients listed in Japanese and foreign patent gazettes and patent publications (including published and republished gazettes) belonging to the International Patent Classification IPC A61K7 and A61K8 classifications.

[0042] Preferred types of cosmetics containing the ceramide complex-containing composition of the present invention include hair cosmetics, basic cosmetics, makeup cosmetics, fragrance cosmetics, body cosmetics, and topical skin preparations such as ointments. The cosmetics of the present invention can be manufactured according to conventional methods.

[0043] To further describe in detail the types of cosmetics containing the ceramide complex-containing composition of the present invention, preferred hair cosmetics include shampoos such as oil shampoos, cream shampoos, conditioning shampoos, anti-dandruff shampoos, hair color shampoos, and rinse-integrated shampoos; rinses, treatments, hair packs, hair foams, hair mousses, hair sprays, hair mists, hair waxes, hair gels, water greases, setting lotions, color lotions, hair tonics, hair liquids, pomades, hair sticks, hair creams, hair blowers, split end coats, hair oils, permanent wave agents, straightening perm agents, oxidative hair dyes, hair bleaches, hair color pre-treatments, hair color after-treatments, perm pre-treatments, perm after-treatments, hair manicures, and hair growth agents.

[0044] Basic cosmetics include lotions such as softening lotions, astringent lotions, cleansing lotions, and multi-layer lotions; emulsions such as emollient lotions, moisturizing lotions, milky lotions, nourishing lotions, nourishing milks, skin moisturizers, moisturizing emulsions, massage lotions, cleansing lotions, protective emulsions, sun protectors, UV care milks, sunscreens, makeup lotions, exfoliating smoothers, elbow lotions, hand lotions, and body lotions; and emulsions such as emollient creams, nourishing creams, vanishing creams, moisturizing creams, night creams, massage creams, cleansing creams, makeup creams, base creams, and pre-makeup creams. Preferred products include creams such as sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, and exfoliating cream; gels such as moisturizing gel; essences such as moisturizing essence, whitening essence, and UV protection essence; liposome cosmetics such as liposome serum and liposome lotion; packs and masks such as peel-off packs, powder packs, washing packs, oil packs, and cleansing masks; facial cleansers such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, washing powder, and face washing powder; and soaps such as cosmetic soap, clear soap, medicated soap, liquid soap, shaving soap, and synthetic cosmetic soap.

[0045] Preferred makeup products include face powders, powders, foundations, lipsticks, lip glosses, blushes, eyeliners, mascaras, eyeshadows, eyebrow pencils, eyebrow products, nail polish, nail polish removers, and nail treatments.

[0046] Preferred fragranced cosmetics include perfumes, fragrances, parfums, eau de parfums, eau de toilettes, eau de colognes, solid perfumes, fragrance powders, fragranced soaps, body lotions, and bath oils.

[0047] Preferred body cosmetics include body washes such as body shampoos; deodorants such as deodorant lotions, deodorant powders, deodorant sprays, and deodorant sticks; bleaching agents, hair removal agents; bath additives; and insect repellents such as insect repellent sprays.

[0048] Furthermore, it can be used as a topical skin preparation in various forms such as ointments, patches, lotions, liniments, and liquid preparations. It can also be used as an oral cosmetic, such as toothpaste or mouthwash.

[0049] Preferred dosage forms for cosmetics containing the ceramide complex-containing composition of the present invention include emulsified cosmetics such as oil-in-water (O / W) type, water-in-oil (W / O) type, water-in-oil (W / O) type, O / W / O type, oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, paste cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

[0050] Cosmetics containing the ceramide complex-containing composition of the present invention can be manufactured by mixing the ceramide complex-containing composition with necessary components according to the desired cosmetic composition. In this case, it is preferable to heat the ceramide complex-containing composition or mix it with an appropriate dispersion medium before incorporating it into the cosmetic composition in order to improve the dispersibility of the ceramide complex.

[0051] As stated above, this specification contains the following information: [1] A ceramide complex-containing composition comprising a ceramide complex comprising a ceramide, a dihydric alcohol, and an amphoteric surfactant. [2] The ceramide complex-containing composition according to [1], wherein the molar ratio of the ceramide to the amphoteric surfactant is 5:1 to 1:5. [3] The ceramide complex-containing composition according to [1] or [2], wherein the ceramide is a ceramide with a naturally derived structure. [4] A ceramide complex-containing composition according to any one of [1] to [3], wherein the ceramide comprises one or more selected from ceramide 1, ceramide 2, ceramide 3, ceramide 5, and ceramide 6B. [5] The ceramide complex-containing composition according to any one of [1] to [4], wherein the dihydric alcohol comprises one or more selected from isoprene glycol, propylene glycol, 2,3-butylene glycol, 1,3-butylene glycol, and dipropylene glycol. [6] The ceramide complex-containing composition according to any one of [1] to [5], wherein the amphoteric surfactant is a betaine-type surfactant. [7] The ceramide complex-containing composition according to any one of [1] to [6], wherein the amphoteric surfactant comprises at least one of an aminoacetic acid betaine type surfactant and a sulfobetaine type surfactant. A cosmetic comprising a ceramide complex-containing composition described in any one of [8], [1], to [7]. [Examples]

[0052] The present invention will be described in more detail below using examples, but the present invention is not limited to these.

[0053] (Ceramide) Ceramide 2 (Ceramide NG): Manufactured by Takasago International Corporation, product name CERAMIDE TIC-001 Ceramide 1 (Ceramide EOP): Manufactured by Evonik Japan, product name CERAMIDE I Ceramide 3 (Ceramide NP): Manufactured by Evonik Japan, product name CERAMIDE III Ceramide 5 (Ceramide AS): Manufactured by Takasago International Corporation, product name CERAMIDE TIC-006 Ceramide 6B (Ceramide AP): Manufactured by Evonik Japan, product name CERAMIDE VI (Amphoteric surfactant) Cocamidopropyl betaine (30% by mass aqueous solution): Manufactured by Clariant, trade name Genagen CABJ Sodium cocoamphoacetate: Manufactured by Toho Chemical Industry Co., Ltd., product name: Obazolin 662N Lauryl betaine: Manufactured by NOF Corporation, product name: Nissan Anon BL Lauramidopropyl betaine: Manufactured by NOF Corporation, product name: Nissan Anon BDL-SF Lauryl hydroxysultaine: Manufactured by Kao Chemical Co., Ltd., product name: Anchitol 20HD

[0054] (Example 1) Dipropylene glycol was mixed with ceramide 2 and heated at 85-100°C to disperse the mixture. Then, a 30% by mass aqueous solution of cocamidopropyl betaine was mixed in, and the water was removed using an evaporator to obtain a ceramide complex-containing composition. The amounts of ceramide 2, cocamidopropyl betaine, and dipropylene glycol were adjusted to the proportions shown in Table 1 based on solid content.

[0055] (Examples 2-9) A ceramide complex-containing composition was obtained in the same manner as in Example 1, except that the ratios of ceramide 2 and cocamidopropyl betaine were as shown in Table 1.

[0056] (Comparative Example 1) A composition was obtained in the same manner as in Example 1, except that it did not contain cocamidopropyl betaine.

[0057] (Comparative Example 2) A composition was obtained in the same manner as in Example 1, except that it did not contain ceramide 2.

[0058] (Comparative Example 3) A composition was obtained in the same manner as in Example 1, except that it did not contain cocamidopropyl betaine and ceramide 2.

[0059] <Rating> The compositions were evaluated under the conditions shown below.

[0060] (Dispersibility of ceramide complexes) The dispersibility of the ceramide complex in the composition was evaluated visually. The evaluation criteria were as follows, and a score of A or B was considered a passing grade. A: At temperatures above 85°C, it is uniformly dispersed and transparent. B: At temperatures above 85°C, it is generally dispersed, but precipitates are observed. At temperatures above 85°C, the substance is hardly dispersed, and precipitates are observed. D: At temperatures above 85°C, it is almost completely dispersible and in solid form.

[0061] (Finished texture of hair) 0.5g of each composition obtained above was applied to hair strands and wigs (manufactured by Beaulux Co., Ltd.) that had been damaged by bleaching. After 60 minutes, the mixture was rinsed with water and dried, and the texture of the finished hair was evaluated by five panelists. The evaluation criteria were as follows, and a grade of A to C was considered a passing grade. A: 5 out of 5 people felt the effect was significantly greater compared to untreated hair strands and wigs. B: Compared to untreated hair strands and wigs, 4 out of 5 people felt the effect was significantly greater. C: Three out of five people felt the effect was significantly greater compared to untreated hair strands and wigs. D: Two out of five people felt that there was a statistically significant difference compared to untreated hair strands and wigs.

[0062] (Penetration effect of cocamidopropyl betaine (amphoteric surfactant) into the hair and skin) Hair strands damaged by bleaching (manufactured by Beaulux Co., Ltd.) were coated with 0.5g of each composition obtained above. After 60 minutes, the hair was rinsed with water and dried. The penetration of cocamidopropyl betaine into the hair was then visualized by observing the hair cross-section using a mass imaging microscope. Each of the compositions obtained above (50 μL) was applied to a 3D skin model, and after 15 minutes, the mixture was washed off. This process was repeated. The samples were cultured for 7 days and observed using a mass imaging microscope to visualize the penetration of cocamidopropyl betaine into the 3D skin. The evaluation criteria for the inside of the hair were as follows, and a score of A to C was considered a passing grade. A: The penetration effect is significantly greater compared to untreated hair strands (penetrating to 100% of the hair's cross-sectional area). B: Compared to untreated hair strands, it has a penetration effect (penetrating 60% to 99% of the hair's cross-sectional area). C: Compared to untreated hair strands, there is a slight penetration effect (penetrating to 30% to 59% of the hair's cross-sectional area). D: Compared to untreated hair strands, there is no penetration effect at all (penetration occurs to less than 29% of the hair's cross-sectional area). The evaluation criteria for the inside of the skin were as follows, and a score of A to C was considered a passing grade. A: The penetration effect is significantly greater compared to an untreated 3D skin model (penetrating to 100% of the cross-sectional area of ​​the 3D skin model). B: Compared to an untreated 3D skin model, there is a penetration effect (penetration occurs to 60% to 99% of the cross-sectional area of ​​the 3D skin model). C: Compared to an untreated 3D skin model, there is a slight penetration effect (penetrating to 30% to 59% of the cross-sectional area of ​​the 3D skin model). D: Compared to an untreated 3D skin model, there is no penetration effect at all (penetration occurs in an area of ​​less than 29% of the cross-sectional area of ​​the 3D skin model).

[0063] (Effect of improving fracture strength) Hair strands damaged by bleaching (manufactured by Beaulux Co., Ltd.) were treated with 0.5g of each composition obtained above. After 60 minutes, the hair was rinsed with water, dried, and then measured using a tensile testing machine to evaluate the improvement in hair tensile strength. The evaluation criteria were as follows, and a grade of A to C was considered a passing grade. A: Compared to untreated hair bundles, the rate of increase in breaking strength is 15% or more. B: Compared to untreated hair bundles, the increase in breaking strength is 5% or more but less than 15%. C: Compared to untreated hair bundles, the increase in breaking strength is between 1% and 5%. D: The increase in breaking strength compared to untreated hair bundles is less than 1%.

[0064] (Enhances softness) Hair strands damaged by bleaching (manufactured by Beaulux Co., Ltd.) were coated with 0.5g of each composition obtained above. After 60 minutes, the hair was rinsed with water, dried, and then measured using a bending test machine to evaluate the rate of change in the hair's resistance to bending. The evaluation criteria were as follows, and a grade of A to C was considered a passing grade. A: The rate of change in bending resistance decreased by more than 10% compared to the control (hair strands that had been bleached and then coated with only dipropylene glycol). B: The rate of change in bending stiffness decreased by 5% to less than 10% compared to the control (hair strands bleached and coated only with dipropylene glycol). C: The rate of change in bending stiffness decreased by 1% to less than 5% compared to the control (hair strands bleached and coated only with dipropylene glycol). D: The rate of change in bending stiffness decreased by less than 1% compared to the control (hair strands treated with bleach and coated only with dipropylene glycol).

[0065] (Effect of improving hair and skin moisture content) Hair strands damaged by bleaching (manufactured by Beaulux Co., Ltd.) were treated with 0.5g of each composition obtained above. After 60 minutes, the hair was rinsed with water, dried, and then measured using an ultra-insulation meter to evaluate the improvement in hair moisture content. A one-month continuous application test was conducted on the scalp, cheeks, and arms of 20 panelists. Before application and after applying 0.5g of each composition obtained above, the improvement in skin moisture content was evaluated by washing the face, drying it, and then measuring it using a moisture content measuring device and a moisture evaporation measuring device. The evaluation criteria for hair moisture content were as follows, with A to C being considered a passing grade. A: The moisture content of the hair is 15% or more of the control (hair strands that have been bleached and then coated with only dipropylene glycol). B: The moisture content of the hair is between 10% and 15% of the control (hair strands that have been bleached and then coated with only dipropylene glycol). C: The moisture content of the hair is between 5% and less than 10% of the control (hair strands that have been bleached and then coated with dipropylene glycol only). D: Hair moisture content is less than 5% of the control (hair strands bleached and coated with dipropylene glycol only). The evaluation criteria for skin moisture content were as follows, with a score of A to C being considered a passing grade. A: Moisture content of the scalp, cheeks, and arms is 10% or more of the amount before application. B: Moisture content of scalp, cheeks, and arms is between 5% and 10% before application. C: Moisture content of scalp, cheeks, and arms is between 1% and 5% prior to application. D: Moisture content of scalp, cheeks, and arms is less than 1% of the pre-application level.

[0066] (Effect of suppressing cuticle peeling) Hair strands damaged by bleaching (manufactured by Beaulux Co., Ltd.) were coated with 0.5g of each composition obtained above. After 60 minutes, the hair was rinsed with water, dried, and then observed with an electron microscope (SEM) to visually evaluate the ability to suppress cuticle peeling. The evaluation criteria were as follows, and a grade of A to C was considered a passing grade. A: A significantly greater effect of cuticle adhesion is observed compared to untreated hair strands. B: Compared to untreated hair strands, the cuticle adhesion effect is more noticeable. C: A slight effect of cuticle adhesion is observed compared to untreated hair strands. D: The adhesion effect on the cuticle is the same as (or completely absent) that of an untreated hair strand.

[0067] (Improved combing effect) Hair strands damaged by bleaching (manufactured by Beaulux Co., Ltd.) were treated with 0.5g of each composition obtained above. After 60 minutes, the hair was rinsed with water, dried, and then the combability was evaluated by measuring with a combing tester. The evaluation criteria were as follows, and a grade of A to C was considered a passing grade. A: The load applied to combing is less than 50% compared to untreated hair strands. B: The load applied to combing is 50% to less than 60% compared to untreated hair strands. C: The load applied to combing is 60% to less than 70% compared to untreated hair strands. D: The load applied to combing is 70% or more compared to untreated hair strands.

[0068] The evaluation results are shown in Table 1.

[0069] [Table 1]

[0070] Based on the results above, the ceramide complex-containing compositions of Examples 1-9 showed improved performance in all evaluations compared to the compositions of Comparative Examples 1 and 2, which lacked either ceramide or betaine, and the composition of Comparative Example 3, which lacked both. From the results of Examples 5-6, in particular, the effects were further improved when the molar ratio of ceramide to betaine (amphoteric surfactant) was 1:3 to 3:1.

[0071] (Examples 10-13) A ceramide complex-containing composition was obtained in the same manner as in Example 5, except that a dihydric alcohol shown in Table 2 was used instead of dipropylene glycol.

[0072] (Comparative Examples 4-6) A composition was obtained in the same manner as in Example 5, except that a polyhydric alcohol shown in Table 2 was used instead of dipropylene glycol.

[0073] The evaluation results are shown in Table 2.

[0074] [Table 2]

[0075] The results above show that good effects similar to those in Example 5 were obtained with other dihydric alcohols. On the other hand, the compositions of Comparative Examples 4 to 6, which used trihydric or polyhydric alcohols, did not yield good results.

[0076] (Examples 14-17) A ceramide complex-containing composition was obtained in the same manner as in Example 5, except that each of the ceramides shown in Table 3 was used instead of ceramide 2.

[0077] The evaluation results are shown in Table 3.

[0078] [Table 3]

[0079] From the results above, it can be seen that good effects similar to those in Example 5 were obtained even with other ceramides.

[0080] (Examples 18-21) A ceramide complex-containing composition was obtained in the same manner as in Example 5, except that the amphoteric surfactants shown in Table 4 were used instead of cocamidopropyl betaine.

[0081] The evaluation results are shown in Table 4.

[0082] [Table 4]

[0083] From the results above, it can be seen that good effects similar to those in Example 5 were obtained with other amphoteric surfactants as well.

[0084] <Prescription Example 1> Examples of facial cleanser formulations containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0085] [Table 5]

[0086] <Prescription Example 2> The following table shows examples of body soap formulations containing the ceramide complex-containing composition according to the present invention. The units in the table are in mass percent.

[0087] [Table 6]

[0088] <Prescription Example 3> Examples of shampoo formulations containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0089] [Table 7]

[0090] <Prescription Example 4> Examples of hand soap formulations containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0091] [Table 8]

[0092] <Prescription Example 5> Examples of shampoo formulations containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0093] [Table 9]

[0094] <Prescription Example 6> Examples of conditioner formulations containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0095] [Table 10]

[0096] <Prescription Example 7> Examples of treatment formulations containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0097] [Table 11]

[0098] <Prescription Example 8> Examples of hair oil formulations containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0099] [Table 12]

[0100] <Prescription Example 9> Examples of hair milk formulations containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0101] [Table 13]

[0102] <Prescription Example 10> Examples of formulations for a hair styling mist containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0103] [Table 14]

[0104] <Prescription Example 11> Examples of formulations for lotions, serums, and scalp serums containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0105] [Table 15]

[0106] <Prescription Example 12> Examples of makeup remover formulations containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0107] [Table 16]

[0108] <Prescription Example 13> Examples of solid shampoo formulations containing the ceramide complex-containing composition according to the present invention are shown in the table below. The units in the table are in mass percent.

[0109] [Table 17]

Claims

1. A ceramide complex-containing composition comprising a ceramide complex comprising a ceramide, a dihydric alcohol, and an amphoteric surfactant.

2. The ceramide complex-containing composition according to claim 1, wherein the molar ratio of the ceramide to the amphoteric surfactant is 5:1 to 1:

5.

3. The ceramide complex-containing composition according to claim 1, wherein the ceramide is a ceramide with a naturally derived structure.

4. The ceramide complex-containing composition according to claim 1, wherein the ceramide comprises one or more selected from ceramide 1, ceramide 2, ceramide 3, ceramide 5, and ceramide 6B.

5. The ceramide complex-containing composition according to claim 1, wherein the dihydric alcohol comprises one or more selected from isoprene glycol, propylene glycol, 2,3-butylene glycol, 1,3-butylene glycol, and dipropylene glycol.

6. The ceramide complex-containing composition according to claim 1, wherein the amphoteric surfactant is a betaine-type surfactant.

7. The ceramide complex-containing composition according to claim 1, wherein the amphoteric surfactant comprises at least one of an aminoacetic acid betaine type surfactant and a sulfobetaine type surfactant.

8. A cosmetic comprising a ceramide complex-containing composition according to any one of claims 1 to 7.

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