Circulation system and method

Abstract

To provide a system for delivering fluids to animals. [Solution] The system includes a reservoir 12 for holding a certain amount of fluid 14, a delivery outlet, a recirculation loop, and a valve 40 for fluid communication between the reservoir and the delivery outlet, the valve having an inlet for receiving fluid from the reservoir, a first outlet for fluid communication with the delivery outlet, and a second outlet for fluid communication with a return conduit to the reservoir. The system further includes control means for opening and closing the first and second valve outlets, and a pump 32 for injecting fluid from the reservoir to the valve and into the reservoir through the reservoir return conduit. When the control means opens the first outlet, fluid flows from the reservoir 12 to the delivery outlet. When the control means opens the second valve outlet, fluid flows into the reservoir through the return conduit.

Description

Technical Field

[0001] Priority This application claims priority from U.S. Provisional Patent Application Serial No. 62 / 703247, filed on July 25, 2018. The content thereof is incorporated herein in its entirety. This application was filed on July 10, 2019, and refers to PCT International Application No. PCT / US19 / 41178, entitled SYSTEMS AND METHODS OF PREPARING AND DEIVERING OOCYST SOLUTIONS.

Background Art

[0002] Infections by bacteria, viruses and fungi and other diseases are often prevented or treated by vaccination or delivery of drugs to a subject. In all animals, particularly vertebrates such as mammals or fish, and invertebrates such as crustaceans, the delivery of vaccines, biologics, and other pharmaceuticals is often utilized to prevent disease, death, or to maintain overall good health. In many livestock and fish operations, it is a challenge to ensure that all animals are effectively treated. Some vaccines, biologics and other pharmaceuticals have microparticles in solution. In particular, some vaccines have live cultures in solution. Changes in the size of the particles in the solution can affect delivery due to sedimentation or clogging of the particles leading to a lack of uniformity during delivery. If the particles are not uniformly suspended in the solution, some subjects may receive more or

[0003] fewer amounts of the pharmaceutical than others. ​​​​​​​​​​​It may receive fewer particles.

[0004] Turning to the poultry industry, there are several current practices that involve treating fertilized eggs or chickens with pharmaceuticals. There are laws. These include the following: 1) Automated incubator vaccination performed in ovo (in the egg) on ​​day 18 or 19 at the hatchery. inoculation; 2) Manual vaccination at the hatchery after hatching; 3) Vaccinations / medicines added to the feed or water of the breeding facility; and 4) Vaccines / medicines sprayed onto chicks by either manual or mass sprayers.

[0005] Furthermore, new systems and methods for delivering vaccines and other substances to animals have been developed. The system and method are designed to automatically deliver substances to animals. It is disclosed in PCT / US2016 / 061548, and its contents are as follows: The whole is incorporated herein. The system separates each animal, especially chicks that are one day old. This includes a series of conveyor belts and other moving platforms for the chicks to be placed in a row. When separated into states (single file formations), the system, One or more doses of vaccines, pharmaceuticals, biological products, supplements, or other substances administered to individual animals It can be delivered to the eyes, nasal cavity, or mouth (if the chick's beak is open). Includes a nozzle for delivering a substance to the mucous membrane area of ​​the face of a chick, such as a baby bird. The nozzle is for air spraying or It may be a hydraulic type.

[0006] Vaccines, pharmaceuticals, biologics, or supplements are often delivered in solution. The active ingredients of vaccines, pharmaceuticals, biological products, or supplements are usually easier to obtain. For effective delivery, it is diluted in a solution such as water or saline. In the case of vaccines, Live cultures containing oocysts are suspended in solution for effective delivery. One type of oocyst vaccine is a "system for preparing and delivering oocyst solutions." Systems and Methods of Preparing an PCT / U This is described in detail in S19 / 41178, which is incorporated herein by reference in its entirety. It can be done.

[0007] In some situations, to effectively and uniformly deliver the active ingredient, the active ingredient is placed in the solution. Because the solution needs to be kept suspended, it becomes difficult to use a nozzle to deliver the solution. It is possible. Live cultures may lead to uneven delivery, so the reservoir (rese (rvoirs), tanks, vaccine bags, vaccine lines, nozzles or the bottom of other containers It cannot be allowed to settle. Uneven vaccination may result in some animals being unable to respond to higher doses. This occurs when one animal ingests the substance while other animals do not.

[0008] In the past, nozzles or spray heads were used for uneven delivery. It has been primed to prevent this. However, this method is Wasting material or having the system operator prime the spray head If this is forgotten, it is often ineffective. When this happens, many animals will not receive effective vaccine granules. They do not accept offspring. This is because when these birds are exposed to pathogens while growing, the risk of infection is low. This causes performance issues and outbreaks. Furthermore, nozzle priming The hatchery requires a significant amount of money every year for the amount of vaccine that is wasted like this.

[0009] The embodiments described herein provide a system and method for delivering a substance to an animal that does not require priming of the spray head every time the process is interrupted. This system can keep the substance suspended in solution while the system is operating or at rest. SUMMARY OF THE INVENTION

[0010] Summary The embodiments described herein relate to a system and method for delivering a fluid to an animal. The system has a reservoir for holding an amount of fluid, a delivery outlet, and a recirculating loop. The system also includes a valve that provides fluid communication between the reservoir and the delivery outlet. The valve has an inlet for receiving fluid from the reservoir, a first outlet in fluid communication with the delivery outlet, and a second outlet in fluid communication within the recirculating loop. The system further includes control means for controlling the position of the valve outlet, a reservoir pump for injecting fluid from the reservoir into the valve, and a recirculation pump for injecting fluid into the recirculating loop. When the control means opens the valve outlet toward the first outlet, fluid flows from the reservoir to the delivery outlet. When the control means closes the first outlet and opens the valve outlet toward the second outlet, the fluid flows within the recirculating loop.

[0011] BRIEF DESCRIPTION OF THE DRAWINGS Having thus described various embodiments of the present disclosure in general terms, reference will now be made to the accompanying drawings. The drawings are not drawn to scale and do not include all components of the system. ​​​​​​​​​ Not just that. [Brief explanation of the drawing]

[0012] [Figure 1] Figure 1 is a schematic diagram of the system according to the first embodiment. [Figure 2A] Figure 2A is a cross-sectional view of a portion of the nozzle and valve in the first embodiment in delivery mode. [Figure 2B] Figure 2B is a cross-sectional view of the nozzle and valve of the first embodiment in recirculation mode. [Figure 3] Figure 3 is a schematic diagram of the system according to the second embodiment. [Modes for carrying out the invention]

[0013] Detailed explanation This disclosure relates to systems and methods for delivering fluids to animals. Various aspects of this disclosure The views are shown below, with reference to the attached drawings, which show some, though not all, aspects. It is explained more thoroughly. In fact, this disclosure can be embodied in many different forms. This specification should not be construed as being limited to the aspects described herein.

[0014] One embodiment describes the incubation of chickens after they have been separated from their shells and before they leave the hatchery. This relates to the delivery of substances to newly hatched chicks. Furthermore, it relates to the methods and aspects of this disclosure relating to chicks. The system includes chickens, turkeys, ducks, geese, quail, pheasants, and ostriches. It can be used for any type of poultry, including but not limited to introduced birds. ru.

[0015] The system and method of this embodiment are used in connection with the delivery of fluids to animals. Morphologically, the system sprays fluid onto the mucous membranes (eyes, nasal cavity, or mouth) of one-day-old chicks. This is achieved by separating the chicks individually and placing them in front of the spray head. This is part of the first embodiment described below. The fluid is sprayed through the spray head, and the 1-day-old It is delivered to the mucous membrane of the chick's face.

[0016] Figure 1 shows a simplified schematic diagram of the entire system of the first embodiment 10. The system includes a reservoir 12 filled with fluid 14. Fluid 14 contains a vaccine diluted in solution. It may be a pharmaceutical, biological product, or supplement. The diluent may be water, saline solution, etc. It's okay to have it.

[0017] The reservoir 12 includes a fluid inlet or opening 16 into which the fluid 14 is poured before use. The inlet has a cap or cover 18 that is securely fixed to the reservoir 12 during use. The reservoir 12 also has a pressurized air inlet 60. The pressurized air inlet 60 is a first pressurized air The first pressure regulator 2 is connected to the pressurized air supply unit 20 by an air conduit 22. 4 is positioned along the first pressurized air conduit 22 and controls the pressure along the first pressurized conduit. .

[0018] The reservoir 12 further includes a fluid outlet 26. The fluid outlet 26 is connected to the first fluid conduit 28 The first fluid conduit 28 is connected to the recirculation pump inlet 30 on the recirculation pump 32. It is connected to the recirculation pump 32, which has a pump fluid outlet 34. 4 is connected to the second fluid conduit 36. The second fluid conduit 36 ​​is connected to the valve fluid inlet 3 It is connected to 8. The valve fluid inlet 38 is attached to the three-way valve 40. Bu 40 has a fluid inlet 56 and two outlets, as shown in Figures 2A and 2B, i.e. It has a bypass port 46 and an exit port 44. The bypass port 46 is as follows: When the bypass function, which is described in detail, is activated, the bypass receives fluid from valve 40. It is in fluid communication with outlet 42. The outlet position of valve 40 is not shown in the diagram. Programmable logic controller It is electronically controlled by the controller.

[0019] The bypass outlet 42 is in fluid communication with the bypass conduit 45, as shown in Figure 1. The bypass conduit 45 is in fluid communication with the bypass inlet 47. The bypass inlet 47 is a bypass conduit. A fluid opening for the conduit 45 is provided in the reservoir 12.

[0020] Valve 40 is in one of two positions, namely the spray position shown in Figure 2A. Alternatively, it should be noted that it could be in one of the recirculation positions as shown in Figure 2B. The spray position is when the outlet port 44 is open and the bypass port 46 is closed. The recirculation position is when the bypass port 46 is open and the outlet port 44 is closed.

[0021] The valve outlet port 44 has a delivery nozzle spray head 54, as shown in Figure 1. The nozzle outlet conduit 48 is connected to the delivery nozzle 50. In this configuration, the nozzle spray head 54 is also connected to the pressurized air source 52. The pressurized air mixes with the fluid coming out of the spray head 54 and is delivered as a mist spray to the animal. Create a file. This will be explained in more detail below.

[0022] During use, the pressurized air supply unit 20 supplies pressurized air to the reservoir 12 via the pressurized air inlet 60. It is introduced. A solution of vaccine, pharmaceutical, biological product, or supplement suspended in a diluent. The fluid 14 is held in the reservoir 12. When the pressurized air supply unit 20 is activated, the fluid Body 14 recirculates fluid from the reservoir along the first fluid conduit 28 via the fluid outlet 26. The fluid exits into the pump inlet 30. The recirculation pump 32 takes the fluid 14 from the pump to the pump fluid outlet 3. The fluid is then moved through 4 and the second fluid conduit 36 ​​into the valve fluid inlet 38.

[0023] During use for delivering fluid to animals, the animals are positioned in close proximity to the nozzle spray head 50. At that time, the valve controller 46 opens the outlet port 44, and this action simultaneously Close the passport 42. This allows the fluid 14 to exit the outlet as shown in Figure 2A. The fluid flows through tube 44, through nozzle outlet conduit 48, and into nozzle spray head 50. In the nozzle spray head 50, the fluid 14 is mixed with pressurized air from the pressurized air source 52. This causes the fluid 14 to be atomized, and the atomized fluid 14 is then atomized and the mucus of nearby 1-day-old chicks. It is sprayed onto the membrane.

[0024] If the first embodiment 10 is not used to deliver fluid to an animal, the valve The controller 46 closes the exit port 44, which at the same time causes the bypass port 42 to open. This includes the exit port 56, bypass port 42, bypass conduit 45, and bypass inlet. This provides a flow of fluid 14 from valve 40 back to reservoir 12 via 47. Therefore, recirculation maintains the fluid 14 as a uniform suspension and prevents the vaccine components from settling. The fluid 14 continues to recirculate in this manner until it needs to be delivered to the animal. Lube 40 is directed as described above, and the fluid 14 is directed through the nozzle spray head 54. It is then delivered to the animals.

[0025] The types of vaccines or other substances administered to chicks by spray application to mucous membranes include these. While not limited to these, viruses such as Newcastle disease and infectious bronchitis virus, and Escherichia coli. , against bacteria such as Salmonella and Campylobacter, and parasites such as Coccidia It is expected to include a vaccine.

[0026] Figure 3 shows the second embodiment 60. The second embodiment 60 is, in some respects, a reservoir Similar to the first embodiment 10, which has a fluid 14 containing -12 and particles suspended therein The reservoir 12 supplies fluid to the pump 32 via the fluid outlet 26 and the first conduit 28. They are in communication. The pump fluid outlet 34 is connected to the bypass conduit 45 and the bypass inlet 47. Furthermore, the pump outlet 34 has a delivery nozzle 50 having a delivery nozzle spray head 54. It is connected to a valve 62 that is in fluid communication with it. The delivery nozzle relates to the first embodiment 10. It operates and is controlled as described above.

[0027] During use, the fluid 14 in the reservoir 12 is supplied to the pump outlet 34 via the pump 32. It is transported through the bypass conduit 45 and then through the bypass inlet 47 to the reservoir. It is returned. When valve 62 is activated, the fluid 14 is simultaneously released through the valve into nozzle 50. and is moved outside the nozzle spray head 54. The fluid 14 mixes with the pressurized air source 52. This creates a mist-like spray profile that is directed towards the mucous membrane area of ​​the animal's face.

[0028] To see if the recirculation pump can maintain particles in the vaccine solution suspension, try The experiment was conducted. The vaccine in the solution contained Eimeria, which has at least three types of oocysts. These were vaccines. These included E. maxima, E. tenella, and E. acer The solution contained vulina. After keeping the nozzle still for 10 minutes, the solution was sprayed onto the designated surface. The change in vaccine count is due to the delivery of oocysts from three different species via the nozzle over time. It was detected by counting. B1 represents nozzle 1, and B2 represents nozzle 2. Each spray was counted, and the number of each species was calculated for each sample. A 10-minute break was then observed. The deviation of the counts before and after the measurement was less than 15%. The results are shown in Table 1 below. The standard error of counting with a small sample size is close, and the recirculation loop to the nozzle solves the sedimentation problem. It was shown that it was determined. Previously, in a study of delivery without a recirculation function, after a 10-minute interruption, A significant decrease in the number of cysts was detected.

[0029] [Table 1]

[0030] The embodiments described herein describe the automatic application of a substance to the mucous membranes of other animals and mammals, including humans. It is also anticipated that this may be applicable to delivery. In particular, to the facial mucosa of infants or children, or persons with disabilities. There may be certain applications suitable for the automated delivery of substances to [location]. Furthermore, as described herein The automated delivery system is for livestock, companion animals, rodents, and commercially raised animals. This can be applied to other animals, such as other animals that are present.

[0031] Many modifications and other aspects of this disclosure described herein are as described above and related to the figures. It is expected that this disclosure will be recalled by those skilled in the art who have an interest in the teachings presented herein. Therefore, this disclosure is not intended to be limited to any particular aspect disclosed. It is understood that any modifications and other aspects are intended to be included in the attached claims. It should be done. While specific terms are used in this specification, they are general and descriptive. It is used only in a specific sense and not for restrictive purposes.

Claims

1. A reservoir containing a certain amount of fluid; delivery outlet; A valve that provides fluid communication between the reservoir and the delivery outlet, wherein the reservoir An inlet for receiving fluid from, a first outlet communicating with the delivery outlet, and a reservoir - A valve having a second outlet that is in fluid communication with the reservoir via a return conduit; Control means for opening and closing the first and second valve outlets; and The fluid is supplied from the reservoir to the valve, and from the valve back to the reservoir. A pump for continuously injecting into the reservoir through a pipe. Includes, As a result, the control means opens the first valve outlet and closes the second valve outlet. Then, the fluid flows from the reservoir to the delivery outlet, and the control means controls the first valve When the valve outlet is closed and the second valve outlet is opened, the fluid flows through the reservoir return conduit. The following flows into the reservoir: A system for delivering fluids to animals.

2. The system according to claim 1, wherein the delivery outlet is a nozzle.

3. Claim 2, wherein the nozzle is either an air mist spray nozzle or a hydraulic spray nozzle. The system described.

4. The system according to claim 1, wherein the delivery outlet is an injector.

5. The system according to claim 4, wherein the injector is needle-free.

6. Claim 1, wherein the control means includes a computer control system that communicates with the valve. The system described.

7. The flow velocity in the reservoir return conduit is approximately 60 milliliters per minute, as described in claim 1. The system.

8. The claim 1 further includes a pressure source communicating with the fluid reservoir and the pump. system.

9. The system according to claim 8, wherein the pressure source is approximately 15 psi.

10. The fluid is a vaccine, a biological product, a pharmaceutical product, or a supplement, as described in claim 1. The system.

11. The system according to claim 1, wherein the animal is a chicken.

12. A reservoir containing a certain amount of fluid; delivery outlet; The reservoir has an inlet that communicates with the fluid, and the first outlet and the delivery outlet have fluid communication. A three-way valve having two outlets, a second outlet that communicates with the reservoir return conduit. There is, The first outlet is opened and the second outlet is closed, and the discharge outlet is opened from the reservoir. A first position is provided that allows fluid to flow into the opening, and the second outlet is opened, and the first outlet A second position where the opening is closed, allowing fluid flow through the reservoir return conduit, A valve having a third position in which the first outlet and the second outlet are closed; Control means for controlling the position of the valve; and The fluid is supplied from the reservoir through the reservoir return conduit to the valve, and to the front Return the fluid to the reservoir and use a pump to continuously inject it. A system for delivering substances to animals, including [specific components / methods].

13. The system according to claim 12, wherein the delivery outlet is a nozzle.

14. Claim 13, wherein the nozzle is either a spray nozzle or a hydraulic nozzle. The system described above.

15. The system according to claim 12, wherein the delivery outlet is an injector.

16. The system according to claim 15, wherein the injector is needle-free.

17. Claim 12 further includes a pressure source communicating with the fluid reservoir and the recirculation pump. The system described above.

18. The system according to claim 17, wherein the pressure source is approximately 15 psi.

19. Claim 12 states that the fluid is a vaccine, a biological product, a pharmaceutical, or a supplement. The system.

20. To provide a reservoir having a certain amount of fluid; To provide a delivery exit; A valve that provides fluid communication between the reservoir and the delivery outlet, wherein the reservoir An inlet for receiving fluid from, a first outlet communicating with the delivery outlet, and a reservoir - It has a second outlet that is in fluid communication with the return conduit, and the reservoir return conduit is the reservoir To provide a valve that communicates with fluids; and Continuously injecting fluid from the reservoir into the valve. Includes, As a result, when the first valve outlet opens, the second valve outlet closes, and the fluid moves forward. Flow from the reservoir through the first valve outlet to the delivery outlet, and the first When the valve outlet closes, the second valve outlet opens, and the fluid flows from the reservoir to the reservoir. The water flows back to the reservoir through the reservoir return conduit. A method for delivering fluids to animals.

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