Method for preparing a composition containing unfolding protein

A simplified method using a dry composition of polypeptides and specific salts forms biologically active complexes, addressing inefficiencies in existing methods by maintaining activity and reducing complexity and cost.

JP2026113563APending Publication Date: 2026-07-07

Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Filing Date
2026-04-01
Publication Date
2026-07-07

AI Technical Summary

Technical Problem

Existing methods for preparing biologically active complexes, such as HAMLET, are cumbersome and require freeze-drying, making them inefficient for storage and transportation, and there is a need for a simpler and more economical method that maintains biological activity.

Method used

A method involving a dry composition of polypeptides, fatty acids or their salts, and a buffering component of specific salts like sodium chloride and disodium phosphate, which is combined without water, allowing for easy reconstitution to form biologically active complexes.

Benefits of technology

The method enables the production of biologically active complexes that maintain activity levels comparable to freeze-dried counterparts, is simpler and more economical, and can be prepared without specialized equipment, suitable for various environments.

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Patent Text Reader

Abstract

This invention provides a method for preparing a composition containing unfolding proteins. [Solution] A method for preparing a composition comprising the steps of combining a) a dry polypeptide, b) a fatty acid or lipid, or a pharmaceutically acceptable salt thereof, and c) a buffering component comprising at least two salts, preferably the first salt being sodium chloride or potassium and the second salt being disodium phosphate or monopotassium phosphate, wherein the composition is substantially water-free.
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