Arthropod control composition

Abstract

The present invention provides an arthropod control composition that possesses both good olfactory properties, i.e., good comforting effects, and good arthropod control properties, particularly arthropod repellent properties. [Solution] An arthropod control composition containing (3Z)-3-butylidene-2-benzofuran-1-one, 4-ethenyl-2-methoxyphenol, grape leaf oil, labdanum extract, 5-pentyloxolan-2-one, chromen-2-one, (2E)-3,7-dimethylocta-2,6-dienal, 4-hydroxy-3-methoxybenzaldehyde, (5R)-2-methyl-5-propane-1-en-2-ylcyclohexa-2-en-1-one, spearmint oil, 6-hexyloxan-2-one, 5-methyl-2-propane-2-ylcyclohexyl acetate, kuranthes oil, 2-phenylethanol, 6-pentyloxan-2-one, etc.

Description

Technical Field

[0001] The present invention relates to an arthropod control composition, a method and use for controlling arthropods, and an arthropod control article containing the arthropod control composition.

[0002] Background Art Many mammals, including humans, are damaged by the activities of arthropods. For example, some arthropods such as mosquitoes and ticks bite, and as a result, cause itching, diseases and / or transmission of pathogens, or may cause other diseases and / or abnormalities, so they are not preferable for mammals, especially vertebrates such as human subjects.

[0003] The arthropod control composition contains an active substance and can prevent arthropods from stopping or crawling on the surface when applied to the skin, clothing or other surfaces. The arthropod control agent helps to suppress and control the occurrence of arthropod-borne diseases such as malaria.

[0004] However, some known arthropod control agents and arthropod control compositions have certain disadvantages because they may have negative effects, that is, negative olfactory characteristics such as odorless or malodorous, or only have weak arthropod control characteristics, especially arthropod repellent characteristics.

[0005] There is a need to provide an arthropod control composition having both good olfactory characteristics, that is, good comfort effects, and good arthropod control characteristics, especially arthropod repellent characteristics.

[0006] The prior art does not disclose or suggest the arthropod control composition according to the present invention.

Brief Description of the Drawings

[0007] [Figure 1-1]This figure shows the number of mosquitoes that landed on a heating element within 2 minutes after being treated with various substances at various concentrations. The test using ethanol alone (control) is shown as 0 mg / mL. [Figure 1-2] This figure shows the number of mosquitoes that landed on a heating element within 2 minutes after being treated with various substances at various concentrations. The test using ethanol alone (control) is shown as 0 mg / mL. [Figure 1-3] This figure shows the number of mosquitoes that landed on a heating element within 2 minutes after being treated with various substances at various concentrations. The test using ethanol alone (control) is shown as 0 mg / mL. [Figure 2-1] This figure shows the number of mosquitoes that landed on a heating element within 2 minutes while the cage air was treated with various substances at varying concentrations. The test using only the solvent (control) is shown as 0 μg / L of air, and nd indicates no data. [Figure 2-2] This figure shows the number of mosquitoes that landed on a heating element within 2 minutes while the cage air was treated with various substances at varying concentrations. The test using only the solvent (control) is shown as 0 μg / L of air, and nd indicates no data. [Figure 2-3] This figure shows the number of mosquitoes that landed on a heating element within 2 minutes while the cage air was treated with various substances at varying concentrations. The test using only the solvent (control) is shown as 0 μg / L of air, and nd indicates no data. [Figure 3] This figure shows the percentage of avoidance in the arm incage test. Each bar graph represents the mean avoidance ± SD for three volunteers, and nd indicates no data.

[0008] Detailed description The present invention relates to an arthropod control composition, preferably an insect control composition, comprising one or more substances, wherein the substances are (E)-1-(2,6,6-trimethylcyclohexa-2-en-1-yl)buta-2-en-1-one, (3Z)-3-butylidene-2-benzofuran-1-one, 4-ethenyl-2-methoxyphenol, grape leaf oil (cognac oil green), labdanum extract (Cistus spp.), 5-pentyloxolan-2-one, chromen-2-one, (2E)-3,7-dimethylocta-2,6-dienal, 4-hydroxy-3-methoxybenzaldehyde, (5R)-2-methyl-5-propa-1-en-2-ylcyclohexa-2-en-1-one, spearmint oil (Mentha spicata) [oil], 6-hexyloxan-2-one, 5-methyl-2-propane-2-ylcyclohexyl acetate, Nigella damascena oil, 2-phenylethanol, 6-pentyloxan-2-one, (4-methoxyphenyl)methyl acetate, Syzygium aromaticum oil, 3,4,4a,5,6,7,8,8a-octahydrochromen-2-one, (1S,6R)-3,7,7-trimethylbicyclo[4.1.0]hepta-3-ene, 2-phenylethyl 2-methylpropanoate, methyl 2-(3-oxo-2-penta-2-enylcyclopentyl) acetate, (4R)-4-(2-methoxypropane-2-yl)-1-methylcyclohexene, Mentha piperita oil Selected from the group consisting of oil, 2-methoxy-4-[(E)-propa-1-enyl]phenol, 2-methyl-3-(4-propan-2-ylphenyl)propanal, and (4-methoxyphenyl)methanol.

[0009] These substances in the compositions of the present invention are known in the art and can be readily synthesized or obtained. The following enumeration shows the CAS number for each of the substances: 5-pentyloxolan-2-one (CAS number 104-61-0), chromen-2-one (CAS number 91-64-5), 2-methyl-3-(4-propan-2-ylphenyl)propanal (CAS number 103-95-7), (4-methoxyphenyl)methanol (CAS number 105-13-5), (2E)-3,7-dimethylo Kuta-2,6-dienal (CAS No. 5392-40-5), 4-hydroxy-3-methoxybenzaldehyde (CAS No. 121-33-5), (5R)-2-methyl-5-propa-1-en-2-ylcyclohexa-2-en-1-one (CAS No. 6485-40-1), 4-ethenyl-2-methoxyphenol (CAS No. 7786-61-0), Labdanum extract Extract (Cistus spp.) (CAS No. 84775-64-4 / 8016-26-0), Grape Leaf Oil (Cognac oil green) (CAS No. 8016-21-5), (3Z)-3-Butylidene-2-benzofuran-1-one (CAS No. 551-08-6), (E)-1-(2,6,6-trimethylcyclohexa-2-en-1-yl)buta-2-en-1-one (CAS No. 24720-09-0), 6-hexyloxan-2-one (CAS No. 710-04-3), 5-methyl-2-propane-2-ylcyclohexyl acetate (CAS No. 2623-23-6), Nigella damascena oil oil) (CAS No. 73507-35-4 / 90064-31-6), 2-phenylethanol (CAS No. 60-12-8), 6-pentyloxan-2-one (CAS No. 705-86-2), (4-methoxyphenyl)methyl acetate (CAS No. 104-21-2), 3,4,4a,5,6,7,8,8a-octahydrochromen-2-one (CAS No. 4430-31-3), (1S,6R)-3,7,7-trimethylbicyclo[4.1.[0]hepta-3-ene (CAS No. 498-15-7), 2-phenylethyl 2-methylpropanoate (CAS No. 103-48-0), methyl 2-(3-oxo-2-penta-2-enylcyclopentyl) acetate (CAS No. 20073-13-6), (4R)-4-(2-methoxypropan-2-yl)-1-methylcyclohexene (CAS No. 30199-25-8), 2-methoxy-4-[(E)-propa-1-enyl]phenol (CAS No. 5932-68-3), spearmint oil (Mentha spicata oil) (CAS No. 8008-79-5 / 84696-51-5), clove oil (Syzygium aromaticum) Oil (CAS number 8000-34-8 / 68917-29-3) and peppermint oil (Mentha piperita oil) (CAS number 8006-90-4 / 84082-70-2).

[0010] In a particular embodiment, substances used for repellency, more preferably for mosquito repellency, include labdanum extract, cognac oil green, (3Z)-3-butylidene-2-benzofuran-1-one, 2-methyl-3-(4-propane-2-ylphenyl)propanal, methyl 2-(3-oxo-2-penta-2-enylcyclopentyl)acetate, Nigella damascena oil, (2E)-3,7-dimethylocta-2,6-dienal, 5-pentyloxollan-2-one, and clove oil (Syzygium aromaticum). Selected from oil, 4-ethenyl-2-methoxyphenol, 4-hydroxy-3-methoxybenzaldehyde, 6-pentyloxan-2-one, (1S,6R)-3,7,7-trimethylbicyclo[4.1.0]hepta-3-ene, chromen-2-one, 6-hexyloxan-2-one, 2-methoxy-4-[(E)-propa-1-enyl]phenol, 5-methyl-2-propane-2-ylcyclohexyl]acetate, and (4-methoxyphenyl)methanol.

[0011] In a particular embodiment, the substance used for repellency, more preferably for mosquito repellency, is selected from (3Z)-3-butylidene-2-benzofuran-1-one, methyl 2-(3-oxo-2-penta-2-enylcyclopentyl) acetate, Nigella damascena oil, (2E)-3,7-dimethylocta-2,6-dienal, Syzygium aromaticum oil, 6-pentyloxan-2-one, chromen-2-one, 2-phenylethyl 2-methylpropanoate, and 4-ethenyl-2-methoxyphenol.

[0012] In special embodiments, substances used for spatial repellent, more preferably for mosquito spatial repellent, include: Cognac oil green, (E)-1-(2,6,6-trimethylcyclohexa-2-en-1-yl)buta-2-en-1-one, 2-methyl-3-(4-propan-2-ylphenyl)propanal, 4-ethenyl-2-methoxyphenol, methyl 2-(3-oxo-2-penta-2-enylcyclopentyl)acetate, 6-hexyloxan-2-one, chromen-2-one, 6-pentyloxan-2-one, peppermint oil (Mentha piperita oil), 4-hydroxy-3-methoxybenzaldehyde, clove oil (Syzygium aromaticum oil), 5-pentyloxolan-2-one, 2-phenylethanol, kuranthes oil (Nigella damascena oil), spearmint oil (Mentha Selected from spicata oil, (5R)-2-methyl-5-propa-1-en-2-ylcyclohexa-2-en-1-one, 2-methoxy-4-[(E)-propa-1-enyl]phenol, (4-methoxyphenyl)methanol, (4R)-4-(2-methoxypropan-2-yl)-1-methylcyclohexene, 2-methoxy-4-[(E)-propa-1-enyl]phenol, and (4-methoxyphenyl)methyl acetate.

[0013] In a particular embodiment, the substance used for spatial repellent, more preferably for mosquito repellent, is selected from 4-ethenyl-2-methoxyphenol, methyl 2-(3-oxo-2-penta-2-enylcyclopentyl) acetate, chromen-2-one, 6-pentyloxan-2-one, peppermint oil (Mentha piperita oil), and 4-hydroxy-3-methoxybenzaldehyde.

[0014] In a particular embodiment, the substance used for restorative purposes, more preferably for tick restorative purposes, is selected from (E)-1-(2,6,6-trimethylcyclohexa-2-en-1-yl)buta-2-en-1-one, 4-ethenyl-2-methoxyphenol, (3Z)-3-butylidene-2-benzofuran-1-one, 5-pentyloxolan-2-one, chromen-2-one, 2-methoxy-4-[(E)-propa-1-enyl]phenol, and 2-methyl-3-(4-propan-2-ylphenyl)propanal.

[0015] In a particular embodiment, the substance used for inhibition, more preferably for tick inhibition, is selected from 4-ethenyl-2-methoxyphenol, (3Z)-3-butylidene-2-benzofuran-1-one, 5-pentyloxolan-2-one, and 2-methoxy-4-[(E)-propa-1-enyl]phenol.

[0016] In a special embodiment, the arthropod control composition contains a compound or composition in an amount of 0.01 to 90% by weight, more preferably 0.2 to 30% by weight, based on the total weight of the composition.

[0017] In a preferred embodiment of the present invention, the arthropod control composition has a good comfort profile.

[0018] The inventors are fully aware that for an arthropod control composition, it may sometimes be desirable to have an acceptable comfort profile. This is because the composition may be used in close proximity to consumers, and an unpleasant comfort profile may inhibit the use of the composition as it needs to be understandable.

[0019] The term "arthropod" has its ordinary meaning to those skilled in the art. Arthropods include invertebrates such as insects, arachnids, and crustaceans, and have a segmented body and jointed appendages. Arthropods typically have a chitinous exoskeleton that molts at intervals and a dorsal brain connected to a ventral chain of ganglia.

[0020] The arthropods in the context of the present invention relate to undesired arthropods, and this undesired arthropod means that it is not desirable to be present in the air, on the surface of articles, on the surface of plants, or on the surface of a vertebrate such as a human subject or other mammal, preferably a human subject. Preferably, the undesired arthropods are harmful arthropods that affect plants and animals, such as thrips, aphids, beetles, moths, flour beetles, click beetles, etc., more preferably harmful arthropods that affect animals, such as ants, termites, cockroaches, flies, etc., even more preferably blood-sucking arthropods that affect vertebrates, such as biting flies, bed bugs, ticks, fleas, lice, mosquitoes and mites, even more preferably mosquitoes and mites.

[0021] The reason why the presence of arthropods is not desirable is that the presence of arthropods in the air is unpleasant for the subject, the contact of arthropods on articles spreads diseases and / or pathogens, or arthropods bite organisms causing itching, may spread diseases and / or pathogens, or the ingestion of arthropods may cause other diseases and / or abnormalities.

[0022] In a particular embodiment, the arthropod is an insect or an arachnid, preferably an insect.

[0023] The term "insect" has the ordinary meaning to those skilled in the art. Insects are represented by a clearly defined head, thorax, and abdomen, only three pairs of legs, and typically one or two pairs of wings.

[0024] In a particular embodiment, the insect is a mosquito, biting fly, bedbug, tick, flea, lice, ant, termite, cockroach, fly, aphid, beetle, thrips, moth, weevil or flour beetle, more preferably a mosquito.

[0025] The term "arachnids" has the ordinary meaning to those skilled in the art. Arachnids have a segmented body divided into two regions, and the front region is represented as having four pairs of legs but no antennae.

[0026] In a particular embodiment, the arachnids are mites, ticks, chiggers, or spiders, more preferably mites.

[0027] Expressions such as "control", "arthropod control", "insect control" or "arachnid control" have the ordinary meaning to those skilled in the art.

[0028] In the context of the present invention, "control" defines the ability of an arthropod control composition according to the present invention to attract, deter, kill or repel arthropods, preferably the ability to deter or repel arthropods, and even more preferably the ability to repel arthropods.

[0029] "Attraction" according to the present invention defines the ability of an arthropod attraction composition according to the present invention to increase or facilitate the contact or presence of arthropods at an arthropod attraction source, such as in the air, on the surface of an article or on the surface of a vertebrate, for example a human subject or other mammal, to which an arthropod attraction compound or composition has been applied, preferably on an article such as a trapping device.

[0030] The term "repellent" in the present invention refers to the ability of the arthropod repellent composition according to the present invention to minimize, reduce, hinder or prevent the entry or presence of arthropods in the air, on the surface of an article, or in an arthropod repellent source such as a vertebrate, for example, a human subject or other mammal, preferably on the surface of a human subject, to which the arthropod repellent compound or composition is applied.

[0031] The term "inhibitory" in the present invention refers to the ability of the arthropod inhibitory composition according to the present invention to minimize, reduce, hinder or prevent arthropod contact or presence of arthropods in the air, on the surface of an article, or at an arthropod inhibitory source such as a vertebrate, for example, a human subject or other mammal, preferably on the surface of a human subject, to which the arthropod inhibitory compound or composition is applied. Typically, this inhibitory effect is demonstrated when used as a feeding inhibitor to prevent subsequent feeding, spawning, or physical contact of a pest after the arthropod inhibitory compound or composition has been initially ingested.

[0032] The “spatial repellent” aspect of the present invention defines the ability of the arthropod repellent composition according to the present invention to minimize, reduce, hinder, or prevent the entry or presence of arthropods in the air, on the surface of an article, or at an arthropod repellent source such as a vertebrate, for example, a human subject or other mammal, preferably on the surface of a human subject, to which the arthropod repellent compound or composition is applied. Typically, this spatial repellent effect is demonstrated when, when the spatial repellent compound or composition is released, sprayed, scattered, or emitted into the air or liquid, it prevents pests from entering the area where the spatial repellent compound or composition is present. Thus, the repellent occurs from a distance, and the pests do not necessarily need to come into direct contact with the article or organism treated for protection.

[0033] "Killing" in the present invention defines the ability of the arthropod-killing composition according to the present invention to kill arthropods in the air, on the surface of an article, or in an arthropod-killing source such as a vertebrate, for example, a human subject or other mammal, preferably the surface of a human subject, to which the arthropod-killing compound or composition is applied. When the arthropod-killing composition is applied to a plant, animal or human subject, the arthropod-killing composition is applied in an amount that kills arthropods but does not kill the subject.

[0034] In a special embodiment, the arthropod control composition is an arthropod repellent composition, preferably an insect repellent composition, and more preferably a mosquito repellent composition.

[0035] In a particular embodiment, the arthropod control source is an article, preferably a candle, coil, electric diffuser, wristband, patch, collar, ear tag, clothing, fabric, paper, biochar, cardboard, cellulose pad, mosquito net, screen, curtain, furniture, wall, ground or painted surface and / or the air near it, or a subject's surface, preferably a vertebrate, such as a human subject or other mammal, preferably a human subject's surface, i.e., the skin of a human subject treated with a product such as a spray, aerosol, cream, roll-on, wristband, lotion, soap, shampoo, sunscreen or patch, or a fabric treated with a product such as a laundry powder, liquid detergent, spray, lotion, or powder.

[0036] The arthropod control effect of the present invention is determined for mosquitoes using an in vitro assay for testing mosquito controlling compounds employing a warm body and carbon dioxide as a behavioral activator, as specified in J Am Mosq Control Assoc. 2010; 26:381-386, an adapted warm body assay. Further information is provided in the attached examples.

[0037] The control efficacy, repellency, and spatial repellency according to the present invention were determined by testing a warm body assay against the Rockefeller strain of Aedes aegypti, the yellow fever mosquito. Aedes aegypti is a model organism for control testing and is one of the model organisms recommended by the World Health Organization (WHO) because it is an extremely aggressive and anthropogenic mosquito species that generally shows low susceptibility to arthropod control compounds. Observations of control efficacy were made on host-seeking females of uniform age, 5–10 days post-emergence, selected as described in the above publication. The hungry females tested had access to a 10% sugar solution but were not given blood. Further information is provided in the attached examples.

[0038] The published protocol is adapted for automatic counting using automated counting software, rather than for manually counting stationary mosquitoes. The switch from Anopheles gambiae to Aedes aegypti resulted in a reduction in the number of mosquitoes placed in the tested cages due to the size difference (i.e., 30 mosquitoes instead of 50) and an increase in lighting (i.e., 150 lux instead of 4 lux) because Aedes aegypti are diurnal mosquitoes. Further information is provided in the attached examples.

[0039] The control, repellent, and spatial repellent effects of the present invention were also determined according to the arm-in-the-box method applied from the WHO guidelines for testing the efficacy of mosquito repellents on human skin (WHO / CDS / NTD / WHOPES / 2009.4). Preparation of 100 hungry female Aedes aegypti mosquitoes for the test substance was evaluated by comparing the results of an untreated arm (negative control) to a treated arm three times after insertion into a cage (40 × 40 × 40 cm) for 30 seconds. Further information is provided in the attached examples.

[0040] The activity of substances that repel ticks and other arachnids was evaluated using an in-vitro warm plate assay, as defined in Kroeber T, Bourquin M, Guerin PM, 2013, using the protocol of Pestic. Biochem. Phys. 107(2):160-168. Further information is provided in the attached examples.

[0041] In particular embodiments, the amount and selection of substances are determined to contribute to, enhance, or improve both the arthropod control activity and the comfort properties of the composition.

[0042] In one embodiment, the arthropod control composition may further contain arthropod control auxiliary components. "Arthropod control auxiliary components" are interpreted as components that can provide additional arthropod control benefits to the arthropod control effect of the compositions described herein.

[0043] In one embodiment, the substances described herein can be modified, enhanced, or improved in their arthropod control effect by, for example, reducing the amount of the arthropod control aid in the composition. This can be particularly beneficial when the arthropod control aid is harmful to human subjects at a particular dose or when the arthropod control aid has unfavorable olfactory properties at a particular dose.

[0044] According to a specific embodiment, the combination of the substance described herein with an arthropod control auxiliary component results in a synergistic arthropod control effect.

[0045] According to specific embodiments, combinations of the substances described herein with arthropod control aids result in modifications, enhancements, or improvements to the olfactory impression of the overall composition compared to the single components.

[0046] According to one embodiment, the arthropod control aid components are N,N-diethyl-3-methylbenzamide (DEET), ethylbutylacetylaminopropionate (IR3535); para-menthane-3,8-diol (PMD); 1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine (icaridin);Cedarwood oil (China), cedarwood oil (Texas), cedarwood oil (Virginia), cinnamon oil, citronella oil, corn mint oil, fractionated hydrated cyclized citronella oil (Cymbopogon winterianus oil fractionated hydrated cyclized), decanoic acid, eucalyptus citriodora oil, hydrated cyclized eucalyptus citriodora oil, eugenol, garlic oil, geraniol, geranium oil, lavender, Lavandula hybrida extract, lavandin oil, lemon oil, lemongrass oil, margosa extract, metofluthrin, mixture of cis- and trans-p-menthane-3,8-diol, N,N-diethyl-meth-toluamide, nonanoic acid, rosemary oil, thyme oil, wintergreen oil, 2,3,4,5-bis(butyl-2-ene)tetrahydrofurfural (MGK Repellent 11) Cineole, cinnamaldehyde, citronellal, citronellol, coumarin, dibutylphthalate, diethylphthalate, dimethylanthranillate, dimethylphthalate, ethyl vanillin, eucalyptus oil, delta-octaractone, delta-nonalactone, delta-decalactone, delta-undecalactone, delta-dodecalactone, gamma-octaractone, gamma-nonalactone, gamma-decalactone, gamma-undecalactone, gamma-dodecalactone, hydroxycitronellal, lime oil, limonene, linalool, methylanthranillol Spicy cocoate, peppermint oil, myrcene, neem oil, sabinene, β-caryophyllene, (1H-indole-2-yl)acetic acid, anethole, anise oil, basil oil, bay oil, camphor, ethyl salicylate, evergreen oil (pine oil), (1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindole-2-yl)methyl(1R-trans)-2,2-dimethyl-3-(2-methylpropane-1-enyl)cyclopropanecarboxylate (d-tetramethrin), (RS)-3-allyl-2-methyl-4-oxocyclopenta-2-enyl-(1R,3R;1R,3S)-2,2-dimethyl-3-(2-methylpropa-1-enyl)-cyclopropanecarboxylate (a mixture of four isomers: 1R-trans, 1R:1R-trans, 1S:1R-cis, 1R:1R-cis, 1S4:4:1:1)(d-allethrin), (RS)-α-cyano-3-phenoxybenzyl-(1RS)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate(cypermethrin), 2-methyl-4-oxo-3-(propa-2-inyl)cyclopenta-2-en-1-yl, 2,2-dimethyl-3-(2-methylpropa-1- Selected from the group consisting of enyl)cyclopropanecarboxylate (prallethrin), acetamiprid, azadirachtin, bendiocarb, bifenthrin, boric acid, chlorpyrifos, deltamethrin, diazinon, dichlorovos, eugenol, fipronil, imidacloprid, linalool, malathion, maltodextrin, metofluthrin, nicotine, permethrin, pyrethrin and pyrethroid compounds, rotenone, silicon dioxide (diatomaceous earth), S-methoprene, spinosad (spinosine A), spinosine D, tetramethrin, transfluthrin, and mixtures thereof.

[0047] In a particular embodiment, the arthropod control auxiliary component is included in an amount of 0.02 to 80% by weight, more preferably 0.05 to 70% by weight, and even more preferably 0.1 to 60% by weight, based on the total weight of the composition. Therefore, the composition is interpreted as containing the arthropod control auxiliary component in a minimum amount of at least 0.2% by weight, at least 0.05% by weight, or at least 0.1% by weight, and a maximum amount of 80% by weight or less, 70% by weight or less, or 60% by weight or less, based on the total weight of the composition.

[0048] In special embodiments, within the limits on the amount of substance in the composition as described above, the substance and arthropod control aid in the composition of the present invention are included in the composition in a weight range of 90:10 to 10:90, preferably in a weight range of 80:20 to 20:80, more preferably in a weight range of 65:35 to 35:65, and most preferably in a weight range of 60:40 to 40:60. Here again, the substance and arthropod control aid may be included in the composition in any combination of weight ranges as described above herein, for example, 90:10 to 20:80, preferably 35:65, more preferably 40:60, 80:20 to 10:90, preferably 35:65, even more preferably 40:60, 65:35 to 10:90, preferably 20:80, more preferably 40:60 or 40:60 to 10:90, preferably 20:80, more preferably 35:65.

[0049] In one embodiment, the arthropod control composition may further contain fragrance components. The fragrance components contribute to, modify, enhance, or improve the olfactory properties of the composition, but are interpreted as not contributing to, enhancing, or improving the arthropod control effect of the composition.

[0050] The arthropod control composition may further include a carrier. “Carrier” is interpreted as a material that mixes or prepares the active compound to facilitate its application to the site or other object to be treated, or to facilitate its storage, transport, and / or handling. The carrier may be inorganic, organic, or synthetic of natural origin. The carrier may be liquid or solid.

[0051] Examples of liquid carriers include, but are not limited, emulsions, i.e., solvents and surfactants, or solvents commonly used in fragrance production. A detailed description of the properties and types of solvents is generally not exhaustive. However, examples of solvents that are not limited to these include butylene glycol or propylene glycol, glycerol, dipropylene glycol and its monoethers, 1,2,3-propanetriyltriacetate, dimethylglutarate, dimethyladipate, 1,3-diacetyloxypropane-2-ylacetate, diethylphthalate, isopropyl myristrate, benzyl benzoate, benzyl alcohol, 2-(2-ethoxyethoxy)-1-ethanol, triethyl citrate, 2-methylpropane-1-ene and 2-(2-ethoxyethoxy)ethanol or mixtures thereof, with dipropylene glycol, 2-methylpropane-1-ene and 2-(2-ethoxyethoxy)ethanol and mixtures thereof being particularly suitable.

[0052] For compositions containing both carriers, other suitable carriers other than those specified above may include ethanol, water / ethanol mixtures, limonene or other terpenes, isoparaffins as known under the trademark Isopar (supplied by Exxon Chemical), glycol ethers and glycol ether esters as known under the trademark Dowanol (supplied by Dow Chemical Company), or hydrogenated castor oil as known under the trademark Cremophor RH 40 (supplied by BASF).

[0053] The term "solid carrier" refers to a material that can chemically or physically bond an arthropod control composition or several elements of an arthropod control composition. Generally, such solid carriers are used to stabilize a composition or to control the evaporation rate of a composition or several components. The use of solid carriers is still practiced in the art, and those skilled in the art know how to achieve the desired effect. However, non-limiting examples of solid carriers include absorbent gums or polymers or inorganic materials, such as porous polymers, cyclodextrins, wood-based materials, organic or inorganic gels, clays, gypsum, talc, or zeolites.

[0054] Other non-limiting examples of solid carriers include encapsulation materials. Examples of such materials include wall-forming and plasticizing materials, such as monosaccharides, disaccharides or trisaccharides, natural or modified starches, hydrophilic colloids, cellulose derivatives, polyvinyl acetate, polyvinyl alcohol, proteins or pectin, or materials cited in references such as H. Scherz, Hydrophilic Colloids: Stabilizers, Thickeners and Gelling Agents in Food (Hydrokolloide: Stabilisatoren, Dickungs- und Geliermittel in Lebensmitteln), Band 2 der Schriftenreihe Lebensmittelchemie, Lebensmittelqualitaet, Behr's Verlag GmbH & Co., Hamburg, 1996. Encapsulation is carried out by methods well known to those skilled in the art, for example, using techniques such as spray drying, agglomeration or extrusion; or it may consist of coating encapsulation including coacervation and complex coacervation techniques.

[0055] As non-limiting examples of solid supports, in particular, core-shell capsules using resins of the type aminoplast, polyamide, polyester, polyurea, or polyurethane (all of the above resins are well known to those skilled in the art) and employing techniques such as polymerization, interfacial polymerization, coacervation, or phase separation processes induced by all of the above (all of the above techniques are described in the prior art), optionally in the presence of a polymer stabilizer or a cationic copolymer.

[0056] The resin may be produced by polycondensation of aldehydes (e.g., formaldehyde, 2,2-dimethoxyethanal, glyoxal, glyoxylic acid, or glycolaldehyde and mixtures thereof) with amines such as urea, benzoguanamine, glycoluryl, melamine, methylolmelamine, methylated methylolmelamine, guanazole, and mixtures thereof. Alternatively, pre-molded resins of alkylolated polyamines available on the market under the trademarks Urac® (supplied by Cytec Technology Corp.), Cymel® (supplied by Cytec Technology Corp.), Urecoll®, or Luracoll® (supplied by BASF) may be used.

[0057] Other resins are produced by polycondensation of polyols such as glycerol with hexamethylene diisocyanate trimers, isophorone diisocyanate or xylylene diisocyanate trimers, or hexamethylene diisocyanate biuret or xylylene diisocyanate trimers having trimethylolpropane (known by the trademark Takenate®, supplied by Mitsui Chemicals), particularly polyisocyanates such as xylylene diisocyanate trimers having trimethylolpropane and hexamethylene diisocyanate biuret.

[0058] Some important literature on encapsulation by polycondensation of amino resins, i.e., melamine-based resins, with aldehydes includes those cited in publications such as K. Dietrich et al. Acta Polymerica, 1989, vol. 40, pages 243, 325 and 683, and 1990, vol. 41, page 91. Such literature already describes a variety of parameters affecting the preparation of such core-shell microcapsules according to prior art methods, which are further described and illustrated in patent documents. U.S. Patent No. 4396670 to Wiggins Teape Group Limited is a suitable early example of the latter. Since then, many other authors have enriched the literature in this field, and while it is impossible to cover all developments presented here, general knowledge in encapsulation techniques is extremely important. More recent and relevant publications disclosing appropriate uses of such microcapsules are, for example, the article in HYLee et al. Journal of Microencapsulation, 2002, vol. 19, pages 559-569, the international patent publication International Publication No. 01 / 41915, or the article in S. Bone et al. Chimia, 2011, vol. 65, pages 177-181.

[0059] The present invention also relates to a method for controlling arthropods, preferably insects, which includes bringing arthropods, preferably insects, into direct contact with or into contact with vapors of the compositions described above.

[0060] To clarify, the arthropod control compositions according to the present invention can be applied to the air, to the surface of an article, to the air near the surface of an article, or to the surface of a subject by conventional methods known in the art, such as spraying, coating, wearing, or diffusion.

[0061] In a particular embodiment, the arthropod control composition according to the present invention is applied to the surface of an article, to the air near the surface of an article, or to the surface of an animal or subject.

[0062] In a particular embodiment, the articles may be arthropod control articles such as those described below, and in particular may be candles, coils, electric diffusers, wristbands, patches, collars, ear tags, clothing, fabrics, paper, biochar, cardboard, cellulose pads, mosquito nets, screens, curtains, furniture, paint, walls, ground, sprays, aerosols, creams, roll-ons, wristbands, lotions, soaps, shampoos, sunscreens, laundry powders, liquid detergents, sprays, lotions, and powders.

[0063] In a particular embodiment, the surface of the test subject is the surface of a human or animal test subject, preferably the surface is that of a human test subject, i.e., the skin of a human test subject.

[0064] The present invention also relates to the use of the compositions specified above for controlling arthropods, preferably insects.

[0065] The present invention also relates to an arthropod control article comprising the arthropod control composition described above.

[0066] "Arthropod control article" is interpreted to mean a consumer product that imparts at least an arthropod control effect to the surface or space to which it is applied (e.g., skin, hair, textiles, or building surfaces). In other words, the arthropod control article according to the present invention is a consumer product comprising a functional formulation corresponding to a desired consumer product, as well as optional additional beneficial agents, and at least one arthropod control amount of these substances. For clarity, the above consumer product is a non-food product.

[0067] The nature and types of components of consumer products are not exhaustive and are not guaranteed to be described in more detail here, and can be selected by those skilled in the art based on general knowledge and in accordance with the nature of the product and the desired effect.

[0068] Appropriate consumer products include, but are not limited to, perfumes such as fine perfumes, splash perfumes or eau de parfums, colognes or shave lotions or aftershave lotions or creams or gels; fabric care products such as liquid or solid detergents, laundry powders, fabric softeners, liquid or solid scent boosters, fabric refreshers, ironing water, paper, bleach, carpet cleaners, curtain care products; body care products such as hair care products (e.g., shampoos, coloring solutions or hairsprays, color care products, hair styling products), dental care products, disinfectants, intimate care products; cosmetics (e.g., skin creams or lotions, vanishing creams or deodorants or antiperspirants (e.g., sprays or roll-ons), hair removers, sunscreens or sun products or after-sun products, nail products, skin cleansers, makeup); or skincare products (e.g., soaps, showers or bath mousses, oils or gels, or hygiene products). Foot care / hand care products; air care products, e.g., air fresheners or "ready-to-use" powder air fresheners that can be used in home spaces (rooms, refrigerators, cupboards, shoes or cars) and / or public spaces (halls, hotels, malls, etc.); or home care products, e.g., mold removers, furniture care products, wipes, dish soap or cleaners for hard surfaces (e.g., floors, bathrooms, sanitary products or window cleaning); leather care products; car care products, e.g., polishes, waxes or plastic cleaners; candles; sprays, coils, electric diffusers, diffusers, rubber septums, wristbands, patches, collars, ear tags, clothing, fabrics, paper, biochar, cardboard, cellulose pads, mosquito nets, screens, curtains, varnish or paint, more preferably including candles, sprays, coils, electric diffusers, diffusers, rubber septums, wristbands, patches, collars, ear tags, clothing, fabrics, paper, biochar, cardboard, cellulose pads, mosquito nets, screens, curtains, varnish or paint.

[0069] In a preferred embodiment of the present invention, the consumer product is an electric diffuser. In this embodiment of the present invention, the substance in the arthropod, preferably insect, control composition is present in a specific amount.

[0070] Therefore, when the consumer product is an electric diffuser, the substances are (2E)-3,7-dimethylocta-2,6-dienal; chromen-2-one; 2-methoxy-4-[(E)-propa-1-enyl]phenol; (5R)-2-methyl-5-propa-1-en-2-ylcyclohexa-2-en-1-one; (4-methoxyphenyl)methyl acetate; 2-methyl-3-(4-propan-2-ylphenyl)propanal; (4-methoxyphenyl)methanol; 2-phenylethanol; 4-hydroxy-3-methoxybenzaldehyde; spearmint oil (Mentha spicata oil); clove oil (Syzygium aromaticum) Selected from the list consisting of oil; 5-pentyloxollan-2-one; (1S,6R)-3,7,7-trimethylbicyclo[4.1.0]hepta-3-ene; (4-methoxyphenyl)methyl acetate; and 2-phenylethyl 2-methylpropanoate.

[0071] Furthermore, when the consumer product is an electric diffuser, the following amounts are preferred as a total percentage of the diffuser liquid: (2E)-3,7-dimethylocta-2,6-dienal, 100% or less; chromen-2-one, 33% or less; 2-methoxy-4-[(E)-propa-1-enyl]phenol, 100% or less; (5R)-2-methyl-5-propa-1-en-2-ylcyclohexa-2-en-1-one, 16.9% or less; (4-methoxyphenyl)methyl acetate, 20% or less; 2-methyl-3-(4-propan-2-ylphenyl)propanal, 15.6% or less; (4-methoxyphenyl)methanol, 13.8% or less; 2-phenylethanol, 20% or less; 4-hydroxy-3-methoxybenzaldehyde, 20% or less; spearmint oil (Mentha spicata) oil), 9% or less; clove oil (Syzygium aromaticum oil), 9% or less; 5-pentyloxollan-2-one, 20% or less; (1S,6R)-3,7,7-trimethylbicyclo[4.1.0]hepta-3-ene, 20% or less; (4-methoxyphenyl)methyl acetate, 20% or less; 2-phenylethyl 2-methylpropanoate, 20% or less.

[0072] Some of the consumer products mentioned above may be aggressive to the components of the substance, and therefore may need to be protected from premature degradation by, for example, encapsulation or by chemical bonding with other chemicals suitable for releasing the components of the invention through appropriate external stimuli such as enzymes, light, heat, or pH changes.

[0073] Examples The present invention will be described in more detail by the following embodiments.

[0074] 1. Description of the Arthropod Control Assay Arthropod repellency is tested using in vitro and in vivo test methods as described herein.

[0075] 1.1. In vitro thermodynamic assay of mosquito-like insects Aedes aegypti is a model organism for control trials and is one of the model organisms recommended by the World Health Organization (WHO) because it is an extremely aggressive and anthropogenic mosquito species that generally shows low susceptibility to arthropod control compounds.

[0076] The mosquito control effect of the composition according to the present invention was evaluated using an adapted warm body assay, as specified in Kroeber T, Kessler S, Frei J, Bourquin M, Guerin PM. 2010, An in vitro assay for testing mosquito controlling compounds employing a warm body and carbon dioxide as a behavioral activator, J Am Mosq Control Assoc. 26:381-386. In this in vitro assay, the number of mosquitoes landing on a warm body simulating an attractive host treated with the tested irritant was measured to evaluate the repellent effect.

[0077] The published protocol is adapted for automatic counting using automated counting software, rather than for manually counting stationary mosquitoes. The switch from Anopheles gambiae to Aedes aegypti resulted in a reduction in the number of mosquitoes placed in the tested cages due to the size difference (i.e., 30 mosquitoes instead of 50) and an increase in lighting (i.e., 150 lux instead of 4 lux) because Aedes aegypti are diurnal mosquitoes.

[0078] Furthermore, the inventors were interested in evaluating whether spatial repellency was added to the inhibitory effect, and therefore applied the substance using two different techniques. Similar to Kroeber et al. (2010), these substances were applied to a sandblasted glass petri dish placed on top of a heating element to investigate both inhibitory and repellent effects (i.e., effects similar to most body care applications such as lotions). To investigate spatial repellency only (i.e., effects similar to most home care applications such as liquid electric dispensers), these substances were introduced into a cage space by a forced evaporation system as described in Chappuis C JF, Niclass Y, Vuilleumier C, Starkenmann C. 2015. Quantitative Headspace Analysis of Selected Odorants from Latrines in Africa and India. Environ. Sci. Technol. 49:6134-6140.

[0079] As described by Kroeber et al. (2010), fasted females 10–12 days old, with free access to a 10% sugar solution but no blood, were selected for this assay. For each substance tested, at least three different concentrations were evaluated, ranging from 0.0016% to 1% in ethanol for inhibitory and repellent assessments, and from 0.001 mg / mL to 100 mg / mL in propylene glycol for spatial repellent assessments.

[0080] 1.2. In vivo arm-in-cage assay for insects such as mosquitoes. The arm-in-the-box method was adopted from the WHO guidelines for testing the efficacy of mosquito repellents on human skin (WHO / CDS / NTD / WHOPES / 2009.4). Preparation of 100 hungry female Aedes aegypti mosquitoes for the study was evaluated by inserting an untreated arm into a cage (40 × 40 × 40 cm) for 30 seconds (negative control) three times (once initially, once at 4 hours, and once at 8 hours) to determine probing activity. The product was then applied to the skin of human volunteers' forearms (600 cm²). 2 (1 mL per arm) was administered, and after 5 minutes, the arm was inserted into the cage and exposed for 3 minutes. This assay was performed on three different volunteers in a room controlled to a temperature of 27 ± 2 °C and humidity of 80 ± 10% RH.

[0081] 1.3. In-vitro heating plate assay for arachnids such as ticks The repellent effects of various substances were evaluated against the castor bean tick Ixodes ricinus L, which can transmit both bacterial and viral pathogens. The tick (Ixodes ricinus) is one of the recommended model organisms mentioned in the guidance of the European Biological Products Regulation [Vol II, Efficacy - Assessment & Evaluation (Parts B+C), v. 3.0, April 2018]. Repellent effects were observed in nymphs at the final stage.

[0082] This repellent effect was evaluated using the in-vitro warm plate assay protocol specified in Kroeber T, Bourquin M, Guerin PM. 2013. A standardized in vivo and in vitro test method for evaluating tick repellents. Pestic. Biochem. Phys. 107(2):160-168.

[0083] 2. Evaluation of the arthropod control effect of the present invention 2.1. Results of in vitro thermoassays on mosquito-like insects 2.1.1. Results of in vitro assays for restraint and spatial avoidance Heating element (28.3cm 2 100 μL of the substance, diluted to different concentrations in ethanol, was applied to sandblasted glass petri dishes covering the irrigation surface. The number of mosquitoes that landed on the heat source was counted for N,N-diethyl-3-methylbenzamide (DEET) and ethyl 3-[acetyl(butyl)amino]propanoate (IR3535) used as benchmarks for each irritant, and for pure ethanol as a control.

[0084] All substances tested induced a clear decrease in the number of mosquitoes landed in association with increasing doses applied. At a concentration of 0.04%, two substances (chromen-2-one and 4-hydroxy-3-methoxybenzaldehyde) showed similar numbers of landed mosquitoes to DEET, landing fewer than 10 mosquitoes overall. All additive substances tested were comparable in efficiency to the second benchmark, IR3535, landing approximately 10 mosquitoes per minute at this concentration of 0.04% (Table 1). At a higher concentration of 1%, all seven substances tested showed similar numbers of landed mosquitoes to DEET and lower numbers of landed mosquitoes than IR3535, landing fewer than 2 mosquitoes per minute (Table 1). [Table 1]

[0085] All substances tested induced a clear decrease in the number of mosquitoes landed, correlated with increasing doses applied. At a concentration of 0.04%, two substances (4-ethenyl-2-methoxyphenol and (3Z)-3-butylidene-2-benzofuran-1-one) landed fewer than 10 mosquitoes overall, similar to DEET. Most of the additional substances tested were comparable in efficiency to the second benchmark, IR3535, at this concentration of 0.04%, landing approximately 10 mosquitoes per minute (Table 2). At a higher concentration of 1%, six of the eight substances tested landed similar numbers of mosquitoes to DEET and fewer than 3 mosquitoes per minute, lower than IR3535 (Table 2). [Table 2]

[0086] All substances tested induced a clear decrease in the number of stuns associated with increasing doses applied. At a concentration of 0.04%, three substances (methyl 2-(3-oxo-2-penta-2-enylcyclopentyl)acetate, 6-pentyloxan-2-one, and 3,4,4a,5,6,7,8,8a-octahydrochromen-2-one) showed a number of stuns comparable to DEET, with fewer than 10 stuns in total. At this same concentration of 0.04%, three other irritants (2-methoxy-4-[(E)-propa-1-enyl]phenol, (4R)-4-(2-methoxypropan-2-yl)-1-methylcyclohexene) and clove oil (Syzygium aromaticum oil) showed a number of stuns comparable to IR3535, with approximately 10 stuns per minute (Table 3). At a higher concentration of 1%, nine of the twelve substances tested showed a similar number of mosquito landings as DEET and a lower number than IR3535, which landed fewer than three mosquitoes per minute. 3,7,7-trimethylbicyclo[4.1.0]hepta-3-ene and (4-methoxyphenyl)methyl acetate showed similar repellent results to IR3535 at this 1% concentration, but 1% peppermint oil (Mentha piperita oil) resulted in an 80% reduction in mosquito landings (Table 3). [Table 3]

[0087] As can be seen from the data in Figure 1, similar results were observed when the aforementioned irritants were tested at additional concentrations.

[0088] 2.1.2. Results of in vitro assays on spatial aversion The forced evaporation system allows the cage volume to be filled with the tested irritants (2-methyl-4-oxo-3-propa-2-inylcyclopenta-2-en-1-yl)2,2-dimethyl-3-(2-methylpropa-1-enyl)cyclopropane-1-carboxylate (prallethrin) and N,N-diethyl-3-methylbenzamide (DEET) used as a benchmark. To limit the potential dead volume in the cage, the cage was flushed five times before starting a two-minute test to count the number of mosquitoes that landed.

[0089] As with these two benchmarks, the effect of all substances avoiding stopping on the heating element increased in a dose-response manner, with the exception of 3,7-dimethylocta-2,6-dienal, which similarly reduced stopping by approximately 67% at all concentrations tested. A two-thirds reduction in stopping was observed for most substances tested at a dose of 0.0017 μg / L air. For all substances tested, the number of stopping episodes decreased, reaching less than 5 stopping episodes per minute at doses of 1.7 and / or 17 μg / L air (Table 4). [Table 4]

[0090] For all substances, a decrease in the number of stops was observed in relation to the increasing amount of the substance present in the cage air. For four substances (grape leaf oil (cognac oil green), 4-ethenyl-2-methoxyphenol, (E)-1-(2,6,6-trimethylcyclohexa-2-en-1-yl)buta-2-en-1-one, and 6-hexyloxan-2-one), it was shown that fewer than 5 stops occurred within 2 minutes at a low dose of 0.17 μg / L of air. With the exception of 3-butylidene-2-benzofuran-1-one, all other substances reached a level of 90% repel rate at doses of 1.7 and / or 17 μg / L of air. (E)-1-(2,6,6-trimethylcyclohexa-2-en-1-yl)buta-2-en-1-one was particularly effective, as it had a repel rate of over 80% at all five concentrations tested (Table 5). [Table 5]

[0091] For all substances, a decrease in the number of stops was observed in relation to an increase in the amount of the substance present in the cage air. However, this decrease was very small for some substances, such as 2-phenylethanol, with stops reduced by 41% at the maximum dose tested. In contrast, some substances performed very well, with stops reduced by more than 90% at a dose of 0.017 μg / μL (Table 6). [Table 6]

[0092] These dose-response patterns can be clearly visualized from the data shown in Figure 2.

[0093] 2.2. Results of in vivo arm-in-cage assay for insects such as mosquitoes The arm-in-cage test is a mandatory assay for most biocide registrations to evaluate the effectiveness of a substance. This involves a volunteer's treated arm being subjected to 3125 bloodthirsty mosquitoes / airborne insects. 3This is an extremely challenging test because it involves being placed in a space containing a high density of material. The test involves the skin of the arms of three different volunteers (600cm²). 2 Despite the application of 20% 4-hydroxy-3-methoxybenzaldehyde to the arm, the percentage of mosquitoes landing on the arm decreased by 82±5.2%, 78±2.6%, 66±8.0%, 61±6%, and 63±2% at different test times after application (5 min, 1 h, 2 h, 3 h, and 4 h, respectively).

[0094] Similarly, other compounds also exhibited related repellent effects, with 6-pentyloxan-2-one, in particular, maintaining approximately 75% repellency beyond 4 hours (data provided in Figure 3).

[0095] 2.3. Results of in-vitro heat plate assay for arachnids such as ticks If ticks exhibit a preset negative geotaxis response in an in vitro assay, this indicates that the tested substance does not prevent ticks from crawling up in nature to find a suitable attachment site for blood feeding. Therefore, the average percentage of ticks affected by three concentrations of the substance diluted in ethanol was measured for 12–24 ticks, using ethyl 3-[acetyl(butyl)amino]propionate (IR3535) as a benchmark and pure ethanol as a control. A clear biological dose-response was measured, i.e., the number of ticks affected by each substance increased with the amount of the substance applied. The most efficient tested substances were chromene-2-one and 5-pentyloxollan-2-one, both of which provided a response comparable to the benchmark IR3535 at the three concentrations tested. Even the least efficient substance was effective at the highest concentration tested (1% 25 μg / cm³). 2 This resulted in a reduction of over 50% in the number of ticks crawling up in search of food (Table 7). [Table 7]

[0096] 3-Butylidene-2-benzofuran-1-one showed greater tick repellency than the benchmark compound IR3535, namely, at the lowest dose tested (0.04%), more than 3 / 4 of the ticks were affected, and at the intermediate dose tested (0.2%), all the ticks tested were affected and stopped seeking food. All other substances showed a dose-response effect for tick repellency, reaching a minimum of 50% repellency when tested at 1%. 4-Ethenyl-2-methoxyphenol also showed a maximum concentration of 1% (25 μg / cm³). 2 As a result, all the ticks tested avoided crawling up in search of food (Table 8). [Table 8]

[0097] Both substances tested reduced the percentage of ticks crawling up in search of food. The percentage of this repellent effect was 0.2% and 1% (5 and 25 μg / cm³, respectively). 2 It was equivalent to the benchmark IR3535 at the highest dose tested (Table 9). [Table 9]

Claims

1. (E)-1-(2,6,6-trimethylcyclohexa-2-en-1-yl)buta-2-en-1-one, (3Z)-3-butylidene-2-benzofuran-1-one, 4-ethenyl-2-methoxyphenol, grape leaf oil (cognac oil green), labdanum extract (Cistus spp.), 5-pentyloxolan-2-one, chromen-2-one, (2E)-3,7-dimethylocta-2,6-dienal, 4-hydroxy-3-methoxybenzaldehyde, (5R)-2-methyl-5-propa-1-en-2-ylcyclohexa-2-en-1-one, spearmint oil (Mentha spicata) [oil], 6-hexyloxan-2-one, 5-methyl-2-propane-2-ylcyclohexyl acetate, Nigella damascena oil, 2-phenylethanol, 6-pentyloxan-2-one, (4-methoxyphenyl)methyl acetate, Syzygium aromaticum oil, 3,4,4a,5,6,7,8,8a-octahydrochromen-2-one, (1S,6R)-3,7,7-trimethylbicyclo[4.1.0]hepta-3-ene, 2-phenylethyl 2-methylpropanoate, methyl 2-(3-oxo-2-penta-2-enylcyclopentyl) acetate, (4R)-4-(2-methoxypropane-2-yl)-1-methylcyclohexene, Mentha piperita oil An arthropod control composition, preferably an insect control composition, comprising one or more substances selected from the group consisting of oil, 2-methoxy-4-[(E)-propa-1-enyl]phenol, 2-methyl-3-(4-propan-2-ylphenyl)propanal, and (4-methoxyphenyl)methanol.

2. The arthropod control composition according to claim 1, wherein the arthropod is an insect, preferably a mosquito.

3. The substances used for repellent purposes, more preferably for mosquito repellent purposes, include labdanum extract, cognac oil green, (3Z)-3-butylidene-2-benzofuran-1-one, 2-methyl-3-(4-propane-2-ylphenyl)propanal, methyl 2-(3-oxo-2-penta-2-enylcyclopentyl) acetate, Nigella damascena oil, (2E)-3,7-dimethylocta-2,6-dienal, 5-pentyloxolan-2-one, and clove oil (Syzygium aromaticum). The arthropod control composition according to claim 1 or 2, selected from oil, 4-ethenyl-2-methoxyphenol, 4-hydroxy-3-methoxybenzaldehyde, 6-pentyloxan-2-one, (1S,6R)-3,7,7-trimethylbicyclo[4.1.0]hepta-3-ene, chromen-2-one, 6-hexyloxan-2-one, 2-methoxy-4-[(E)-propa-1-enyl]phenol, 5-methyl-2-propane-2-ylcyclohexyl]acetate, and (4-methoxyphenyl)methanol.

4. The substances used for spatial repellent purposes, preferably for mosquito spatial repellent purposes, include: Cognac oil green, (E)-1-(2,6,6-trimethylcyclohexa-2-en-1-yl)buta-2-en-1-one, 2-methyl-3-(4-propan-2-ylphenyl)propanal, 4-ethenyl-2-methoxyphenol, methyl 2-(3-oxo-2-penta-2-enylcyclopentyl) acetate, 6-hexyloxan-2-one, chromen-2-one, 6-pentyloxan-2-one, peppermint oil (Mentha piperita oil), 4-hydroxy-3-methoxybenzaldehyde, clove oil (Syzygium aromaticum oil), 5-pentyloxolan-2-one, 2-phenylethanol, kuranthes oil (Nigella damascena oil), spearmint oil (Mentha spicata oil) The arthropod control composition according to claim 1 or 2, selected from oil, (5R)-2-methyl-5-propa-1-en-2-ylcyclohexa-2-en-1-one, 2-methoxy-4-[(E)-propa-1-enyl]phenol, (4-methoxyphenyl)methanol, (4R)-4-(2-methoxypropan-2-yl)-1-methylcyclohexene, 2-methoxy-4-[(E)-propa-1-enyl]phenol, and (4-methoxyphenyl)methyl acetate.

5. The arthropod control composition according to claim 1, wherein the arthropod is an arachnid, preferably a tick.

6. The arthropod control composition according to claim 1 or 5, wherein the substance used for restorative purposes, more preferably for tick restorative purposes, is selected from (E)-1-(2,6,6-trimethylcyclohexa-2-en-1-yl)buta-2-en-1-one, 4-ethenyl-2-methoxyphenol, (3Z)-3-butylidene-2-benzofuran-1-one, 5-pentyloxolan-2-one, chromen-2-one, 2-methoxy-4-[(E)-propa-1-enyl]phenol, and 2-methyl-3-(4-propan-2-ylphenyl)propanal.

7. The arthropod control composition according to any one of claims 1 to 6, wherein the arthropod control composition contains the compound or composition in an amount of 0.01 to 90% by weight, more preferably 0.2 to 30% by weight, based on the total weight of the composition.

8. An arthropod control composition according to any one of claims 1 to 7, comprising at least two substances.

9. N,N-diethyl-3-methylbenzamide (DEET), ethylbutylacetylaminopropionate (IR3535); para-menthane-3,8-diol (PMD); 1-(1-methylpropoxycarbonyl)-2-(2-hydroxaethyl)piperidine (icaridin);Cedarwood oil (China), cedarwood oil (Texas), cedarwood oil (Virginia), cinnamon oil, citronella oil, corn mint oil, fractionated hydrated cyclized citronella oil (Cymbopogon winterianus oil), decanoic acid, eucalyptus citriodora oil, hydrated cyclized eucalyptus citriodora oil, eugenol, garlic oil, geraniol, geranium oil, lavender, Lavandula hybrida extract, lavandin oil, lemon oil, lemongrass oil, margosa extract, metofluthrin, mixture of cis- and trans-p-menthane-3,8-diol, N,N-diethyl-methatoluamide, nonanoic acid, rosemary oil, thyme oil, wintergreen oil, 2,3,4,5-bis(butyl-2-ene)tetrahydrofurfural (MGK Repellent) 11) Cineole, cinnamaldehyde, citronellal, citronellol, coumarin, dibutylphthalate, diethylphthalate, dimethylanthranillate, dimethylphthalate, ethyl vanillin, eucalyptus oil, delta-octaractone, delta-nonalactone, delta-decalactone, delta-undecalactone, delta-dodecalactone, gamma-octaractone, gamma-nonalactone, gamma-decalactone, gamma-undecalactone, gamma-dodecalactone, hydroxycitronellal, lime oil, limonene, linalool, methylanthranillol Root, peppermint oil, myrcene, neem oil, sabinene, β-caryophyllene, (1H-indole-2-yl)acetic acid, anethole, anise oil, basil oil, bay oil, camphor, ethyl salicylate, evergreen oil (pine oil), (1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindole-2-yl)methyl, (1R-trans)-2,2-dimethyl-3-(2-methylpropane-1-enyl)cyclopropanecarboxylate (d-tetramethrin), (RS)-3-allyl-2-methyl-4-oxocyclopenta-2-enyl-(1R,3R;1R,3S)-2,2-dimethyl-3-(2-methylpropa-1-enyl)-cyclopropanecarboxylate (a mixture of four isomers: 1R trans, 1R:1R trans, 1S:1R cis, 1R:1R cis, 1S 4:4:1:1) (d-allethrin), (RS)-α-cyano-3-phenoxybenzyl-(1RS)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (cypermethrin), 2-methyl-4-oxo-3-(propa-2-inyl)cyclopenta-2-en-1-yl, 2,2-dimethyl-3-(2-methylpropa-1-enyl)cyclopropanecarboxylate (prallethrin), acetamiprid, azadirachtin, bendiocarb, bifenthrin, boric acid, chlorpyrifo The arthropod control composition according to any one of claims 1 to 8, further comprising an arthropod control auxiliary component selected from the group consisting of S, deltamethrin, diazinon, dichlorovos, eugenol, fipronil, imidacloprid, linalool, malathion, maltodextrin, metofluthrin, nicotine, permethrin, pyrethrin and pyrethroid compounds, rotenone, silicon dioxide (diatomaceous earth), S-methoprene, spinosad (spinosin A), spinosin D, tetramethrin, transfluthrin, and mixtures thereof.

10. A method for controlling arthropods, comprising bringing arthropods, preferably insects, into direct contact with or exposure to vapors of the compositions described in claims 1 to 9.

11. Use of the composition according to any one of claims 1 to 9 for controlling arthropods, preferably insects.

12. An arthropod control article, preferably an insect control article, comprising an arthropod control composition, preferably an insect control composition, according to any one of claims 1 to 9.

13. The arthropod control article according to claim 12, wherein the article is a consumer product.

14. The aforementioned articles include: textile care products, such as liquid or solid detergents, fabric softeners, liquid or solid scent boosters, fabric refreshers, ironing water, paper, bleach, carpet cleaners, and curtain care products; body care products, such as hair care products (e.g., shampoos, coloring preparations or hairsprays, color care products, hair styling products, and dental care products), disinfectants, and intimate care products; cosmetics (e.g., skin creams or lotions, vanishing creams or deodorants or antiperspirants (e.g., sprays or roll-ons), hair removers, sunscreens or sun products or after-sun products, nail products, skin cleansers, and makeup); and skin care products (e.g., soaps, showers or bath mousses, oils or gels, or hygiene products or foot care products). A / hand care product; air care product, e.g., air freshener or "ready-to-use" powder air freshener that can be used in home spaces (rooms, refrigerators, cupboards, shoes or cars) and / or public spaces (halls, hotels, malls, etc.); or home care product, e.g., mold remover, furniture care product, wipes, dish soap or cleaner for hard surfaces (e.g., floors, bathrooms, sanitary products or window cleaning); leather care product; car care product, e.g., polish, wax or plastic cleaner; candle, spray, coil, electric diffuser, diffuser, rubber septum, wristband, patch, collar, ear tag, clothing, fabric, paper, biochar, cardboard, cellulose pad, mosquito net, screen, curtain, varnish or paint, the arthropod control article according to claim 12 or 13.

15. The arthropod control article according to claim 14, wherein the article is an electric diffuser.

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