Puncture catheter

Abstract

To provide a puncture catheter that makes it easier to reduce the amount of fluid used. [Solution] A puncture catheter 100 comprising: a medical puncture needle 1 having a longitudinal direction x and a lumen 1e extending in the longitudinal direction x; a first cylindrical member 10 having a lumen 10e extending in the longitudinal direction x and connected to the puncture needle 1; and a second cylindrical member 20 positioned in the lumen 10e of the first cylindrical member 10 and having a lumen 20e extending in the longitudinal direction x through which liquid passes, and connected to the puncture needle 1, wherein the second cylindrical member 20 has a section 21 having an inner diameter less than or equal to the outer diameter of the puncture needle 1 at the proximal end 1b of the puncture needle 1.

Description

Technical Field

[0001] The present invention relates to a puncture catheter.

Background Art

[0002] For myocardial tissue having cardiomyocytes that are losing function due to myocardial infarction or the like, treatment such as regenerating cardiomyocytes is performed by directly administering a chemical solution such as a cardiomyocyte regeneration cell-containing solution. Thus, when directly administering a chemical solution to an organ in the body, it is necessary to insert a catheter having a needle into the body cavity and puncture the organ with the needle. As a catheter having a needle used in such treatment, for example, the following have been developed.

[0003] Patent Document 1 describes a catheter provided with a fixed piercing element having a spiral structure. This catheter is operated so that the spiral structure of the piercing element is screwed into the heart wall.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, in the catheter described in Patent Document 1, there is a problem that the amount of liquid remaining in the catheter is large, and as a result, the amount of liquid used increases.

[0006] The present invention has been made in view of the above circumstances, and an object thereof is to provide a puncture catheter that can easily reduce the amount of liquid used.

Means for Solving the Problems

[0007] The puncture catheter according to an embodiment of the present invention that solves the above problems is as follows. [1] A medical puncture needle having a longitudinal direction and a lumen extending in the longitudinal direction, A first cylindrical member having a lumen extending in the longitudinal direction and connected to the puncture needle, A second cylindrical member is positioned within the lumen of the first cylindrical member, has a lumen extending in the longitudinal direction through which liquid passes, and is connected to the puncture needle, It has, The second cylindrical member is a puncture catheter having a section at the proximal end of the puncture needle having an inner diameter less than or equal to the outer diameter of the puncture needle.

[0008] The second cylindrical member provided in the above-mentioned puncture catheter has a section with an inner diameter less than or equal to the outer diameter of the puncture needle at the proximal end of the puncture needle, which makes it easier to narrow the path through which the fluid passes. As a result, the amount of fluid remaining in the lumen of the second cylindrical member can be reduced, making it easier to reduce the amount of fluid used.

[0009] The puncture catheter according to the embodiment of the present invention is preferably one of the following [2] to

[15] . [2] The puncture catheter according to [1], wherein the thermal conductivity measured on the inner surface of the second cylindrical member is lower than the thermal conductivity measured on the inner surface of the first cylindrical member. [3] The puncture catheter according to [1] or [2], wherein the second tubular member has lower bending rigidity than the first tubular member. [4] A puncture catheter according to any one of the following [1] to [3], wherein the inner diameter of the second cylindrical member at the first position is greater than the inner diameter of the second cylindrical member at the second position located proximal to the first position. [5] The puncture catheter according to any one of the items [1] to [4], wherein the second cylindrical member has a tapered portion whose outer diameter increases toward the distal end. [6] The puncture catheter according to any one of the items [1] to [5], wherein the inner surface of the first cylindrical member and the outer surface of the second cylindrical member are separated. [7] A puncture catheter according to any one of the following items [1] to [6], wherein a gap exists between the inner surface of the first cylindrical member and the outer surface of the second cylindrical member. [8] The puncture catheter according to any one of [1] to [7], wherein the first connection portion, which is the portion where the first tubular member and the puncture needle are connected, is located distal to the distal end of the second connection portion, which is the portion where the second tubular member and the puncture needle are connected. [9] The puncture catheter according to any one of [1] to [8], wherein the first cylindrical member includes a portion made of a material containing metal, and the second cylindrical member includes a portion made of a material containing resin.

[10] The puncture catheter according to any one of [1] to [9], wherein the first tubular member and the puncture needle are welded together, and the second tubular member and the puncture needle are bonded together with an adhesive.

[11] The puncture catheter according to any one of [1] to

[10] , wherein the inner diameter at the proximal end of the puncture needle is smaller than the inner diameter of the first cylindrical member at the midpoint of the first cylindrical member in the longitudinal direction.

[12] The puncture catheter according to any one of [1] to

[11] , wherein the lumen of the puncture needle and the lumen of the second cylindrical member are in communication, and the lumen of the puncture needle and the lumen of the first cylindrical member are not in communication.

[13] The puncture catheter according to any one of the items [1] to

[12] , wherein the lumen of the second cylindrical member extends in a spiral shape.

[14] The puncture catheter according to any one of [1] to

[13] , wherein the first cylindrical member comprises a metal layer and an outer resin layer disposed on the outer surface of the metal layer.

[15] The puncture catheter according to any one of the items [1] to

[14] , wherein the liquid is a cell-containing fluid. [Effects of the Invention]

[0010] The second cylindrical member provided in the puncture catheter has a section with an inner diameter not exceeding the outer diameter of the puncture needle at the proximal end of the puncture needle, which makes it easier to narrow the path through which the liquid passes. As a result, the amount of liquid remaining in the lumen of the second cylindrical member can be reduced, making it easier to reduce the amount of liquid used.

Brief Description of the Drawings

[0011] [Figure 1] Figure 1 shows a side view of a puncture catheter according to an embodiment of the present invention. [Figure 2] Figure 2 shows a cross-sectional view of the puncture catheter shown in Figure 1. [Figure 3] Figure 3 shows a cross-sectional view taken along line III-III of the puncture catheter shown in Figure 2. [Figure 4] Figure 4 shows a side view of a puncture catheter according to an embodiment of the present invention. [Figure 5] Figure 5 shows a cross-sectional view of the puncture catheter shown in Figure 4. [Figure 6] Figure 6 shows a cross-sectional view taken along line VI-VI of the puncture catheter shown in Figure 5.

Embodiments for Carrying Out the Invention

[0012] One embodiment of the puncture catheter of the present invention has a medical puncture needle having a longitudinal direction and a lumen extending in the longitudinal direction, a first cylindrical member having a lumen extending in the longitudinal direction of the puncture needle and connected to the puncture needle, and a second cylindrical member disposed in the lumen of the first cylindrical member and having a lumen extending in the longitudinal direction of the puncture needle through which the liquid passes and connected to the puncture needle. The gist of the second cylindrical member lies in that it has a section with an inner diameter not exceeding the outer diameter of the puncture needle at the proximal end of the puncture needle.

[0013] Hereinafter, the present invention will be specifically described with reference to the drawings. However, the present invention is not limited to the illustrated examples, and it is also possible to appropriately modify and implement it within the scope that can conform to the gist of the foregoing and following descriptions, and all of them are included in the technical scope of the present invention. In each figure, for the sake of convenience, hatching, reference signs, etc. may be omitted, but in such cases, reference shall be made to the specification and other figures. Also, the dimensions of various components in the drawings may differ from the actual dimensions because priority is given to facilitating the understanding of the features of the present invention.

[0014] Referring to FIGS. 1 to 6, the overall configuration of a puncture catheter according to an embodiment of the present invention will be described. FIGS. 1 and 4 show side views of a puncture catheter according to an embodiment of the present invention. FIG. 2 shows a cross-sectional view of the puncture catheter shown in FIG. 1. More specifically, it shows a cross-section passing through the central axis of the first cylindrical member and parallel to the longitudinal direction of the first cylindrical member. FIG. 3 shows a cross-sectional view taken along line III-III of the puncture catheter shown in FIG. 2. FIG. 5 shows a cross-sectional view of the puncture catheter shown in FIG. 4. More specifically, it shows a cross-section passing through the central axis of the first cylindrical member and parallel to the longitudinal direction of the first cylindrical member. FIG. 6 shows a cross-sectional view taken along line VI-VI of the puncture catheter shown in FIG. 5. In FIGS. 1 to 6, a puncture catheter 100 having a puncture needle 1, a first cylindrical member 10, and a second cylindrical member 20 is shown.

[0015] In this drawing, the longitudinal direction of the puncture needle 1 is indicated by x, the radial direction of the puncture needle 1 is indicated by y, and the circumferential direction of the puncture needle 1 is indicated by c. The radial direction y is a direction perpendicular to the longitudinal direction x. The longitudinal direction x of the puncture needle 1 can also be said to be the extending direction of the puncture needle 1, in other words. For ease of understanding, in this drawing, the longitudinal direction x of the puncture needle 1, the longitudinal direction of the first cylindrical member 10, and the longitudinal direction of the second cylindrical member 20 coincide, the radial direction y of the puncture needle 1, the radial direction of the first cylindrical member 10, and the radial direction of the second cylindrical member 20 coincide, and the circumferential direction c of the puncture needle 1, the circumferential direction of the first cylindrical member 10, and the circumferential direction of the second cylindrical member 20 coincide. However, the present invention is not limited to this aspect.

[0016] In this specification, the proximal side refers to the direction toward the user's hand relative to the longitudinal direction x of the puncture needle 1, and the distal side refers to the opposite side of the proximal side, i.e., the direction toward the treatment target. Furthermore, when each component is divided into two equal parts along the longitudinal direction x of the puncture needle 1, the portion located on the distal side of each component is called the distal part, and the portion located on the proximal side of each component is called the proximal part. The distal end of each component is the end located furthest distally. The proximal end of each component is the end located furthest proximally. The end of each component refers to the portion including the end of each component and its surroundings. That is, the distal end of each component refers to the portion including the distal end of each component and its surroundings, and the proximal end of each component refers to the portion including the proximal end of each component and its surroundings.

[0017] The puncture catheter 100 includes a puncture needle 1, a first cylindrical member 10, and a second cylindrical member 20.

[0018] The puncture needle 1 is for medical use and is used to puncture target tissue. As shown in Figures 1, 2, 4, and 5, the puncture needle 1 has a longitudinal direction x and a lumen 1e extending in the longitudinal direction x. Through this lumen 1e, liquids such as cell-containing fluid or drug solutions can be delivered to the target tissue.

[0019] As shown in Figures 1 to 6, the first cylindrical member 10 is a cylindrical member having a lumen 10e extending in the longitudinal direction x of the puncture needle 1, and is connected to the puncture needle 1.

[0020] As shown in Figures 2, 3, 5, and 6, the second cylindrical member 20 is a cylindrical member positioned in the lumen 10e of the first cylindrical member 10. The second cylindrical member 20 is connected to the puncture needle 1 and has a lumen 20e extending in the longitudinal direction x of the puncture needle 1. Liquids such as cell-containing fluid or drug solution pass through this lumen 20e.

[0021] As shown in Figures 2 and 5, the second cylindrical member 20 has a section 21 having an inner diameter less than or equal to the outer diameter of the puncture needle 1 at its proximal end 1b. As shown in Figure 5, the entire second cylindrical member 20 may have a section 21 having an inner diameter less than or equal to the outer diameter of the puncture needle 1 at its proximal end 1b. As shown in Figure 2, only a part of the second cylindrical member 20 may have a section 21 having an inner diameter less than or equal to the outer diameter of the puncture needle 1 at its proximal end 1b.

[0022] The second cylindrical member 20 provided in the puncture catheter 100 has a section 21 at the proximal end 1b of the puncture needle 1 with an inner diameter less than or equal to the outer diameter of the puncture needle 1, which makes it easier to narrow the path through which the fluid passes. As a result, the amount of fluid remaining in the lumen 20e of the second cylindrical member 20 can be reduced, making it easier to reduce the amount of fluid used.

[0023] From the viewpoint of making it easier to enhance the above effect, as shown in Figures 2 and 5, the second cylindrical member 20 may have a section having an inner diameter less than or equal to the inner diameter of the puncture needle 1 at its proximal end 1b. The entire second cylindrical member 20 may have a section having an inner diameter less than or equal to the inner diameter of the puncture needle 1 at its proximal end 1b. Only a part of the second cylindrical member 20 may have a section having an inner diameter less than or equal to the inner diameter of the puncture needle 1 at its proximal end 1b.

[0024] Furthermore, if the internal shape of the component is other than a perfect circle, the inner diameter of the component shall be the average of the radius of the circle inscribed in the internal shape and the radius of the circle circumscribed in the internal shape. Also, if the outer shape of the component, when viewed from a direction parallel to the longitudinal direction x of the puncture needle 1, is other than a perfect circle, the outer diameter of the component shall be the average of the radius of the circle inscribed in the outer shape and the radius of the circle circumscribed in the outer shape.

[0025] The puncture catheter 100 is used to administer liquids such as cell-containing solutions or drug solutions to target tissues. Specifically, the puncture catheter 100 is preferably used for direct administration to internal organs, such as the heart, kidneys, and liver. The liquid administered using the puncture catheter 100 is preferably a cell-containing solution. For example, the puncture catheter 100 can be used to directly administer iPS cell-containing solutions to the liver or kidneys, or to directly administer myocardial regeneration cell-containing solutions to the heart, or more specifically, the myocardium.

[0026] The puncture needle 1 is preferably designed to puncture internal organs. Internal organs refer to organs located inside the body, particularly in the abdomen and chest, and are also known as viscera.

[0027] The puncture needle 1 can be made of, for example, metal or resin. The puncture needle 1 may be made entirely of metal, or entirely of resin. The puncture needle 1 may be made partly of metal and the other part of resin.

[0028] The puncture needle 1 is preferably made of metal only. Examples of metals that make up the puncture needle 1 include stainless steel such as SUS304 and SUS316, platinum, nickel, cobalt, chromium, titanium, tungsten, gold, Ni-Ti alloy, Co-Cr alloy, or combinations thereof.

[0029] Examples of resins that make up the puncture needle 1 include polyether ether ketone (PEEK) and polycarbonate (PC). By constructing the puncture needle 1 using only resin and no metal, the puncture needle 1 can be used even in patients with metal allergies.

[0030] The puncture needle 1 may have a distal end 1a and a proximal end 1b. The puncture needle 1 may have an inner surface 1c facing the lumen 1e of the puncture needle 1 and an outer surface 1d facing the outside of the puncture needle 1.

[0031] The length of the puncture needle 1 in the longitudinal direction x can be 2 mm or more, 3 mm or more, 4 mm or more, etc. The length of the puncture needle 1 in the longitudinal direction x can be 50 mm or less, 30 mm or less, 10 mm or less, etc. The length of the puncture needle 1 in the longitudinal direction x refers to the longest length of the puncture needle 1 in the longitudinal direction x. When used as a puncture catheter for puncturing the myocardium, the length of the puncture needle 1 in the longitudinal direction x is preferably 5 mm.

[0032] The length of the puncture needle 1 in the radial direction y can be 0.2 mm or more, 0.3 mm or more, 0.4 mm or more, etc. The length of the puncture needle 1 in the radial direction y can be 10 mm or less, 5 mm or less, 1 mm or less, etc. The length of the puncture needle 1 in the radial direction y refers to the longest length of the puncture needle 1 in the radial direction y. When used as a puncture catheter for puncturing the myocardium, the length of the puncture needle 1 in the radial direction y is preferably 0.45 mm.

[0033] As shown in Figures 4 and 5, the puncture needle 1 may have a cylindrical member 2 and a spiral member 3.

[0034] The tubular member 2 is a tubular member and may have a lumen 2e extending in the longitudinal direction x of the puncture needle 1. This lumen 2e corresponds to the lumen 1e of the puncture needle 1. Through this lumen 2e, liquids such as cell-containing fluid or drug solutions can be delivered to the target tissue. The tubular member 2 may have a distal end 2a and a proximal end 2b.

[0035] The helical member 3 is preferably a member in which a wire 4 is wound in a helical shape. The wire 4 is preferably wound around the cylindrical member 2.

[0036] Regarding the puncture needle 1, by adopting a design in which a spiral member 3 is arranged around a cylindrical member 2, it becomes easier to screw the puncture needle 1 into the target tissue by rotating the puncture needle 1 around the cylindrical member 2 as an axis. This makes it easier to puncture the target tissue with the puncture needle 1. In addition, the wire 4 that makes up the spiral member 3 bites into the tissue, making it difficult for the puncture needle 1 to come out of the tissue. Furthermore, the puncture depth can be easily adjusted by adjusting the rotation of the puncture needle 1.

[0037] It is preferable that a hole 5 is formed in the puncture needle 1, connecting the lumen 1e of the puncture needle 1 to the outside of the puncture needle 1. Liquids such as cell-containing fluid or drug solution that have been transported through the lumen 1e are delivered to the target tissue through this hole 5.

[0038] The puncture needle 1 may have only one hole 5 or multiple holes 5. If only one hole 5 is formed on the puncture needle 1, it becomes easier to administer liquids such as cell-containing fluid or drug solutions to a specific point. If multiple holes 5 are formed on the puncture needle 1, it becomes easier to administer liquids such as cell-containing fluid or drug solutions to a wider area.

[0039] When observed from a direction perpendicular to the longitudinal direction x of the puncture needle 1, the outer shape of the hole 5 can be a polygon such as a triangle, square, or pentagon, or a circle, an ellipse, or a combination thereof. Polygons include not only those with clearly defined corner vertices and straight sides, but also rounded polygons with rounded corners, and those with at least some of their sides being curved.

[0040] The first cylindrical member 10 may have a distal end 10a and a proximal end 10b. Preferably, the first cylindrical member 10 is connected to the proximal end of the puncture needle 1. More preferably, the distal end of the first cylindrical member 10 is connected to the proximal end of the puncture needle 1.

[0041] It is preferable that the lumen 1e of the puncture needle 1 and the lumen 10e of the first cylindrical member 10 are not in communication with each other.

[0042] Preferably, the first cylindrical member 10 has an inner surface 10c facing the inner lumen 10e of the first cylindrical member 10 and an outer surface 10d facing the outside of the first cylindrical member 10.

[0043] The method of connecting the first cylindrical member 10 and the puncture needle 1 is not particularly limited. Examples include fixing by welding, welding, bonding, crimping, etc. Among these, it is preferable that the first cylindrical member 10 and the puncture needle 1 are welded together.

[0044] The first cylindrical member 10 may consist of only one cylindrical member, or it may consist of multiple cylindrical members.

[0045] The first cylindrical member 10 can be made of resin, metal, or the like. The first cylindrical member 10 may be made entirely of metal, or entirely of resin. The first cylindrical member 10 may be made partly of metal and the other part of resin.

[0046] Examples of metals that make up the first cylindrical member 10 include stainless steel such as SUS304 and SUS316, platinum, nickel, cobalt, chromium, titanium, tungsten, gold, Ni-Ti alloy, Co-Cr alloy, or combinations thereof.

[0047] Examples of resins constituting the first cylindrical member 10 include synthetic resins such as polyolefin resins (e.g., polyethylene and polypropylene), polyamide resins (e.g., nylon), polyester resins (e.g., PET), aromatic polyetherketone resins (e.g., PEEK), polyetherpolyamide resins, polyurethane resins, polyimide resins, and fluororesins (e.g., PTFE, PFA, ETFE), or combinations thereof.

[0048] The first cylindrical member 10 preferably includes a portion made of a material containing metal. Only a portion of the first cylindrical member 10 may be made of metal, or the entire first cylindrical member 10 may be made of metal.

[0049] As shown in Figures 2 to 6, it is preferable that the first cylindrical member 10 has a metal layer 11 made of metal. Having a metal layer 11 in the first cylindrical member 10 makes it easier to create a puncture catheter 100 with high torque transmission capabilities.

[0050] Preferably, the metal layer 11 has an inner surface 11c located on the radially inward side of the first cylindrical member 10 and an outer surface 11d located on the radially outward side of the first cylindrical member 10.

[0051] The metal layer 11 may consist of a pipe, a coil around which wire is wound, a braid in which wire is woven, a pipe with holes or grooves formed therein, or a combination thereof.

[0052] It is preferable that the metal layer 11 has multiple grooves 11f formed therein. The grooves 11f may be closed grooves or through grooves. Both through grooves and closed grooves may be formed in the metal layer 11. By combining through grooves and closed grooves, or by selecting one or the other, it becomes easier to create a metal layer 11 with the desired flexibility and rigidity.

[0053] As shown in Figures 2 and 3, it is preferable that the first cylindrical member 10 has an outer resin layer 12 disposed on the outer surface 11d of the metal layer 11. This makes it less likely for the first cylindrical member 10 to get caught on the body cavity wall, even if holes or grooves 11f are formed in the metal layer 11, and makes it easier to ensure insertion within the body cavity.

[0054] The outer resin layer 12 may be positioned to cover only a portion of the outer surface 11d of the metal layer 11. Alternatively, the outer resin layer 12 may be positioned to cover the entire outer surface 11d of the metal layer 11.

[0055] As shown in Figures 5 and 6, the first cylindrical member 10 may have an inner resin layer 13 disposed on the inner surface 11c of the metal layer 11.

[0056] The inner resin layer 13 may be positioned to cover only a portion of the inner surface 11c of the metal layer 11. Alternatively, the inner resin layer 13 may be positioned to cover the entire inner surface 11c of the metal layer 11.

[0057] Although not shown in the figures, the first cylindrical member 10 may have both an outer resin layer 12 placed on the outer surface 11d of the metal layer 11 and an inner resin layer 13 placed on the inner surface 11c of the metal layer 11.

[0058] The inner diameter at the proximal end 1b of the puncture needle 1 is preferably smaller than the inner diameter of the first cylindrical member 10 at the midpoint of the first cylindrical member 10 in the longitudinal direction x of the puncture needle 1. By making the inner diameter of the first cylindrical member 10 relatively large, the operability of the puncture catheter 100 can be easily improved.

[0059] The second cylindrical member 20 may have a distal end 20a and a proximal end 20b. Preferably, the second cylindrical member 20 is connected to the proximal end of the puncture needle 1. More preferably, the distal end of the second cylindrical member 20 is connected to the proximal end of the puncture needle 1.

[0060] It is preferable that the lumen 1e of the puncture needle 1 and the lumen 20e of the second cylindrical member 20 are in communication.

[0061] Preferably, the second cylindrical member 20 has an inner surface 20c facing the inner lumen 20e of the second cylindrical member 20 and an outer surface 20d facing the outside of the second cylindrical member 20.

[0062] The inner diameter of the second cylindrical member 20 may decrease towards the midpoint of the second cylindrical member 20 in the longitudinal direction x of the puncture needle 1. This makes it easier to narrow the path through which the liquid passes between the distal end 20a and the proximal end 20b of the second cylindrical member 20, thereby making it easier to reduce the amount of liquid used.

[0063] As shown in Figure 2, the distal end of the second cylindrical member 20 may have a portion where the inner diameter increases toward the distal end. The proximal end of the second cylindrical member 20 may also have a portion where the inner diameter increases toward the proximal end. This makes it easier to narrow the path through which the liquid passes between the distal end 20a and the proximal end 20b of the second cylindrical member 20, thereby making it easier to reduce the amount of liquid used.

[0064] The method of connecting the second cylindrical member 20 and the puncture needle 1 is not particularly limited. Examples include fixing by welding, welding, adhesive, crimping, etc. Among these, it is preferable that the second cylindrical member 20 and the puncture needle 1 are bonded together with an adhesive.

[0065] For example, polyurethane-based, epoxy-based, cyano-based, fluorine-based, and silicone-based adhesives can be used.

[0066] The second cylindrical member 20 may consist of only one cylindrical member, or it may consist of multiple cylindrical members.

[0067] The second cylindrical member 20 can be made of resin, metal, or the like. The second cylindrical member 20 may be made entirely of metal, or entirely of resin. The second cylindrical member 20 may be made partly of metal and the other part of resin.

[0068] Examples of metals that make up the second cylindrical member 20 include stainless steel such as SUS304 and SUS316, platinum, nickel, cobalt, chromium, titanium, tungsten, gold, Ni-Ti alloy, Co-Cr alloy, or combinations thereof.

[0069] Examples of resins constituting the second cylindrical member 20 include synthetic resins such as polyolefin resins (e.g., polyethylene and polypropylene), polyamide resins (e.g., nylon), polyester resins (e.g., PET), aromatic polyetherketone resins (e.g., PEEK), polyetherpolyamide resins, polyurethane resins, polyimide resins, and fluororesins (e.g., PTFE, PFA, ETFE), or combinations thereof.

[0070] The second cylindrical member 20 preferably includes a portion made of a resin-containing material. Only a portion of the second cylindrical member 20 may be made of resin, or the entire second cylindrical member 20 may be made of resin. The second cylindrical member 20 is preferably made of an elastically deformable material.

[0071] As shown in Figure 5, the lumen 20e of the second cylindrical member 20 may extend in a helical shape. Only a portion of the lumen 20e of the second cylindrical member 20 may extend in a helical shape, or the entire lumen 20e of the second cylindrical member 20 may extend in a helical shape. The helical extension of the lumen 20e of the second cylindrical member 20 allows the flow of liquid through the lumen 20e to be helical, making it less likely for cells to accumulate on the inner surface 20c of the second cylindrical member 20. As shown in Figure 5, the second cylindrical member 20 itself may extend in a straight line, while the lumen 20e of the second cylindrical member 20 may extend in a helical shape. Although not shown, the lumen 20e of the second cylindrical member 20 may extend in a helical shape by arranging the second cylindrical member 20 itself in a helical shape.

[0072] It is preferable that the thermal conductivity measured on the inner surface 20c of the second cylindrical member 20 is lower than the thermal conductivity measured on the inner surface 10c of the first cylindrical member 10. By making the thermal conductivity on the inner surface 20c of the second cylindrical member 20 relatively low, the temperature change of the liquid tends to be smaller, which helps to reduce the decrease in the effectiveness of the drug contained in the drug solution and the damage to the cells contained in the cell-containing solution. From a similar viewpoint, it is also preferable that the thermal conductivity measured on the inner surface 20c of the second cylindrical member 20 is lower than the thermal conductivity measured on the outer surface 10d of the first cylindrical member 10. However, it is also permissible that the thermal conductivity measured on the inner surface 20c of the second cylindrical member 20 is higher than the thermal conductivity measured on the inner surface 10c of the first cylindrical member 10 or the outer surface 10d of the first cylindrical member 10.

[0073] It is preferable that the second cylindrical member 20 has lower bending rigidity than the first cylindrical member 10. If the bending rigidity of the second cylindrical member 20, which is positioned in the lumen 10e of the first cylindrical member 10, is higher than that of the first cylindrical member 10, the second cylindrical member 20 may not be able to follow the deformation of the first cylindrical member 10, thus hindering the deformation of the first cylindrical member 10. By having a lower bending rigidity of the second cylindrical member 20, which is positioned in the lumen 10e of the first cylindrical member 10, the second cylindrical member 20 is able to follow the deformation of the first cylindrical member 10 more easily. This makes it easier to improve the operability of the puncture catheter 100. However, an embodiment in which the bending rigidity of the second cylindrical member 20 is higher than that of the first cylindrical member 10 is also acceptable.

[0074] As shown in Figure 2, it is preferable that the inner diameter of the second cylindrical member 20 at the first position 201 is larger than the inner diameter of the second cylindrical member 20 at the second position 202, which is located more proximal to the first position 201. This makes it easier to narrow the path through which the liquid passes at the second position 202, thereby making it easier to reduce the amount of liquid used.

[0075] As shown in Figure 2, it is preferable that the inner diameter of the second cylindrical member 20 at the second position 202 is smaller than the inner diameter of the second cylindrical member 20 at the third position 203, which is located more proximal to the second position 202. This makes it easier to connect the proximal end of the second cylindrical member 20 to the connecting member 40 described later, while also making it easier to narrow the path through which the liquid passes at the second position 202.

[0076] The first position 201 is preferably the distal end 20a of the second cylindrical member 20. The second position 202 is preferably the midpoint between the distal end 20a and the proximal end 20b of the second cylindrical member 20. The third position 203 is preferably the proximal end 10b of the second cylindrical member 20.

[0077] As shown in Figure 2, it is preferable that the second cylindrical member 20 has a tapered portion 22 whose outer diameter increases toward the distal end. It is even more preferable that the second cylindrical member 20 has a tapered portion 22 at its distal end, whose outer diameter increases toward the distal end. This makes it easier to narrow the path through which the fluid passes, even when using a puncture needle 1 with a relatively large diameter, and makes it easier to reduce the amount of fluid used.

[0078] The length of the first cylindrical member 10 in the longitudinal direction x of the puncture needle 1 and the length of the second cylindrical member 20 in the longitudinal direction x of the puncture needle 1 can be 1100 mm or more, 1330 mm or more, 1560 mm or more, etc. The length of the first cylindrical member 10 in the longitudinal direction x of the puncture needle 1 and the length of the second cylindrical member 20 in the longitudinal direction x of the puncture needle 1 can be 2300 mm or less, 2070 mm or less, 1840 mm or less, etc. The length of the first cylindrical member 10 in the longitudinal direction x of the puncture needle 1 refers to the longest length of the length of the first cylindrical member 10 in the longitudinal direction x of the puncture needle 1. The length of the second cylindrical member 20 in the longitudinal direction x of the puncture needle 1 refers to the longest length of the length of the second cylindrical member 20 in the longitudinal direction x of the puncture needle 1. Furthermore, when used as a puncture catheter for puncturing the myocardium, it is preferable that the length of the first cylindrical member 10 in the longitudinal direction x of the puncture needle 1 and the length of the second cylindrical member 20 in the longitudinal direction x of the puncture needle 1 are 1500 mm. The length of the first cylindrical member 10 in the longitudinal direction x of the puncture needle 1 and the length of the second cylindrical member 20 in the longitudinal direction x of the puncture needle 1 may be the same or different.

[0079] The length of the first tubular member 10 in the radial direction y of the puncture needle 1 can be 0.3 mm or more, 0.5 mm or more, 0.8 mm or more, etc. The length of the first tubular member 10 in the radial direction y of the puncture needle 1 can be 20.0 mm or less, 15.0 mm or less, 10.0 mm or less, etc. The length of the first tubular member 10 in the radial direction y of the puncture needle 1 refers to the longest length of the first tubular member 10 in the radial direction y of the puncture needle 1. When used as a puncture catheter for puncturing the myocardium, it is preferable that the length of the first tubular member 10 in the radial direction y of the puncture needle 1 be 0.9 mm.

[0080] The length of the second cylindrical member 20 in the radial direction y of the puncture needle 1 can be 0.1 mm or more, 0.2 mm or more, 0.3 mm or more, etc. The length of the second cylindrical member 20 in the radial direction y of the puncture needle 1 can be 15.0 mm or less, 10.0 mm or less, 5.0 mm or less, etc. The length of the second cylindrical member 20 in the radial direction y of the puncture needle 1 refers to the longest length of the second cylindrical member 20 in the radial direction y of the puncture needle 1. When used as a puncture catheter for puncturing the myocardium, it is preferable that the length of the second cylindrical member 20 in the radial direction y of the puncture needle 1 be 0.5 mm.

[0081] As shown in Figure 2, it is preferable that the second cylindrical member 20 has a tapered portion 23 whose outer diameter increases towards the proximal side. It is even more preferable that the second cylindrical member 20 has a tapered portion 23 at its proximal end, where the outer diameter increases towards the proximal side. This makes it easier to connect the proximal end of the second cylindrical member 20 to the connecting member 40, while also making it easier to narrow the path through which the liquid passes.

[0082] As shown in Figure 2, the second cylindrical member 20 may have multiple sections with different inner diameters in the longitudinal direction of the second cylindrical member 20. As shown in Figure 5, the inner diameter of the second cylindrical member 20 may be constant for a length from the distal end 20a to the proximal end 20b of the second cylindrical member 20.

[0083] As shown in Figures 2, 3, 5, and 6, it is preferable that the inner surface 10c of the first cylindrical member 10 and the outer surface 20d of the second cylindrical member 20 are separated. This allows the outer diameter of the first cylindrical member 10 to be made relatively large, which makes it easier to improve the operability of the puncture catheter 100. Also, it makes it easier to make the inner diameter of the second cylindrical member 20 relatively small, which makes it easier to reduce the amount of residual liquid and thus reduce the amount of liquid used.

[0084] As shown in Figures 2, 3, 5, and 6, it is preferable that a void exists between the inner surface 10c of the first cylindrical member 10 and the outer surface 20d of the second cylindrical member 20. More preferably, air is present in this void. This helps to reduce temperature changes in the liquid, thereby reducing the decrease in the effectiveness of the drugs contained in the drug solution and the damage to the cells contained in the cell-containing solution.

[0085] As shown in Figures 2 and 5, it is preferable that the first connection portion 31, which is the portion where the first cylindrical member 10 and the puncture needle 1 are connected, is located distal to the distal end of the second connection portion 32, which is the portion where the second cylindrical member 20 and the puncture needle 1 are connected. More specifically, it is preferable that the distal end of the first connection portion 31, which is the portion where the first cylindrical member 10 and the puncture needle 1 are connected, is located distal to the distal end of the second connection portion 32, which is the portion where the second cylindrical member 20 and the puncture needle 1 are connected. It is preferable that the first cylindrical member 10 and the puncture needle 1 are in contact at the first connection portion 31. It is preferable that the second cylindrical member 20 and the puncture needle 1 are in contact at the second connection portion 32.

[0086] The puncture catheter 100 may further have a connecting member 40 having a lumen 40e and connected to the proximal portions of the first tubular member 10 and the second tubular member 20. The lumen 40e of the connecting member 40 communicates with the lumen 20e of the second tubular member 20, and the tip of a syringe may be inserted into the lumen 40e of the connecting member 40. This facilitates the injection of the liquid in the syringe into the lumen 20e of the second tubular member 20. The liquid injected into the lumen 20e of the second tubular member 20 may be transported to the target tissue by passing through the lumen 1e and hole 5 of the puncture needle 1.

[0087] As shown in Figures 2 and 5, the second cylindrical member 20 may have a section with an inner diameter less than or equal to the inner diameter of the connecting member 40 at its distal end. As shown in Figure 5, the entire second cylindrical member 20 may have a section with an inner diameter less than or equal to the inner diameter of the connecting member 40 at its distal end. As shown in Figure 2, only a part of the second cylindrical member 20 may have a section with an inner diameter less than or equal to the inner diameter of the connecting member 40 at its distal end. The second cylindrical member 20 provided in the puncture catheter 100 has a section with an inner diameter less than or equal to the inner diameter of the connecting member 40 at its distal end, which makes it easier to narrow the path through which the liquid passes. This makes it easier to reduce the amount of liquid remaining in the lumen 20e of the second cylindrical member 20, and thus easier to reduce the amount of liquid used.

[0088] As shown in Figures 2 and 5, the proximal end of the third connection portion 33, where the first cylindrical member 10 and the connecting member 40 are connected, may be located more proximal to the proximal end of the fourth connection portion 34, where the second cylindrical member 20 and the connecting member 40 are connected. Although not shown, the proximal end of the third connection portion 33, where the first cylindrical member 10 and the connecting member 40 are connected, may be located more distal to the proximal end of the fourth connection portion 34, where the second cylindrical member 20 and the connecting member 40 are connected. It is preferable that the first cylindrical member 10 and the connecting member 40 are in contact at the third connection portion 33. It is preferable that the second cylindrical member 20 and the connecting member 40 are in contact at the fourth connection portion 34.

[0089] The constituent material of the connecting member 40 is not particularly limited, but for example, polyolefin resins such as polypropylene (PP) and polyethylene (PE), polyester resins such as polyethylene terephthalate (PET), synthetic resins such as polycarbonate resin, ABS resin, and polyurethane resin can be used. [Explanation of Symbols]

[0090] 1: Puncture needle 1a: Distal end 1b: Proximal end 1c: Inner surface 1d: Outer surface 1e: lumen 2: Cylindrical member 2a: Distal end 2b: Proximal end 2e: lumen 3: Helical member 4: Wire rod 5: Hole 10: First cylindrical member 10a: Distal end 10b: Proximal end 10c: Inner surface 10d: Outer surface 10e: lumen 11: Metal layer 11c: Inner surface 11d: Outer surface 11f: Groove 12: Outer resin layer 13: Inner resin layer 20: Second cylindrical member 20a: Distal end 20b: Proximal end 20c: Inner surface 20d: Outer surface 20e: lumen 201: First position 202: Second position 203: Third Position 21: Section 22: Tapered section 23: Tapered section 31: First connection section 32: Second connection section 33: Third connection section 34: Fourth connection section 40: Connecting member 40e: lumen 100: Puncture catheter

Claims

1. A medical puncture needle having a longitudinal direction and a lumen extending in the longitudinal direction, A first cylindrical member having a lumen extending in the longitudinal direction and connected to the puncture needle, A second cylindrical member is positioned within the lumen of the first cylindrical member, having a lumen extending in the longitudinal direction through which liquid passes, and is connected to the puncture needle. It has, The second cylindrical member is a puncture catheter having a section at the proximal end of the puncture needle having an inner diameter less than or equal to the outer diameter of the puncture needle.

2. The puncture catheter according to claim 1, wherein the thermal conductivity measured on the inner surface of the second cylindrical member is lower than the thermal conductivity measured on the inner surface of the first cylindrical member.

3. The puncture catheter according to claim 1 or 2, wherein the second tubular member has lower bending rigidity than the first tubular member.

4. The puncture catheter according to claim 1 or 2, wherein the inner diameter of the second cylindrical member at the first position is larger than the inner diameter of the second cylindrical member at the second position located proximal to the first position.

5. The puncture catheter according to claim 1 or 2, wherein the second cylindrical member has a tapered portion whose outer diameter increases toward the distal end.

6. The puncture catheter according to claim 1 or 2, wherein the inner surface of the first cylindrical member and the outer surface of the second cylindrical member are separated.

7. A puncture catheter according to claim 1 or 2, wherein a gap exists between the inner surface of the first cylindrical member and the outer surface of the second cylindrical member.

8. The puncture catheter according to claim 1 or 2, wherein the first connection portion, which is the portion where the first tubular member and the puncture needle are connected, is located distal to the distal end of the second connection portion, which is the portion where the second tubular member and the puncture needle are connected.

9. The puncture catheter according to claim 1 or 2, wherein the first cylindrical member includes a portion made of a material containing metal, and the second cylindrical member includes a portion made of a material containing resin.

10. The puncture catheter according to claim 1 or 2, wherein the first cylindrical member and the puncture needle are welded together, and the second cylindrical member and the puncture needle are bonded together with an adhesive.

11. The puncture catheter according to claim 1 or 2, wherein the inner diameter at the proximal end of the puncture needle is smaller than the inner diameter of the first cylindrical member at the midpoint of the first cylindrical member in the longitudinal direction.

12. The puncture catheter according to claim 1 or 2, wherein the lumen of the puncture needle and the lumen of the second cylindrical member are in communication, and the lumen of the puncture needle and the lumen of the first cylindrical member are not in communication.

13. The puncture catheter according to claim 1 or 2, wherein the lumen of the second cylindrical member extends in a helical shape.

14. The puncture catheter according to claim 1 or 2, wherein the first cylindrical member comprises a metal layer and an outer resin layer disposed on the outer surface of the metal layer.

15. The puncture catheter according to claim 1 or 2, wherein the liquid is a cell-containing solution.

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