Compositions, cosmetics

Abstract

The present invention relates to a composition that can form a bicelle structure with phospholipids as essential components using a simple manufacturing method, and that also exhibits excellent stability. [Solution] The composition of the present invention comprises the following components (A), (B), (C), (D), and (E), The mass ratio of component (B) to the sum of component (A) and component (B) [component (B) / (component (A) + component (B))] is 0.5 to 0.95. The mass ratio of component (C) to component (A) [component (C) / component (A)] is 2.5 or greater. Ingredient (A): Hydrogenated lecithin Ingredient (B): Lysolecithin Component (C): One or more polyhydric alcohols selected from the group consisting of 1,3-butylene glycol, dipropylene glycol, propylene glycol, and propanediol. Ingredient (D): Phosphate buffer Ingredient (E): Water

Description

Technical Field

[0001] The present invention relates to compositions and cosmetics.

Background Art

[0002] A bicelle structure is known as a disk-shaped lipid bilayer structure formed of phospholipids, and is a nanocarrier substance expected to have a drug permeation effect and an effect of improving the stratum corneum barrier function. In particular, among the disk-shaped structures of the bicelle structure, it is considered that phospholipids are oriented in the flat plate portion and components having a relatively bulky structure are oriented in the edge portion. For example, Patent Document 1 reports a bicelle structure suitable for use in cosmetics and external skin preparations, which is a combination of phospholipids and several surfactants as components to be incorporated into the edge portion.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, in Patent Document 1, in order to form a bicelle structure by a method usable for applications to cosmetics and drugs, it was necessary to add a relatively large amount of surfactant. On the other hand, since phospholipids, which are one of the essential components constituting the bicelle structure, are known as components that exhibit various physiological actions such as a skin care effect, it is expected that the physiological activity of the bicelle structure itself can be improved by increasing the proportion of phospholipids (phospholipids, lysophospholipids, etc.) in the bicelle structure. Therefore, the present inventors have been working on searching for a bicelle structure that can be formed even when only phospholipids are used as essential components.

[0005] Therefore, the object of the present invention is to provide a composition that can form a bicelle structure in which phospholipids are essential components and that also exhibits excellent stability. [Means for solving the problem]

[0006] As a result of diligent research to achieve the above objective, the present inventors have found that a composition comprising hydrogenated lecithin, lysolecithin, one or more polyhydric alcohols selected from the group consisting of 1,3-butylene glycol, dipropylene glycol, propylene glycol, and propanediol, a phosphate buffer, and water, wherein the hydrogenated lecithin and lysolecithin satisfy a specific mass ratio, and the hydrogenated lecithin and the above polyhydric alcohols satisfy a specific mass ratio, can form a bicelle structure in which phospholipids are essential components, and also exhibits excellent stability. The present invention was completed based on these findings.

[0007] In other words, the present invention comprises the following components (A), (B), (C), (D), and (E): The mass ratio of component (B) to the sum of component (A) and component (B) [component (B) / (component (A) + component (B))] is 0.5 to 0.95. The present invention provides a composition in which the mass ratio of component (C) to component (A) [component (C) / component (A)] is 2.5 or greater. Ingredient (A): Hydrogenated lecithin Ingredient (B): Lysolecithin Component (C): One or more polyhydric alcohols selected from the group consisting of 1,3-butylene glycol, dipropylene glycol, propylene glycol, and propanediol. Ingredient (D): Phosphate buffer Ingredient (E): Water

[0008] The above composition preferably contains 0.01 to 3.0% by mass of component (A).

[0009] The above composition preferably contains disc-shaped micelles.

[0010] The present invention also provides a cosmetic containing the above composition.

Advantages of the Invention

[0011] The composition of the present invention can form a bicelle structure having phospholipids as essential components, and a composition excellent in stability can be produced.

Brief Description of the Drawings

[0012] [Figure 1] It is a TEM image of the composition of Example 6. [Figure 2] It is a TEM image of the composition of Example 7. [Figure 3] It is a TEM image of the composition of Example 8. [Figure 4] It is a TEM image of the composition of Example 2. [Figure 5] It is a TEM image of the composition of Example 5. [Figure 6] It is a TEM image of the composition of Example 9. [Figure 7] It is a TEM image of the composition of Example 11. [Figure 8] It is a TEM image of the composition of Example 13. [Figure 9] It is a TEM image of the composition of Example 15. [Figure 10] It is a TEM image of the composition of Example 21. [Figure 11] It is a TEM image of the composition of Example 22. [Figure 12] It is a TEM image of the composition of Example 25. [Figure 13] It is a TEM image of the composition of Example 26.

Modes for Carrying Out the Invention

[0013] Unless otherwise specified in this specification, "X~Y" representing a numerical range is intended to mean "X or more and Y or less". Further, unless otherwise specified in this specification, the mass% representing the content ratio of a component is a value based on the assumption that the total mass of the composition is 100 mass%.

[0014] [Composition] The composition of the present invention contains at least hydrogenated lecithin, lysolecithin, one or more polyhydric alcohols selected from the group consisting of 1,3-butylene glycol, dipropylene glycol, propylene glycol, and propanediol, a phosphate buffer, and water. In this specification, the above composition may be referred to as "the composition of the present invention".

[0015] In this specification, the above "hydrogenated lecithin" may be referred to as "component (A)", the above "lysolecithin" may be referred to as "component (B)", the above "one or more polyhydric alcohols selected from the group consisting of 1,3-butylene glycol, dipropylene glycol, propylene glycol, and propanediol" may be referred to as "component (C)", the above "phosphate buffer" may be referred to as "component (D)", and the above "water" may be referred to as "component (E)".

[0016] That is, the composition of the present invention contains at least component (A), component (B), component (C), component (D), and component (E). Further, the composition of the present invention may contain other components other than the above components (A) to (E).

[0017] The composition of the present invention preferably contains disk-shaped micelles. The above disk-shaped micelles have a disk-shaped lipid bilayer structure (so-called bicelle structure) containing at least component (A) and component (B) as constituent components. The above disk-shaped micelles may be present as a single structure dispersed, or a structure (spherical or columnar structure) formed by stacking a plurality of disk-shaped micelles in a direction perpendicular to the disk plane may be formed.

[0018] The average particle size (average particle diameter) of the above-mentioned disc-shaped micelles is preferably 5 nm or larger, more preferably 8 nm or larger, even more preferably 9.5 nm or larger, and most preferably 10 nm or larger. An average particle size of 5 nm or larger makes it easier to secure space for incorporating other components within the disc-shaped micelles. Furthermore, the average particle size is preferably 100 nm or smaller, more preferably 75 nm or smaller, and even more preferably 50 nm or smaller. An average particle size of 100 nm or smaller allows for excellent transparency. The average particle size can be measured using dynamic light scattering (dynamic light scattering photometer) or transmission electron microscope (TEM).

[0019] The composition of the present invention preferably contains a structure with an average particle size of 5 to 100 nm as measured by dynamic light scattering. The average particle size of the above structure is more preferably 8 to 75 nm, even more preferably 9.5 to 50 nm, and most preferably 10 to 50 nm.

[0020] The composition of the present invention, by including the above-mentioned disc-shaped micelles, can be used in particular as a carrier to hold active ingredients according to its application. In addition, since the above-mentioned disc-shaped micelles are mainly composed of component (A) and component (B), the disc-shaped micelles themselves can exert skincare effects, etc. For this reason, the above-mentioned disc-shaped micelles can be used even when they are not holding other active ingredients as a carrier.

[0021] The pH of the composition of the present invention is preferably 5.0 to 8.0, and more preferably 6.0 to 7.5. Having the pH of the composition of the present invention within this range further stabilizes the structure of the disc-shaped micelles and improves the stability of the composition.

[0022] <Ingredient (A)> Component (A) is hydrogenated lecithin. Component (A) is, for example, a component that forms the disc-shaped micelles described above, and is presumed to mainly constitute the planar portion thereof. Component (A) may be used alone or two or more types.

[0023] Component (A) is a hydrogenated phospholipid. Specifically, it is a complex lipid containing phosphate residues, and examples include naturally derived phospholipids, natural phospholipids, synthetic phospholipids, and hydrogenated phospholipids in which the unsaturated carbon chain in the phospholipid is saturated with hydrogen. Examples of the above phospholipids include naturally derived phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, lysophosphatidylcholine, and sphingomyelin; natural phospholipids such as egg yolk lecithin and soy lecithin; and synthetic phospholipids such as dilauroyl phosphatidylcholine, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, distearoyl phosphatidylcholine, dioleoyl phosphatidylcholine, and palmitoyl oleoyl phosphatidylcholine. From the viewpoint of facilitating the formation of disc-shaped micelles, it is preferable that component (A) contains hydrogenated phosphatidylcholine. For component (A), hydrogenated soybean phospholipids are preferred, for example.

[0024] The above-mentioned phospholipid preferably contains 50% by mass or more of phosphatidylcholine, and more preferably 70% by mass or more.

[0025] The content of component (A) is preferably 0.01 to 3.0% by mass, and more preferably 0.05 to 2.0% by mass, based on 100% by mass of the composition of the present invention. A content of 0.01% by mass or more of component (A) facilitates the formation of disc-shaped micelles. A content of 3.0% by mass or less of component (A) allows it to dissolve in the composition, making it easier for the composition to exhibit stability.

[0026] <Ingredient (B)> Component (B) is lysolecithin. Component (B) is obtained by treating a complex lipid containing phosphate residues with phospholipase to remove the acyl group and improve its hydrophilicity. Component (B) is not hydrogenated lysolecithin. Furthermore, component (B) is presumed to be, for example, the main component that forms the above-mentioned disc-shaped micelles, and mainly constitutes their edges. Component (B) may be used alone or in combination of two or more types.

[0027] Component (B) is preferably a phospholipid treated with phospholipase, as exemplified in component (A), and specifically, lysophosphatidylcholine is a good example. Furthermore, from the viewpoint of stabilizing the structure of the disc-shaped micelles, component (B) is not hydrogenated and contains an unsaturated carbon chain.

[0028] In the composition of the present invention, the mass ratio of component (B) to the total of component (A) and component (B) [component (B) / (component (A) + component (B))] is 0.5 to 0.95, preferably 0.55 to 0.90. A mass ratio of 0.5 or higher ensures a sufficient content of component (B) relative to component (A), resulting in excellent stability as a composition. Furthermore, a mass ratio of 0.95 or lower facilitates the production of disc-shaped micelles.

[0029] <Component (C)> Component (C) is one or more polyhydric alcohols selected from the group consisting of 1,3-butylene glycol, dipropylene glycol, propylene glycol (1,2-propanediol), and propanediol (1,3-propanediol). Component (C) is added as a solvent in the composition of the present invention, and is particularly added to stably dissolve component (A) in the composition of the present invention and to facilitate the production of disc-shaped micelles. Component (C) may be used alone or two or more.

[0030] Component (C) is preferably 1,3-butylene glycol (1,3-BG) due to its ease of dissolving of component (A).

[0031] The content of component (C) is preferably 0.25 to 20.0% by mass, and more preferably 0.5 to 15.0% by mass, based on 100% by mass of the composition of the present invention. A content of 0.25% by mass or more of component (C) facilitates the dissolution of component (A) and facilitates the formation of disc-shaped micelles. A content of 20.0% by mass or less of component (C) further improves stability.

[0032] In the composition of the present invention, the mass ratio of component (C) to component (A) [component (C) / component (A)] is 2.5 or higher, preferably 3.5 or higher. A mass ratio of 2.5 or higher for component (C) to component (A) allows for the dissolution of component (A) and enables the composition to exhibit stability. Alternatively, the mass ratio of component (C) to component (A) may be 300 or lower.

[0033] <Ingredient (D)> Component (D) is a phosphate-based buffering agent. The composition of the present invention can be made more stable by including component (D), and in particular, when disc-shaped micelles are formed, the structure of the disc-shaped micelles can be stabilized. Furthermore, component (D) may be used alone or two or more types may be used.

[0034] Component (D) specifically includes alkali metal phosphate buffers and alkaline earth metal phosphate buffers. Component (D) is preferably an alkali metal phosphate buffer, and examples of such buffers include sodium phosphate buffers such as sodium dihydrogen phosphate (monosodium dihydrogen phosphate) and sodium monohydrogen phosphate (disodium monohydrogen phosphate); and potassium phosphate buffers such as monopotassium dihydrogen phosphate and dipotassium monohydrogen phosphate. In particular, component (D) preferably contains sodium monohydrogen phosphate and / or sodium dihydrogen phosphate, and more preferably contains both sodium monohydrogen phosphate and sodium dihydrogen phosphate.

[0035] Furthermore, component (D) is preferably added so that the composition of the present invention is adjusted to the above pH range, and its content is preferably 0.001 to 1.0% by mass, and more preferably 0.002 to 0.5% by mass, based on 100% by mass of the composition of the present invention. <Ingredient (E)> Component (E) is water. Component (E) is an ingredient added to the composition of the present invention as a solvent. Examples of component (E) include purified water, tap water, hot spring water, deep sea water, etc. Furthermore, only one type of component (E) may be used, or two or more types may be used.

[0036] The content of component (E) is preferably 20.0 to 99.9% by mass, more preferably 40.0 to 99.0% by mass, and even more preferably 70.0 to 95.0% by mass, based on 100% by mass of the composition of the present invention.

[0037] The composition of the present invention may contain polyhydric alcohols other than component (C) (sometimes referred to as "other polyhydric alcohols"). These other polyhydric alcohols are components added as solvents to the composition of the present invention. Only one type of these other polyhydric alcohols may be used, or two or more types may be used.

[0038] Other polyhydric alcohols include, for example, glycols other than component (C), such as ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, isoprene glycol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol; glycerin compounds such as glycerin, diglycerin, and polyglycerin; and sugar alcohols such as xylitol, trehalose, maltitol, mannitol, sorbitol, erythritol, arabitol, ribitol, galactitol, glucitol, erythritol, glycosyltrehalose, and hydrolyzed hydrogenated starch.

[0039] The content of the above-mentioned other polyhydric alcohols may be 0.01 to 40.0% by mass or 0.05 to 30.0% by mass, based on 100% by mass of the composition of the present invention.

[0040] <Other ingredients> The composition of the present invention may further contain components (A) to (E) and other components other than the above-mentioned polyhydric alcohols. Examples of the above-mentioned other components include surfactants, antibacterial agents, ultraviolet absorbers, powders, antioxidants, preservatives, fragrances, colorants, cooling agents, thickeners, vitamins, neutralizing agents, amino acids, whitening agents, anti-inflammatory agents, deodorants, and additives such as plant and animal extracts. Only one of the above-mentioned other components may be used, or two or more may be used.

[0041] The composition of the present invention may contain a chelating agent as one of the other components mentioned above, but in order to further improve stability, the content of the chelating agent is preferably 1.0% by mass or less, more preferably 0.5% by mass or less, even more preferably 0.1% by mass or less, and particularly preferably 0% by mass, based on 100% by mass of the composition of the present invention. In other words, it is preferable that the composition of the present invention does not contain a chelating agent.

[0042] The composition of the present invention may contain electrolytes other than component (D) as other components as described above, but in order to further improve stability, the content of such electrolytes is preferably 1.0% by mass or less, more preferably 0.1% by mass or less, even more preferably 0.01% by mass or less, and particularly preferably 0% by mass, based on 100% by mass of the composition of the present invention. In other words, it is preferable that the composition of the present invention does not contain electrolytes other than component (D).

[0043] The composition of the present invention may contain ethanol as one of the other components mentioned above, but in order to further improve the stability of the composition, its content is preferably 10.0% by mass or less, more preferably 3.0% by mass or less, even more preferably 1.0% by mass or less, and particularly preferably 0% by mass, based on 100% by mass of the composition of the present invention.

[0044] In this invention, by using hydrogenated lecithin [component (A)] and lysolecithin [component (B)] in specific proportions, and further combining them with specific polyhydric alcohols [component (C)], phosphate buffers [component (D)], and water [component (E)] in specific proportions, it is possible to form phospholipid structures, particularly disc-shaped micelles (bicelles), by a relatively simple manufacturing method, without necessarily using surfactants other than phospholipids, which were conventionally essential components. In other words, it becomes possible to form structures (particularly disc-shaped micelles) that consist only of components (A) and (B) that are expected to have physiological activity, or structures (particularly disc-shaped micelles) that mainly consist of these components. As a result, it is possible to eliminate or reduce other surfactants used in forming disc-shaped micelles, and improvements in physiological activity and reduction of skin irritation can be expected.

[0045] As described above, the composition of the present invention does not necessarily require the use of surfactants other than components (A) and (B) as essential components. However, surfactants other than components (A) and (B) may be used as optional components for purposes such as improving the stability of disc-shaped micelles. In this specification, surfactants other than components (A) and (B) may be referred to as "surfactant (X)". Furthermore, if the composition of the present invention contains surfactant (X), only one type of surfactant (X) may be used, or two or more types may be used.

[0046] Examples of surfactants (X) include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. Examples of nonionic surfactants include polyglycerin fatty acid esters such as polyglyceryl-10 myristate, polyglyceryl-10 laurate, and polyglyceryl-6 caprylate; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene coconut oil fatty acid sorbitan (20 E.O.); polyoxyethylene hydrogenated castor oil such as PEG-60 hydrogenated castor oil; and polyoxyalkylene sterols such as PEG-20 phytosterol and PEG-25 phytostanol. Examples of anionic surfactants include N-acyl amino acid salts such as sodium N-coconut oil fatty acid acyl-L-alanine, sodium N-coconut oil fatty acid acyl-L-glutamate, sodium N-coconut oil fatty acid acylglycine, and sodium N-lauroyl L-aspartate. Examples of the cationic surfactants mentioned above include N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylate and benzalkonium chloride.

[0047] The content of surfactant (X) may be 2.5% by mass or less, 1.0% by mass or less, or 0% by mass, based on 100% by mass of the composition of the present invention. In other words, the composition of the present invention may not contain surfactant (X).

[0048] As described above, the composition of the present invention can form disc-shaped micelles by a relatively simple manufacturing method. Specifically, conventional methods for forming bicelles without using surfactants other than phospholipids include the Bangham method, a method using a microfluidic device, and a method using an ultrasonic device. However, the present invention makes it possible to form disc-shaped micelles without such complicated manufacturing methods. A manufacturing method for the composition of the present invention includes, for example, a manufacturing method in which the above components (A) to (E) and other components as needed are mixed. In the above manufacturing method, some or all of the components may be mixed under heating conditions and then cooled after mixing. The mixing means is not particularly limited, and known and conventional stirring means such as a magnetic stirrer or manual stirring may be used.

[0049] More specifically, a method for producing the composition of the present invention includes the following: Homogenizing components (A), (B), and (C) under a temperature of 70°C to 90°C, then adding component (E), which has been heated to 70°C to 90°C, and stirring to homogenize. After that, the mixture is cooled to around room temperature of 20 to 30°C, component (D) is added, and then stirring to homogenize. The above cooling can be performed, for example, by stirring and cooling using a cold water bath at a water temperature of about 0 to 15°C, or by stirring and cooling in a room temperature environment. In the method for producing the composition of the present invention, it is not necessary to include steps such as dissolving each component in an organic solvent and forming a thin film by removing the organic solvent; ultrasonic treatment; or treatment using a microfluidic device during the manufacturing process. This makes it suitable for the production of cosmetics and topical skin preparations, as well as for industrial production.

[0050] The composition of the present invention prepared by the method described above contains component (A) and component (B), and these components exhibit skincare effects and nutritional effects, making it suitable for use in cosmetics, pharmaceuticals, foods, and the like.

[0051] [Cosmetics] One embodiment of the present invention is a cosmetic composition containing the composition of the present invention. In this specification, the above cosmetic composition may be referred to as "the cosmetic composition of the present invention." The cosmetic composition of the present invention can be manufactured by mixing the composition of the present invention with other components used in the production of the cosmetic composition. That is, the composition of the present invention can be used as a raw material (so-called intermediate raw material) for the manufacture of the cosmetic composition. By using the composition of the present invention, disc-shaped micelles formed from phospholipids can be incorporated into the cosmetic composition, and these disc-shaped micelles can be used as carriers for active ingredients or to exert skincare effects. Furthermore, the composition of the present invention can also be used as a cosmetic composition itself.

[0052] In the present invention, a cosmetic composition containing the composition of the present invention is obtained. The content ratio of the composition of the present invention to 100% by mass of the cosmetic composition of the present invention can preferably be 0.1 to 100% by mass, and more preferably 0.5 to 10.0% by mass.

[0053] Furthermore, the cosmetic composition of the present invention may further contain the other components listed above. That is, the other components may be added to the composition of the present invention, or they may be added to the cosmetic composition of the present invention (they may be added separately from the composition of the present invention).

[0054] Examples of the cosmetic formulations of the present invention include various formulations such as lotion, cream, gel, emulsion, aerosol spray, natural spray, stick, powder, roll-on, and sheet (paper).

[0055] Examples of cosmetic compositions of the present invention include hair cosmetics, skin cosmetics, and the like. Examples of skin cosmetics include skincare cosmetics such as moisturizing cosmetics, whitening cosmetics, acne care cosmetics, and anti-aging cosmetics (for example, those aimed at wrinkle suppression, sagging suppression, etc.); scalp care cosmetics (for example, those aimed at moisturizing, sebum suppression, etc.); deodorant cosmetics; sunscreen cosmetics; shaving cosmetics; body cleansers (for example, body shampoos, bar soaps, etc.); and scalp cleansers. Furthermore, the cosmetic compositions of the present invention may be, for example, cosmetics, quasi-drugs, pharmaceuticals, or general merchandise.

[0056] The areas to which the cosmetic composition of the present invention is applied are not particularly limited. In the case of the hair cosmetic composition, examples include hair, beard, etc. In the case of the skin cosmetic composition, examples include the face (e.g., forehead, around the eyes, corners of the eyes, cheeks, around the mouth, etc.), arms, elbows, back of the hands, fingertips, feet, knees, heels, neck, armpits, back, scalp, etc. [Examples]

[0057] The present invention will be described in more detail below based on examples, but the present invention is not limited to these examples. The amounts listed in the table are the amounts of each component (i.e., the amount of active ingredients in each raw material; so-called pure content), and are expressed in "mass%" unless otherwise specified.

[0058] Examples 1-27, Comparative Examples 1-8 Using the components shown in Tables 1 and 2, each composition for the Examples and Comparative Examples was prepared and subjected to the evaluation tests described below. The evaluation results are shown in both Tables 1 and 2.

[0059] The above preparation method is as follows: Components (A), (B), and (C) are homogenized under temperature conditions of 70°C to 90°C. Then, component (E), which has been heated under the same temperature conditions, is added and uniformly stirred. After that, the mixture is cooled and stirred using a cold water bath (water temperature 0 to 15°C) until it reaches 25°C. After cooling, component (D) is added and uniformly stirred to prepare the composition. For the composition of Example 14, the composition of Example 6, which has been prepared once, is diluted 10 times by adding purified water and used.

[0060] The details of the following components, listed in Tables 1 and 2, are shown below. <Ingredient (A)> Hydrogenated lecithin: Product name "LIPOID P100-3", manufactured by Lipoid GmbH. <Ingredient (B)> Lysolecithin: Product name "LIPOID P LPC80", manufactured by Lipoid GmbH. <Equivalent components other than component (B)> Hydrogenated lysolecithin: Product name "LP70H", manufactured by Nippon Seika Co., Ltd.

[0061] (evaluation) The compositions obtained in the examples and comparative examples were evaluated as follows. The evaluation results are shown in Tables 1 and 2. In addition, the pH of the compositions obtained in the examples and comparative examples was measured using a pH meter and is shown in Tables 1 and 2.

[0062] (1) Exterior The compositions of the examples and comparative examples were filled into 30 mL transparent screw-top cans, visually observed, and evaluated according to the following criteria. <Evaluation Criteria> ◎(Excellent): It is colorless and transparent. ○ (Good): Not cloudy, but slightly bluish-white in appearance. × (Poor): The surface is cloudy or precipitates are visible.

[0063] (2) Stability The compositions of the examples and comparative examples were stored at 25°C for 4 weeks, and the compositions after storage were evaluated according to the following criteria. <Evaluation Criteria> ○ (Good): No clouding or obvious precipitate formation; maintains initial properties. × (Poor): Whitening or obvious precipitate formation is observed.

[0064] (3) Average particle size The compositions of the examples were measured using a dynamic light scattering analyzer (device name "ELSZ-1000", manufactured by Otsuka Electronics Co., Ltd.) by dynamic light scattering, and the average particle size was calculated by cumulant analysis. The comparative compositions were not evaluated due to poor appearance and stability.

[0065] [Table 1]

[0066] [Table 2]

[0067] As can be seen from the results above, all of the compositions in the examples had excellent appearance and stability, and contained structures on the order of nanometers in size. On the other hand, all of the compositions in the comparative examples had poor appearance and stability. Furthermore, the compositions of Examples 2, 4-9, 11, 13-15, and 20-27 were observed using a transmission electron microscope (TEM). As a result, the structure of disc-shaped micelles (bicelles) was confirmed in Examples 2, 4-9, 11, 13-15, and 20-27. The figures show TEM images of Example 6 (Figure 1), Example 7 (Figure 2), Example 8 (Figure 3), Example 2 (Figure 4), Example 5 (Figure 5), Example 9 (Figure 6), Example 11 (Figure 7), Example 13 (Figure 8), Example 15 (Figure 9), Example 21 (Figure 10), Example 22 (Figure 11), Example 25 (Figure 12), and Example 26 (Figure 13). From these results, it was inferred that the above-mentioned structures in the compositions of the examples are disc-shaped micelles, and that bicelle structures are formed in the compositions of the examples.

[0068] The following are examples of cosmetic formulations (lotions) using the composition of the present invention (units are in mass%). [Table 3]

[0069] The following are examples of cosmetic formulations (creams) using the composition of the present invention (units are in mass%). [Table 4]

[0070] Variations of the present invention are described below. [Note 1] It contains the following ingredients (A), (B), (C), (D), and (E): The mass ratio of component (B) to the sum of component (A) and component (B) [component (B) / (component (A) + component (B))] is 0.5 to 0.95. A composition in which the mass ratio of component (C) to component (A) [component (C) / component (A)] is 2.5 or greater. Ingredient (A): Hydrogenated lecithin Ingredient (B): Lysolecithin Component (C): One or more polyhydric alcohols selected from the group consisting of 1,3-butylene glycol, dipropylene glycol, propylene glycol, and propanediol. Ingredient (D): Phosphate buffer Ingredient (E): Water [Note 2] The composition according to Appendix 1, wherein the content of component (A) is 0.01 to 3.0% by mass. [Note 3] The composition according to Appendix 1 or 2, comprising disc-shaped micelles. [Note 4] A cosmetic product containing the composition described in any one of the appendices 1 to 3.

Claims

1. It contains the following components (A), (B), (C), (D), and (E): The mass ratio of component (B) to the sum of component (A) and component (B) [component (B) / (component (A) + component (B))] is between 0.5 and 0.

95. A composition in which the mass ratio of component (C) to component (A) [component (C) / component (A)] is 2.5 or more. Ingredient (A): Hydrogenated lecithin Ingredient (B): Lysolecithin Component (C): One or more polyhydric alcohols selected from the group consisting of 1,3-butylene glycol, dipropylene glycol, propylene glycol, and propanediol. Ingredient (D): Phosphate-based buffering agent Ingredient (E): Water

2. The composition according to claim 1, wherein the content of component (A) is 0.01 to 3.0% by mass.

3. The composition according to claim 1 or 2, comprising disc-shaped micelles.

4. A cosmetic composition comprising the composition described in claim 1 or 2.

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