Wearable pet device involving passive diffusion of informational chemical composition

Abstract

This invention provides a portable pet device that can passively diffuse informational chemical composition. [Solution] The sedation device enables animals to cope well with stressful situations (such as separation, withdrawal, transport, noise, and fear of fireworks) and to adapt well to new situations.

Description

Technical Field

[0001] The present invention relates to a wearable pet device capable of passively diffusing an infochemical composition.

[0002] In particular, the present invention relates to a device capable of diffusing an infochemical composition for a longer time than devices known in the prior art.

Background Art

[0003] Devices capable of passively diffusing an infochemical composition are known in the prior art. An infochemical composition is a compound or mixture of compounds that animals naturally secrete to communicate within the same species. For example, during lactation, a female dog secretes pheromones to comfort her puppies when they are near. Similarly, cats secrete facial pheromones on their faces and deposit facial pheromones at known locations to mark familiar territories.

[0004] Numerous studies have been conducted to identify and synthetically replicate these mixtures of compounds.

[0005] Such mixtures of compounds are presented, for example, to help dogs cope well with stressful situations (such as separation situations, weaning, transportation, fear of noise and fireworks) and adapt well to new situations.

[0006] [[ID=​​​​Prior art collars, particularly those under the ADAPTIL® brand, contain an informational chemical composition whose active principle or informational chemical active ingredient is a synthetic analogue of the pheromone secreted by female dogs to soothe puppies upon contact. This composition consists of a polymer called ethylene vinyl acetate or EVA and a mixture of fatty acid methyl esters. The informational chemical composition impregnated in the polymer passively diffuses into the air and is perceived by the dog's vomeronasal organ.

[0008] The diffusion rate (or release rate) of this collar is, according to the manufacturer, the rate at which the collar can be used for four weeks. The applicant was able to demonstrate that after four weeks, only a small portion of the information chemical composition had actually diffused from the device. Thus, after four weeks, up to 14% of the information chemical composition initially present in the collar had diffused.

[0009] These results clearly demonstrate that impregnation of ethylene vinyl acetate with the information chemical composition does not allow for the complete release of the information chemical composition, and after 4 weeks, the pheromone release kinetics become very low, rendering the device ineffective. [Overview of the project] [Problems that the invention aims to solve]

[0010] Therefore, an object of the present invention is to improve prior art devices, particularly pet collars containing information chemical compositions.

[0011] A first object of the present invention is to enable the diffusion of information chemical composition over a longer period of time, particularly over a period exceeding one month, compared to prior art devices.

[0012] A second object of the present invention is to enable the diffusion of a higher relative amount of information chemical composition to the outside of the device compared to prior art devices, relative to the total amount inside the device.

[0013] A third object of the present invention is to enable controlled diffusion, i.e., the continuous release of equivalent average amounts of the information chemical composition over at least two equal time intervals for each time period, compared to prior art devices.

[0014] A fourth object of the present invention is to provide a device that preferably satisfies the first and second objects and that retains sufficient flexibility to deform into any kind of object that can be used for animals, especially pets, particularly collars.

[0015] A fifth object of the present invention is to obtain a device that improves compliance with regulations regarding handling by pet owners, in particular by extending the operating time of the device and increasing the time between two applications of the device in the animal or in the environment surrounding the animal.

[0016] Unless otherwise specified, all percentages are given as the weight of the component relative to the total weight of the component (m / m).

[0017] The first object of the present invention is a device for continuously releasing information chemical compositions for pets to animals or to the environment surrounding animals, • Polymer matrix, ·Semiochemical composition, • A control factor that controls the diffusion of information chemical composition outside the device. • Depending on the case, antioxidants, • Depending on the case, an anti-UV agent may be used. • Flow agent may be used depending on the circumstances. The above devices include: [Means for solving the problem]

[0018] For this first objective, the present invention relates to a device for continuously releasing an information chemical composition for pets to an animal or to the environment surrounding the animal, • Polymer matrix, • Information chemical composition containing a mixture of volatile fatty acid derivatives, · A control factor selected from clay, diatomaceous earth, and zeolite for controlling the diffusion of the information chemical substance composition outside the device Regarding the above device containing the same.

Brief Description of the Drawings

[0019] [Figure 1] It is a diagram of a volatile fatty acid ester derivative. [Figure 2] It is a diagram of the time-dependent release of fatty acid methyl ester (Example 2A).

Mode for Carrying Out the Invention

[0020] The device according to the present invention is particularly a solid molded body that can be worn by an animal or installed in the immediate environment of an animal, for example, a collar, harness, collar pendant (medallion), ear tag, collar that can be attached to a limb or part of the body, an adhesive strip, and a film. Medallions and collars, especially collars, are preferred.

[0021] The immediate environment of an animal is defined as an area where an animal is likely to grow, such as the owner's home, doghouse, vehicle, transport cage, etc.

[0022] The molded body according to the present invention can also take the form of a ball that can be placed in a container by the user.

[0023] The device can also take the form of an object in the animal's environment, such as a bowl, floor mat, blanket, clothing, training mat, etc.

[0024] The size and shape of any device are adapted to the animal it is intended for. The device is attached, if necessary, by means of attachment known to those skilled in the art. For example, in the case of a system for attaching a collar consisting of an extruded strip, the fasteners may be molded plastic with rivets, secured with metal rivets, secured with metal clips, or a metal loop system having loops held in a folded strap by multiple rivets.

[0025] In the case of collars, it is also possible to provide collars of a standard length that will be cut by the pet owner to best fit the neck size of the animal, such as a puppy, small dog, medium dog, or large dog.

[0026] In one embodiment, the device according to the present invention is a collar of a predetermined length, to which a loop is attached that allows the excess length of the collar to be held in place by the portion of the collar that comes into contact with the animal's neck. The loop ensures that the entire length of the collar containing the information chemical composition is held in place, so that this excess length does not cause discomfort to the animal or its owner.

[0027] The device may have a smooth surface or a relief that increases the amount of information chemical active components released over a predetermined time.

[0028] Therefore, in the context of the present invention, the device is a composite comprising a polymer matrix as a continuous phase in which control factors that control the diffusion of the information chemical composition outside the device are dispersed. The terms “composite” and “polymer matrix” are understood in the sense of the present invention as being common to those skilled in the art (as defined, for example, in “Compendium-of-Polymer-Terminology-and-Nomenclature-IUPAC-Recommendations-2008”). The term “polymer matrix” refers to a matrix comprising polymers having a continuous non-foaming or honeycomb structure, and therefore excludes polymer foams and polymer materials having a honeycomb or cellular structure.

[0029] The polymer matrix must possess sufficient strength and flexibility to prevent the device from breaking or becoming brittle during manufacturing and use. The polymer matrix must also have sufficient durability to withstand normal wear and tear when the device is attached to or applied to an animal. Furthermore, the polymer matrix must allow for sufficient transfer of the information chemical composition to the device surface, i.e., passive diffusion, and release of the composition to the animal or its environment, particularly to the animal's olfactory organs.

[0030] Thermoplastic polymers, elastomers, and thermoplastic polyvinyl resins are advantageously used. Thermoplastic and flexible polyolefins and elastomers are suitable for use as carrier materials or base materials for molded articles. These include polyvinyl resins, EPDM (ethylene / propylene dienotherpolymer), polyethylene (e.g., HDPE or LLDPE), and polypropylene, which are well compatible with the active compounds mentioned above.

[0031] Polyvinyl resins include polyhalogenated vinyls, such as polyvinyl chloride, polyvinyl chloride-vinyl acetate, and polyvinyl fluoride; polyvinylbenzenes, such as polystyrene and polyvinyltoluene; and vinyl acetate copolymers, such as ethylene-vinyl acetate thermoplastic copolymers or EVA.

[0032] Other plastic materials suitable for use as the matrix of the device according to the present invention are thermoplastic elastomers. For example, thermoplastic polyolefins (TPO) are available.

[0033] Advantageously, the above-mentioned polyvinyl resin is used. Preferably, ethylene-vinyl acetate thermoplastic copolymer (EVA) is used. The properties of these copolymers, particularly flexibility and strength, vary depending on the vinyl acetate content (also called grade), preferably 5-20%, more preferably 5-16%, and more preferably about 9% vinyl acetate content of ethylene-vinyl acetate thermoplastic copolymer. These grades of EVA are particularly useful in the manufacture of animal collars.

[0034] The information chemical composition used is preferably a sedative information chemical composition comprising a mixture of volatile fatty acid derivatives.

[0035] For the purposes of the present invention, the sedative information chemical composition modifies a mixture of chemicals having interbiotic signal values, which are of natural origin (e.g., isolated from living organisms) or of synthetic origin (e.g., obtained by mixing volatile derivatives of fatty acids that can produce relaxing or sedative effects in animals).

[0036] For the purposes of this invention, "volatile fatty acid derivative" means any fatty acid derivative that can be diffused into an animal or into the animal's environment without applying an external electrical heat source to the device.

[0037] For the purposes of the present invention, "fatty acid" means a saturated or unsaturated linear or branched hydrocarbon monocarboxylic acid or dicarboxylic acid containing 4 to 22 carbon atoms. Advantageously, the fatty acid is selected from the group consisting of oleic acid, palmitic acid, azelaic acid, pimelic acid, capric acid, lauric acid, myristic acid, palmitoleic acid, linoleic acid, stearic acid, arachidonic acid, n-butyric acid, isobutyric acid, α-methylbutyric acid, caproic acid, pivalic acid, γ-linoleic acid, eicosapentanoic acid, pentadecanoic acid, tridecanoic acid, or docosahexanoic acid.

[0038] Volatile fatty acid derivatives include fatty acid esters, such as esters formed from a fatty acid and a C1-C6 alcohol. Advantageously, the fatty acid ester is an ethyl or methyl ester. Preferably, the fatty acid ester is a fatty acid methyl ester.

[0039] Therefore, advantageously, the sedative chemical composition comprises a mixture of volatile fatty acid derivatives, the fatty acids being selected from the group consisting of oleic acid, palmitic acid, azelaic acid, pimelic acid, capric acid, lauric acid, myristic acid, palmitoleic acid, linoleic acid, stearic acid, arachidonic acid, n-butyric acid, isobutyric acid, α-methylbutyric acid, caproic acid, pivalic acid, γ-linoleic acid, eicosapentanoic acid, pentadecanoic acid, tridecanoic acid, or docosahexanoic acid, and advantageously, selected from the group consisting of oleic acid, palmitic acid, lauric acid, myristic acid, linoleic acid, stearic acid, and pentadecanoic acid.

[0040] More advantageously, the sedative chemical composition comprises a mixture of volatile fatty acid derivatives selected from the group consisting of methyl oleate, methyl palmitate, methyl azelaate, methyl pimelate, methyl caprate, methyl laurate, methyl myristate, methyl palmitoleate, methyl linoleate, methyl stearate, methyl arachidonic acid, methyl n-butyrate, methyl isobutyrate, methyl α-methylbutyrate, methyl caproate, methyl pivalate, methyl gamma-linoleate, methyl eicosapentanoate, methyl pentadecanoate, methyl tridecanoate, and methyl docosahexanoate, and more advantageously, selected from the group consisting of methyl oleate, methyl palmitate, methyl laurate, methyl myristate, methyl linoleate, methyl stearate, and methyl pentadecanoate.

[0041] The relative proportions of volatile fatty acid derivatives and their sedative chemical composition depend on the target animal.

[0042] If the target animal is a dog, the sedative chemical composition can be selected from those described in international application WO2009144321.

[0043] Certain mixtures of fatty acid esters, preferably methyl esters, for sedating dogs are the following fatty acid esters: • A mixture of oleic acid and n-butyric acid; • A mixture of oleic acid, palmitic acid, and linoleic acid B; • A mixture of oleic acid, palmitic acid, linoleic acid, and palmitoleic acid C; A mixture of capric acid, lauric acid, myristic acid, palmitoleic acid, palmitic acid, linoleic acid, and oleic acid D; • A mixture of oleic acid, palmitic acid, linoleic acid, and myristic acid E; A mixture of oleic acid, palmitic acid, linoleic acid, lauric acid, and myristic acid F; A mixture G of oleic acid, palmitic acid, linoleic acid, myristic acid, and pentadecanoic acid; A mixture of oleic acid, palmitic acid, linoleic acid, myristic acid, pentadecanoic acid, and stearic acid H; • A mixture of oleic acid, palmitic acid, linoleic acid, myristic acid, lauric acid, and pentadecanoic acid I; A mixture of lauric acid, myristic acid, pentadecanoic acid, palmitic acid, stearic acid, oleic acid, and linoleic acid J; A mixture of oleic acid, azelaic acid, pimelic acid, and palmitic acid K.

[0044] A mixture of fatty acid esters, preferably methyl esters, is a mixture of the following fatty acid esters: A mixture containing approximately 55% to 65% oleic acid and 45% to 35% palmitic acid (L); A mixture M containing approximately 45% oleic acid, 16% azelaic acid, 18% pimelic acid, and 21% palmitic acid; A mixture containing approximately 30% palmitic acid, 30% oleic acid, and 40% linoleic acid; A mixture containing approximately 30% palmitic acid, 40% linoleic acid, 10% palmitoleic acid, and 20% oleic acid.

[0045] A specific fatty acid ester mixture P for sedating dogs contains approximately 35% methyl oleate, approximately 2% methyl laurate, approximately 13% methyl stearate, approximately 21% methyl linoleate, approximately 5% methyl myristate, approximately 4% methyl pentadecanoate, and approximately 20% methyl palmitate.

[0046] The inventors of the present invention have further demonstrated that a sedative chemical composition without methyl pentadecanoate produces the same effect on dogs as mixture P. Pentadecanoate is a relatively rare fatty acid in nature, primarily derived from the fat fraction of milk, where it is present in small amounts (1.2%) and is difficult to obtain cheaply. Therefore, the discovery that the sedative effect of the chemical composition is not diminished even without this fatty acid will favorably reduce the costs associated with the manufacture of the device according to the present invention. Accordingly, a further specific mixture Q of fatty acid esters for sedating dogs contains 32% to 38% methyl oleate, 1% to 3% methyl laurate, 13% to 16% methyl stearate, 18% to 24% methyl linoleate, 3% to 7% methyl myristate, and 18% to 24% methyl palmitate.

[0047] A more specific mixture R of fatty acid esters for sedating dogs contains approximately 35% methyl oleate, approximately 2% methyl laurate, approximately 15.5% methyl stearate, approximately 21% methyl linoleate, approximately 5% methyl myristate, and approximately 21% methyl palmitate.

[0048] If the target animal is a cat, the sedative chemical composition can be selected from those described in international application WO2015140631.

[0049] The sedative chemical composition is, for example, a sedative feline pheromone obtained from skin secretions originating from the area between the scapula and ear of a cat.

[0050] Therefore, informational chemical compositions intended to sedate cats may, advantageously, include methyl palmitate, methyl linoleate, methyl oleate, methyl stearate, methyl laurate, and methyl myristate.

[0051] A specific mixture S of fatty acid esters for sedating cats contains 15% to 25% methyl palmitate, 10% to 27% methyl linoleate, 25% to 35% methyl oleate, 5% to 15% methyl stearate, 5% to 15% methyl laurate, and 5% to 15% methyl myristate.

[0052] Another specific mixture T of fatty acid esters for sedating cats contains 19%-26% methyl palmitate, 14%-20% methyl linoleate, 26%-32% methyl oleate, 8%-14% methyl stearate, 8%-14% methyl laurate, and 8%-14% methyl myristate.

[0053] More specifically, mixture U contains 22% methyl palmitate, 17% methyl linoleate, 28% methyl oleate, 11% methyl stearate, 11% methyl laurate, and 11% methyl myristate.

[0054] Another informational chemical composition usable in the device according to the present invention is described in patent US10227321, wherein at least one volatile fatty acid derivative is an ester of the formula shown in Figure 1, where n=0 and R is a saturated or unsaturated linear alkyl group containing 9 to 30 carbon atoms, or n=1 and R is a saturated or unsaturated linear alkyl group containing 8 to 22 carbon atoms.

[0055] The target animals are non-human mammals. These may include pets, such as cats, dogs, ferrets, and rabbits, or livestock, such as rabbits and pigs, that are useful for improving their living conditions. Those skilled in the art will use information chemical compositions in the device according to the present invention that can prevent the manifestation of stress and / or reduce anxiety in a manner appropriate to each target species.

[0056] The amount of information chemical composition within a device can vary considerably. Typically, the proportion of the information chemical composition is between 0.1% and 25% by weight of the total weight of the device. Advantageously, in a collar, the information chemical composition accounts for 1% to 10% by weight, more advantageously 3% to 8% by weight, and preferably about 5% by weight, of the total weight of the collar.

[0057] For the purposes of this invention, "about x%" means a variation of plus or minus 0.2% from a specified percentage.

[0058] The device according to the present invention differs from those described in the prior art, particularly the collar sold under the trademark ADAPTIL®, in that it contains a control factor that can slow down the diffusion of the information chemical composition and controls the diffusion of the information chemical composition outside the device.

[0059] The applicant has demonstrated that it is possible to control the diffusion of an information chemical composition by introducing a material capable of adsorbing the information chemical composition. "Controlling the diffusion of an information chemical composition" is understood to mean releasing a higher relative amount of the information chemical composition and / or releasing it for a longer period of time, and / or releasing a comparable average amount of the information chemical composition over at least two equal time intervals consecutively, for example, releasing about 10% of the information chemical composition over 14 days over at least two periods, compared to the same device without a material capable of adsorbing the information chemical composition. These characteristics result in a higher relative amount of diffusion of the information chemical composition outside the device, relative to the total amount inside the device, compared to prior art devices.

[0060] Control factors for controlling the diffusion of information chemical compositions outside the device include inorganic materials such as clay, diatomaceous earth, and zeolites. Advantageously, clays having a chain structure (amphibole-like silica tetrahedral chains), particularly phyllosilicates, such as wollastonite (e.g., sold under the name Casiflux F75), bentonite, kaolinite, montmorillonite, attapulgite, sepiolite, and palygorskite are used. Attapulgite, sepiolite, and palygorskite are preferred, and sepiolite is more preferred.

[0061] Sepiolite extracted from underground is preferred, but sepiolite that has undergone chemical treatment (e.g., alteration of zeta potential) or heat treatment (e.g., alteration of structure) can also be used.

[0062] A control factor that controls the diffusion of the information chemical composition outside the device is introduced into the device at a rate that varies from 5 to 25% by weight, preferably 10 to 20% by weight, and more preferably about 15% by weight, relative to the total weight of the device.

[0063] The device according to the present invention may include conventionally used components to facilitate the molding of the device, such as fluids, plasticizers, antioxidants, UV inhibitors, or any other components that enable improved stability over time.

[0064] The role of the fluidizer is to facilitate the flow of the mixture into the hopper that supplies it to the extruder screw. Fluidizers are well known to those skilled in the art. The fluidizer is preferably selected from colloidal silica and magnesium stearate, and more preferably colloidal silica.

[0065] The stability of the device according to the present invention, particularly the stability of the components of the information chemical composition, can be improved, for example, by incorporating antioxidants or anti-UV agents.

[0066] Examples of antioxidants include phenolic compounds such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), gallic acid, propyl gallate, and pyrogallol; hydroquinones such as tert-butylhydroquinone (TBHQ) and di-tert-butylhydroquinone (DTBHQ); tocopherol; amines such as octylbutyldiphenylamine (OBPA), poly(1,2-dihydro-2,2,4-trimethylquinoline (Orox PK), N,N'-phenyl-p-phenylenediamine (DPD), and ethoxyquin; and mixtures of these antioxidants. Such compounds are well known to those skilled in the art and can be easily selected. Preferably, the antioxidant used is TBHQ. As a guideline, the amount of antioxidant used may be 0.001% to 0.1%.

[0067] Anti-UV agents make the device material opaque or allow it to absorb UV rays, thus preventing light from reaching the core of the device and limiting the degradation of its components due to light, particularly the degradation of information chemical compositions. Anti-UV agents can be selected from carbon black, aluminum hydroxide (Al(OH)3), calcium carbonate, and hindered amine light stabilizers (HALS), such as those marketed under the name Hostavin N30P®.

[0068] According to certain embodiments, the device according to the present invention further comprises a fluidizing agent such as colloidal silica, and components for improving the time-dependent stability of an information chemical composition such as an antioxidant or an anti-UV agent.

[0069] The proportion of each component in the device is selected so that the diffusion of the information chemical composition is suitable for the desired application, while maintaining the fluid properties of the device (e.g., flexibility or elasticity in the case of an animal collar).

[0070] Therefore, a second object of the present invention is • Polymer matrix, • 0.5% to 10%, preferably about 5%, of the information chemical composition as defined above. • A control factor, preferably about 15%, of the above-defined information chemical composition, which controls the diffusion of the information chemical composition outside the device, in an amount of 5% to 25%. • Optionally 0.001% to 0.1%, preferably about 0.005%, of antioxidants. • Optionally 0.1% to 2%, preferably about 1%, of an anti-UV agent. • A fluid agent in an optional concentration of 0.1% to 5%, preferably about 1.5%. Regarding devices including...

[0071] In the first embodiment, the device according to the present invention is • A polymer matrix consisting of an ethylene-vinyl acetate thermoplastic copolymer. • 0.5% to 10%, preferably about 5%, of the information chemical composition as defined above. • A control factor, preferably about 15%, of the above-defined information chemical composition, which controls the diffusion of the information chemical composition outside the device, in an amount of 5% to 25%. • Optionally 0.001-0.1%, preferably about 0.05%, of antioxidants. • Optionally 0.1% to 2%, preferably about 1%, of an anti-UV agent. • A fluid agent in an optional concentration of 0.1% to 5%, preferably about 1.5%. Includes.

[0072] In a second embodiment, the device according to the present invention is • Polymer matrix, • An information chemical composition comprising 0.5% to 10%, preferably about 5%, of a mixture of fatty acid esters selected from laurate, myristicate, palmitate, stearate, oleate, linoleate, and optionally pentadecanoate. • A control factor, preferably about 15%, of the above-defined information chemical composition, which controls the diffusion of the information chemical composition outside the device, in an amount of 5% to 25%. • Optionally 0.001% to 0.1%, preferably about 0.05%, of antioxidants. • Optionally 0.1% to 2%, preferably about 1%, of an anti-UV agent. • A fluid agent in an optional concentration of 0.1-5%, preferably about 1.5%. Includes.

[0073] In a third embodiment, the device according to the present invention is • Polymer matrix, • 0.5% to 10%, preferably about 5%, of the information chemical composition. A control factor that controls the diffusion of the above-defined information chemical composition outside the device, comprising 5% to 25%, preferably about 15%, and is a clay, particularly phyllosilicate, particularly sepiolite, attapulgite, or palygorskite. The above-mentioned regulatory factors, • Optionally 0.001% to 0.1%, preferably about 0.05%, of antioxidants. • Optionally 0.1% to 2%, preferably about 1%, of an anti-UV agent. • A fluid agent in an optional concentration of 0.1% to 5%, preferably about 1.5%. Includes.

[0074] In a particular embodiment, the device according to the present invention is • A polymer matrix consisting of an ethylene-vinyl acetate thermoplastic copolymer. • An information chemical composition comprising 0.5% to 10%, preferably about 5%, of a mixture of fatty acid esters selected from laurate, myristicate, palmitate, stearate, oleate, linoleate, and optionally pentadecanoate. 5% to 25%, preferably about 15%, of clay, preferably selected from sepiolite, attapulgite and palygorskite. • Optionally 0.001% to 0.1%, preferably about 0.05%, of antioxidants. • Optionally 0.1% to 2%, preferably about 1%, of an anti-UV agent. • A fluid agent in an optional concentration of 0.1% to 5%, preferably about 1.5%. Includes.

[0075] Preferably, the present invention is • A polymer matrix consisting of an ethylene-vinyl acetate thermoplastic copolymer. • An information chemical composition comprising approximately 5% of a mixture of methyl laurate, methyl myristate, methyl palmitate, methyl stearate, methyl oleate, methyl linoleate, and optionally methyl pentadecanoate. • Approximately 15% sepiolite, • Approximately 0.05% antioxidants, • Approximately 1% photoprotective compounds, • Approximately 1.5% fluidizing agent Regarding dog collars, including [specific type of collar].

[0076] In a third embodiment, the present invention has the following effects: • Ensuring the well-being of animals in their environment, • To help animals cope with stress and / or anxiety. • To reduce the stress on animals associated with separation, • To reduce the stress associated with weaning animals, • To reduce the stress on animals associated with loneliness, • To reduce stress on animals before and / or during transport. • To reduce stress caused by noise from thunderstorms or fireworks, • To reduce stress associated with medical conditions requiring examination or even surgery, medical procedures, and visits to the veterinarian. • To reduce animal aggression, • To improve the behavior of animals, especially aggressive or fearful animals. • To give animals a relaxing effect, • Helping animals adapt to new situations (for example, when they are adopted, when a new animal or child is introduced to the environment, when they move to a new house). • To reduce stress-related urinary marking in animals, • To reduce the uncleanliness and filth of animals, • Creating conditions that allow animals to become accustomed to their own kind. • To prevent scratches or destruction of territory. • Reduce sound manifestations such as barking or squealing. • To encourage less aggressive, more relaxed, and more affectionate animal behavior, especially towards their owners. A method for achieving one or more of the following: Preferably, the diffusion of the information chemical composition from the above device over a period of more than one month, more favorably over two months, preferably over a period of about three months, wherein the animal is a dog or a cat. Regarding the above method, the diffusion occurs in animals or in the environment close to animals, that is, in an environment close to the animal's olfactory organs.

[0077] In a fourth embodiment, the present invention has the following effects: • Ensuring the well-being of animals in their environment, • To help animals cope with stress and / or anxiety. • To reduce the stress on animals associated with separation, • To reduce the stress associated with weaning animals, • To reduce the stress on animals associated with loneliness, • To reduce stress on animals before and / or during transport. • To reduce stress caused by noise from thunderstorms or fireworks, • To reduce stress associated with medical conditions requiring examination or even surgery, medical procedures, and visits to the veterinarian. • To reduce animal aggression, • To improve the behavior of animals, especially aggressive or fearful animals. • To give animals a relaxing effect, • Helping animals adapt to new situations (for example, when they are adopted, when a new animal or child is introduced to the environment, when they move to a new house). • To reduce stress-related urinary marking in animals, • To reduce the uncleanliness and filth of animals, • Creating conditions that allow animals to become accustomed to their own kind. • To prevent scratches or destruction of territory. • Reduce vocalizations such as barking or squealing. • To encourage less aggressive, more relaxed, and more affectionate animal behavior, especially towards their owners. The use of the above devices to achieve one or more of the following: Preferably for a period of more than one month, more advantageously for a period of more than two months, preferably for a period of about three months, the animal is a dog or a cat. Regarding the above use.

[0078] The present invention further relates to non-therapeutic methods for sedating animals, in particular, • Ensuring the well-being of animals in their environment, • To help animals cope with stress and / or anxiety. • To reduce the stress on animals associated with separation, • To reduce the stress associated with weaning animals, • To reduce the stress on animals associated with loneliness, • To reduce stress on animals before and / or during transport. • To reduce stress caused by noise from thunderstorms or fireworks, • To reduce stress associated with medical conditions requiring examination or even surgery, medical procedures, and visits to the veterinarian. • To reduce animal aggression, • To improve the behavior of animals, especially aggressive or fearful animals. • To give animals a relaxing effect, • Helping animals adapt to new situations (for example, when they are adopted, when a new animal or child is introduced to the environment, when they move to a new house). • To reduce stress-related urinary marking in animals, • To reduce the uncleanliness and filth of animals, • Creating conditions that allow animals to become accustomed to their own kind. • To prevent scratches or destruction of territory. • Reduce vocalizations such as barking or squealing. • To induce less aggressive, more relaxed, and more affectionate animal behavior, especially towards their owners. • To facilitate the training and / or education of animals. A method for that purpose, The present invention includes applying the device to an animal or an environment close to an animal, i.e., an environment close to the animal's olfactory organs. Regarding the above method.

[0079] The present invention further relates to an information chemical composition as defined above for preventing the manifestation of stress and / or reducing anxiety in pets for a period of more than one month, more preferably more than two months, and preferably about three months, characterized in that it is present within a device according to the present invention.

[0080] In particular, the present invention is for use when sedating animals, • Ensuring the well-being of animals in their environment, • To help animals cope with stress and / or anxiety. • To reduce the stress on animals associated with separation, • To reduce the stress associated with weaning animals, • To reduce the stress on animals associated with loneliness, • To reduce stress on animals before and / or during transport. • To reduce stress caused by noise from thunderstorms or fireworks, • To reduce stress associated with medical conditions requiring examination or even surgery, medical procedures, and visits to the veterinarian. • To reduce animal aggression, • To improve the behavior of animals, especially aggressive or fearful animals. • To give animals a relaxing effect, • Helping animals adapt to new situations (for example, when they are adopted, when a new animal or child is introduced to the environment, when they move to a new house). • To reduce stress-related urinary marking in animals, • To reduce the uncleanliness and filth of animals, • Creating conditions that allow animals to become accustomed to their own kind. • To prevent scratches or destruction of territory. • Reduce vocalizations such as barking or squealing. • To induce less aggressive, more relaxed, and more affectionate animal behavior, especially towards their owners. • To facilitate the training and / or education of animals. For the purposes of, the information chemical composition as defined above, The information chemical composition is contained within the previously defined device. • Polymer matrix, ·Semiochemical composition, • A control factor that controls the diffusion of information chemical composition outside the device. • Depending on the case, antioxidants, • Depending on the case, an anti-UV agent may be used. • Fluids may be used depending on the circumstances The above information relates to a chemical substance composition containing the above information.

[0081] Preferably, the sedative chemical composition is • Polymer matrix, • Information chemical composition containing a mixture of volatile fatty acid derivatives, particularly a sedative information chemical composition, • Control factors that regulate the diffusion of information chemical compositions outside the device. It is administered to animals using a device that includes [the specified component].

[0082] Advantageously, the effects achieved by the device are, • Ensuring the well-being of animals in their environment, • To reduce the stress on animals associated with separation, • To reduce the stress on animals associated with loneliness, • To reduce stress on animals before and / or during transport. • To reduce stress caused by noise from thunderstorms or fireworks, • To reduce stress associated with medical conditions requiring examination or even surgery, medical procedures, and visits to the veterinarian. • Helping animals adapt to new situations (for example, when they are adopted, when a new animal or child is introduced to the environment, or when they move to a new home). Selected from.

[0083] Preferably, according to all of the above embodiments, the pet is a cat or a dog, and preferably the pet is a dog.

[0084] The present invention relates to the use of a control factor that controls the diffusion of an information chemical composition into a polymer matrix, enabling the release of a higher relative amount of the information chemical composition and / or a longer period of time, and / or a continuous equivalent average amount of the information chemical composition over at least two equal time intervals, wherein the release of the higher amount and / or a longer period of time, and / or a continuous equivalent average amount of the information chemical composition over at least two equal time intervals, is measured relative to the amount measured when the same information chemical composition is diffused in the same polymer matrix without the diffusion control factor, and the diffusion control factor is selected from clay, diatomaceous earth, and zeolite. With respect to the above use, the result is a higher relative amount of diffusion of the information chemical composition from the device, relative to the total amount in the device, compared to prior art devices.

[0085] Preferably, The control factors that regulate the diffusion of the information chemical composition outside the device are clay, diatomaceous earth, or zeolite. The information chemical composition is as described above, and is particularly composed of fatty acid esters, preferably fatty acid methyl esters, for example, information chemical compositions A to U. The polymer matrix is ​​a thermoplastic copolymer of ethylene-vinyl acetate. The use of control factors to control the diffusion of the information chemical composition outside the device enables the release of a higher relative amount of the information chemical composition and / or a longer period of release, and / or a continuous release of an equivalent average amount of the information chemical composition over at least two equal time intervals, in particular, the release of a higher amount of the information chemical composition and / or a longer period of release, and / or a continuous release of an equivalent average amount of the information chemical composition over at least two equal time intervals, lasting for a period of more than one month, preferably about three months. • My pet is a dog.

[0086] Advantageously, the control factor for controlling the diffusion of the information chemical composition outside the device is selected from clays having a chain-like structure (chains of silica tetrahedra similar to amphibole), particularly phyllosilicates, such as wollastonite (e.g., marketed under the name Casiflux F75), bentonite, kaolinite, montmorillonite, attapulgite, sepiolite, and palygorskite. Preferably, the factor is attapulgite, sepiolite, and palygorskite, more preferably sepiolite.

[0087] The devices according to the present invention, whatever their form, are prepared by mixing the components that constitute them, and this mixture can then be molded by various means known to those skilled in the art, in particular by extrusion, molding or even 3D printing.

[0088] Manufacturing by molding (and sometimes injection molding) requires melting a mixture of the components that make up the device and then pouring it into a mold with the shape of the finished product. This mold may be coated with a release agent, and the molten mixture cools and solidifies, after which the finished product is removed from the mold. The finished product, once removed from the mold, may be trimmed or polished to remove any imperfections.

[0089] 3D printing is preferably carried out using "Fused Deposition Modeling" (FDM). This technique is based on depositing filaments of a molten mixture of components layer by layer, and the object is given shape by stacking these molten mixtures. The print head moves according to the X, Y, and Z coordinates (length, width, and height) transmitted from a 3D file corresponding to the 3D model of the object to be printed.

[0090] The operating principle of the extrusion manufacturing method is based on forcing a mixture of components into a die. The shape of the die corresponds to the cross-section of the finished part.

[0091] Therefore, the implementation of this extrusion manufacturing method is • Mixing ingredients within the device; • This mixture is extruded through an extruder to produce an extruded product; Optionally, calender the extruded product. • Cut to obtain the finished product Includes.

[0092] According to an exemplary embodiment, the component mixing step involves placing the polymer (preferably 9% EVA) into, for example, a Ploughshare mixer, and then adding the information chemical composition under stirring. This addition can be carried out, for example, by spraying with the ejection of the information chemical composition. Next, a control factor (preferably sepiolite) is added to control the diffusion of the information chemical composition outside the device. Everything is mixed together. Next, if present, a fluidizer is added to the mixture (preferably 1% colloidal silica), the whole is stirred, and the mixture is sieved. A further amount of fluidizer is then added to the sieve and sieved (preferably 0.4% colloidal silica). Finally, the remaining half of the polymer (preferably 9% EVA) is added to an invert mixer, and everything is mixed together again.

[0093] Next, the mixture of components is fed into an extruder, which may be single-screw or twin-screw. If necessary, the extruded web is calendered to obtain the required precise dimensions. Calendering can also be used to cool the extruded web and obtain a solid product.

[0094] The extruded product is in the form of a ribbon, which is then cut to obtain the finished product.

[0095] Figure 1 shows a diagram of volatile fatty acid ester derivatives. Figure 2 shows the time course of fatty acid methyl ester release (Example 2A). [Examples]

[0096] (Example 1: Preparation of a sedation collar for dogs according to the present invention) (Example 1A) The collar device of the present invention comprises a mixture containing an information chemical active ingredient (a mixture R of fatty acid methyl esters including methyl laurate, methyl myristate, methyl palmitate, methyl stearate, methyl oleate, and methyl linoleate), an ethylene-vinyl acetate (EVA) polymer matrix (9% EVA), a clay-type control factor (18.5% montmorillonite) that controls the diffusion of the information chemical composition outside the device, and a fluidizing agent (1% colloidal silica, followed sequentially by 1%).

[0097] Preparation: The first step involves placing half of the polymer (9% EVA) into a Ploughshare mixer, then adding the fatty acid methyl ester mixture by spraying under stirring. Next, montmorillonite is added. Mix the whole mixture for 30 seconds.

[0098] The second step involves adding the fluidizer to the mixture (1% colloidal silica), mixing for 30 seconds, and then sieving the mixture. Afterward, another dose of the fluidizer is sieved into the mixture (1% colloidal silica).

[0099] Finally, add the remaining half of the polymer (9% EVA) to the invert mixer and mix everything for another 3 minutes.

[0100] Next, this mixture is molded by extrusion.

[0101] (Example 1B) The collar device of the present invention comprises a mixture containing an information chemical active ingredient (a mixture R of fatty acid methyl esters including methyl laurate, methyl myristate, methyl palmitate, methyl stearate, methyl oleate, and methyl linoleate), an ethylene-vinyl acetate polymer matrix (9% EVA), a clay-type control factor (15% sepiolite) that controls the diffusion of the information chemical composition outside the device, and a flowing agent (0.1.9% colloidal silica).

[0102] Preparation: In the first step, sepiolite and colloidal silica are mixed in a Ploughshare mixer. Next, the fatty acid methyl ester mixture is added under stirring. The mixture is mixed for 20 seconds and then sieved. The mixture is transferred to an invert mixer containing 9% EVA and mixed for 3 minutes.

[0103] Next, this mixture is molded by extrusion.

[0104] (Example 1C) (Batch D17190), (1D) (Batch D17191), (1E) (Batch D18001), and (1F) (Batch D17207): Collar 1C, 1D, 1E: The collar device of the present invention comprises a mixture containing information chemical active ingredients (methyl laurate, methyl myristate, methyl palmitate, methyl stearate, methyl oleate, and methyl linoleate), an ethylene-vinyl acetate polymer matrix (9% EVA in Examples 1C and 1E, and 16% EVA in Example 1D), a clay-type control factor (15% sepiolite) that controls the diffusion of the information chemical composition outside the device, a fluidizing agent (1% colloidal silica, followed sequentially by 0.4%), an antioxidant (0.005% TBHQ), and an anti-UV agent (1% Hostavin N30P) in Example 1E only.

[0105] Collar 1F: The collar device of the present invention comprises a mixture containing an information chemical active ingredient (a mixture R of fatty acid methyl esters including methyl laurate, methyl myristate, methyl palmitate, methyl stearate, methyl oleate, and methyl linoleate), an ethylene-vinyl acetate polymer matrix (9% EVA), a clay-like control factor that controls the diffusion of the information chemical composition outside the device (15% sepiolite), a fluidizing agent (1.4% colloidal silica), and an antioxidant (0.005% TBHQ).

[0106] Preparation: Examples 1C, 1D, 1E, and 1F were prepared according to the same preparation method.

[0107] Half of the EVA was placed in a Ploughshare mixer. Next, the TBHQ antioxidant was dissolved in a mixture of fatty acid methyl esters, and this mixture was sprayed onto the EVA by a vertical jet under stirring. Sepiolite was then added as a control factor to control the diffusion of the information chemical composition outside the device, and the whole mixture was mixed for 30 seconds. Next, 1% colloidal silica (in example E, + anti-UV agent (Hostavin N30P)) was added while mixing for another 30 seconds. The mixture was then sieved through a 1 mm mesh sieve.

[0108] Next, an additional dose of colloidal silica (0.4%) was sieved into the mixture. Then, the mixture was transferred to the remaining half of the EVA in an inverting mixer. Finally, the whole mixture was mixed for 3 minutes.

[0109] Next, this mixture is molded by extrusion.

[0110] Summary of Examples 1A-1F: [Table 1]

[0111] (Example 2: Characterization of the release profile of a FAME (Factor-Assisted Microorganism) composition) (Example 2A - A study on in vivo release over a one-month period) To measure the release dynamics of information chemical compositions and confirm good local tolerance of collars in animals, a comparative study of different collars containing information chemical compositions was conducted in dogs.

[0112] To that end, three collars of different compositions were tested: a commercially available control collar ADAPTIL® (batch P098663 / 099295), a collar prepared according to Example 1C (batch D17190), and a collar prepared according to Example 1D (batch D17191).

[0113] Therefore, three groups of eight dogs each were fitted with one of three collars for either 14 or 28 days (four dogs per group per period).

[0114] At the end of each period, the fatty acid methyl esters still present in the collar were measured as described in Example 2A.

[0115] The results of the release of fatty acid methyl esters over time are shown in the table and Figure 2 below: [Table 2]

[0116] After 14 days, there was no significant difference in the amount of fatty acid methyl ester released between the control collar and the two collars tested according to the present invention.

[0117] On the other hand, after 28 days, the two collars tested according to the present invention had a low content of fatty acid methyl esters, indicating that the collar according to the present invention had more fatty acid methyl esters available than at 14 days, in contrast to the control collar, which did not show a significant change in the amount of fatty acid methyl ester released.

[0118] Between T0 and T28d, the amount of methyl ester in the collar according to the present invention decreased regularly by 10% per 14-day period, which differs from the case of the control collar.

[0119] (Example 2B - Study on in vivo release over 3 months) A comparative in vivo study over three months was conducted to evaluate the time that the device according to the present invention can release a sedative chemical composition.

[0120] In this study, we compared commercially available control collars, ADAPTIL® batch P100736 / 101294, with batch D18001 (sepiolite + 9% EVA) prepared according to Example 1E.

[0121] Therefore, the 16 dogs were divided into two groups, and each dog wore one of two collars for either one or three months (four dogs per group per period).

[0122] At the end of each period, the active ingredients in the matrix were measured. The results are shown in the table below: [Table 3]

[0123] The results of this study revealed the following: The collar according to the present invention allows for release for at least three months. The collar according to the present invention enables greater availability of information chemical composition compared to a control for at least three months.

[0124] (Example 3: Study of compositional stability over 3 months) To compare the effects of control factors (sepiolite or montmorillonite) that control the diffusion of information chemical compositions outside the device and the levels of vinyl acetate (VA) in the EVA copolymer (9% or 16%), the stability of the first series of formulations was tested over three months. The formulations were stored unpackaged in a climate chamber. [Table 4] [Table 5]

[0125] Sepiolite-based batches showed uniform results throughout stability testing, regardless of whether they were formulations using 9% VA or 16% EVA. EVA-based batches containing montmorillonite and 9% VA showed acceptable stability after 3 months.

[0126] For the first series, this stability demonstrated that over a three-month period, the sepiolite-based batch was more stable in terms of the information chemical composition content.

[0127] Next, the stability of a second series of formulations based on sepiolite, 9% EVA, and several additives (antioxidants, anti-UV agents, dispersants) was tested. In particular, the additives were added separately to investigate their effect on stability. The effects of higher concentrations of the active ingredient were also investigated (5% or 10%). The formulations were stored unpackaged in a climate chamber. Furthermore, formulations stored at 40°C / 75%RH were exposed to ultraviolet light for 8 hours a day for one month during storage. [Table 6] [Table 7]

[0128] For the second series, it was shown that collars exposed to ultraviolet light for 8 hours a day remained stable. Therefore, the presence of anti-UV agents or antioxidants is optional.

[0129] (Example 4: In vivo research: Recognition of efficacy) In particular, to evaluate the effectiveness of the collar according to the present invention, either as a complement to or on its own, a consumer survey was conducted in the homes of dog owners in France.

[0130] Next, dog owners were asked about their awareness of various behavioral standards for their dogs through a questionnaire.

[0131] These dogs were the only dogs in the household, did not live with cats, were over 3 months old, were both male and female, the majority were not neutered / disinfected, were not pregnant or lactating, had no restrictions on outdoor exercise, had no skin problems or skin allergies, and had mild behavioral disorders but were not receiving treatment for them.

[0132] A three-month in-home trial of the collars was conducted. Each household was divided into two groups of 75 dogs in total. One group of 45 dogs wore Batch D18101 collars (the same collar for three months), while the other group of 30 dogs wore both Batch D18101 collars and pest control collars (both collars were worn simultaneously for three months). In each of these groups, 50% of the dogs weighed less than 10 kg, and 50% weighed more than 10 kg.

[0133] At the end of the three-month period, the collars had a positive effect on signs of stress or anxiety throughout the period of wearing them, but no significant differences were observed in the behavior of the dogs in the two groups. It should also be noted that wearing the collar of batch D18101 according to the present invention did not change the effectiveness of the pest control collar, and vice versa.

Claims

1. A device for continuously releasing informational chemical compositions for pets to animals or into the environment surrounding animals, polymer matrix, Information chemical composition containing a mixture of volatile fatty acid derivatives, A control factor selected from clay, diatomaceous earth, and zeolite that controls the diffusion of information chemical composition outside the device. The above devices, including:

2. The device according to claim 1, which is a collar.

3. The device according to claim 1 or 2, wherein the control factor for controlling diffusion is selected from attapulgite, sepiolite, and palygorskite.

4. The device according to any one of claims 1 to 3, wherein a control factor that controls the diffusion of an information chemical composition outside the device is present in the device at a rate that varies from 5 to 25% by weight, preferably 10 to 20% by weight, and more preferably about 15% by weight, based on the total weight of the device.

5. The device according to any one of claims 1 to 4, wherein the polymer matrix is ​​a thermoplastic copolymer of ethylene vinyl acetate.

6. The device according to any one of claims 1 to 5, wherein the information chemical composition comprises a mixture of volatile fatty acid derivatives selected from the group consisting of methyl oleate, methyl palmitate, methyl azelaate, methyl pimelate, methyl caprate, methyl laurate, methyl myristate, methyl palmitoleate, methyl linoleate, methyl stearate, methyl arachidonic acid, methyl n-butyrate, methyl isobutyrate, methyl α-methylbutyrate, methyl caproate, methyl pivalate, methyl gamma-linoleate, methyl eicosapentanoate, methyl pentadecanoate, methyl tridecanoate, and methyl docosahexanoate, and more preferably a mixture of volatile fatty acid derivatives selected from the group consisting of methyl oleate, methyl palmitate, methyl laurate, methyl myristate, methyl linoleate, methyl stearate, and methyl pentadecanoate.

7. The device according to any one of claims 1 to 6, wherein the information chemical composition is a mixture of fatty acid esters comprising 32% to 38% by weight of methyl oleate, 1% to 3% by weight of methyl laurate, 13% to 16% by weight of methyl stearate, 18% to 24% by weight of methyl linoleate, 3% to 7% by weight of methyl myristate, and 18% to 24% by weight of methyl palmitate, based on the total weight of the information chemical composition.

8. The device according to any one of claims 1 to 7, wherein the information chemical composition is 0.1% to 25% by weight of the total weight of the device, preferably 1% to 10% by weight, more preferably 3% to 8% by weight, and more preferably 5% by weight of the total weight of the device.

9. The device according to any one of claims 1 to 8, further comprising a fluidizing agent such as colloidal silica, and a component for improving the time-dependent stability of the information chemical composition, such as an antioxidant or an anti-UV agent.

10. An information chemical composition present in a device according to any one of claims 1 to 9, for use in preventing the manifestation of stress and / or reducing anxiety in pets for a period of more than one month, more preferably more than two months, and preferably about three months.

11. An information chemical composition present in the device according to any one of claims 1 to 9 for use according to claim 10, wherein the pet is a dog.

12. The use of a control factor for controlling the diffusion of an information chemical composition in a device according to any one of claims 1 to 2 and 4 to 9, for enabling the regular diffusion over time and / or diffusion of a higher relative amount of an information chemical composition comprising a mixture of volatile fatty acid derivatives outside a polymer matrix, wherein the regular diffusion and / or diffusion of a higher relative amount is measured relative to the amount measured when the same information chemical composition contained in the same polymer matrix without a diffusion control factor is diffused, and the diffusion control factor is selected from clay, diatomaceous earth, and zeolite.

13. The use according to claim 12, wherein the regulatory factor controlling diffusion is a phyllosilicate selected from attapulgite, sepiolite, and palygorskite.

14. The use according to claim 12 or 13, wherein the polymer matrix is ​​a thermoplastic copolymer of ethylene-vinyl acetate.

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