Synergistic biocidal composition containing polyglycerol esters

Abstract

The present invention provides a disinfectant composition that possesses desired disinfectant properties while using the minimum amount of biocide in the disinfectant formulation. [Solution] A disinfectant composition comprising (i) a biocide; and (ii) a polyglycerol ester, wherein the polyglycerol ester is present in an amount that sufficiently increases the efficacy of the biocide compared to the biocide alone, and the amount of increase is greater than the additive effect of the biocidal activity of the biocide and the polyglycerol ester when used alone.

Description

Technical Field

[0001]

[0002] The present disclosure relates to a biocidal composition having enhanced biocidal properties compared to a composition having a single biocide . Background Art

[0002]

[0004] Disinfectants refer to any chemical agent / composition that can kill, destroy or inhibit the growth of organisms, especially microorganisms . Disinfectant products include hard surface cleaners , hand and skin sanitizers, hand and skin cleaners, pre-disinfection cleaners for instruments, sterile and high-level disinfectant compositions, as well as disinfectants for soft surfaces, such as laundry detergents, fabrics and cleaning and disinfecting agents for upholstery, and the like.

[0003]

[0005] Ideally, a disinfectant composition has broad-spectrum activity against all types of microorganisms at various pH levels. Disinfectant compositions also need to allow the use of minimal amounts of biocides to reduce costs and avoid or reduce adverse effects that may be caused by biocides, so they must also have high potency. In addition, it is desirable that a disinfectant composition is stable against any temperature changes encountered during storage as well as during manufacture, packaging and transportation . Furthermore, an ideal disinfectant composition is physically and chemically compatible with raw materials for different application systems and compatible with different components present in the end-use formulation, so that the disinfectant composition can be suitably incorporated into various end-use products. Summary of the Invention Problem to be Solved by the Invention

[0004] ​

[0006] In recent developments in the field of disinfectants, in order to enhance the efficacy of biocides, / or using the minimum amount of biocide in the disinfectant formulation to achieve the desired disinfectant properties In order to effectively reduce the amount of biocide required for disinfectant compositions containing a toxic composition, Great effort has been made to find compounds that synergistically interact with biocides in the formulation. This disclosure relates to the biocides and polyglycerol ester compounds present in disinfectant compositions. By providing a synergistic mixture of substances, we offer the answer to that need. [Means for solving the problem]

[0005]

[0008] In the first embodiment, (i) a biocide; and (ii) polyglycerol ester. A disinfectant composition containing polyglycerol ester is provided. Polyglycerol ester is used as a biocide alone. In comparison, it is present in an amount that sufficiently increases the efficacy of the biocide, and that increase is not present when used alone. The combined biocide activity of the biocides and polyglycerol esters is greater than the additive effect.

[0006]

[0009] In another embodiment, the weight ratio of polyglycerol ester to biocide is 0.0 The range is 0001 to 10.0, more specifically 0.0001 to 2.0, and even more specifically 0.0 The first embodiment is in the range of 01 to 1.5, and more specifically, in the range of 0.01 to 1.0. A disinfectant composition is provided.

[0007]

[0010] In further embodiments, the disinfectant composition includes a quaternary ammonium compound and a tertiary ammonium compound. Mins, guanides, biguanides, alcohols, phenolic compounds, organic acids, peroxides, peracids Biocides that are iron chelating agents, pyridine compounds, iodine compounds, or mixtures thereof Contains.

[0008]

[0011] In yet another embodiment, in a disinfectant composition, the biocide is N,N-bis( (C8-C16) alkyl groups such as 3-aminopropyl)dodecyl-1,3-propanamine It is a tertiary amine.

[0009]

[0012] In further embodiments, the disinfectant composition is a quaternary ammonium compound. Contains biocides. Quaternary ammonium compounds are alkyl quaternary ammonium compounds. This includes compounds such as benzyl quaternary ammonium compounds. Alkyl quaternary ammonium compounds. Examples of compounds include diC8-18 alkyldimethylammonium compounds or benzyl C8- Contains 18 alkyldimethylammonium compounds. Quaternary ammonium compounds are typical. These include halide ions, carbonate ions, bicarbonate / carbonate ions, carboxylate ions, and sulfate ions. It has a salt anion that is either a phosphate ion or a phosphate ion.

[0010]

[0013] In another aspect of this disclosure, in a disinfectant composition, the biocide is guanide. Anido refers to biguanides, such as polyhexamethylene monoguanide or polyhexa Contains methylene biguanide or chlorhexidine.

[0011]

[0014] In another aspect of the present invention, the biocide may be an acid.

[0012]

[0015] In a further embodiment, the disinfectant composition includes para-chlorometaxylenol, pyridino Biocidal agents include iodine-1-oxide (HPNO), octenidine, or povidone-iodine. It contains an agent.

[0013]

[0016] In another embodiment, the disinfectant composition (a) contains 2 to 12 glycerides based on the average value. (b) polyglycerol components composed of roll molecules, and (b) caprylic acid, capric acid Lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, Derived from fatty acids containing lignoceric acid, cerotic acid, oleic acid, or decaoleic acid. It contains polyglycerol esters. Certain polyglyceryl fatty acid esters are One or more polyglyceryl-10 laurate and polyglyceryl-1 decaoleate 0; Polyglyceryl-3 monostearate; Polyglyceryl-6 distearate, stea Polyglyceryl-10 phosphate; Polyglyceryl-10 oleate; Polyglyceryl dipalmitate Contains Lyceryl-10 or polyglyceryl-10 caprylic / caprate.

[0014]

[0017] In a further embodiment, a method is provided for increasing the efficacy of a biocide in a disinfectant solution. The method comprises the steps of preparing a biocide and using an effective amount of polyglycerol ester. The step includes adding to the biocide, and includes an equal amount of biocide without polyglycerol esters. Compared to physical agents, it increases the efficacy of biocides.

[0015]

[0018] In another embodiment, a method for increasing the efficacy of a disinfectant composition for hard surfaces is provided. The method comprises the steps of providing a disinfectant composition for hard surfaces and providing an effective amount of polyglycerol The process includes the step of adding ester to a disinfectant composition for hard surfaces. The addition of polyglycerol esters, compared to hard surface disinfection compositions without polyglycerol esters, results in a harder surface. To increase the efficacy of surface disinfectant compositions.

[0016]

[0019] In another embodiment, a method for increasing the efficacy of a disinfectant composition for soft surfaces is provided. This method comprises the steps of providing a disinfectant composition for soft surfaces and providing an effective amount of polyglycerol. The process includes the step of adding ester to a disinfectant composition for soft surfaces. The addition of polyglycerol esters, compared to disinfectant compositions for soft surfaces, results in softer surfaces. To increase the efficacy of surface disinfectant compositions.

[0017]

[0020] In a further embodiment of the present invention, the biocides necessary for effective biocidal activity are as follows: A method for reducing small amounts is provided. This method involves the steps of providing a biocide and a certain amount The step of adding polyglycerol ester to a biocide to form a disinfectant composition Includes. The minimum amount of biocide required for effective biocidal activity is polyglycerol ester. In a disinfectant composition having a marker, compared to a composition in which a biocide is used alone, it is more effective. few.

[0018]

[0021] These and other embodiments will become clear when reading the embodiments for carrying out the invention. Ro. [Modes for carrying out the invention]

[0019]

[0023] This discussion describes exemplary embodiments only and does not limit the broader aspects of this disclosure. Those skilled in the art should understand that this is not intended to be done.

[0020]

[0024] Generally, this disclosure relates to disinfectant compositions. Where used herein, the term " Disinfectants are intended to be applied to surfaces to destroy microorganisms that are living on the surface. This means a biocidal composition. The disinfectant compositions of this disclosure have many uses and applications. The disinfectant is suitable for any industry where it is necessary that the surface is essentially free of microorganisms. Alternatively, they may be used in the field. For example, disinfectants may be used in institutional products, household products, or This may include health management products. Disinfectants include, for example, disinfectants for hard surfaces, hand sanitizers, and sterilization agents. or high-level disinfectant compositions, pre-disinfectant cleaners for instruments, disinfectants for soft surfaces, for example This may include disinfectant ingredients in laundry detergents, and cleaners / disinfectants for interior decoration and fabrics. In one specific use, disinfectants are used in the food and beverage sector, on counters and dining tables. It can be used for cleaning food-contact surfaces such as food containers. Generally, it is approved for use in food contact. Disinfectants contain relatively low amounts of biocides.

[0021]

[0025] Surprisingly, a certain amount of polyglycerol ester is used in disinfectant compositions. Adding it to biocides for use creates a phase between the biocide and the polyglycerol ester. It has been found that an effective disinfectant composition with synergistic interactions can be provided. When used in books, "synergistic interaction" refers to the interaction between a biocide and polyglycerol esters. When combined with other substances, the biocidal action of the biocide alone, or the action of the polyglycerol ester alone, is ineffective. This refers to the fact that it has a greater overall effect than its physical properties. In other words, the killing of the material in this disclosure Biological agents are effective against specific microorganisms in the presence of each microorganism at the same concentration. Compared to the antibacterial activity of German antibacterial agents or polyglycerol esters alone, it exhibits greater antibacterial activity. It acts synergistically with polyglycerol esters to achieve bacterial activity. Therefore, while still producing the desired efficacy, the biocides present in the disinfectant composition The amount can be reduced. This effect is also known as potentiation of a biocide in a disinfectant composition . This potentiation of a biocide is also referred to herein as a "synergistic effect" between the biocide and the polyglycerol ester that enhances the efficacy of the biocide.

[0022]

[0026] In one embodiment, the biocide may comprise a quaternary ammonium compound. The quaternary ammonium compound may, for example, be an alkyl quaternary ammonium compound or a benzylammonium compound. The quaternary ammonium compound is also known as "Quat" and typically comprises at least one quaternary ammonium cation together with a suitable anion . Quats generally have the general formula I:

[0023]

Chemical Formula

[0024] .

[0025]

[0027] R 1 , R 2 , R 3 and R 4 groups can vary within a wide range and have antibacterial properties Examples of quaternary ammonium compounds are well known to those skilled in the art. Typically, R 1 , R 2 , R 3 and R 4 two of which are lower alkyl, meaning having 1 to 4 carbon atoms, such as methyl, ethyl, propyl or butyl groups. In addition, R 1 , R 2 , R 3 and and R 4 two of which are longer chain alkyl groups of 6 to 24 carbon atoms, which are straight It may be a chain or branched, or it may be a benzyl group. - is an inorganic acid or M is a monovalent anion or a polyvalent anion of an organic acid. - The anions suitable for this are In principle, these are all inorganic or organic anions, and more specifically, halide ions. For example, chloride ions or bromide ions, carboxylate ions, sulfonate ions, phosphoric acid These are ions, carbonate ions, bicarbonate / carbonate ions, or mixtures thereof. In one embodiment The quaternary ammonium compound may have the following R group: 1 is benzyl or C 6~18 -It is alkyl, R 2 C 1~18 -alkyl or -[(CH2)2- O] n R5 is used, and in the formula, n=1 to 20, R 3 and R 4 C 1~4 - It is an alkyl group, and R5 is hydrogen or an unsubstituted or substituted phenyl group, M - teeth It is a monovalent anion or a polyvalent anion of an inorganic or organic acid.

[0026]

[0028] In one embodiment, the quaternary ammonium compound is dimethyldialkylammonium It may contain dialkylammonium compounds such as dimethylammonium compounds. In one embodiment, dimethylammonium compounds are used. Alkylammonium compounds have approximately 8 to 12 carbon atoms in each alkyl group. It may contain atoms, such as approximately 8 to 10 carbon atoms.

[0027]

[0029] Dimethyldialkylammonium compounds that can be used as primary biocides Examples include dimethyldioctylammonium chloride and other dimethyldioctylammonium compounds. Compounds, such as dimethyldidecylammonium chloride, and dimethyldidecylammonium compounds. This includes compounds such as mixtures. Mixtures of dimethyldialkylammonium compounds may also be used. Other anions, such as those mentioned above, may also be used. Commercially available dimethyldialkyl Ammonium compounds are, for example, produced by Lonza America, BARDAC ( Includes compositions marketed under the trademark name (trademark).

[0028]

[0030] In an alternative embodiment, the first biocide is alkyldimethylbenzylammonium It may contain benzylammonium compounds such as ammonium compounds. Generally, alkyl groups are about 1 It may contain 0 to approximately 18 carbon atoms, for example, approximately 12 to approximately 16 carbon atoms.

[0029]

[0031] Alkyldimethylbenzylammonium compound that can be used as the first biocide Examples of substances include C12 alkyldimethylbenzylammonium chloride and C14 alkyldimethylbenzylammonium chloride. Tylbenzylammonium chloride and C16 alkyldimethylbenzylammonium It contains muchloride. In addition, a mixture of these alkyldimethylbenzylammonium compounds. Compounds may be used. Commercial alkyldimethylbenzylammonium compounds are, for example, Marketed under the trademark name BARQUAT® by Lonza America Inc. These compositions include commercially available alkyldimethylbenzylammonium compounds. This refers to C12, C14, and C16 alkyldimethylbenzylammonium chlorides. It is a blend. Generally, alkyldimethylbenzylammonium compounds are blends. In such cases, higher concentrations of C12 alkyl and C14 alkyl components than C16 alkyl components are used. It is preferable that it contains the above. Other anions containing the above may also be used. Please take note of this.

[0030]

[0032] In another embodiment, the quaternary ammonium is quaternary ammonium propionate. It may contain quaternary ammonium propionates, for example, poly(oxyalkyl) ) May contain ammonium propionate. In a particular embodiment, for example, first killing The compound formulation is N,N-didecyl-N-methyl-poly(oxyethyl)ammonium propio May contain nate.

[0031]

[0033] One particular quaternary ammonium compound is a carbonate of quaternary ammonium cations. Contains salts / bicarbonates. Quaternary ammonium carbonate is given by the following formula:

[0032] [ka]

[0033] (In the formula, R 1 C1~C 20 It is an alkyl or aryl-substituted alkyl group, R 2 C8~C 20 It is an alkyl group, preferably R 1 is R 2 It is the same as R 1 C 8~C 12 It can be represented by (being an alkyl group), and similarly the composition is the corresponding quaternary bicarbonate. Ammonium

[0034] [ka]

[0035] (In the formula, R 1 C1~C is the same as or different from the above.20 Alkyl or aryl substituted It is an alkyl group, R 2 C8~C is the same as or different from the above. 20 It is an alkyl group However, R is preferable. 1 is R 2 It is the same as R 1 C8~C 12 (It is an alkyl group) It also includes.

[0036]

[0034] In one embodiment, the first biocide contained in the composition is carbonic acid / bicarbonate diC 8~C 12 Contains alkylammonium. For example, in a particular embodiment, antibacterial or The preservative composition is made of didecyldimethylammonium carbonate and didecyldimethylammonium bicarbonate. It contains ammonium monium.

[0037]

[0035] In other embodiments, however, quaternary ammonium cation carbonate / heavy carbon Salts include dioctyldimethylammonium carbonate and decyloctyldimethylammonium carbonate. Benzalkonium carbonate, benzethonium carbonate, stearalkonium carbonate, cetriol carbonate Monium, behentrimonium carbonate, dioctyldimethylammonium bicarbonate, dioctyldimethylammonium bicarbonate Siloctyldimethylammonium, benzalkonium bicarbonate, benzethonium bicarbonate, Stearalkonium bicarbonate, cetrimonium bicarbonate, behentrimonium bicarbonate, and A mixture of one or more such carbonates may be selected.

[0038]

[0036] In addition to the quaternary ammonium compounds listed above, other compounds and oligo Mer and polymer materials have one or more quaternary ammonium groups and are also biocidal. It can be used as an agent. One such example is two quaternary compounds linked by a linking group. "Gemini" quaternary ammonium compounds, also known as di-quaternary ammonium compounds having an ammonium group. It is a gemin quat. An example of a gemin quat is, for example, the general formula:

[0039] [ka]

[0040] It contains quaternary ammonium compounds. R1, R2, R3, R4, R5, R6 and R7 are Examples of quaternary ammonium compounds that can vary over a wide range and possess antibacterial properties include: This is well known to those skilled in the art. Typically, two of R1, R3, and R5, as well as R2 and R4 And two of R6 are lower alkyl groups, methyl, ethyl, propyl, or butyl This means that it has 1 to 4 carbon atoms, such as a group. In addition, R1, R3, R5 At least one of the following, and at least one of R2, R4 and R6, is 6-2 It is a longer-chain alkyl group or benzyl group consisting of four carbon atoms. - is an inorganic acid or X is a monovalent anion or a polyvalent anion of an organic acid. - or M - Suitable for Anions are, in principle, all inorganic or organic anions, and more specifically, halogens. Ions such as chloride ions or bromide ions, carboxylate ions, and sulfonate ions. These are phosphate ions, carbonate ions, bicarbonate / carbonate ions, or mixtures thereof. An example of a germinator is bis(2-N,N-dimethyl-N-alkylammonium ethyl It is an ether dichloride.

[0041]

[0037] In another embodiment, the biocide may include an amine. The amine is, for example, a bactericide. In particular, when controlling the growth of Gram-negative bacteria, a synergistic interaction with quaternary ammonium carbonate is observed. It was found that it possesses. Preferred amines are tertiary amines such as (C8-C14) alkylamines. This includes, but is not limited to, C8-C14 alkylamines. It includes all amines containing (C1-C14) alkyl groups. 4) The alkylamine is N,N-bis(3-aminopropyl)dodecylamine, L Obtained from onza as Lonzabac® 12.30 and 12.100. It is possible.

[0042]

[0038] Other exemplary tertiary amines include, for example, N-(3-aminopropyl)-N-do Sil-1,3-propanediamine, N-(3-aminopropyl)-N-decyl-1,3- Propanediamine, N-(3-aminopropyl)-N-tetradecyl-1,3-propane Diamine, N-(3-aminopropyl)-N-octyl-1,3-propanediamine, N -(3-aminopropyl)-N-hexadecyl-1,3-propanediamine; similarly this These include acid addition compounds. Other similar tertiary amines may be used.

[0043]

[0039] In one embodiment, the biocide is guanidine, more specifically biguanide and / or This may include substitution products, salts, analogs, derivatives, and / or combinations thereof. Anidos are known to exist in other forms, but generally they are expressed by the following formula.

[0044] [ka]

[0045] (In the formula, R 1 , R 2 , R 3 and R 4 Each of these is independently substituted with hydrogen, of arbitrary choice. alkyl, optionally substituted phenyl, ethylene glycol, diethylene glycol Selected from , methylene glycol and tetraethylene glycol, or R 1 , R 2 , R 3 and R 4 One of them is

[0046] [ka]

[0047] (In the formula, R 5 , R 6 and R 7 These are, independently, hydrogen and optionally substituted aluminum. Kill, optionally substituted phenyl, ethylene glycol, diethylene glycol, (May be selected from ethylene glycol and tetraethylene glycol) The substituents of alkyl and phenyl groups are halogens, e.g., chloro, bromo, fluorine. Alkyl alkyl groups include, but are not limited to, iodine, hydroxyl, and amino compounds. It may have 1 to 6 carbon atoms, and may be saturated or unsaturated, linear or branched. .

[0048]

[0040] In one embodiment, the biocide is a polymer biguanide or polybiguanide This may include known substances, or their salts, analogs, or derivatives. In one embodiment, Polybiguanides may be copolymers or heteropolymers. The polymer may be linear, branched, cyclic, and / or dendrimer. The digits can range from 2 to 1,000, for example, 5 to 750, 10 to 500, 25 to 250, etc. However, it can vary in repeating units such as 50 to 100. In one particular embodiment, polybiguan Nido is polyhexamethylene biguanide (PHMB), polyhexamethylene monoguanide (PHMG), polyethylene biguanide (PEB), polytetramethylene biguanide (P TMB), polyethylene hexamethylene biguanide (PHMB), polymethylene biguanide (PMBs), poly(allyl biguanide ni-co-allylamine), poly(N-vinyl - May contain biguanides, polyallyl biguanides, etc.

[0049]

[0041] For example, in one particular embodiment, the biocide is polyhexamethylene biguanide It may contain any of the polyalkylene biguanides. In one embodiment, the biocide is polyaminop Polyhexamethylene biguanide hydrochloride (P), also known as ropirubiguanide (PABP). May contain HMB. PHMB has various terminal groups including guanidine (not shown). It is known to exist as a composite mixture of polymer biguanides, but generally the following The formula

[0050] [ka]

[0051] It is represented by [this]. The n value represents the number of repeating units in the biguanide polymer.

[0052]

[0042] More specifically, PHMB has terminal groups, for example, amines, cyanoguanidinos, and This can be a mixture of various biguanide polymers that may contain different combinations of guanidine. Based on these three terminal groups alone, at least six possible biguanide polymers can be formed. It is possible that one biguanine with two terminal amine groups, called PHMB-AA, may exist. A polymer called PHMB-CGCG, which has two terminal cyanoguanidino groups. and PHMB-GG, which have two terminal guanidine groups (see below for more information). (Referring to the term) There may be three possible biguani with two different combinations of terminal groups. Dopolymers also exist. Furthermore, based on the terminal groups mentioned above, they are amine-cyano Guanidino (PHMB-ACG), amine-guanidino (PHMB-AG), and guani It contains din-cyanoguanidino (GCG). Therefore, the PHMB sample is the 3 mentioned. It may include a mixture of polymeric biguanides having terminal groups. Furthermore, several compositions This may include a chain-like polymer guanide (not shown). The subscript "n" indicates a repeating group. The average length is shown, and the distribution of polymer length is as follows for each polymer:

[0053] [ka]

[0054] (In the formula, n can be approximately 1 to approximately 50, for example, approximately 1 to approximately 20.)

[0055]

[0043] Polyhexamethylene biguanides such as polyhexamethylene biguanide hydrochloride are It has a broad antibacterial range and is fast-acting. Furthermore, the antibacterial agent is stable over a wide pH range. ru.

[0056]

[0044] In one embodiment, the biocide may include a bis-biguanide. It is known to exist in other forms, but generally it is given by the following formula:

[0057] [ka]

[0058] (In the formula, A and A 1 Each of these (1) optionally contains 1 to approximately 4 carbon atoms. A phenyl group substituted with an alkyl or alkoxy group, a nitro group, or a halogen atom (2) Nyl group; (3) Alkyl group containing 1 to about 12 carbon atoms; or (4) 4 to about 12 Represents any of the alicyclic groups containing carbon atoms; X and X 1 These are 1 to 3, respectively. Represents an alkylene group containing carbon atoms; Z and Z 1 These are 0 or 1 respectively. It could be either; R and R 1 These are, respectively, hydrogen or 1 to approximately 12 carbon atoms. Alkyl groups containing carbon atoms, or aralkyl groups containing 7 to approximately 12 carbon atoms Represents one of the following; n is an integer including 2 to 12; chain (CH2) n This is optional, oxygen Alternatively, it may be interrupted by a sulfur atom, an aromatic nucleus, or by a halide, hydroxyl Even if substituted with alkyl, alkenyl, alkynyl, or acetyl groups, aromatic nuclei, etc. (Good) is represented as. In one embodiment, the chain (CH2) n This is optional, and uses a divalent crosslinking group. It may be replaced, and the divalent bridging group may be replaced with an oxygen or sulfur atom, an aromatic nucleus, etc. Alkylenes, alicyclic groups, cyclic nuclei, aromatic nuclei, etc., which may be selected to be interrupted or removed. However, it is not limited to these. Exemplary bis-biguanide compounds include chlorhexidine. Alexidine, trifluoromethylphenyl bis-biguanide, their analogues, and derivatives This includes, but is not limited to, salts, and / or other salts.

[0059]

[0045] In one particular embodiment, the biocide is chlorhexidine or a derivative thereof. It may contain salts. Chlorhexidine is generally expressed by the following formula

[0060] [ka]

[0061] It is represented as follows.

[0062]

[0046] In one embodiment, the biocide may include a chlorhexidine salt. For example, The agents are chlorhexidine gluconate, chlorhexidine hydrochloride salt, or chlorhexidine acetate. It may contain gin.

[0063]

[0047] In one embodiment, the biocide may include a biguanide salt. For example, in one embodiment Biocides include biguanides, polybiguanides, bisbiguanides, their derivatives, and This may include inorganic or organic salts of the and / or analogues. In a particular embodiment, the biocide , may include biguanides, polybiguanides, and / or halogenated bis-biguanides. ;Contains chlorides, bromides and iodides;Hydrochlorides;Sulfates;Gluconates;Acetates;Shu Succinates; succinates; tartrates; phosphates; phosphates; phosphonates; nitrites; nitrates Salt; carbonate; sulfate; sulfonate; alkyl sulfonate; phenyl sulfonate; amino Carboxylate salts; carboxylate salts; hydroxycarboxylate salts; organic phosphates; organic phosphonic acids This includes salts; organic sulfonates; organic sulfates, etc., and combinations thereof.

[0064]

[0048] In another embodiment, the biocide may include a metal complex of a biguanide. For example, biocides include iron, zinc, nickel, chromium, cadmium, ruthenium, and Lydium, Mendelevium, Silver, Osmium, Silicon, Platinum, Manganese, Cobalt, Copper, boron, technetium, rhenium, palladium, vanadyl, and combinations thereof. Select from the group including seto-complexed biguanides, their derivatives, and / or analogs. These are possible, but not limited to them.

[0065]

[0049] In one embodiment, the biocide is dimethoxyphenyl biguanide, aryl biguanide Nido, N-arylated biguanide, N-alkylated biguanide, N,N-disubstituted biguanide Dimethyl-biguanide (metformin), N-(4-chlorophenyl)-N'-( Sopropyl)-imidodicarbonimidodiamide (proguanil), 1-[amino-( 3,4-Dichloroanilino)methylidene]-2-propane-2-ylguanidine (chlor -Proguanil), 1-butyl biguanide (buformin), phenethyl biguanide (phenethylbiguanide) (Nformin), pyrimethamine, phenanthridine biguanide, arylmethyl biguanide , and may include biguanides selected from the group including chlorophenyl biguanides.

[0066]

[0050] Another biocides available in this disclosure include phenol compounds. The phenol compound is parachlorometaxylenol ("PCMX"). PCMX is, PCMX is effective against both Gram-positive and Gram-negative bacteria. Lenol; 4-chloro-3,5-xylenol; 4-chloro-3,5-dimethylphenol ;2-chloro-m-xylenol;2-chloro-5-hydroxy-m-xylene;2- LOLO-5-hydroxy-m-xylene; 2-chloro-5-hydroxy-1,3-dimethyl Benzene; 4-chloro-1-hydroxy-3,5-dimethylbenzene; and 3,5-di It is sometimes called by other names, including methyl-4-chlorophenol. Typical amounts are... This is up to approximately 3% by weight of the poison composition.

[0067]

[0051] Another biocides available in this disclosure include alcohol compounds. Alcohols are, Typically, monofunctional low molecular weight alcohols, preferably methanol, ethanol, isopropyl alcohol. Alkanols having 1 to 4 carbon atoms, such as panol or butanol, or A combination of these is selected. Particularly preferred alcohols are ethanol and isopropyl alcohol. Contains alcohol.

[0068]

[0052] The biocide may also be an organic acid compound. The organic acid is at least one mo These may also be organic acids of nocarboxylic acid or polycarboxylic acid. Such may be saturated Any monocarboxylic acid or polycarboxylic acid that is water-soluble, even if unsaturated. It may also be the case that the organic acid component is a compound having the formula: R-COOH, in the formula R is hydrogen, lower alkyl; substituted lower alkyl; hydroxy lower alkyl; CAL Boxy lower alkyl; carboxy, hydroxy lower alkyl; carboxy, hydroxy lower alkyl Kill; carboxy, dihydroxy lower alkyl; dicarboxy, hydroxy lower alkyl Carboxylated lower alkenyl; dicarboxylated lower alkenyl; phenyl; substituted phenyl Yes, substituted lower alkyls include halogens, hydroxyls, aminos, thiols, and nitros. Substituted with one or more groups consisting of cyano and a typical acid. Examples include monocarbons such as formic acid, acetic acid, chloroacetic acid, lactic acid, ascorbic acid, and salicylic acid. Acids; dicarbons such as fumaric acid, malonic acid, succinic acid, glutaric acid, itaconic acid, and tartaric acid. Acids; tricarboxylic acids such as citric acid; said acids, either alone or as mixtures thereof. It may be used in this way.

[0069]

[0053] Other biocides available in this disclosure include peroxide compounds. Exemplary peroxides This includes, for example, a hydrogen peroxide source used in the present invention, an aqueous hydrogen peroxide solution, and sodium percarbonate. Um, potassium percarbonate, sodium perborate and potassium perborate, hydrogen peroxide urea, Similarly, this includes, but is not limited to, these hydrates and mixtures thereof. In this application method, the hydrogen peroxide source is approximately 0.5% to 50% by weight of aqueous peroxide dissolved in water. It is an aqueous solution containing an element. In another embodiment, the hydrogen peroxide source is a solid of sodium percarbonate. It may also be a compound.

[0070]

[0054] In addition to hydrogen peroxide-based disinfectants, peracid-based disinfectants may also be used. When used, the term "peroxy acid" refers to a hydroxyl group where the hydrogen atoms are hydroxyl. This refers to acids substituted with a roxy group. Oxidizing peracids are, in this specification, peroxycarboxylic acids. It is called [name]. Conventional peroxycarboxylic acid compositions are formed through an acid-catalyzed equilibrium reaction. However, acid-catalyzed equilibrium reactions are commonly used to produce peroxycarboxylic acids. It is a peroxycarboxylic acid (or percarboxylic acid) that is generally given by formula R(CO It has 3H)n, where, for example, R is alkyl, arylalkyl, cycloalkyl, It is an aromatic or heterocyclyl group, where n is 1, 2, or 3, and precedes the acid. It is named by adding "ruoxy". The R group can be saturated or unsaturated, as well as substituted or It may be non-substitutable.

[0071]

[0055] Further examples of disinfectants include iron chelating agents, bispyridine compounds and iodine compounds. Includes substances. Examples of iron chelating agents include compounds such as pyrithione compounds and piroctone compounds. Contains compounds such as lamin or hydroxylpyridine compounds and their salts. ON is 2-mercaptopyridine-N-oxide; 2-pyridinethiol-1-oxide ( It is known by several names, including CAS Registry Number 1 121-31-9. Other iron cutters Examples of anticoagulants include 1-hydroxypyridine-2-thione and 1-hydroxy-2(1H )-Pyridinethione (CAS Registry Number 1 121-30-8); 2-Pyridine-1 -Oxide (HPNO) and N-hydroxy-6-octyloxypyridine 2(1H) -ONE and -hydroxy-6-octyloxypyridine 2(1H)-ONE ethanol Contains min salt. Pyrithione salt is OMADINE sodium® or OMAD INE Zinc (registered trademark), for example, 2-pyridinol-1-oxide (HPNO) Such pyridinol compounds are commercially available from Lonza. Bispyridine compounds are It contains compounds such as octenidine. Iodine compounds include compounds such as povidone-iodine. nothing.

[0072]

[0056] In addition, biocides include a single biocide, and two or more types of biocides. It may be a mixture of physical agents, or a mixture of two or more different types of biocides. This is also fine. For example, a biocide is a mixture of different quaternary ammonium compounds, quaternary ammonium A mixture of ammonium compounds and amines, a mixture of quaternary ammonium compounds and biguanides, and Other similar mixtures may also be used.

[0073]

[0057] In one embodiment, the polyglycerol esters available for use in this disclosure are saturated, unsaturated It can be formed from natural or synthetic fatty acids, for example, saturated fatty acids such as caprylic acid. Capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid This includes behenic acid, lignoceric acid, cerotic acid, combinations thereof, and derivatives thereof. Furthermore, polyglycerol esters (a) have 2 to 12 glycerols based on the average value. (b) polyglycerol components composed of cellulose molecules, and (b) caprylic acid, capric acid, cellulose Uric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lig A group consisting of noceric acid, cerotic acid, oleic acid, decaoleic acid, and mixtures thereof. It is derived from fatty acids selected from.

[0074]

[0058] An example of a polyglycerol ester usable in this disclosure is poly monodecaoleate. Glyceryl, e.g., polyglyceryl-10 decaoleate; polyglyceryl monooleate For example, polyglyceryl-2 monooleate, polyglyceryl-3 monooleate, Polyglyceryl-4 oleate, polyglyceryl-6 monooleate, or monooleate Polyglyceryl-10 dioleate; polyglyceryl dioleate, e.g., polyglyceryl dioleate Lyceryl-2, Polyglyceryl-3 Dioleate, Polyglyceryl-5 Dioleate, Di Polyglyceryl-6 oleate or polyglyceryl-10 dioleate; triolein Polyglyceryl acids, for example, polyglyceryl-5 trioleate or polyglyceryl trioleate Glyceryl-10; polyglyceryl tetraoleate, e.g., polyglyceryl tetraoleate Ceryl-2, polyglyceryl-6 tetraoleate, or polyglyceryl tetraoleate Lyl-10; Polyglyceryl pentaoleate, e.g., Polyglyceryl pentaoleate -4, Polyglyceryl-6 pentaoleate, or Polyglyceryl- 10; Polyglyceryl heptaolate, e.g., polyglyceryl-6 heptaolate, Polyglyceryl-10 heptaoleate; polyglyceryl monostearate, e.g., mono Polyglyceryl-2 stearate, polyglyceryl-3 monostearate, monostearate Polyglyceryl-4 monostearate, polyglyceryl-5 monostearate, poly Glyceryl-6 or polyglyceryl-10 monostearate; polyglyceryl distearate Ceryl, for example, polyglyceryl-2 distearate, polyglyceryl-3 distearate Polyglyceryl-4 distearate, polyglyceryl-6 distearate, or dis Polyglyceryl-10 thearate; polyglyceryl tristearate, e.g., tristea Polyglyceryl-4 phosphate, polyglyceryl-5 tristearate, polyglyceryl-5 tristearate Liglyceryl-6, or polyglyceryl-10 tristearate; tetrastearate Polyglyceryl, e.g., polyglyceryl-2 tetrastearate; polyglyceryl-2 pentastearate Liglyceryl, for example, polyglyceryl-4 pentastearate, poly Glyceryl-6, or polyglyceryl-10 pentastearate; heptastearate Polyglyceryl, e.g., polyglyceryl-10 heptastearate; polyglyceryl isostearate Liglyceryl, for example, polyglyceryl-2 isostearate, polyglyceryl isostearate Ceryl-3, Polyglyceryl-4 Isostearate, Polyglyceryl- 6, or polyglyceryl-10 isostearate; polyglyceryl diisostearate For example, polyglyceryl-2 diisostearate, polyglyceryl- 3. Polyglyceryl-4 diisostearate, Polyglyceryl-6 diisostearate, Polyglyceryl-10 diisostearate, or polyglyceryl- 15; Polyglyceryl triisostearate, e.g., polyglyceryl triisostearate 2, Polyglyceryl-3 Triisostearate, Polyglyceryl Triisostearate Lu-5, Polyglyceryl-10 Triisostearate; Polyglyceryl-10 Tetraisostearate Ceryl, e.g., polyglyceryl-2 tetraisostearate; polyglyceryl caprylate For example, polyglyceryl-2 caprylate, polyglyceryl-3 caprylate, poly Liglyceryl-4, polyglyceryl-6 caprylate, or polyglyceryl- 10; Polyglyceryl dicaprylate, e.g., polyglyceryl-5 dicaprylate; sesquicarbonate Polyglyceryl sesquicaprylate, e.g., polyglyceryl-2 sesquicaprylate; octacaprylate Polyglyceryl acids, e.g., polyglyceryl-6 octacaprylate; polyglyceryl caprate For example, polyglyceryl-2 caprate, polyglyceryl-3 caprate, caprin Polyglyceryl-4 acid, polyglyceryl-5 caprate, polyglyceryl-6 caprate Polyglyceryl-10 caprate, polyglyceryl dicaprate, for example, dicaprate Polyglyceryl-3 or polyglyceryl-6 dicaprate; caprylic / caprate Liglyceryl, e.g., polyglyceryl-4 caprylate / caprate, caprylate / caprate Polyglyceryl-6 caprate, or polyglyceryl-10 caprylic / capric acid; palmitate Polyglyceryl palmitate, for example, polyglyceryl-2 palmitate, polyglyceryl palmitate Ceryl-3, polyglyceryl-6 palmitate, or polyglyceryl-10 palmitate ; Polyglyceryl dipalmitate, e.g., polyglyceryl-6 dipalmitate or Dipa Polyglyceryl-10 lumitate; polyglyceryl tetrabehenate, e.g., tetrabehenate Polyglyceryl-6 acid; polyglyceryl myristate, for example, polyglyceryl myristate ru-6 or polyglyceryl-10 myristate; polyglyceryl phosphate-cinoleate, e.g. For example, polyglyceryl-6 polyphosphocinoleate or polyglyceryl-phosphocinoleate 10; including, but not limited to, mixtures thereof, other complexes or derivatives thereof. It is not determined.

[0075]

[0059] Preferably, the polyglycerol ester is one or more decaoleates Glyceryl-10, Polyglyceryl-3 Monostearate, Polyglyceryl Distearate Lu-6, Polyglyceryl-10 Stearate, Polyglyceryl-10 Oleate, Dipal Polyglyceryl-10 Mitinate, Polyglyceryl-10 Caprylic / Capric Acid; and These may be mixtures. In one embodiment, the polyglycerol ester is caprylic acid / capric acid. It is polyglyceryl-10 phosphate.

[0076]

[0060] In this disclosure, the weight of polyglycerol ester (PGE) and biocide (BA) The ratio typically ranges from approximately 0.00001 to approximately 10.0 (PGE / BA). When used in detailed documents, "weight ratio" refers to the amount of polyglycerol ester versus the amount of biocide. It is calculated by dividing by (for example, a weight ratio of 10 is the same as 10 PGE:1 BA) (Yes). More typically, polyglycerol esters (PGE) and biocides (BA) The weight ratio is typically in the range of approximately 0.0001 to approximately 2.0, more typically 0.001 to The weights of PGE and BA are 1.5 and, more specifically, in the range of 0.01 to 1.0. The ratio may be any quantity between the minimum and maximum values. For example, the ratio may be 0.00001 ~2.0;0.0001~1.5;0.00001~1;0.00001~0.5;0. 0001~10;0.0001~1.5;0.0001~1;0.0001~0.5;0 .001~10;0.001~1.5;0.001~1;0.001~0.5;0.01 It is also acceptable for the values ​​to be between ~10; 0.01~1.5; 0.01~1; and 0.01~0.5.

[0077]

[0061] The amount of biocide used in the disinfectant composition of this disclosure varies depending on the biocide. Used in quantities. For example, quats, biguanides, and amines are typically used in their final use. It is used in amounts less than 5% by weight in the formulation. It is used as a disinfectant according to the "final use formulation". This refers to the intended formulation when used. Other biocides such as alcohol are intended for use in the final product. Depending on the formulation used, it may be present in the final used formulation in amounts of up to 50% by weight or more. Depending on the biological agent, the maximum amount of a particular agent is regulated by different national and regional regulations. It is considered.

[0078]

[0062] The biocide is a quaternary ammonium compound, an amine, a biguanide, or a mixture thereof. In the case of a compound, the final used compound is generally around 10 ppm (parts per million) to 10,000 ppm. It contains biocides with a total PM content. For example, biocides are typically used in the final use distribution. In the mixture, it is present in amounts of approximately 50 ppm to 5000 ppm, more typically 100 ppm to 30 ppm. It exists in an amount of 00 ppm.

[0079]

[0063] In an alternative embodiment, the disinfectant may be in the form of a disinfectant concentrate. The term "concentrate" refers to a composition that can be diluted with a solvent before use. In disinfectant concentrates, The amount of biocide used is greater than the typical final use. Therefore, disinfectants are typically provided as disinfectant concentrates. Dilution of disinfectant concentrates is performed as follows: Typically, an aqueous solvent is used before use. One specific aqueous solvent that may be used is water. Dilution is performed to dilute the concentrate to the desired level of the active ingredient for its intended use. Therefore, any amount of solvent may be required. A set amount of concentrate is added to a specific amount of solvent. This is typical. For example, 28.35g (1 ounce) of concentrate can be used in 0.47L (1 cubic meter). It can be added to the solvent (of the product) to a dilution ratio of 1:16; 28.35 g (1 ounce) of concentrate. However, it can be added to 0.95 L (1 quart) of solvent, resulting in a dilution ratio of 1:32, with a concentration of 28.35. One g (1 ounce) of concentrate can be added to 1.89 L (1 / 2 gallon) of solvent, in a 1:6 ratio. Dilute to a ratio of 4; add 28.35g (1 ounce) of concentrate to 3.78L (1 gallon) of water. It can be added, resulting in a dilution ratio of 1:128, for example. Similarly, metric dilution ratios can also be used. For example, this could be done with a dilution ratio of 1:100, such as 10 ml per liter.

[0080]

[0064] When contained in disinfectant products, biocides and polyglycerol esters are It may be combined with various different components. For example, in one embodiment, the solvent is in the product. It can be present in. Generally, the solvent is a polar solvent such as water, or an alcohol and / or These are water-miscible solvents such as glycol ethers. In addition to water, the antimicrobial composition is further water-miscible. It may contain water-miscible organic solvents. Examples of water-miscible solvents include ethanol, propanol, and benzyl Alcohol, phenoxyethanol, isopropanol, diethylene glycol propyl Ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether Tel, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl Ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether Diethylene glycol monobutyl ether, diethylene glycol monoethyl ether Ethylene glycol mono-n-butyl ether, ethylene glycol dimethyl Ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether propylene glycol n-butyl ether, tripropylene glycol methyl ether , dipropylene glycol methyl ether, dipropylene glycol butyl ether and This includes combinations of these.

[0081]

[0065] In addition to the solvent, the disinfectant product may contain a surfactant. Typically, a surfactant The agent is a nonionic surfactant or a cationic surfactant. The surfactant is a disinfectant. It is present in the concentrate in an amount of approximately 1% to 20% by weight. Typically, surfactants are present in the concentrate. This is between 2% and 15% by weight.

[0082]

[0066] Particularly preferred surfactants are alkoxylated alcohol surfactants, and generally It has approximately 2 to 8 moles of alkoxylation. Typically, it has 3 to 6 moles of alkoxylation. Yes, there is. One specific example is the alkoxylation of approximately 4.5 moles. In addition to doing so, alcohols that are alkoxylates are C4-C12 alkyl alcohols. It is a C8-C10 alkyl alcohol. In one embodiment, the alkyl alcohol is a C8-C10 alkyl alcohol. Alkoxylation may also be ethoxylation. Generally, H in the range of 8 to 14 LB (Hydrophilic-Lipophilic Balance), more generally 10-12, for example, having an HLB of about 11. It is desirable.

[0083]

[0067] Nonionic surfactants that can be used in the present invention include polyoxyethylene glycol Alkyl ethers, octaethylene glycol monododecyl ethers, pentaethylene glycol Recall monododecyl ether, polyoxypropylene glycol alkyl ether, Glucoside alkyl ethers, decyl glucosides, lauryl glucosides, octyl glucosides Polyoxyethylene glycol octylphenol ether, polyoxyethylene Recall alkylphenol ether, glycerol alkyl ester, glycerol laurate Ceryl, polyoxyethylene glycol sorbitan alkyl ester, sorbitan alkyl Polyester, dodecyldimethylamine oxide, polyethylene glycol and polypropylene Block copolymers of glycols, poloxamers, and polyethoxylated taluamines (POEA), and mixtures thereof, including but not limited to non- The amount of ionic surfactant is approximately 1-8% by weight of the formulation. Typically, concentrates are used. It contains 2-5% by weight of nonionic surfactant. Nonionic surfactant in ready-to-use products. The amount of the surfactant is about 0.05 to about 3% by weight of the solution. In another embodiment, in the product The nonionic surfactant is present in a concentration of approximately 0.05 to 1.5% by weight of the solution. Typically, The poisonous product contains 0.06 to 1% by weight of a nonionic surfactant.

[0084]

[0068] In addition, the disinfectant product contains an optional metal ion chelating agent (Sequesterin It may contain a metal ion chelating agent. For example, ethylenediaminetetraacetic acid. Selected from the group consisting of (EDTA), nitrilotriacetic acid (NTA), and tetrasodium EDTA. It contains acetic acid derivatives. The ability of NTA and EDTA to remove metal ions is related to hardness ( The solution is facilitated by preventing the precipitation of calcium. Metal ion chelating agents are also present in the composition. It may also help to bind with other metal ions that could negatively affect the effectiveness of disinfectant components. In addition, metal ion chelating agents also contribute to the removal and / or disinfection composition during use. It can also help prevent the re-adhesion of contaminants. Metal ion chelating agents are present in the concentrate. Generally, it is present in amounts up to about 20% by weight, and typically in amounts of about 2 to about 8% by weight. ru.

[0085]

[0069] The disinfectant product may also contain a pH adjuster. A suitable pH adjuster is sodium hydroxide This invention includes lium, sodium citrate and other similar compounds. The final disinfectant composition has a pH in the range of approximately 6 to approximately 13. Generally, disinfectant compositions have a pH of p When H is in the range of approximately 6 to approximately 8, it is considered a neutral disinfectant composition. The disinfectant composition is A pH range of approximately 8 to 12 is considered an alkaline disinfectant composition. ru.

[0086]

[0070] The disinfectant composition optionally contains a corrosion inhibitor, a complexing agent, an auxiliary agent, a preservative, a fragrance, It may further contain colorants and the like. Exemplary corrosion inhibitors include, for example, organophosphorus compounds and It contains a blend of organophosphorus compounds and polymer components. An example of an auxiliary agent is, for example, polyethylene. Contains lenglycol or other similar compounds. Colorants and fragrances enhance the function of the composition. It may be added, provided that it does not interfere and can help identify the composition. Generally, Any additional optional ingredients constitute less than approximately 20% by weight of the composition.

[0087]

[0071] The disinfectant composition may also contain at least one acid or a salt thereof. The acid is inorganic It may be an acid or an organic acid. In preferred embodiments, the acid is a C1-C8 carboxylic acid. Yes. In certain embodiments, the acid is a monocarboxylic acid, dicarboxylic acid, tricarboxylic acid, and or a mixture of these. In additional embodiments, the acid is a hydroxyl acid, an aromatic acid, Or a mixture thereof. In another additional embodiment, the acid is methanesulfonic acid, ri Phytic acid, etidronic acid, phytic acid, phosphoacetic acid, N-(phosphonomethyl)iminodiacetic acid, Diethylenetriaminepentakis(methylphosphonic acid), S,S-ethylenediamine-N 'N'-Disuccinic acid, their alkali salts, or any mixture thereof.

[0088]

[0072] In some embodiments, the acid is citric acid, phosphoric acid, succinic acid, lactic acid, S,S-ethic acid Didiamine-N,N'-Nisuccinic Acid, 1-Hydroxyethane 1,1-Diphosphonic Acid (H EDP, dipicolinic acid (DPA), methanesulfonic acid (MSA), and their alkali salts , or any mixture thereof.

[0089]

[0073] In one embodiment, the acid is a mixture of acids. In some embodiments, the acid is one or several of the following organic acids: citric acid, succinic acid, phosphoric acid, and lactic acid. Another implementation form In this state, the acid is one or fewer acids: citric acid, succinic acid, phosphoric acid, and lactic acid. , and in combination with other acids. For example, citric acid contains ethylenediamine-N,N'-nico Used in combination with sic acid or its alkali salts, HEDP, and / or MSA. It is possible. As another example, succinic acid is ethylenediamine-N,N'-disuccinic acid or It can be used in combination with its alkali salt, HEDP, and / or MSA. Another example Phosphoric acid is ethylenediamine-N,N'-disuccinic acid or its alkali salt. It can be used in combination with HEDP and / or MSA. As another example, lactate is Ethylenediamine-N,N'-disuccinic acid or its alkali salts, HEDP, and / Alternatively, it can be used in combination with MSA.

[0090]

[0074] The disinfectant composition contains about 1% to about 5% by weight of an organic acid, such as citric acid or succinic acid. , phosphoric acid, lactic acid, or mixtures thereof, may be included in combination with another acid. In another aspect , the composition comprises from about 1% by weight to about 5% by weight of an organic acid, such as citric acid, succinic acid, phosphori c acid, lactic acid, or mixtures thereof, in combination with from about 0.05% by weight to about 5% by weight of another acid and may be included in combination. In another embodiment, the composition comprises from about 2% by weight to about 4% by weight of an organic acid , such as citric acid, succinic acid, phosphoric acid, lactic acid, or mixtures thereof, in an amount of about 0.1% by weigh t% to about 4% by weight of another acid, for example ethylenediamine-N,N'-disuccinic acid or a salt thereof alkali salts thereof, HEDP, and / or MSA, etc., in combination.

[0091] Use of disinfectant A variety of different disinfectant compositions can be manufactured according to the present disclosure. Disinfectant products can , for example, for cleaning hard surfaces, for pre-cleaning sterilization or high-level disinfection of instruments , and / or can be used as a hand sanitizer. In general, a biocide can be incorporated into any suitable disinfec tant product.

[0092] When used as a hard surface cleaner, the disinfectant composition can be delivered by conventional means to the surface to be clea ned, sanitized or disinfected, for example, by pouring the composition onto the surface ; spraying; spraying is applied to the surface via spraying means including but not limited to pump spray app licators, pressurized spray applicators, etc.; a fully saturated wipe; cloth and bucket; mop and bucket; sponge and bucket; or automatic cleani ng equipment and other similar conventional methods, for the purpose of sanitizing or disinfecting a surface, an antibac terial composition is applied to the surface.

[0093]

[0078] To use the disinfectant composition of this disclosure, spray the antimicrobial composition onto a surface, note The surface is treated with the substrate by wiping, or by other applications. When applied to a surface, the antibacterial composition can remain on the surface for a certain period of time. The composition can be applied to a surface and dried, or alternatively, the surface can be dried by wiping or It may be dried by wiping with a wiping device.

[0094]

[0079] Surfaces that can be disinfected with this composition include dairy factories, homes, healthcare facilities, swimming pools, etc. This includes oil, canning plants, food processing plant facilities, restaurants, hospitals, facilities, and secondary oil recovery. This includes, but is not limited to, those located in the glass and polished aluminum industries. Hard surfaces such as those mentioned above are particularly suitable for application. Specific areas where application is targeted include kitchen cooking. Countertops, cabinets, electrical appliances, waste containers, laundry room, trash cans, bathroom fixtures, toilets, aquariums, faucets, mirrors This includes hard surfaces in homes such as vanity units, bathtubs, and showers. This composition also includes, Floors, walls, furniture, mirrors, toilet fixtures, windows, and wood surfaces, such as fence boards, patio railings, It can be used to disinfect terraces, roofs, siding, window frames, and door frames. Substances, quaternary ammonium chloride compounds, and disinfectant active substances are used on cutting boards, kitchen utensils, It is particularly suitable for application to surfaces that come into indirect contact with food, such as containers, dishes, sinks, electrical appliances, and countertops. Suitable for: This composition or quaternary ammonium chloride compounds are suitable for dairy farm equipment, milking It can be used to disinfect milking machines, milk pails, tank trucks, etc. In the hospital area, Head, stretcher with cart, table, canister, toilet, waste can, stand, cupboard, This includes shower rooms, floors, walls, or any other non-porous surfaces.

[0095]

[0080] One particularly useful application method is to impregnate the wipe substrate with a disinfectant composition. Yes. In this embodiment, the wipe is a single-use wipe impregnated with a disinfectant composition. The wipes are stored in a container from which the user can separate and remove them. The container containing the wipes is a single container. It may contain one or more wipes. A suitable container is one that can be opened by the user. Includes a pouch containing a single wipe such as a towel, or a resealable opening. It may be a pouch having a feature that allows a single wipe to be taken out of the opening at once. It contains several wipes in stackable, rolled, or other suitable forms to enable stacking. Pouches are generally made of liquid-impermeable materials such as film, coated paper, or foil. Alternatively, it may be made from other similar liquid-impermeable materials. Another method for separating and removing the wipes of the present invention The method involves placing the wipes in a liquid-impermeable container that has an opening that allows the wipes inside to be reached. The container is a molded plastic container with a liquid-impermeable lid. It is also acceptable. Generally, the lid has an opening that allows access to the wipes inside the container. The wipes are designed so that when one wipe is removed from the container, the user can take out the next wipe. They may be prepared and stacked alternately so that the next wipe is positioned at the opening of the container. Alternatively, the wipes are perforated between individual wipes of the continuous material, It may be a material. A continuous wipe material having perforations is in a folded form. It may also be in roll form. Generally, in roll form, the wipe material is The material is supplied from the center of the roll. Because they are stacked alternately, one wipe is When removed from the container, the next wipe is for use to retrieve the next wipe when necessary is positioned at the opening.

[0096]

[0081] Disposable wipes offer advantages over other application media such as reusable sponges and rugs . Unlike repeatedly used sponges, rugs and the like, impregnated wipes are used once before being used and disposed of. As mentioned above, reused sponges or rugs can cause problems because sponges or rugs can carry microorganisms that are not easily killed by the disinfectant composition . Furthermore, the disinfectant composition is formulated to treat hard surfaces, and is not formulated to treat porous soft surfaces present on sponges or rugs.

[0097]

[0082] Wipes can be pre-moistened, and the wipe can be impregnated with a disinfectant composition such that the disinfectant composition emerges or is released onto the surface when the wipe moves across the surface to be treated. In general, during a wiping operation, the disinfectant composition is sufficiently impregnated into the wipe so that the wipe releases the disinfectant composition onto the surface.

[0098]

[0083] Depending on the wipe substrate, generally, about 3 parts by weight of the used disinfectant composition per 1 part by weight of wipe substrate is used for sufficient impregnation. Generally, the disinfectant composition is used in an amount of about 4 to 6 parts by weight per 1 part by weight of wipe substrate. Within these ranges , the substrate can be completely and sufficiently impregnated. Depending on the specific wipe substrate, the amount of disinfectant solution may be increased or decreased in order to achieve complete and sufficient impregnation of the wipe substrate. It should be noted that

[0099]

[0084] Suitable wipe substrates include woven materials and nonwoven materials. Essentially, any nonwoven wipe Blowing materials may be used. Exemplary nonwoven materials include molten blow, corformed, and spunbon. D, airlaid, water-entangled nonwoven fabric, spunlace, bonded carded web, and These laminates may include, but are not limited to, these. Optionally, nonwoven fabrics may also be used. It may be laminated with film material. The fibers used to make the wipe substrate are cellulose The fibers may be thermoplastic fibers, thermoplastic fibers, or mixtures thereof. The fibers may also be continuous fibers. It may also be discontinuous fibers, short fibers, or mixtures thereof. The basis weight of the nonwoven web is 1 square meter It can vary from approximately 12 grams per square meter to over 200 grams per square meter.

[0100]

[0085] In one embodiment, the wipe contains both the active and inactive components at an acceptable tolerance level. The disinfectant composition, impregnated with the liquid component contained within, emerges from the wipe and allows the active ingredient to be absorbed. It contains within a resistance level. Once applied to a surface, the antimicrobial disinfectant composition will last for a certain period of time. The antimicrobial composition can be applied to a surface and dried. Alternatively, wipe the surface with a dry wipe or, preferably, an unused wiping tool. It may dry out as a result.

[0101]

[0086] When the wipe or disinfectant composition of the present invention is used to wipe a surface, The poison is achieved in less than 4 minutes, generally within 3 minutes, and especially within 90 seconds. Antimicrobial disinfectant compositions, It is important to remain in contact with the surface requiring disinfection for a sufficient amount of time for the disinfection to take place. This will be understood by the industry. The composition of the present invention is effective against many different microorganisms, including but not limited to. It was found to be effective.

[0102]

[0087] In yet another embodiment, the disinfectant composition may be used as a hand sanitizer. When used as a disinfectant, the biocide formulation of this disclosure may be combined with any of the above-mentioned ingredients. It can be combined. In one embodiment, for example, the biocide is water and / or alcohol. It can be combined with any solvent. In one particular application, it is dispensed from the dispenser. If so, a foaming agent may be added to the composition to cause foaming. The foaming agent is biocidal. It may contain any suitable foaming agent that is compatible with the agent. In one embodiment, for example, the foaming agent is for hands It may contain dimethicone or other similar agents that can cause the disinfectant to foam.

[0103]

[0088] In one embodiment, the disinfectant composition is for pre-cleaning and disinfection, or for use on terminals, etc. It can be used for disinfecting instruments, equipment, medical instruments, or endoscopes at a high level. In one embodiment, When the instruments are handled manually, the disinfectant composition will be used to disinfect the instruments with an appropriate concentration of the disinfectant composition. It can be applied by immersion. For example, as a container for the disinfectant composition, plastic A sack or metal container, a stainless steel sink, or any other suitable container may be used. In one embodiment, the complete instrument or device or endoscope includes gaps, holes, and hollow portions. Complete immersion may be required. When used for disinfecting instruments such as endoscopes, endoscopes and other The channels of the instrument may need to be rinsed. Generally, after disinfection, the instrument should be rinsed with water. It must be rinsed thoroughly with plenty of water until it is completely washed away.

[0104]

[0089] For applications involving instruments, the appropriate concentration of the disinfectant composition is approximately 500 mg / L to approximately 25 It can range from approximately 1,000 mg / L to approximately 23,000 mg / L, for example. For pre-cleaning, the preferred concentration of the disinfectant composition is approximately 500 mg / L to approximately 10,000 mg. / L, for example, approximately 1,000 mg / L to approximately 9,000 mg / L, or approximately 2,000 mg / L ~8,000 mg / L, etc., approximately 3,000 mg / L~7,000 mg / L, etc., approximately 4 It can range from 1,000 mg / L to approximately 6,000 mg / L. For high-level disinfection, disinfectant mixtures are used. The preferred concentration of the product is approximately 5,000 mg / L to approximately 25,000 mg / L, for example, approximately 8. For example, 000 to approximately 23,000 mg / L, or approximately 10,000 to approximately 20,000 mg / L. It is possible. In embodiments where the instrument is immersed in the disinfectant composition, the required contact time is approximately 10 minutes. The required contact time may be in the range of approximately 60 minutes, preferably approximately 15 minutes to approximately 30 minutes. It can be adjusted based on the resulting disinfection level. In yet another embodiment, the disinfectant composition is It can be used for disinfecting instruments in automatic cleaning and disinfecting machines.

[0105]

[0090] Various different microorganisms can be killed or controlled by the present disclosure. For example, The disclosed disinfectant composition can control Gram-positive bacteria, Gram-negative bacteria, and the like. In addition, the disinfectant compositions of this disclosure also contain viruses, spores, mycobacteria, and other similar substances. It can kill various other microorganisms and control their growth. Examples of specific microorganisms that can be controlled include Staphylococcus aureus, S. treptococcus pneumoniae, Pseudomonas aeru ginosa, Serratia marcescens, Salmonella en teritidis, Neisseria gonorrhoeae, Escheric hia coli, Enterococcus hirae, Acinetobacte r baumannii, Listeria monocytogenes, Enter obacter gergoviae, Klebsiella pneumoniae, Burholderia cepacia, Pseudomonas putida, K ocuria rhizophila, Candida albicans, Sacch aromyces cerevisiae, Aspergillus brasilie nsis, Penicillium funiculosum, Eupenicilli um levitum, Bacillus cereus, Bacillus subt ilis, Clostridium difficile, Clostridium p erfringens, Mycobacterium tuberculosis, My cobacterium terrae, Mycobacterium avium, P oliovirus, Adenovirus, Norovirus, Vaccinia virus, influenza virus, Hepatitis B virus, Human n Immunodeficiency virus, human papillomavirus, or This mixture contains these ingredients. [Examples]

[0106]

[0092] In order to demonstrate the synergistic effect, the following examples were carried out.

[0107]

[0093] Preparation of test organisms

[0094] The target organism is Pseudomonas aeruginosa ATCC Remove 15442 from the freezer and leave on Tryptone Soy Agar (TSA) at 37°C for 24 hours. The culture was grown in between. A second subculture was generated from the first and grown under the same conditions. Next, the loop A test suspension is prepared by adding one scoop of the organism to tryptone-buffered saline, and the internal components are checked. Using a calibrated spectrophotometer at a wavelength of 600 nm, the cell concentration was measured at 1 × 10⁻⁶ 8 and 5 ×10 8 It was adjusted to CFU / ml. To establish the exact CFU / ml, then 1 ml was added. Remove the aliquots from the test suspension and 10 -6 and 10 -7 Dilute continuously, then 1 m Each dilution of l was repeated in TSA using the pour plate method. The plates were then plated. Next, the plates were incubated at 37°C for 24 hours and counted.

[0108]

[0095] Preparation of test samples

[0096] For each biocide formulation to be tested, a series of three samples were prepared in sterile distilled water;

[0097] Test sample 1 - Biocide alone (to measure the basic efficacy of the biocide)

[0098] Test sample 2-Caprylic acid / caprate polyglyceryl-10 combined with animal killing Physical formulations (to measure the efficacy of combinations of biocides and polyglycerol esters)

[0099] Control - A control sample of caprylic / capric acid polyglyceryl-10 was prepared in deionized water. The preparations were made in the environment, and the efficacy of the polyglycerol ester alone was measured.

[0109]

[0100] Considering the dilution effect from the addition of the test organism suspension during the test procedure, each test sample The solution was prepared at a concentration 10% higher than the target concentration.

[0110]

[0101] Test Procedure

[0102] Place a 0.1 ml aliquot of the test organism suspension into a tube, followed by 0.9 ml The test mixture was prepared by adding the test sample (prepared as described above). Next, this set The mixture was mixed, and the timer was started immediately. Each test mixture was subjected to the specified contact time shown in Table 1. It was left to stand.

[0111]

[0103]

[0112] [Table 1]

[0113]

[0104] When the specified contact time is reached, 0.1 ml aliquots of the test mixture are added to 0.9 ml The test mixture was deactivated by adding it to the neutralized culture medium and mixing the entire solution. The solution was left to stand for 5 minutes to confirm that the biocide's effects had been effectively neutralized.

[0114]

[0105] To quantify the number of remaining organisms in the neutralized test mixture, 4 × 0.025 Take out ml of aliquots and spot plate them onto the surface of dry TSA. Next, The plates were incubated at 37°C for 24 hours.

[0115]

[0106] Counting and calculation of logarithmic decrease

[0107] Limit of Detection (LOD)

[0108] Depending on the dilution parameters of the methods and techniques used to count cells, To ensure reliable counts, specific detection limits must be established.

[0116]

[0109] Regarding the count of pour plates, the lower limit of the count is <10 and the lower limit is >330. The colonies from the incubated plates were counted using a colony limit. For example, If a plate has 7 visible colonies that can be counted, then <10 is recorded. 10 is used in the calculation. Regarding the upper limit, 407 colonies are counted on the plate. If this occurs, >330 will be recorded, and 330 will be used in the calculation.

[0117]

[0110] Regarding spot plating, the count limit is <1 and the count limit is >150. We used a limit to count the colonies from the incubated plates. For example, If the rate has 0 visible colonies, <1 is recorded and 1 is used for calculation. Regarding the upper limit, if 156 colonies are counted on the plate, >150 will be recorded. It is recorded, and 150 is used in the calculation.

[0118]

[0111] When reporting the final logarithmic decline, use a lower detection limit for calculation. In this case, a value of ">", for example, ">5.02 logarithmic decrease", is reported, while to calculate more When high detection limits are used, "<" values, such as "<2.92 logarithmic decrease", are reported.

[0119]

[0112] Counting and calculation of N (test organism suspension) and N0

[0120]

number

[0121] During the ceremony, C is the sum of the survival count values, n1 is a lower dilution, i.e., 10 -6 This is the number of survival count values ​​related to, n2 is a higher dilution, i.e., 10 -7 This is the number of survival count values ​​related to, 10 -6 This is the dilution ratio corresponding to a lower dilution, for example:

[0122]

number

[0123] N0 is the number of cells per 1 ml of the test mixture at the start of the contact time. This is due to a 10-fold dilution caused by the addition of the test product, resulting in a weighted average of N that is one-tenth of the original value. Therefore, in this example, N0 is 1.9 × 10 7 The concentration is cfu / ml.

[0124]

[0113] Counting and calculation of T (test mixture) First, use the following calculation to determine the average CFU per 0.025 ml spot (me The average was determined;

[0125]

number

[0126] During the ceremony, d1 is the sum of the survival count values ​​from the 4 spots. example:

[0127]

number

[0128] Next, this was multiplied by 40 to determine the cfu / ml; example; T = 29.5 × 40 = 1180 cfu / ml During the neutralization step, the test mixture underwent a 10-fold dilution. Taking this into consideration, the final result was 10 Apply multiplication by a factor of two; T = 1180 × 10 = 11800 = 1.18 × 104 cfu / ml Calculation of logarithmic decrease (N0-T) Before calculating the logarithmic decrease, both N0 and T were converted to logarithmic values ​​of base 10. For example; N0 = 1.9 × 10 7 =7.28log10 T = 1.18 × 10 4 =4.07log10 The following formula was used to calculate the final logarithmic decrease; N0-T = Logarithmic decrease for example; 7.28 - 4.07 = 3.21 The final logarithmic decrease for this example is 3.21.

[0129]

[0114] Example 1

[0115] Using the test procedure outlined above, Caprylic / Capric Polyglyceryl-1 The synergistic effects between 0 (PG10CC) and the various biocides listed in Table 1 were tested. Caprylic / Capric Polyglyceryl Glyceryl-10 is reported in Table 2 below. As shown above, at 100 ppm, it showed little to no activity. Prepare the substance and, regarding the presence of Pseudomonas aeruginosa, in 5 minutes The tests were conducted. Table 2 below shows the initial signs of synergistic effects between the biocide and PG10CC. The amounts of biocidal raw materials and PG10CC were present. The calculated logarithmic decrease is Pseud This is for Omonas aeruginosa, and the table shows various mixtures. As shown in 2.

[0130]

[0116]

[0131] [Table 2]

[0132]

[0117] The present invention is described above with reference to specific embodiments thereof, but is not disclosed herein. It is clear that many changes, modifications, and variations can be made without deviating from the inventive concept. Therefore, all claims are within the spirit and broad scope of the attached claims. It is intended to include such changes, modifications, and variations.

Claims

1. A disinfectant composition, (i) biocides; and (ii) Contains polyglycerol esters, The polyglycerol ester enhances the efficacy of the biocide compared to the biocide alone. It is present in an amount that is sufficient to increase, and that increase is greater than that of the biocide used alone. The additive effect of the biocide activity of polyglycerol esters is greater than that of polyglycerol esters. Disinfectant composition.

2. The weight ratio of the polyglycerol ester to the biocide is 0.00001 to 10. A range of 0, for example, a range of 0.0001 to 2.0, for example, a range of 0.001 to 1.5, for example The disinfectant composition according to claim 1, wherein the concentration is in the range of 0.01 to 1.

0.

3. The biocides include quaternary ammonium compounds, tertiary amines, guanides, and biguanides. Alcohols, phenolic compounds, organic acids, peroxides, peracids, iron chelating agents, pyridine compounds The disinfectant composition according to claim 1, comprising a substance, an iodine compound, or a mixture thereof.

4. The aforementioned tertiary amine is N,N-bis(3-aminopropyl)dodecyl-1,3propane (C) ８ ~C １６ ) A disinfectant mixture according to claim 3, comprising an alkyl tertiary amine. Finished product.

5. The biocide is an alkyl quaternary ammonium compound, benzyl quaternary ammonium compound. Claims including quaternary ammonium compounds such as compounds or di-quaternary ammonium compounds. The disinfectant composition described in item 3.

6. The alkylquaternary ammonium compound is diC ８～１８ Alkyldimethylammonium Mu compound or benzyl C ８～１８ Claim comprising an alkyldimethylammonium compound The disinfectant composition described in 5.

7. The aforementioned di-quaternary ammonium compound is bis(2-N,N-dimethyl-N-alkyla The disinfectant composition according to claim 5, comprising a monium ethyl ether compound.

8. The quaternary ammonium compound has a salt anion, and the anion is a halogen Ions, carbonate ions, bicarbonate / carbonate ions, carboxylate ions, sulfonate ions or The disinfectant composition according to claim 5, comprising phosphate ions.

9. The disinfectant composition according to claim 3, wherein the biocide comprises a guanide such as a biguanide.

10. The guanide is polyhexamethylene monoguanide, polyhexamethylene biguanide, etc. The disinfectant composition according to claim 9, comprising chlorhexidine.

11. The disinfectant composition according to claim 3, wherein the biocide comprises an acid.

12. The biocide is para-chlorometaxylenol, 2-pyridinol-1-oxide ( A disinfectant mixture according to claim 3, comprising HPNO), octenidine, or povidone-iodine. Finished product.

13. The polyglycerol ester has (a) 2 to 12 glycerol components based on the average value. (b) polyglycerol components composed of the following, and (b) caprylic acid, capric acid, lauric acid Myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignosinate A phosphate derived from fatty acids containing phosphate, cerotic acid, oleic acid, or decaoleic acid A disinfectant composition according to any one of claims 1 to 12, comprising a ligcerol ester. 。

14. The polyglyceryl fatty acid esters include one or more polyglyceryl laurates.

10. Polyglyceryl-10 decaoleate; Polyglyceryl-3 monostearate; Di Polyglyceryl-6 stearate, polyglyceryl-10 stearate; polyglyceryl oleate Glyceryl-10; Polyglyceryl-10 dipalmitate, or Caprylic / Capric Acid The disinfectant composition according to claim 13, comprising polyglyceryl-10 acid.

15. A method for increasing the potency of a biocide in a disinfectant solution, comprising the step of preparing the biocide. The process includes the step of adding an effective amount of polyglycerol ester to the biocide, Compared to an equivalent amount of a biocide without the polyglycerol ester, the efficacy of the biocide A way to increase it.

16. Cleaners for hard surfaces, disinfectants for hands and skin, cleaners for hands and skin, for instruments Pre-disinfectant cleaners, sterilizing and high-level disinfectant compositions, or disinfectants for soft surfaces, For example, laundry detergent or cleaning agent for fabrics and interior decorations, any of claims 1 to 14 Final-use formulation containing any of the biocides listed in item 1.

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