Microbial control agents

Abstract

The present invention provides a microbial control agent that can solubilize 2-n-octyl-4-isothiazolin-3-one. [Solution] The microbial control agent of this disclosure contains a microbial control component and an aminoacetic acid betaine-type amphoteric surfactant, wherein the microbial control component contains 2-n-octyl-4-isothiazolin-3-one.

Description

[Technical Field]

[0001] The present disclosure relates to a microbial control agent. More specifically, it relates to a microbial control agent used as a control agent against bacteria, molds, yeasts, algae and the like. [Background Art]

[0002] Conventionally, harmful microorganisms such as bacteria, molds, yeasts, and algae are prone to propagate in various industrial products, causing problems such as decreased productivity, reduced quality, and generation of foul odors. Therefore, in order to control the propagation of such harmful microorganisms, it is widely known that various microbial control agents that exert effects such as antibacterial activity, mildew resistance, antisepsis, and algae resistance are added to industrial products.

[0003] As an active ingredient (microbicidal ingredient) of such microbial control agents, 2-n-octyl-4-isothiazolin-3-one is known. Since 2-n-octyl-4-isothiazolin-3-one is hydrophobic, it separates from water in microbial control agents. Therefore, studies have been conducted to add a nonionic surfactant to a microbial control agent containing 2-n-octyl-4-isothiazolin-3-one to solubilize 2-n-octyl-4-isothiazolin-3-one (see, for example, Patent Document 1). [Prior Art Documents] [Patent Documents]

[0004] [Patent Document 1] Japanese Unexamined Patent Publication No. 2005-68054 [Summary of the Invention] [Problem to be Solved by the Invention]

[0005] However, depending on the formulation of the microbial control agent, the nonionic surfactant described in Patent Document 1 may not be able to sufficiently solubilize 2-n-octyl-4-isothiazolin-3-one in some cases.

[0006] This disclosure provides a microbial control agent capable of solubilizing 2-n-octyl-4-isothiazolin-3-one.

[0007] Furthermore, the ability to solubilize 2-n-octyl-4-isothiazolin-3-one indicates that 2-n-octyl-4-isothiazolin-3-one is in a miscible state within the microbial control agent. Specifically, as described in the examples, this indicates that the microbial control agent containing 2-n-octyl-4-isothiazolin-3-one is transparent. [Means for solving the problem]

[0008] This disclosure [1] includes a microbial control agent comprising a microbial control component and an aminoacetic acid betaine-type amphoteric surfactant, wherein the microbial control component comprises 2-n-octyl-4-isothiazolin-3-one.

[0009] This disclosure [2] includes the microbial control agent described in [1] above, wherein the mass ratio of the aminoacetic acid betaine-type amphoteric surfactant to the 2-n-octyl-4-isothiazolin-3-one is 0.20 or more.

[0010] The present disclosure [3] includes the microbial control agent described in [1] or [2] above, wherein the mass ratio of the aminoacetic acid betaine-type amphoteric surfactant to the 2-n-octyl-4-isothiazolin-3-one is 4.5 or less.

[0011] This disclosure [4] includes a microbial control agent according to any one of the above [1] to [3], wherein the content of the aminoacetic acid betaine type amphoteric surfactant in the microbial control agent is 0.25% by mass or more.

[0012] This disclosure [5] includes a microbial control agent according to any one of the above [1] to [4], wherein the content of the aminoacetic acid betaine type amphoteric surfactant in the microbial control agent is 5.0% by mass or less.

[0013] This disclosure [6] includes a microbial control agent according to any one of the above [1] to [5], wherein the content of 2-n-octyl-4-isothiazolin-3-one in the microbial control component is 10.0% by mass or more.

[0014] This disclosure [7] includes a microbial control agent according to any one of the above [1] to [6], wherein the content of 2-n-octyl-4-isothiazolin-3-one in the microbial control agent is 0.1% by mass or more.

[0015] This disclosure [8] includes a microbial control agent according to any one of the above [1] to [7], wherein the microbial control component further comprises a hydrophilic microbial control component.

[0016] This disclosure [9] includes a microbial control agent according to any one of the above [1] to [8], further containing a stabilizer. [Effects of the Invention]

[0017] The microbial control agent of this disclosure contains a microbial control component and an aminoacetic acid betaine-type amphoteric surfactant, wherein the microbial control component contains 2-n-octyl-4-isothiazolin-3-one. Therefore, 2-n-octyl-4-isothiazolin-3-one can be solubilized. [Modes for carrying out the invention]

[0018] The microbial control agent of this disclosure contains a microbial control component and an aminoacetic acid betaine-type amphoteric surfactant. More specifically, the microbial control agent contains a microbial control component, an aminoacetic acid betaine-type amphoteric surfactant, and a solvent. The microbial control agent may further contain a stabilizer as needed. Furthermore, the microbial control agent may contain other additives as needed.

[0019] 1. Microbial control ingredients The microbial control ingredient is an active ingredient of a microbial control agent. The microbial control ingredient comprises 2-n-octyl-4-isothiazolin-3-one (hereinafter sometimes referred to as OIT). Preferably, the microbial control ingredient further includes a hydrophilic microbial control ingredient.

[0020] OIT is a hydrophobic microbial control ingredient. The hydrophobic microbial control ingredient refers to a substance whose solubility in 100 g of water is less than 0.5 g under a room temperature (15°C to 30°C) environment. Under a room temperature (15°C to 30°C) environment, the solubility of OIT in 100 g of water is, for example, less than 0.1 g.

[0021] The content ratio of OIT in the microbial control ingredient is, for example, 5.0% by mass to 80.0% by mass, preferably 8.0% by mass to 60.0% by mass, more preferably 10.0% by mass to 50.0% by mass, still more preferably 12% by mass to 40.0% by mass, and particularly preferably 15.0% by mass to 30.0% by mass.

[0022] The content ratio of OIT in the microbial control ingredient is, for example, 5.0% by mass or more, preferably 8.0% by mass or more, more preferably 10.0% by mass or more, still more preferably 12.0% by mass or more, and particularly preferably 15.0% by mass or more.

[0023] When the content ratio of OIT in the microbial control ingredient is equal to or higher than the above lower limit, microorganisms can be controlled more reliably. Although details will be described later, since the microbial control agent contains an aminoacetic acid betaine-type amphoteric surfactant, OIT can be solubilized in water even when the content ratio of OIT in the microbial control ingredient is equal to or higher than the above lower limit.

[0024] The microbial control ingredient may consist of OIT. When the microbial control ingredient consists of OIT, the content ratio of OIT in the microbial control ingredient is 100% by mass.

[0025] If the microbial control component includes microbial control components other than OIT (for example, hydrophilic microbial control components described later), the content of OIT in the microbial control component is, for example, 80.0% by mass or less, preferably 60.0% by mass or less, more preferably 50.0% by mass or less, even more preferably 40.0% by mass or less, and particularly preferably 30.0% by mass or less.

[0026] The amount of OIT blended with 100 parts by mass of solvent is, for example, 0.05 parts by mass or more, preferably 0.20 parts by mass or more, more preferably 0.40 parts by mass or more, and for example, 30 parts by mass or less, preferably 20 parts by mass or less, more preferably 15 parts by mass or less, even more preferably 10 parts by mass or less, and particularly preferably 8 parts by mass or less.

[0027] The amount of OIT blended with 100 parts by mass of water in the solvent is, for example, 0.1 to 40 parts by mass, preferably 0.3 to 30 parts by mass, more preferably 0.5 to 25 parts by mass, even more preferably 0.5 to 20 parts by mass, particularly preferably 0.5 to 15 parts by mass, and most preferably 0.5 to 10 parts by mass.

[0028] The amount of OIT blended with 100 parts by mass of water in the solvent is, for example, 0.1 parts by mass or more, preferably 0.3 parts by mass or more, more preferably 0.5 parts by mass or more, and for example, 40 parts by mass or less, preferably 30 parts by mass or less, more preferably 25 parts by mass or less, even more preferably 20 parts by mass or less, particularly preferably 15 parts by mass or less, and most preferably 10 parts by mass or less.

[0029] If the amount of OIT blended with 100 parts by mass of water in the solvent is less than or equal to the above upper limit, OIT can be more reliably solubilized in water.

[0030] The OIT content in the microbial control agent is, for example, 0.1% to 20.0% by mass, preferably 0.3% to 15.0% by mass, more preferably 0.5% to 10.0% by mass, even more preferably 0.5% to 8.0% by mass, and most preferably 0.5% to 5.0% by mass.

[0031] The content of OIT in the microbial control agent is, for example, 0.1% by mass or more, preferably 0.3% by mass or more, more preferably 0.5% by mass or more, and also, for example, 20.0% by mass or less, preferably 15.0% by mass or less, more preferably 10.0% by mass or less, even more preferably 8.0% by mass or less, and particularly preferably 5.0% by mass or less.

[0032] If the OIT content in a microbial control agent is above the lower limit mentioned above, microorganisms can be controlled more reliably. Furthermore, if the OIT content in a microbial control agent is below the upper limit mentioned above, OIT can be solubilized more reliably.

[0033] Hydrophilic microbial control components refer to substances whose solubility in 100g of water at room temperature (15°C to 30°C) is 0.5g or more.

[0034] Under room temperature conditions (15°C to 30°C), the solubility of the hydrophilic microbial control component in 100g of water is preferably 1.0g or more, more preferably 2.0g or more, and even more preferably 3.0g or more.

[0035] Examples of hydrophilic microbial control components include those from the group consisting of organic iodine compounds, triazole compounds, carbamoylimidazole compounds, dithiol compounds, isothiazolinone compounds, nitro alcohol compounds, parahydroxybenzoic acid esters, benzimidazole compounds, triazine compounds, pyrithione compounds, and bisquaternary ammonium compounds, which have a solubility of 0.5 g or more per 100 g of water at room temperature (15°C to 30°C).

[0036] Preferred hydrophilic microbial control components include organic iodine compounds, isothiazolinoline compounds, nitroalcohol compounds, pyrithione compounds, and bisquaternary ammonium compounds. More preferably, iodoacetamide, 2-methyl-4-isothiazolin-3-one, 2-bromo-2-nitro-1,3-propanediol, sodium pyrithione, and N,N'-hexamethylenebis(4-carbamoyl-1-decylpyridinium acetate).

[0037] The content ratio of hydrophilic microbial control components in the microbial control components is, for example, 20% by mass or more, preferably 40% by mass or more, more preferably 50% by mass or more, even more preferably 60% by mass or more, particularly preferably 70% by mass or more, and also, for example, 95% by mass or less, preferably 92% by mass or less, more preferably 90% by mass or less, even more preferably 88% by mass or less, particularly preferably 85% by mass or less.

[0038] If the microbial control component includes a hydrophilic microbial control component, microorganisms can be controlled more reliably while ensuring compatibility between OIT and water. In particular, the above effect can be achieved if the proportion of the hydrophilic microbial control component in the microbial control component is within the above range.

[0039] The amount of hydrophilic microbial control component blended with 100 parts by mass of solvent is, for example, 0.05 parts by mass or more, preferably 0.20 parts by mass or more, more preferably 0.40 parts by mass or more, and also, for example, 80 parts by mass or less, preferably 60 parts by mass or less, more preferably 40 parts by mass or less, even more preferably 20 parts by mass or less, and particularly preferably 10 parts by mass or less.

[0040] The amount of hydrophilic microbial control component blended with 100 parts by mass of water in the solvent is, for example, 0.1 parts by mass or more, preferably 0.3 parts by mass or more, more preferably 0.5 parts by mass or more, and also, for example, 100 parts by mass or less, preferably 80 parts by mass or less, more preferably 60 parts by mass or less, even more preferably 40 parts by mass or less, and particularly preferably 20 parts by mass or less.

[0041] The content ratio of hydrophilic microbial control components in the microbial control agent is, for example, 0.1% by mass or more, preferably 0.3% by mass or more, more preferably 0.5% by mass or more, and also, for example, 30% by mass or less, preferably 20% by mass or less, more preferably 10% by mass or less.

[0042] The microbial control component may include other hydrophobic microbial control components besides OIT, if necessary. As stated above, a hydrophobic microbial control component refers to a component whose solubility in 100g of water is less than 0.5g at room temperature (15°C to 30°C).

[0043] Examples of hydrophobic microbial control components other than OIT include organic iodine compounds, triazole compounds, carbamoylimidazole compounds, dithiol compounds, isothiazolinone compounds (excluding OIT), nitro alcohol compounds, parahydroxybenzoic acid esters, benzimidazole compounds, triazine compounds, pyrithione compounds, and bisquaternary ammonium compounds, which have a solubility of less than 0.5 g per 100 g of water at room temperature (15°C to 30°C).

[0044] Other hydrophobic microbial control components besides OIT are preferably organic iodine compounds, triazole compounds, isothiazolin compounds (excluding OIT), nitro alcohol compounds, benzimidazole compounds, pyrithione compounds, and bisquaternary ammonium compounds. More preferably, these include 3-iodo-2-propynyl=N-butylcarbamate, tebuconazole, 1,2-benzoisothiazole-3(2H)-one, 2,2-dibromo-2-nitroethanol, carbendazim, zinc pyrithione, and N,N'-hexamethylenebis(4-carbamoyl-1-decylpyridinium bromide).

[0045] The content of other hydrophobic microbial control components other than OIT in the microbial control component is, for example, 30% by mass or less, preferably 20% by mass or less, more preferably 10% by mass or less, even more preferably 5.0% by mass or less, particularly preferably 1% by mass or less, and most preferably 0% by mass. In other words, the microbial control component preferably does not contain other hydrophobic microbial control components other than OIT.

[0046] 2. Aminoacetic acid betaine type amphoteric surfactant Aminoacetic acid betaine-type amphoteric surfactants are a type of amphoteric surfactant. Aminoacetic acid betaine-type amphoteric surfactants improve the compatibility of water and OIT in a solvent. In other words, aminoacetic acid betaine-type amphoteric surfactants solubilize OIT in microbial control agents.

[0047] Examples of aminoacetic acid betaine-type amphoteric surfactants include alkyldimethylaminoacetic acid betaine, alkyldiethylaminoacetic acid betaine, alkyldipropylaminoacetic acid betaine, alkylamidopropyldimethylaminoacetic acid betaine, alkyldihydroxymethylaminoacetic acid betaine, and alkyldihydroxyethylaminoacetic acid betaine. Preferably, alkyldimethylaminoacetic acid betaine, alkylamidopropyldimethylaminoacetic acid betaine, and alkyldihydroxyethylaminoacetic acid betaine are included. More preferably, alkyldimethylaminoacetic acid betaine is included.

[0048] Aminoacetic acid betaine-type amphoteric surfactants may be used alone or in combination of two or more types.

[0049] Alkyldimethylaminoacetic acid betaine is represented by the following general formula (1).

[0050] [ka]

[0051] In the above equation (1), R 1R1 represents a linear or branched alkyl group having 8 to 22 carbon atoms. Preferably, it represents a linear or branched alkyl group having 8 to 18 carbon atoms. Examples of R1 include a decyl group, a lauryl group, a myrstyl group, a palmityl group, a stearyl group, and an oleyl group. Preferably, it is a lauryl group.

[0052] Examples of alkyldimethylaminoacetic acid betaines include lauryldimethylaminoacetic acid betaine, myristyldimethylaminoacetic acid betaine, and stearyldimethylaminoacetic acid betaine. Lauryldimethylaminoacetic acid betaine is preferred.

[0053] Furthermore, in the above general formula (1), R is used for the aminoacetic acid betaine type amphoteric surfactant. 1 The hydrocarbon group is a linear or branched hydrocarbon group having 8 to 22 carbon atoms, and may have a double bond in part of it. For example, coconut oil alkyldimethylaminoacetic acid betaine is an example of this.

[0054] Alkylamidopropyldimethylaminoacetic acid betaine is represented by the following general formula (2).

[0055] [ka]

[0056] In equation (2) above, R 2 R represents a linear or branched alkyl group having 8 to 22 carbon atoms. Preferably, it represents a linear or branched alkyl group having 10 to 18 carbon atoms. 2 Examples of such groups include decyl groups, lauryl groups, myrstyl groups, palmityl groups, stearyl groups, and oleyl groups. Preferably, lauryl groups and myrstyl groups are used.

[0057] Examples of alkylamidopropyldimethylaminoacetic acid betaines include lauramidopropyl betaine (lauramidopropyl betaine) and myristamidopropyl betaine.

[0058] Furthermore, in the above general formula (2), R is used for the aminoacetic acid betaine type amphoteric surfactant. 2 The hydrocarbon group may be a linear or branched hydrocarbon group having 8 to 22 carbon atoms, and may have a double bond in part of it. Examples include coconut oil fatty acid amidopropyl betaine (cocamidopropyl betaine), palm oil fatty acid amidopropyl betaine, undecylenamidopropyl betaine, oleamidopropyl betaine, and ricinoleic acid amidopropyl betaine.

[0059] Alkyldihydroxyethylaminoacetic acid betaine is represented by the following general formula (3).

[0060] [ka]

[0061] In equation (3) above, R 3 R represents a linear or branched alkyl group having 8 to 22 carbon atoms. Preferably, it represents a linear or branched alkyl group having 10 to 18 carbon atoms. 3 Examples of such groups include the decyl group, lauryl group, myrstyl group, palmityl group, stearyl group, and oleyl group. Stearyl group is preferred.

[0062] Examples of alkyldihydroxyethylaminoacetic acid betaines include stearyldihydroxyethylbetaine.

[0063] Furthermore, in the above general formula (3), R is used for the aminoacetic acid betaine type amphoteric surfactant. 3 This may be a linear or branched hydrocarbon group having 8 to 22 carbon atoms, and may have a double bond in part of it.

[0064] The above-mentioned aminoacetic acid betaine-type amphoteric surfactants are commercially available. Specifically, examples of lauryldimethylaminoacetic acid betaine include Anhitol 20BS (manufactured by Kao Corporation, hereinafter the same) and Anhitol 24B. An example of stearyldimethylaminoacetic acid betaine is Anhitol 86B. An example of lauric acid amidopropyl betaine is Anhitol 20AB. An example of coconut oil fatty acid amidopropyl betaine is Anhitol 55AB.

[0065] The mass ratio of aminoacetic acid betaine-type amphoteric surfactant to OIT is, for example, 0.10 to 5.0, preferably 0.20 to 4.5, more preferably 0.25 to 4.0, even more preferably 0.30 to 4.0, and particularly preferably 0.33 to 4.0.

[0066] The mass ratio of the aminoacetic acid betaine type amphoteric surfactant to OIT is, for example, 0.10 or more, preferably 0.20 or more, more preferably 0.25 or more, even more preferably 0.30 or more, and particularly preferably 0.33 or more. Furthermore, there is no particular upper limit to the mass ratio of the aminoacetic acid betaine type amphoteric surfactant to OIT. The mass ratio of the aminoacetic acid betaine type amphoteric surfactant to OIT is, for example, 5.0 or less, preferably 4.5 or less, and more preferably 4.0 or less.

[0067] If the mass ratio of the aminoacetic acid betaine-type amphoteric surfactant to OIT is above the lower limit, OIT can be solubilized in water. Furthermore, if the mass ratio of the aminoacetic acid betaine-type amphoteric surfactant to OIT is below the upper limit, the increase in cost can be suppressed. In addition, when the microbial control agent of this disclosure is used in appropriate combination with other materials depending on the application, the influence of the aminoacetic acid betaine-type amphoteric surfactant can be suppressed.

[0068] The amount of aminoacetic acid betaine-type amphoteric surfactant blended per 100 parts by mass of solvent is, for example, 0.1 parts by mass or more, preferably 0.3 parts by mass or more, and more preferably 0.5 parts by mass or more. Furthermore, there is no particular upper limit to the amount of aminoacetic acid betaine-type amphoteric surfactant blended per 100 parts by mass of solvent. The amount of aminoacetic acid betaine-type amphoteric surfactant blended per 100 parts by mass of solvent is, for example, 20 parts by mass or less, preferably 10 parts by mass or less, more preferably 7 parts by mass or less, and even more preferably 5 parts by mass or less.

[0069] The amount of aminoacetic acid betaine-type amphoteric surfactant blended per 100 parts by mass of water in the solvent is, for example, 0.3 parts by mass or more, preferably 0.5 parts by mass or more, and more preferably 0.7 parts by mass or more. Furthermore, there is no particular upper limit to the amount of aminoacetic acid betaine-type amphoteric surfactant blended per 100 parts by mass of water in the solvent. The amount of aminoacetic acid betaine-type amphoteric surfactant blended per 100 parts by mass of water in the solvent is, for example, 30 parts by mass or less, preferably 20 parts by mass or less, more preferably 15 parts by mass or less, and even more preferably 10 parts by mass or less.

[0070] If the amount of aminoacetic acid betaine-type amphoteric surfactant blended with 100 parts by mass of water in the solvent is equal to or greater than the lower limit mentioned above, OIT can be more reliably solubilized in water.

[0071] The content of the aminoacetic acid betaine type amphoteric surfactant in the microbial control agent is, for example, 0.10% to 15.0% by mass, preferably 0.20% to 10.0% by mass, more preferably 0.25% to 5.0% by mass, and even more preferably 0.30% to 5.0% by mass.

[0072] The content of the aminoacetic acid betaine type amphoteric surfactant in the microbial control agent is, for example, 0.10% by mass or more, preferably 0.20% by mass or more, more preferably 0.25% by mass or more, and even more preferably 0.30% by mass or more. Furthermore, there is no particular upper limit to the content of the aminoacetic acid betaine type amphoteric surfactant in the microbial control agent. The content of the aminoacetic acid betaine type amphoteric surfactant in the microbial control agent is, for example, 15.0% by mass or less, preferably 10.0% by mass or less, and more preferably 5.0% by mass or less.

[0073] If the content of the aminoacetic acid betaine-type amphoteric surfactant in the microbial control agent is above the lower limit mentioned above, OIT can be solubilized more reliably. Furthermore, if the content of the aminoacetic acid betaine-type amphoteric surfactant in the microbial control agent is below the upper limit mentioned above, the increase in cost can be suppressed. In addition, when the microbial control agent of this disclosure is used in appropriate combination with other materials depending on the application, the influence of the aminoacetic acid betaine-type amphoteric surfactant can be suppressed.

[0074] 3. Solvent The solvent dissolves each of the above-mentioned active ingredients. Examples of solvents include water and organic solvents. The microbial control agent of this embodiment contains water as the solvent.

[0075] The water used is not particularly limited as long as it is the type commonly used in microbial control agents, and examples include distilled water, deionized water (ion-exchanged water), and ultrapure water.

[0076] Examples of organic solvents include alcohols, ketones such as acetone and methyl ethyl ketone, cyclic ethers such as tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatics such as toluene, halogenated hydrocarbons such as chloroform, and polar solvents such as N-methylpyrrolidone. Alcohols are preferred.

[0077] Examples of alcohols include monohydric alcohols and dihydric alcohols. Examples of monohydric alcohols include monohydric alkyl alcohols and glycol monoethers. Examples of monohydric alkyl alcohols include methanol, ethanol, propyl alcohol, and isopropyl alcohol. Examples of glycol monoethers include ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, and tripropylene glycol monomethyl ether. Examples of dihydric alcohols include ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, and 1,4-butanediol.

[0078] Preferred solvents include water and alcohols. More preferably, water, diethylene glycol, ethylene glycol monomethyl ether, and diethylene glycol monomethyl ether are used.

[0079] The solvent may be used alone or in combination of two or more. Preferably, water may be used alone, or water may be used in combination with an organic solvent. More preferably, water may be used in combination with an organic solvent. Even more preferably, water may be used in combination with an alcohol. Specifically, water may be used in combination with at least one selected from the group consisting of diethylene glycol, ethylene glycol monomethyl ether, and diethylene glycol monomethyl ether.

[0080] When the solvent is a combination of water and an organic solvent, the water content in the solvent is, for example, 10% by mass or more, preferably 20% by mass or more, more preferably 30% by mass or more, even more preferably 40% by mass or more, and also, for example, 95% by mass or less, preferably 85% by mass or less, more preferably 75% by mass or less, even more preferably 65% ​​by mass or less, and particularly preferably 60% by mass or less.

[0081] In this embodiment, OIT can be solubilized in water even though the water content in the solvent is above the lower limit. Furthermore, if the water content in the solvent is above the lower limit, cost increases can be suppressed, and the safety of the microbial control agent can be improved. In other words, it offers excellent handling properties.

[0082] The solvent content in the microbial control agent is, for example, 30% by mass or more, preferably 50% by mass or more, more preferably 60% by mass or more, even more preferably 65% ​​by mass or more, and also, for example, 99% by mass or less, preferably 98% by mass or less.

[0083] Furthermore, the solvent content in microbial control agents is the remainder of the microbial control component, the aminoacetic acid betaine-type amphoteric surfactant, the stabilizer added as needed, and the other additives added as needed.

[0084] The water content in the microbial control agent is, for example, 5% by mass or more, preferably 10% by mass or more, more preferably 15% by mass or more, even more preferably 20% by mass or more, particularly preferably 25% by mass or more, and also, for example, 80% by mass or less, preferably 70% by mass or less, more preferably 60% by mass or less.

[0085] In this embodiment, OIT can be solubilized in water even though the water content in the microbial control agent is above the lower limit mentioned above. If the water content in the microbial control agent is above the lower limit, cost increases can be suppressed, and the safety of the microbial control agent can be improved. In other words, it offers excellent handling advantages.

[0086] 4. Stabilizer Stabilizers improve the stability of microbial control agents and / or the stability of the active ingredients (including OIT) contained in the microbial control agent. Furthermore, if the microbial control agent contains a stabilizer, OIT can be solubilized even when the water content in the microbial control agent is low. In other words, it improves the compatibility between OIT and water.

[0087] Examples of stabilizers include water-soluble inorganic compounds. Examples of inorganic compounds include chlorides, sulfates, phosphates, and nitrates. Nitrates are preferred.

[0088] Examples of chlorides include sodium chloride, potassium chloride, lithium chloride, calcium chloride, and magnesium chloride. Examples of sulfates include sodium sulfate, potassium sulfate, magnesium sulfate, and aluminum sulfate. Examples of phosphates include sodium phosphate and potassium phosphate.

[0089] Examples of nitrates include sodium nitrate, potassium nitrate, calcium nitrate, magnesium nitrate, zinc nitrate, cobalt nitrate, nickel nitrate, bismuth nitrate, tin nitrate, strontium nitrate, cesium nitrate, and cerium nitrate. Magnesium nitrate is preferred.

[0090] The amount of stabilizer added per 100 parts by mass of solvent is, for example, 0.5 parts by mass or more, preferably 3.0 parts by mass or more, more preferably 5.0 parts by mass or more, even more preferably 10 parts by mass or more, or, for example, 100 parts by mass or less, preferably 80 parts by mass or less, more preferably 60 parts by mass or less, even more preferably 50 parts by mass or less.

[0091] There is no particular lower limit to the amount of stabilizer added per 100 parts by mass of water in the solvent. The amount of stabilizer added per 100 parts by mass of water in the solvent is, for example, 1.0 part by mass or more, preferably 5.0 parts by mass or more, more preferably 10 parts by mass or more, and even more preferably 20 parts by mass or more. Alternatively, the amount of stabilizer added per 100 parts by mass of water in the solvent is, for example, 150 parts by mass or less, preferably 120 parts by mass or less, more preferably 100 parts by mass or less, and even more preferably 90 parts by mass or less.

[0092] There is no particular lower limit to the content of stabilizers in microbial control agents. The content of stabilizers in microbial control agents is, for example, 0.1% by mass or more, preferably 1.0% by mass or more, more preferably 5.0% by mass or more, even more preferably 8.0% by mass or more, and especially preferably 10% by mass or more. Alternatively, the content of stabilizers in microbial control agents is, for example, 50% by mass or less, preferably 40% by mass or less, and more preferably 30% by mass or less.

[0093] If the content of the stabilizer in the microbial control agent is above the lower limit mentioned above, the compatibility of OIT with water can be further improved. Also, if the content of the stabilizer in the microbial control agent is below the upper limit mentioned above, the content of the active ingredient can be ensured.

[0094] 5. Other additives The microbial control agents of this disclosure may contain known additives depending on their purpose and use. Other additives include, for example, surfactants (excluding aminoacetic acid betaine type amphoteric surfactants), stabilizers (excluding inorganic compounds), and antioxidants. The microbial control agents of this disclosure preferably do not contain surfactants (excluding aminoacetic acid betaine type amphoteric surfactants).

[0095] Examples of surfactants include nonionic surfactants, cationic surfactants, anionic surfactants, and amphoteric surfactants (excluding aminoacetic acid betaine-type amphoteric surfactants).

[0096] Examples of nonionic surfactants include polyoxyalkylene alkyl ethers, polyoxyalkylene alkenyl ethers, sorbitan fatty acid esters, polyoxyalkylene sorbitan fatty acid esters, polyoxyalkylene fatty acid esters, alkyl glucosides, alkyl polyglycosides, alkyl glyceryl ethers, alkenyl glyceryl ethers, higher fatty acid sucrose esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, alkyl saccharides, alkylamine oxides, alkylamidoamine oxides, fatty acid alkanolamides, polyoxyalkylene fatty acid alkanolamides, and (poly)ethylene glycol fatty acid esters. Examples of polyoxyalkylene alkyl ethers include polyoxyethylene alkyl ethers, specifically polyoxyethylene lauryl ethers, polyoxyethylene cetyl ethers, and polyoxyethylene stearyl ethers.

[0097] Examples of cationic surfactants include alkyltrimethylammonium salts, alkoxyalkyltrimethylammonium salts, dialkyldimethylammonium salts, alkylamidealkyltrimethylammonium salts, alkyldimethylamines and their salts, alkoxyalkyldimethylamines and their salts, and alkylamidealkyldimethylamines and their salts.

[0098] Examples of anionic surfactants include alkylbenzene sulfonates, alkyl or alkenyl ether sulfates, alkyl or alkenyl sulfates, alkyl sulfonates, saturated or unsaturated fatty acid salts, alkyl or alkenyl ether carboxylates, α-sulfo fatty acid salts, N-acyl amino acids, mono or diester phosphates, sulfosuccinates, and amino acid-based surfactants. Examples of counterions to the anionic group of anionic surfactants include alkali metal ions, alkaline earth metal ions, ammonium ions, and alkanolammonium having 1 to 3 C2 or C3 alkanol groups (e.g., monoethanolammonium, diethanolammonium).

[0099] Examples of amphoteric surfactants (excluding aminoacetic acid betaine type amphoteric surfactants) include betaine type amphoteric surfactants (excluding aminoacetic acid betaine type amphoteric surfactants), amine oxide type amphoteric surfactants, and amino acid type amphoteric surfactants. Examples of betaine type amphoteric surfactants (excluding aminoacetic acid betaine type amphoteric surfactants) include sulfobetaine type amphoteric surfactants such as alkyl sulfobetaine and alkyl hydroxy sulfobetaine, imidazoline-based betaine type amphoteric surfactants, and phosphobetaine type amphoteric surfactants. Examples of alkyl sulfobetaine include lauryl dimethyl sulfoethyl betaine, lauryl dimethyl sulfopropyl betaine, myristyl dimethyl sulfoethyl betaine, myristyl dimethyl sulfopropyl betaine, stearyl dimethyl sulfoethyl betaine, stearyl dimethyl sulfopropyl betaine, and coconut oil fatty acid dimethyl sulfopropyl betaine. Examples of alkylhydroxysulfobetaines include lauryldimethylsulfo(hydroxyethyl)betaine, lauryldimethylsulfo(hydroxypropyl)betaine, myristyldimethylsulfo(hydroxyethyl)betaine, myristyldimethylsulfo(hydroxypropyl)betaine, stearyldimethylsulfo(hydroxypropyl)betaine, bis-(2-hydroxyethyl)sulfoethylbetaine, and laurylbis-(2-hydroxyethyl)sulfopropylbetaine. Examples of imidazoline-based betaine-type amphoteric surfactants include N-acylaminoethyl-N-2-hydroxyethylaminocarboxylate salts, such as N-coconut oil fatty acid acyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine, N-coconut oil fatty acid acyl-N'-carboxyethyl-N'-hydroxyethylethylenediamine, and sodium N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine. Examples of phosphobetaine-type amphoteric surfactants include laurylhydroxyphosphobetaine.

[0100] Examples of stabilizers (excluding inorganic compounds) include azole compounds (e.g., 1,2,4-triazole) and chelating agents. Examples of chelating agents include ethylenediaminetetraacetic acid, nitrilotriacetic acid, methylglycine diacetic acid, hydroxyethylenediaminetriacetic acid, diethylenetriaminopentaacetic acid, triethylenetetraaminehexaacetic acid, hydroxyethyliminodiacetic acid, dihydroxyethylglycine, glutamic acid diacetic acid, aspartic acid diacetic acid, β-alanine diacetic acid, serine diacetic acid, tripolyphosphate, and alkali metal salts thereof.

[0101] Furthermore, the microbial control agents of this disclosure may contain other algal and / or fungicides, depending on their purpose and use.

[0102] The microbial control agents disclosed herein exhibit control effects against bacteria, molds, yeasts, and algae. Therefore, they can be suitably used as control agents for these organisms (i.e., fungicides, fungicides, and algalicides), and are particularly suitable for use as industrial disinfectant compositions.

[0103] Specifically, the microbial control agents of this disclosure are used in various industrial products such as, for example, industrial water in paper and pulp mills and cooling water circulation processes, metalworking fluids such as cutting oils, casein, starch paste, glue, emulsions, coated paper, paper coating liquids, surface sizing agents, paper strength enhancers, paints, adhesives, synthetic rubber latex, printing inks, polyvinyl alcohol films, vinyl chloride films, plastic products, cement admixtures, building materials, sealants, joint fillers, deodorizers, and leather products.

[0104] Furthermore, the microbial control agents disclosed herein can be used after being appropriately diluted depending on the target organism, the type of microorganism (bacteria, fungi, yeasts, algae, etc.), and the control period.

[0105] 6. Effects (1) The microbial control agent of this disclosure contains a microbial control component including OIT and an aminoacetic acid betaine type amphoteric surfactant. Therefore, OIT can be solubilized.

[0106] (2) In the microbial control agent of this disclosure, the mass ratio of the aminoacetic acid betaine type amphoteric surfactant to OIT is 0.20 or higher. Therefore, OIT can be solubilized more reliably.

[0107] (3) In the microbial control agent of this disclosure, the mass ratio of aminoacetic acid betaine-type amphoteric surfactant to OIT is 4.5 or less. Therefore, cost increases can be suppressed.

[0108] (4) The microbial control agent of this disclosure contains an aminoacetic acid betaine-type amphoteric surfactant of 0.25% by mass or more. Therefore, OIT can be solubilized more reliably.

[0109] (5) The microbial control agent disclosed herein contains an aminoacetic acid betaine-type amphoteric surfactant of 5.0% by mass or less. Therefore, cost increases can be suppressed.

[0110] (6) The microbial control agent of this disclosure has an OIT content of 10% by mass or more in the microbial control component. Therefore, microorganisms can be controlled more reliably. In addition, since the microbial control agent contains an aminoacetic acid betaine type amphoteric surfactant, even if the OIT content in the microbial control component is 10% by mass or more, the OIT can be solubilized in water.

[0111] (7) The microbial control agent disclosed herein contains 0.1% by mass or more of OIT. Therefore, it can control microorganisms more reliably.

[0112] (8) The microbial control agent of this disclosure further contains a hydrophilic microbial control component. Therefore, microorganisms can be controlled more reliably while ensuring compatibility between OIT and water.

[0113] (9) The microbial control agent of this disclosure further contains a stabilizer. Therefore, even if the water content in the microbial control agent is low, OIT can be solubilized. [Examples]

[0114] The present disclosure will be further explained by the following examples, but this disclosure is not limited thereto. Specific numerical values ​​such as formulation ratios (concentrations), physical properties, and parameters used in the following description may be replaced with the corresponding upper limits (numbers defined as "less than or equal to" or "less than") or lower limits (numbers defined as "greater than or equal to" or "greater than") of the formulation ratios (concentrations), physical properties, and parameters described in the "Modes for Carrying Out the Invention" above. Note that "parts" and "%" refer to mass unless otherwise specified.

[0115] Example 1 In a 6K glass bottle, the following were weighed in proportions as shown in Preparation Example 1 in Table 1: BNPD (2-bromo-2-nitro-1,3-propanediol (hydrophilic microbial control component), manufactured by Jiangsu Wode Chemical Co., Ltd.) and OIT (2-n-octyl-4-isothiazolin-3-one, manufactured by Tokyo Chemical Industry Co., Ltd.) as microbial control components, and lauryldimethylaminoacetic acid betaine (trade name "Anhitol 20BS", solids content: 30% by mass, manufactured by Kao Corporation) as an aminoacetic acid betaine type amphoteric surfactant, along with DEG (diethylene glycol) and deionized water. The mixture was then stirred at room temperature (25°C) to obtain the microbial control agent of Example 1. Note that the surfactant content percentages listed in Table 1 refer to the content percentage of lauryldimethylaminoacetic acid betaine. In other words, the water contained in Anhitol 20BS is listed as water in Table 1, together with the deionized water mentioned above.

[0116] Comparative Example 1 As shown in Preparation Example 2 of Table 1, the microbial control agent for Comparative Example 1 was obtained in the same manner as in Example 1, except that deionized water was added instead of the aminoacetic acid betaine-type amphoteric surfactant. In other words, no surfactant was added in Comparative Example 1.

[0117] Comparative Examples 2-21 Comparative Examples 2 to 21 were obtained in the same manner as in Example 1, except that the surfactants shown in Table 2 were used instead of the aminoacetic acid betaine type amphoteric surfactant. The surfactants shown in Table 2 were formulated so that the components (excluding the solvent) of each surfactant were in the proportions shown in Table 1.

[0118] Examples 2, 3 As shown in Table 3, the microbial control agents of Examples 2 and 3 were obtained in the same manner as in Example 1, except that the proportions of lauryldimethylaminoacetic acid betaine and deionized water were changed.

[0119] Comparative Examples 22, 23 As shown in Table 3, microbial control agents for Comparative Examples 22 and 23 were obtained in the same manner as for Comparative Example 2, except that the proportions of the surfactant (lauryl hydroxysulfobetaine (trade name "Anhitol 20HD", manufactured by Kao Corporation)) and deionized water were changed.

[0120] Examples 4-8 Except for adding magnesium nitrate hexahydrate as a stabilizer in the proportions shown in Table 4, and further changing the proportions of lauryldimethylaminoacetic acid betaine and deionized water as shown in Table 4, microbial control agents for Examples 4 to 8 were obtained in the same manner as in Example 1.

[0121] Examples 9-11 As shown in Table 5, the microbial control agents of Examples 9 to 11 were obtained in the same manner as in Example 1, except that MITs (2-methyl-4-isothiazolin-3-one (hydrophilic microbial control component), manufactured by Dalian Baiao Chemical Co., Ltd.) were used instead of BNPD, and the proportions of lauryldimethylaminoacetic acid betaine and deionized water were changed. In other words, the microbial control agents of Examples 9 to 11 consist of MITs and OIT as microbial control components.

[0122] Examples 12-14 Except for using IAA (iodoacetamide (hydrophilic microbial control component), manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) instead of BNPD, and changing the proportions of lauryldimethylaminoacetic acid betaine and deionized water as shown in Table 5, the microbial control agents of Examples 12 to 14 were obtained in the same manner as in Example 1. In other words, the microbial control agents of Examples 12 to 14 consist of IAA and OIT as microbial control components.

[0123] Comparative Examples 24, 25 As shown in Table 5, a microbial control agent for Comparative Example 24 was obtained in the same manner as in Example 9, except that deionized water was added instead of the aminoacetic acid betaine type amphoteric surfactant. Also, as shown in Table 5, a microbial control agent for Comparative Example 25 was obtained in the same manner as in Example 12, except that deionized water was added instead of the aminoacetic acid betaine type amphoteric surfactant. In other words, the microbial control agent for Comparative Example 24 consists of MITs and OIT as microbial control components, and the microbial control agent for Comparative Example 25 consists of IAA and OIT as microbial control components.

[0124] Examples 15-17 As shown in Table 6, the microbial control agents of Examples 15-17 were obtained in the same manner as in Example 1, except that BNPD was not added and the ratios of OIT and deionized water were changed. In other words, the microbial control agents of Examples 15-17 consist of OIT as the microbial control component.

[0125] Comparative Examples 26-28 As shown in Table 6, comparative examples 26-28 were obtained in the same manner as in Example 15, except that the aminoacetic acid betaine-type amphoteric surfactant was omitted and the ratio of OIT and deionized water was changed. In other words, the microbial control agents of comparative examples 26-28 consist of OIT as the microbial control component.

[0126] (Compatibility evaluation) The microbial control agents for each example and comparative example were placed in lidded glass containers (2K glass bottles) immediately after preparation. The compatibility of the microbial control agents was then evaluated by visual observation under natural light according to the following criteria. The results are shown in Tables 1 to 6.

[0127] Furthermore, the microbial control agents for each example and comparative example were placed in lidded glass containers (2K glass bottles) and stored at room temperature. After 2 hours of storage, the microbial control agents were observed visually under natural light, and their compatibility was evaluated according to the following criteria. The results are shown in Tables 1 to 6. In addition, the microbial control agents were observed visually under natural light after 1 day (24 hours) of storage, and their compatibility was evaluated according to the following criteria. The results are shown in Tables 1 to 6.

[0128] (Criteria for evaluating compatibility) The following criteria were used to evaluate compatibility. A: It is a transparent solution (it is in a miscible state). B: It is cloudy (emulsified). C: Separated

[0129] [Table 1]

[0130] [Table 2]

[0131] [Table 3]

[0132] [Table 4]

[0133] [Table 5]

[0134] [Table 6]

[0135] In Table 2, the names of surfactants in parentheses indicate their brand names. The surfactants used in Comparative Examples 2-19 were manufactured by Kao Corporation, the surfactant used in Comparative Example 20 was manufactured by Sanyo Chemical Industries, Ltd., and the surfactant used in Comparative Example 21 was manufactured by Shiozuiko Sugar Refining Co., Ltd.

Claims

1. Microbial control components, Aminoacetic acid betaine type amphoteric surfactant and It contains, The aforementioned microbial control component is a microbial control agent containing 2-n-octyl-4-isothiazolin-3-one.

2. The microbial control agent according to claim 1, wherein the mass ratio of the aminoacetic acid betaine-type amphoteric surfactant to the 2-n-octyl-4-isothiazolin-3-one is 0.20 or more.

3. The microbial control agent according to claim 1, wherein the mass ratio of the aminoacetic acid betaine-type amphoteric surfactant to the 2-n-octyl-4-isothiazolin-3-one is 4.5 or less.

4. The microbial control agent according to claim 1, wherein the content of the aminoacetic acid betaine-type amphoteric surfactant in the microbial control agent is 0.25% by mass or more.

5. The microbial control agent according to claim 1, wherein the content of the aminoacetic acid betaine-type amphoteric surfactant in the microbial control agent is 5.0% by mass or less.

6. The microbial control agent according to claim 1, wherein the content of 2-n-octyl-4-isothiazolin-3-one in the microbial control component is 10.0% by mass or more.

7. The microbial control agent according to claim 1, wherein the content of 2-n-octyl-4-isothiazolin-3-one in the microbial control agent is 0.1% by mass or more.

8. The microbial control agent according to any one of claims 1 to 7, wherein the microbial control component further comprises a hydrophilic microbial control component.

9. The microbial control agent according to claim 8, further containing a stabilizer.

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