Oral rinse

Abstract

The present invention provides an oral rinse that effectively cleans the inside of the mouth and prevents contamination of the washing area (sink) after oral cleaning. [Solution] An oral cleansing agent comprising (a) vegetable oil and (b) a water-soluble emulsifier, An oral cleanser is used in which the content of component (a) is 70% by mass or more of the total amount of the oral cleanser.

Description

Technical Field

[0001] The present invention relates to an oral cleanser.

Background Art

[0002] Conventionally, various products have been developed and launched as compositions for oral care such as periodontal disease prevention and bad breath suppression (Patent Document 1). For example, in Ayurveda, vegetable oils such as sesame oil and coconut oil are often used as oral cleansers. Such oral cleansers are considered advantageous in that they can easily rinse off stains that are poorly soluble in water.

[0003] On the other hand, although vegetable oils used in Ayurveda have high safety to the oral mucosa, they have a problem that some people are reluctant to put them in the mouth depending on their taste and odor. In addition, if the vegetable oil after oral cleansing is poured directly into a washbasin, problems such as staining of the washbasin and clogging of drain pipes will occur, and post-treatment will be more troublesome compared to the post-treatment of water-based oral cleansers.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of Invention

[0005] The present invention provides an oral cleanser.

[0006] The present inventors have found that the use of an oral cleanser containing a specific oil and a surfactant can effectively cleanse the oral cavity and avoid staining of a washbasin (sink) or the like after oral cleansing.

[0007] According to one embodiment of the present invention, there is provided an oral cleanser comprising (a) a vegetable fat or oil, and (b) a water-soluble emulsifier, wherein the content of component (a) is 70% by mass or more relative to the total amount of the oral cleanser.

[0008] According to the present invention, it is possible to effectively clean the inside of the mouth and avoid soiling of the washing area (sink) etc. after oral cleaning. Furthermore, the oral cleaning agent of the present invention can be advantageously used to achieve both a good taste and smell and good cleaning performance. [Brief explanation of the drawing]

[0009] [Figure 1] Figure 1 is a photograph of a mixture obtained by mixing the oral cleansing agent of the present invention with purified water. Detailed description of the invention

[0010] According to one embodiment of the present invention, the oral cleanser comprises (a) vegetable oil and fat, and (b) a water-soluble emulsifier, wherein the content of component (a) is 70% by mass or more of the total amount of the oral cleanser.

[0011] The oral cleansing agent of the present invention utilizes the emulsifying action produced by mixing oral fluids containing water, such as saliva, with components (a) and (b) to effectively clean the oral cavity and prevent staining of the washing area (sink) after oral cleaning. This emulsification may be an oil-in-water type emulsification or an oil-in-water type emulsification, but it is preferably an oil-in-water type emulsification. Furthermore, this emulsification can be achieved more effectively the lower the water content in the oral cleansing agent of the present invention. Therefore, the oral cleansing agent of the present invention preferably contains substantially no water, and specifically, the water content in the oral cleansing agent of the present invention is preferably less than 1% by mass, more preferably less than 0.5% by mass, and more preferably 0% by mass. The oral fluid in the present invention is not particularly limited, but is preferably saliva.

[0012] In the present invention, effective cleaning of the oral cavity can be achieved, for example, by emulsifying the oral cleansing agent of the present invention with bodily fluids in the oral cavity, thereby making the cleaning ability of the oral cleansing agent of the present invention equal to or greater than the cleaning ability of the vegetable oil corresponding to component (a) used as is, that is, by not reducing the cleaning power of the vegetable oil. Here, not reducing the cleaning power of the vegetable oil means not reducing it substantially, and does not mean that even a slight reduction in cleaning power is unacceptable.

[0013] The oral cleansing agent of the present invention can be disposed of by pouring it down a sink or the like after oral cleaning. In other words, the mixture formed by mixing the oral cleansing agent of the present invention with bodily fluids does not adhere much to the surface of the sink or drainpipe, or if it does adhere, it can be easily washed away with running water. This can be achieved, for example, by causing emulsification when mixing the oral cleansing agent of the present invention with bodily fluids in the mouth, thereby reducing the adhesion of the mixture formed by mixing the oral cleansing agent with bodily fluids to the surface.

[0014] The material of the surface in this invention is not particularly limited and includes, for example, metal, plastic, stone, composite material, etc. Furthermore, the location of the surface in this invention is not particularly limited and may be located on, for example, a washing counter (sink), a drain pipe, etc.

[0015] According to one preferred embodiment of the present invention, the oral cleanser of the present invention causes emulsification by mixing with bodily fluids in the oral cavity, thereby reducing the adhesion of the mixture formed by mixing the oral cleanser with bodily fluids to the surface without reducing the cleansing power of vegetable oils.

[0016] According to another preferred embodiment of the present invention, the oral cleansing agent of the present invention is intended to clean the oral cavity by emulsifying when mixed with bodily fluids in the oral cavity.

[0017] Furthermore, in the oral cleansing agent of the present invention, in order to achieve both a good taste and smell and good cleansing performance, the type of appropriate component (a) or (b) can be appropriately selected, or the amount thereof can be appropriately adjusted.

[0018] The content of component (a) relative to the total amount of the oral cleansing agent of the present invention is not particularly limited as long as it is 70% by mass or more, but is preferably 80% by mass or more, and more preferably 90% by mass or more.

[0019] Component (a) in the present invention is not particularly limited as long as it is a vegetable oil, but examples include rice oil, medium-chain fatty acid oil, sesame oil, coconut oil, sunflower oil, corn oil, flaxseed oil, olive oil, etc. Preferably, as component (a) in the present invention, one or more selected from the group consisting of rice oil, medium-chain fatty acid oil, sesame oil, coconut oil, sunflower oil, corn oil, and flaxseed oil is used, more preferably one or more selected from the group consisting of rice oil, medium-chain fatty acid oil, and sesame oil is used, and more preferably one or more selected from the group consisting of rice oil and medium-chain fatty acid oil is used. Component (a) in the present invention may be used alone or in combination of two or more.

[0020] In this invention, rice bran oil refers to the oil obtained from rice bran. Generally, among rice bran oils, those containing a relatively large amount of γ-oryzanol are called rice germ oil. Rice germ oil is also included in the rice bran oil of this invention. If commercially available rice bran oil is available, it may be used in this invention. For example, products such as "PRO-15" and "Rice Oil" manufactured by Tsukuno Foods Industry Co., Ltd. can be used.

[0021] In this invention, medium-chain fatty acid oil refers to glycerides composed of saturated fatty acids having 8 to 12 carbon atoms, and preferably glycerides composed of saturated fatty acids having 8 to 10 carbon atoms. In this invention, the medium-chain fatty acid oil may be any of the medium-chain fatty acid triglycerides, diglycerides, or monoglycerides.

[0022] The sesame oil in the present invention means an oil or fat obtained by pressing and / or extracting sesame seeds. The sesame oil in the present invention may be an oil or fat obtained by pre-roasting sesame seeds and then pressing to impart a unique flavor and color tone, or may be obtained by pressing raw sesame seeds.

[0023] The coconut oil in the present invention means an oil or fat obtained using coconut as a raw material. The coconut oil in the present invention can be produced, for example, by a known method using endosperm (meat) extracted from coconut fruit.

[0024] The sunflower oil in the present invention means an oil or fat obtained from sunflower seeds as a raw material, and is also referred to as sunflower oil.

[0025] The corn oil in the present invention means an oil or fat obtained from corn germ as a raw material, and is also referred to as corn oil. The amount of lecithin contained in the corn oil in the present invention is not particularly limited, but based on the total amount of the corn oil, it is preferably 0.2% by mass or less, more preferably 0.15% by mass or less, more preferably 0.10% by mass or less, more preferably 0.05% by mass or less, and still more preferably not contained.

[0026] The linseed oil in the present invention means a vegetable oil collected from seeds of Linum usitatissimum belonging to the genus Linum in the family Linaceae, and is also referred to as linseed oil or flaxseed oil.

[0027] The content of component (b) relative to the total amount of the oral cleanser of the present invention is not particularly limited, but is preferably 0.1 to 10% by mass, and more preferably 0.5 to 5% by mass.

[0028] According to one embodiment of the present invention, component (b) in the present invention is a surfactant having an HLB value of 7 or more, preferably sucrose stearate or PEG-20 glyceryl triisostearate, and more preferably PEG-20 glyceryl triisostearate.

[0029] Furthermore, according to another embodiment of the present invention, component (b) in the present invention is one or more selected from the group consisting of (b1) fatty acid sugar esters and (b2) polyoxyalkylene polyol fatty acid esters with an HLB value of 7 or higher, and is preferably component (b2).

[0030] Component (b1) in the present invention is a fatty acid sugar ester. Such fatty acid sugar esters are preferably one or more selected from the group consisting of sucrose laurate, sucrose myristate, sucrose palmitate, and sucrose stearate, and more preferably sucrose stearate. Component (b1) in the present invention may be used alone or in combination of two or more.

[0031] The content of component (b1) relative to the total amount of the oral cleansing agent of the present invention is not particularly limited, but is preferably 0.1 to 10% by mass, and more preferably 0.5 to 5% by mass.

[0032] Component (b2) in the present invention is a polyoxyalkylene polyol fatty acid ester with an HLB value of 7 or higher, preferably a polyoxyalkylene polyol fatty acid ester with an HLB value of 9 or higher. Examples of such polyoxyalkylene polyol fatty acid esters include PEG-8 glyceryl isostearate, PEG-20 glyceryl triisostearate, PEG-20 glyceryl stearate, and PEG-20 glyceryl isostearate, with PEG-20 glyceryl triisostearate being preferred. Component (b2) in the present invention may be used alone or in combination of two or more types.

[0033] The content of component (b2) relative to the total amount of the oral cleansing agent of the present invention is not particularly limited, but is preferably 0.1 to 10% by mass, and more preferably 0.5 to 5% by mass.

[0034] The oral cleanser of the present invention may further contain (c) an anti-inflammatory agent. The component (c) in the present invention is not particularly limited as long as it is normally usable in the oral cavity, and examples include tannoids, benzydamine, vitamin E, eugenol, physiological saline, phosphate-buffered physiological saline, natural plant antioxidants such as Kuromoji, tea tree, and catechin, chalcone, curcuminoids, carotenoids, elderflower, purple coneflower, centella asiatica, xylitol, glycyrrhetinic acid derivatives, and propolis. The component (c) in the present invention may be used alone or in combination of two or more.

[0035] According to one preferred embodiment of the present invention, component (c) in the present invention comprises Centella asiatica extract.

[0036] In this invention, "Centella asiatica" refers to the plant Centella asiatica, a member of the genus Centella in the family Apiaceae, also known as Hydrocotyle asiatica. While not limited to specific parts, the leaves and the entire plant are preferred for use.

[0037] The method for producing Centella asiatica extract in the present invention is not particularly limited and can be extracted according to methods commonly used in the art. Examples of such extraction methods, though not limited, include hot water extraction, ultrasonic extraction, filtration, reflux extraction, and solvent (e.g., ethanol) extraction. These may be performed individually or in combination of two or more methods. Furthermore, to obtain a high-purity extract, the extract may be extracted one or more times using the same method.

[0038] The type of extraction solvent used for producing Centella asiatica extract in the present invention is not particularly limited, and any solvent known in the art may be used as long as it yields an extract having the desired effect of the present invention. Examples of such solvents, though not limited to them, include water, C1-C4 alcohols, ethyl acetate, acetone, chloroform, etc., and two or more of these may be used in combination.

[0039] If Centella asiatica extract is commercially available, it may be used if it yields an extract that has the desired effect of the present invention.

[0040] The oral cleansing agent of the present invention may further contain other optional additives as needed, provided that they do not impair the effects of the present invention. Examples of such additives include powders, pharmaceuticals, lower alcohols, polyhydric alcohols, antioxidants, preservatives, and fragrances.

[0041] The oral cleansing agent of the present invention may be a liquid, a semi-solid, or a solid, but is preferably a liquid.

[0042] The oral cleansing agent of the present invention may also be a water-in-oil composition.

[0043] According to embodiments of the present invention, the following inventions are provided. (1) An oral cleansing agent comprising (a) vegetable oil and (b) a water-soluble emulsifier, An oral rinse having an amount of component (a) of 70% by mass or more relative to the total amount of the oral rinse. (2) The oral rinse according to (1), wherein the component (a) is one or more vegetable oils selected from the group consisting of rice oil, medium-chain fatty acid oil, sesame oil, coconut oil, sunflower oil, corn oil, and flaxseed oil. (3) The oral cleansing agent according to (1) or (2), wherein the component (a) is one or more vegetable oils selected from the group consisting of rice oil and medium-chain fatty acid oils. (4) The oral cleansing agent according to any one of (1) to (3), wherein the component (b) is a surfactant with an HLB value of 7 or higher. (5) The oral rinse according to any one of (1) to (4), wherein the component (b) is sucrose stearate or PEG-20 glyceryl triisostearate. (6) The oral cleansing agent according to any one of (1) to (5), wherein the bodily fluid in the oral cavity is saliva. (7) The oral cleansing agent according to any one of (1) to (6), further comprising (c) an anti-inflammatory agent. (8) The oral rinse according to (7), wherein the component (c) is Centella asiatica extract. (9) An oral cleanser according to any one of (1) to (8), wherein emulsification occurs when mixed with bodily fluids in the oral cavity, thereby reducing the adhesion of the mixture formed by mixing the oral cleanser with bodily fluids to the surface without reducing the cleansing power of component (a). (10) An oral rinse according to any of (1) to (9), in liquid form. (11) The oral cleansing agent according to any one of (1) to (10), wherein the component (b) is in the form of a solution in which the component (a) is dissolved. (12)(a) One or more oils selected from the group consisting of rice oil, medium-chain triglyceride oil, sesame oil, coconut oil, sunflower oil, corn oil and flaxseed oil, and (b) One or more emulsifiers selected from (b1) and (b2) below: (b1) Fatty acid sugar esters, (b2) Polyoxyalkylene polyol fatty acid esters with an HLB value of 7 or higher An oral cleansing agent comprising, An oral rinse in which the content of component (a) is 70% by mass or more of the total amount of the oral rinse. (13) The oral cleansing agent according to (12), wherein the component (a) comprises one or more oils selected from the group consisting of rice oil, medium-chain fatty acid oil, and sesame oil. (14) The oral cleansing agent according to (12) or (13), wherein the component (a) comprises one or more oils selected from the group consisting of rice oil and medium-chain fatty acid oil. (15) The oral rinse according to any one of (12) to (14), wherein the component (b1) comprises one or more selected from the group consisting of sucrose laurate, sucrose myristate, sucrose palmitate, and sucrose stearate. (16) The oral cleansing agent according to any one of (12) to (15), wherein the (b1) component comprises sucrose stearate. (17) The oral cleansing agent according to any one of (12) to (16), wherein the component (b2) comprises a polyoxyalkylene polyol fatty acid ester with an HLB value of 9 or higher. (18) The oral rinse according to any one of (12) to (17), wherein the component (b2) comprises PEG-20 glyceryl triisostearate. (19) The oral cleansing agent according to any one of (12) to (18), further comprising (c) an anti-inflammatory agent. (20) The oral cleansing agent according to (19), wherein the component (c) comprises Centella asiatica extract. (21) An oral rinse according to any of (12) to (20), in liquid form. [Examples]

[0044] The present invention will be specifically described based on the following examples, but the present invention is not limited to these examples. Unless otherwise specified, the content is expressed in mass percent.

[0045] Selection of oils to be used in oral rinses We selected an oil suitable for use in the oral rinse agent of the present invention. Several types of plant-derived oils (olive oil, rice bran oil, coconut oil, sesame oil, sunflower oil, medium-chain triglyceride oil, corn oil, and flaxseed oil) were prepared as candidate oils, and each sample was subjected to a sensory evaluation of taste and smell. The sensory evaluation was conducted by four trained panelists, and each panelist assigned a score based on a three-level evaluation criterion (in 1-point increments) as shown in Tables 1 and 2 below. The scores were then totaled. A score of 10 or higher was judged as A, 8-9 points as B, and less than 7 points as C.

[0046] Prior to the sensory evaluation, the panelists discussed and agreed on their assessment of taste. They compared each candidate oil with a control product (purified water), assigning "3 points" if no distinctive taste was detected and "1 point" if a distinctive taste was detected, ensuring that each panelist had a common understanding. Similarly, for the assessment of smell, the panelists discussed and agreed on their assessment. They compared each candidate oil with a control product, assigning "3 points" if no distinctive smell was detected and "1 point" if a distinctive smell was detected, ensuring that each panelist had a common understanding.

[0047] [Table 1]

[0048] [Table 2]

[0049] The results of the sensory evaluation are shown in Table 3 below.

[0050] [Table 3]

[0051] Among the candidate oils, rice oil, coconut oil, sesame oil, sunflower oil, medium-chain triglyceride oil, corn oil, and flaxseed oil were shown to be particularly suitable for use in the oral rinse of the present invention.

[0052] Preparation of oral rinse Rice oil (product name: Rice Oil, manufactured by Tsukuno Foods Industry Co., Ltd.) and PEG-20 glyceryl triisostearate (product name: TGI-20, manufactured by Nikko Chemicals Co., Ltd.) were mixed in a mass ratio of 97:3, and the resulting mixture was thoroughly stirred until homogeneous to obtain the oral rinse agent of Example 1. When 1 mL of purified water was added to 5 mL of the oral rinse agent of Example 1 and mixed, it was confirmed that the mixture became cloudy (Figure 1). Therefore, it was shown that the oral rinse agent of Example 1 emulsifies when mixed with water.

[0053] Rice oil (product name: Rice Oil, manufactured by Tsukuno Foods Industry Co., Ltd.) and PEG-5 glyceryl triisostearate (product name: EMALEX GWIS-305EX, manufactured by Nippon Emulsion Co., Ltd.) were mixed in a mass ratio of 97:3, and the resulting mixture was thoroughly stirred until homogeneous to obtain the oral rinse agent of Comparative Example 1.

[0054] Rice oil (product name: Rice Oil, manufactured by Tsukuno Foods Industry Co., Ltd.) and glyceryl monoisostearate (product name: MGIS, manufactured by Nikko Chemicals Co., Ltd.) were mixed in a mass ratio of 97:3, and the resulting mixture was thoroughly stirred until homogeneous to obtain the oral rinse agent of Comparative Example 2.

[0055] Evaluation of the emulsifying effect of the prepared oral rinse. The emulsifying effect of the oral rinse was evaluated by visually assessing the mixed solution of the prepared oral rinse and purified water. 5 mL of the oral rinse from Example 1 and Comparative Examples 1 and 2 was mixed with 1 mL of purified water, and the resulting mixture was thoroughly stirred until homogeneous. The sample was then left to stand at room temperature for 1 hour to be used as the measurement sample. The visual appearance of the measurement sample was evaluated according to the evaluation criteria shown in Table 4 below. As a negative control, 5 mL of rice oil (product name: Rice Oil, manufactured by Tsukuno Foods Industry Co., Ltd.) and 1 mL of purified water were mixed, and the resulting mixture was thoroughly stirred until homogeneous. This sample was then left to stand at room temperature for 1 hour and its visual appearance was also evaluated (Comparative Example 3).

[0056] [Table 4]

[0057] The results of the visual evaluation are shown in Table 5 below.

[0058] [Table 5]

[0059] The results of the visual evaluation showed that the measurement samples prepared using the oral cleanser of the present invention exhibited a good appearance. Therefore, it was suggested that the oral cleanser of the present invention has good emulsifying properties.

[0060] Evaluation of the adhesion properties of the prepared oral rinse. The oral rinsing agents of Example 1 and Comparative Examples 1 and 2 were mixed with 5 mL of oral rinsing agent and 1 mL of purified water. The resulting mixture was thoroughly stirred until homogeneous, and the sample was applied to a ceramic sink. The surface was then quickly rinsed with tap water, and the appearance of the sink after rinsing was evaluated to assess the adhesion of the oral rinsing agent. The appearance was evaluated according to the evaluation criteria shown in Table 6 below. As a negative control, a sample was prepared by mixing 5 mL of rice oil (product name: Rice Oil, manufactured by Tsukuno Foods Industry Co., Ltd.) and 1 mL of purified water, and the resulting mixture was thoroughly stirred until homogeneous. This sample was also applied to a ceramic sink, and the surface was then quickly rinsed with tap water. The appearance of the sink after rinsing was evaluated to assess its adhesion (Comparative Example 3).

[0061] [Table 6]

[0062] The results of the visual evaluation are shown in Table 7 below.

[0063] [Table 7]

[0064] Based on the visual evaluation, no measurement samples prepared using the oral cleanser of the present invention remained on the sink, suggesting that the oral cleanser of the present invention can be thoroughly washed away with tap water.

Claims

1. An oral rinse comprising (a) vegetable oil and (b) a water-soluble emulsifier, An oral rinse having an amount of component (a) of 70% by mass or more relative to the total amount of the oral rinse.

2. The oral cleansing agent according to claim 1, wherein component (a) is one or more vegetable oils selected from the group consisting of rice oil, medium-chain triglyceride oil, sesame oil, coconut oil, sunflower oil, corn oil, and flaxseed oil.

3. The oral cleansing agent according to claim 1, wherein component (a) is one or more vegetable oils selected from the group consisting of rice oil and medium-chain fatty acid oils.

4. The oral cleansing agent according to claim 1, wherein the component (b) is a surfactant with an HLB value of 7 or higher.

5. The oral cleansing agent according to claim 1, wherein component (b) is sucrose stearate or PEG-20 glyceryl triisostearate.

6. The oral cleansing agent according to claim 1, wherein the bodily fluid in the oral cavity is saliva.

7. Furthermore, (c) the oral cleansing agent according to claim 1, comprising an anti-inflammatory agent.

8. The oral cleansing agent according to claim 7, wherein the (c) component is Centella asiatica extract.

9. An oral cleansing agent according to any one of claims 1 to 8, wherein emulsification occurs upon mixing with bodily fluids in the oral cavity, thereby reducing the adhesion of the mixture formed by mixing the oral cleansing agent with bodily fluids to the surface without reducing the cleansing power of component (a).

10. An oral cleansing agent according to any one of claims 1 to 8, in liquid form.

11. The oral cleansing agent according to any one of claims 1 to 8, wherein component (b) is in the form of a solution in which component (a) is dissolved.

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