Composition, method for improving skin condition, method for preventing worsening of skin condition, and composition for improving acne

Abstract

To provide a composition capable of improving skin condition or preventing the worsening of skin condition in relation to skin problems such as acne, and a method of improvement or prevention using the composition. [Solution] A composition containing sulfated polysaccharides derived from Suizenji-nori for improving or preventing the deterioration of skin condition; a method for improving skin condition in healthy skin using the composition (excluding methods for treating humans); a method for preventing the deterioration of skin condition in healthy skin using the composition (excluding methods for treating humans); a composition for improving acne containing sulfated polysaccharides derived from Suizenji-nori.

Description

Technical Field

[0001] The present invention relates to a composition for improving skin condition or preventing deterioration of skin condition, a method for improving skin condition, a method for preventing deterioration of skin condition, and a composition for improving acne.

Background Art

[0002] Skin troubles are caused by external factors (ultraviolet rays, dryness, pollutants, etc.) and internal factors (aging, hormonal imbalance, stress, dietary habits, etc.). These factors reduce various functions of the skin, causing troubles such as acne, inflammation, dryness, and spots, and deteriorating the skin condition. Skin troubles not only impair appearance, but also cause discomfort due to itching and pain, and combined with psychological effects, can lower QOL (Quality of Life), so maintaining healthy skin is an important issue for many people. In order to maintain healthy and beautiful skin, the development of effective skin care products and skin care methods has been ongoing for many years.

[0003] In the skin care market, in order to avoid the adverse effects of synthetic chemicals on the skin, demand for naturally derived ingredients and ingredients derived from organisms other than animals (plants, algae, etc.) is increasing. Examples of naturally derived ingredients and ingredients derived from organisms other than animals include plant-derived raw materials extracted from plant flowers, leaves, roots, fruits, etc., algae-derived raw materials extracted from seaweed and freshwater algae, and microorganism-derived raw materials obtained by fermentation of microorganisms, etc. Sulfated polysaccharides derived from the freshwater blue-green alga Aphanothece sacrum are known to have excellent moisturizing properties and the like, and have been proposed as raw materials for cosmetics (for example, Patent Documents 1 to 2). It has also been reported that the use of this sulfated polysaccharide may alleviate symptoms in patients with atopic dermatitis (see Non-Patent Document 1).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

[0005] [Non-Patent Document 1] Ngatu et al., “Anti-allergic and Profilaggrin(ProFLG)-mRNA expression modulatory effects of sacran,” International Journal of Biological Macromolecules, No. 105, 2017, p1532-1538 [Overview of the Initiative] [Problems that the invention aims to solve]

[0006] Among the skin problems mentioned above, acne (acne vulgaris) is a skin disease that can occur at a wide range of ages, from adolescence to young adulthood, and is often accompanied by itching and pain, causing significant discomfort. Furthermore, acne often leaves scars, causing appearance and psychological stress, and significantly impacting quality of life, thus requiring appropriate treatment. However, there are still few natural ingredients that are effective against acne, and further development is desired.

[0007] The present invention has been made in view of the above problems, and aims to provide a composition containing naturally derived active ingredients that can improve skin condition or prevent the worsening of skin condition in the event of acne and other skin problems, and a method for improvement or prevention using said composition. [Means for solving the problem]

[0008] The inventors of this invention conducted intensive research to solve the above problems and, as a result, novelly discovered that sulfated polysaccharides derived from Suizenji Nori improve skin condition or prevent the worsening of skin condition by improving acne, thus completing the present invention.

[0009] In other words, the present invention provides the following invention. (1) A composition containing sulfated polysaccharides derived from Suizenji Nori, for improving skin condition or preventing deterioration of skin condition. (2) The composition of (1) wherein the improvement in skin condition is one or more selected from the group consisting of improvement of acne, suppression of skin itchiness, improvement of skin texture, and improvement of skin smoothness. (3) The composition of (1) above, wherein the prevention of worsening of skin condition is the prevention of rough skin. (4) A method for improving the condition of healthy skin using the composition of (1) above (excluding methods for treating human beings). (5) A method for preventing deterioration of the condition of healthy skin using the composition of (1) above (excluding methods for treating humans). (6) A composition for improving acne, containing sulfated polysaccharides derived from Suizenji Nori. [Effects of the Invention]

[0010] According to the present invention, acne can be improved. In addition, it is possible to obtain an effect of suppressing itching associated with acne, an effect of improving the skin condition in which the texture and smoothness have deteriorated due to acne, and an effect of preventing skin roughness associated with acne, making it possible to tighten and improve the health of the skin. Furthermore, since Suizenji-nori-derived sulfated polysaccharides are derived from algae, they can be used safely and securely compared to synthetic ingredients derived from petroleum raw materials. In addition, Suizenji-nori-derived sulfated polysaccharides themselves are expected to have moisturizing effects, so they can be used not only as an acne treatment agent but also to improve various skin functions and skin conditions. [Modes for carrying out the invention]

[0011] The present invention will be described in more detail below. However, the present invention is not limited to the embodiments shown below. In this specification, unless otherwise specified, "parts" and "%" mean "parts by mass" and "% by mass," respectively. In this specification, unless otherwise specified, "XX or greater and YY or less" or "XX to YY" means a numerical range including the lower and upper limits which are the endpoints. When a numerical range is described in steps, the upper and lower limits of each numerical range can be combined in any way.

[0012] <Compositions for improving skin condition; Compositions for preventing deterioration of skin condition> The composition for improving skin condition and the composition for preventing deterioration of skin condition (hereinafter sometimes collectively referred to as "the composition") of the present invention contains sulfated polysaccharides derived from Suizenji-nori and is an agent (skin condition improving agent or skin condition deterioration prevention agent) that has the effect of improving skin condition and / or preventing deterioration of skin condition. In the above composition, sulfated polysaccharides derived from Suizenji-nori are contained as an active ingredient.

[0013] The skin condition improvement effect refers to the effect of improving or enhancing one or more properties of the skin. In other words, it can be said to be an effect of improving skin problems. Examples of skin problems include acne (acne vulgaris; including pimples), itchy skin, redness of the skin, excessive sebum secretion on the skin surface, and skin texture and smoothness worsened by acne, etc. By improving these skin problems, the composition of the present invention provides the effect of conditioning troubled skin and tightening troubled skin. Furthermore, the effect of preventing deterioration of skin condition refers to the effect of preventing the deterioration of one or more skin properties. More specifically, deterioration of skin properties includes the occurrence of rough skin and acne. By preventing the deterioration of these skin conditions, the composition of the present invention provides the effect of keeping the skin healthy.

[0014] (Sulfated polysaccharides derived from Suizenji-nori) The sulfated polysaccharide derived from Aphanothece sacrum (hereinafter sometimes simply referred to as "sulfated polysaccharide" or "polysaccharide") is a type of sulfated polysaccharide derived from the freshwater cyanobacterium Aphanothece sacrum obtained naturally or by aquaculture (cultivation), and generally has an average molecular weight of 2,000,000 or more. Specifically, it has a repeating structure of sugar chain units in which a sugar structure having a hexose structure and a sugar structure having a pentose structure are linked in a linear or branched form via α-glycosidic bonds or β-glycosidic bonds, the sugar chain unit contains a sulfated sugar as the sugar structure, and in the sugar chain unit, 2.7 or more hydroxyl groups per 100 hydroxyl groups are sulfated, or it is a sugar derivative in which elemental sulfur accounts for 1.5% by mass or more of all elements.

[0015] Specific examples of the sulfated polysaccharide include sulfated muramic acid and sulfated N-acetylmuramic acid.

[0016] The sulfated polysaccharide contains at least glucose, galactose, mannose, galactosamine, xylose, arabinose, glucuronic acid, galacturonic acid, fucose, and rhamnose, and a functional group selected from the functional group group including at least a sulfate group, a lactic acid group, and a methyl group may be bonded to any bonding position in these sugar structures. The sulfate group, which is a characteristic of the sulfated polysaccharide derived from Aphanothece sacrum, is preferably contained in the sulfated polysaccharide in an amount of 3 to 20% by mass, more preferably 5 to 15% by mass, and even more preferably 8 to 12% by mass.

[0017] A part of the sugar structure constituting the sulfated polysaccharide may further be bonded to a peptide or a lipid.

[0018] The molar ratio of the main sugar structures constituting the sulfated polysaccharide may be arabinose 1.1 : fucose 3.7 : rhamnose 15.4 : xylose 17.0 : mannose 10.5 : galactose 12.3 : galacturonic acid 4.6 : glucuronic acid 4.7 : glucose 28.8 : galactosamine 2.03. In addition, the number of types of sugar structures (monosaccharides) constituting the sulfated polysaccharide may be 5 or more, 7 or more, 8 or more, or 10 or more.

[0019] The average molecular weight of the sulfated polysaccharide is, for example, 500,000 or more, 800,000 or more, 1,000,000 or more, 2,000,000 or more, 5,000,000 or more, 10,000,000 or more, 20,000,000 or more, etc., and is 30,000,000 or less, 28,000,000 or less, 25,000,000 or less, 22,000,000 or less, etc. A non-contradictory combination thereof is also acceptable. For example, it may be 1,000,000 to 30,000,000, 5,000,000 to 28,000,000, 10,000,000 to 25,000,000, 20,000,000 to 22,000,000, etc.

[0020] The sulfated polysaccharide may be one extracted, isolated and purified from Aphanothece sacrum. The method for extracting the sugar derivative from Suizenji-nori is not particularly limited, and conventional methods such as those described in Patent Document 2 can be used. Specifically, for example, the following can be used: A suitable amount of Suizenji-nori is frozen and thawed, then washed with water to remove water-soluble pigments, and then lipid-soluble pigments are removed by stirring with an organic solvent such as ethanol for 24 hours. After separating the organic solvent from the Suizenji-nori from which the pigments have been removed, the solvent is dissolved in an aqueous solution of sodium hydroxide, for example, at 40 to 80°C, while stirring for 5 to 12 hours. The aqueous solution of the sugar derivative extracted by this operation is neutralized with concentrated hydrochloric acid, for example. Here, desalting may or may not be performed by immersing in 60 to 80% isopropyl alcohol, for example. After that, the solution is poured into 100% isopropanol while stirring to precipitate a gel-like sugar derivative, and then dried with hot air. Drying with hot air may be done at 85 to 100°C for 6 to 24 hours, for example. The extracted and precipitated sugar derivatives may be purified by centrifugation, filtration, alcohol washing, etc.

[0021] Sulfated polysaccharides may be commercially available products, such as "Sacran" (registered trademark) manufactured by Green Science Material (GSM) and "Sacranex" (registered trademark) manufactured by the DIC Group.

[0022] Furthermore, the sulfated polysaccharides may be present in a form that is included in the crushed dried product of Suizenji-nori (hereinafter referred to as "crushed dried product of Suizenji-nori"), insofar as they achieve the effects of the present invention. Therefore, the present invention can also provide a composition containing crushed dried Suizenji-nori containing sulfated polysaccharides as an active ingredient. The crushed dried Suizenji Nori containing the sugar derivative may be, for example, a crushed freeze-dried Suizenji Nori containing the sugar derivative, a crushed sun-dried Suizenji Nori containing the sugar derivative, or a crushed hot-air dried Suizenji Nori containing the sugar derivative, and any one of these may be used, or a combination of several may be used. Crushed dried Suizenji-nori containing sulfated polysaccharides can all be prepared by conventional methods. For example, crushed freeze-dried Suizenji-nori containing the aforementioned sugar derivatives can be prepared by freezing Suizenji-nori containing water in a low-temperature freezer, removing the water contained within the algae by vacuum freeze-drying to obtain freeze-dried Suizenji-nori, and then crushing it (for example, by grinding it with a mortar and pestle, or by grinding it into a powder using a pulverizer). After that, it may be suspended in an appropriate solvent or solution.

[0023] Furthermore, the sulfated polysaccharides may be present in an extract of Suizenji-nori (hereinafter referred to as "Suizenji-nori extract") insofar as they achieve the effects of the present invention. Therefore, the present invention can also provide a composition containing a Suizenji Nori extract containing sulfated polysaccharides as an active ingredient. Suizenji-nori extract containing sulfated polysaccharides can be prepared, for example, by the method described above.

[0024] The composition of the present invention improves skin condition or prevents the deterioration of skin condition. The target skin cells may be cells present in the epidermis or cells present in the dermis. Examples of cells present in the epidermis include keratinocytes, granular cells, spinous cells, Langerhans cells, and basal cells. Examples of cells present in the dermis include fibroblasts and pigment cells (melanocytes). In addition to the above, sebaceous glands, pores, and hair follicles can also affect skin condition and acne, so the composition of the present invention may also act on sebaceous gland-related cells such as sebaceous gland cells, hair follicle-related cells such as hair matrix cells, and hair root / hair-related cells such as dermal papilla cells. Furthermore, since commensal bacteria on the skin also affect skin condition, sebum secretion, and decomposition, the composition may also act on cells related to commensal bacteria.

[0025] The composition of the present invention may be used as is, but may also be used as a cosmetic, topical skin preparation, quasi-drug, pharmaceutical, etc., for the purpose of obtaining an effect of improving skin condition and / or preventing the deterioration of skin condition, or may be incorporated into cosmetics, topical skin preparations, quasi-drugs, or pharmaceuticals. Among these, it is preferable to use it in the form of a cosmetic or topical skin preparation.

[0026] • Cosmetics or topical skin preparations When the composition of the present invention is used in cosmetics or topical skin preparations, the cosmetics or topical skin preparations can be manufactured by conventional methods (for example, methods described in the Japanese Pharmacopoeia) using the composition itself containing the sulfated polysaccharide derived from Suizenji Nori, or, if applicable, by further mixing it with other components.

[0027] Other components include pharmaceutically acceptable carriers. A "pharmaceutically acceptable carrier" means a carrier that does not inhibit the physiological activity of the active ingredient and does not exhibit substantial toxicity to the target of use. "Substantial toxicity" means that the ingredient does not exhibit toxicity to the target of use at the amount normally used. Pharmaceutically acceptable carriers are not particularly limited and include oily components, humectants, texture enhancers, surfactants, various polymers, thickeners, gelling agents, antioxidants, preservatives, antibacterial agents, chelating agents, pH adjusters, acids and alkalis, powders, UV absorbers, various active ingredients (whitening agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, anti-aging agents, etc.), antipruritics, vitamins and their derivatives, hormones, various extracts, fragrances, colorants (pigments, colorants, dyes, pigments), etc.

[0028] Oily components include higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachidodecanol, behenyl alcohol, jojoba alcohol, chimyl alcohol, cerachidodecanol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimergol; aralkyl alcohols and their derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, and isostearic acid. , behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanic acid, long-chain branched fatty acids, dimer acids, hydrogenated dimer acids and other higher fatty acids, and their aluminum salts, calcium salts, magnesium salts, zinc salts, sodium salts, potassium salts and other metal soaps, and amine salts such as ethanolamine salts, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid ion Carbides such as soparaffins, light liquid isoparaffins, α-olefin oligomers, polyisobutenes, hydrogenated polyisobutenes, polybutenes, squalanes, olive-derived squalanes, squalenes, petrolatum, and solid paraffins; waxes such as candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymers; coconut oil, Vegetable oils such as palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, peach kernel oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, etc.; animal fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil, etc.Animal waxes such as whale wax, lanolin, and orange roughy oil; lanolin compounds such as liquid lanolin, reduced lanolin, adsorbed and purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acids, hard lanolin fatty acids, lanolin alcohol, lanolin acetate alcohol, and (cetyl lanolyl) acetate; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol Phosphatidylinositol, sphingomyelin and other sphingophospholipids, phosphatidic acid, lysolecithin and other phospholipids; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid and other sterols; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate Cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), N-lauroyl sarcosinate isopropyl Sterol esters such as acyl sarcosinate alkyl esters, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid-cholesterol complexes and phospholipid-phytosterol complexes;Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palimitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, ricinoleic acid Monoalcoholic carboxylic acid esters such as octyldodecyl, octyldodecyl lanolate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolate, triethyl citrate; oxyacid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate;Glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, caprylic / capric triglyceride, caprylic / capric / myristic / stearic triglyceride, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eicosanedioate behenate, glyceryl tetradecanediol / eicosanedioate, polyglyceryl-10 tetradecanediol / eicosanedioate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, 3-methyl-1,5-pentanediol dineopentanoate Polyhydric alcohol fatty acid esters such as 2,4-diethyl-1,5-pentanediol dineopentanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearate / sebacate), pentaerythrityl triethylhexanoate, dipentaerythrityl (hydroxystearate / stearate / rosinate), diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, polyglyceryl-8 dec(erucate / isostearate / ricinoleate), diglyceryl oligoester (hexyldecanoate / sebacate), glycol distearate (ethylene glycol distearate);Diisopropyl dimer dilinoleate, diisostearyl dimer dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, (phytosteryl / behenyl) dimer dilinoleate, (phytosteryl / isostearyl / cetyl / stearyl / behenyl) dimer dilinoleate, dimer dilinoleyl bis(phytosteryl / behenyl / isostearyl) dimer dilinoleate, dimer dilinoleyl diisostearate, hydrogenated rosin condensate of dimer dilinoleate, hydrogenated castor oil dimer dilinoleate, hydroxyalkylated Dimer acid or dimer ol derivatives such as imergerinoleyl ether; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA);Dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, stearoxypropyl dimethylamine, (aminoethylaminopropyl methicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cationic-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerides Silicones such as phosphorus-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphate-modified silicones, sulfuric acid-modified silicones, alkyl-modified silicones, fatty acid-modified silicones, alkyl ether-modified silicones, amino acid-modified silicones, peptide-modified silicones, fluorine-modified silicones, cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, and polysiloxane-oxyalkylene copolymers are preferred. Fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether are also preferred.

[0029] As humectants and texture enhancers, these include: glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol-propylene glycol copolymers and other polyols and their polymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, Natural sugars and their derivatives such as raffinose, gluconic acid, glucuronic acid, β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, kerato sulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fucoidan; tuberose polysaccharide, etc. Derived polysaccharides; organic acids such as citric acid, tartaric acid, and lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salt and other salts; amino acids such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, and taurine and their salts;Protein peptides and their derivatives such as collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degraded peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degraded peptides, keratin-degraded peptides, hydrolyzed keratin, conchiolin-degraded peptides, hydrolyzed conchiolin, silk protein-degraded peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein-degraded peptides, wheat protein-degraded peptides, hydrolyzed wheat protein, casein-degraded peptides, acylated peptides, etc.; palmitoyl oligopeptides, palmitoyl pentapeptides, palmitoyl tetrapeptides, etc. Preferred ingredients include ceramides; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesamin glycosides, glutathione, albumin, whey; choline chloride, phosphorylcholine; placental extract, aerlastin, collagen, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rose extract, yarrow extract, eucalyptus extract, sweet clover extract, and other animal and plant extracts; natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudoceramides, sphingoglycolipids, ceramides, and ceramide-containing extracts; and other ceramides.

[0030] Preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymeric surfactants. There are no particular restrictions on the HLB of the surfactant; those with a low HLB of around 1 to a high HLB of around 20 can be used, and it is also preferable to combine those with low and high HLB values. Examples of preferred surfactants include anionic surfactants such as fatty acid salts like potassium laurate and potassium myristate; alkyl sulfate esters such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methylalanine, sodium lauroyl sarcosinate, triethanolamine lauroyl sarcosinate, and sodium lauroyl glutamate methylalanine; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, and palmitoyl glutamate. Acyl amino acid salts such as ditriethanolamine aspartate and triethanolamine cocoyl alanine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinate ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty acid amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; alkylbenzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and sodium dioctyl sulfosuccinate; alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate sodium, and sodium lauryl polypropylene glycol sulfosuccinate sodium;Alkylbenzenesulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalene sulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, and sodium monooleth phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphates; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicones, phosphate-modified silicones, and sulfate-modified silicones; nonionic surfactants include laureth (polyoxyethylene lauryl ether) and ceteth (polyoxyethylene lauryl ether). Polyoxyethylene alkyl ethers of various polyoxyethylene addition numbers, such as polyoxyethylene cetyl ethers, steareths (polyoxyethylene stearyl ethers), beheneths (polyoxyethylene behenyl ethers), isosteareths (polyoxyethylene isostearyl ethers), and octyldodeceths (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkylphenyl ethers; castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, and polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin;Polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl. ) Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, coconut oil fatty acid glyceryl, monocottonseed oil fatty acid glycerin, monoerucate glycerin, sesquioleate glycerin, α,α'-oleate pyroglutamate glycerin, monostearate glycerin malic acid and other glycerin fatty acid partial esters; polyglyceryl-2, 3, 4, 5, 6, 8 stearate , same 10, polyglyceryl-6 distearate, same 10, polyglyceryl-2 tristearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 isostearate, same 3, same 4, same 5, same 6, same 8, same 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), same 3, same 10, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, same 3, Polyglycerin fatty acid esters such as Polyglyceryl-6 dioleate, Polyglyceryl-2 trioleate, Polyglyceryl-10 decaoleate; Ethylene glycol monofatty acid esters such as Ethylene glycol monostearate; Propylene glycol monofatty acid esters such as Propylene glycol monostearate; Pentaerythritol partial fatty acid ester; Sorbitol partial fatty acid ester; Maltitol partial fatty acid ester; Maltitol ether;Sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, sorbitan penta-2-ethylhexyl diglycerol sorbitan, sorbitan tetra-2-ethylhexyl diglycerol sorbitan; sugar derivative partial esters such as sucrose fatty acid esters, methyl glucoside fatty acid esters, and trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycerides Coside; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acid mono and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene glycerin fats such as polyoxyethylene monooleate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate, and other polyoxyethylene monooleates. Fatty acid esters; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chymyl alcohol, cerakyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); lauramine oxide nonionic silicone surfactants such as: alkyldimethylamine oxides such as cocamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, sugar-modified silicones, etc.; cationic surfactants such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium Alkyltrimethylammonium chlorides such as nium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amide amines and their salts such as stearamidopropyldimethylamine and stearamidoethyldiethylamine; alkyl etheramines and their salts or quaternary salts such as stearoxypropyldimethylamine; fatty acid amide-type quaternary ammonium salts such as ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium and ethyl sulfate lanolin fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and their salts or quaternary salts; alkylamine salts; fatty acid amide guanidium salts; alkyl etheramine mononium salts; alkyl trialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmolyphonium salts; polyamine fatty acid derivatives;Silicone-based cationic surfactants such as aminopropyl dimethicone and amodimethicone (amino-modified silicones), cationic-modified silicones, cationic and polyether-modified silicones, amino-modified and polyether-modified silicones, etc.; amphoteric surfactants such as N-alkyl-N,N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N,N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyl sulfobetaines such as alkyldimethyl taurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; sphingolin lipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin; Phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants; and polymeric surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymer, and 2-methachloroyloxyethyl phosphorylcholine / stearyl methacrylate copolymer; and various silicone-based surfactants are preferred.

[0031] Various polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed gum, carrageenan, galactan, gum arabic, tara gum, tamarind, fercerelan, karaya gum, okra gum, tragacanth gum, pectin, pectic acid and its salts, alginic acid and its salts, mannan; starches from rice, corn, potato, wheat, etc.; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin, chitosa Cellulose, agar, cassia seed extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder, and other cellulose and its derivatives; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch, and other derivatives Starch derivatives such as corn starch aluminum octenyl succinate, hydroxypropyltrimonium chloride, and octenyl succinate; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpyridone-vinyl alcohol copolymer, and polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, and polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer and (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, and (alkyl acrylate / diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate and maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyesters and water-dispersible polyesters.Polyacrylamide; polyacrylic acid ester copolymers such as ethyl polyacrylate, carboxyvinyl polymers, salts such as polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymers; acrylic acid / alkyl methacrylate copolymers; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymers such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymers such as polyquaternium-22, acrylic acid / diallyldimethylammonium chloride / acrylamide copolymers such as polyquaternium-39, acrylic acid / cationized methacrylic acid ester copolymers, acrylic acid / cationized methacrylamide copolymers, acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymers such as polyquaternium-47, choline methacrylate ester polymers; cationized oligosaccharides, cationized dextran, cationized guar hydroxypropyltrimonium chloride, etc. Polysaccharides; polyethyleneimines; cationic polymers; copolymers of 2-methacryloyloxyethyl phosphorylcholine polymers such as polyquaternium-51 and butyl methacrylate copolymers; polymer emulsions such as acrylic resin emulsions, ethyl polyacrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; anhydrous silicic acid, fuzzy silica (ultrafine particle anhydrous silicic acid), magnesium aluminum silicate, magnesium sodium silicate, metal soaps, dialkyl phosphate metal salts, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters are among the preferred materials.

[0032] Preferred antioxidants include alpha-lipoic acid, salts of alpha-lipoic acid, and derivatives of alpha-lipoic acid; tocopherol derivatives such as tocopherol (vitamin E), tocotrienol, and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine ​​hydrochloride. Preferred reducing agents include thioglycolic acid, cysteine, and cysteamine. Preferred oxidizing agents include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

[0033] As preservatives and antibacterial agents, hydroxybenzoic acids and their salts or esters such as methylparaben, ethylparaben, propylparaben, and butylparaben; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-diols such as 1,2-pentanediol and 1,2-hexanediol; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan; acid ammonium compounds Preferred materials include dihydrogen ammonium compounds, quaternary ammonium salts; trichlorocarbanides, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenols, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol, and other phenols; phenylethyl alcohol, photosensitizers, antibacterial zeolites, and silver ions.

[0034] Preferred chelating agents include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and their sodium salts; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid.

[0035] Preferred pH adjusters and acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

[0036] Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium dioxide, fine and ultrafine titanium dioxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fuzzy silica (ultrafine anhydrous silicic acid), and titanium mica. Preferred materials include inorganic powders of various sizes and shapes such as fish scale foil, boron nitride, photochromic pigments, synthetic fluorphlogopite, fine particle composite powders, gold, aluminum, and inorganic powders that have been hydrophobized or hydrophilized by treating them with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silanes or titanium coupling agents; organic powders of various sizes and shapes such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminated powder, polyethylene terephthalate-aluminum-epoxy laminated powder, urethane powder, silicone powder, Teflon® powder, and other organic powders and surface-treated powders, as well as organic-inorganic composite powders.Preferred inorganic salts include sodium chloride-containing salts such as table salt, regular salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate; and sodium phosphates such as 1Na, 2Na, and 3Na phosphates, potassium phosphates, calcium phosphates, and magnesium phosphates.

[0037] UV absorbers include benzoic acid-based UV absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerol ester, N,N-dipropoxypara-aminobenzoate ethyl ester, N,N-diethoxypara-aminobenzoate ethyl ester, N,N-dimethylpara-aminobenzoate ethyl ester, N,N-dimethylpara-aminobenzoate butyl ester, and N,N-dimethylpara-aminobenzoate ethyl ester; anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid-based UV absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanolphenyl salicylate; and octyl cinnamate. Cinnamic acid-based UV absorbers such as ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy cinnamate, 2-ethylhexyl-p-methoxy cinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxy cinnamate (cinoxate), cyclohexyl-p-methoxy cinnamate, ethyl-α-cyano-β-phenyl cinnamate, 2-ethylhexyl-α-cyano-β-phenyl cinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy cinnamate, ferulic acid and its derivatives;Benzophenone-based UV absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenylbenzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydro Xy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzarazine; dianisioylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butyl methoxydibenzoylmethane; octyltriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanic acid; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole; Preferred materials include benzotriazole (nyl), 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, and other hydantoin derivatives, phenylbenzimidazol sulfonic acid, terephthalylidene dicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.

[0038] Preferred whitening agents include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate, ascorbic acid fatty acid esters such as tetraisopalmitic ascorbic acid, alkyl ascorbic acid ethers such as ethyl ascorbic acid, ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, willow extract, saxifrage extract, and other plant extracts.

[0039] Preferred anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract.

[0040] Preferred hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, Capsicum tincture, Ginger tincture, Ginger extract, and Cantharis tincture; capsaicin, nonylic acid valenylamide, gingerol, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E and derivatives such as tocopherol nicotinate and tocopherol acetate; γ-oryzanol, nicotinic acid and derivatives such as nicotinamide, benzyl nicotinate, inositol hexanicotinate, and nicotinic alcohol; allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmamanol and its glycosides; and minoxidil.

[0041] Other medicinal agents such as anti-aging agents, anti-wrinkle agents, firming agents, cooling agents, warming agents, wound healing promoters, irritation relievers, analgesics, and cell activators include retinols, retinoic acids, retinoic acid tocopheryl; lactic acid, glycolic acid, gluconic acid, fruit acids, salicylic acid and its glycosides and esters and their derivatives; hydroxycapric acid, long-chain α-hydroxy fatty acids, long-chain α-hydroxy fatty acid cholesteryl and other α- or β-hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and their derivatives; coenzyme Q10, carotene, lycopene, astaxanthin, lutein, etc. Preferred materials include antioxidants and free radical scavengers; catechins; flavonoids such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannins, sesamin, protoanthocyanidins, chlorogenic acid, and apple polyphenols; rutin and glycoside derivatives; hesperidin and glycoside derivatives; lignan glycosides; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; lactoferrin; gingerol; fragrance substances and their derivatives such as menthol, camphor, and cedrol; capsaicin, vanillin, and their derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances with cyclodextrins.

[0042] Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance-P inhibitors. Examples of exfoliating and dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, and pyridoxine. Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of cooling agents include menthol and methyl salicylate. Examples of astringent agents include citric acid, tartaric acid, lactic acid, potassium aluminum sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease. Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

[0043] Vitamins and their derivatives include vitamin A compounds such as retinol, retinyl acetate, and retinyl palmitate; vitamin B compounds such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acid compounds, nicotinic acid compounds such as nicotinamide and benzyl nicotinate, and choline compounds; vitamin C compounds such as ascorbic acid and its sodium salts; vitamin D; vitamin E compounds such as α, β, γ, and δ-tocopherols; other vitamins such as pantothenic acid and biotin; and ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt. Preferred materials include ascorbic acid phosphate salts, ascorbic acid fatty acid esters such as tetraisopalmitic ascorbate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, alkyl ascorbic acid ethers such as ethyl ascorbate, ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate esters, tocotrienols, and various other vitamin derivatives.

[0044] Preferred hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, and prednisone.

[0045] Various extracts from plants, animals, and microorganisms include iris extract, angelica extract, Thujopsis dolabrata extract, asparagus extract, avocado extract, Hydrangea macrophylla extract, almond extract, Althaea extract, Arnica extract, apricot extract, apricot kernel extract, Ginkgo biloba extract, Inca extract, fennel extract, turmeric extract, oolong tea extract, bearberry extract, rosehip extract, Echinacea leaf extract, Enmeisou extract, Scutellaria baicalensis extract, Phellodendron amurense extract, Coptis japonica extract, barley extract, Panax ginseng extract, St. John's wort extract, and Lamium album. Grass extract, Ononis extract, Nasturtium officinale extract, Orange extract, Dried seawater, Seaweed extract, Persimmon leaf extract, Arctium moniliforme extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria lobata extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Artemisia capillaris extract, Oat extract, Chloranthus erythrosora extract, Licorice extract, Oil-soluble licorice extract, Kiwi extract, Kelpodium extract, Wood ear mushroom extract, Cinchona extract, Cucumber extract, Paulownia leaf extract, Guanosine, Guava extract, Sophora flavescens extract, Gardenia extract, Sasa veitchii extract Sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Geranium thunbergii extract, black tea extract, yeast extract, Magnolia bark extract, coffee extract, burdock extract, rice extract, rice fermentation extract, rice bran fermentation extract, rice germ oil, comfrey extract, collagen, lingonberry extract, Asarum sieboldii extract, Bupleurum chinense extract, umbilical cord extract, saffron extract, sage extract, soapwort extract, bamboo extract, hawthorn extract, sunflower extract Sodium, Japanese pepper extract, shiitake mushroom extract, rehmannia extract, lithospermum extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony extract, ginger extract, calamus root extract, birch extract, white fungus extract, horsetail extract, stevia extract, stevia ferment, iris extract, ivy extract, hawthorn extract, elderflower extract, yarrow extract, peppermint extract, sage extract, mallow extract, chuanxiong extract, swertia japonica extract, mulberry bark extract, rhubarb extract,Soybean extract, jujube extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, cogongrass extract, citrus peel extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, Ophiopogon extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, Isodon japonicus extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur extract, Poria cocos extract, butcher's broom extract, grape extract Examples of extracts include grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, cypress extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, lemon balm extract, seaweed extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, reishi mushroom extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract.

[0046] The fragrance ingredients include acetylcedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, iso-esuper, isobutylquinoline, iris oil, ylone, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragol, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carbone, camphor, canone, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styraryl acetate, cedyl acetate, terepinel acetate, and pt-butylcyclohexyl acetate. Lu, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanol, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-Nonadienol, Nonalactone, Patchouli Alcohol, Vanilla Absolute, Vanillin, Basil Oil, Patchouli Oil, Hydroxycitronellal, α-Pinene, Piperitone, Phenethyl Alcohol, Phenylacetaldehyde, Petitgrain Oil, Hexyl Cinnamaldehyde, cis-3-Hexenol, Peruvian Balsam, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Benzyl Benzoate Preferred examples include synthetic and natural fragrances such as benzoate, borneol, myrrhizinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, liral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances.

[0047] As pigments, colorants, dyes, and dyes, they include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, and Red. Color No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 22 No. 5, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red Color No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow Legal dyes such as No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Yellow No. 5; Acid Other acidic dyes such as Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p- Nitro dyes such as phenylenediamine, HC Blue 2, and Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and lower titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; titanium dioxide coated mica, titanium dioxide coated oxy Pearl pigments such as bismuth chloride, titanium dioxide-coated talc, colored titanium dioxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; surface-treated inorganic and metal powder pigments; Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404, Red 3, Red 104, Red 106, Red 22 Organic pigments such as zirconium, barium, or aluminum lake, including No. 7, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, Blue No. 1, etc.; surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin, and other naphthoquinones, bixy Natural pigments and dyes such as flavonoids, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidative dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-,m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and their salts; auto-oxidative dyes such as indoline; and dihydroxyacetone are preferred.

[0048] Other ingredients may include those listed in the Cosmetic Standards, Cosmetic Ingredient Formulation Standards, Japan Cosmetic Industry Association Ingredient Labeling Name List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Raw Material Standards, Japanese Pharmacopoeia, Pharmaceutical Additives Standards, and the Food Additives Compendium, as well as known cosmetic ingredients and pharmaceutical ingredients. Such ingredients may be included in cosmetics or topical skin preparations to the extent that the effects expected from Suizenji-nori-derived sulfated polysaccharides (specifically, skin condition improvement effects and / or skin condition deterioration prevention effects) can be obtained.

[0049] Cosmetics or topical skin preparations may contain an effective amount of sulfated polysaccharides derived from Suizenji-nori. "Effective amount" refers to the amount of Suizenji-nori-derived sulfated polysaccharides that is effective in exerting the expected effects (specifically, skin condition improvement and / or skin condition deterioration prevention effects). The effective amount may vary depending on the age, sex, and weight of the user. In cosmetics or topical skin preparations, the effective amount of sulfated polysaccharides derived from Suizenji-nori is, for example, 0.005% by mass or more as the content of sulfated polysaccharides derived from Suizenji-nori in the cosmetic or topical skin preparation, for example, 0.005 to 1.000% by mass, preferably 0.010% to 1.000% by mass, more preferably 0.030% to 0.800% by mass, even more preferably 0.050% to 0.500% by mass, particularly preferably 0.060% to 0.300% by mass, quite preferably 0.070% to 0.250% by mass, very preferably 0.075% to 0.200% by mass, and most preferably 0.080% to 0.150% by mass. Furthermore, the sulfated polysaccharides derived from Suizenji-nori in cosmetics or topical skin preparations may be present in an effective amount on their own, or in combination with other active ingredients to determine the effective amount.

[0050] The dosage form of cosmetics or topical skin preparations is not particularly limited, but examples include ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. Cosmetics or topical skin preparations may be pharmaceuticals, quasi-drugs, or cosmetics.

[0051] While there are no particular limitations on the uses of cosmetics, examples include basic cosmetics such as lotions, emulsions, creams, ointments, oils, packs, and balms; skin cleansing products such as facial cleansers and body washes; massage cosmetics such as massage agents; cleansing cosmetics such as cleansing agents; hair removal cosmetics such as depilatory agents and hair removal agents; shaving cosmetics such as shaving creams, aftershave lotions, pre-shave lotions, and shaving creams; makeup cosmetics such as foundations, lipsticks, blushes, eyeshadows, eyeliners, and mascaras; and other topical cosmetics such as perfumes, nail care products, nail enamels, nail enamel removers, poultices, plasters, tapes, sheets, patches, and aerosols. Cosmetics or topical skin preparations may also be preparations for the scalp and / or hair. Examples of preparations for the scalp and / or hair include shampoos, conditioners, hair treatments, pre-hair treatments, permanent solutions, hair dyes, hair styling products, hair tonics, hair growth and nourishing products, scalp poultices, scalp plasters, scalp tapes, scalp sheets, scalp patches, hair or scalp aerosols, etc. Furthermore, the cosmetic or topical skin preparation may also be a bath additive used by adding it to bathwater. The cosmetic or topical skin preparation of the present invention can also be used as an antiperspirant, deodorant, odor eliminator, antiperspirant, sanitary product, sanitary cotton, wet wipes, toothpaste, mouth freshener, gargle, etc.

[0052] <Methods to improve skin condition> The present invention relates to a method for improving the condition of the skin (hereinafter sometimes referred to as the "improvement method"), which involves applying the above-described composition to healthy skin. The method is a non-therapeutic method, excluding methods for treating humans, and is preferably applied to the skin of a healthy person, and more preferably used for cosmetic purposes on the skin of a healthy person.

[0053] The method of applying the composition of the present invention, or cosmetics or topical skin preparations formulated from the composition, to the skin surface is not particularly limited and can be applied by rubbing, spraying, or patching to the target area, but rubbing is preferred. Application may be done with fingers, or using application materials such as cotton, gauze, puffs, tissue paper, or sprays. The detailed usage and dosage are not particularly limited and can be determined as appropriate considering the effective amount, but for example, it can be 1 to 5 times, 1 to 3 times, 1 to 2 times, or once per day.

[0054] <How to prevent skin condition from worsening> The present invention provides a method for preventing deterioration of skin condition, which involves applying the above-described composition to healthy skin. This method is a non-therapeutic method, excluding methods for treating humans, and is preferably applied to the skin of a healthy person, and more preferably used for cosmetic purposes on the skin of a healthy person. The method of application to the skin is not particularly limited and can be used in the manner described in the improved method above.

[0055] <Composition for improving acne> The acne-improving composition of the present invention contains sulfated polysaccharides derived from Suizenji Nori, and improves acne (including acne vulgaris; pimples), a skin problem, and conditions the skin to keep it healthy. The sulfated polysaccharides derived from Suizenji Nori contained in the acne-improving composition, and other components that the acne-improving composition may contain, are as described above. The acne-improving composition is preferably applied to healthy skin, preferably to the skin of a healthy person, and more preferably used for cosmetic purposes on the skin of a healthy person. The method of application to the skin is not particularly limited and can be used in the manner described above for improvement.

[0056] In another aspect, the present invention provides a skincare composition containing sulfated polysaccharides derived from Suizenji-nori. In another aspect, the present invention provides sulfated polysaccharides derived from Suizenji-nori for improving or preventing the deterioration of skin condition, and the use of sulfated polysaccharides derived from Suizenji-nori for improving or preventing the deterioration of skin condition. The effects of improving skin condition and preventing the deterioration of skin condition are as described above. [Examples]

[0057] The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

[0058] [Manufacturing example] The compositions (creams) for Production Example 1 and Comparative Production Example 1 were prepared using the following procedure. First, component A, as shown in Table 1, was dispersed at room temperature and then heated to 80°C and mixed and dissolved. In a separate container, component B was heated to 80°C and mixed and dissolved. Next, component A was gradually added to component B in several batches while stirring with a homomixer at 80°C. After that, the mixture was emulsified by stirring with a homomixer at 7000 rpm for 3 minutes. Then, component C was added while stirring at 80 rpm with the stirring blade changed to a U-shaped blade, and the mixture was air-cooled to below 40°C to obtain the compositions (creams) shown in Table 1. The content of each component listed in Table 1 is in parts by mass.

[0059] [Table 1]

[0060] [Experimental Example 1] The effects of sulfated polysaccharides derived from Suizenji-nori on the skin were evaluated using the following procedure. The study involved 30 volunteers aged 15 to 42 years (average 21.1 ± 5.0 years). The subjects had combination or oily skin (U-zone sebum >130 μg / cm³). 2 The subjects were defined as individuals who reported having mild to moderate acne (approximately 2-3 stages on the IGA scale). The test sample (cream A) was applied to one side of each subject's face, and a placebo (cream B) was applied to the other side of their face. The samples were applied twice daily, morning and evening, for a total of four weeks. Data was collected before the start of the study and after four weeks.

[0061] The area and volume of acne were measured using a Nikon D5600 digital camera (product name, manufactured by Nikon Corporation). High-resolution macro photographs were taken of a 50mm wide x 50mm high area of ​​the cheek, and the area and volume of acne after 4 weeks were calculated using image analysis, with the pre-test values ​​set to 100%.

[0062] [Table 2]

[0063] [Experimental Example 2] The effects of sulfated polysaccharides derived from Suizenji-nori on the skin were evaluated using the following procedure. Similar to Experimental Example 1, acne on the entire cheek was evaluated, and the number and circumference of acne were calculated. The calculated value for Cream A (measured value after 4 weeks divided by the value before the start of the experiment) is set as 100% when the calculated value for Cream B (measured value after 4 weeks divided by the value before the start of the experiment) after 4 weeks is shown in Table 3 as the acne suppression ratio. Furthermore, the amount of sebum on the cheeks was measured using the oil content measuring device "Sebumeter SM 815" (product name, manufactured by Courage+Khazaka). Table 3 shows the sebum secretion suppression ratio of Cream A (measured value after 4 weeks divided by value before the start of the test) compared to the calculated value of Cream B after 4 weeks (measured value after 4 weeks divided by value before the start of the test), which is set to 100%.

[0064] [Table 3]

[0065] In addition, after the trial in Experiment Example 2, the subjects were given a questionnaire on each of the following items using a 4-point scale (1 = strongly disagree, 2 = disagree, 3 = agree, 4 = strongly agree), and their satisfaction level was calculated using the following formula. The satisfaction levels for each item of Cream A and Cream B are shown in Table 4. Satisfaction level (%) = Number of people who answered 3 or 4 / Total number of respondents

[0066] [Table 4]

[0067] [Experimental Example 3] The effects of sulfated polysaccharides derived from Suizenji-nori on the skin were evaluated using the following procedure. The study involved 32 volunteers aged 20 to 61 years (average 39.8 ± 11.6 years). Participants were defined as having sensitive skin and self-reporting moderate to very severe facial eczema (redness grade 2-4 on the Eiben-Nielson light scale). The test sample (cream A) was applied to one side of the subject's face, and a placebo (cream B) was applied to the other side of their face, twice daily, morning and evening, for a total of four weeks. After the trial, participants were given a questionnaire on each of the following items using a 4-point scale (1 = strongly disagree, 2 = disagree, 3 = agree, 4 = strongly agree), and satisfaction levels were calculated using the following formula. Table 4 shows the satisfaction levels for each item of Cream A and Cream B. Satisfaction level (%) = Number of people who answered 3 or 4 / Total number of respondents

[0068] [Table 5]

[0069] From the results above, it was confirmed that the composition according to the present invention reduces the area, volume, number, and circumference of acne, as well as the amount of sebum secreted. Furthermore, an improvement in acne was also observed in a comprehensive questionnaire administered to participating volunteers. Therefore, it has been confirmed that the composition of the present invention can improve acne, prevent and improve the worsening of skin conditions (itching, redness, uneven discoloration, discomfort, dryness), prevent and improve rough skin (decreased texture, decreased smoothness, decreased luster, etc.), and contribute to maintaining healthy skin.

Claims

1. A composition containing sulfated polysaccharides derived from Suizenji-nori, for improving skin condition or preventing deterioration of skin condition.

2. The composition according to claim 1, wherein the improvement in skin condition is one or more selected from the group consisting of improvement of acne, suppression of skin itchiness, improvement of skin texture, and improvement of skin smoothness.

3. The composition according to claim 1, wherein the prevention of worsening skin condition is the prevention of skin roughness.

4. A method for improving the condition of healthy skin using the composition described in claim 1 (excluding methods for treating human beings).

5. A method for preventing deterioration of skin condition in healthy skin using the composition described in claim 1 (excluding methods for treating humans).

6. A composition for improving acne, containing sulfated polysaccharides derived from Suizenji-nori (a type of algae).

Images