Composition containing ceramide-type compounds

Abstract

To provide a stable composition that can form a microsheet structure containing a ceramide-type compound. [Solution] The present invention relates to a composition comprising (a) at least one ceramide-type compound and (b) at least one glycolipid, wherein the amount of (c) oil in the composition is less than 5% by mass, preferably less than 3% by mass, and more preferably less than 1% by mass, based on the total mass of the composition. The composition according to the present invention is stable and can form a microsheet structure containing (a) the ceramide-type compound.

Description

[Technical Field]

[0001] The present invention relates to a composition comprising at least one ceramide-type compound, and a cosmetic method using the composition. [Background technology]

[0002] Ceramides present in the stratum corneum of the skin form a lipid barrier necessary for retaining moisture and play a crucial role in maintaining moisture within the skin. Ceramides in the stratum corneum are produced by the breakdown of cerebrosides by an enzyme known as cerebrosidase. Ceramides are partially converted into phytosphingosine and sphingosine by the enzyme known as ceramidase. Phytosphingosine and sphingosine play important roles in regulating cell proliferation and differentiation. Six different ceramide types, each with a different function, exist in human skin.

[0003] There are several commercially available cosmetics that contain ceramides with a considerable amount of one or more types of oils.

[0004] In addition, the formulation of environmentally friendly cosmetics, designed and developed with environmental issues in mind, is becoming a major goal in addressing global challenges.

[0005] Therefore, it is essential to propose more sustainable compositions, preparation methods, and ingredients to address these environmental problems.

[0006] In this context, it is important to develop novel cosmetic compositions with a better carbon footprint, particularly by promoting the use of renewable raw materials and / or materials with a good index of naturalness and / or materials of natural origin. [Prior art documents] [Patent Documents]

[0007] [Patent Document 1] Patent Application DE 4424530 [Patent Document 2] Patent Application DE 4424533 [Patent Document 3] Patent Application DE 4402929 [Patent Document 4] Patent Application DE 4420736 [Patent Document 5] WO 95 / 23807 [Patent Document 6] WO 94 / 07844 [Patent Document 7] EP-A-0 646 572 [Patent Document 8] WO 95 / 16665 [Patent Document 9] FR-2 673 179 [Patent Document 10] EP-A-0 227 994 [Patent Document 11] WO 94 / 24097 [Patent Document 12] WO 94 / 10131 [Patent Document 13] EP-A-0500437 [Patent Document 14] EP-A-0647617 [Patent Document 15] Patent application FR 2889448 [Patent Document 16] Patent application FR 2851465 [Patent Document 17] Patent application FR 2853533 [Patent Document 18] WO03 / 068824 [Non-patent literature]

[0008] [Non-Patent Document 1] “The skin barrier: An extraordinary interface with an exceptional lipid organization”, Progress in Lipid Research 92 (2023) 101252, J Bouwstra et al., Figure 2, p. 4 [Non-Patent Document 2] AP Tulloch, JFT Spencer and PAJ Gorin, Can. J. Chem. (1962), 40, 1326. [Non-Patent Document 3] U. Gobbert, S. Lang and F. Wagner, Biotechnology Letters (1984), 6 (4), 225. [Non-Patent Document 4] D. Haferburg, R. Hommel, R. Claus, and HP Kleber, Adv. Biochem. Ing. / Biotechnol. (1986), pp. 33, 53-90. [Non-Patent Document 5] Fermentation (edited by RM Lafferty) by F. Wagner, H. Bock, and A. Kretschmar (1981), pp. 181-192, Springer Verlag, Vienna. [Non-Patent Document 6] Walter Noll's Chemistry and Technology of Silicones (1968), Academic Press [Non-Patent Document 7] Cosmetics and Toiletries, Vol. 91, January 1976, pp. 27-32, Todd & Byers, Volatile Silicone Fluids for Cosmetics [Non-Patent Document 8] D. Campoccia et al., "Semisynthetic resorbable materials from hyaluronan esterification", Biomaterials 19 (1998) pp. 2101-2127 [Overview of the project] [Problems that the invention aims to solve]

[0009] In cosmetics containing ceramide-type compounds and a considerable amount of oil, the ceramide-type compounds are dissolved in the oil and do not tend to form useful microsheet structures when applied to keratinous substances such as skin. Therefore, there is a need to provide compositions that can produce microsheet structures containing ceramide-type compounds.

[0010] On the other hand, because ceramide-type compounds have low solubility in water, dispersions of ceramide-type compounds have been found to be unstable in some cases. Therefore, there is another need to provide stable compositions containing ceramide-type compounds.

[0011] The object of the present invention is to provide a stable composition that can form a microsheet structure containing a ceramide-type compound. [Means for solving the problem]

[0012] The above objective of the present invention is, (a) at least one ceramide-type compound, and (b) at least one glycolipid A composition comprising, preferably a cosmetic composition, more preferably a skin cosmetic composition, This can be achieved by a composition in which the amount of (c) oil in the composition is less than 5% by mass, preferably less than 3% by mass, and more preferably less than 1% by mass, relative to the total mass of the composition.

[0013] (a) Ceramide-type compounds are given by the following formula (I):

[0014] [ka]

[0015] [In the formula, - R1 is a linear or branched saturated or unsaturated hydrocarbon group C1~C 50 Preferably C5~C 50 This represents a group which may be substituted with one or more hydroxyl groups and / or optionally interrupted with one or more oxycarbonyl (-O-CO-) groups or carbonyloxy (-CO-O-) groups. - R2 is a linear or branched saturated or unsaturated hydrocarbon group C1~C 50 Preferably C5~C 50 This represents a group which may be substituted with one or more hydroxyl groups and / or optionally interrupted with one or more oxycarbonyl (-O-CO-) or carbonyloxy (-CO-O-) groups. It can be represented by [this].

[0016] The amount of (a) ceramide-type compound in the composition according to the present invention may be 0.001% to 10% by mass, preferably 0.005% to 5% by mass, and more preferably 0.01% to 1% by mass, based on the total mass of the composition.

[0017] (b) The glycolipid may be selected from the group consisting of rhamnolipids, sophorolipids, and mixtures thereof, preferably from rhamnolipids.

[0018] The amount of (b) glycolipid in the composition according to the present invention may be 0.01% to 20% by mass, preferably 0.1% to 15% by mass, and more preferably 1% to 10% by mass, based on the total mass of the composition.

[0019] The composition according to the present invention may further contain (d) at least one first compound selected from the group consisting of (d1) fatty acids, (d2) aliphatic alcohols, and mixtures thereof.

[0020] (d1) Fatty acids are C4~C 24 Preferably C6~C 22 , more preferably C8~C 20They can be selected from saturated or unsaturated linear or branched fatty acids.

[0021] (b2) The aliphatic alcohol can be selected from the group consisting of cetyl alcohol, cetearyl alcohol, stearyl alcohol, behenyl alcohol, oleyl alcohol, and mixtures thereof.

[0022] The amount of (d) the first compound in the composition according to the present invention may be 0.01% to 15% by mass, preferably 0.05% to 10% by mass, and more preferably 0.1% to 5% by mass, based on the total mass of the composition.

[0023] The composition according to the present invention may further contain (e) at least one second compound selected from the group consisting of (e1) polylysine, (e2) polysaccharides, (e3) polyamino acids and their salts, (e4) proteins, and mixtures thereof.

[0024] (e2) The polysaccharide may be selected from the group consisting of chitosan, hyaluronic acid and its derivatives, polysaccharides derived from microorganisms, and mixtures thereof, preferably from the group consisting of chitosan, hyaluronic acid and its salts, xanthan gum, and mixtures thereof, and more preferably from the group consisting of chitosan, sodium hyaluronate, xanthan gum, and mixtures thereof.

[0025] (e3) Polyamino acids can be selected from polyglutamic acids.

[0026] (e4) The protein may be of plant origin.

[0027] The amount of (e) the second compound in the composition according to the present invention may be 0.001% to 15% by mass, preferably 0.005% to 10% by mass, and more preferably 0.1% to 5% by mass, based on the total mass of the composition.

[0028] The present invention also relates to a cosmetic method for keratinous substances such as skin, Steps of applying the composition according to the present invention to a keratin substance. This also includes information about beauty methods. [Brief explanation of the drawing]

[0029] [Figure 1] This is a micrograph obtained by microscopic observation of the composition according to Example 1. [Figure 2] This is a micrograph obtained by microscopic observation of the composition according to Example 2. [Figure 3] This is a micrograph obtained by microscopic observation of the composition according to Example 4. [Figure 4] This is a micrograph obtained by microscopic observation of the composition according to Example 5. [Modes for carrying out the invention]

[0030] As a result of diligent research, the inventors have discovered that it is possible to provide a stable composition that can form a microsheet structure containing a ceramide-type compound.

[0031] Therefore, the composition according to the present invention is (a) at least one ceramide-type compound, and (b) at least one glycolipid Includes, The amount of (c) oil in the composition is less than 5% by mass, preferably less than 3% by mass, and more preferably less than 1% by mass, relative to the total mass of the composition.

[0032] The composition according to the present invention can form or includes at least one microsheet structure in the form of a small sheet with a size in the micron range.

[0033] The microsheet structure can be identified by microscopic observation. The microsheet structure may have a length or width of 1000 μm or less, preferably 750 μm or less, and more preferably 500 μm or less.

[0034] The thickness of the microsheet structure is not limited. The thickness of the microsheet structure may be very small, such as 10 μm or less, preferably 5 μm or less, and more preferably 1 μm or less.

[0035] The microsheet structure contains (a) a ceramide-type compound. The microsheet structure can be prepared from a complex formed by (a) a ceramide-type compound and (b) a glycolipid.

[0036] (a) Ceramide-type compounds are difficult to dissolve or disperse in water, for example. Therefore, (a) ceramide-type compounds tend to crystallize and form aggregates or precipitates.

[0037] However, the above-mentioned complex containing at least a microsheet-type (a) ceramide compound can be stably dispersed in water, for example. Therefore, the composition according to the present invention is so stable that it does not form any aggregates or precipitates based on the (a) ceramide compound, or forms only very small amounts of aggregates or precipitates based on the (a) ceramide compound.

[0038] (a) Ceramide-type compounds are known to function as humectants that can provide a moist or wet feeling, and / or as whitening agents that can whiten or lighten keratinous substances such as skin. In addition, (a) ceramide-type compounds are also known to improve the barrier effect of keratinous substances such as skin.

[0039] Therefore, the composition according to the present invention can provide various cosmetic effects derived from (a) ceramide-type compounds, such as a skin moisturizing effect, a skin whitening effect, and an effect of protecting the skin by strengthening the skin's barrier function when the stratum corneum is damaged, for example by dry skin.

[0040] Furthermore, the microsheet structure containing (a) a ceramide-type compound allows the composition according to the present invention to effectively adhere the (a) ceramide-type compound to keratinous substances such as skin. The microsheet structure can easily adhere to the skin and therefore can easily exert the effects derived from the (a) ceramide-type compound.

[0041] Therefore, it is possible to enhance the inherent properties of ceramide-type compounds, such as (a) moisturizing effect on the skin and strengthening of the skin's barrier function.

[0042] Furthermore, (a) the microsheet structure containing the ceramide-type compound can impart a smooth texture and improve the appearance of the skin by reducing the visibility of fine lines and wrinkles.

[0043] In addition, the microsheet structure in the composition according to the present invention can impart to the composition a unique optical effect, such as a pearly luster due to light interference.

[0044] On the other hand, (b) glycolipids are known to possess unique biological activities, such as anti-inflammatory, anti-allergic, and antibacterial effects. Therefore, microsheet structures containing (b) glycolipids are thought to be useful for the care of keratinous substances such as skin. In particular, the compositions according to the present invention are thought to be useful for the treatment or care of acne-prone skin.

[0045] (a) Ceramide-type compounds and / or (b) glycolipids may be of natural origin, renewable materials, and biodegradable. Therefore, compositions according to the present invention may contain environmentally friendly components.

[0046] The present invention will be described in more detail below.

[0047] [Composition] The composition according to the present invention is (a) at least one ceramide-type compound, and (b) at least one glycolipid Includes, The amount of (c) oil in the composition is less than 5% by mass, preferably less than 3% by mass, and more preferably less than 1% by mass, relative to the total mass of the composition.

[0048] (Ceramide-type compounds) The composition according to the present invention comprises (a) at least one ceramide-type compound. A single type of ceramide-type compound or a combination of different types of (a) ceramide-type compounds can be used.

[0049] (a) Ceramide-type compounds can form complexes with at least (b) glycolipids.

[0050] According to the present invention, the term "ceramide-type compound" is understood to mean natural or synthetic ceramides and / or glycoceramides and / or pseudoceramides and / or neoceramides.

[0051] Ceramide compounds are disclosed, for example, in patent applications DE 4424530, DE 4424533, DE 4402929, DE 4420736, WO 95 / 23807, WO 94 / 07844, EP-A-0 646 572, WO 95 / 16665, FR-2 673 179, EP-A-0 227 994, WO 94 / 07844, WO 94 / 24097 and WO 94 / 10131, as well as in the publication "The skin barrier: An extraordinary interface with an exceptional lipid organization," Progress in Lipid Research 92 (2023) 101252, J Bouwstra et al., in Figures 2 and 4, and these teachings are incorporated herein by reference.

[0052] (a) Ceramide-type compounds are given by the following formula (I):

[0053] [ka]

[0054] [In the formula, - R1 represents a linear or branched saturated or unsaturated hydrocarbon group C1 to C 50 , preferably C5 to C 50 , which group may be substituted with one or more hydroxyl groups, and / or may optionally be interrupted by one or more oxycarbonyl (-O-CO-) groups or carbonyloxy (-CO-O-) groups, - R2 represents a linear or branched saturated or unsaturated hydrocarbon group C1 to C 50 , preferably C5 to C 50 , which group may be substituted with one or more hydroxyl groups, and / or may optionally be interrupted by one or more oxycarbonyl (-O-CO-) groups or carbonyloxy (-CO-O-) groups] can be represented by.

[0055] In a preferred embodiment, the (a) ceramide-type compound is a compound of formula (I) [wherein R1 represents a linear or branched saturated or unsaturated hydrocarbon group C 14 to C 22 , preferably C 14 to C 20 , for example C 15 or C 16 or C 17 , which group may be substituted with one or more hydroxyl groups, and / or may optionally be interrupted by one or more oxycarbonyl (-O-CO-) groups or carbonyloxy (-CO-O-) groups; R2 represents a linear or branched saturated or unsaturated hydrocarbon group C 14 to C 22 , preferably C 14 to C 20 , for example C 15 , which group may be substituted with one or more hydroxyl groups, and / or may optionally be interrupted by an oxycarbonyl (-O-CO-) group or a carbonyloxy (-CO-O-) group]

[0056] In preferred embodiments, (a) the ceramide-type compound is a compound of formula (I) [wherein R1 is a linear or branched saturated or unsaturated hydrocarbon group C]. 15 or C 16 or C 17 This represents a group which may be substituted with one or more hydroxyl groups and / or optionally interrupted with one or more oxycarbonyl (-O-CO-) or carbonyloxy (-CO-O-) groups, and R2 is a linear or branched saturated or unsaturated hydrocarbon group C 15 This represents a group which may be substituted with one or more hydroxyl groups and / or may be optionally interrupted by an oxycarbonyl (-O-CO-) group or a carbonyloxy (-CO-O-) group.

[0057] Such compounds include, for example, - 2-N-Linoleoylamino-octadecane-1,3-diol, - N-oleoyldihydrosphingosine (INCI), - 2-N-palmitoylamino-octadecane-1,3-diol, - 2-N-stearoylamino-octadecane-1,3-diol, - 2-N-[2-hydroxy-palmitoyl]-amino-octadecane-1,3-diol, - 2-N-stearoylamino-octadecane-1,3,4triol, especially N-stearoylphytosphingosine, - 2-N-palmitoylamino-hexadecane-1,3-diol, Or a mixture of these compounds.

[0058] According to a preferred embodiment, the composition according to the present invention preferably comprises (a) at least one ceramide-type compound selected from ceramides NdS, AdS, OdS, EOdS, NS, AS, OS, EOS, NG, AG, NP, AP, OP, EOP, NH, AH, OH, EOH, NSD, ASD, OSD, EOSD, NT, BS, EO-18:2, EO-18:1, hydroxypalmitoyl sphinganine, 2-oleamide-1,3-octadecanediol, and mixtures thereof.

[0059] According to a preferred embodiment, the composition according to the present invention comprises (a) at least one ceramide-type compound selected from ceramides NS, AS, OS, EOS, NP, AP, OP, EOP, hydroxypalmitoyl sphinganine, 2-oleamide-1,3-octadecanediol, and mixtures thereof.

[0060] According to a preferred embodiment, the composition according to the present invention comprises (a) at least one ceramide-type compound selected from ceramide NS, AS, EOS, NP, AP, EOP, hydroxypalmitoyl sphinganine, 2-oleamide-1,3-octadecanediol, and mixtures thereof, and more preferably selected from ceramide NS, AS, EOS, NP, AP, EOP, and mixtures thereof.

[0061] According to a preferred embodiment, the composition according to the present invention preferably comprises at least two ceramide-type compounds selected from ceramides NS, AS, EOS, NP, AP, and EOP.

[0062] According to a preferred embodiment, the composition according to the present invention preferably comprises two ceramide-type compounds selected from a mixture of ceramides (NS and AS) or (NS and EOS), or (NS and NP), or (NS and AP), or (NS and EOP), or (AS and EOS), or (AS and NP), or (AS and EOP), or (EOS and NP), or (EOS and AP), or (EOS and EOP), or (NP and AP), or (NP and EOP), or (AP and EOP).

[0063] According to a preferred embodiment, the composition according to the present invention comprises at least three ceramide-type compounds selected from ceramides NS, AS, EOS, NP, AP, and EOP.

[0064] According to a preferred embodiment, the composition according to the present invention preferably comprises three ceramide-type compounds selected from ceramides (NS, AS, and EOS), or (NS, AS, and NP), or (NS, AS, and AP), or (NS, AS, and EOP), or (AS, EOS, and NP), or (AS, EOS, and AP), or (AS, EOS, and EOP), or (EOS, NP, and AP), or (NP, AP, and EOP).

[0065] According to a preferred embodiment, the composition according to the present invention comprises at least four ceramide-type compounds selected from ceramides NS, AS, EOS, NP, AP, and EOP.

[0066] In a preferred embodiment, the composition according to the present invention preferably comprises four ceramide-type compounds selected from ceramides (NS and AS and EOS and NP), or (NS and AS and EOS and AP), or (NS and AS, and EOS and EOP), or (NS and EOS and NP and AP), or (NS and EOS and NP and EOP), or a mixture of (NS and NP and AP and EOP).

[0067] According to a preferred embodiment, the composition according to the present invention comprises at least five ceramide-type compounds selected from ceramides NS, AS, EOS, NP, AP, and EOP.

[0068] According to a preferred embodiment, the composition according to the present invention preferably comprises five ceramide-type compounds selected from ceramides (NS and AS and EOS and NP and AP) or (NS and AS and EOS and NP and EOP) or a mixture of (AS and EOS and NP and AP and EOP).

[0069] According to a preferred embodiment, the composition according to the present invention preferably comprises one, two, three, or four ceramide-type compounds selected from ceramides NS, AS, EOS, NP, AP, and EOP.

[0070] The synthesis of ceramides is described, for example, in EP-A-0500437 and EP-A-0647617.

[0071] Hydroxypalmitoyl sphinganine is a well-known and commercially available product.

[0072] 2-Oleamido-1,3-Octadecanediol is a known product and is commercially available.

[0073] Ceramide NP, also known as N-stearoyl-phytosphingosine, is a well-known and commercially available product.

[0074] Ceramide AP, also known as N-(2-hydroxystearoyl)phytosphingosine, is a well-known and commercially available product.

[0075] Ceramide EOP, also known as stearoyloxyheptacosanoyl-C27-phytosphingosine or 30-[[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]amino]-30-oxotriacontyl(9Z,12Z)-9,12-octadecadienoate, is a well-known and commercially available product.

[0076] Ceramide NdS, also known as N-tetracosanoyl sphinganine, is a well-known and commercially available product.

[0077] Ceramide AdS, also known as 2-hydroxy-N-[(1S,2R)-2-hydroxy(hydroxymethyl)heptadecyl]tetracosaneamide, is a well-known and commercially available product.

[0078] Ceramide EOdS is a well-known product also known as 9,12-octadecadienoic acid (9Z,12Z)-,30-[[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]amino]-30-oxotriacontyl ester.

[0079] Ceramide NS is also known as N-stearoyl sphinganin.

[0080] Ceramide AS, also known as 2-hydroxy-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecene-1-yl]tetracosaneamide, is a well-known product that is commercially available.

[0081] Ceramide EOS is a well-known product also known as 9,12-octadecadienoic acid (9Z,12Z)-,30-[[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecene-1-yl]amino]-30-oxotriacontyl ester.

[0082] Ceramide NG, also known as N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecene-1-yl]octadecanamide or N-octadecanoylsphingosine, is a well-known and commercially available product.

[0083] Ceramide NH is a well-known product also known as N-[(1S,2R,3E)-2,5-dihydroxy-1-(hydroxymethyl)-3-heptadecene-1-yl]tetracosaneamide.

[0084] Ceramide AH is a well-known product also known as N-[(1S,2R,3E)-2,5-dihydroxy-1-(hydroxymethyl)-3-heptadecene-1-yl]-2-hydroxytetracosamide.

[0085] Ceramide EOH is a well-known product also known as 30-[[(1S,2R,3E)-2,5-dihydroxy-1-(hydroxymethyl)-3-heptadecene-1-yl]amino]-30-oxotriacontyl(9Z,12Z)-9,12-octadecadienoate.

[0086] (a) The ceramide-type compound may preferably be selected from the group consisting of ceramide AP, ceramide NP, ceramide EOP, and mixtures thereof.

[0087] (a) The ceramide-type compound may more preferably be ceramide NP, ceramide AP, or mixtures thereof.

[0088] The amount of (a) ceramide-type compound in the composition according to the present invention may be 0.001% by mass or more, preferably 0.005% by mass or more, and more preferably 0.01% by mass or more, based on the total mass of the composition.

[0089] On the other hand, the amount of (a) ceramide-type compound in the composition according to the present invention may be 10% by mass or less, preferably 5% by mass or less, and more preferably 1% by mass or less, based on the total mass of the composition.

[0090] Therefore, the amount of (a) ceramide-type compound in the composition according to the present invention may be 0.001% to 10% by mass, preferably 0.005% to 5% by mass, and more preferably 0.01% to 1% by mass, based on the total mass of the composition.

[0091] In one embodiment of the present invention, the composition is - A first ceramide selected from ceramide AP, NP, EOP, AS, NS, and EOS in an amount of at least 0.0001% to 5% by mass, preferably 0.001% to 1% by mass, and more preferably 0.005% to 0.1% by mass, relative to the total mass of the composition. - A second ceramide selected from ceramide AP, NP, EOP, AS, NS, and EOS in an amount of at least 0.0001% to 5% by mass, preferably 0.001% to 1% by mass, and more preferably 0.005% to 0.1% by mass, relative to the total mass of the composition. - The composition comprises at least 0.000001% to 1% by mass, preferably 0.000005% to 0.01% by mass, and more preferably 0.000007% to 0.001% by mass of a third ceramide selected from AP, NP, EOP, AS, NS, and EOS, based on the total mass of the composition. The first, second, and third ceramides are different from each other.

[0092] (b) Glycolipids The composition according to the present invention comprises (b) at least one glycolipid. A single type of glycolipid or a combination of different types of glycolipids can be used.

[0093] The term "glycolipid" is understood to mean a compound formed from lipids to which one or more sugar compounds are bonded.

[0094] According to the present invention, (b) the glycolipid is selected from sophorolipid, rhamnolipid, and mixtures thereof, more preferably from rhamnolipid.

[0095] Sophorolipid: (b) The glycolipid contains a sophorose moiety and has the following general formula (II):

[0096] [ka]

[0097] (In the formula, - R 3 and R 4 Each represents a hydrogen atom or an acetyl group. - R 5This represents a saturated or unsaturated hydroxylated or unhydroxylated hydrocarbon group having 1 to 9 carbon atoms, preferably methyl. - R 6 This represents a saturated or unsaturated hydroxylated or unhydroxylated hydrocarbon group having 1 to 19 carbon atoms. However, R 5 Base and R 6 The total number of carbon atoms in the group shall not exceed 20, preferably 14 to 18. - R 7 This represents a hydrogen atom, - R 8 This represents the hydroxyl group OH. or R 7 and R 8 (They form a lactone ring together.) A sophorolipid may be selected from those that can be represented by the following:

[0098] Sophorolipid is R 7 represents a hydrogen atom, R 8 The form of an open-chain free acid in which the hydroxyl group OH represents, or formula (III):

[0099] [ka]

[0100] (In the formula, - R 3 , R 4 , R 5 , and R 6 As defined above, However, R 3 and R 4 (At least one of them represents an acetyl group.) As shown by, the lactone ring is R 7 and R 8 Either of the lactone forms formed between them can be incorporated into the composition according to the present invention.

[0101] Sophorolipids can be produced by yeast cells, such as those of Torulopsis apicola and Torulopsis bombicola. Fermentation methods generally use sugars and alkanes as substrates.

[0102] Appropriate fermentation methods are outlined in AP Tulloch, JFT Spencer, and PAJ Gorin, Can. J. Chem. (1962), 40, 1326, and in U. Gobbert, S. Lang, and F. Wagner, Biotechnology Letters (1984), 6 (4), 225. The resulting product is a mixture of various open-chain sophorolipids and sophorolipid lactones, which may be used in mixture form or the required form may be isolated.

[0103] Examples of sophorolipids that can be used include products sold by Givaudan under the name Sopholiances and products sold by BASF under the name BioToLife.

[0104] Rhamnolipid: (b) The glycolipid may be selected from rhamnolipids.

[0105] The composition according to the present invention preferably comprises one or more rhamnolipids.

[0106] Rhamnolipids are glycolipids produced by various bacterial species. Rhamnolipids consist of one rhamnose fragment (monorhamnolipid) or two rhamnose fragments (diramnolipid) linked by glycosidic bonds to one, two, or three chains of β-hydroxylated fatty acids that are linked to each other by ester bonds.

[0107] Preferably, rhamnolipid is given by the following formula (VI):

[0108] [ka]

[0109] (In the formula, - m represents an integer equal to 2, 1, or 0. - n represents an integer equal to 1 or 0. - R1 and R2 each independently represent the same or different hydrocarbon group having 2 to 24 carbon atoms, preferably 5 to 13 carbon atoms, branched or unbranched, substituted or unsubstituted, particularly hydroxysubstituted, saturated or unsaturated, preferably monounsaturated, doublyunsaturated or tripunsaturated alkyl group. The corresponding monoramnolipids and diramnolipids, as well as their salts, solvates, and optical isomers, are selected.

[0110] Therefore, when n is equal to 0, equation (VI) protects monoramnolipid, and when n is equal to 1, it protects diramnolipid.

[0111] The composition according to the present invention preferably comprises at least one diramnolipid.

[0112] The composition according to the present invention is preferably of formula (VI) (wherein, - m represents an integer equal to 2, 1, or 0. - n represents an integer equal to 1, - R1 and R2 each independently represent the same or different hydrocarbon group having 2 to 24 carbon atoms, preferably 5 to 13 carbon atoms, branched or unbranched, substituted or unsubstituted, particularly hydroxysubstituted, saturated or unsaturated, preferably monounsaturated, doublyunsaturated or tripunsaturated alkyl group. The material comprises at least one diram nolipid, and further includes salts thereof, solvates thereof, and optical isomers thereof.

[0113] The glycosidic bond between the two rhamnose fragments may be in an alpha configuration or a beta configuration, and is preferably in an alpha configuration.

[0114] In the context of the present invention, - The salts of diramnolipid of formula (VI) are, more specifically, carboxylate salts thereof with organic or inorganic cations, particularly cations selected from sodium, potassium, calcium, and ammonium. - The solvated form of the diram nolipid of formula (VI) is, more specifically, a solvated form with one or more molecules of water or an organic solvent, such as a hydrate or a solvate of a linear or branched alcohol such as ethanol or isopropanol, and the optically active carbon atom of the fatty acid is preferably in the form of an R enantiomer. - The term "alkyl" group refers to a saturated linear or branched aliphatic group, for example, a C1-C group having a linear or branched hydrocarbon chain of 1-20 carbon atoms. 20 Alkyl groups, more specifically, include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, or eicosyl.

[0115] The composition according to the present invention is preferably of formula (VI) [wherein, - m represents an integer equal to 2, 1, or 0. - n represents an integer equal to 1, - R1 and R2 are either the same or different, and consist of pentenyl, hexenyl, heptenyl, octenyl, nonenyl, decenyl, undecenyl, dodecenyl and tridecenyl groups and formula-(CH2) o The base of CH3 (where o is an integer in the range of 1 to 23, particularly 3 to 15, and more specifically 4 to 12) is selected. It contains at least one type of diramnolipid.

[0116] According to one embodiment of the present invention, the composition comprises at least one diramnolipid of general formula (VI) (wherein m is equal to 1).

[0117] According to one embodiment of the present invention, the composition according to the present invention comprises a mixture of at least two, preferably at least three, diramnolipids of general formula (VI) (wherein m is preferably equal to 1).

[0118] According to another embodiment of the present invention, the composition according to the present invention comprises a mixture containing at least one monorhamnolipid.

[0119] More preferably, the composition according to the present invention is of the following formula (VII):

[0120] [ka]

[0121] [In the formula, - m represents an integer equal to 2, 1, or 0, preferably m is equal to 1. - n represents an integer equal to 1, - R1 is -(CH2) p -CH3 group (wherein p is an integer varying from 1 to 23, preferably from 4 to 12), - R2 is -(CH2) q -CH3 group (wherein q is an integer varying from 1 to 23, preferably from 4 to 12) The material comprises at least one diram nolipid, and further includes salts thereof, solvates thereof, and optical isomers thereof.

[0122] Examples of diramnolipids of formula (VII) that may be suitable for the present invention include, in a non-limiting manner, compounds of formula di-RL-CXCY, such as those specified in Table 1 below.

[0123] The formula di-RL-CXCY is an alternative notation for diramnolipid (di-RL) functionalized with two bases R1 and R2, represented by the symbols CX and CY (where the integers X and Y are equal to p+4 and q+4, respectively).

[0124] [Table 1]

[0125] According to a preferred embodiment, the composition according to the present invention comprises at least one diramnolipid of formula (VII) (wherein p and q are the same and equal to 6, and m is equal to 1), also known as di-RL-C10C10, or one of their salts, solvates, and optical isomers.

[0126] Preferably, the diramnolipid of formula (VII) (wherein p and q are the same and equal to 6, and m is equal to 1) is present in the composition according to the present invention in a proportion of at least 50% by mass, preferably 51% to 85% by mass, based on the total mass of the rhamnolipid.

[0127] According to a preferred embodiment, the composition according to the present invention comprises at least one diramnolipid of formula (VII) (wherein m is equal to 1, p is equal to 6, and q is equal to 8), or a salt, solvate, or optical isomer thereof.

[0128] According to a preferred embodiment, the composition according to the present invention is of formula (VI) [wherein n and m are equal to 1, and R1 is -(CH2)] o The present invention comprises at least one diram nolipid, or a salt, solvate, or optical isomer thereof, wherein R1 represents a CH3 group, o is an integer varying from 4 to 12, and R2 is selected from pentenyl, hexenyl, heptenyl, octenyl, nonenyl, decenyl, undecenyl, dodecenyl, and tridecenyl groups, preferably R1 represents a -(CH2)6CH3 group and R2 represents a nonenyl group.

[0129] According to a preferred embodiment, the composition according to the present invention comprises at least two, and more specifically at least three, of the previously defined formula (VI) or formula (VII), more specifically: - Diramnolipid of formula (VII) (where p and q are the same and equal to 6, and m is equal to 1), - Diramnolipid of formula (VII) (wherein m is equal to 1, p is equal to 6, and q is equal to 8), and - Equation (VI) [wherein n and m are equal to 1, and R1 is -(CH2)] o The mixture comprises a mixture of diram nolipids selected from at least one diram nolipid, where R1 represents a CH3 group, o is an integer varying from 4 to 12, and R2 is selected from pentenyl, hexenyl, heptenyl, octenyl, nonenyl, decenyl, undecenyl, dodecenyl, and tridecenyl groups, preferably R1 represents a -(CH2)6CH3 group and R2 represents a nonenyl group.

[0130] Preferably, the composition according to the present invention, as follows: - Diramnolipid of formula (VII) (wherein p and q are the same and equal to 6, and m is equal to 1) in an amount of at least 50% by mass, preferably 51% to 85% by mass, relative to the total mass of rhamnolipid. - Diramnolipid of formula (VII) (wherein p is equal to 6, q is equal to 8, and m is equal to 1) in an amount of 0.5% to 25% by mass, preferably 5% to 15% by mass, relative to the total mass of rhamnolipid, and - The mixture comprises a mixture of at least two, particularly at least three, diramnolipids of formula (VI) or formula (VII), selected from diramnolipids of formula (VI) [wherein n and m are equal to 1, R1 represents a -(CH2)6CH3 group, and R2 represents a nonenyl group], in an amount of 0.5% to 15% by mass, preferably 3% to 12% by mass, and preferably 5% to 10% by mass, relative to the total mass of the rhamnolipid.

[0131] Rhamnolipid is usually prepared from bacterial strains such as Pseudomonas by methods known to those skilled in the art.

[0132] Appropriate fermentation methods are outlined in Adv. Biochem. Ing. / Biotechnol. (1986), pp. 33, 53-90, by D. Haferburg, R. Hommel, R. Claus, and H.P. Kleber, and in Fermentation (edited by RM Lafferty), pp. 181-192, by F. Wagner, H. Bock, and A. Kretschmar, Springer Verlag, Vienna.

[0133] As rhamnolipid, you may use the product sold by Evonik under the name Rheance One (INCI name: glycolipid).

[0134] The amount of (b) glycolipid in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more, based on the total mass of the composition.

[0135] On the other hand, the amount of (b) glycolipid in the composition according to the present invention may be 20% by mass or less, preferably 15% by mass or less, and more preferably 10% by mass or less, based on the total mass of the composition.

[0136] Therefore, the amount of (b) glycolipid in the composition according to the present invention may be 0.01% to 20% by mass, preferably 0.1% to 15% by mass, and more preferably 1% to 10% by mass, based on the total mass of the composition.

[0137] (oil) The composition according to the present invention may (c) contain at least one type of oil. Two or more types of oil may be present in combination. Therefore, a single type of oil or a combination of different types of oil may be present.

[0138] (c) The oil is different from (d) the first compound or (e) the second compound, which will be described later.

[0139] Here, "oil" refers to fatty compounds or fatty substances that are in liquid or paste (non-solid) form at atmospheric pressure (760 mmHg) and room temperature (25°C). Oils commonly used in cosmetics can be used individually or in combination. These oils may be volatile or non-volatile.

[0140] (c) The oil may be a non-polar oil such as hydrocarbon oil or silicone oil, a vegetable oil or animal oil and a polar oil such as ester oil or ether oil, or a mixture thereof.

[0141] (c) The oil may be selected from the group consisting of plant or animal-derived oils, synthetic oils, silicone oils, hydrocarbon oils, and mixtures thereof.

[0142] Examples of vegetable oils include, for instance, apricot oil, linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, soybean oil, peanut oil, and mixtures thereof.

[0143] Examples of animal oils include squalene and squalane.

[0144] Examples of synthetic oils include alkane oils, such as isododecane and isohexadecane, ester oils, ether oils, and artificial triglycerides.

[0145] Ester oils are preferably saturated or unsaturated, linear or branched C1-C123. 26 Aliphatic monoacid or polyacid and saturated or unsaturated linear or branched C1-C12 chains. 26 A liquid ester of an aliphatic monoalcohol or polyalcohol, wherein the total number of carbon atoms in these esters is 10 or more.

[0146] Preferably, in the case of a monoalcohol ester, at least one of the alcohols and acids from which the ester of the present invention is derived is branched.

[0147] Among monoesters of monoacids and monoalcohols, examples include ethyl palmitate, ethylhexyl palmitate, isopropyl palmitate, dicaprylyl carbonate, alkyl myristate, for example isopropyl myristate or ethyl myristate, isocetyl stearate, 2-ethylhexyl isononanoate, isononyl isononanoate, isodecyl neopentanoate, and isostearyl neopentanoate.

[0148] C4~C 22 Dicarboxylic acid or tricarboxylic acid and C1-C 22 Esters with alcohols, and non-sugars C4-C with monocarboxylic acids, dicarboxylic acids, or tricarboxylic acids. 26 Esters with dihydroxy, trihydroxy, tetrahydroxy, or pentahydroxy alcohols can also be used.

[0149] In particular, diethyl sebacate, isopropyl lauroyl sarcosinate, diisopropyl sebacate, bis(2-ethylhexyl) sebacate, diisopropyl adipate, di-n-propyl adipate, dioctyl adipate, bis(2-ethylhexyl) adipate, diisostearyl adipate, bis(2-ethylhexyl) maleate, triisopropyl citrate, triisocetyl citrate, triisostearyl citrate, glyceryl trilactic acid, glyceryl trioctanoate, trioctyldodecyl citrate, trioleyl citrate, neopentyl glycol diheptanoate, and diethylene glycol diisononanoate.

[0150] As for ester oils, C6~C 30 Preferably C 12 ~C 22Fatty acid sugar esters and diesters can be used. The term "sugar" is meant to refer to oxygen-sparing hydrocarbon compounds that have or do not have aldehyde or ketone functional groups, contain several alcohol functional groups, and contain at least four carbon atoms. These sugars may be monosaccharides, oligosaccharides, or polysaccharides.

[0151] Examples of suitable sugars that can be listed include sucrose (or saccharose), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose, and lactose, as well as their derivatives, particularly alkyl derivatives, such as methyl derivatives, for example, methyl glucose.

[0152] Fatty acid sugar esters are, in particular, the sugars mentioned above, and linear or branched, saturated or unsaturated C6-C6 sugars. 30 Preferably C 12 ~C 22 The group can be selected from those comprising esters or mixtures of esters with fatty acids. If they are unsaturated, these compounds may have 1 to 3 conjugated or unconjugated carbon-carbon double bonds.

[0153] Esters in this modified form can also be selected from monoesters, diesters, triesters, tetraesters, and polyesters, as well as mixtures thereof.

[0154] These esters may be, for example, oleic acid esters, lauric acid esters, palmitic acid esters, myristic acid esters, behenic acid esters, coconut fatty acid esters, stearic acid esters, linoleic acid esters, linolenic acid esters, capric acid esters and arachidonic acid esters, or mixtures thereof, for example, particularly mixed esters of oleopalmitic acid, oleostearic acid and palmitostearic acid, and pentaerythrityl tetraethylhexanoate.

[0155] More specifically, the esters used are monoesters and diesters, particularly monooleates or dioleates of sucrose, glucose or methyl glucose, stearates, behenates, oleopalmitates, linoleates, linolenicates and oleostearates.

[0156] One example that can be cited is the product sold by Amerchol under the name Glucate(registered trademark)DO, which is methyl glucose dioleate.

[0157] Examples of preferred ester oils include, for example, diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanoate, octyldodecyl octanoate, isodecyl neopentanoate, myristyl propionate, 2-ethylhexyl 2-ethylhexanoate, 2-ethylhexyl octanoate, 2-ethylhexyl caprylate / 2-ethylhexyl caprate, methyl palmitate, ethyl palmitate, isopropyl palmitate, and dicaprylate. Examples include lyl, isopropyl lauroyl sarcosinate, isononyl isononanoate, ethylhexyl palmitate, isohexyl laurate, hexyl laurate, isocetyl stearate, isopropyl isostearate, isopropyl myristate, isodecyl oleate, glyceryl tri(2-ethylhexanoate), pentaerythrityl tetra(2-ethylhexanoate), ethylhexyl succinate, diethyl sebacate, cetearyl isononanoate, and mixtures thereof.

[0158] Examples of artificial triglycerides include, for example, caprylcaprylyl glyceride, glyceryl trimyristicate, glyceryl tripalmitate, glyceryl trilinolenate, glyceryl trilaurate, glyceryl tricaprate, glyceryl tricaprylate, tri(caprate / caprylic acid)glyceryl, and tri(caprate / caprylic acid / linolenic acid)glyceryl.

[0159] Examples of silicone oils include, for example, linear organopolysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane; cyclic organopolysiloxanes such as cyclohexasiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane; and mixtures thereof.

[0160] Preferably, the silicone oil is selected from liquid polydialkylsiloxanes, particularly liquid polydimethylsiloxane (PDMS), and liquid polyorganosiloxanes containing at least one aryl group.

[0161] These silicone oils may also be organically modified. Organically modified silicones that can be used in the present invention are silicone oils that are defined above and contain one or more organic functional groups linked in their structure via hydrocarbon groups.

[0162] Organopolysiloxanes are defined in more detail in Walter Noll's *Chemistry and Technology of Silicones* (1968), Academic Press. They may be volatile or non-volatile.

[0163] If these are volatile, the silicone is selected more specifically from those with a boiling point between 60°C and 260°C, and even more specifically from the following: (i) Cyclic polydialkylsiloxanes containing 3 to 7, preferably 4 to 5, silicon atoms. These include, for example, octamethylcyclotetrasiloxane sold by Union Carbide under the name Volatile Silicone® 7207, or by Rhodia under the name Silbione® 70045 V2, decamethylcyclopentasiloxane sold by Union Carbide under the name Volatile Silicone® 7158, by Rhodia under the name Silbione® 70045 V5, and dodecamethylcyclopentasiloxane sold by Momentive Performance Materials under the name Silsoft 1217, as well as mixtures thereof. Cyclocopolymers of the type dimethylsiloxane / methylalkylsiloxane, for example, Silicone Volatile® FZ 3109 sold by Union Carbide, which has the following formula.

[0164] [ka]

[0165] Other examples include mixtures of cyclic polydialkylsiloxanes and organosilicon compounds, such as a mixture of octamethylcyclotetrasiloxane and tetratrimethylsilylpentaerythritol (50 / 50), and a mixture of octamethylcyclotetrasiloxane and oxy-1,1'-bis(2,2,2',2',3,3'-hexatrimethylsilyloxy)neopentane; and (ii) Contains 2 to 9 silicon atoms and is 5 × 10 at 25°C -6 m 2Linear volatile polydialkylsiloxanes with a viscosity of less than 1 / s. An example is decamethyltetrasiloxane, sold by Toray Silicone under the name SH 200. Silicones belonging to this category are also described in the paper published in Cosmetics and Toiletries, Vol. 91, January 1976, pp. 27-32, by Todd & Byers, in Volatile Silicone Fluids for Cosmetics. The viscosity of silicones is measured at 25°C according to ASTM Standard 445 Appendix C.

[0166] Non-volatile polydialkylsiloxanes can also be used. These non-volatile silicones are selected more specifically from polydialkylsiloxanes, among which polydimethylsiloxanes containing trimethylsilyl terminal groups are the most notable.

[0167] Among these polydialkylsiloxanes, the following commercially available products can be listed without limitation: - Silbione® oils 47 and 70 047 series or Mirasil® oils sold by Rhodia, for example, 70 047 V 500 000 oil. - Mirasil® series oils sold by Rhodia, - Dow Corning's 200 series oil, for example, with a viscosity of 60,000 mmHg 2 DC200 is / s, and - Viscasil® oil manufactured by General Electric, and certain oils in the SF series manufactured by General Electric (SF 96, SF 18).

[0168] Polydimethylsiloxanes containing dimethylsilanol terminal groups, known by the name dimethiconol (CTFA), such as the 48 series oils from Rhodia, can also be mentioned.

[0169] Among silicones containing aryl groups, polydiarylsiloxanes, particularly polydiphenylsiloxanes and polyalkylarylsiloxanes, such as phenyl silicone oil, can be cited.

[0170] Phenylsilicone oil has the following formula:

[0171] [ka]

[0172] (In the formula, R1~R 10 These are, independently of each other, saturated or unsaturated, linear, cyclic or branched C1-C12 30 Hydrocarbon groups, preferably C1-C 12 A hydrocarbon group, more preferably a C1-C6 hydrocarbon group, particularly a methyl, ethyl, propyl, or butyl group. m, n, p, and q are independent integers between 0 and 900, preferably between 0 and 500, and more preferably between 0 and 100, including both ends. However, it may be selected from phenyl silicones (where the sum n+m+q is not 0).

[0173] Examples that can be given include products sold under the following names: - Silbione® oil 70 641 series manufactured by Rhodia, - Rhodorsil® 70 633 series and 763 series oils manufactured by Rhodia. - Dow Corning 556 Cosmetic Grade Fluid oil manufactured by Dow Corning, - Bayer's PK series silicones, for example, product PK20, - Certain oils from General Electric's SF series, such as SF 1023, SF 1154, SF 1250, and SF 1265.

[0174] As phenyl silicone oil, phenyl trimethicone (in the above formula, R1 to R 10 (where is methyl, and p, q, and n = 0, and m = 1) is preferred.

[0175] Organically modified liquid silicones may, in particular, contain polyethylene oxy groups and / or polypropylene oxy groups. Examples include silicone KF-6017 proposed by Shin-Etsu Chemical Co., Ltd., and Silwet® L722 and L77 oils manufactured by Union Carbide.

[0176] Hydrocarbon oils can be selected from the following: - Linear or branched, optionally cyclic C6-C 16 Lower alkanes. Examples that can be given include hexane, undecane, dodecane, tridecane, and isoparaffins, including isohexadecane, isododecane and isodecane as examples; and - Linear or branched hydrocarbons containing more than 16 carbon atoms, such as liquid paraffin, liquid petroleum jelly, polydecene and hydrogenated polyisobutene, such as Parleam®, and squalane.

[0177] Preferred examples of hydrocarbon oils include, for example, linear or branched hydrocarbons such as isohexadecane, isododecane, squalane, mineral oil (e.g., liquid paraffin), paraffin, petrolatum or petrolatum, naphthalene, etc.; hydrogenated polyisobutene, isoeicosane, and decene / butene copolymers; and mixtures thereof.

[0178] The amount of (c) oil (if present) in the composition according to the present invention is less than 5% by mass, preferably less than 3% by mass, and more preferably less than 1% by mass, based on the total mass of the composition.

[0179] In one embodiment, the amount of (c) oil (if present) in the composition according to the present invention may be less than 0.5% by mass, preferably less than 0.3% by mass, and more preferably less than 0.1% by mass, based on the total mass of the composition.

[0180] In another embodiment, the composition according to the present invention may not contain oil.

[0181] (First compound) The composition according to the present invention may contain (d) at least one first compound selected from the group consisting of (d1) fatty acids, (d2) aliphatic alcohols, and mixtures thereof.

[0182] (d) The first compound is different from the second compound (e), which will be described later.

[0183] (d1) fatty acids and (d2) aliphatic alcohols are distinct from each other.

[0184] The amount of (d) the first compound in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more, based on the total mass of the composition.

[0185] On the other hand, the amount of (d) the first compound in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0186] Therefore, the amount of (d) the first compound in the composition according to the present invention may be in the range of 0.01% to 15% by mass, preferably 0.05% to 10% by mass, and more preferably 0.1% to 5% by mass, relative to the total mass of the composition.

[0187] (d1)Fatty acid The composition according to the present invention may contain (d1) at least one fatty acid. A single type of fatty acid or a combination of different types of fatty acids can be used.

[0188] As used herein, the term "fatty acid" means a carboxylic acid having a long-chain aliphatic carbon chain.

[0189] The fatty acid (d1) has at least 4 carbon atoms, preferably at least 6 carbon atoms, more preferably at least 8 carbon atoms. The fatty acid (d1) may comprise up to 24 carbon atoms, preferably up to 22 carbon atoms, more preferably up to 20 carbon atoms. The fatty acid (d1) is C4~C 24 fatty acid, more preferably C6~C 22 fatty acid, even more preferably C8~C 20 fatty acid.

[0190] The fatty acid (d1) may be selected from saturated or unsaturated, linear or branched fatty acids. Therefore, the fatty acid (d1) can be C 10 ~C 20 , preferably C 12 ~C 20 , more preferably C 14 ~C 20 saturated or unsaturated linear or branched fatty acids.

[0191] As the unsaturated linear or branched fatty acid, a monounsaturated linear or branched fatty acid or a polyunsaturated linear or branched fatty acid may be used. Examples of the unsaturated moiety of the unsaturated linear or branched fatty acid include a carbon-carbon double bond or a carbon-carbon triple bond.

[0192] Examples of the saturated fatty acid include caprylic acid (C8), pelargonic acid (C9), capric acid (C 10 ), lauric acid (C 12 ), myristic acid (C 14 ), pentadecanoic acid (C 15 ), palmitic acid (C 16 ), heptadecanoic acid (C 17 ), stearic acid (C 18 ), isostearic acid (C 18 ), nonadecanoic acid (C 19 ), arachidic acid (C 20), behenic acid (C 22 ), and lignoceric acid (C 24 ) can be mentioned.

[0193] Examples of unsaturated fatty acids include myristoleic acid (C 14 ), palmitoleic acid (C 16 ), oleic acid (C 18 ), linoleic acid (C 18 ), linolenic acid (C 18 ), elaidic acid (C 18 ), arachidonic acid (C 20 ), eicosenoic acid (C 20 ), erucic acid (C 22 ), and nervonic acid (C 24 ) can be mentioned.

[0194] The fatty acid (d1) is preferably selected from C 16 to C 18 saturated or unsaturated linear or branched fatty acids, more preferably selected from the group consisting of oleic acid, linoleic acid, linolenic acid, palmitic acid, stearic acid, isostearic acid, and mixtures thereof.

[0195] The fatty acid (d1) may be in the form of its free acid or in the form of its salt. Examples of fatty acid salts include inorganic salts, for example, alkali metal salts (sodium salt, potassium salt, etc.) and alkaline earth metal salts (magnesium salt, calcium salt, etc.), as well as organic salts, for example, ammonium salts (quaternary ammonium salt, etc.) and amine salts (triethanolamine salt, triethylamine salt, etc.). A single type of fatty acid salt, or a combination of different types of fatty acid salts can be used. Furthermore, a combination of one or more fatty acids in free acid form and one or more fatty acids in salt form can be used, and one or more types of salts can also be used.

[0196] The amount of the fatty acid (d1) in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, relative to the total mass of the composition.

[0197] On the other hand, the amount of (d1) fatty acid in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0198] Therefore, the amount of (d1) fatty acid in the composition according to the present invention may be in the range of 0.01% to 15% by mass, preferably 0.05% to 10% by mass, and more preferably 0.1% to 5% by mass, relative to the total mass of the composition.

[0199] (d2) Aliphatic alcohol The composition according to the present invention may contain (d2) at least one aliphatic alcohol. A single type of aliphatic alcohol or a combination of different types of aliphatic alcohols can be used.

[0200] In this specification, the term "aliphatic" refers to the inclusion of a relatively large number of carbon atoms. Therefore, alcohols having four or more, preferably six or more, and more preferably eight or more carbon atoms are included in the range of aliphatic alcohols. Aliphatic alcohols may contain up to 24 carbon atoms, preferably up to 22, and more preferably up to 20 carbon atoms. Aliphatic alcohols may be saturated or unsaturated. Aliphatic alcohols may be linear or branched.

[0201] (d2) The aliphatic alcohol may have the structure R-OH (where R is selected from saturated and unsaturated, linear and branched groups containing 4 to 24 carbon atoms, e.g., 8 to 22 carbon atoms). In at least one embodiment, R is C 12 ~C 24 Alkyl and C 12 ~C 24 The group is selected from alkenyl groups. R may or may not be substituted with at least one hydroxyl group.

[0202] Non-limiting examples of aliphatic alcohols that can be listed (d2) include lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, linoleyl alcohol, undecylenyl alcohol, palmitrail alcohol, arachidonyl alcohol, erucyl alcohol, cetearyl alcohol, and mixtures thereof.

[0203] Suitable examples of (d2) aliphatic alcohols include, but are not limited to, cetyl alcohol, cetearyl alcohol, stearyl alcohol, behenyl alcohol, oleyl alcohol, and mixtures thereof.

[0204] (d2) Aliphatic alcohol may also represent a mixture of aliphatic alcohols, meaning that several species of aliphatic alcohols can coexist in the form of a mixture in commercially available products. According to at least one embodiment, the aliphatic alcohol used in the composition according to the present invention is selected from a mixture of cetyl alcohol and stearyl alcohol (cetearyl alcohol).

[0205] The amount of (d2) aliphatic alcohol in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more, based on the total mass of the composition.

[0206] On the other hand, the amount of (d2) aliphatic alcohol in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0207] Therefore, the amount of (d2) aliphatic alcohol in the composition according to the present invention may be in the range of 0.01% to 15% by mass, preferably 0.05% to 10% by mass, and more preferably 0.1% to 5% by mass, relative to the total mass of the composition.

[0208] (Second compound) The composition according to the present invention may comprise (e) at least one second compound selected from the group consisting of (e1) polylysine, (e2) polysaccharides, (e3) polyamino acids and salts thereof, (e4) proteins, and mixtures thereof.

[0209] The (e) second compound is different from the (d) first compound.

[0210] (e1) polylysine, (e2) polysaccharides, (e3) polyamino acids and salts thereof, and (e4) proteins are different from each other.

[0211] The amount of the (e) second compound in the composition according to the present invention may be 0.001 mass% or more, preferably 0.005 mass% or more, more preferably 0.01 mass% or more, relative to the total mass of the composition.

[0212] On the other hand, the amount of the (e) second compound in the composition according to the present invention may be 15 mass% or less, preferably 10 mass% or less, more preferably 5 mass% or less, relative to the total mass of the composition.

[0213] Therefore, the amount of the (e) second compound in the composition according to the present invention may be 0.001 mass% to 15 mass%, preferably 0.005 mass% to 10 mass%, more preferably 0.01 mass% to 5 mass%, relative to the total mass of the composition.

[0214] (e1) Polylysine The composition according to the present invention may comprise (e1) at least one polylysine. A single type of polylysine, or a combination of different types of polylysine can be used.

[0215] (e1) Polylysine corresponds to the condensation of several amino acids of lysine. (e1) Polylysine may be a natural homopolymer of L-lysine that can be produced by bacterial fermentation. Polylysine is typically used as a natural preservative in food products. Polylysine is a polyelectrolyte soluble in polar solvents such as water.

[0216] (e1) Polylysine may be, for example, epsilon-polylysine (or "ε-polylysine"), which is a condensation of the amino group at the ε position of lysine with a carboxyl group, or alpha-polylysine (or "α-polylysine"), which is a condensation of the amino group at the α position of lysine with a carboxyl group. (e1) Polylysine is commercially available in various forms such as poly-D-lysine and poly-L-lysine. (e1) Polylysine is generally a condensate of L-lysine, i.e., poly-L-lysine.

[0217] (e1) The molecular weight (Da) of polylysine is not limited, but may be less than 20,000, preferably less than 15,000, and more preferably less than 10,000.

[0218] (e1) The molecular weight (Da) of polylysine may be greater than 1,000, preferably greater than 1,500, and more preferably greater than 2,000.

[0219] Therefore, the molecular weight (Da) of (e1) polylysine may be greater than 1,000 and less than 20,000, preferably greater than 1,500 and less than 15,000, and more preferably greater than 2,000 and less than 10,000.

[0220] Unless otherwise defined in the description, "molecular weight" refers to the mass-average molecular weight. Molecular weight can be measured or determined by gel permeation chromatography, for example, in accordance with ASTM D5296-19.

[0221] (e1) Examples of polylysine include the following: - A 25% solution of epsilon-poly-L-lysine having a molecular weight of approximately 4,700 in aqueous solution, epsilon-poly-L-lysine from JNC CORPORATION; and - Polylysine from Shandong Freda Biotechnology, available in the form of a white to creamy yellow powder with a molecular weight between 4,130 and 5,776.

[0222] According to one particular embodiment, (e1) polylysine may be a modified polylysine, for example, a polylysine having a fatty acid chain as described in patent application FR 2889448, a polylysine having a guanidine or biguanidine functional group as described in patent application FR 2851465, or a thiolated polylysine as described in patent application FR 2853533.

[0223] (e1) Polylysine may be in the form of an organic or inorganic salt. Acid addition salts include, for example, hydrochloric acid or hydrobromic acid, sulfuric acid, citric acid, succinic acid, tartaric acid, lactic acid, para-toluenesulfonic acid, phosphoric acid, or acetate salts, or fatty acid salts such as linoleic acid, oleic acid, palmitic acid, stearic acid, behenic acid, and 18-methylicosanoic acid. Base addition salts include, for example, sodium salts, calcium salts, or hydroxyalkylamine salts, such as N-methylglucamine, aminopropanediol, or triethanolamine.

[0224] In some preferred embodiments of the present invention, (e1) polylysine exists in the form of a single molecule in the composition or is not covalently bonded to other compounds. In one embodiment of the present invention, (e1) polylysine is not covalently bonded to a dye compound. In one embodiment of the present invention, (e1) polylysine is not covalently bonded to a polyorganosiloxane compound. The term "polyorganosiloxane" is well known in the art and means a compound having a Si-O backbone and an organic functional group bonded to the backbone.

[0225] In another embodiment of the present invention, (e1) polylysine is in a free form. The term “free form” as used herein means that (e1) polylysine is not covalently bonded to any other compound.

[0226] The amount of (e1) polylysine in the composition according to the present invention may be 0.001% by mass or more, preferably 0.005% by mass or more, and more preferably 0.01% by mass or more, based on the total mass of the composition.

[0227] On the other hand, the amount of (e1) polylysine in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0228] Therefore, the amount of (e1) polylysine in the composition according to the present invention may be 0.001% to 15% by mass, preferably 0.005% to 10% by mass, and more preferably 0.01% to 5% by mass, based on the total mass of the composition.

[0229] (e2) Polysaccharide The composition according to the present invention may contain (e2) at least one polysaccharide. A single type of polysaccharide or a combination of different types of polysaccharides can be used.

[0230] (e2) The polysaccharide is preferably derived from natural resources such as plants and microorganisms.

[0231] (e2) It may be preferable that the polysaccharide is not derived from cellulose.

[0232] It is more preferable that the (e2) polysaccharide is biodegradable. The term "biodegradable" means that the (e2) polysaccharide can be broken down or divided in the environment or in living organisms, for example, by metabolism by microorganisms that may be present in the environment or in living organisms. Furthermore, biodegradable (e2) polysaccharides can be broken down by hydrolysis.

[0233] (e2) The polysaccharide may be nonionic or ionic, preferably ionic, more preferably cationic or anionic.

[0234] Cationic (e2) polysaccharides may have a positive charge density. The charge density of cationic (e2) polysaccharides may be 0.01 meq / g to 20 meq / g, preferably 0.05 meq / g to 15 meq / g, and more preferably 0.1 meq / g to 10 meq / g.

[0235] Anionic (e2) polysaccharides may have a negative charge density. The charge density of anionic (e2) polysaccharides may be 0.1 meq / g to 5.0 meq / g, preferably 0.2 meq / g to 4.0 meq / g, and more preferably 0.3 meq / g to 3.0 meq / g.

[0236] (e2) Examples of polysaccharides include chitosan, hyaluronic acid and its derivatives, and biopolysaccharides, which are described below.

[0237] Chitosan: (e2) The polysaccharide can be selected from chitosan.

[0238] In one embodiment, chitosan may have a low molecular weight.

[0239] The molecular weight (Da) of chitosan may be 1,000 or more, preferably 2,000 or more, and more preferably 3,000 or more. On the other hand, the molecular weight (Da) of chitosan may be less than 20,000, preferably less than 15,000, and more preferably less than 10,000.

[0240] Therefore, the molecular weight (Da) of the low molecular weight chitosan may be greater than 1,000 and less than 20,000, preferably greater than 2,000 and less than 15,000, and more preferably greater than 3,000 and less than 10,000.

[0241] In another embodiment, chitosan may have a high molecular weight.

[0242] The molecular weight (Da) of chitosan may be greater than 20,000, preferably greater than 50,000, and more preferably greater than 80,000. On the other hand, the molecular weight (Da) of chitosan may be less than 1,000,000, preferably less than 500,000, and more preferably less than 300,000.

[0243] Therefore, the molecular weight (Da) of the high molecular weight chitosan may be greater than 20,000 and less than 1,000,000, preferably greater than 50,000 and less than 500,000, and more preferably greater than 80,000 and less than 300,000.

[0244] Unless otherwise defined in the description, "molecular weight" refers to the mass-average molecular weight. Molecular weight can be measured or determined by gel permeation chromatography, for example, in accordance with ASTM D5296-19.

[0245] Chitosan is extremely rare in nature. It has only been reported in the exoskeleton of certain insects, such as termite queens, and in the cell walls of certain types of fungi, specifically those belonging to the class Zygomycetes.

[0246] Chitosan can be obtained by the deacetylation of chitin. Chitin is a polysaccharide composed of several N-acetyl-D-glucosamine units linked together by β-linkages (1,4).

[0247] The ideal chemical structure of chitosan is a sequence of β-D-glucosamine monomers joined by glycosidic bonds (1→4).

[0248] The "chitosan" according to the present invention refers to any copolymer formed from the constituent units N-acetyl-D-glucosamine and D-glucosamine, wherein the degree of acetylation is less than 90%, preferably less than 80%, preferably less than 70%, preferably less than 60%, and preferably less than 50%. Chitosan consists of glucosamine sugar units (deacetylated units) and N-acetyl-D-glucosamine units (acetylated units) linked together by β-type bonds (1,4), and is a poly(N-acetyl-D-glucosamine)-poly(D-glucosamine) type polymer.

[0249] More preferably, the degree of acetylation of chitosan is 40% or less, preferably 35% or less, preferably 25% or less, preferably 15% or less, and preferably 10% or less.

[0250] The degree of acetylation is the percentage of acetylated units relative to the total number of units, and can be determined by Fourier transform infrared spectroscopy (FT-IR) or titration with a strong base.

[0251] The chitosan of the present invention is preferably a polysaccharide prepared from a fungal source. In particular, it is extracted and purified from a safe and abundant food or biotechnologically derived fungal source, such as mushroom (Agaricus bisporus) or black mold (Aspergillus niger).

[0252] The chitosan of the present invention is preferably derived from fungi of the Ascomycete class, particularly Aspergillus and / or Basidiomycetes, specifically the mycelium of Lentinula edodes (shiitake) and / or button mushrooms. Preferably, the fungus is Aspergillus.

[0253] Chitosan may be of genetically modified organism (GMO) origin, but is preferably of non-GMO origin.

[0254] The chitosan according to the present invention is natural, that is, unmodified. In particular, it contains no chemical modifications whatsoever.

[0255] One method for preparing chitosan is described in WO03 / 068824.

[0256] Preferably, the chitosan used in the present invention is in powder form. It is commercially available from Kitozyme under the names Kiosmetine or Kionutrime, for example, Kiosmetine-CSH and Kiosmetine P.

[0257] Hyaluronic acid and its derivatives: (e2) The polysaccharide can be selected from hyaluronic acid and its derivatives.

[0258] Hyaluronic acid can be represented by the following chemical formula:

[0259] [ka]

[0260] In the context of this invention, the term "hyaluronic acid" specifically refers to the basic hyaluronic acid of the following formula.

[0261] [ka]

[0262] This is the smallest portion of hyaluronic acid, containing a disaccharide dimer, namely D-glucuronic acid and N-acetylglucosamine.

[0263] In the context of this invention, the term "hyaluronic acid" refers to a linear polymer comprising the polymer units described above, linked together in the chain via alternating β(1,4) and β(1,3) glucosidic bonds, having a molecular weight (Mw) that can range between 380 and 13,000,000 daltons. This molecular weight depends primarily on the source and / or preparation method from which the hyaluronic acid is obtained.

[0264] The term "hyaluronic acid" also includes hydrolyzed hyaluronic acid in the context of this invention.

[0265] In the context of this invention, the term "hyaluronic acid and its derivatives" includes hyaluronic acid salts. Examples of salts include alkali metal salts such as sodium and potassium salts, alkaline earth metal salts such as magnesium salts, ammonium salts, and mixtures thereof. Sodium hyaluronate is preferred.

[0266] The term "hyaluronic acid and its derivatives" also, in the context of the present invention, includes hyaluronic acid esters, in particular those in which all or part of the carboxylic acid groups of the acidic functional group are esterified with an oxyethylene alkyl or alcohol, and which contain 1 to 20 carbon atoms, and in particular those in which the degree of substitution at the level of D-glucuronic acid of hyaluronic acid is in the range of 0.5% to 50%.

[0267] In particular, methyl, ethyl, n-propyl, n-pentyl, benzyl, and dodecyl esters of hyaluronic acid can be mentioned. Such esters are described in detail in "Semisynthetic resorbable materials from hyaluronan esterification" by D. Campoccia et al., Biomaterials 19 (1998), pp. 2101-2127.

[0268] In one embodiment, the hyaluronic acid derivative may be, for example, acetylated hyaluronic acid or a salt thereof.

[0269] The term "hyaluronic acid and its derivatives" also includes cationic hyaluronic acid in the context of this invention.

[0270] Cationic hyaluronic acid contains at least one cationic moiety. The cationic moiety is -N + The cationic moiety may be a trialkylammonium group such as (CH3)3. The cationic moiety may contain at least one hydroxyl group. An example of a cationic group is -CH2-CH(OH)-CH2-N + (CH3)3 is one example.

[0271] An example of a cationic hyaluronic acid is hydroxypropyltrimonium hyaluronate.

[0272] The molecular weight of hyaluronic acid and its derivatives is not limited. The molecular weight of hyaluronic acid and its derivatives may be 5 kDa or more, preferably 20 kDa or more, and more preferably 100 kDa or more. The molecular weight of hyaluronic acid and its derivatives may be 20 MDa or less, preferably 10 MDa or less, and more preferably 2,000 kDa or less. Therefore, the molecular weight of hyaluronic acid and its derivatives may be 5 kDa to 20 MDa, preferably 20 kDa to 10 MDa, and more preferably 100 kDa to 2,000 kDa.

[0273] Unless otherwise defined in the explanation, "molecular weight" can refer to the mass-average molecular weight.

[0274] Hyaluronic acid or its derivatives, in particular, are supplied by Centipro under the trade name HyActive® (Mw: 10-150kDa), by Givaudan under the trade name Cristalhyal® (Mw: 1-1.4MDa), by Bioland under the trade name Nutra®HA (Mw: 907,600Da), by Bioland under the trade name Nutra®HAF (Mw: 74,600Da), by Bioland under the trade name Oligo®HA (Mw: 0.5-10.1kDa), by Res Pharma under the trade name D-Factor® (Mw: 380Da), or by Bloomage Freda Biopharm under the trade name Hybloom®Sodium Hyaluronate It may also be supplied under the product name (HA-T)(MW:1,000kDa~1,800kDa).

[0275] A single hyaluronic acid or its derivative having a single molecular weight, or a combination of two or more hyaluronic acids or their derivatives having different molecular weights, can be used.

[0276] It is preferable that hyaluronic acid or its derivatives be selected from hyaluronic acid salts, more preferably alkali metal hyaluronic acid salts, and even more preferably sodium hyaluronate.

[0277] Biopolysaccharides: In one embodiment, the (e2) polysaccharide can be selected from polysaccharides derived from microorganisms, known as biopolysaccharides.

[0278] Microbial polysaccharides or biopolysaccharides refer to polysaccharides produced by microorganisms such as pathogenic bacteria or other microorganisms. Microbial polysaccharides can be produced through the fermentation of sugars mediated by microorganisms.

[0279] Polysaccharides derived from microorganisms may contain units selected from mannose units, glucose units, and glucuronic acid units or galacturonic acid units within their chains, and these units may be acylated.

[0280] In particular, xanthan gum produced by the bacterium Xanthomonas campestris, as well as its variants and variants, can be mentioned.

[0281] Furthermore, scleroglucan gum produced by Sclerotium rolfsii, gellan gum produced by Pseudomonas elodea or Sphingomonias, pulllan gum produced by Aureobacidium pullulens, curdlan gum produced by Alcaligenes of the Faecalis myxogenes type, dextran gum produced by numerous organisms including Leuconostoc mesenteroides and Leuconostoc dextrantum, grifolan gum produced by Maitake mushroom (Grifola frondara), and lentinan gum produced by Shiitake mushroom (Lentinus edodes). Other examples include schizophyllan gum produced by Schizophyllum commine, spirulinan gum produced by Spirulina sybsyla, and cresting gum produced by Coriates versicolor.

[0282] The polysaccharides derived from microorganisms may be chemically modified at the discretion of the user.

[0283] According to certain embodiments of the present invention, polysaccharides derived from microorganisms are modified. In particular, nonionic guar gum modified with C1-C6 (poly)hydroxyalkyl groups can be cited.

[0284] Examples of hydroxyalkyl groups include hydroxymethyl, hydroxyethyl, hydroxypropyl, and hydroxybutyl groups.

[0285] These guar gums are well known in the prior art and can be prepared, for example, by reacting the guar gum with the corresponding alkene oxide, such as propylene oxide, to obtain guar gum modified with a hydroxypropyl group.

[0286] The degree of (poly)hydroxyalkylation corresponds to the number of alkylene oxide molecules consumed by the number of free hydroxyl functional groups present on the guar gum, and is preferably in the range of 0.4 to 1.2.

[0287] Nonionic guar gums optionally modified with such hydroxyalkyl groups are sold by Rhodia Chimie under trade names such as Jaguar HP8, Jaguar HP60 and Jaguar HP120, Jaguar DC 293, and Jaguar HP 105, or by Aqualon under the name Galactasol 4H4FD2.

[0288] Examples of polysaccharides derived from microorganisms include cardran, xanthan gum, gellan gum, dextran, pullulan, sclerotium gum, and mixtures thereof.

[0289] It may be preferable that the polysaccharide derived from microorganisms be selected from the group consisting of sclerotium gum, xanthan gum, and mixtures thereof.

[0290] (e2) The polysaccharide is preferably selected from chitosan, hyaluronic acid and its derivatives, polysaccharides derived from microorganisms, and mixtures thereof.

[0291] (e2) It is more preferable that the polysaccharide is selected from chitosan, hyaluronic acid and its salts, xanthan gum, and mixtures thereof.

[0292] (e2) It is even more preferable that the polysaccharide is selected from high molecular weight chitosan, hyaluronic acid and sodium hyaluronate, xanthan gum, and mixtures thereof.

[0293] The amount of (e2) polysaccharide in the composition according to the present invention may be 0.001% by mass or more, preferably 0.005% by mass or more, and more preferably 0.01% by mass or more, based on the total mass of the composition.

[0294] On the other hand, the amount of (e2) polysaccharide in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0295] Therefore, the amount of (e2) polysaccharide in the composition according to the present invention may be 0.001% to 15% by mass, preferably 0.005% to 10% by mass, and more preferably 0.01% to 5% by mass, based on the total mass of the composition.

[0296] (e3) Polyglutamates and their salts The composition according to the present invention may contain (e3) at least one polyamino acid or a salt thereof. A single type of polyamino acid or a salt thereof may be used, or two or more different types of polyamino acids or salts thereof may be used in combination.

[0297] (e3) The polyamino acid is preferably selected from polyglutamic acid. Therefore, component (e3) in the composition according to the present invention is preferably at least one polyglutamic acid or a salt thereof.

[0298] Polyglutamic acid or its salts have the following chemical formula (1): ROOC-CH2CH2-CH(-COOR)-NH-[CO-CH2CH2-CH(-COOR)-NH-] n -CO-CH2CH2-CH(-COOR)-NH2(1) [In the formula, R independently represents an alkali metal atom such as a hydrogen atom, a sodium atom, and a potassium atom, or an ammonium group such as a tetramethylammonium group and a tetraethylammonium group.] The chemical structure may be represented by [where n is an integer of 2 or greater, preferably 4 or greater, and more preferably 6 or greater].

[0299] The polyglutamic acid or its salt represented by the above chemical formula (1) may be called γ-polyglutamic acid or its salt because the carboxylic acid group at the γ position and the amino group at the α position form a peptide bond.

[0300] It is preferable that the polyglutamic acid or its salt has a molecular weight of 1000 or more and a degree of polymerization of 8 or more (where "n" in the above chemical formula (1) is 6 or more).

[0301] It may be more preferable that the polyglutamic acid or its salt has a molecular weight of 100,000 or more and a degree of polymerization of 770 or more (where "n" in the above chemical formula (1) is 768 or more).

[0302] It may be even more preferable that the molecular weight of the polyglutamic acid or its salt is 500,000 or more, and the degree of polymerization is 3840 or more (where "n" in the above chemical formula (1) is 3838 or more).

[0303] There is no upper limit to the molecular weight of polyglutamic acid or its salts.

[0304] However, the molecular weight of polyglutamic acid or its salt may be 5,000,000 or less, and the degree of polymerization may be 38,500 or less (where "n" in the above chemical formula (1) is 38,498 or less). Preferably, the molecular weight of polyglutamic acid or its salt may be 3,000,000 or less, and the degree of polymerization may be 23,080 or less (where "n" in the above chemical formula (1) is 23,078 or less).

[0305] The glutamic acid that constitutes polyglutamic acid or its salts may be D-form, L-form, or racemic. However, considering market availability, biocompatibility, and biodegradability, it may be preferable to use polyglutamic acid composed solely of L-form glutamic acid or a mixture of L-form and D-form glutamic acid. However, polyglutamic acid composed of D-form glutamic acid, which has the same effect but is less degradable, can also be used.

[0306] The method for producing polyglutamic acid or its salts is not particularly limited. For example, it can be produced by organic synthesis using a peptide synthesizer, organic synthesis by polymerization of glutamic acid N-carboxy anhydride, or organic synthesis by polymerization of N-benzyloxycarbonylglutamic acid anhydride. On the other hand, microorganisms belonging to the genus Bacillus that have the ability to produce γ-polyglutamic acid (in particular, Bacillus subtilis, Bacillus anthracis, Bacillus licheniformis, and Bacillus megaterium that have the ability to produce γ-polyglutamic acid) can also be used in fermentation methods for producing polyglutamic acid or its salts.

[0307] In addition to natural culture media composed of natural products such as shochu distillation wastewater culture media and soybean extract culture media, the following components are used as culture media in the fermentation method: Carbon sources such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol, and starch. Inorganic nitrogen sources such as ammonium sulfate, ammonium phosphate, and ammonium hydrochloride, Organic nitrogen sources such as glutamic acid or its salts, aspartic acid or its salts, Major inorganic salts such as sodium chloride, magnesium sulfate, monopotassium phosphate, phosphorus, and disodium hydrogen phosphate, Trace amounts of inorganic salts containing atoms such as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon, arsenic, vanadium, chromium, and fluorine. Vitamins such as biotin, nicotinamide, calcium pantothenate, thiamine, riboflavin, and pyridoxine hydrochloride. Organic acids such as citric acid, tartaric acid, malic acid, and glycolic acid, and Any synthetic medium or any semi-synthetic medium consisting of any one of the following natural product extracts: yeast extract, meat extract, potato extract, tomato extract, and soy peptide, It may be used at any concentration.

[0308] The microbial culture conditions may be set in the range of 20°C to 37°C in terms of temperature, and can be further controlled during the microbial growth process and the polyglutamic acid production process. The pH may be set in the range of 5.0 to 8.0, and can be further controlled during the microbial growth process and the polyglutamic acid production process.

[0309] After the completion of the culture, known methods such as acid precipitation, solvent precipitation, and membrane purification can be arbitrarily selected as methods for extracting and purifying polyglutamic acid or its salt from the culture medium.

[0310] It is preferable to use polyglutamic acid or its alkali metal salt, such as sodium polyglutamate, as the polyglutamic acid or its salt.

[0311] Commercially available products may be used as polyglutamic acid or its salts. Examples of polyglutamic acid or its salts include Hyafactor® PGA-HM, sold by Bloomage Biotechnology Co., Ltd. in China, and Bio-PGA Solution HE, HB, LB, and LE, as well as Bio PGA Na powder, sold by Ichimaru Falcos Co., Ltd. in Japan.

[0312] The amount of (e3) polyamino acids and / or salts thereof in the composition according to the present invention may be 0.001% by mass or more, preferably 0.005% by mass or more, and more preferably 0.01% by mass or more, based on the total mass of the composition.

[0313] On the other hand, the amount of (e3) polyamino acid or its salt in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0314] Therefore, the amount of (e3) polyamino acids and / or salts thereof in the composition according to the present invention may be 0.001% to 15% by mass, preferably 0.005% to 10% by mass, and more preferably 0.01% to 5% by mass, based on the total mass of the composition.

[0315] (e4) Protein The composition according to the present invention may contain (e4) at least one protein. A single type of protein may be used, or two or more different types of proteins may be used in combination.

[0316] (e4) The protein is preferably selected from plant-derived proteins. Therefore, component (e4) in the composition according to the present invention is preferably at least one plant-derived protein.

[0317] Plant-derived proteins may be polypeptides obtained from plants such as soybeans, peas, wheat, rice, corn, and sesame. The proteins may be subjected to hydrolysis. Hydrolysis may be carried out, for example, by conventionally known methods using acids or enzymes. Plant-derived proteins may also be polypeptides obtained through industrial biotechnology methods such as genetic modification and fermentation of natural, powerful carbon sources such as cornstarch.

[0318] The plant-derived protein may be selected from the group consisting of hydrolyzed pea protein, hydrolyzed soy protein, hydrolyzed wheat protein, hydrolyzed rice protein, hydrolyzed corn protein, plant-derived recombinant silk protein, and mixtures thereof.

[0319] The plant-derived protein is preferably hydrolyzed pea protein.

[0320] The protein may contain acidic amino acids such as aspartic acid and glutamic acid, as well as basic amino acids such as arginine, histidine, and lysine.

[0321] Hydrolyzed pea protein can be prepared by hydrolysis of peas (Pisum sativum L). Commercial products such as Promois® WJ or Promois® WJ-SP manufactured by Seiwa Kasei Co., Ltd., which are aqueous solutions or powdered pea proteins with an average molecular weight of approximately 500, may be used as hydrolyzed pea protein. Hydrolyzed soy protein can be prepared by hydrolysis of soybeans (Glycine max). Commercial products such as Promois® WS or Promois® WS-HSP manufactured by Seiwa Kasei Co., Ltd., which are aqueous solutions or powdered soy proteins with an average molecular weight of approximately 700, may be used as hydrolyzed soy protein. Hydrolyzed wheat protein can be prepared by hydrolysis of wheat (Triticum). As hydrolyzed wheat protein, commercially available products such as Promois® WG or Promois® WG-SP manufactured by Seiwa Kasei Co., Ltd., which are aqueous solutions or powdered wheat protein with an average molecular weight of approximately 700, may be used. Hydrolyzed rice protein can be prepared by hydrolysis of rice (Oryza sativa). As hydrolyzed rice protein, commercially available products such as Promois® WR or Promois® WR-SP manufactured by Seiwa Kasei Co., Ltd., which are aqueous solutions or powdered rice protein with an average molecular weight of approximately 400, may be used. As a mixture of hydrolyzed wheat protein, hydrolyzed corn protein, and hydrolyzed soy protein, commercially available products such as Keraplant manufactured by TRI-K, which are aqueous solutions of wheat protein, corn protein, and soy protein, may be used. As plant-derived silk, commercially available products such as Silkgel Neo® manufactured by Givaudan, which is an aqueous gel silk produced by industrial biotechnology using fermentation, may be used.

[0322] Since the protein can be obtained from plants, the present invention can be environmentally friendly.

[0323] The amount of (e4) protein in the composition according to the present invention may be 0.001% by mass or more, preferably 0.005% by mass or more, and more preferably 0.01% by mass or more, based on the total mass of the composition.

[0324] On the other hand, the amount of (e4) protein in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0325] Therefore, the amount of (e4) protein in the composition according to the present invention may be 0.001% to 15% by mass, preferably 0.005% to 10% by mass, and more preferably 0.01% to 5% by mass, relative to the total mass of the composition.

[0326] (Diol) The compositions according to the present invention may include (f) at least one diol having a total of five or six carbon atoms, with at least one carbon chain containing three or more carbon atoms. A single type of such diol or a combination of different types of such diols can be used.

[0327] In this specification, the term "diol" refers to a compound having two alcohol functional groups. In other words, a diol is an alcohol having two hydroxyl groups.

[0328] The number of carbon atoms in the carbon chain may be five or six.

[0329] (f) The carbon chain containing three or more carbon atoms in the diol may be linear or branched. The carbon chain must not be interrupted by heteroatoms, such as oxygen, sulfur, and nitrogen atoms. Therefore, the carbon chain may contain continuous carbon atoms.

[0330] (f) Preferably, the number of carbon chains containing three or more carbon atoms in the diol is one or two.

[0331] (f) The total number of carbon atoms in the diol is 5 or 6.

[0332] (f) Diols having a total of 5 or 6 carbon atoms and having at least one carbon chain containing 3 or more carbon atoms may have divalent linear or branched hydrocarbon groups. (f) Divalent linear or branched hydrocarbon groups that may be present in the diol may be saturated or unsaturated. (f) Diols having a total of 5 or 6 carbon atoms and having at least one carbon chain containing 3 or more carbon atoms preferably contain divalent linear or branched saturated hydrocarbon groups, more preferably linear or branched alkylene groups, such as propylene, pentylene and hexylene groups.

[0333] (f) A diol having a total of 5 or 6 carbon atoms and having at least one carbon chain containing 3 or more carbon atoms may have a linear, branched, or cyclic molecular structure, insofar as it has a carbon chain containing 3 or more carbon atoms and a total of 5 or 6 carbon atoms.

[0334] (f) Diols having a total of 5 or 6 carbon atoms, having at least one carbon chain containing 3 or more carbon atoms, include two hydroxyl groups. 5~6 It could be a diol.

[0335] (f) Preferably, a diol having a total of 5 or 6 carbon atoms and having at least one carbon chain containing 3 or more carbon atoms is selected from the group consisting of dipropylene glycol, pentylene glycol, hexylene glycol, and mixtures thereof.

[0336] (f) It is more preferable that the diol having a total of 5 or 6 carbon atoms, having at least one carbon chain containing 3 or more carbon atoms, is selected from the group consisting of pentylene glycol, hexylene glycol, and mixtures thereof.

[0337] The amount of (f)diol described above may be 0.1% by mass or more, preferably 0.5% by mass or more, and more preferably 1% by mass or more, based on the total mass of the composition.

[0338] On the other hand, the amount of the above-mentioned (f) diol may be 35% by mass or less, preferably 30% by mass or less, and more preferably 25% by mass or less, based on the total mass of the composition.

[0339] Therefore, the amount of (f) diol mentioned above may be 0.1% to 35% by mass, preferably 0.5% to 30% by mass, and more preferably 1% to 25% by mass, relative to the total mass of the composition.

[0340] (water) The composition according to the present invention may contain (g) water.

[0341] (g) The amount of water may be 50% by mass or more, preferably 55% by mass or more, and more preferably 60% by mass or more, based on the total mass of the composition.

[0342] On the other hand, the amount of (g) water may be 99% by mass or less, preferably 98% by mass or less, and more preferably 97% by mass or less, relative to the total mass of the composition.

[0343] Therefore, the amount of (g) water may be 50% to 99% by mass, preferably 55% to 98% by mass, and more preferably 60% to 97% by mass, relative to the total mass of the composition.

[0344] (Monovalent nonpolymeric acid or its salt) The composition according to the present invention may (h) contain at least one monovalent nonpolymeric acid or a salt thereof. A single type of monovalent nonpolymeric acid or a salt thereof, or a combination of different types of monovalent nonpolymeric acids or salts thereof, can be used.

[0345] In this specification, the term "non-polymer" means that the acid is not obtained by polymerizing two or more monomers. Therefore, non-polymer acids do not correspond to acids obtained by polymerizing two or more monomers, such as polyacrylic acid.

[0346] In this specification, the term "salt" means a salt formed by adding a suitable base to a monovalent nonpolymeric acid, which can be obtained from the reaction of a monovalent nonpolymeric acid with a base according to methods known to those skilled in the art. Examples of salts include metal salts, such as salts with alkali metals like Na and K, and salts with alkaline earth metals like Mg and Ca, as well as ammonium salts.

[0347] (h) The molecular weight of the monovalent nonpolymeric acid or its salt is preferably less than 1000, preferably 500 or less, and more preferably 200 or less.

[0348] (h) A monovalent nonpolymeric acid or a salt thereof may be included in the aqueous phase formed by (g) water. (h) A monovalent nonpolymeric acid or a salt thereof can promote the dissolution of (e2) polysaccharides, preferably chitosan, more preferably high molecular weight chitosan, for example, in water.

[0349] (h) A monovalent nonpolymeric acid has a single acid group which can be selected from the group consisting of a carboxylic acid group, a sulfate group, a sulfonic acid group, a phosphoric acid group, a phosphonic acid group, and mixtures thereof.

[0350] (h) A monovalent nonpolymeric acid or a salt thereof may be selected from monovalent organic or inorganic acids and their salts.

[0351] (h) The monovalent nonpolymeric acid is preferably a monovalent organic acid, more preferably a monovalent nonpolymeric carboxylic acid.

[0352] The monovalent nonpolymeric carboxylic acid can be selected from hydroxy acids, preferably alpha-hydroxy acids and beta-hydroxy acids. Examples of alpha-hydroxy acids include lactic acid and glycolic acid. Examples of beta-hydroxy acids include salicylic acid.

[0353] Therefore, the monovalent nonpolymeric acid may be a monovalent nonpolymeric organic acid, preferably a monovalent nonpolymeric carboxylic acid, and more preferably a monovalent hydroxy acid, such as lactic acid and salicylic acid.

[0354] The amount of (h) a monovalent nonpolymeric acid or a salt thereof in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more, based on the total mass of the composition.

[0355] On the other hand, the amount of (h) a monovalent nonpolymeric acid or a salt thereof in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0356] Therefore, the amount of (h) monovalent nonpolymeric acid or its salt in the composition according to the present invention may be 0.01% to 15% by mass, preferably 0.05% to 10% by mass, and more preferably 0.1% to 5% by mass, based on the total mass of the composition.

[0357] (pH) The pH of the composition according to the present invention may be 3 to 9, preferably 3.3 to 8.5, and more preferably 3.5 to 8.

[0358] The pH of the composition according to the present invention can be adjusted by adding at least one alkaline agent and / or at least one acid. The pH of the composition according to the present invention can also be adjusted by adding at least one buffering agent.

[0359] (Optional additives) In addition to the components described above, the compositions according to the present invention may also contain components typically used in cosmetics, specifically cationic, anionic, amphoteric, or nonionic nonnatural surfactants or emulsifiers; hydrophilic thickeners (other than (e2) polysaccharides); lipophilic thickeners; hydrophilic or lipophilic antioxidants; volatile or nonvolatile organic solvents; silicones; natural extracts derived from animals or plants, etc., to the extent that they do not impair the effects of the present invention.

[0360] The composition according to the present invention may contain the above-mentioned optional additives in an amount of 0.01% to 30% by mass, preferably 0.05% to 20% by mass, and more preferably 0.1% to 10% by mass, based on the total mass of the composition.

[0361] The composition according to the present invention may contain a very limited amount of non-natural surfactant or emulsifier, taking environmental compatibility into consideration.

[0362] The amount of non-natural surfactant or emulsifier in the composition according to the present invention may be 1% by mass or less, preferably 0.1% by mass or less, and more preferably 0.01% by mass or less, based on the total mass of the composition. It is particularly preferable that the composition according to the present invention does not contain non-natural surfactant or emulsifier.

[0363] The composition according to the present invention may contain a very limited amount of silicone, taking environmental compatibility into consideration.

[0364] The amount of silicone in the composition according to the present invention may be 1% by mass or less, preferably 0.1% by mass or less, and more preferably 0.01% by mass or less, based on the total mass of the composition. It is particularly preferable that the composition according to the present invention does not contain silicone.

[0365] (Embodiment) According to a preferred embodiment, the composition according to the present invention is, with respect to the total mass of the composition, (a) at least one ceramide-type compound in an amount of 0.001% to 15% by mass, (b) at least one glycolipid in an amount of 0.01% to 20% by mass, and (c) At least one type of oil in less than 5% by mass Includes.

[0366] According to a more preferred embodiment, the composition according to the present invention is, with respect to the total mass of the composition, 0.005% to 10% by mass of (a') at least one ceramide-type compound represented by formula (I) above, (b') 0.1% to 15% by mass of at least one glycolipid selected from rhamnolipids, sophorolipids, and mixtures thereof, and (c) Contains less than 3% by mass of at least one type of oil.

[0367] In a more preferred embodiment, the composition according to the present invention, with respect to the total mass of the composition, 0.01% to 5% by mass of (a) ceramide AP and / or ceramide NP, (b') At least one glycolipid selected from rhamnolipids, sophorolipids, and mixtures thereof in an amount of 1% to 10% by mass, and (c) Contains less than 1% by mass of at least one type of oil.

[0368] (preparation) The composition according to the present invention can be prepared by mixing the essential components described above with the optional components (if necessary) described above.

[0369] The methods and means for mixing the above-mentioned essential components and optional components are not limited. Any conventional methods and means may be used to mix the above-mentioned essential components and optional components to prepare the compositions according to the present invention.

[0370] The compositions according to the present invention can be prepared by simply or easily mixing using conventional mixing means such as a stirrer and a homogenizer. Heating may not be necessary. Therefore, the method for preparing the compositions according to the present invention may be environmentally friendly.

[0371] In one embodiment, the composition according to the present invention is (i) A step of preparing a diol solution by mixing (a) at least one ceramide-type compound, (b) at least one glycolipid, and (d) at least one first compound (if present) selected from the group consisting of (d1) fatty acids, (d2) aliphatic alcohols, and mixtures thereof, and (f) at least one diol having a total of 5 or 6 carbon atoms and having at least one carbon chain containing 3 or more carbon atoms; (ii) (e) A step of preparing an aqueous solution by mixing (g) water with at least one second compound selected from the group consisting of (e1) polylysine, (e2) polysaccharides, (e3) polyamino acids and their salts, (e4) proteins, and mixtures thereof, (iii) A step of preparing the composition according to the present invention by adding the diol solution obtained in step (i) to the aqueous solution obtained in step (ii). It can be prepared by a method that includes [a specific component].

[0372] The above process can be carried out, for example, at room temperature (2°C) or at a high temperature, such as 30°C to 90°C.

[0373] The above method may include an additional step (iv) of adding (c) at least one oil (if present) to the composition prepared by step (iii) above, provided that the amount of (c) oil is less than 5% by mass, preferably less than 3% by mass, and more preferably less than 1% by mass, based on the total mass of the composition.

[0374] (Beauty use) The compositions according to the present invention may be intended for use as cosmetic compositions. Therefore, the cosmetic compositions according to the present invention may be intended for application on keratinous materials. In this specification, keratinous materials mean substances that contain keratin as a main component, and examples include skin, scalp, nails, lips, hair, etc. The cosmetic compositions according to the present invention are preferably used for cosmetic methods for keratinous materials, particularly skin.

[0375] The compositions according to the present invention can preferably be used as cosmetic compositions, more preferably as cosmetic compositions for keratin substances, and even more preferably as skin cosmetic compositions for skin care.

[0376] (form) The composition according to the present invention may exist in any form.

[0377] For example, the composition according to the present invention may be in the form of a solution, particularly an aqueous solution, or a dispersion or emulsion, particularly an aqueous dispersion or O / W emulsion.

[0378] [Beauty methods and usage] The present invention also, A cosmetic method for keratinous substances in the skin, etc. Steps of applying the composition according to the present invention to a keratin substance. This also includes information about beauty methods.

[0379] When the composition according to the present invention is applied to a keratinous substance such as skin, the microsheet structure in the composition can easily adhere to the keratinous substance, and therefore, components such as (a) ceramide-type compounds of the microsheet structure can be effectively applied to the keratinous substance.

[0380] In this specification, "beauty treatment" refers to non-therapeutic beauty treatments for beautifying keratinous substances such as skin.

[0381] The present invention may also relate to the use of the composition according to the present invention as a cosmetic, such as a skin care product, or in a cosmetic.

[0382] In other words, the composition according to the present invention can be used as a cosmetic as is. Alternatively, the composition according to the present invention can be used as an element of a cosmetic. For example, the composition according to the present invention can be added to or combined with any other element to form a cosmetic.

[0383] For example, skincare products may include lotions and serums.

[0384] The present invention also, (a) at least one ceramide-type compound (b) the use of at least one glycolipid in a composition comprising, The amount of (c) oil in the composition is less than 5% by mass, preferably less than 3% by mass, and more preferably less than 1% by mass, based on the total mass of the composition. For stabilizing the composition, and especially preferably for stably dissolving or dispersing (a) the ceramide-type compound in the composition without aggregation of the ceramide-type compound, and / or (a) To form at least one microsheet structure containing a ceramide-type compound, It may also affect usage.

[0385] This invention also (a) at least one ceramide-type compound, and (b) at least one glycolipid (c) the use of at least one oil in a composition containing, The amount of (c) oil in the composition is less than 5% by mass, preferably less than 3% by mass, and more preferably less than 1% by mass, based on the total mass of the composition. For stabilizing the composition, and especially preferably for stably dissolving or dispersing (a) the ceramide-type compound in the composition without aggregation of the ceramide-type compound, and / or (a) To form at least one microsheet structure containing a ceramide-type compound, It may also affect usage.

[0386] The composition used in the above-mentioned applications is preferably, (d) At least one first compound selected from the group consisting of (d1) fatty acids, (d2) aliphatic alcohols, and mixtures thereof. It may include, more, (d) At least one first compound selected from the group consisting of (d1) fatty acids, (d2) aliphatic alcohols, and mixtures thereof, (e) At least one second compound selected from the group consisting of (e1) polylysine, (e2) polysaccharides, (e3) polyamino acids and their salts, (e4) proteins, and mixtures thereof. Includes.

[0387] The composition in the above use according to the present invention may further contain (f) at least one diol having a total of 5 or 6 carbon atoms, having at least one carbon chain containing 3 or more carbon atoms, and / or (g) water.

[0388] The above description of (a) ceramide-type compounds, (b) glycolipids, (c) oils, and other possible components for compositions according to the present invention can also be applied to those in compositions in the above-described use according to the present invention. [Examples]

[0389] The present invention will be described in more detail by reference to examples. However, these should not be construed as limiting the scope of the present invention.

[0390] (Examples 1-11 and Comparative Examples 1-4) [Preparation] Each of the compositions from Examples 1-11 and Comparative Examples 1-4 was prepared by mixing the components shown in Tables 1-2 below. All numerical values ​​for the amounts of components in Tables 1-2 below are based on the "mass%" of the raw materials.

[0391] The details of the preparation are as follows:

[0392] A pentylene glycol solution was prepared by mixing ceramide, glycolipids (if present), and fatty acids or aliphatic alcohols (if present) with pentylene glycol (1,2-pentanediol) using a magnetic stirrer at 80°C for 15 minutes. Meanwhile, aqueous solutions were prepared by mixing the other components with water.

[0393] Pentylene glycol solution was added dropwise to an aqueous solution using a dispenser at 2000 rpm for 10 minutes while stirring at 80°C, and then cooled to room temperature (25°C) to obtain the compositions according to Examples 1-11 and Comparative Examples 1-3.

[0394] For Comparative Example 4, squalene as an oil was added to the aqueous solution together with the pentylene glycol solution at 80°C while stirring with a dispenser at 2000 rpm for 10 minutes, and then cooled to room temperature (25°C) to obtain the composition according to Comparative Example 4.

[0395] [Table 2]

[0396] [Table 3]

[0397] [evaluation] (stability) Each of the compositions prepared in Examples 1-11 and Comparative Examples 1-4 was stored in a transparent container at room temperature (25°C) immediately after preparation. The stability of each composition was observed visually and evaluated according to the following criteria. Good: No aggregation or precipitation was observed, or only slight aggregation or precipitation was observed. Poor performance: Aggregation or precipitation was observed.

[0398] The results are shown in Tables 1 and 2 below.

[0399] (Observation using a microscope) The compositions from Examples 1-11 and Comparative Examples 1-4 were each subjected to microscopic observation at room temperature (25°C) immediately after preparation. Micrographs of each composition from Examples 1-11 and Comparative Examples 1-4 were obtained and observed. The fine structures in each micrograph were identified and characterized by the following symbols. LS: Large seat SS: Small seat A / F: Aggregates / Foam C: Crystal A / O: Separation of aggregates / oil

[0400] The results are shown in Tables 1 and 2 below.

[0401] Microscopic images obtained by microscopic observation of the compositions according to Examples 1, 2, 4, and 5 are shown in Figures 1 to 4, respectively. It is clear that composites in the form of large or small sheets have been formed.

[0402] No sheet-like microstructures were found in the compositions of Comparative Examples 1-4.

[0403] (summary) The compositions from Examples 1-11 were stable enough that no aggregation or precipitation was observed. Furthermore, the compositions from Examples 1-11 contained microsheet structures.

[0404] The composition according to Comparative Example 1, which contained no glycolipids at all, was unstable. Furthermore, the composition according to Comparative Example 1 did not contain a microsheet structure.

[0405] The composition according to Comparative Example 2, which contained safflower glucoside instead of glycolipids, was unstable. Furthermore, the composition according to Comparative Example 2 did not contain a microsheet structure.

[0406] The composition of Comparative Example 3, which contained safflower glucoside instead of glycolipids and also contained sodium hyaluronate, was unstable. Furthermore, the composition of Comparative Example 3 did not contain a microsheet structure. Comparative Example 3 should be compared with Example 2.

[0407] The composition according to Comparative Example 4, which contained a considerable amount of oil (squalane), was unstable. Furthermore, the composition according to Comparative Example 4 did not contain a microsheet structure.

Claims

1. (a) at least one ceramide-type compound, and (b) at least one glycolipid A composition comprising, preferably a cosmetic composition, more preferably a skin cosmetic composition, A composition in which the amount of (c) oil in the composition is less than 5% by mass, preferably less than 3% by mass, and more preferably less than 1% by mass, based on the total mass of the composition.

2. (a) The ceramide-type compound is given by the following formula (I): 【Chemistry 1】 [In the formula, - R 1 C is a linear or branched saturated or unsaturated hydrocarbon group. 1 ~C 50 Preferably C 5 ~C 50 This represents a group which may be substituted with one or more hydroxyl groups and / or optionally interrupted with one or more oxycarbonyl (-O-CO-) groups or carbonyloxy (-CO-O-) groups. - R 2 represents a linear or branched, saturated or unsaturated hydrocarbon group C 1 to C 50 , preferably C 5 to C 50 , which group may be substituted with one or more hydroxyl groups, and / or may optionally be interrupted by one or more oxycarbonyl (-O-CO-) groups or carbonyloxy (-CO-O-) groups] The composition according to claim 1, as represented by [the specified figure].

3. The composition according to claim 1 or 2, wherein the amount of (a) ceramide-type compound in the composition is 0.001% to 10% by mass, preferably 0.005% to 5% by mass, and more preferably 0.01% to 1% by mass, based on the total mass of the composition.

4. (b) The composition according to any one of claims 1 to 3, wherein the glycolipid is selected from rhamnolipid, sophorolipid, and mixtures thereof, preferably from rhamnolipid.

5. The composition according to any one of claims 1 to 4, wherein the amount of (b) glycolipid in the composition is 0.01% to 20% by mass, preferably 0.1% to 15% by mass, and more preferably 1% to 10% by mass, based on the total mass of the composition.

6. The composition according to any one of claims 1 to 5, further comprising (d) at least one first compound selected from the group consisting of (d1) fatty acids, (d2) aliphatic alcohols, and mixtures thereof.

7. (d1) Fatty acids, C 4 ~C 24 Preferably C 6 ~C 22 , more C 8 ~C 20 The composition according to claim 6, selected from saturated or unsaturated linear or branched fatty acids.

8. (d2) The composition according to claim 6 or 7, wherein the aliphatic alcohol is selected from the group consisting of cetyl alcohol, cetearyl alcohol, stearyl alcohol, behenyl alcohol, oleyl alcohol, and mixtures thereof.

9. The composition according to any one of claims 6 to 8, wherein the amount of (d) the first compound in the composition is 0.01% to 15% by mass, preferably 0.05% to 10% by mass, and more preferably 0.1% to 5% by mass, based on the total mass of the composition.

10. The composition according to any one of claims 1 to 9, further comprising (e) at least one second compound selected from the group consisting of (e1) polylysine, (e2) polysaccharides, (e3) polyamino acids and salts thereof, (e4) proteins, and mixtures thereof.

11. (e2) The composition according to claim 10, wherein the polysaccharide is selected from the group consisting of chitosan, hyaluronic acid and its derivatives, polysaccharides derived from microorganisms, and mixtures thereof, preferably selected from the group consisting of chitosan, hyaluronic acid and its salts, xanthan gum, and mixtures thereof, more preferably selected from the group consisting of chitosan, sodium hyaluronate, xanthan gum, and mixtures thereof.

12. (e3) The composition according to claim 10 or 11, wherein the polyamino acid is selected from polyglutamic acid.

13. (e4) The composition according to any one of claims 10 to 12, wherein the protein is derived from a plant.

14. The composition according to any one of claims 10 to 13, wherein the amount of (e) the second compound in the composition is 0.001% to 15% by mass, preferably 0.005% to 10% by mass, and more preferably 0.01% to 5% by mass, based on the total mass of the composition.

15. A cosmetic method for keratinous substances in the skin, etc. A step of applying the composition according to any one of claims 1 to 14 to a keratin substance. Beauty methods, including

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