Multiple SFLT-1 measurements for the prognosis of early-onset preeclampsia

Abstract

The present invention relates to a method for prognosing, predicting, risk assessment, and / or risk stratifying preeclampsia in a pregnant subject, comprising determining the level of soluble fms-like tyrosine kinase-1 (sFlt-1) or a fragment thereof in a sample isolated from the pregnant subject. The present invention further relates to a method for prognosing, predicting, risk assessment, and / or risk stratifying early-onset preeclampsia in a pregnant subject. The present invention relates to a combined measurement of sFlt-1 and PlGF, optionally in combination taking into account one or more additional factors selected from maternal age, body mass index, uterine artery Doppler measurement, and / or mean arterial pressure (MAP). The present invention further relates to a kit for carrying out the method of the present invention, comprising detection reagents for determining the level of sFlt-1 or a fragment thereof in a sample from the subject, and optionally for determining the level of at least one additional biomarker described herein.

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