UTRs and their uses for improving translation efficiency and / or stability of RNA molecules
JP2026501176APending Publication Date: 2026-01-14SHENZHEN SHENXIN BIOTECHNOLOGY CO LTD
Patent Information
- Application Number
- JP2025534775
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-12-16
- Filing Date
- 2023-12-15
- Publication Date
- 2026-01-14
Smart Images
Figure 2026501176000012 
Figure 2026501176000013 
Figure 2026501176000014
Abstract
Recombinant RNA molecules are provided that contain a nucleotide sequence encoding a polypeptide of interest and a 5'-UTR and / or a 3'-UTR. The RNA molecules exhibit improved translation efficiency and / or stability, resulting in increased polypeptide and / or protein expression levels. Also provided are vectors encoding the recombinant RNA molecules, pharmaceutical compositions containing the recombinant RNA molecules, and methods for treating or preventing disease using the recombinant RNA molecules.
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Citation Information
Patent Citations
Polynucleotide, composition and method for genome editing
CN111405912A
HETEROLOGOUS UTR SEQUENCES FOR ENHANCED mRNA EXPRESSION
WO2017100551A1