Pulsed low-dose-rate intensity-modulated proton therapy for reirradiation of central nervous system malignancies
Pulsed low-dose-rate intensity-modulated proton therapy addresses the limitations of current intracranial malignancy treatments by improving response and survival rates with reduced toxicity through controlled proton pulse delivery.
JP2026506898APending Publication Date: 2026-02-27BAPTIST HEALTH SOUTH FLORIDA INC
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Patent Information
- Application Number
- JP2025546068
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-02-09
- Filing Date
- 2024-02-09
- Publication Date
- 2026-02-27
AI Technical Summary
Technical Problem
Current treatment options for intracranial malignancies, such as glioblastoma, fail to improve response rates and overall survival while effectively managing toxicity, particularly in re-irradiation therapies.
Method used
A method and system utilizing pulsed low-dose-rate intensity-modulated proton therapy (PRDR-IMPT) to deliver therapeutic pulses to tumors, with a controlled temporal interval between proton pulses, modulating doses to spare critical structures and reduce toxicity.
Benefits of technology
Enhances tumor response and overall survival with reduced toxicity by leveraging the radiobiological advantages of protons, minimizing damage to healthy tissues, and allowing for higher tumor doses without severe side effects.
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Figure 2026506898000001_ABST
Abstract
The method for re-treating a tumor includes providing treatment pulses to the tumor according to a pulsed low dose rate (PRDR) treatment pattern. The treatment pulses are PRDR intensity-modulated proton therapy (IMPT) pulses that include proton pulses delivered to the tumor. A system for re-treating a tumor is also disclosed, the system including a first sub-beam emitter that provides a first plurality of intensity-modulated proton therapy (IMPT) pulses according to the pulsed low dose rate (PRDR) treatment pattern and a second sub-beam emitter that provides a second plurality of intensity-modulated proton therapy (IMPT) pulses according to the PRDR treatment pattern. The system also includes a controller configured to sequentially deliver the first plurality of IMPT pulses and the second plurality of IMPT pulses to the tumor with a temporal interval between pulse deliveries.
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