High-throughput drug screening method based on imaging flow cytometry

JP2026507753APending Publication Date: 2026-03-05FAIRY LIFE SCIENCES (WUHAN) CO LTD
View PDF 0 Cites 0 Cited by

Patent Information

Application Number
JP2025568958
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-02-14
Filing Date
2023-10-07
Publication Date
2026-03-05

AI Technical Summary

Technical Problem

Conventional cell phenotyping drug screening methods lack high-throughput capabilities due to the limitations of flow cytometers in capturing two-dimensional spatial resolution and cellular morphological information, and fluorescence microscopes are inefficient with limited cell counts per field of view.

Method used

A high-throughput drug screening method using imaging flow cytometry that combines flow technology with high-speed microscopy to generate multi-channel single-cell images, incorporating fluorescent marking and AI analysis to extract cellular information and select drugs based on specified conditions.

Benefits of technology

Enhances drug screening efficiency by 102-104 times, enabling accurate analysis of cellular components, organelles, and drug effects through multi-channel imaging and AI-driven data processing.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 2026507753000001_ABST
    Figure 2026507753000001_ABST
Patent Text Reader

Abstract

The present invention relates to the field of drug screening, specifically to a high-throughput drug screening method based on imaging flow cytometry. The high-throughput drug screening method provided by the present invention includes cell culture, cell staining, single-cell image acquisition by a flow cytometer, image extraction, and analysis. This method combines the high-throughput advantages of flow cytometry with the imaging capabilities of a microscope to generate multi-channel single-cell images at high throughput, achieving the collection of fluorescent and unmarked images of single cells at a throughput of 102-105 cells / second, which can be used for cell phenotype drug screening, improving screening efficiency by 102-104 times.
Need to check novelty before this filing date? Find Prior Art