Sunscreen composition containing human milk oligosaccharides

Abstract

The present invention relates to an emulsion containing at least one UVA sunscreen activator and having improved sun protection index (SPF) properties, and to a method for improving sun protection index (SPF) properties.

Description

Detailed description of the invention

[0001] The present invention relates to a composition containing at least one UVA sunscreen activator and having improved sun protection index (SPF) properties, and to a method for improving sun protection index (SPF) properties.

[0002] The use of compositions containing UV sunscreen activators (also called sunscreens) is very common today. Sunscreen activators in such compositions protect keratinous substances, particularly skin, from damage caused by UV rays, including damage from both UVA and UVB rays.

[0003] UVA rays have the lowest energy of all UV rays. These rays cause aging of skin cells and can indirectly damage the DNA of cells. UVA rays are mainly associated with long-term skin damage such as wrinkles, but are also thought to play a role in some skin cancers. UVB rays have shorter wavelengths. UVB radiation is associated not only with skin burns but also with skin cancer. Unprotected exposure to UVA and UVB rays damages the DNA of skin cells, causing genetic defects or mutations that can lead to skin cancer and premature aging.

[0004] Therefore, the need for sunscreens that offer high levels of UVA and UVB protection is increasing in order to achieve ultimate skin protection.

[0005] The standard measure for determining the amount of protection a composition containing sunscreen activators provides against UV radiation is the sun protection factor (SPF). However, given the limited number of sunscreen activators approved worldwide, increasing the SPF of compositions containing sunscreen activators can be challenging.

[0006] Therefore, there is still a need for preferably natural ingredients that can increase the SPF of the sunscreen active ingredients in the composition.

[0007] Surprisingly, it was found that certain human milk oligosaccharides can significantly increase the SPF of compositions containing certain UVA filters when combined with UVB and / or broadband UV filters.

[0008] Accordingly, in the first embodiment, the present invention relates to a composition for keratinous substances (e.g., hair or skin) comprising at least one UVA filter selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate, and at least one sialylated human milk oligosaccharide. Preferably, the composition is in oil-in-water form (O / W emulsion).

[0009] The present invention also relates to a method for enhancing the sun protection index (SPF) properties of a composition comprising at least one UVA filter selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate, the method comprising adding at least one sialylated human milk oligosaccharide to the composition in an amount effective for enhancing the SPF properties of the composition.

[0010] The present invention also relates to the use of sialylated human milk oligosaccharides to enhance the sun protection index (SPF) of a composition comprising at least one UVA filter selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate.

[0011] The present invention also relates to a method for preparing a composition having improved sun protection index (SPF) properties, comprising adding to the composition, during the preparation of the composition, at least one UVA filter selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate, and at least one sialylated human milk oligosaccharide. It is well understood that the improved properties are compared to a composition without sialylated human milk oligosaccharides having all the definitions and preferences given herein.

[0012] The present invention further relates to a method for producing a composition, the method comprising combining at least one UVA filter selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate with at least one sialylated human milk oligosaccharide in the composition.

[0013] The use of the composition of the present invention as a sunscreen composition for protecting the skin from the effects of skin aging, particularly wrinkles (especially from UV-induced skin aging), and for sun protection, is also in accordance with the present invention.

[0014] Finally, the subject matter of the present invention is a method for the cosmetic treatment of keratinous substances, particularly skin, where compositions as defined herein are applied particularly to such keratinous substances, particularly skin. This method is particularly suitable for protecting the skin from the harmful effects of ultraviolet radiation, such as sunburn and / or photoaging.

[0015] The terms “UV filter” and “sunscreen activator” are used interchangeably herein and refer to compounds that absorb light in the UVB and / or UVA range (also known as UVA, UVB and broadband (i.e., UVA & UVB) filters). Preferably, such compounds have an E1 / 1 value of at least 150, more preferably at least 180, and most preferably at least 190 (i.e., λ max It has a UV absorbance of 1% at a concentration with an absorption layer thickness of 1 cm.

[0016] The term "keratinous material" means skin (body, face, eye contours, scalp), hair, eyelashes, eyebrows, body hair, nails, and / or lips. Preferably, in all embodiments, the keratinous material is skin.

[0017] The term "human milk oligosaccharides (HMOs)" refers to a family of unconjugated glycans that are very abundant in human breast milk and possess unique structural diversity. Originally, HMOs were found to promote the growth of Bifidobacterium species in the gut and are proposed to be prebiotic "bifidobacterial factors" or human milk glycans that are uniquely found in the stool of breastfed infants compared to infants fed formula.

[0018] Butyl methoxydibenzoylmethane (CAS number: 70356-09-1; abbreviated as BMDBM), also known as avobenzone, is sold, for example, by DSM Nutritional Products Ltd. under the trade name "Parsol® 1789".

[0019] Diethylaminohydroxybenzoyl hexyl benzoate (CAS number: 302776-68-7; abbreviated as DHHB), also known as hexyl 2-[4-(diethylamino)2-hydroxybenzoyl]benzoate, is sold, for example, by BASF under the trade name Uvinul® A plus.

[0020] The SPF according to the present invention is understood to be measured by the in vitro SPF method outlined in ISO 24443 (Determination of sunscreen UVA photoprotection in vitro, 01.06.2012) and illustrated in the examples.

[0021] HMOs generally consist of five monosaccharides: glucose (Glc), galactose (Gal), N-acetylglucosamine (GlcNAc), fucose (Fuc), and sialic acid (Sia), primarily along with N-acetylneuraminic acid (Neu5Ac) if sialic acid (Sia) is not the only form. More than 200 different HMOs have been identified to date, but among the most important are 3'-sialyl lactose sodium salt (3'SL) and 6'-sialyl lactose sodium salt (6'SL).

[0022] HMO can be isolated from breast milk or produced chemically or biochemically. HMOs are available from various manufacturers.

[0023] For the purposes of the present invention, the source of sialylated HMO is not essential. It is clear that HMOs from various sources can be used.

[0024] Particularly preferred sialylated HMOs according to the present invention are sialyllactose and its salts (preferably the sodium salt), for example, in particular 3'sialyllactose (3'SL), 6'sialyllactose (6'SL) and their respective sodium salts (CAS numbers: 35890-39-2 (3'sialyllactose); 128596-80-5 (3'sialyllactose sodium salt); 35890-39-2 (6'sialyllactose); 157574-76-0 (6'sialyllactose sodium salt)).

[0025] The total amount of HMO according to the present invention in the composition according to the present invention is preferably at least 0.01 w% by weight, more preferably at least 0.1% by weight, even more preferably at least 0.2% by weight, for example at least 0.3% by weight or at least 0.5% by weight, based on the total weight of the composition. In particular, the total amount of at least one HMO according to the present invention in the composition according to the present invention is preferably selected in the range of 0.01 to 10% by weight, more preferably in the range of 0.1 to 7.5% by weight, most preferably in the range of 0.2 to 5% by weight, based on the total weight of the composition. Further suitable ranges are 0.25 to 5% by weight, 0.5 to 4% by weight, 0.1 to 3% by weight, 0.25 to 3% by weight and 0.3 to 3% by weight. Particularly preferred ranges according to the present invention are 0.1 to 5% by weight, more preferably 0.25 to 3% by weight, for example 0.25 to 1.5% by weight or 0.5 to 5% by weight, or 0.5 to 4% by weight.

[0026] It is well understood that the composition according to the present invention may contain one or more sialylated HMOs. However, preferably, in all embodiments of the present invention, the composition according to the present invention contains only one or two, more preferably only one sialylated HMO, for example, most preferably only one HMO selected from 3’SL and 6’SL, particularly in the form of their sodium salts. The most preferred sialylated HMO in all embodiments of the present invention is 6’SL (in the form of its sodium salt) because it brings about a particularly significant increase in SPF.

[0027] In all embodiments of the present invention, preferably, the total amount of the UVA filter selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate is selected in the range of 0.5 to 10% by weight, preferably in the range of 1 to 7.5% by weight, most preferably in the range of 2 to 6% by weight, based on the total weight of the composition.

[0028] Advantageously, in all embodiments of the present invention, the amount of butyl methoxydibenzoylmethane in the composition according to the present invention is advantageously selected in the range of 0.4 to 10% by weight, preferably 0.4 to 9% by weight, 0.4 to 8% by weight, 0.4 to 7% by weight, 0.4 to 6% by weight, 0.4 to 5% by weight, 0.4 to 4% by weight, 0.4 to 3% by weight, 0.5 to 3% by weight, 0.8 to 9% by weight, 0.8 to 8% by weight, 0.8 to 7% by weight, 0.8 to 6% by weight, 0.8 to 5% by weight, 0.8 to 4% by weight, 0.8 to 3% by weight, for example, in the range of 1 to 5% by weight, 2 to 5% by weight, 3 to 5% by weight, or 3.5 to 5% by weight, based on the total weight of the composition.

[0029] More advantageously, in all embodiments of the present invention, the amount of diethylaminohydroxybenzoyl hexyl benzoate in the composition according to the present invention is advantageously selected from the range of 0.5 to 10% by weight, preferably 0.5 to 9% by weight, 0.5 to 8% by weight, 0.5 to 7% by weight, 0.5 to 6% by weight, 0.5 to 5% by weight, 0.5 to 4% by weight, 0.5 to 3% by weight, 1 to 10% by weight, 1 to 9% by weight, 1 to 8% by weight, 1 to 7% by weight, 1 to 6% by weight, 1 to 5% by weight, 2 to 5% by weight, 3 to 5% by weight, for example, 2.5 to 6% by weight, 3 to 6% by weight, 4 to 6% by weight, or 3.5 to 5.5% by weight.

[0030] Preferably, in all embodiments of the present invention, the composition according to the present invention further comprises at least one, preferably at least two, most preferably at least three organic UVB and / or broadband sunscreen activators.

[0031] More preferably, in all embodiments of the present invention, one or more, preferably two or more, most preferably three or more different combinations of organic UVB and / or broadband filters are used in combination with butylmethoxydibenzoylmethane and / or diethylaminohydroxybenzoylhexylbenzoate, for example, combinations of 1-10, 1-7 or 1-5, 1-4, 1-3, 2-10, 2-7 or 2-5 different UVB and / or broadband filters.

[0032] Advantageously, one or more, preferably two or more, more preferably three or more, and even more preferably four or more different UVB and / or broadband filters are selected from the group of organic UVB and / or broadband UV filters having all the preferences and definitions given herein.

[0033] Preferred organic UVB filters absorb radiation in the 280–320 nm region of the ultraviolet spectrum. Examples of preferred UVB absorbers include cinnamate, diphenyl acrylate, benzalmalonate, triazine, and salicylate.

[0034] A preferred organic broadband UV filter provides substantial broad-spectrum protection from both UVA and UVB rays. Examples of preferred broadband absorbers include micronized organic UV filters such as methylenebis-benzotriazolyltetramethylbutylphenol.

[0035] The organic UVB and / or broadband filter may be soluble in water, soluble in non-aqueous materials such as oil, and / or insoluble.

[0036] Preferably, in all embodiments of the present invention, the total amount of all sunscreen activators (including butyl methoxydibenzoylmethane and / or diethylamino hydroxybenzoyl hexyl benzoate) in the composition according to the present invention is selected from about 1 to about 50% by weight of the total weight of the composition, preferably about 3 to about 40% by weight of the total weight of the composition, more preferably about 5 to about 30% by weight, about 10 to about 25% by weight, and about 15 to about 25% by weight (including all and partial ranges between these) of the total weight of the composition.

[0037] In another advantageous embodiment, the total amount of all sunscreen activators is selected from about 5% to about 30% by weight, about 7.5% to about 25% by weight, or about 10% to about 50% by weight (including all and partial ranges between these) relative to the total weight of the composition.

[0038] Furthermore, in all embodiments of the present invention, the total amount of UV filters present in the composition according to the present invention is preferably selected such that the SPF of the final composition (in vitro SPF measured as outlined in ISO 24443 Determination of sunscreen UVA photoprotection in vitro, 01.06.2012, as illustrated in the examples) is at least 10, preferably at least 15, and more preferably at least 20.

[0039] Organic UV filters particularly useful for use in combination with butyl methoxydibenzoylmethane and / or diethylamino hydroxybenzoyl hexyl benzoate as specified herein include anthranilates, cinnamic acid derivatives, salicylic acid derivatives, camphor derivatives, triazine derivatives, e.g., U.S. Patent No. 4,367,390, European Patent No. 863145, European Patent No. 517104, European Patent No. 570838, European Patent No. 796851, European Patent Disclosed in European Patent No. 775698, European Patent No. 878469, European Patent No. 933376, European Patent No. 507691, European Patent No. 507692, European Patent No. 790243 and European Patent No. 944624; benzophenone derivatives; β,β-diphenyl acrylate derivatives; benzotriazole derivatives; benzalmalonate derivatives; benzimidazole derivatives; imidazoline; European Patent No. 669323 and U.S. Patent No. 2,46 Bis-benzoazolyl derivatives disclosed in Patent No. 3,264; p-aminobenzoic acid (PABA) derivatives; methylenebis(hydroxyphenylbenzotriazole) derivatives disclosed in U.S. Patent Nos. 5,237,071 and 5,166,355, UK Patent No. 2303549, German Patent No. 19726184 and European Patent No. 893119; screening polymers and screening silicones, for example, particularly in International Publication No. 93 / 04665. Examples include those disclosed in Lett; dimers derived from α-alkylstyrene, for example, those disclosed in German Patent No. 19855649; 4,4-diarylbutadiene disclosed in European Patent No. 0967200, German Patent No. 19746654, German Patent No. 19755649, European Patent Publication No. A-1008586, European Patent No. 1133980 and European Patent No. 133981; and mixtures thereof.

[0040] For example, additional sunscreen activators used after butyl methoxydibenzoylmethane and / or diethylaminohydroxybenzoyl hexyl benzoate include UV filters that are generally active in the UVB or broadband region, as shown below by their INCI names: p-aminobenzoic acid (PABA) derivatives, particularly PABA, ethyl PABA, ethyl dihydroxypropyl PABA, ethylhexyldimethyl PABA, glyceryl PABA, or PEG-25. PABA, salicylic acid derivatives, especially homosalate (HMS), ethylhexyl salicylate (EHS), dipropylene glycol salicylate, or TEA salicylate; isopropyl dibenzoylmethane; cinnamic acid derivatives, especially ethylhexyl methoxycinnamate (OMS), isopropyl methoxycinnamate, isoamyl methoxycinnamate, cinoxate, DEA methoxycinnamate, diisopropyl methylcinnamate, or ethylhexanoactoglyceryl dimethoxycinnamate; β,β-diphenyl acrylate derivatives, especially octocrylene (OC) or etocrylene; benzophenone, especially benzophenone-1, benzophenone-2, benzophenone-3, or oxybenzone, benzophenone-4, benzophenone-5, benzphenone-1 Zophenone-6, benzophenone-8, benzophenone-9, benzophenone-12, benzylidene camphor derivatives, especially 3-benzylidene camphor, 4-methylbenzylidene camphor, benzylidene camphor sulfonic acid, camphor benzalkonium methosulfate, terephthalylidene dicamphor sulfonic acid, or polyacrylamide methylbenzylidene, benzimidazole derivatives, especially phenylbenzymidazole sulfonic acid (HS), or phenyldibenzymidazole tetrasulfonate disodium, triazine derivatives, especially bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT), ethylhexyl triazone (EHT), diethylhexylbutamide triazone (DBT), or 2,4,Insoluble organic sunscreen activators such as 6-tris(diisobutyl4'-aminobenzalmalonate)-s-triazine, benzotriazole derivatives, especially drometrizole trisiloxane, or methylenebisbenzotriazolyltetramethylbutylphenol (MBBT), trisbiphenyltriazine (A2B) (generally in the form of an aqueous dispersion of active UV filters, e.g., DSM Nutritional Examples include products sold under the trade names PARSOL® MAX (MBBT) by Products or Tinosorb® A2B (A2B) by BASF, anthranilic acid derivatives, particularly menthyl anthranilic acid, imidazoline derivatives, particularly ethylhexyl dimethoxybenzylidene dioxoimidazoline propionate, benzalmalonate derivatives, particularly polyorganosiloxanes containing benzalmalonate functional groups (e.g., commercially available under the INCI name: Polysilicone-15), 4,4-diarylbutadiene derivatives, particularly 1,1'-dicarboxy(2,2'-dimethylpropyl)-4,4-diphenylbutadiene, and mixtures thereof.

[0041] Particularly preferred organic UVB and / or broadband filters used in combination with butyl methoxydibenzoylmethane and / or diethylamino hydroxybenzoyl hexyl benzoate according to the present invention include homosalate (e.g., sold under the trade name "PARSOL® HMS"), ethylhexyl salicylate (e.g., sold under the trade name "PARSOL® EHS"), polysilicone-15 (especially sold under the trade name "PARSOL® SLX"), ethylhexyl methoxycinnamate (e.g., sold under the trade name "PARSOL® MCX"), octocrylene (e.g., Examples include: phenylbenzimidazole sulfonic acid (e.g., sold under the trade name "PARSOL® 340"), phenylbenzimidazole sulfonic acid (e.g., sold under the trade name "PARSOL® HS") or salts thereof, formed during the preparation of compositions using neutralizing agents such as sodium hydroxide triethanolamine, bis-ethylhexyloxyphenol methoxyphenyl triazine (e.g., sold under the trade name "PARSOL® SHIELD"), ethylhexyl triazone (e.g., sold under the trade name "PARSOL® EHT"), diethylhexylbutamide triazone (e.g., commercially available under the trade name Uvasaorb HEB), methylenebisbenzotriazolyltetramethylbutylphenol (e.g., sold under the trade name "PARSOL® MAX"), trisbiphenyl triazine (e.g., sold under the trade name Uvinul A2B), and mixtures thereof.

[0042] The most preferred additional organic UVB and / or broadband filters used in combination with butyl methoxydibenzoylmethane and / or diethylamino hydroxybenzoyl hexyl benzoate according to the present invention are selected from the group consisting of homosalate, ethylhexyl salicylate, polysilicone-15, ethylhexyl methoxycinnamate, octocrylene, phenylbenzimidazole sulfonic acid or its salts, bisethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, diethylhexyl butamide triazone, methylene bisbenzotriazolyltetramethylbutylphenol, trisbiphenyl triazine, butyl methoxydibenzoylmethane, diethylamino hydroxybenzoylhexyl benzoate, preferably ethylhexyl triazone, octocrylene, homosalate, ethylhexyl methoxycinnamate and polysilicone-15, and mixtures thereof.

[0043] In all embodiments of the present invention, the (total) amount of organic UVB and / or broadband filter in the composition according to the present invention is selected from the range of 0.5 to 30% by weight, more preferably 1 to 25% by weight, most preferably 1 to 25% by weight, for example, 1 to 15% by weight, based on the total weight of the composition. Further preferred amounts are selected from the range of 5 to 30% by weight, 7.5 to 30% by weight, 10 to 30% by weight, 5 to 25% by weight, 7.5 to 25% by weight, or 10 to 25% by weight, based on the total weight of the composition.

[0044] In all embodiments of the present invention, the amount of ethylhexyl salicylate in the composition according to the present invention is advantageously selected from the range of 0.5 to 10% by weight, preferably 0.5 to 9% by weight, 0.5 to 8% by weight, 0.5 to 7% by weight, 0.5 to 6% by weight, 0.5 to 5% by weight, for example, 1 to 10% by weight, 2 to 10% by weight, 3 to 10% by weight, or 2 to 7.5% by weight, based on the total weight of the composition.

[0045] In all embodiments of the present invention, the amount of polysilicone-15 in the composition according to the present invention is advantageously selected from the range of 0.4 to 10% by weight, preferably 0.4 to 9% by weight, 0.4 to 8% by weight, 0.4 to 7% by weight, 0.4 to 6% by weight, 0.4 to 5% by weight, 0.4 to 4% by weight, 0.4 to 3% by weight, 0.5 to 3% by weight, 0.8 to 9% by weight, 0.8 to 8% by weight, 0.8 to 7% by weight, 0.8 to 6% by weight, 0.8 to 5% by weight, 0.8 to 4% by weight, or 0.8 to 3% by weight, for example, 1 to 5% by weight, 1 to 3% by weight, 1 to 2.5% by weight, or 1.5 to 2.5% by weight.

[0046] In all embodiments of the present invention, the amount of ethylhexyl methoxycinnamate in the composition according to the present invention is advantageously selected from the range of 0.5 to 10% by weight, preferably 0.5 to 9% by weight, 0.5 to 8% by weight, 0.5 to 7% by weight, 0.5 to 6% by weight, 0.5 to 5% by weight, for example, 1 to 10% by weight, 2 to 10% by weight, 3 to 10% by weight, or 2 to 7.5% by weight, based on the total weight of the composition.

[0047] In all embodiments of the present invention, the amount of octocrylene in the composition according to the present invention is advantageously selected from a range of 0.5 to 15% by weight, preferably 0.5 to 10% by weight, 0.5 to 8% by weight, 1 to 10% by weight, 2 to 10% by weight, 3 to 10% by weight, for example, 5 to 10% by weight, 6 to 10% by weight, or 7 to 10% by weight, based on the total weight of the composition.

[0048] In all embodiments of the present invention, the amount of phenylbenzimidazole sulfonic acid or a salt thereof in the composition according to the present invention is advantageously selected from the range of 0.5 to 5% by weight, preferably 0.5 to 4% by weight, 0.5 to 3% by weight, 1 to 2.5% by weight, 1 to 3% by weight, or 1 to 4% by weight, based on the total weight of the composition.

[0049] In all embodiments of the present invention, the amount of bisethylhexyloxyphenol methoxyphenyl triazine in the composition according to the present invention is advantageously selected from the range of 0.4 to 10% by weight, preferably 0.4 to 9% by weight, 0.4 to 8% by weight, 0.4 to 7% by weight, 0.4 to 6% by weight, 0.4 to 5% by weight, 0.4 to 4% by weight, 0.4 to 3% by weight, 0.5 to 3% by weight, 0.8 to 9% by weight, 0.8 to 8% by weight, 0.8 to 7% by weight, 0.8 to 6% by weight, 0.8 to 5% by weight, 0.8 to 4% by weight, or 0.8 to 3% by weight, for example, 1 to 5% by weight, 1 to 3% by weight, 1 to 2.5% by weight, or 1.5 to 2.5% by weight.

[0050] In all embodiments of the present invention, the amount of ethylhexyl triazone in the composition according to the present invention is advantageously selected from the range of 0.4 to 10% by weight, preferably 0.4 to 9% by weight, 0.4 to 8% by weight, 0.4 to 7% by weight, 0.4 to 6% by weight, 0.4 to 5% by weight, 0.4 to 4% by weight, 0.4 to 3% by weight, 0.5 to 3% by weight, 0.8 to 9% by weight, 0.8 to 8% by weight, 0.8 to 7% by weight, 0.8 to 6% by weight, 0.8 to 5% by weight, 0.8 to 4% by weight, or 0.8 to 3% by weight, for example, 1 to 5% by weight, 1 to 3% by weight, 1 to 2.5% by weight, or 1.5 to 2.5% by weight.

[0051] In all embodiments of the present invention, the amount of diethylhexylbutamide triazone in the composition according to the present invention is advantageously selected from the range of 0.4 to 10% by weight, preferably 0.4 to 9% by weight, 0.4 to 8% by weight, 0.4 to 7% by weight, 0.4 to 6% by weight, 0.4 to 5% by weight, 0.4 to 4% by weight, 0.4 to 3% by weight, 0.5 to 3% by weight, 0.8 to 9% by weight, 0.8 to 8% by weight, 0.8 to 7% by weight, 0.8 to 6% by weight, 0.8 to 5% by weight, 0.8 to 4% by weight, 0.8 to 3% by weight, for example, 1 to 5% by weight, 1 to 3% by weight, or 1.5 to 3% by weight.

[0052] In all embodiments of the present invention, the amount of methylenebisbenzotriazolyltetramethylbutylphenol in the composition according to the present invention (for example, based on a dispersion of MBBT of approximately 45-55% by weight, commercially available under the trade name PARSOL MAX) is advantageously selected in the range of 0.5-10% by weight, preferably 1-10% by weight, more preferably 2-10% by weight, and most preferably 2-6% or 3-6% by weight, based on the total weight of the composition.

[0053] Particularly preferred combinations of organic UV filters in all embodiments of the present invention include, as illustrated, DHHB, OMC, polysilicone-15, and DBT, as well as BMDBM, EHT, OC, and HMS, or DHHB, EHT, BEMPT, OMC, polysilicone-15, DBT, and MBBT.

[0054] In a preferred embodiment, the composition according to the present invention comprises only an organic UV filter.

[0055] Further UVB and / or broadband filters that may be present in the composition of the present invention are inorganic sunscreen activators (inorganic UV filters), such as physical blocking agents such as titanium dioxide or zinc oxide.

[0056] Suitable titanium dioxide UV filters for use according to the present invention (including any pre-dispersions thereof) are available, for example, from DSM Nutritional Products Ltd. as PARSOL® TX (INCI: titanium dioxide, silica, dimethicone), from Tayca as Micro titanium dioxide MT-01, or from Ishihara Sangyo Co., Ltd. as TTO-55I. Double-coated titanium dioxide having an inner alumina coating and an outer simethicone coating (for example, commercially available from EMD Chemicals Inc / Rona as Eusolex T-2000) is also suitable.

[0057] Suitable zinc oxide UV filters for use according to the present invention (including any predispersions thereof) are available, for example, from BASF as Z-Cote or Z-Cote HP1 (2% dimethicone coating), from Tayca as MZ-505S (5% methicone coating), or from DSM Nutritional Products Ltd as PARSOL® ZX (2-3.5% triethoxycaprylylsilane coating).

[0058] Unless otherwise specified in this specification, all given parts and percentages are by weight, based on the total weight of the composition.

[0059] Preferably, the total amount of sialylated human milk oligosaccharide and sunscreen activator in the composition and method of the present invention is present in a weight ratio of 1:50 to 1:1, preferably 1:40 to 1:7.5, preferably 1:30 to 1:5, for example, 1:25 to 1:15. Preferably, there is more sunscreen activator than HMO on a weight basis.

[0060] Since the compositions according to the present invention are intended for topical application, it is well understood that they include physiologically acceptable media, i.e., media compatible with skin, mucous membranes, and keratinous materials such as keratin fibers. In particular, physiologically acceptable media are cosmetically acceptable carriers.

[0061] As used herein, the term “cosmetically acceptable carrier” refers to all carriers and / or excipients and / or diluents conventionally used in topical cosmetic compositions, particularly skincare formulations.

[0062] The exact amount of the support will depend on the actual amounts of the UV filter and all other optional components (e.g., other active ingredients) that a person skilled in the art would classify as different from the support.

[0063] In a favorable embodiment, the composition according to the present invention comprises, based on the total weight of the composition, 50% to 99%, preferably 60% to 98%, more preferably 70% to 98%, for example, particularly 80% to 95% of the carrier.

[0064] In particularly advantageous embodiments, the carrier in all embodiments of the present invention is further composed of at least 30% by weight, more preferably at least 40% by weight, and most preferably at least 45% by weight of water, for example, particularly 50-90% by weight, 50-80% by weight, 50-79% by weight, or 50-60% by weight of water.

[0065] In particular, the compositions according to the present invention are cosmetic or pharmaceutical compositions, preferably cosmetic (non-therapeutic) compositions.

[0066] In one embodiment, the composition according to the present invention is applied to the keratinized tissue of mammals, for example, particularly human skin or human scalp and hair.

[0067] The term "cosmetic composition" as used in this application refers to cosmetic compositions as defined in the title "Kosmetika" of Roempp Lexikon Chemie, 10th edition 1997, Georg Thieme Verlag Stuttgart, New York, and cosmetic compositions as disclosed in A. Domsch, "Cosmetic Compositions", Verlag fuer chemische Industrie (ed. H. Ziolkowsky), 4th edition, 1992.

[0068] Preferred compositions according to the present invention include skincare formulations, decorative formulations, and functional formulations.

[0069] Examples of skincare formulations include, in particular, photoprotective formulations, anti-aging formulations, formulations for the treatment of photoaging, body oils, body lotions, body gels, treatment creams, skin protective ointments, skin powders, moisturizing gels, moisturizing sprays, moisturizers for the face and / or body, skin tanning formulations (i.e., compositions for artificial / sunless tanning and / or browning of human skin), such as self-tanning creams and skin whitening formulations.

[0070] Examples of decorative formulations include, in particular, lipsticks, eyeshadows, mascaras, dry and moist makeup formulations, blushes and / or powders.

[0071] Examples of functional formulations include, but are not limited to, cosmetics or pharmaceutical compositions containing active ingredients such as hormone preparations, vitamin preparations, plant extract preparations, anti-aging preparations, and / or antimicrobial (antibacterial or antifungal) preparations.

[0072] In certain embodiments, the compositions according to the present invention are photoprotective formulations (sun care products, sunscreens) such as sunscreen lotions, sunscreen creams, sunscreen oils, sunscreen blockers, or day care creams having an SPF. Sunscreen creams, sunscreen lotions, and sunscreen lotions are of particular interest.

[0073] The compositions of the present invention (including carriers) may contain conventional auxiliaries and additives such as preservatives / antioxidants, fatty substances / oils, organic solvents, silicones, thickeners, softeners, emulsifiers, defoamers, aesthetic components such as fragrances, surfactants, fillers, anionic, cationic, nonionic or amphoteric polymers or mixtures thereof, propellants, acidifying or basicizing agents, dyes, colorants / colorants, abrasives, absorbents, chelating agents and / or metal ion sequestering agents, essential oils, skin coolants, astringents, pigments, or any other components commonly incorporated into such compositions.

[0074] According to the present invention, the composition according to the present invention may contain further components such as skin whitening; sun protection; treatment of hyperpigmentation; components for preventing or reducing acne, wrinkles, fine lines, atrophy and / or inflammation; chelating agents and / or metal ion sequestering agents; anti-lipidation and slimming agents (e.g., phytanic acid); firming agents; moisturizing and activating agents; self-tanning agents; analgesics; and agents for improving elasticity and skin barrier properties; and carriers and / or excipients or diluents that have been conventionally used in compositions.

[0075] Unless otherwise specified, the excipients, additives, diluents, etc. described below are suitable for the compositions according to the present invention. The required amounts of cosmetics, dermatological adjuvants, and additives can be easily determined by those skilled in the art based on the desired product.

[0076] Additional components may be added to the oil phase, the aqueous phase, or individually, as deemed appropriate. The method of addition can be readily adapted by those skilled in the art.

[0077] Examples of cosmetic excipients, diluents, auxiliaries, additives, and active ingredients commonly used in the skincare industry and suitable for use in the cosmetic compositions of the present invention are, for example, but are not limited to, those listed in the International Cosmetic Ingredient Dictionary & Handbook by the Personal Care Product Council.

[0078] The cosmetic active ingredients useful in this specification may, in some cases, provide two or more benefits or function through two or more mechanisms of action.

[0079] Naturally, those skilled in the art will select the above-mentioned optional additional components, auxiliaries, diluents, and additives, and / or their amounts, with care, such that the favorable properties inherently associated with the combination according to the present invention are not adversely affected or substantially affected by the intended additions.

[0080] In all embodiments of the present invention, preferred compositions are emulsions containing an oil phase and an aqueous phase, such as particularly O / W, W / O, Si / W, W / Si, O / W / O, W / O / W multiple, or Pickering emulsions. The amount of oily phase (i.e., the phase containing all oils and fats) present in such an emulsion is preferably at least 10% by weight, for example, in the range of 10 to 60% by weight, preferably 15 to 50% by weight, and most preferably 15 to 45% by weight, based on the total weight of the composition.

[0081] In a more preferred embodiment, the composition according to the present invention, as outlined herein, is an O / W emulsion comprising an oil phase dispersed in an aqueous phase in the presence of an O / W emulsifier. The preparation of such an O / W emulsion is well known to those skilled in the art and is illustrated in the examples.

[0082] In one advantageous embodiment, the O / W emulsifier is a phosphate ester emulsifier. Preferred phosphate ester emulsifiers include C8-10 alkylethyl phosphate, C9-15 alkyl phosphate, C20-22 alkyl phosphate, ceteareth-2 phosphate, ceteareth-5 phosphate, ceteth-8 phosphate, ceteth-10 phosphate, cetyl phosphate, C6-10 pareth-4 phosphate, C12-15 pareth-2 phosphate, C12-15 pareth-3 phosphate, ceteareth-2 phosphate DEA, cetyl phosphate DEA, oleth-3 phosphate DEA, potassium cetyl phosphate, deceth-4 phosphate, deceth-6 phosphate, and trilaureth-4 phosphate. In all embodiments of the present invention, particularly preferred phosphate ester emulsifiers are C8-C25 alkyl phosphates, particularly C20-22 alkyl phosphates and cetyl phosphates, and especially their respective potassium salts. Specific preferred phosphate ester emulsifiers according to the present invention include, for example, potassium cetyl phosphate, which is commercially available as Amphisol® K by DSM Nutritional Products Ltd Kaiseraugst, or C20-22 alkyl phosphates, which are commercially available as Sensanov WR, for example.

[0083] Further preferred O / W emulsifiers according to the present invention include PEG-30 dipolyhydroxystearate, PEG-4 dilaurate, PEG-8 dioleate, PEG-40 sorbitol oleate, PEG-7 glyceryl cocoate, PEG-20 glyceryl almond oil, PEG-25 hydrogenated castor oil, glyceryl stearate (and) PEG-100 stearate, PEG-7 oleate, PEG-8 oleate, PEG-8 laurate, PEG-60 glyceryl almond oil, PEG-20 methyl glucose sesquistearate, PEG-40 stearate, and stearin It contains PEG-100 acid, PEG-80 sorbitan laurate, steareth-2, steareth-12, oleth-2, ceteth-2, laureth-4, oleth-10, oleth-10 / polyoxyl-10 oleyl ether, ceteth-10, isosteareth-20, ceteareth-20, oleth-20, steareth-20, steareth-21, ceteth-20, isoceteth-20, laureth-23, steareth-100, glyceryl stearate citrate, glyceryl stearate (self-emulsifying type), stearic acid, salts of stearic acid, and polyglyceryl-3 methylglucose distearate. Further preferred emulsifiers include sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, lauryl glucoside, decyl glucoside, sodium stearoyl glutamate, sucrose polystearate, and hydrated polyisobutene. In addition, one or more synthetic polymers can be used as emulsifiers. For example, PVP eicosene copolymer, acrylate / C10-30 alkyl acrylate crosspolymer, acrylate / steareth-20 methacrylate copolymer, PEG-22 / dodecyl glycol copolymer, PEG-45 / dodecyl glycol copolymer, and mixtures thereof.

[0084] Another particularly suitable type of O / W emulsifier is a nonionic self-emulsifying system derived from olive oil, known, for example, as cetearyl olive oil fatty acid (INCI name) and sorbitan olive oil fatty acid (chemical composition: sorbitan ester and cetearyl ester of olive oil fatty acid), sold under the trade name OLIVEM 1000.

[0085] More preferably, commercially available polymer emulsifiers, such as hydrophobized polyacrylic acids like (acrylates / alkyl acrylate (C10-30)) crosspolymers sold by Lubrizol under the trade names Pemulen(registered trademark) TR-1 and TR-2, are preferred.

[0086] Another type of emulsifier that is particularly suitable is a polyglycerol ester or diester of fatty acids (i.e., a polymer in which fatty acids are bonded by esterification with polyglycerin), also called polyglyceryl esters / diesters, such as Isolan GPS [INCI name (diisostearate / polyhydroxystearate / sebacic acid) polyglyceryl-4 (i.e., a diester of a mixture of isostearate, polyhydroxystearate and sebacic acid with polyglycerin-4)], commercially available from Evonik, or Dehymuls PGPH [INCI polyglyceryl-2 dipolyhydroxystearate], commercially available from BASF.

[0087] Polyalkylene glycol ethers, such as Brij 72 (polyoxyethylene(2) stearyl ether) or Brij 721 (polyoxyethylene(21) stearyl ether), available from Croda, are also preferred.

[0088] Particularly advantageous O / W emulsifiers according to the present invention include polyglyceryl-3 methyl glucose distearate, lauryl glucoside (and) polyglyceryl-2 dipolyhydroxystearate, glyceryl citrate stearate, sodium cetearyl sulfate, cetearyl glucoside; polyglyceryl-6 stearate (and) polyglyceryl-6 behenate, cetearyl olivate (and) sorbitan olivate, arachidyl alcohol (and) behenyl One or more of the following: alcohols (and) arachidyl glucosides, cetearyl alcohol (and) coconut oil alkyl glucosides, coconut oil alkyl glucosides (and) coconut alcohols, PEG-100 stearate (and) glyceryl stearate, sodium stearoyl glutamate, steareth-20, steareth-21, steareth-25, steareth-2, ceteareth-25, and ceteareth-6 (all listed by their INCI names).

[0089] In one embodiment, according to the present invention, it is particularly preferable that the composition contains a C8-C25 alkyl phosphate, preferably a C20-22 alkyl phosphate and / or cetyl phosphate, as an emulsifier or at least a co-emulsifier.

[0090] In another embodiment, according to the present invention, it is particularly preferable that the composition contains polyglyceryl-6 stearate and / or polyglyceryl-6 behenate as an emulsifier, preferably in the presence of cetyl phosphate, more preferably potassium cetyl phosphate, as a co-emulsifier.

[0091] In further embodiments, according to the present invention, it is particularly preferable that the composition contains polyglyceryl-3 methyl glucose distearate as an emulsifier.

[0092] Each of these at least one O / W, Si / W emulsifier is preferably used in an amount ranging from 0.5 to 10% by weight, particularly 0.5 to 5% by weight, for example most specifically 0.5 to 4% by weight or 0.5 to 3% by weight, based on the total weight of the composition.

[0093] When a phosphate ester emulsifier having all the definitions and preferences given herein is used as a co-emulsifier, the amount thereof is preferably selected based on the total weight of the composition in the range of 0.1 to 1% by weight, for example particularly in the range of 0.25 to 0.75% by weight, most specifically in the range of 0.3 to 0.7% by weight or 0.4 to 0.6% by weight.

[0094] Suitable W / O or W / Si emulsifiers according to the present invention include polyglyceryl-2-dipolyhydroxystearic acid, PEG-30 dipolyhydroxystearic acid, cetyl dimethicone copolyol, polyglyceryl-3 diisostearate polyglycerol ester of oleic acid / isostearate, polyglyceryl-6 hexalicinoleate, polyglyceryl-4 oleate, PEG-8 propylene glycol oleic acid / coconut oil fatty acid, magnesium stearate, sodium stearate, potassium laurate, potassium ricinoleate, sodium coconut fatty acid, sodium talusate, potassium castrate, sodium oleate, and mixtures thereof. Further preferred W / Si emulsifiers are lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone and / or PEG-9 polydimethylsiloxyethyl dimethicone and / or cetyl PEG / PPG-10 / 1 dimethicone and / or PEG-12 dimethicone crosspolymer and / or PEG / PPG-18 / 18 dimethicone. At least one W / O emulsifier is used in an amount of preferably about 0.001 to 10% by weight, more preferably 0.2 to 7% by weight, based on the total weight of the composition.

[0095] The compositions according to the present invention more advantageously contain at least one surfactant, such as selected from the group of monoglycerides and diglycerides and / or fatty alcohols. The surfactant is generally used in an amount selected from the range of 0.1 to 10% by weight, particularly 0.5 to 7% by weight, and most specifically 1 to 5% by weight, based on the total weight of the composition. Particularly preferred surfactants are selected from the list of alkyl alcohols such as cetyl alcohol (Lorol C16, Lanette 16), cetearyl alcohol (Lanette O), stearyl alcohol (Lanette 18), behenyl alcohol (Lanette 22), polyhydroxystearic acid, glyceryl stearate, glyceryl myristate (Estol 3650), hydrogenated cocoglycerides (Lipocire Na10), and mixtures thereof.

[0096] In all embodiments of the present invention, it is particularly advantageous when the composition also contains cetyl alcohol and / or glyceryl stearate.

[0097] As an advantageous embodiment of the composition of the present invention, the composition comprises di(caprylic / capric acid)butylene glycol, phenethyl benzoate, and alkyl benzoate (C 12 ~C 15 ), dibutyl adipate, diisopropyl sebacate, dicaprylyl carbonate, dialkyl (C) tartrate 12~13 ), butyloctyl salicylate, diethylhexyl syringylidene malonate, hydrogenated castor oil dimer acid, triheptanoin, alkyl lactate (C 12~13 ), alkyl benzoate (C 16~17 ), also includes one or more oils selected from propylheptyl caprylate, caprylic / capric triglyceride, 2,6-naphthalenedicarboxylate diethylhexyl, octyldodecanol, coconut oil fatty acid ethylhexyl, and phenethyl alcohol. Preferably, the composition according to the present invention includes, as oils, caprylic / capric triglyceride, dibutyl adipate, phenylethyl benzoate, butylene glycol, phenethyl benzoate, phenethyl alcohol, and C benzoate.12 ~C 15 It contains alkyl groups, diisopropyl sebacate, and mixtures thereof.

[0098] In a more advantageous embodiment of the present invention, the composition of the present invention preferably further comprises a preservative and / or preservative booster, selected from the group consisting of ethanol, phenoxyethanol, sodium benzoate, potassium sorbate, phenethyl alcohol, hydroxyactofenone, ethylhexylglycerin, hexylglycerin, glyceryl caprylate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol (caprylyl glycol), 1,2-decanediol and 2-methyl-1,3-propanediol and mixtures thereof, and most preferably selected from the group consisting of phenoxyethanol and ethylhexylglycerin and mixtures thereof. Where present, the preservative and / or preservative booster are used in an amount of preferably 0.01 to 5% by weight, more preferably 0.05 to 4% by weight, and most preferably 0.1 to 3.0% by weight, based on the total weight of the composition.

[0099] The present invention is advantageous when the formulation contains one or more alkanediols from the group consisting of 1,3-propanediol, 1,2-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, and 2-methyl-1,3-propanediol. When one or more alkanediols are present, they are used in an amount of preferably 0.1 to 7% by weight, more preferably 0.5 to 7% by weight, and most preferably 1.0 to 5.0% by weight, based on the total weight of the composition.

[0100] According to the present invention, it is even more advantageous when the emulsion composition of the present invention contains phenoxyethanol, ethylhexylglycerin, glyceryl caprylate and / or phenethyl alcohol, preferably phenoxyethanol and / or ethylhexylglycerin and / or glyceryl caprylate and / or phenethyl alcohol, most preferably phenoxyethanol and ethylhexylglycerin and / or glyceryl caprylate.

[0101] In another advantageous embodiment, the compositions according to the present invention do not contain any parabens, benzethonium chloride, piroctone olamine, lauroyl alginate, methylisothiazolinone, chloromethylisothiazolinone, bronopol, benzalkonium chloride, formaldehyde-releasing compounds, salicylic acid, triclosan, DMDM ​​hydantoin, chlorphenesin, or IPBC (iodopropynyl butylcarbamate).

[0102] The composition according to the present invention may further contain one or more emollients that soothe and soften the skin. Examples of emollients include silicones (dimethicone, cyclomethicone), vegetable oils (grape seed oil, sesame seed oil, jojoba oil, etc.), butters (cocoa butter, shea butter), and petrolatum derivatives (petrolatum, mineral oil).

[0103] In another embodiment, the composition of the present invention includes limonene, citral, linalool, alpha-isomethyl ionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1,1,3,4,4,6-hexamethyltetraline, adipic acid diester, cinnamal, amyl salicylate, alpha-amyl cinnamaldehyde, alpha-methyl ionone, butylphenyl methylpropional, cinnamal, amyl cinnamyl alcohol, anise alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, salicylic acid It may contain one or more fragrances selected from benzyl tate, bergamot oil, bitter orange oil, butylphenyl methylpropional, cardamom oil, cedrol, cinnamal, cinnamyl alcohol, citronellyl methylcrotate, citrus oil, coumarin, diethyl succinate, ethyl linalool, eugenol, Ebernia furfrasea extract, hornwort extract, farnesol, guaiawood oil, hexyl cinnamal, hexyl salicylate, hydroxycitronellal, lavender oil, lemon oil, linalyl acetate, mandarin oil, menthyl PCA, methylhexadecane, nutmeg oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate, and vanillin.

[0104] The compositions of the present invention may, advantageously, include humectants. Humectants are compounds or mixtures of compounds that, after the cosmetic composition is applied to or spread on the skin surface, impart to the cosmetic composition a quality that reduces water loss from the stratum corneum (also known as transepidermal water loss (TEWL)) and / or has a favorable effect on the hydration of the stratum corneum.

[0105] Non-limiting examples of humectants advantageous for use in the present invention include glycerol, lactic acid and / or lactates, particularly sodium lactate, butylene glycol, propylene glycol, 1,3-propanediol, biosaccharide gum-1, wild soybean, ethylhexyloxyglycerol, pyrrolidone carboxylic acid, and urea. Particularly advantageous is the use of high molecular weight humectants from the group of polysaccharides that are water-soluble and / or water-swellable and / or can be gelled by the power of water. Particularly advantageous are, for example, hyaluronic acid, chitosan, and / or fucose-rich polysaccharides, the fucose-rich polysaccharides which are registered in Chemical Abstracts under registration number 178463-23-5 and are available, for example, from SOLABIA SA under the name Fucogel® 1000. Humidifiers can also be advantageously used, for example, as active anti-wrinkle ingredients to protect against the types of skin changes that occur with skin aging.

[0106] Particularly advantageous humectants used in the compositions according to the present invention are glycerin, sodium hyaluronate, isomerized sugar and / or 1,3-propanediol, in a total amount selected from a range of 0.1 to 5% by weight, more preferably 0.1 to 3% by weight, and even more preferably 0.5 to 3% by weight, based on the total weight of the composition.

[0107] While not essential, advantageously, the cosmetic compositions of the present invention may further include fillers that, for example, further improve the sensory and cosmetic properties of the formulation and have the effect of evoking or emphasizing a skin feel such as velvet or silk. Advantageous fillers in the sense of the present invention include starch and starch derivatives (e.g., tapioca starch, cross-linked starch phosphate, aluminum starch octenyl succinate, sodium starch octenyl succinate, etc.), Valvance pigments that essentially exhibit neither UV filtering nor coloring effects (e.g., Valvance Touch 210 or Valvance Touch 250), and / or Aerosils® (CAS No. 7631-86-9), and / or talc, and / or polyethylene, nylon, and dimethylsilylated silica.

[0108] The aqueous phase of the composition of the present invention may, advantageously, include commonly used cosmetic additives, for example, individually or in combination in each case, alcohols, particularly those with a low number of carbon atoms, preferably ethanol and / or isopropanol or polyols with a low number of carbon atoms, in addition to their ethers, preferably propylene glycol, glycerol, electrolytes, self-tanning agents, and also one or more thickeners, advantageously silicon dioxide, aluminum silicate, polysaccharides and / or derivatives thereof, thickeners that can be selected from the group of hyaluronic acid, xanthan gum, hydroxypropyl methylcellulose, particularly advantageously polyacrylates, preferably thickeners from the group of polyacrylates referred to as Carbopol (examples include 980, 981, 1382, 2984 and 5984 type carbopols). Further advantageous thickeners according to the present invention include those with the INCI name (acrylate / C10-30 alkyl acrylate crosspolymer) (e.g., Pemulen TR 1, Pemulen TR 2, Carbopol 1328 from Lubrizol), as well as Aristoflex AVC (INCI: (ammonium acryloyldimethyltaurate / VP) copolymer) and Simugel NS (INCI: (hydroxyethyl acrylate / sodium acryloyldimethyltaurate) copolymer (and) squalane (and) polysorbate 60).

[0109] According to the present invention, it is even more preferable when the composition according to the present invention contains a thickening agent. Suitable thickening agents used in accordance with the present invention include xanthan gum, crosslinked acrylate / C10-C30 alkyl polymers, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and / or vinylpyrrolidone / hexadecane copolymer, preferably xanthan gum and / or hydroxyethyl acrylate / sodium acryloyldimethyl taurate, most preferably xanthan gum.

[0110] The amount of xanthan gum, if present, is preferably selected in the range of 0.1 to 1% by weight, more preferably in the range of 0.15 to 0.75% by weight, and most preferably in the range of 0.2 to 0.4% by weight, based on the total weight of the composition.

[0111] The oil phase of the composition of the present invention may also advantageously contain commonly used cosmetic auxiliaries, such as dextrin palmitate (Rheopearl KL2, Chiba Flour Milling), dextrin palmitate and C15-19 alkanes (TILAMAR FITS, DSM), polyurethane-79 and caprylic / caprylic triglyceride (Oilkemia 5S, Lubrizol), ethylene / propylene / styrene copolymer and butylene / ethylene / styrene copolymer and pentaerythrityltetra-di-t-butylhydroxyhydrocinnamate and squalane (Veggi Gel, Aiglon), dibutyl lauroyl glutamide and dibutyl ethylhexanoyl glutamide and octyldodecanol (AJK-OD246, Ajinomoto).

[0112] The amount of the thickener (e.g., active thickening polymer), if present, is preferably selected in the range of 0.1 to 15% by weight, more preferably in the range of 0.5 to 10% by weight, and most preferably in the range of 1.0 to 8.0% by weight, based on the total weight of the composition.

[0113] The composition of the present invention requires a surprisingly small total amount of UV filter.

[0114] In another embodiment, the composition may have an SPF of at least 15, preferably at least 20, and most preferably at least 30.

[0115] According to the present invention, it is advantageous when the composition of the present invention includes a film-forming agent. A film-forming agent in the sense of the present invention is a substance having various compositions and is characterized by having the following properties. When the film-forming agent is dissolved in water or another suitable solvent and this solution is then applied to the skin, the film-forming agent forms a film after the solvent evaporates, and this film essentially fixes the UV filter to the skin and enhances the water resistance of the product.

[0116] It is particularly advantageous to select a film-forming agent from the group of polymers based on polyvinylpyrrolidone (PVP).

[0117] For example, vinylpyrrolidone copolymers such as PVP hexadecane copolymer and PVP eicosene copolymer, available from Ashland under trade names Antaron V216 and Antaron V220, are particularly preferred.

[0118] Similarly, further polymeric film-forming agents such as sodium polystyrene sulfonate (available from National Starch and Chemical Corp. under the trade name Flexan 130) and / or polyisobutene (available from Rewo under the trade name Rewopal PIB1000) are also advantageous. Further examples of suitable polymers include polyacrylamide (Sepigel 305), polyvinyl alcohol, PVP, PVP / VA copolymer, polyglycol, and acrylate / octylacrylamide copolymer (Dermacryl 79). It is equally advantageous to use hydrogenated castor oil dimer dilinoleate (CAS 646054-62-8, INCI hydrogenated castor oil dimer dilinoleate) (available from Higher Alcohol Industries, Ltd. under the name Risocast DA-H) or PPG-3 benzyl ether myristate (CAS 403517-45-3) (available from Croda Chemicals under the trade name Crodamol STS).

[0119] The composition according to the invention generally has a pH in the range of 3 to 10, preferably in the range of 4 to 8, and most preferably in the range of 4 to 7.5. This pH can be easily adjusted as needed using a suitable acid, such as citric acid, or a base, such as NaOH, or a suitable amine, such as tromethamine, according to standard methods in the art.

[0120] The amount of the cosmetic composition applied to the skin is not critical and can be easily adjusted by those skilled in the art. Preferably, the amount is 0.1 to 3 mg / cm 2 of the skin area, for example, preferably 0.1 to 2 mg / cm 2 of the skin area, and most preferably 0.5 to 2 mg / cm 2 is selected within the skin area.

[0121] The following examples are provided to further illustrate the composition and effects of the present invention. These examples are merely illustrative and are not intended to limit the scope of the present invention in any way.

[0122] [Examples] [Brief Explanation] The 3SL and 6SL of HMO were evaluated for their SPF boosting effect. For this purpose, various sunscreens were prepared according to standard methods in the art as outlined in Table 1a.

[0123] [In Vitro SPF Measurement] The in vitro SPF test was performed on four PMMA plates (HD6 plates manufactured by Helioscreen, 5 cm × 5 cm, roughness of Sa 6 μm). 32.5 mg of each formulation (i.e., 1.3 mg / cm 2 ) was uniformly applied onto the PMMA plates and dried for 30 minutes.

[0124] In vitro SPF was measured using a Labsphere 2000 UV Transmittance Analyzer. Each PMMA plate was measured nine times at different points on the plate, yielding 36 data points. The results were calculated as the average of these 36 data points.

[0125] [Table 1]

[0126] [Table 2]

[0127] [Table 3]

[0128] [Table 4]

[0129] As shown in Tables 1b and 1c, 3SL and 6SL HMOs boost in vitro SPF by 15% to 25%.

[0130] [Table 5]

[0131] [Table 6]

Claims

1. A composition comprising at least one UVA filter selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate, and at least one sialylated human milk oligosaccharide.

2. The composition according to claim 1, wherein the at least one sialylated human milk oligosaccharide is present in an amount effective for increasing the SPF of the composition.

3. The composition according to claim 1 or 2, wherein the amount of the at least one sialylated human milk oligosaccharide is selected in the range of 0.2 to 5% by weight based on the total weight of the composition.

4. The composition according to claim 1 or 2, wherein at least one sialylated human milk oligosaccharide is selected from the group consisting of 3'-sialyl lactose, 6'-sialyl lactose, and salts thereof.

5. The composition according to claim 1 or 2, wherein the total amount of UVA filters selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate in the composition is selected in the range of 0.5 to 10% by weight based on the total weight of the composition.

6. The composition according to claim 1 or 2, wherein the composition further comprises at least one organic UVB and / or broadband filter.

7. The composition according to claim 6, wherein the at least one additional organic UVB and / or broadband filter is selected from the group consisting of homosalate, ethylhexyl salicylate, polysilicone-15, ethylhexyl methoxycinnamate, octocrylene, phenylbenzimidazole sulfonic acid or a salt thereof, bisethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, diethylhexyl butamide triazone, methylenebisbenzotriazolyltetramethylbutylphenol, and trisbiphenyl triazine, and any mixture thereof.

8. The composition according to claim 1 or 2, wherein the total amount of UV filter in the composition is selected in the range of 1 to 50% by weight based on the total weight of the composition.

9. The composition according to claim 1 or 2, comprising a carrier consisting of at least 30% by weight of water.

10. The composition according to claim 1 or 2, wherein the composition is an emulsion.

11. The composition according to claim 10, wherein the emulsion is an O / W emulsion.

12. The composition according to claim 11, wherein the O / W emulsion comprises an oily phase dispersed in an aqueous phase in the presence of an emulsifier selected from the group consisting of C8-C25 alkyl phosphates, polyglyceryl-6 stearate, polyglyceryl-6 behenate and / or polyglyceryl-3 methylglucose distearate.

13. Use of the composition according to claim 1 or 2 for protecting the skin from the effects of skin aging and as a sunscreen composition.

14. A method for enhancing the sun protection factor (SPF) properties of a composition comprising at least one UVA filter selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate, the method comprising adding at least one sialylated human milk oligosaccharide to the composition in an amount effective for enhancing the SPF properties of the composition.

15. A method for preparing a composition, comprising adding to the composition during the preparation of the composition at least one UVA filter selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate, and at least one sialylated human milk oligosaccharide.

16. Use of sialylated human milk oligosaccharides to enhance the sun protection index (SPF) of a composition comprising at least one UVA filter selected from the group consisting of butyl methoxydibenzoylmethane and diethylamino hydroxybenzoyl hexyl benzoate.