Thiazole derivative inhibitors, their manufacturing methods and applications

Abstract

This invention relates to thiazole derivative inhibitors, methods for producing the same, and applications thereof. In particular, this invention relates to compounds, methods for producing the same, pharmaceutical compositions containing the compounds, and their uses as inhibitors in the treatment of autoimmune diseases.

Description

[Technical Field] 【0001】 This application is, Application number: CN2023105419877, Application date: May 12, 2023 Application number: CN202310619175X, Application date: May 29, 2023 Application number: CN2023107825907, Application date: June 28, 2023 Application number: CN2023108637750, Application date: July 13, 2023 Application number: CN2023109021873, Application date: July 20, 2023 Application number: CN2023110709386, Application date: August 23, 2023 Application number: CN2023113623762, Application date: October 19, 2023 Application number: CN2023114958852, Application date: November 09, 2023 Application number: CN2023116431270, Application date: December 1, 2023 Application number: CN2024101106204, Application date: January 25, 2024 Priority is claimed for application number: CN2024102259090, filing date: February 28, 2024. 【0002】 This invention belongs to the field of drug synthesis and, more specifically, relates to thiazole derivative inhibitors, their manufacturing methods, and applications. [Background technology] 【0003】 Human IL-17 (interleukin 17) is a large class of pro-inflammatory cytokines. Human IL-17 comprises a total of six family members: IL-17A (also known as CTLA-8), IL-17B, IL-17C, IL-17D, IL-17E (also known as IL-25), and IL-17F. The human IL-17 receptor family comprises a total of five family members: IL-17RA, IL-17RB, IL-17RC, IL-17RD, and IL-17RE. Human IL-17 initiates downstream signaling pathways by binding to heterodimeric IL-17 receptors. 【0004】 IL-17A is the most studied cytokine. IL-17A is produced by various cells, including Th17 (helper T cells 17), Tc17 (killer T cells 17), NKT (natural killer T cells), γδT (γδT cells), and epithelial cells. By binding to IL-17 receptors such as those on skin cells, IL-17 activates the Act1 (TRAF3 interacting protein 2)-dependent MAPK and NF-κB signaling pathways, thereby increasing the expression levels of various cytokines (e.g., IL-6, TNF-α, G-CSF, GM-CSF, etc.), chemokines (e.g., CXCL1, CXCL2, CXCL5, CXCL8, CXCL10, etc.), antimicrobial peptides (e.g., Defensin, MUCSAC, S100A7, etc.), and matrix metalloproteinases (e.g., MMP1, etc.) from the transcriptional level. IL-17A is involved in regulating various important biological processes, including bacterial and fungal infections, wound healing, and inflammation promotion. 【0005】 The IL-17A pathway also plays an important role in autoimmune / inflammatory diseases. According to preclinical trials, IL-23 or IL-17RA knockout mice are resistant to imiquimod (IMQ)-induced psoriasis, and IL-17 monoclonal antibodies can effectively inhibit IMQ- or IL-23-induced psoriasis-related scores. IL-17-related therapeutic antibodies (such as Secukinumab, Ixekizumab, Brodalumab, Bimekizumab, etc.) have also been approved as therapeutic drugs for diseases such as psoriasis and ankylosing spondylitis, showing excellent clinical therapeutic effects and mild and controllable toxic side effects. 【0006】 However, IL-17-related therapeutic antibodies are costly, require subcutaneous or intravenous injection, and are less accessible and less convenient for patients with autoimmune / inflammatory diseases who require long-term administration. The development of highly active oral small molecule IL-17 inhibitors can greatly improve the drug accessibility and convenience for patients, and has very high clinical and commercial value. 【Summary of the Invention】 【0007】 The object of the present invention is to provide a compound represented by formula (I-A), its stereoisomers or its pharmaceutically acceptable salts, 【Chemical Formula】 where M1 is selected from N or CR3, L1 is a bond, -O-, -NH-, -CO-, -CONH-, C 1-3 alkylene group, C 2-4 alkenylene group, C 2-4 alkynylene group, -O-C 1-3 alkylene-, -S-C 1-3 alkylene-, -C 1-3 alkylene-NH-, -C 1-3 alkylene-C(O)NH-, -C 1-3 alkylene-NHC(O)-, -C 1-3 alkylene-S(O) r1 -, -C 1-3 alkylene-NHS(O) r2- or -C 1-3 Alkylene-S(O) r3 Selected from NH-, and the aforementioned -NH-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1 -, -C 1-3 Alkilen-NHS(O) r2 - or -C 1-3 Alkylene-S(O) r3 NH- can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups or 5-6 membered heteroaryl groups, preferably bonded. Ring B is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from an aryl group or a 5-14 membered heteroaryl group, or ring B is absent. R is C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from an aryl group or a 5-14 membered heteroaryl group, the C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 The aryl group or 5-14 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-12 Cycloalkyl group, 3- to 12-membered heterocyclyl group, C 6-10 Aryl group, 5- to 10-membered heteroaryl group, -(CH2) n1 OR b1 、-(CH2) n2 C(O)R b2 、-(CH2) n3 NHC(O)R b3 、-(CH2) n4 C(O)NHR b4 、-(CH2) n5 NR b5 R b6 、-(CH2) n6 S(O) n7 R b7 、-(CH2) n8 S(O)2NHR b8 、-(CH2) n9 NHS(O)2R b9 selected from, and the amino group, C 1-6 alkyl group, C 2-6 alkenyl group, C 2-6 alkynyl group, C 1-6 deuterated alkyl group, C 1-6 haloalkyl group, C 1-6 alkoxy group, C 1-6 deuterated alkoxy group, C 1-6 haloalkoxy group, C 1-6 hydroxyalkyl group, C 3-12 cycloalkyl group, 3- to 12-membered heterocyclyl group, C 6-10 aryl group or 5- to 10-membered heteroaryl group may optionally further have hydrogen, deuterium, halogen, amino group, hydroxy group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF2, =CHF, =NOC 1-6 alkyl group, C 1-6 alkyl group, C 2-6 alkenyl group, C 2-6 alkynyl group, C 1-6 deuterated alkyl group, C 1-6 haloalkyl group, C 1-6 alkoxy group, C 1-6Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-10 membered heteroaryl group. 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-10 The aryl group and 5-10 membered heteroaryl group substituents can optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF2, =CHF, =NOC 1-6 Alkyl alkyl group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Heteroalkyl groups, C 1-6 Deuterated heteroalkyl groups, C 1-6 Haloheteroalkyl groups, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, the C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Heteroalkyl groups, C 1-6 Deuterated heteroalkyl groups, C 1-6 Haloheteroalkyl groups, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF2, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Heteroalkyl groups, C 1-6 Deuterated heteroalkyl groups, C 1-6 Haloheteroalkyl groups, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It is substituted with one or more aryl groups and 5-10 membered heteroaryl groups, preferably R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NRb5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-10 membered heteroaryl group. 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group substituents may optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 2-1 and R 2-2 It is connected to C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R and R 2-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R3 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) o1 Ure c1 ,-(CH2) o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHR d10 ) p2 C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 ) p5 NR d5 R d6,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHR d10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) p1 Ure d1 ,-(CH2) p2 C(O)R d2 ,-(CH2) p3 NHC(O)R d3 ,-(CH2) p4 C(O)NHR d4 ,-(CH2) p5 NR d5 R d6 ,-(CH2) p6 S(O) p7 R d7 ,-(CH2) p8 S(O)2NHR d8 ,-(CH2) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R5 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) q1 Ure e1 ,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2) q8 S(O)2NHR e8 ,-(CH2) q9 NHS(O)2R e9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R6 and R7 are, independently, hydrogen and C. 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from an aryl group or a 5-14 membered heteroaryl group, the C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 The aryl group or 5-14 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R a1 , R a2 , R a3 , Ra4 , R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R c7 , R c8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 , R d8 , R d9 and R d10 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. u is 0, 1, 2, 3, 4, or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. r1, r2, and r3 are each independently selected from 0, 1, or 2. 【0008】 In some embodiments of the present invention, C described in each group 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group substituents may optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. 【0009】 In some embodiments of the present invention, R is [ka] That is the case. 【0010】 In some embodiments of the present invention, the compound is as shown in (IA-1), [ka] Here, ring A is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from aryl groups or 5-14 membered heteroaryl groups, R1 can independently be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C1-6 haloalkyl group, C 1-6 alkoxy group, C 1-6 deuterated alkoxy group, C 1-6 haloalkoxy group, C 1-6 hydroxyalkyl group, C 3-8 cycloalkyl group, 3- to 8-membered heterocyclyl group, C 6-10 aryl group, 5- to 10-membered heteroaryl group, -(CH2) m1 OR a1 、-(CH2) m2 C(O)R a2 、-(CH2) m3 NHC(O)R a3 、-(CH2) m4 C(O)NHR a4 、-(CH2) m5 NR a5 R a6 、-(CH2) m6 S(O) m7 R a7 、-(CH2) m8 S(O)2NHR a8 、-(CH2) m9 NHS(O)2R a9 selected from, and the amino group, C 1-6 alkyl group, C 2-6 alkenyl group, C 2-6 alkynyl group, C 1-6 deuterated alkyl group, C 1-6 haloalkyl group, C 1-6 alkoxy group, C 1-6 deuterated alkoxy group, C 1-6 haloalkoxy group, C 1-6 hydroxyalkyl group, C 3-8 cycloalkyl group, 3- to 8-membered heterocyclyl group, C 6-10 aryl group or 5- to 10-membered heteroaryl group may optionally further have hydrogen, deuterium, halogen, amino group, hydroxy group, cyano group, nitro group, oxo group, thio group, C 1-6 alkyl group, C 2-6 alkenyl group, C 2-6 alkynyl group, C 1-6 deuterated alkyl group, C 1-6 haloalkyl group, C 1-6 alkoxy group, C 1-6Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups, where x is 0, 1, 2, 3, 4, or 5. 【0011】 In some embodiments of the present invention, the compound represented by formula (IA) is as shown in formula (I), [ka] Here, ring A is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from aryl groups or 5-14 membered heteroaryl groups, R1 can independently be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7, -(CH2) m8 S(O)2NHR a8 , -(CH2) m9 NHS(O)2R a9 selected from, the amino group, C 1-6 alkyl group, C 2-6 alkenyl group, C 2-6 alkynyl group, C 1-6 deuterated alkyl group, C 1-6 haloalkyl group, C 1-6 alkoxy group, C 1-6 deuterated alkoxy group, C 1-6 haloalkoxy group, C 1-6 hydroxyalkyl group, C 3-8 cycloalkyl group, 3- to 8-membered heterocyclyl group, C 6-10 aryl group or 5- to 10-membered heteroaryl group may optionally be further substituted with one or more of hydrogen, deuterium, halogen, amino group, hydroxy group, cyano group, nitro group, oxo group, thio group, C 1-6 alkyl group, C 2-6 alkenyl group, C 2-6 alkynyl group, C 1-6 deuterated alkyl group, C 1-6 haloalkyl group, C 1-6 alkoxy group, C 1-6 deuterated alkoxy group, C 1-6 haloalkoxy group, C 1-6 hydroxyalkyl group, C 3-8 cycloalkyl group, 3- to 8-membered heterocyclyl group, C 6-10 aryl group and 5- to 10-membered heteroaryl group, and R 2-1 and R 2-2 are each independently hydrogen, deuterium, halogen, amino group, hydroxy group, cyano group, nitro group, oxo group, thio group, C 1-6 alkyl group, C 2-6 alkenyl group, C 2-6 alkynyl group, C 1-6 deuterated alkyl group, C 1-6 haloalkyl group, C 1-6 alkoxy group, C 1-6 deuterated alkoxy group, C 1-6 haloalkoxy group, C 1-6Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 2-1 and R 2-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R3 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) o1 Ure c1 ,-(CH2) o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHR d10 ) p2 C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 ) p5 NR d5 R d6 ,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHRd10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) p1 Ure d1 ,-(CH2) p2 C(O)R d2 ,-(CH2) p3 NHC(O)R d3 ,-(CH2) p4 C(O)NHR d4 ,-(CH2) p5 NR d5 R d6 ,-(CH2) p6 S(O) p7 R d7 ,-(CH2) p8 S(O)2NHR d8 ,-(CH2) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R5 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) q1 Ure e1,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2) q8 S(O)2NHR e8 ,-(CH2) q9 NHS(O)2R e9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R a1 , R a2 , R a3 , Ra4 , R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R c7 , R c8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 , R d8 , R d9 and R d10 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. x is 0, 1, 2, 3, 4, or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. 【0012】 In some embodiments of the present invention, the compound shown in (I) above is as shown in formula (IB). [ka] 【0013】 In some embodiments of the present invention, the compound shown in (I) above is as shown in formula (IB-1) or (IB-2). [ka] 【0014】 In some embodiments of the present invention, the compound shown in (I) above is as shown in formula (I-1) or (I-2), [ka] Here, R 4-1-1 These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 w is selected from an aryl group or a 5- to 10-membered heteroaryl group, and w is selected from 0, 1, 2, 3, 4, 5, or 6. 【0015】 In some embodiments of the present invention, the compound shown in (I-1) above is as shown in formula (I-1-1), (I-1-2), (I-2-1), or (I-2-2). [ka] 【0016】 In some embodiments of the present invention, the compound shown in formula (I-1-1) above is further shown in formula (I-1-1-1). [ka] 【0017】 In some embodiments of the present invention, the compound shown in formula (IA) above is as shown in formula (VII), [ka] Here, M1 is selected from N or CR3. Ring A is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from aryl groups or 5-14 membered heteroaryl groups, R1 can independently be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O)m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-10 membered heteroaryl group. 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group substituents may optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 2-1 and R 2-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R3 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) o1 Ure c1 ,-(CH2) o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHR d10 ) p2 C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 ) p5 NR d5 R d6 ,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHR d10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) p1 Ure d1 ,-(CH2) p2 C(O)R d2 ,-(CH2) p3 NHC(O)R d3 ,-(CH2)p4 C(O)NHR d4 ,-(CH2) p5 NR d5 R d6 ,-(CH2) p6 S(O) p7 R d7 ,-(CH2) p8 S(O)2NHR d8 ,-(CH2) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R5 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) q1 Ure e1 ,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2)q8 S(O)2NHR e8 ,-(CH2) q9 NHS(O)2R e9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R a1 , R a2 , R a3 , R a4 , R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R c1 , R c2, R c3 , R c4 , R c5 , R c6 , R c7 , R c8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 , R d8 , R d9 and R d10 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. x is 0, 1, 2, 3, 4, or 5. u is 0, 1, 2, 3, 4, or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. 【0018】 In some embodiments of the present invention, the compound shown in formula (VII) above is as shown in formula (VII-B). [ka] 【0019】 In some embodiments of the present invention, the compound represented by formula (VII) is as shown in formula (VII-B-1) or (VII-B-2). [ka] 【0020】 In some embodiments of the present invention, the compound shown in formula (VII) above is as shown in formula (VII-1) or (VII-2), [ka] Here, R 4-1-1 These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 w is selected from an aryl group or a 5- to 10-membered heteroaryl group, and w is selected from 0, 1, 2, 3, 4, 5, or 6. 【0021】 In some embodiments of the present invention, the compounds represented by formula (VII-1) or (VII-2) are as shown in formula (VII-1-1), (VII-1-2), (VII-2-1), or (VII-2-2). [ka] 【0022】 In some embodiments of the present invention, ring A is C 3-8Cycloalkyl group, 3-10 membered heterocyclyl group, C 6-10 Selected from an aryl group or a 5-10 membered heteroaryl group, preferably a 5-6 membered heterocyclyl group, a 5-6 membered heteroaryl group, a 5-6 membered heteroaryl group condensed into a 5-6 membered heteroaryl group, a 5-6 membered heteroaryl group condensed into a phenyl group, or a 5-6 membered heteroaryl group condensed into a 5-6 membered heterocyclyl group. more, [ka] And, more, [ka] And, more, [ka] That is the case. 【0023】 In some embodiments of the present invention, ring A is [ka] Selected from, preferably, [ka] Selected from. 【0024】 In some embodiments of the present invention, R is [ka] Selected from. 【0025】 In some embodiments of the present invention, the compound shown in formula (IA) above is as shown in formula (II), [ka] Here, M1 is selected from N or CR3. R1-1 or R 1-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 1-1 or R 1-2 These are linked to form a 3-8 membered heterocyclyl group or a 5-10 membered heteroaryl group, and the 3-8 membered heterocyclyl group or 5-10 membered heteroaryl group may optionally be further composed of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 2-1 and R 2-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R3 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) o1 Ure c1 ,-(CH2) o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHR d10 ) p2 C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 ) p5 NR d5 Rd6 ,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHR d10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) p1 Ure d1 ,-(CH2) p2 C(O)R d2 ,-(CH2) p3 NHC(O)R d3 ,-(CH2) p4 C(O)NHR d4 ,-(CH2) p5 NR d5 R d6 ,-(CH2) p6 S(O) p7 R d7 ,-(CH2) p8 S(O)2NHR d8 ,-(CH2) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R5 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) q1 Ure e1 ,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2) q8 S(O)2NHR e8 ,-(CH2) q9 NHS(O)2R e9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R a1 , R a2 , R a3 , R a4 , R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R c7 , R c8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 , R d8 , R d9 and R d10 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. x is 0, 1, 2, 3, 4, or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. 【0026】 In some embodiments of the present invention, R is [ka] That is the case. 【0027】 In some embodiments of the present invention, the aforementioned compound (II) is as shown in formula (II-1), [ka] Here, R 1-1 or R 1-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9NHS(O)2R a9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1-1 These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10w is selected from an aryl group or a 5- to 10-membered heteroaryl group, and w is selected from 0, 1, 2, 3, 4, 5, or 6. 【0028】 In some embodiments of the present invention, the aforementioned compound (II) is as shown in formula (II-1-1). [ka] 【0029】 In some embodiments of the present invention, the aforementioned compound (II) is as shown in formula (II-2), [ka] Here, R 1-1-1 These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from an aryl group or a 5-10 membered heteroaryl group, R 4-1-1 These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from an aryl group or a 5-10 membered heteroaryl group, w is selected from 0, 1, 2, 3, 4 or 5, y is selected from 0, 1, 2, 3, 4, 5 or 6, and z is selected from 0, 1, 2, 3, 4, 5 or 6. 【0030】 In some embodiments of the present invention, the aforementioned (II-2) compound is as shown in formula (II-2-1). [ka] 【0031】 In some embodiments of the present invention, the compound shown in formula (IA) above is as shown in formula (III), [ka] Here, M1 is selected from N or CR3. Ring B is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from an aryl group or a 5-14 membered heteroaryl group, or ring B is absent. [ka] teeth [ka] And, Ring C is C 3-6 Selected from cycloalkyl groups, 3-6 membered heterocyclyl groups, phenyl groups, or 5-6 membered heteroaryl groups, Ring D is C 3-6 Selected from cycloalkyl groups, 3-6 membered heterocyclyl groups, phenyl groups, or 5-6 membered heteroaryl groups, L1 is a bond, -O-, -NH-, -CO-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1 -, -C 1-3 Alkilen-NHS(O) r2 - or -C 1-3 Alkylene-S(O) r3 Selected from NH-, and the aforementioned -NH-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1 -, -C 1-3 Alkilen-NHS(O) r2 - or -C 1-3 Alkylene-S(O) r3 NH- can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups or 5-6 membered heteroaryl groups, R1 can independently be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-6Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-10 membered heteroaryl group. 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group substituents may optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 2-1 and R 2-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R3 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) o1 Ure c1 ,-(CH2) o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHRd10 ) p2 C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 ) p5 NR d5 R d6 ,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHR d10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) p1 Ure d1 ,-(CH2) p2 C(O)R d2 ,-(CH2) p3 NHC(O)R d3 ,-(CH2) p4 C(O)NHR d4 ,-(CH2) p5 NR d5 R d6 ,-(CH2) p6 S(O) p7 R d7 ,-(CH2) p8 S(O)2NHR d8 ,-(CH2) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R5 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) q1 Ure e1 ,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2) q8 S(O)2NHR e8 ,-(CH2) q9 NHS(O)2R e9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R a1 , R a2 , R a3 , R a4 , R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R c7 , R c8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 , R d8 , R d9 and R d10 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. x is 0, 1, 2, 3, 4, or 5. u is 0, 1, 2, 3, 4, or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, n9 are each independently selected from 0, 1, 2, 3, 4, 5 or 6, o1, o2, o3, o4, o5, o6, o8, o9 are each independently selected from 0, 1, 2, 3, 4, 5 or 6, p1, p2, p3, p4, p5, p6, p8, p9 are each independently selected from 0, 1, 2, 3, 4, 5 or 6, q1, q2, q3, q4, q5, q6, q8, q9 are each independently selected from 0, 1, 2, 3, 4, 5 or 6, m7, n7, o7, p7, q7 are each independently selected from 0, 1, 2 or 3, r1, r2, r3 are each independently selected from 0, 1 or 2. 【0032】 In some embodiments of the present invention, the compound shown in the foregoing formula (III) is as shown in formula (III-B). 【Chemical formula】 【0033】 In some embodiments of the present invention, the compound shown in the foregoing formula (III) is as shown in formula (III-B-1) or (III-B-2). 【Chemical formula】 【0034】 In some embodiments of the present invention, ring C is selected from 5- to 6-membered heteroaryl groups, preferably a 5-membered heteroaryl group, more preferably 【Chemical formula】 is. 【0035】 In some embodiments of the present invention, ring D is selected from 5- to 6-membered heteroaryl groups, preferably 【Chemical formula】 And, moreover, [ka] That is the case. 【0036】 In some embodiments of the present invention, the compounds shown in (III) above are as shown in (III-1), (III-2), (III-3), (III-4), (III-5), (III-6), (III-7), (III-8), (III-9), (III-10), or (III-11), [ka] R 4-1-1 These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The group is selected from an aryl group or a 5- to 10-membered heteroaryl group, and w is selected from 0, 1, 2, 3, 4, or 5. 【0037】 In some embodiments of the present invention, the compounds shown above as (III-1), (III-2), (III-3), (III-4), (III-5), (III-6), (III-7), (III-8), (III-9), (III-10), or (III-11) are as shown in (III-1-1), (III-2-1), (III-3-1), (III-4-1), (III-5-1), (III-6-1), (III-7-1), (III-8-1), (III-9-1), (III-10-1), or (III-11-1), respectively. [ka] 【0038】 In some embodiments of the present invention, the compound shown in formula (IA) above is as shown in formula (IV) or formula (IV-A), [ka] Here, M1 is selected from N or CR3. Ring B is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from an aryl group or a 5-14 membered heteroaryl group, or ring B is absent. [ka] teeth [ka] And, L1 is a bond, -O-, -NH-, -CO-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1 -, -C 1-3 Alkilen-NHS(O) r2 - or -C 1-3 Alkylene-S(O) r3 Selected from NH-, and the aforementioned -NH-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1 -, -C 1-3 Alkilen-NHS(O) r2 - or -C 1-3 Alkylene-S(O) r3 NH- can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups or 5-6 membered heteroaryl groups, R1 can independently be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2)m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further enriched with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF2, =CHF, =NOC 1-6 Alkyl alkyl group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-10 membered heteroaryl group. 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-10 The aryl group and 5-10 membered heteroaryl group substituents can optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF2, =CHF, =NOC 1-6 Alkyl alkyl group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Heteroalkyl groups, C 1-6 Deuterated heteroalkyl groups, C 1-6 Haloheteroalkyl groups, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, the C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Heteroalkyl groups, C 1-6 Deuterated heteroalkyl groups, C1-6 Haloheteroalkyl groups, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF2, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Heteroalkyl groups, C 1-6 Deuterated heteroalkyl groups, C 1-6 Haloheteroalkyl groups, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-10 membered heteroaryl group. 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group and the 5-10 membered heteroaryl group substituents may optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8A cycloalkyl group, a 3- to 8-member heterocyclyl group, C 6-10 may be substituted with one or more of an aryl group and a 5- to 10-member heteroaryl group, or, R 2-1 and R 2-2 are linked to form a C 3-8 cycloalkyl group, a 3- to 8-member heterocyclyl group, C 6-10 aryl group or a 5- to 10-member heteroaryl group, and the C 3-8 cycloalkyl group, a 3- to 8-member heterocyclyl group, C 6-10 aryl group and a 5- to 10-member heteroaryl group are optionally further substituted with hydrogen, deuterium, halogen, amino group, hydroxy group, cyano group, nitro group, oxo group, thio group, C 1-6 alkyl group, C 2-6 alkenyl group, C 2-6 alkynyl group, C 1-6 deuterated alkyl group, C 1-6 haloalkyl group, C 1-6 alkoxy group, C 1-6 deuterated alkoxy group, C 1-6 haloalkoxy group, C 1-6 hydroxyalkyl group, C 3-8 cycloalkyl group, a 3- to 8-member heterocyclyl group, C 6-10 may be substituted with one or more of an aryl group and a 5- to 10-member heteroaryl group, R3 is hydrogen, deuterium, halogen, amino group, hydroxy group, cyano group, nitro group, oxo group, thio group, C 1-6 alkyl group, C 2-6 alkenyl group, C 2-6 alkynyl group, C 1-6 deuterated alkyl group, C 1-6 haloalkyl group, C 1-6 alkoxy group, C 1-6 deuterated alkoxy group, C 1-6 haloalkoxy group, C 1-6 hydroxyalkyl group, C 3-8 cycloalkyl group, a 3- to 8-member heterocyclyl group, C 6-10 aryl group, a 5- to 10-member heteroaryl group, -(CH2) o1 OR c1 、-(CH2)o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1 and R 4-2These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHR d10 ) p2 C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 ) p5 NR d5 R d6 ,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHR d10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) p1 Ure d1 ,-(CH2) p2 C(O)R d2 ,-(CH2) p3 NHC(O)R d3 ,-(CH2) p4 C(O)NHR d4 ,-(CH2) p5 NR d5 R d6 ,-(CH2) p6S(O) p7 R d7 ,-(CH2) p8 S(O)2NHR d8 ,-(CH2) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R5 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) q1 Ure e1 ,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2) q8 S(O)2NHR e8 ,-(CH2)q9 NHS(O)2R e9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R a1 , R a2 , R a3 , R a4 , R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R c7 , Rc8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Rd1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 , R d8 and R d9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. x is 0, 1, 2, 3, 4, or 5, v is 1, 2, 3, or 4, and u is 0, 1, 2, 3, 4, or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. r1, r2, and r3 are each independently selected from 0, 1, or 2. 【0039】 In some embodiments of the present invention, the compound represented by formula (IV) above is as shown in formula (IV-1) or formula (IV-2), and the compound represented by formula (IV-A) above is as shown in formula (IV-A-1) or formula (IV-A-2). [ka] 【0040】 In some embodiments of the present invention, the compounds represented by formulas (IV-1), (IV-2), (IV-A-1), or (IV-A-2) are as shown in formulas (IV-1-1), (IV-2-1), (IV-A-3), or (IV-A-4). [ka] 【0041】 In some embodiments of the present invention, the compound shown in formula (IA) above is as shown in formula (V), [ka] Here, M1 is selected from N or CR3. Ring B is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from an aryl group or a 5-14 membered heteroaryl group, or ring B is absent. [ka] teeth [ka] And, L1 is a bond, -O-, -NH-, -CO-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1 -, -C 1-3 Alkilen-NHS(O) r2 - or -C 1-3 Alkylene-S(O) r3 Selected from NH-, and the aforementioned -NH-, -CONH-, C 1-3Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1 -, -C 1-3 Alkilen-NHS(O) r2 - or -C 1-3 Alkylene-S(O) r3 NH- can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups or 5-6 membered heteroaryl groups, R1 can independently be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) m1Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R3 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) o1 Ure c1 ,-(CH2) o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHR d10 ) p2 C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 ) p5 NR d5 R d6 ,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHRd10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) p1 Ure d1 ,-(CH2) p2 C(O)R d2 ,-(CH2) p3 NHC(O)R d3 ,-(CH2) p4 C(O)NHR d4 ,-(CH2) p5 NR d5 R d6 ,-(CH2) p6 S(O) p7 R d7 ,-(CH2) p8 S(O)2NHR d8 ,-(CH2) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R5 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) q1 Ure e1,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2) q8 S(O)2NHR e8 ,-(CH2) q9 NHS(O)2R e9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R a1 , R a2 , R a3 , R a4, R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R c7 , R c8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 , R d8 and R d9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. x is 0, 1, 2, 3, 4, or 5, v is 1, 2, 3, or 4, and u is 0, 1, 2, 3, 4, or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. r1, r2, and r3 are each independently selected from 0, 1, or 2. 【0042】 In some embodiments of the present invention, the compound shown in formula (V) above is as shown in formula (V-1). [ka] 【0043】 In some embodiments of the present invention, the compound shown in formula (V-1) above is as shown in formula (V-1-1). [ka] 【0044】 In some embodiments of the present invention, the compound shown in formula (I) above is as shown in formula (VII), [ka] Here, M1 is selected from N or CR3. Ring B is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from an aryl group or a 5-14 membered heteroaryl group, or ring B is absent. [ka] teeth [ka] And, L1 is a bond, -O-, -NH-, -CO-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1-, -C 1-3 Alkilen-NHS(O) r2 - or -C 1-3 Alkylene-S(O) r3 Selected from NH-, and the aforementioned -NH-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1 -, -C 1-3 Alkilen-NHS(O) r2 - or -C 1-3 Alkylene-S(O) r3 NH- can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups or 5-6 membered heteroaryl groups, R1 can independently be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-10 membered heteroaryl group. 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group substituents may optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 2-1 and R 2-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R3 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) o1 Ure c1 ,-(CH2) o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHR d10 ) p2 C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 )p5 NR d5 R d6 ,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHR d10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R5 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) q1 Ure e1 ,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2)q8 S(O)2NHR e8 ,-(CH2) q9 NHS(O)2R e9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R a1 , R a2 , R a3 , R a4 , R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R c1 , R c2, R c3 , R c4 , R c5 , R c6 , R c7 , R c8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 , R d8 , R d9 and R d10 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. x is 0, 1, 2, 3, 4, or 5, v is 1, 2, 3, or 4, and u is 0, 1, 2, 3, 4, or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. r1, r2, and r3 are each independently selected from 0, 1, or 2. 【0045】 In some embodiments of the present invention, the compound represented by formula (VII) is as shown in formula (VII-1) or formula (VII-2). [ka] 【0046】 In some embodiments of the present invention, the compound represented by formula (VII) is as shown in formula (VII-1-1) or formula (VII-2-1). [ka] 【0047】 In some embodiments of the present invention, the compound shown in formula (I) above is as shown in formula (VIII) or (IX), [ka] Here, M1 is selected from N or CR3, M2 is selected from N or CH, and M3 is selected from N or CH. Ring B is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from an aryl group or a 5-14 membered heteroaryl group, or ring B is absent. [ka] teeth [ka] And, L1 is a bond, -O-, -NH-, -CO-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1 -, -C 1-3 Alkilen-NHS(O)r2 - or -C 1-3 Alkylene-S(O) r3 Selected from NH-, and the aforementioned -NH-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r1 -, -C 1-3 Alkilen-NHS(O) r2 - or -C 1-3 Alkylene-S(O) r3 NH- can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups or 5-6 membered heteroaryl groups, R1 can independently be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-10 membered heteroaryl group. 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group substituents may optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 2-1 and R 2-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R3 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) o1 Ure c1 ,-(CH2) o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHR d10 ) p2 C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 )p5 NR d5 R d6 ,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHR d10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R5 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) q1 Ure e1 ,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2)q8 S(O)2NHR e8 ,-(CH2) q9 NHS(O)2R e9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R a1 , R a2 , R a3 , R a4 , R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R c1 , R c2, R c3 , R c4 , R c5 , R c6 , R c7 , R c8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 , R d8 , R d9 and R d10 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. x is 0, 1, 2, 3, 4 or 5, and u is 0, 1, 2, 3, 4 or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. r1, r2, and r3 are each independently selected from 0, 1, or 2. 【0048】 In some embodiments of the present invention, the compounds represented by formula (VIII) or (IX) described above are as shown in formula (VIII-1) or formula (IX-1). [ka] 【0049】 In some embodiments of the present invention, the compound represented by formula (VIII-1) or formula (IX-1) is as shown in formula (VIII-1-1) or formula (IX-1-1). [ka] 【0050】 In some embodiments of the present invention, the compounds are as shown in (I-AAA). [ka] L2 is a bond, -O-, -NH-, -CO-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r4 -, -C 1-3 Alkilen-NHS(O) r5 - or -C 1-3 Alkylene-S(O) r6 Selected from NH-, and the aforementioned -NH-, -CONH-, C 1-3 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -OC 1-3 Alkylene-, -SC 1-3 Alkylene-,-C 1-3 Alkylene-NH-,-C 1-3 Alkylene-C(O)NH-,-C 1-3 Alkylene-NHC(O)-,-C 1-3 Alkylene-S(O) r4 -, -C 1-3Alkilen-NHS(O) r5 - or -C 1-3 Alkylene-S(O) r6 NH- can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups or 5-6 membered heteroaryl groups, Ring E is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, preferably 3-12 membered heterocyclyl groups. R 2-1-1 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF2, =CHF, =NOC 1-6 Alkyl alkyl group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Heteroalkyl groups, C 1-6 Deuterated heteroalkyl groups, C 1-6 Haloheteroalkyl groups, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10Selected from an aryl group or a 5-10 membered heteroaryl group, where the C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Heteroalkyl groups, C 1-6 Deuterated heteroalkyl groups, C 1-6 Haloheteroalkyl groups, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF2, =CHF, =NOC 1-6 Alkyl alkyl group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Heteroalkyl groups, C 1-6 Deuterated heteroalkyl groups, C 1-6 Haloheteroalkyl groups, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, R 2-1-1Preferably, the group is a methyl group, an ethyl group, a methoxy group, F, =CF2, -CHF2, -CH2F, -CF3, -CH2CHF2, -CHF2CH3, -CH2CF3, -CH2OCH3, -CH2OCD3, -CH2OCF3, -CH2O cyclopropyl group, -CH2SCF3, a cyclopropyl group, a cyclobutyl group, OCD3, or OCF3. j is 0, 1, 2, 3, 4, or 5, and r4, r5, and r6 are each independently selected from 0, 1, or 2. v is 1, 2, 3, or 4. 【0051】 In some embodiments of the present invention, the compounds are as shown in (I-AAA), [ka] v is 1, 2, 3, or 4. 【0052】 In some embodiments of the present invention, the compound is as shown in (I-AA-1) or (I-AA-2), [ka] Here, R 4-1-1 These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 w is selected from an aryl group or a 5- to 10-membered heteroaryl group, and w is selected from 0, 1, 2, 3, 4, 5, or 6. 【0053】 In some embodiments of the present invention, ring B is C 3-6 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from an aryl group or a 5-10 membered heteroaryl group, or ring B is absent, preferably ring B is C 3-6 Selected from a cycloalkyl group, a phenyl group, or a 5-6 membered heteroaryl group, or ring B is absent, more preferably ring B is [ka] Selected from, or ring B does not exist, more preferably ring B is [ka] Selected from, or ring B is absent. In some embodiments of the present invention, ring B is [ka] Selected from. In some embodiments of the present invention, ring B is [ka] Selected from. 【0054】 In some embodiments of the present invention, the compound is as shown in (I-AA), (I-AA-3), or (I-AA-4), [ka] v is 1, 2, 3, or 4. 【0055】 In some embodiments of the present invention, L1 is selected from a bond, O, or -CF2-. In some embodiments of the present invention, L1 is selected from a bond. In some embodiments of the present invention, L1 is selected from O. In some embodiments of the present invention, L1 is selected from a bond or -CF2-. 【0056】 In some embodiments of the present invention, R is [ka] That is the case. 【0057】 In some embodiments of the present invention, the compound shown in formula (IA) above is as shown in formula (VI), [ka] Here, M1 is selected from N or CR3. R 1-3 These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 ,-(CH2) m10 R a10 Selected from, the amino group, C 1-6 Alkyl alkyl group, C2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-10 membered heteroaryl group. 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group and the 5-10 membered heteroaryl group substituents may optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Substituted with one or more aryl groups and 5-10 membered heteroaryl groups, Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 2-1 and R 2-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R3 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) o1 Ure c1 ,-(CH2)o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R 4-1 and R 4-2These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHR d10 ) p2 C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 ) p5 NR d5 R d6 ,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHR d10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Preferably, R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) p1 Ure d1 ,-(CH2) p2 C(O)R d2 ,-(CH2) p3 NHC(O)R d3 ,-(CH2) p4 C(O)NHR d4 ,-(CH2) p5 NR d5 R d6 ,-(CH2) p6S(O) p7 R d7 ,-(CH2) p8 S(O)2NHR d8 ,-(CH2) p9 NHS(O)2R d9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R5 consists of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Aryl group, 5-10 membered heteroaryl group, -(CH2) q1 Ure e1 ,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2) q8 S(O)2NHR e8 ,-(CH2)q9 NHS(O)2R e9 Selected from, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R a1 , R a2 , R a3 , R a4 , R a5 , R a6 , R a7 , R a8 , R a9 and R a10 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R c1 , R c2 , R c3 , R c4 , R c5 , R c6, R c7 , R c8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 , R d8 , R d9 and R d10 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-6 Alkyl alkyl group, C2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Deuterated alkyl group, C 1-6 Haloalkyl group, C 1-6 Alkoxy group, C 1-6 Deuterated alkoxy group, C 1-6 Haloalkoxy group, C 1-6 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. x is 0, 1, 2, 3, 4 or 5, and u is 0, 1, 2, 3, 4 or 5. m1, m2, m3, m4, m5, m6, m8, m9, and m10 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. 【0058】 In some embodiments of the present invention, the compound shown in formula (VI) above is as shown in formula (VI-1), and in some embodiments of the present invention, the compound shown in formula (VI-1) above is as shown in formula (VI-1-1). [ka] 【0059】 In some embodiments of the present invention, R1 is independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 member heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. R a1 , R a2 , R a3 , R a4 , R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. Preferably, R1 is hydrogen, deuterium, oxo group, trifluoromethyl group, fluorine, chlorine, bromine, -CH2CF3, cyano group, methoxy group, -CH=CF2, -CH2CHF2, preferably, R1 is hydrogen, deuterium, oxo group, trifluoromethyl group, fluorine, chlorine, -CH2CF3, cyano group, methoxy group, -CH=CF2, -CH2CHF2, preferably, R1 is hydrogen, deuterium, oxo group, trifluoromethyl group, fluorine, -CH2CF3, cyano group, methoxy group, -CH=CF2, -CH2CHF2, and more preferably, R1 is oxo group, trifluoromethyl group, fluorine, -CH2CF3, cyano group. 【0060】 In some embodiments of the present invention, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 member heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further enriched with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF2, =CHF, =NOC 1-3 Alkyl alkyl group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group and 5-6 membered heteroaryl group substituents can optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF2, =CHF, =NOC 1-3 Alkyl alkyl group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Heteroalkyl groups, C 1-3 Deuterated heteroalkyl groups, C 1-3 Haloheteroalkyl groups, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It is substituted with one or more aryl groups and 5-6 membered heteroaryl groups. 【0061】 In some embodiments of the present invention, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 member heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The C may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group and 5-6 membered heteroaryl group substituents can optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It is substituted with one or more aryl groups and 5-6 membered heteroaryl groups. 【0062】 In some embodiments of the present invention, R 2-1 and R 2-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 member heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. Preferably, R 2-1 and R 2-2These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 member heteroaryl group, -(CH2) n1 Ure b1 ,-(CH2) n2 C(O)R b2 ,-(CH2) n3 NHC(O)R b3 ,-(CH2) n4 C(O)NHR b4 ,-(CH2) n5 NR b5 R b6 ,-(CH2) n6 S(O) n7 R b7 ,-(CH2) n8 S(O)2NHR b8 ,-(CH2) n9 NHS(O)2R b9 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. Or, R 2-1 and R 2-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. R b1 , R b2 , R b3 , R b4 , R b5 , R b6 , R b7 , R b8 and R b9These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. 【0063】 In some embodiments of the present invention, the C of the group described in each general formula 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group and 5-6 membered heteroaryl group substituents can optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. 【0064】 In some embodiments of the present invention, R 2-1 teeth, [ka] Selected from, preferably, ring E is [ka] Here, ring E' is selected from 3-12 membered heterocyclyl groups, preferably a 3-8 membered monocyclic heterocyclyl group, a 3-8 membered fused heterocyclyl group, a 3-8 membered bridged heterocyclyl group, or a 3-8 membered spiro-ring heterocyclyl group, more preferably a 3-8 membered monocyclic heterocyclyl group, a 3-8 membered fused heterocyclyl group, or a 3-8 membered spiro-ring heterocyclyl group, preferably a 5-9 membered heterocyclyl group, more preferably a 5-6 membered heterocyclyl group, and preferably ring E' is [ka] Selected from. 【0065】 In some embodiments of the present invention, L2 is CH2. 【0066】 In some embodiments of the present invention, R 2-1 teeth, [ka] Selected from. In some embodiments of the present invention, preferably R 2-1 is hydrogen, methyl group, [ka] Cyclopropyl group, -CH=cf2, -CH2-cyclopropyl group, -OCH2OCD3, -CH2OCD3, -CH2OCHF2, -CH2COOCH2CH3, -CH2COOH, -CH2CH2COOH, CH2N(CH3)2, [ka] Selected from. In some embodiments of the present invention, R 2-1 is hydrogen, methyl group, [ka] Cyclopropyl group, -CH=cf2, -CH2-cyclopropyl group, -OCH2OCD3, -CH2OCD3, -CH2OCHF2, -CH2COOCH2CH3, -CH2COOH, -CH2CH2COOH, CH2N(CH3)2, [ka] Selected from. In some embodiments of the present invention, R 2-1 is hydrogen, methyl group, [ka] Cyclopropyl group, -CH=cf2, -CH2-cyclopropyl group, -OCH2OCD3, -CH2OCD3, -CH2OCHF2, -CH2COOCH2CH3, -CH2COOH, -CH2CH2COOH, [ka] Selected from. In some embodiments of the present invention, R 2-1 is hydrogen, methyl group, [ka] Cyclopropyl group, -CH=cf2, -CH2-cyclopropyl group, -OCH2OCD3, -CH2OCD3, -CH2OCHF2, -CH2COOCH2CH3, -CH2COOH, -CH2CH2COOH, [ka] Selected from. 【0067】 In some embodiments of the present invention, R 2-1 is hydrogen, methyl group, [ka] Selected from cyclopropyl group, -CH=CF2, -CH2-cyclopropyl group, -OCH2OCD3, -CH2OCD3, and -CH2OCHF2. In some embodiments of the present invention, R 2-1 is hydrogen, methyl group, [ka] Selected from cyclopropyl group, -CH=CF2, -CH2-cyclopropyl group, -OCH2OCD3, and -CH2OCD3. In some embodiments of the present invention, R 2-1 is hydrogen, methyl group, [ka] Selected from cyclopropyl groups. 【0068】 In some embodiments of the present invention, R 2-2 R is selected from hydrogen. In some embodiments of the present invention, R 2-2 This is selected from hydrogen or a methyl group. 【0069】 In some embodiments of the present invention, R3 is independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 member heteroaryl group, -(CH2) o1 Ure c1 ,-(CH2) o2 C(O)R c2 ,-(CH2) o3 NHC(O)R c3 ,-(CH2) o4 C(O)NHR c4 ,-(CH2) o5 NR c5 R c6 ,-(CH2) o6 S(O) o7 R c7 ,-(CH2) o8 S(O)2NHR c8 ,-(CH2) o9 NHS(O)2R c9 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R c7 , R c8 and R c9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. Preferably, R3 is independently hydrogen. 【0070】 In some embodiments of the present invention, R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 membered heteroaryl group, -(CHR d10 ) p1 Ure d1 ,-(CHR d10 ) p2C(O)R d2 ,-(CHR d10 ) p3 NHC(O)R d3 ,-(CHR d10 ) p4 C(O)NHR d4 ,-(CHR d10 ) p5 NR d5 R d6 ,-(CHR d10 ) p6 S(O) p7 R d7 ,-(CHR d10 ) p8 S(O)2NHR d8 ,-(CHR d10 ) p9 NHS(O)2R d9 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. Preferably, R 4-1 and R 4-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 member heteroaryl group, -(CH2) p1 Ure d1 ,-(CH2) p2 C(O)R d2 ,-(CH2) p3 NHC(O)R d3 ,-(CH2) p4 C(O)NHR d4 ,-(CH2) p5 NR d5 R d6 ,-(CH2) p6 S(O) p7 R d7 ,-(CH2) p8 S(O)2NHR d8 ,-(CH2) p9 NHS(O)2R d9 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-8 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. Or, R 4-1 and R 4-2 It is connected to C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 Forming an aryl group or a 5-10 membered heteroaryl group, the C 3-8 Cycloalkyl group, 3-8 membered heterocyclyl group, C 6-10 The aryl group and the 5-10 membered heteroaryl group can optionally be further modified with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. R d1 , R d2 , R d3 , R d4 , R d5 , Rd6 , R d7 , R d8 and R d9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. 【0071】 In some embodiments of the present invention, R 4-1 teeth, [ka] Selected from. In some embodiments of the present invention, R 4-1 teeth, [ka] Selected from. In some embodiments of the present invention, R 4-1 teeth, [ka] Selected from. In some embodiments of the present invention, R 4-1 teeth, [ka] Selected from. In some embodiments of the present invention, R 4-1 teeth, [ka] Selected from. In some embodiments of the present invention, R 4-1 teeth, [ka] Select from, or [ka] Selected from, or in some embodiments of the present invention, R 4-1 teeth, [ka] Selected from. In some embodiments of the present invention, R 4-1 teeth, [ka] selected from. In some embodiments of the present invention, R 4-1 is 【Chemical formula】 selected from. In some embodiments of the present invention, R 4-1 is 【Chemical formula】 selected from. In some embodiments of the present invention, R 4-1 is 【Chemical formula】 selected from. In some embodiments of the present invention, R 4-1 is 【Chemical formula】 selected from. In some embodiments of the present invention, R 4-1 is 【Chemical formula】 selected from. 【0072】 In some embodiments of the present invention, R 4-2 is selected from hydrogen. 【0073】 In some embodiments of the present invention, R5 is hydrogen, deuterium, halogen, amino group, hydroxy group, cyano group, nitro group, oxo group, thio group, C 1-3 alkyl group, C 2-4 alkenyl group, C 2-4 alkynyl group, C 1-3 deuterated alkyl group, C 1-3 haloalkyl group, C 1-3 alkoxy group, C 1-3 deuterated alkoxy group, C 1-3 haloalkoxy group, C 1-3 hydroxyalkyl group, C 3-6Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 member heteroaryl group, -(CH2) q1 Ure e1 ,-(CH2) q2 C(O)R e2 ,-(CH2) q3 NHC(O)R e3 ,-(CH2) q4 C(O)NHR e4 ,-(CH2) q5 NR e5 R e6 ,-(CH2) q6 S(O) q7 R e7 ,-(CH2) q8 S(O)2NHR e8 ,-(CH2) q9 NHS(O)2R e9 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. R e1 , R e2 , R e3 , R e4 , R e5 , R e6 , R e7 , R e8 and R e9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. Preferably, R5 is hydrogen, fluorine, methyl group, isopropyl group, [ka] R5 is selected from trifluoromethyl group, monofluoromethyl group, cyano group, cyclopropyl group, and ethyl group, and more preferably R5 is hydrogen, fluorine, methyl group, isopropyl group, [ka] A trifluoromethyl group, a monofluoromethyl group, or a cyano group is selected. In some embodiments of the present invention, preferably R5 is hydrogen, fluorine, a methyl group, an isopropyl group, [ka] Trifluoromethyl group, monofluoromethyl group, cyano group, cyclopropyl group, ethyl group, deuterated ethyl group, deuterated methyl group, cyclobutyl group, cyclopentyl group, cyclohexyl group, [ka] Selected from. 【0074】 In some embodiments of the present invention, R 4-1-1 These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-6 membered heteroaryl groups, Preferably, R 4-1-1 These are independently selected from hydrogen, fluorine, and methyl groups. 【0075】 In some embodiments of the present invention, R 1-1 or R 1-2 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 member heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)R a3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. R a1 , R a2 , R a3 , R a4 , R a5 , R a6 , R a7 , R a8 and R a9 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. 【0076】 In some embodiments of the present invention, R 1-1 or R 1-2 These are linked together to form a 3-6 membered heterocyclyl group, and the 3-6 membered heterocyclyl group can optionally be further composed of hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. 【0077】 In some embodiments of the present invention, R 1-1 or R 1-2 Each of them independently has a methyl group, [ka] Selected from. 【0078】 In some embodiments of the present invention, R 1-1 or R 1-2 They are connected [ka] It forms. 【0079】 In some embodiments of the present invention, R 1-3 These are hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Aryl group, 5-6 member heteroaryl group, -(CH2) m1 Ure a1 ,-(CH2) m2 C(O)R a2 ,-(CH2) m3 NHC(O)Ra3 ,-(CH2) m4 C(O)NHR a4 ,-(CH2) m5 NR a5 R a6 ,-(CH2) m6 S(O) m7 R a7 ,-(CH2) m8 S(O)2NHR a8 ,-(CH2) m9 NHS(O)2R a9 ,-(CH2) m10 R a10 Selected from, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. R a1 , R a2 , R a3 , R a4 , R a5 , R a6, R a7 , R a8 , R a9 and R a10 These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10It may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. Preferably, R 1-3 teeth, [ka] Selected from. 【0080】 In some embodiments of the present invention, R 1-1-1 These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C 1-3 Alkyl alkyl group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, C 1-3 Deuterated alkyl group, C 1-3 Haloalkyl group, C 1-3 Alkoxy group, C 1-3 Deuterated alkoxy group, C 1-3 Haloalkoxy group, C 1-3 Hydroxyalkyl group, C 3-6 Cycloalkyl group, 3-6 membered heterocyclyl group, C 6-10 Selected from an aryl group or a 5-6 membered heteroaryl group, preferably R 1-1-1 This is independently selected from hydrogen, a trifluoromethyl group, or fluorine. 【0081】 In some embodiments of the present invention, the compound is as shown in (IE). [ka] Here, The ring Het is C 3-12 Cycloalkyl group, 3-12 membered heterocyclyl group, C 6-14 Selected from an aryl group or a 5-14 membere...

Claims

[Claim 1] A compound shown in formula (I-A), its stereoisomer, or a pharmaceutically acceptable salt thereof, 【Chemistry 1】 Here, M １ is N or CR ３ Selected from, L １ is selected from bonding, -O-, -NH-, -CO-, -CONH-, C １－３ alkylene group, C ２－４ alkenylene group, C ２－４ alkynylene group, -O-C １－３ alkylene-, -S-C １－３ alkylene-, -C １－３ alkylene-NH-, -C １－３ alkylene-C(O)NH-, -C １－３ alkylene-NHC(O)-, -C １－３ alkylene-S(O) ｒ１ -, -C １－３ alkylene-NHS(O) ｒ２ - or -C １－３ alkylene-S(O) ｒ３ NH-, and the -NH-, -CONH-, C １－３ alkylene group, C ２ －４ alkenylene group, C ２－４ alkynylene group, -O-C １－３ alkylene-, -S-C １－３ alkylene-, -C １－３ alkylene-NH-, -C １－３ alkylene-C(O)NH-, -C １－３ alkylene-NHC(O)-, -C １－３ alkylene-S(O) ｒ１ -, -C １－３ alkylene-NHS(O) ｒ２ - or -C １－３ alkylene-S(O) ｒ ３ NH- is optionally hydrogen, deuterium, halogen, amino group, hydroxy group, cyano group, nitro group, oxo group, thio group, C １－３ alkyl group, C ２－４ alkenyl group, C ２－ ４ alkynyl group, C １－３ deuterated alkyl group, C １－３ haloalkyl group, C １－３ alkoxy group, C １－３ deuterated alkoxy group, C １－３ haloalkoxy group, C １－３ hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Substituted with one or more aryl groups or 5-6 membered heteroaryl groups, preferably bonded. Ring B is C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１４ Selected from an aryl group or a 5- to 14-membered heteroaryl group, or ring B is absent. R is C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－１ ２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１４ Selected from an aryl group or a 5- to 14-membered heteroaryl group, the C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６ －１４ The aryl group or 5-14 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １ －６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ２－１ and R ２－２ are each independently hydrogen, deuterium, a halogen, an amino group, a hydroxy group, a cyano group, a nitro group, an oxo group, a thio group, C １－６ alkyl group, C ２－６ alkenyl group, C ２－６ alkynyl group, C １－６ deuterated alkyl group, C １－６ haloalkyl group, C １－６ alkoxy group, C １－６ deuterated alkoxy group, C １－６ haloalkoxy group, C １－６ hydroxyalkyl group, C ３－８ cycloalkyl group, 3- to 8-membered heterocyclyl group, C ６－１０ aryl group, 5- to 10-membered heteroaryl group, -(CH ２ ) ｎ１ OR ｂ１ , -(CH ２ ) ｎ２ C(O)R ｂ２ , -(CH ２ ) ｎ３ NHC(O)R ｂ３ , -(CH ２ ) ｎ４ C(O)NHR ｂ４ , -(CH ２ ) ｎ５ NR ｂ５ R ｂ６ , -(CH<\(0000113\)>) ｎ６ S(O) ｎ７ R ｂ７ , -(CH ２ ) ｎ８ S(O) ２ NHR ｂ８ , -(CH ２ ) ｎ９ NHS(O) ２ R ｂ９ selected from, said amino group, C １－６ alkyl group, C ２－６ alkenyl group, C ２－６ alkynyl group, C １－６ deuterated alkyl group, C １－６ haloalkyl group, C １－６ alkoxy group, C １－６ deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１ ０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. Or, R ２－１ and R ２－２ It is connected to C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Forming an aryl group or a 5-10 membered heteroaryl group, the C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group may optionally be further enriched with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. Or, R and R ２－２ It is connected to C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Forming an aryl group or a 5-10 membered heteroaryl group, the C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group may optionally be further enriched with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ３ These are hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－ ６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｏ１ OR ｃ１ ,-(CH ２ ) ｏ２ C(O)R ｃ２ ,-(CH ２ ) ｏ３ NHC(O)R ｃ３ ,-(CH ２ ) ｏ４ C(O)NHR ｃ４ ,-(CH ２ ) ｏ５ NR ｃ５ R ｃ６ ,-(CH ２ ) ｏ６ S(O) ｏ７ R ｃ７ ,-(CH ２ ) ｏ８ S(O) ２ NHR ｃ８ ,-(CH ２ ) ｏ９ NHS (O) ２ R ｃ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－ ６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－ １０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ４－１ and R ４－２ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｐ１ OR ｄ１ ,-(CH ２ ) ｐ２ C(O)R ｄ２ ,-(CH ２ ) ｐ３ NHC(O)R ｄ３ ,-(CH ２ ) ｐ４ C(O)NHR ｄ４ ,-(CH ２ ) ｐ５ NR ｄ５ R ｄ６ ,-(CH ２ ) ｐ６ S(O) ｐ７ R ｄ７ ,-(CH ２ ) ｐ８ S(O) ２ NHR ｄ８ ,-(CH ２ ) ｐ９ NHS (O) ２ R ｄ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１ ０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. Or, R ４－１ and R ４－２ It is connected to C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Forming an aryl group or a 5-10 membered heteroaryl group, the C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ５ These are hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－ ６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｑ１ OR ｅ１ ,-(CH ２ ) ｑ２ C(O)R ｅ２ ,-(CH ２ ) ｑ３ NHC(O)R ｅ３ ,-(CH ２ ) ｑ４ C(O)NHR ｅ４ ,-(CH ２ ) ｑ５ NR ｅ５ R ｅ６ ,-(CH ２ ) ｑ６ S(O) ｑ７ R ｅ７ ,-(CH ２ ) ｑ８ S(O) ２ NHR ｅ８ ,-(CH ２ ) ｑ９ NHS (O) ２ R ｅ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－ ６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－ １０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ６ and R ７ These are, independently, hydrogen and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １ －６ Hydroxyalkyl group, C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１４ Selected from an aryl group or a 5- to 14-membered heteroaryl group, the C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１４ The aryl group or 5-14 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ａ１ , R ａ２ , R ａ３ , R ａ４ , R ａ５ , R ａ６ , R ａ７ , R ａ８ and R ａ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C １－６ alkyl group, C ２－ ６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－ ６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ｂ１ , R ｂ２ , R ｂ３ , R ｂ４ , R ｂ５ , R ｂ６ , R ｂ７ , R ｂ８ and R ｂ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C １－６ alkyl group, C ２－ ６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－ ６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ｃ１ , R ｃ２ , R ｃ３ , R ｃ４ , R ｃ５ , R ｃ６ , R ｃ７ , R ｃ８ and R ｃ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C １－６ alkyl group, C ２－ ６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－ ６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ , R ｄ８ and R ｄ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C １－６ alkyl group, C ２－ ６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－ ６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ｅ１ , R ｅ２ , R ｅ３ , R ｅ４ , R ｅ５ , R ｅ６ , R ｅ７ , R ｅ８ and R ｅ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C １－６ alkyl group, C ２－ ６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－ ６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. u is 0, 1, 2, 3, 4, or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. r1, r2, and r3 are each independently selected from 0, 1, or 2, and are compounds, stereoisomers thereof, or pharmaceutically acceptable salts thereof. [Claim 2] R ２－１ and R ２－２ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｎ１ OR ｂ１ ,-(CH ２ ) ｎ２ C(O)R ｂ２ ,-(CH ２ ) ｎ３ NHC(O)R ｂ３ ,-(CH ２ ) ｎ４ C(O)NHR ｂ４ ,-(CH ２ ) ｎ５ NR ｂ５ R ｂ６ ,-(CH ２ ) ｎ６ S(O) ｎ７ R ｂ７ ,-(CH ２ ) ｎ８ S(O) ２ NHR ｂ８ ,-(CH ２ ) ｎ９ NHS (O) ２ R ｂ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１ ０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The C may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group substituents may optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The compound according to claim 1, characterized by being substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. [Claim 3] The compound is as shown in (I-A-1), 【Chemistry 2】 Here, Ring A is C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１４ Selected from an aryl group or a 5- to 14-membered heteroaryl group, R １ These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｍ１ OR ａ１ ,-(CH ２ ) ｍ２ C(O)R ａ２ ,-(CH ２ ) ｍ３ NHC(O)R ａ３ ,-(CH ２ ) ｍ４ C(O)NHR ａ４ ,-(CH ２ ) ｍ５ NR ａ５ R ａ６ ,-(CH ２ ) ｍ６ S(O) ｍ７ R ａ７ ,-(CH ２ ) ｍ８ S(O) ２ NHR ａ８ ,-(CH ２ ) ｍ９ NHS (O) ２ R ａ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １ －６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３ －８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. M １ is N or CR ３ Selected from, L １ These are bonds, -O-, -NH-, -CO-, -CONH-, C １－３ Alkylene group, C ２－４ Alkenylene group, C ２－４ Alkynylene group, -O-C １－３ Alkylene-,-S-C １－３ Alkylene-, -C １－３ Alkylene-NH-,-C １－３ Alkylene-C(O)NH-,-C １－３ Alkylene-NHC(O)-,-C １－３ Alkylene-S(O) ｒ１ -, -C １－３ Alkylene-NHS(O) ｒ２ - or -C １－３ Alkylene-S(O) ｒ３ Selected from NH-, and the aforementioned -NH-, -CONH-, C １－３ Alkylene group, C ２ －４ Alkenylene group, C ２－４ Alkynylene group, -O-C １－３ Alkylene-,-S-C １－３ Alkylene-, -C １－３ Alkylene-NH-,-C １－３ Alkylene-C(O)NH-,-C １－３ Alkylene-NHC(O)-,-C １－３ Alkylene-S(O) ｒ１ -, -C １－３ Alkylene-NHS(O) ｒ２ - or -C １－３ Alkylene-S(O) ｒ ３ NH- can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－ ４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Substituted with one or more aryl groups or 5-6 membered heteroaryl groups, preferably bonded. Ring B is C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１４ Selected from an aryl group or a 5- to 14-membered heteroaryl group, or ring B is absent. R ２－１ and R ２－２ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｎ１ OR ｂ１ ,-(CH ２ ) ｎ２ C(O)R ｂ２ ,-(CH ２ ) ｎ３ NHC(O)R ｂ３ ,-(CH ２ ) ｎ４ C(O)NHR ｂ４ ,-(CH ２ ) ｎ５ NR ｂ５ R ｂ６ ,-(CH ２ ) ｎ６ S(O) ｎ７ R ｂ７ ,-(CH ２ ) ｎ８ S(O) ２ NHR ｂ８ ,-(CH ２ ) ｎ９ NHS (O) ２ R ｂ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １ －６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ A haloalkoxy group, C １－ ６ A hydroxyalkyl group, C ３－１２ A cycloalkyl group, a 3- to 12-member heterocyclyl group, C ６－１０ An aryl group or a 5- to 10-member heteroaryl group may optionally further be hydrogen, deuterium, halogen, an amino group, a hydroxy group, a cyano group, a nitro group, a carboxyl group, an oxo group, a thio group, =CF ２ , =CHF, =NOC １－６ An alkyl group, C １－６ An alkyl group, C ２－６ An alkenyl group, C ２－６ An alkynyl group, C １－６ A deuterated alkyl group, C １－ ６ A haloalkyl group, C １－６ An alkoxy group, C １－６ A deuterated alkoxy group, C １－６ A haloalkoxy group, C １－６ A hydroxyalkyl group, C ３－１２ A cycloalkyl group, a 3- to 12-member heterocyclyl group, C ６－１０ An aryl group and a 5- to 10-member heteroaryl group may be substituted with one or more of them, and the C ３－１２ A cycloalkyl group, a 3- to 12-member heterocyclyl group, C ６－１０ An aryl group and a 5- to 10-member heteroaryl group substituents may optionally further be hydrogen, deuterium, halogen, an amino group, a hydroxy group, a cyano group, a nitro group, a carboxyl group, an oxo group, a thio group, =CF ２ , =CHF, =NOC １－６ An alkyl group, C １－６ An alkyl group, C ２－６ An alkenyl group, C ２－６ An alkynyl group, C １－６ A deuterated alkyl group, C １－６ A haloalkyl group, C １－６ An alkoxy group, C １－６ A deuterated alkoxy group, C １－６ A haloalkoxy group, C １－６ A heteroalkyl group, C １－６ A deuterated heteroalkyl group, C １－６ A haloheteroalkyl group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups, the C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Heteroalkyl groups, C １－６ Deuterated heteroalkyl groups, C １－６ Haloheteroalkyl groups, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF ２ , C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Heteroalkyl groups, C １－６ Deuterated heteroalkyl groups, C １－６ Haloheteroalkyl groups, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups, Preferably, R ２－１ and R ２－２ are each independently hydrogen, deuterium, halogen, an amino group, a hydroxy group, a cyano group, a nitro group, an oxo group, a thio group, C １－６ alkyl group, C ２－６ alkenyl group, C ２－６ alkynyl group, C １－６ deuterated alkyl group, C １－ ６ haloalkyl group, C １－６ alkoxy group, C １－６ deuterated alkoxy group, C １－６ haloalkoxy group, C １－６ hydroxyalkyl group, C ３－８ cycloalkyl group, 3- to 8-membered heterocyclyl group, C ６－１０ aryl group, 5- to 10-membered heteroaryl group, -(CH ２ ) ｎ１ OR ｂ１ , -(CH ２ ) ｎ２ C(O)R ｂ２ , -(CH ２ ) ｎ３ NHC(O)R ｂ３ , -(CH ２ ) ｎ４ C(O)NHR ｂ４ , -(CH ２ ) ｎ５ NR ｂ５ R ｂ６ , -(CH ２ ) ｎ６ S(O) ｎ７ R ｂ７ , -(CH ２ ) ｎ８ S(O) ２ NHR ｂ８ , -(CH ２ ) ｎ９ NHS(O) ２ R ｂ９ selected from, and the amino group, C １－６ alkyl group, C ２－６ alkenyl group, C ２－６ alkynyl group, C １－６ deuterated alkyl group, C １－６ haloalkyl group, C １－６ alkoxy group, C １－６ deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The C may be substituted with one or more of an aryl group and a 5- to 10-membered heteroaryl group. ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group substituents may optionally be further hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １ －６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups, Preferably, R ２－１ and R ２－２ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－ ６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｎ１ OR ｂ１ ,-(CH ２ ) ｎ２ C(O)R ｂ２ ,-(CH ２ ) ｎ３ NHC(O)R ｂ３ ,-(CH ２ ) ｎ４ C(O)NHR ｂ４ ,-(CH ２ ) ｎ５ NR ｂ５ R ｂ６ ,-(CH ２ ) ｎ６ S(O) ｎ７ R ｂ７ ,-(CH ２ ) ｎ８ S(O) ２ NHR ｂ８ ,-(CH ２ ) ｎ９ NHS (O) ２ R ｂ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. Or, R ２－１ and R ２－２ It is connected to C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Forming an aryl group or a 5-10 membered heteroaryl group, the C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group may optionally be further enriched with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ３ These are hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－ ６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｏ１ OR ｃ１ ,-(CH ２ ) ｏ２ C(O)R ｃ２ ,-(CH ２ ) ｏ３ NHC(O)R ｃ３ ,-(CH ２ ) ｏ４ C(O)NHR ｃ４ ,-(CH ２ ) ｏ５ NR ｃ５ R ｃ６ ,-(CH ２ ) ｏ６ S(O) ｏ７ R ｃ７ ,-(CH ２ ) ｏ８ S(O) ２ NHR ｃ８ ,-(CH ２ ) ｏ９ NHS (O) ２ R ｃ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－ ６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－ １０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ４－１ and R ４－２ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｐ１ OR ｄ１ ,-(CH ２ ) ｐ２ C(O)R ｄ２ ,-(CH ２ ) ｐ３ NHC(O)R ｄ３ ,-(CH ２ ) ｐ４ C(O)NHR ｄ４ ,-(CH ２ ) ｐ５ NR ｄ５ R ｄ６ ,-(CH ２ ) ｐ６ S(O) ｐ７ R ｄ７ ,-(CH ２ ) ｐ８ S(O) ２ NHR ｄ８ ,-(CH ２ ) ｐ９ NHS (O) ２ R ｄ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１ ０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. Or, R ４－１ and R ４－２ It is connected to C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Forming an aryl group or a 5-10 membered heteroaryl group, the C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group may optionally be further enriched with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ５ These are hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－ ６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｑ１ OR ｅ１ ,-(CH ２ ) ｑ２ C(O)R ｅ２ ,-(CH ２ ) ｑ３ NHC(O)R ｅ３ ,-(CH ２ ) ｑ４ C(O)NHR ｅ４ ,-(CH ２ ) ｑ５ NR ｅ５ R ｅ６ ,-(CH ２ ) ｑ６ S(O) ｑ７ R ｅ７ ,-(CH ２ ) ｑ８ S(O) ２ NHR ｅ８ ,-(CH ２ ) ｑ９ NHS (O) ２ R ｅ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－ ６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－ １０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ６ and R ７ These are, independently, hydrogen and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １ －６ Hydroxyalkyl group, C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１４ Selected from an aryl group or a 5- to 14-membered heteroaryl group, the C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１４ The aryl group or 5-14 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ａ１ , R ａ２ , R ａ３ , R ａ４ , R ａ５ , R ａ６ , R ａ７ , R ａ８ and R ａ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C １－６ alkyl group, C ２－ ６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－ ６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ｂ１ , R ｂ２ , R ｂ３ , R ｂ４ , R ｂ５ , R ｂ６ , R ｂ７ , R ｂ８ and R ｂ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C １－６ alkyl group, C ２－ ６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－ ６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ｃ１ , R ｃ２ , R ｃ３ , R ｃ４ , R ｃ５ , R ｃ６ , R ｃ７ , R ｃ８ and R ｃ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C １－６ alkyl group, C ２－ ６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－ ６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ , R ｄ８ and R ｄ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C １－６ alkyl group, C ２－ ６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－ ６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. R ｅ１ , R ｅ２ , R ｅ３ , R ｅ４ , R ｅ５ , R ｅ６ , R ｅ７ , R ｅ８ and R ｅ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, the amino group, C １－６ alkyl group, C ２－ ６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－ ６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－ ８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. u is 0, 1, 2, 3, 4, or 5. m1, m2, m3, m4, m5, m6, m8, and m9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. n1, n2, n3, n4, n5, n6, n8, and n9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. o1, o2, o3, o4, o5, o6, o8, and o9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. p1, p2, p3, p4, p5, p6, p8, and p9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. q1, q2, q3, q4, q5, q6, q8, and q9 are each independently selected from 0, 1, 2, 3, 4, 5, or 6. m7, n7, o7, p7, and q7 are each independently selected from 0, 1, 2, or 3. r1, r2, and r3 are each independently selected from 0, 1, or 2. The compound according to claim 1, its stereoisomer, or its pharmaceutically acceptable salt, characterized in that x is 0, 1, 2, 3, 4, or 5. [Claim 4] The compound is as shown in formula (VII), 【Transformation 3】 Here, Ring A is C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１４ Selected from an aryl group or a 5- to 14-membered heteroaryl group, R １ These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｍ１ OR ａ１ ,-(CH ２ ) ｍ２ C(O)R ａ２ ,-(CH ２ ) ｍ３ NHC(O)R ａ３ ,-(CH ２ ) ｍ４ C(O)NHR ａ４ ,-(CH ２ ) ｍ５ NR ａ５ R ａ６ ,-(CH ２ ) ｍ６ S(O) ｍ７ R ａ７ ,-(CH ２ ) ｍ８ S(O) ２ NHR ａ８ ,-(CH ２ ) ｍ９ NHS (O) ２ R ａ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １ －６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３ －８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. The compound according to claim 1, its stereoisomer, or its pharmaceutically acceptable salt, characterized in that x is 0, 1, 2, 3, 4, or 5. [Claim 5] The compound is as shown in formula (VII-B), 【Chemistry 4】 Preferably, the compound is as shown in formula (VII-B-1) or (VII-B-2), 【Transformation 5】 More preferably, the compound is as shown in formula (VII-1) or (VII-2), 【Transformation 6】 Here, R ４－１－１ These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １ －６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from an aryl group or a 5- to 10-membered heteroaryl group, w is selected from 0, 1, 2, 3, 4, 5, or 6. More preferably, the compound is of formula (VII-1-1), (VII-1-2), (VII-2-1), or (VII-2-2) 【Transformation 7】 The compound according to feature 4, its stereoisomer, or its pharmaceutically acceptable salt, as shown in [reference]. [Claim 6] Ring A is C ３－８ Cycloalkyl group, 3-10 membered heterocyclyl group, C ６－１０ Selected from an aryl group or a 5- to 10-membered heteroaryl group, Preferably, it is a 5-6 member heterocyclyl group, a 5-6 member heteroaryl group, a 5-6 member heteroaryl group condensed into a 5-6 member heteroaryl group, a 5-6 member heteroaryl group condensed into a phenyl group, or a 5-6 member heteroaryl group condensed into a 5-6 member heterocyclyl group. more, 【Transformation 8】 And, more, 【Chemistry 9】 And, more, 【Chemistry 10】 The compound according to claim 3, its stereoisomer, or its pharmaceutically acceptable salt. [Claim 7] The aforementioned compound is as shown in formula (IV) or formula (IV-A), 【Chemistry 11】 Here, Ring B is C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１４ Selected from an aryl group or a 5- to 14-membered heteroaryl group, or ring B is absent. 【Chemistry 12】 [Chemistry 13] And, R １ These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Aryl group, 5-10 membered heteroaryl group, -(CH ２ ) ｍ１ OR ａ１ ,-(CH ２ ) ｍ２ C(O)R ａ２ ,-(CH ２ ) ｍ３ NHC(O)R ａ３ ,-(CH ２ ) ｍ４ C(O)NHR ａ４ ,-(CH ２ ) ｍ５ NR ａ５ R ａ６ ,-(CH ２ ) ｍ６ S(O) ｍ７ R ａ７ ,-(CH ２ ) ｍ８ S(O) ２ NHR ａ８ ,-(CH ２ ) ｍ９ NHS (O) ２ R ａ９ Selected from, the amino group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １ －６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３ －８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group or 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ They may be substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups. x is 0, 1, 2, 3, 4 or 5, The compound according to claim 1, its stereoisomer, or its pharmaceutically acceptable salt, characterized in that v is 1, 2, 3, or 4. [Claim 8] The aforementioned compounds are as shown in formula (IV-1), formula (IV-2), (IV-A-1), or formula (IV-A-2), 【Chemistry 14】 Preferably, the compound is of formula (IV-1-1), formula (IV-2-1), (IV-A-3), or formula (IV-A-4) 【Chemistry 15】 The compound according to feature 7, its stereoisomer, or its pharmaceutically acceptable salt, as shown in [reference]. [Claim 9] The aforementioned compound is as shown in (I-AAA), 【Chemistry 16】 Here, L ２ These are bonds, -O-, -NH-, -CO-, -CONH-, C １－３ Alkylene group, C ２－４ Alkenylene group, C ２－４ Alkynylene group, -O-C １－３ Alkylene-,-S-C １－３ Alkylene-, -C １－３ Alkylene-NH-,-C １－３ Alkylene-C(O)NH-,-C １－３ Alkylene-NHC(O)-,-C １－３ Alkylene-S(O) ｒ４ -, -C １－３ Alkylene-NHS(O) ｒ５ - or -C １－３ Alkylene-S(O) ｒ６ Selected from NH-, and the aforementioned -NH-, -CONH-, C １－３ Alkylene group, C ２－４ Alkenylene group, C ２－４ Alkynylene group, -O-C １－３ Alkylene-,-S-C １－３ Alkylene-, -C １－３ Alkylene-NH-,-C １－３ Alkylene-C(O)NH-,-C １－３ Alkylene-NHC(O)-,-C １－３ Alkylene-S(O) ｒ４ -, -C １－３ Alkylene-NHS(O) ｒ５ - or -C １－３ Alkylene-S(O) ｒ６ NH- can optionally be hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １ －３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－ ３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６ －１０ Substituted with one or more aryl groups or 5-6 membered heteroaryl groups, Ring E is C ３－１２ Cycloalkyl group, 3-12 member heterocyclyl group, C ６－１０ Selected from aryl groups and 5-10 membered heteroaryl groups, preferably 3-12 membered heterocyclyl groups. R ２－１－１ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF ２ ,=CHF,=NOC １－６ alkyl group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Heteroalkyl groups, C １－６ Deuterated heteroalkyl groups, C １－６ Haloheteroalkyl groups, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from an aryl group or a 5- to 10-membered heteroaryl group, where the C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－ ６ Haloalkoxy group, C １－６ Heteroalkyl groups, C １－６ Deuterated heteroalkyl groups, C １－６ Haloheteroalkyl groups, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, =CF ２ ,=CHF,=NOC １－ ６ alkyl group, C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １－６ Heteroalkyl groups, C １－ ６ Deuterated heteroalkyl groups, C １－６ Haloheteroalkyl groups, C １－６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Substituted with one or more aryl groups and 5- to 10-membered heteroaryl groups, R ２－１－１ Preferably, a methyl group, an ethyl group, a methoxy group, F, =CF ２ ,-CHF ２ ien-CH ２ F, -CF ３ ien-CH ２ CHF ２ ,-CHF ２ CH ３ ien-CH ２ CF ３ ien-CH ２ OCH ３ ien-CH ２ OCD ３ ien-CH ２ OCF ３ ien-CH ２ O-cyclopropyl group, -CH ２ SCF ３ Cyclopropyl group, cyclobutyl group, OCD ３ or OCF ３ And, j is 0, 1, 2, 3, 4, or 5. r4, r5, and r6 are each independently selected from 0, 1, or 2. The compound according to claim 1, its stereoisomer, or its pharmaceutically acceptable salt, characterized in that v is 1, 2, 3, or 4. [Claim 10] The aforementioned compound is as shown in (I-AAA-1) or (I-AAA-2), 【Chemistry 17】 The compound according to claim 9, its stereoisomer, or its pharmaceutically acceptable salt, characterized in that v is 1, 2, 3, or 4. [Claim 11] The aforementioned compound is as shown in (I-AA-1) or (I-AA-2), [Chemistry 18] Here, R ４－１－１ These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－６ alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Deuterated alkyl groups, C １－６ Haloalkyl group, C １－６ Alkoxy group, C １－６ Deuterated alkoxy group, C １－６ Haloalkoxy group, C １ －６ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from an aryl group or a 5- to 10-membered heteroaryl group, The compound according to claim 1, its stereoisomer, or its pharmaceutically acceptable salt, characterized in that w is selected from 0, 1, 2, 3, 4, 5, or 6. [Claim 12] Ring B is C ３－６ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Selected from an aryl group or a 5- to 10-membered heteroaryl group, or ring B is absent. Preferably, ring B is C ３－６ Selected from a cycloalkyl group, a phenyl group, or a 5-6 membered heteroaryl group, or ring B is absent. More preferably, ring B is 【Chemistry 19】 Selected from, or ring B does not exist, More preferably, ring B is 【Chemistry 20】 Selected from, and more preferably, ring B is 【Chemistry 21】 A compound according to claim 1, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, selected from the above. [Claim 13] The aforementioned compounds are as shown in (I-AA), (I-AA-3), or (I-AA-4), 【Chemistry 22】 The compound according to claim 1, its stereoisomer, or its pharmaceutically acceptable salt, characterized in that v is 1, 2, 3, or 4. [Claim 14] L １ is a bond, O or -CF ２ - Selected from, more preferably L １ is selected from the combinations, and more preferably L １ is selected from O, and more preferably L １ is bonded or -CF ２ - Selected from, and / or R １ These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Aryl group, 5-6 membered heteroaryl group, -(CH ２ ) ｍ１ OR ａ１ ,-(CH ２ ) ｍ２ C(O)R ａ２ ,-(CH ２ ) ｍ３ NHC(O)R ａ３ ,-(CH ２ ) ｍ４ C(O)NHR ａ４ ,-(CH ２ ) ｍ５ NR ａ５ R ａ６ ,-(CH ２ ) ｍ６ S(O) ｍ７ R ａ７ ,-(CH ２ ) ｍ８ S(O) ２ NHR ａ８ ,-(CH ２ ) ｍ９ NHS (O) ２ R ａ９ Selected from, the amino group, C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－ ３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－ ６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ It may be substituted with one or more of aryl groups and 5- to 6-membered heteroaryl groups. R ａ１ , R ａ２ , R ａ３ , R ａ４ , R ａ５ , R ａ６ , R ａ７ , R ａ８ and R ａ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ It may be substituted with one or more of aryl groups and 5- to 6-membered heteroaryl groups. Preferably, R １ These are hydrogen, deuterium, oxo group, trifluoromethyl group, fluorine, chlorine, bromine, and -CH ２ CF ３ cyano group, methoxy group, -CH=CF ２ ien-CH ２ CHF ２ And, Preferably, R １ It consists of hydrogen, deuterium, oxo group, trifluoromethyl group, fluorine, and -CH ２ CF ３ cyano group, methoxy group, -CH=CF ２ ien-CH ２ CHF ２ And, More specifically, R １ It consists of an oxo group, a trifluoromethyl group, fluorine, and -CH ２ CF ３ , it is a cyano group, and / or R ２－１ and R ２－２ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Aryl group, 5-6 membered heteroaryl group, -(CH ２ ) ｎ１ OR ｂ１ ,-(CH ２ ) ｎ２ C(O)R ｂ２ ,-(CH ２ ) ｎ３ NHC(O)R ｂ３ ,-(CH ２ ) ｎ４ C(O)NHR ｂ４ ,-(CH ２ ) ｎ５ NR ｂ５ R ｂ６ ,-(CH ２ ) ｎ６ S(O) ｎ７ R ｂ７ ,-(CH ２ ) ｎ８ S(O) ２ NHR ｂ８ ,-(CH ２ ) ｎ９ NHS (O) ２ R ｂ９ Selected from, the amino group, C １－３ alkyl group, C ２－４ Alkenyl group, C ２ －４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The C may be substituted with one or more of an aryl group and a 5-6 membered heteroaryl group. ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The aryl group and the 5-6 membered heteroaryl group substituents may optionally further include hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, carboxyl group, oxo group, thio group, and C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Substituted with one or more aryl groups and 5-6 membered heteroaryl groups, Preferably, R ２－１ and R ２－２ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－ ３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Aryl group, 5-6 membered heteroaryl group, -(CH ２ ) ｎ １ OR ｂ１ ,-(CH ２ ) ｎ２ C(O)R ｂ２ ,-(CH ２ ) ｎ３ NHC(O)R ｂ３ ,-(CH ２ ) ｎ４ C(O)NHR ｂ４ ,-(CH ２ ) ｎ５ NR ｂ５ R ｂ６ ,-(CH ２ ) ｎ６ S(O) ｎ７ R ｂ７ ,-(CH ２ ) ｎ８ S(O) ２ NHR ｂ８ ,-(CH ２ ) ｎ９ NHS (O) ２ R ｂ９ Selected from, the amino group, C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ It may be substituted with one or more of aryl groups and 5- to 6-membered heteroaryl groups. Or, R ２－１ and R ２－２ It is connected to C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Forming an aryl group or a 5-10 membered heteroaryl group, the C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group may optionally be further enriched with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ It may be substituted with one or more of aryl groups and 5- to 6-membered heteroaryl groups. R ｂ１ , R ｂ２ , R ｂ３ , R ｂ４ , R ｂ５ , R ｂ６ , R ｂ７ , R ｂ８ and R ｂ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ It may be substituted with one or more of aryl groups and 5- to 6-membered heteroaryl groups. Preferably, R ２－１ teeth, 【Chemistry 23】 Selected from, preferably, ring E is 【Chemistry 24】 Here, ring E' is selected from 3- to 12-membered heterocyclyl groups, preferably a 3- to 8-membered monocyclic heterocyclyl group, a 3- to 8-membered fused heterocyclyl group, a 3- to 8-membered bridged heterocyclyl group, or a 3- to 8-membered spiro-ring heterocyclyl group, more preferably a 3- to 8-membered monocyclic heterocyclyl group, a 3- to 8-membered fused heterocyclyl group, or a 3- to 8-membered spiro-ring heterocyclyl group, more preferably a 5- to 9-membered heterocyclyl group, more preferably a 5- to 6-membered heterocyclyl group, and preferably ring E' is 【Chemistry 25】 Selected from, Preferably, L ２ CH ２ And, Preferably, R ２－１ is hydrogen, methyl group, 【Chemistry 26】 Cyclopropyl group, -CH=CF ２ ien-CH ２ -Cyclopropyl group, -OCH ２ OCD ３ ien-CH ２ OCD ３ ien-CH ２ OCHF ２ ien-CH ２ COOCH ２ CH ３ ien-CH ２ COOH, -CH ２ CH ２ COOH, 【Chemistry 27】 Selected from, Preferably, R ２－２ is selected from hydrogen or a methyl group, preferably R ２－２ It is selected from hydrogen, and / or R ４－１ and R ４－２ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Aryl group, 5-6 membered heteroaryl group, -(CH ２ ) ｐ１ OR ｄ１ ,-(CH ２ ) ｐ２ C(O)R ｄ２ ,-(CH ２ ) ｐ３ NHC(O)R ｄ３ ,-(CH ２ ) ｐ４ C(O)NHR ｄ４ ,-(CH ２ ) ｐ５ NR ｄ５ R ｄ６ ,-(CH ２ ) ｐ６ S(O) ｐ７ R ｄ７ ,-(CH ２ ) ｐ８ S(O) ２ NHR ｄ８ ,-(CH ２ ) ｐ９ NHS (O) ２ R ｄ９ Selected from, the amino group, C １－３ alkyl group, C ２－４ Alkenyl group, C ２ －４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－８ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １ －３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ It may be substituted with one or more of aryl groups and 5- to 6-membered heteroaryl groups. Or, R ４－１ and R ４－２ It is connected to C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ Forming an aryl group or a 5-10 membered heteroaryl group, the C ３－８ Cycloalkyl group, 3-8 membered heterocyclyl group, C ６－１０ The aryl group and the 5-10 membered heteroaryl group may optionally be further enriched with hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ It may be substituted with one or more of aryl groups and 5- to 6-membered heteroaryl groups. R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ , R ｄ８ and R ｄ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ It may be substituted with one or more of aryl groups and 5- to 6-membered heteroaryl groups. Preferably, R ４－１ teeth, 【Chemistry 28】 Selected from, preferably R ４－１ teeth, 【Chemistry 29】 Selected from, preferably R ４－１ teeth, 【Transformation 30】 Selected from, More specifically, R ４－１ teeth, 【Chemistry 31】 Selected from, more preferably R ４－１ teeth, 【Chemistry 32】 Selected from, more preferably R ４－１ teeth, 【Transformation 33】 Selected from, more preferably R ４－１ teeth, 【Transformation 34】 Selected from, more preferably R ４－１ teeth, 【Chemistry 35】 Selected from, More specifically, R ４－２ It is selected from hydrogen, and / or R ５ These are hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－ ３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Aryl group, 5-6 membered heteroaryl group, -(CH ２ ) ｑ１ OR ｅ１ ,-(CH ２ ) ｑ２ C(O)R ｅ２ ,-(CH ２ ) ｑ３ NHC(O)R ｅ３ ,-(CH ２ ) ｑ４ C(O)NHR ｅ４ ,-(CH ２ ) ｑ５ NR ｅ５ R ｅ６ ,-(CH ２ ) ｑ６ S(O) ｑ７ R ｅ７ ,-(CH ２ ) ｑ８ S(O) ２ NHR ｅ８ ,-(CH ２ ) ｑ９ NHS (O) ２ R ｅ９ Selected from, the amino group, C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２ －４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ It may be substituted with one or more of aryl groups and 5- to 6-membered heteroaryl groups. R ｅ１ , R ｅ２ , R ｅ３ , R ｅ４ , R ｅ５ , R ｅ６ , R ｅ７ , R ｅ８ and R ｅ９ These are, independently, hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-6 membered heteroaryl groups, the amino group, C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ The aryl group or 5-6 membered heteroaryl group may optionally be further a hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, or C １－３ alkyl group, C ２－４ Alkenyl group, C ２－４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ It may be substituted with one or more of aryl groups and 5- to 6-membered heteroaryl groups. Preferably, R ５ These are hydrogen, fluorine, methyl group, isopropyl group, 【Transformation 36】 Trifluoromethyl group, monofluoromethyl group, cyano group, cyclopropyl group, ethyl group, deuterated ethyl group, cyclobutyl group, cyclopentyl group, cyclohexyl group, 【Chemistry 37】 Selected from, Preferably, R ５ These are hydrogen, fluorine, methyl group, isopropyl group, 【Transformation 38】 Selected from trifluoromethyl group, monofluoromethyl group, cyano group, cyclopropyl group, and ethyl group, More specifically, R ５ These are hydrogen, fluorine, methyl group, isopropyl group, 【Chemistry 39】 Selected from trifluoromethyl group, monofluoromethyl group, and cyano group, and / or R ４－１－１ These are independently hydrogen, deuterium, halogen, amino group, hydroxyl group, cyano group, nitro group, oxo group, thio group, and C １－３ alkyl group, C ２－４ Alkenyl group, C ２ －４ Alkynyl group, C １－３ Deuterated alkyl groups, C １－３ Haloalkyl group, C １－３ Alkoxy group, C １－３ Deuterated alkoxy group, C １－３ Haloalkoxy group, C １－３ Hydroxyalkyl group, C ３－６ Cycloalkyl group, 3-6 membered heterocyclyl group, C ６－１０ Selected from aryl groups and 5-6 membered heteroaryl groups, Preferably, R ４－１－１ The compound according to claim 1, its stereoisomer, or its pharmaceutically acceptable salt, characterized in that the group is independently selected from hydrogen, fluorine, and a methyl group. [Claim 15] The aforementioned compound, 【Chemistry 40】 【Chemistry 41】 【Chemistry 42】 【Chemistry 43】 【Chemistry 44】 【Chemistry 45】 【Chemistry 46】 【Chemistry 47】 【Chemistry 48】 【Chemistry 49】 [Transformation 50] 【Chemistry 51】 【Chemistry 52】 【Chemistry 53】 【Chemistry 54】 【Transformation 55】 【Transformation 56】 【Chemistry 57】 【Chemistry 58】 【Chemistry 59】 【Transformation 60】 【Chemistry 61】 【Transformation 62】 【Transformation 63】 【Chemistry 64】 【Transformation 65】 【Chemical Formula 66】 【Transformation 67】 【Transformation 68】 【Transformation 69】 【Transformation 70】 The compound according to claim 1, its stereoisomer, or its pharmaceutically acceptable salt, as shown in [reference]. [Claim 16] A compound represented by the following general formula, its stereoisomer, or a pharmaceutically acceptable salt thereof, 【Chemistry 71】 Ring A, R １ , R ２－１ , R ２－２ , R ４－１ , R ４－２ , R ６ , R ７ , x and M １ The definition of is as described in claim 3, a compound, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. [Claim 17] The aforementioned compound, 【Chemistry 72】 【Transformation 73】 【Chemistry 74】 【Chemistry 75】 A compound according to claim 16, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, selected from the above. [Claim 18] A method for producing a compound shown in formula (I-A-1), its stereoisomer, or a pharmaceutically acceptable salt thereof, wherein the compound shown in formula (INT-3) and formula (INT-2) is reacted to produce the compound shown in formula (I-A-1), 【Transformation 76】 Preferably, the reaction is carried out in the presence of a base and a catalyst, wherein the base is an organic base and the catalyst is an amide condenser. Ring A, R １ , R ２－１ , R ２－２ , R ４－１ , R ４－２ , R ６ , R ７ , x and M １ A manufacturing method characterized in that the definition of is as described in claim 3. [Claim 19] A pharmaceutical composition comprising a therapeutically effective amount of a compound according to any one of claims 1 to 15, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, diluents, or excipients. [Claim 20] The pharmaceutical composition according to claim 19 for use as an IL-17 inhibitor drug. [Claim 21] A pharmaceutical composition for use in the treatment of an autoimmune disease, wherein the autoimmune disease is preferably selected from psoriasis, plaque psoriasis, guttate psoriasis, reverse psoriasis, pustular psoriasis, erythrodermic psoriasis, psoriatic arthritis, ankylosing spondylitis, hidradenitis suppurativa, rheumatoid arthritis, palmoplantar psoriasis, spondyloarthritis, and noninfectious uveitis, according to claim 19.

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