Device for measuring biosecreted substances

Abstract

The present invention relates to a device for measuring biologically secreted substances, the device comprising an adsorption membrane, an electrode detection assembly, a capacitance-to-digital conversion circuit (CDC), and a processing module, wherein the adsorption membrane is used to adsorb biologically secreted substances, the capacitance-to-digital conversion circuit is coupled to the electrode detection assembly and is used by the electrode detection assembly to obtain the mutual capacitance when secreted substances are present on the adsorption membrane, and the processing module is coupled to the capacitance-to-digital conversion circuit and is used to obtain the mutual capacitance when secreted substances are not present on the adsorption membrane and to output a signal of the content of substances secreted from the biological body based on the two obtained mutual capacitances.

Description

[Technical Field]

[0001] This invention relates to the measurement of secreted substances in living organisms, and more particularly to the measurement of the oil content secreted from human skin. [Background technology]

[0002] Conventional methods for detecting skin oils often combine thin-film measurement and optical measurement, where oils are absorbed by a thin film and then compared with a standard substance using an optical method. For example, U.S. Patent No. 4,532,937 discloses attaching a microporous film to the skin to absorb sebum, and U.S. Patent No. 5,119,828 discloses using a microporous hydrophobic polymer film, where the film becomes opaque when the pores are filled with a gaseous material, but becomes semi-transparent when the pores are filled with sebum, and optical measurements are performed using these properties. Alternatively, German Patent DE29700324U1 discloses performing skin analysis and evaluation using a test film.

[0003] Currently, the most widely used device for detecting skin oils in cosmetic or medical applications is the CK device. This CK device also employs a combination of oil-absorbing paper and photoelectric technology. Each time it is used, the detection end must first be inserted into another component for calibration (the oil measuring device is divided into two parts), then the detection end must be in contact with the area to be measured for 30 seconds, and then inserted into the other component again for measurement. This makes the operation complex, inefficient, and indirectly reflects the skin's oil content through light transmittance.

[0004] The actual unit of measurement for the oil content of the epidermis is micrograms (ug / cm²) per square centimeter. 2 The CK device employs a method of calculating the oil content based on the light transmittance of the oil absorbent paper, ranging from 50 to 350 ug / cm³. 2 It possesses a certain level of discriminatory ability only within a certain range, and generally classifies different areas of human body into three levels: "low oil," "normal," and "high oil." The corresponding table is as follows. JPEG2026517517000002.jpg40170

[0005] Both the properties of the oil-absorbing paper material itself and the area over which oil spreads on the paper affect the light transmittance. Because there are relatively many influencing factors in the intermediate process, the requirements for oil-absorbing paper (consumables) are relatively high, and it is necessary to use specified oil-absorbing paper. Therefore, measurement methods combining thin film and optical techniques, whether using conventional technology or a CK (Compact Energy Collection) system, cannot accurately establish a correspondence with oil content, resulting in a relatively large range of uncertainty, and theoretically, there is little room for improvement in accuracy. [Overview of the project] [Problems that the invention aims to solve]

[0006] To improve upon the shortcomings of conventional technology, the present invention provides a device for measuring biologically secreted substances. [Means for solving the problem]

[0007] The biological secretion measuring device according to the present invention comprises an adsorption membrane, an electrode detection assembly, a capacitance-to-digital conversion circuit (CDC), and a processing module. The adsorption membrane is used to adsorb biological secretions; the capacitance-to-digital conversion circuit is coupled to the electrode detection assembly and is used by the electrode detection assembly to obtain the mutual capacitance when secretions are present on the adsorption membrane; and the processing module is coupled to the capacitance-to-digital conversion circuit and is used to obtain the mutual capacitance when secretions are not present on the adsorption membrane and to output a signal indicating the content of the substance secreted from the biological body based on the two obtained mutual capacitances.

[0008] The measuring device of the present invention can measure the content of various substances secreted from living organisms by mutual capacitance. Taking the case of measuring oils secreted from the skin as an example, in this case, oil-absorbing paper is selected as the adsorption membrane, and the change in the difference in mutual capacitance when oils are present or absent on the oil-absorbing paper is directly detected. Such an incremental change directly caused by the amount of oil basically excludes the material elements of the oil-absorbing paper itself and is directly related only to the amount of oil. In oils secreted from the surface of living organisms, especially from the human face, the main components are triglycerides, fatty acids, phospholipids, inositol, esterified cholesterol, etc. The overall dielectric constant of most oils is 3.04 to 3.2, while the dielectric constant of PP, the main component of oil-absorbing paper, is 2.3 to 2.6. According to the capacitance formula C = εS / d, it is known that capacitance is directly proportional to dielectric constant, and it is known that the dielectric constant of oils is basically about 30% greater than that of oil-absorbing paper. As a result, the effect of the change in capacitance increment becomes more pronounced, and therefore, the oil content on the oil-absorbing paper can be detected more accurately. Furthermore, by combining it with a capacitance-to-digital converter (CDC), such as DAI7142 or ADI7147, and using a Δ-Σ modulation scheme to charge and discharge the measured capacitance multiple times and compare it with a reference capacitance (see US Patent Number: 5,134,401), the measured capacitance value can be directly converted to a digital value, thereby increasing the measurement sensitivity of the capacitance to 1ff level.

[0009] The measuring device of the present invention can immediately provide a comprehensive feedback of the skin's oil content after the detection end has been in contact with the area to be measured for a certain period of time. The device is simple, integrated, and low-cost.

[0010] Regarding the mutual capacitance when secreted substances are present or absent on the adsorption membrane, there are three methods, classified from longest to shortest based on the time interval between which the two mutual capacitances were acquired: (1) pre-calibration, (2) time-resolved detection, and (3) simultaneous detection. The longer the time interval, the greater the difference in the measurement environment, resulting in a decrease in accuracy.

[0011] In the pre-calibration scheme, the hardware configuration of the measuring device further includes a measuring surface configured to indirectly contact a living organism via an adsorption membrane, the electrode detection assembly is configured to include at least two first electrodes provided on the measuring surface, the adsorption membrane is set on the measuring surface during measurement and is located within a mutual capacitance detection space formed between the first electrodes, a capacitance-to-digital conversion circuit is coupled to each first electrode and used to acquire a first mutual capacitance between the first electrodes, and a processing module is coupled to the capacitance-to-digital conversion circuit. According to the above hardware structure, mutual capacitance data when no secreted substances are present on the adsorption membrane can be detected in advance, and the results can be stored as reference data in the processing module's memory for use. During detection, the first electrode acquires the first mutual capacitance after the adsorption membrane has adsorbed the secreted substances. Based on the reference data and the first mutual capacitance after the adsorption membrane has adsorbed the secreted substances, the processing module outputs a signal indicating the content of the substance secreted from the living organism. For example, the reference data reflects the dielectric constant of the pure adsorption membrane, and the mutual capacitance after the adsorption membrane has adsorbed the secreted substances reflects the dielectric constants of the adsorption membrane and the secreted substances. By using the difference between the two, the secreted substances can be identified and their content can be detected by capacitance. In the pre-calibration scheme, the time interval between acquiring the two mutual capacitances is relatively long, so interference due to differences in environmental changes is relatively large.

[0012] In the time-division detection scheme, the process is similarly carried out depending on the hardware structure described above. Based on this foundation, during detection, first, a human-machine interaction, such as clicking a button, causes the device to perform a blank measurement of the first mutual capacitance of the adsorbent membrane when it is not adsorbing secretions placed on the measurement surface. Next, after the adsorbent membrane is in contact with the surface of the living organism for a certain period of time, the button is clicked again to measure the first mutual capacitance after the adsorbent membrane has adsorbed the secreted substance. The processing module outputs a signal indicating the content of the substance secreted from the living organism based on the first mutual capacitance before and after the adsorbent membrane adsorbs the secreted substance. In this scheme, because the time interval between acquiring the two mutual capacitances is relatively short (in seconds), interference due to environmental changes is relatively low. At the same time, for example, common-mode interference of the environment (mutual capacitance C after adsorption) can be detected from the difference between the two mutual capacitances. aw 2+C環境コモンモード干渉 - Mutual capacitance C before adsorption aw 1+C 環境コモンモード干渉 Subtract ) to obtain a more accurate detection result.

[0013] In the simultaneous detection scheme, based on the above hardware structure, it is also necessary to provide a non-measurement surface to prevent the adsorption membrane from coming into contact with the living body during measurement. The electrode detection assembly is configured to further include at least two second electrodes provided on the non-measurement surface, the adsorption membrane is set synchronously with the non-measurement surface during measurement and is located within a mutual capacitance detection space formed between the second electrodes, and a capacitance-to-digital conversion circuit is coupled to each second electrode and used to acquire the second mutual capacitance between the second electrodes. In the above hardware structure, at the time of detection, the second mutual capacitance is defined as the mutual capacitance when no secreted substance is present on the adsorption membrane, and the first mutual capacitance after the adsorption membrane has adsorbed the secreted substance is defined as the mutual capacitance when the secreted substance is present on the adsorption membrane. The processing module outputs a signal indicating the content of the substance secreted from the living body based on the second mutual capacitance and the first mutual capacitance after the adsorption membrane has adsorbed the secreted substance. In this scheme, the acquisition intervals for the two capacitances reach a level where they are almost simultaneous (at the millisecond level, depending on the sampling interval of the chip), essentially eliminating interference due to environmental changes. At the same time, errors due to common-mode environmental interference can be removed by differential calculation, thereby obtaining more accurate detection results. Since simultaneous detection is performed in two separate regions, the electrodes (first electrode, second electrode) in the two regions can be set to match in order to avoid electrode-specific interference due to differences after differential calculation (if the shape and size of the electrodes are different, a difference will occur in the electric field of their mutual capacitance, and the acquired mutual capacitance will also be different even for the same substance). However, in practice, due to manufacturing process problems, it is basically impossible to achieve theoretical matching, and for this reason, the content signal can be corrected based on the second mutual capacitance. Specifically, the correction method further includes obtaining a first difference between a first mutual capacity and a second mutual capacity before the adsorption membrane adsorbs the secreted substance, obtaining a second difference between the first mutual capacity and the second mutual capacity after the adsorption membrane adsorbs the secreted substance, and the processing module outputting a signal of the content of the substance secreted from the organism based on the difference between the first difference and the second difference.Before the adsorption membrane adsorbs the secreted substance, neither adsorption membrane contains the secreted substance, and the first difference after subtraction reflects the electrode-specific interference. However, after the adsorption membrane adsorbs the secreted substance, if the secreted substance is present on one of the two adsorption membranes in the two regions but not on the other, the second difference after subtraction reflects the dielectric constant of the secreted substance and the electrode-specific interference. Furthermore, by subtracting the first and second differences, the electrode-specific interference can be eliminated, and the dielectric constant of the secreted substance can be obtained and detected. In this scheme, it is not necessary to ensure that the electrodes in the two regions must always coincide, and the requirements for the manufacturing precision of the electrodes are not stringent, thus reducing manufacturing costs.

[0014] As an improvement, an insulating layer may be installed on the surface of each electrode, thereby reducing interference with capacitance and protecting the electrodes from corrosion caused by secreted substances.

[0015] Since whether the adsorbent film adheres to each surface being measured has a relatively large impact on the detection of the dielectric constant, as an alternative improvement, the measuring device may be equipped with a tensioning device to pull the adsorbent film to adhere to the corresponding surface during measurement. Furthermore, the tensioning device may be configured to include a fixing assembly and a rotating shaft knob provided on both sides of each measuring surface, the fixing assembly fixing one end of the adsorbent film, the other end of the adsorbent film passing through the shaft hole of the rotating shaft knob, and when the rotating shaft is rotated, the knurling on the side wall of the rotating shaft rotates, thereby pulling the film tightly and achieving tension, the fixing assembly is configured as a single-end spring compression fixing assembly, and the ease of operation of the single-end spring compression fixing assembly allows the adsorbent film to be removed by applying force to the pressing handle and tightened by releasing the pressing handle. During use, the adsorption film is inserted through the inlet, one end of the film is fixed with a spring compression fixing assembly, the other end of the film is rotated around the electrode detection elastic assembly, the other end of the film is inserted through the inlet, passes through the shaft hole of the rotating shaft knob, and the rotating shaft is rotated to increase the frictional force between the knurling on the side wall of the rotating shaft and the adsorption film, thereby firmly pulling the end of the adsorption film. This operation is continued until the electrode detection elastic assembly is pushed down to the bottom of the stopper, after which the retaining pin is pushed into the internal tooth groove to fix it, thereby ensuring that the electrode detection assembly applies a constant pressing force to the adsorption film due to the spring's repulsive force, causing the film to be pulled.

[0016] As another improvement, a capacitance-to-digital conversion circuit can be installed, allowing the electrode detection assembly to acquire self-capacitance. This self-capacitance reflects the distance between the adsorbent film and the measurement surface, and can also reflect the looseness. In this case, the processing module can output a logical signal indicating that the adsorbent film has been separated from the biological tissue based on the self-capacitance (compared to a threshold), and / or, the processing module can correct the acquired mutual capacitance based on the self-capacitance, thereby avoiding interference due to differences in looseness.

[0017] As another improvement, in the electrode detection assembly, the distance between the electrodes (for example, between the first electrodes) for detecting the mutual capacitance is configured to be between 0.05 and 0.5 mm. The purpose is to control the height of the electric field of the mutual capacitance so that when the adsorption film is placed on the measurement surface, the electric field lines just pass through the adsorption film but do not protrude from its top surface, so that the detection can obtain only the dielectric constant of the substance in the adsorption film, avoid the introduction of the dielectric constant of air due to the protruding part, and improve the detection accuracy.

Brief Description of the Drawings

[0018] [Figure 1] It is a front view showing a measuring device for biological secretion substances. [Figure 2] It is a cross-sectional view showing a measuring device for biological secretion substances. [Figure 3] It is a cross-sectional view showing an electrode assembly. [Figure 4] It is a cross-sectional view showing a rotating shaft tension assembly and a spring compression assembly. [Figure 5] It is a schematic diagram showing the distribution of detection electrodes. [Figure 6] It is a schematic diagram showing the laminated structure of a detection electrode and an adsorption film.

Embodiments of the Invention

[0019] Hereinafter, referring to the drawings of the embodiments of the present invention, the technical solutions of the embodiments of the present invention will be clearly and completely described.

[0020] As shown in Figures 1, 2, 3, 4, and 5, the biosecreting substance measuring device comprises a lower cover 100, an adsorption membrane 140, an electrode detection assembly 110, a rotating shaft tension assembly 120, a spring compression assembly 130, an upper cover 150, and a tightening bolt 160. The electrode detection assembly includes a plug 111, an FPCA circuit assembly 112, a guide bolt 113, a spring 114, a cover bracket 115, a plastic bolt 116, a PFBA circuit assembly 117, and a circuit protection cover 118. The guide bolt 113 passes through the plug 111 and the spring 114 and is screw-fitted and tightened to the lower cover 100, and is restricted by the fitting of the plug 111 with the rib grooves 0-5 of the lower cover 100 to prevent bias. One end of the FPCA circuit assembly 112 is attached to the side of the plug 111, and electrodes 1-1 and 1 -2 are bent and attached to the top and side surfaces of the plug 111 to prevent the FPC soft board from lifting due to bending stress, and ears extend from the ends of the electrodes, and plastic bolts 116 pass through the ears at the ends of the electrodes and are screwed into the plug 111 and tightened, the other end of the FPCA circuit assembly is welded to the PCBA short-circuit assembly 117 and positioned by via posts 1-3 and assembled inside the case of the lower cover 100, and further the circuit protection cover 118 and the plug 111 are fitted and tightened with buckles 1-4. The spring compression assembly 130 includes a guide bolt 131, a pressing piece 132, a spring 133, and a gear block 134. The spring 133 is placed in the spring groove 3-1 of the gear block 134, and the gear block 134 with the spring 133 assembled and the lower cover 100 are assembled at gear 0-4 to make them tightly fitted together. At this time, the guide bolt 131 passes through the side holes 0-6 of the pressing piece 132 and the lower cover 100 and is screw-fitted into the gear block 134 and tightened.The rotating shaft tension assembly 120 includes a stop pin 121 and a rotating shaft 122. The rotating shaft 122 is assembled at the hole positions 0-7 of the lower cover 100. The upper cover 150 is positioned and assembled on the lower cover 100 by via posts 1-3. At the same time, the tip of the rotating shaft 122 passes through the stopper hole 2-5 of the upper cover 150, and the stop pin 121 passes through the guide groove 2-4 and is inserted into the side hole at the top of the rotating shaft 122. At this time, the upper cover and the lower cover are fixed and tightened with tightening bolts 160.

[0021] In test preparation, the adsorption film 140 is inserted from the inlet 0-1, and one end of the adsorption film 140 is fixed by the spring compression assembly 130. The other end of the adsorption film 140 is wound around the electrode detection assembly 110, inserted from the inlet 0-2, passes through the shaft hole 2-1 of the rotating shaft 122, and the rotating shaft 122 is rotated by rotating the stop pin 121. By increasing the frictional force between the knurling 2-2 on the side wall of the rotating shaft and the adsorption film 140, the adsorption film 140 is pulled. After continuing this operation until the electrode detection assembly 110 is pressed down to the bottom of the stopper 0-3, the stop pin 121 is pushed into the internal tooth groove 2-3 and fixed. Thereby, it is ensured that the electrode detection assembly 110 applies a certain pressing force to the adsorption film 140 by the elastic force of the spring 114 to maintain the adsorption film 140 in a standard tension state.

[0022] As shown in FIG. 5, the electrode detection assembly 110 includes a first electrode group 1-1 and a second electrode group 1-2. Each electrode group is composed of two comb-shaped electrodes intersecting with each other. The outer shapes of both electrode groups are the same. The first electrode group includes electrodes C a1 , C a2 and is configured as a first mutual capacitance C aw . The second electrode group includes electrodes C b1 , C b2 and is configured as a second mutual capacitance C bw .

[0023] As shown in Figures 5 and 6, the first electrode group 1-1 comes into contact with the living body to adsorb secreted substances, while the second electrode group 1-2, as a reference for comparison with the first electrode group 1-1, does not come into contact with the living body, and a single insulating film is coated on the surface of the electrodes. The line width of the electrodes themselves and the spacing between the electrodes are both maintained within the range of 0.05 to 0.5 mm. This ensures that the electric field of the mutual capacitance covers adsorption films 140 of various types and thicknesses, but does not exceed the outer surface of the adsorption film. The mutual capacitance when secreted substances are present on the adsorption film 140 and when they are not is determined by three methods, classified from far to near, based on the time intervals between which the two mutual capacitances were obtained. The operating sequence is as follows.

[0024] In the pre-calibration measurement method, it is set that the adsorption membrane 140 is currently not adsorbing any biological secretions, and at this time, the test is started, and the mutual capacity value C of the first set is measured. aW Obtain 1, and the first set of test mutual capacity C aW Set 1 as the reference data, then bring the living organism close to the first electrode group 1-1 and bring it into contact. At this time, the surface adsorption film 140 fuses with and absorbs the biological secretion substance. After the set contact time ends, separate from the organism. At this time, the adsorption film 140 has already absorbed the biological secretion substance, and the test is performed again to obtain the mutual capacity value C of the second set. aw Obtain 2, C aw 2 and C aW The difference from 1 is taken as the volume value result of the secreted substance in the adsorption membrane, and then when replacing it with a standard adsorption membrane of the same type 140, in both cases, the volume value before the secreted substance is adsorbed is not obtained by performing the test, and the first set of test volume data C aw Only 1 will be used as the reference value for comparison.

[0025] In the time-resolved detection method, the adsorption membrane 140 is set to be in a state where it is not currently adsorbing any biological secretions. At this time, the test is started, and the mutual volume value C of the first set is measured. aW Obtain 1, then bring the living organism close to the first electrode group 1-1 and bring it into contact. At this time, the surface adsorption film 140 fuses with and absorbs the biological secretion substance. After the set contact time has ended, separate the organism. At this time, the adsorption film 140 has already absorbed the biological secretion substance, and the test is performed again to obtain the mutual capacity value C of the second set. awObtain 2, C aw 2 and C aW The difference from 1 is taken as the volume value of the secreted substance in the adsorption membrane, and when replacing the adsorption membrane 140 thereafter, the above operating steps should be performed in the same manner.

[0026] In the simultaneous detection method, the adsorption membrane 140 is set to be in a state where it is not currently adsorbing any biological secretions. At this time, the living body is brought directly close to the first electrode group 1-1 and brought into contact with it. The surface adsorption membrane 140 fuses with and absorbs the biological secretions. After the set contact time has ended, the body is separated, and the test is performed to obtain the mutual capacity value C of the first set. aW 1, C bW Get 1, C aw 1 and C bW The difference from 1 is taken as the volume value of the secreted substance in the adsorption membrane, and when replacing the adsorption membrane 140 thereafter, the above operating steps should be performed in the same manner.

[0027] Finally, it should be noted that the above embodiments are merely for illustrating the technical solutions of the present invention and do not limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications and equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A device for measuring biologically secreted substances, It comprises an adsorption film, an electrode detection assembly, a capacitive-to-digital conversion circuit, and a processing module. The adsorption membrane is used to adsorb substances secreted by living organisms. The capacitance-to-digital conversion circuit is coupled to the electrode detection assembly and is used by the electrode detection assembly to obtain the mutual capacitance when the secreted substance is present on the adsorption membrane. The processing module is coupled to the capacitance-to-digital conversion circuit and is used to obtain mutual capacitance when the secreted substance is not present on the adsorption membrane, and to output a signal indicating the content of the substance secreted from the living body based on the two obtained mutual capacitances, characterized in that it is used as a measuring device for biologically secreted substances.

2. The measurement surface is further configured to indirectly contact a living organism via the adsorption membrane, The electrode detection assembly is configured to include at least two first electrodes provided on the measuring surface, The adsorption film is set on the measuring surface during measurement and is located within the mutual capacitance detection space formed between the first electrodes. The aforementioned capacitance-to-digital conversion circuit is coupled to each of the first electrodes and is used to obtain the first mutual capacitance between the first electrodes. The apparatus for measuring biologically secreted substances according to claim 1, characterized in that the processing module is coupled to the capacitive-to-digital conversion circuit.

3. The first mutual capacity before the adsorption membrane adsorbs the secreted substance is defined as the mutual capacity when the secreted substance is not present on the adsorption membrane. The first mutual capacity after the adsorption membrane has adsorbed the secreted substance is defined as the mutual capacity when the secreted substance is present on the adsorption membrane. The apparatus for measuring biologically secreted substances according to claim 2, characterized in that the processing module outputs a signal indicating the content of a substance secreted from a living organism based on the first mutual capacitance before and after the adsorption membrane adsorbs the secreted substance.

4. The mutual capacity when no secreted substances are present on the adsorption membrane is detected in advance, and the result is stored as reference data in the processing module's memory. The first mutual capacity after the adsorption membrane has adsorbed the secreted substance is defined as the mutual capacity when the secreted substance is present on the adsorption membrane. The apparatus for measuring biologically secreted substances according to claim 2, characterized in that the processing module outputs a signal indicating the content of a substance secreted from a living organism based on reference data and the first mutual capacity after the adsorption membrane has adsorbed the secreted substance.

5. The aforementioned measuring device for biologically secreted substances is further provided with a non-measuring surface to prevent the adsorption membrane from coming into contact with the living body during measurement. The electrode detection assembly is configured to include at least two second electrodes provided on the non-measuring surface, The adsorption film is set in synchronization with the non-measurement surface during measurement and is located within the mutual capacitance detection space formed between the second electrodes. The apparatus for measuring biological secretions according to claim 2, characterized in that the capacitance-to-digital conversion circuit is coupled to each of the second electrodes and is used to obtain the second mutual capacitance between the second electrodes.

6. The second mutual capacity is defined as the mutual capacity when the secreted substance is not present on the adsorption membrane. The first mutual capacity after the adsorption membrane has adsorbed the secreted substance is defined as the mutual capacity when the secreted substance is present on the adsorption membrane. The apparatus for measuring biologically secreted substances according to claim 5, characterized in that the processing module outputs a signal indicating the content of a substance secreted from a living organism based on a second mutual capacitance and the first mutual capacitance after the adsorption membrane has adsorbed the secreted substance.

7. The apparatus for measuring biosecreted substances according to claim 6, characterized in that the processing module modifies the content signal based on the second mutual capacitance.

8. The aforementioned modification method is: Before the adsorption membrane adsorbs the secreted substance, the first difference between the first mutual capacity and the second mutual capacity is obtained, After the adsorption membrane adsorbs the secreted substance, the second difference between the first mutual capacity and the second mutual capacity is obtained, The apparatus for measuring biologically secreted substances according to claim 7, further comprising the processing module outputting a signal indicating the content of a substance secreted from a living organism based on the difference between a first difference and a second difference.

9. The apparatus for measuring biologically secreted substances according to claim 2 or 5, characterized in that an insulating layer is provided on the surface of each electrode.

10. The apparatus for measuring biologically secreted substances according to claim 2 or 5, further comprising a tensioning device for pulling the adsorption membrane during measurement to bring it into close contact with the corresponding surface.

11. The tensile device includes a fixing assembly and a rotating shaft knob provided on both sides of the measuring surface, wherein the fixing assembly fixes one end of the adsorption membrane, and the other end of the adsorption membrane passes through the shaft hole of the rotating shaft knob, and when the rotating shaft is rotated, it rotates the knurling on the side wall of the rotating shaft, thereby pulling firmly and achieving the tensile effect, as described in claim 10.

12. The apparatus for measuring biologically secreted substances according to claim 11, characterized in that the aforementioned fixing assembly is configured as a single-end spring compression fixing assembly.

13. The aforementioned capacitance-to-digital conversion circuit is further used by the electrode detection assembly to acquire its own capacitance. The apparatus for measuring biologically secreted substances according to claim 1, characterized in that the processing module is used to output a logical signal that the adsorption membrane has separated from the biological body based on its own capacitance, and / or is used to correct the acquired mutual capacitance based on its own capacitance.

14. The apparatus for measuring biologically secreted substances according to claim 1, characterized in that the secreted substance is composed of an oil or fat, and the adsorption membrane is composed of oil-absorbing paper.

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