Combination of estrogen receptor degraders and AKT inhibitors

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A dosing regimen combining Compound A with an Akt inhibitor addresses the challenges of ER-targeting bifunctional compounds by enhancing cancer treatment efficacy and safety, specifically in breast cancer, through daily administration of approximately 200 mg.

JP2026518466APending Publication Date: 2026-06-08ARVINAS OPERATIONS INC

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Patent Information

Authority / Receiving Office: JP · JP
Patent Type: Applications
Current Assignee / Owner: ARVINAS OPERATIONS INC
Filing Date: 2024-05-31
Publication Date: 2026-06-08

Application Information

Patent Timeline

31 May 2024

Application

08 Jun 2026

Publication

JP2026518466A

IPC: A61K31/496; A61K45/00; A61P35/00; A61P35/04; A61P43/00; A61K31/519; A61K31/4155; A61K31/4375; A61K31/444; A61K31/517

CPC: A61K31/496; A61K31/519; A61K31/4155; A61K31/517; A61K31/4375; A61K31/444; A61K45/06; A61P35/04

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Abstract

This specification discloses a method for treating cancer, comprising administering a daily dose (I) of compound A, or a pharmaceutically acceptable salt thereof, to a subject in combination with an Akt inhibitor. [Formula 1] TIFF2026518466000014.tif66162

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