Hydrogel coating formulation

Abstract

A hydrogel coating formulation comprising oat beta-glucan, colloidal oatmeal, a preservative, a carboxylic acid, an initiator, a crosslinking agent, a pH adjuster, and a solvent. A glove coated with at least one coating layer prepared from the above hydrogel coating formulation. A method for preparing the hydrogel coating formulation includes the steps of adding a first pH adjuster and oat beta-glucan to a first solvent, adding a second pH adjuster to a carboxylic acid, adding a second mixture obtained from step (ii), a crosslinking agent, and an initiator to the first mixture obtained from step (i), adding a second solvent to a third mixture obtained from step (iii), and adding colloidal oatmeal and sodium benzoate to a fourth mixture obtained from step (iv). The glove is coated with at least one layer of the hydrogel coating formulation prepared by the above method.

Description

【Technical Field】 【0001】 The present invention relates to a hydrogel coating formulation and a method for producing the same. In particular, the hydrogel coating formulation is used for coating elastomeric articles such as gloves, although not limited thereto. The hydrogel coating formulation of the present invention exhibits desired swelling characteristics, and gloves coated with the hydrogel coating formulation of the present invention improve skin hydration and also contribute to reducing the transepidermal water loss of the user's skin, showing a desirable sweat absorption capacity. 【Background Art】 【0002】 Single-use gloves made from, although not limited thereto, natural rubber and synthetic latex, etc., provide the wearer with the necessary protection from harmful substances, chemicals, allergens and microbial agents. Gloves form an impermeable latex between the external environment and the user's skin for protection purposes, which causes a lack of air circulation in the internal environment between the glove and the user's skin. Prolonged wearing of gloves may cause an increase in sweating of the user's skin, resulting in excessive accumulation of sweat on the surface of the user's skin due to the lack of air circulation. 【0003】 Subsequently, prolonged excessive accumulation of sweat on the surface of the user's skin may lead to skin damage and irritation such as dryness, redness and itching, and may lead to more severe skin disorders such as, although not limited thereto, chronic contact dermatitis and hydration dermatitis. Contact dermatitis is skin irritation caused by direct contact between the skin and the glove film. Hydration dermatitis can be caused by a certain diffusion of sweat from the inner dermis layer to the outermost layer of the skin, the stratum corneum. 【0004】 Similarly, excessive sweat accumulation on the user's skin surface can lead to thickening of the stratum corneum due to widespread swelling of keratinocytes. This condition is known as moist wound. Furthermore, excessive sweat accumulation on the user's skin surface can act as a breeding ground for bacteria and fungi. 【0005】 On the other hand, excessive sweating on the user's skin surface can cause surfactants to seep out of the gloves, potentially leading to contact dermatitis on the user's skin. Both wet dermatitis and contact dermatitis can result in a damaged skin moisture barrier, increased transepidermal water loss (TEWL), dry skin, increased skin inflammation, and penetration of foreign substances into the skin. [Overview of the Initiative] [Problems that the invention aims to solve] 【0006】 Based on the above, a method for identifying coating formulations has been developed, and in particular, this coating formulation can be used to coat the inner surface of elastomer articles, especially gloves, so that these gloves can exhibit desirable moist properties and sweat absorption capacity, which helps to improve skin moisture retention and reduce transepidermal water loss from the user's skin. [Means for solving the problem] 【0007】 The present invention relates to a hydrogel coating formulation comprising oat beta-glucan, colloidal oatmeal, a preservative, a carboxylic acid, an initiator, a crosslinking agent, a pH adjuster, and a solvent, wherein oat beta-glucan is used in an amount ranging from 0.05% to 0.5% by mass of the hydrogel coating formulation, colloidal oatmeal is used in an amount ranging from 0.05% to 0.5% by mass of the hydrogel coating formulation, a preservative is used in an amount ranging from 0.01% to 0.2% by mass of the hydrogel coating formulation, and a carboxylic acid is used as a hydrogel The present invention relates to a hydrogel coating formulation in which an initiator is used in an amount ranging from 0.1% to 2% by mass of the hydrogel coating formulation, an initiator is used in an amount ranging from 0.01% to 0.12% by mass of the hydrogel coating formulation, a crosslinking agent is used in an amount ranging from 0.0005% to 0.02% by mass of the hydrogel coating formulation, a pH adjusting agent is used in an amount ranging from 0.2% to 1% by mass of the hydrogel coating formulation, and a solvent is used in an amount ranging from 95.66% to 99.58% by mass of the hydrogel coating formulation. The present invention further relates to gloves coated with at least one coating layer prepared from the above hydrogel coating formulation. 【0008】 Furthermore, a method for preparing a hydrogel coating formulation, comprising: (i) adding a first pH adjusting agent and oat beta-glucan to a first solvent while stirring to produce a first mixture, wherein the first mixture is stirred at a speed of 500 rpm to 1000 rpm for 20 to 40 minutes at a temperature in the range of 85°C to 95°C; (ii) adding a second pH adjusting agent to a carboxylic acid while stirring to produce a second mixture, wherein the second mixture is stirred at a speed of 300 rpm to 500 rpm for 5 to 15 minutes at a temperature in the range of 20°C to 30°C; (iii) sequentially adding the second mixture obtained from step (ii), a crosslinking agent, and an initiator to the first mixture obtained from step (i) while stirring to produce a third mixture, wherein the third mixture is A method comprising: (iv) stirring at a speed of 200 rpm to 400 rpm for 160 to 200 minutes at a temperature in the range of 65°C to 75°C; (iv) adding a second solvent to the third mixture obtained from step (iii) while stirring to produce a fourth mixture, wherein the fourth mixture is stirred at a speed of 200 rpm to 400 rpm for 10 to 20 minutes at a temperature in the range of 20°C to 30°C; and (v) sequentially adding colloidal oatmeal and sodium benzoate to the fourth mixture obtained from step (iv) while stirring, in no particular order to produce a hydrogel coating formulation, wherein the hydrogel coating formulation is stirred at a speed of 200 rpm to 400 rpm for 50 to 70 minutes at a temperature in the range of 20°C to 30°C. The gloves are coated with at least one layer of the hydrogel coating formulation prepared by the above method. 【0009】 Additional aspects, features, and advantages of the present invention will become apparent to those skilled in the art, taking into consideration the following detailed description of preferred embodiments of the present invention. [Brief explanation of the drawing] 【0010】 [Figure 1] Swelling rate of the control non-hydrogel coated formulation and the hydrogel coated formulation of the present invention [Figure 2] Sweat absorption capacity of the control glove and the glove of the present invention [Modes for carrying out the invention] 【0011】 A detailed description of preferred embodiments of the present invention is disclosed herein. However, it should be understood that these embodiments are merely illustrative of the present invention and can be embodied in various ways. Accordingly, the details disclosed herein should not be construed as limiting, but merely as the basis for the claims and teachings to those skilled in the art. No numerical data or ranges used herein should be construed as limiting. 【0012】 The present invention relates to a hydrogel coating formulation and a method for producing the same, and more particularly, the hydrogel coating formulation is used to coat elastomer articles such as gloves, although it is not limited to the following. The hydrogel coating formulation of the present invention exhibits desired swelling properties, and gloves coated with the hydrogel coating formulation of the present invention exhibit desirable sweat absorption capacity, which helps to improve skin moisture retention and reduce transepidermal water loss from the user's skin. 【0013】 For the purposes of this invention, the term "inner surface" refers to the surface of the glove that comes into contact with the user's skin. For the purposes of this invention, the term "artificial sweat absorption capacity" refers to the total amount of artificial sweat absorbed. For the purposes of this invention, the term "skin moisture content" refers to the water content in the stratum corneum of the skin. For the purposes of this invention, the term "transepidermal water loss" refers to the amount of water that passively evaporates from the skin to the external environment due to the water vapor pressure gradient acting on both sides of the skin barrier. 【0014】 A first aspect of the present invention relates to a hydrogel coating formulation, which is used thereafter to form a coating layer on the inner surface of an elastomer article such as gloves, but is not limited to the present invention. The hydrogel coating formulation of the present invention has a pH value in the range of 3 to 5, a total solids content in the range of 1.24% to 2.82% by mass, and a viscosity in the range of 2.025 cP to 2.475 cP. 【0015】 This hydrogel coating formulation contains oat-beta-glucan, colloidal oatmeal, preservatives, carboxylic acids, initiators, crosslinking agents, pH adjusters, and solvents (composition as shown in Table 1). 【0016】 Oat beta-glucan is used in the hydrogel coating formulation in an amount ranging from 0.05% to 0.5% by mass, preferably between 0.1% and 0.4% by mass, and most preferably 0.28% by mass. Oat beta-glucan is used in powder form, and the oat beta-glucan powder has a particle size ranging from 45 μm to 300 μm. 【0017】 Colloidal oatmeal is used in the hydrogel coating formulation in an amount ranging from 0.05% to 0.5% by mass, preferably between 0.1% and 0.4% by mass, and most preferably 0.25% by mass. The colloidal oatmeal is used in powder form, and the colloidal oatmeal powder has a particle size ranging from 21 μm to 125 μm. 【0018】 The preservative is selected from the group consisting of sodium benzoate, benzoic acid, disodium ethylenediaminetetraacetate, calcium sorbate, and mixtures thereof, preferably sodium benzoate. The preservative is used in the hydrogel coating formulation in an amount between 0.01% and 0.2% by mass, preferably between 0.05% and 0.1% by mass, and most preferably 0.08% by mass. 【0019】 The carboxylic acid is selected from the group consisting of itaconic acid, acrylic acid, methacrylic acid, alginic acid, and mixtures thereof, preferably itaconic acid, and the carboxylic acid is used in the hydrogel coating formulation in an amount between 0.1% and 2% by mass, preferably between 0.56% and 1.12% by mass, and most preferably 0.84% ​​by mass. 【0020】 The initiator is selected from the group consisting of ammonium persulfate, sodium persulfate, potassium persulfate, tetramethylethylenediamine, and mixtures thereof, preferably ammonium persulfate, and the initiator is used in the hydrogel coating formulation in an amount between 0.01% by mass and 0.12% by mass, preferably between 0.03% by mass and 0.09% by mass, and most preferably 0.06% by mass. 【0021】 The crosslinking agent is selected from the group consisting of N-N'-methylenebisacrylamide, glutaraldehyde, gallic acid, and mixtures thereof, preferably N-N'-methylenebisacrylamide, and the crosslinking agent is used in the hydrogel coating formulation in an amount between 0.0005% by mass and 0.02% by mass, preferably between 0.001% by mass and 0.01% by mass, and most preferably 0.003% by mass. 【0022】 The pH regulator includes a first pH regulator and a second pH regulator. The pH regulator is used in an amount ranging from 0.2% to 1% by mass, preferably from 0.4% to 0.7% by mass, most preferably 0.56% by mass of the hydrogel coating formulation. The first pH regulator is selected from the group consisting of citric acid, ascorbic acid, and mixtures thereof, preferably citric acid, and the first pH regulator is used in an amount ranging from 0.1% to 0.5% by mass, preferably from 0.2% to 0.35% by mass, most preferably 0.28% by mass of the hydrogel coating formulation. The second pH regulator is selected from the group consisting of sodium hydroxide, potassium hydroxide, and mixtures thereof, preferably sodium hydroxide, and the second pH regulator is used in an amount ranging from 0.1% to 0.5% by mass, preferably from 0.2% to 0.35% by mass, most preferably 0.28% by mass of the hydrogel coating formulation. 【0023】 The solvent includes a first solvent and a second solvent. The first solvent and the second solvent are selected from the group consisting of distilled water, soft water, deionized water, ultrapure water, and mixtures thereof, preferably distilled water. The solvent is used in an amount ranging from 95.66% to 99.58% by mass, preferably from 97.18% to 98.76% by mass, most preferably 97.93% by mass of the hydrogel coating formulation. The first solvent is used in an amount ranging from 19.13% to 19.92% by mass, preferably from 19.44% to 19.75% by mass, most preferably 19.59% by mass of the hydrogel coating formulation. The second solvent is used in an amount ranging from 76.53% to 79.66% by mass, preferably from 77.74% to 79.01% by mass, most preferably 78.34% by mass of the hydrogel coating formulation. 【0024】 For the purposes of the present invention, the term "soft water" refers to water containing less than 17 ppm of ions such as calcium and magnesium, although not limited thereto. For the purposes of the present invention, the term "ultrapure water" refers to H2O, and the remainder is H + and OH -Refers to water that contains only the number of ions, has a resistivity of 18.2 MΩ.cm, total organic carbon less than 10 ppb, bacterial count less than 10 CFU / ml, and must not contain any detectable endotoxin. 【0025】 Table 1 shows the chemical components and composition of the hydrogel coating formulation of the present invention. 【0026】 [Table 1] 【0027】 The second aspect of the present invention is a method for preparing the hydrogel coating formulation of the present invention, as follows: i. A step of adding a first pH regulator and embac-β-glucan (composition according to Table 1) to a first solvent (composition according to Table 1) while stirring to produce a first mixture, wherein the first mixture is stirred at a temperature in the range of 85°C to 95°C, preferably 90°C, at a speed of 500 rpm to 1000 rpm, preferably 750 rpm, for 20 minutes to 40 minutes, preferably 30 minutes. ii. A step of adding a second pH regulator to a carboxylic acid (composition according to Table 1) while stirring to produce a second mixture, wherein the second mixture is stirred at a temperature in the range of 20°C to 30°C, preferably 25°C, at a speed of 300 rpm to 500 rpm, preferably 400 rpm, for 5 minutes to 15 minutes, preferably 10 minutes, and the second mixture has a pH of 4.5 and is a partially neutralized carboxylic acid. iii. A step of sequentially adding the second mixture obtained from step (ii), a cross-linking agent, and an initiator (composition according to Table 1) to the first mixture obtained from step (i) while stirring to produce a third mixture, wherein the third mixture is stirred at a temperature in the range of 65°C to 75°C, preferably 70°C, at a speed of 200 rpm to 400 rpm, preferably 300 rpm, for 160 minutes to 200 minutes, preferably 180 minutes. iv. A step of adding a second solvent (composition according to Table 1) to the third mixture obtained from step (iii) while stirring to produce a fourth mixture, wherein the fourth mixture is stirred for 10 to 20 minutes, preferably 15 minutes, at a temperature in the range of 20°C to 30°C, preferably 25°C, at a speed of 200 rpm to 400 rpm, preferably 300 rpm, and v. A step of producing the hydrogel coating formulation of the present invention by sequentially adding colloidal oatmeal and sodium benzoate (composition according to Table 1) to the fourth mixture obtained from step (iv) in no particular order, while stirring, wherein the hydrogel coating formulation of the present invention is stirred for 50 to 70 minutes, preferably 60 minutes, at a speed of 200 rpm to 400 rpm, preferably 300 rpm, at a temperature in the range of 20°C to 30°C, preferably 25°C. We will discuss methods, including the following. 【0028】 For the purposes of this invention, the phrase "sequentially without a specific order" means that the mixing order is not important, and that any one of the chemicals may be added first, followed by the other chemicals. 【0029】 The hydrogel coating formulation of the present invention is a water-based hydrogel coating formulation that can be used to create a hydrogel coating layer on gloves. For the purposes of the present invention, the term "hydrogel" refers to a three-dimensional polymer network structure that has hydrophilic properties that allow it to swell and that can hold a large amount of water in a swollen state while maintaining its structure. 【0030】 A third aspect of the present invention relates to gloves of the present invention coated with at least one layer of the hydrogel coating formulation of the present invention, the composition of which is described in Table 1. The gloves are prepared by employing any commonly known method in the glove manufacturing industry, in which case the method is as follows: i. A process for cleaning a mold to produce a cleaned mold, wherein the first step is a treatment using an acidic solution such as nitric acid (but not limited to the following), the second step is a treatment using an alkaline solution such as an aqueous sodium hydroxide solution (but not limited to the following), the third step is washing with hot water, and the fourth step is drying so that the surface of the mold is thoroughly cleaned. ii. A step of coating the mold surface with a coagulant layer by immersing the cleaned mold obtained in step (i) in a coagulant solution at a temperature in the range of 55°C to 65°C, wherein the coagulant solution is, but is not limited to, 10% to 20% by mass of calcium nitrate, etc. iii. A step of drying the solidifying agent layer coated on the mold surface obtained in step (ii) at a temperature in the range of 55°C to 65°C to obtain a dried solidifying agent layer. iv. A step of coating the mold surface with a latex layer by immersing the dried solidifying agent layer coated on the mold surface obtained in step (iii) in a latex immersion tank containing a latex compound at a temperature in the range of 40°C to 60°C. v. A step of drying the latex layer coated on the mold surface obtained in step (iv) at a temperature in the range of 80°C to 150°C to obtain a dried latex film. vi. A step to obtain a pre-eluted latex film by pre-eluting the dried latex film coated on the mold surface obtained in step (v) with warm water at a temperature in the range of 40°C to 60°C to dissolve and remove chemical residues. vii. A step to obtain vulcanized gloves by heating the pre-eluted latex film coated on the mold surface obtained in step (vi) at a temperature in the range of 80°C to 150°C to elute chemical residues. viii. A step of obtaining treated gloves by chlorinating the vulcanized gloves obtained in step (vii), wherein chlorine is used at an intensity of 800 ppm to 2000 ppm. ix. A step to neutralize the chlorous gloves obtained in step (viii) with alkali treatment and water to elute and remove chemical residues and obtain neutralized gloves. x. A step to obtain coated gloves by immersing the neutralized gloves obtained in step (ix) in an immersion tank containing the hydrogel coating formulation of the present invention (composition described in Table 1) at a temperature in the range of 55°C to 65°C, preferably 60°C, for a time in the range of 5 seconds to 20 seconds, preferably 10 seconds. xi. A step of drying the coated gloves obtained in step (x) to produce the gloves of the present invention, and xii. Step of removing the glove of the present invention obtained in step (xi) from the mold. Includes. 【0031】 The latex formulation mentioned in step iv can be any conventional latex formulation, preferably comprising a base polymer, an accelerator, a crosslinking agent, and an opacity enhancer (compositions listed in Table 2). 【0032】 The base polymer is selected from the group consisting of acrylonitrile butadiene rubber latex, natural rubber latex, polychloroprene latex, isoprene latex, and mixtures thereof. The base polymer is used in quantities of 100 phr (also called rubber percentage), which is used as a standard for expressing the quantity of other chemical substances. 【0033】 The accelerator is a carbamate-based accelerator. The accelerator is used in an amount ranging from 0.5 phr to 2.0 phr, preferably between 0.5 phr and 1.0 phr, and most preferably 0.75 phr. 【0034】 The crosslinking agent is selected from the group consisting of sulfur, zinc oxide, and mixtures thereof, preferably a mixture of sulfur and zinc oxide. The crosslinking agent is used in an amount in the range of 1.0 phr to 5.0 phr, preferably in the range of 2.0 phr to 4.0 phr, and most preferably in an amount of 3.0 phr. 【0035】 The opacity enhancer is titanium dioxide. The opacity enhancer is used in an amount between 0.5 phr and 2.0 phr, preferably between 0.7 phr and 1.8 phr, and most preferably at 1.5 phr. 【0036】 The pH adjuster is selected from the group consisting of ammonia, aqueous potassium hydroxide, and mixtures thereof, preferably ammonia. The pH adjuster is used in an amount in the range of 0.3 phr to 0.7 phr, preferably in the range of 0.4 phr to 0.6 phr, and most preferably in an amount of 0.5 phr. 【0037】 The solvent is selected from the group consisting of soft water, distilled water, and mixtures thereof, preferably soft water. The solvent is used in an amount in the range of 240 phr to 270 phr, preferably in the range of 250 phr to 260 phr, and most preferably 255 phr. 【0038】 Table 2 shows the chemical components and composition of the latex formulation of the present invention. 【0039】 [Table 2] 【0040】 The gloves of the present invention may be single-layered or multi-layered. [Examples] 【0041】 The following embodiments are provided to illustrate the present invention in a non-limiting sense. 【0042】 The gloves of the present invention are prepared using the latex formulations summarized in Table 2 and coated with the hydrogel coating formulations of the present invention summarized in Table 1, which employ any commonly known method in the glove manufacturing industry, in which case the hydrogel coating formulations are prepared according to the method described in the second aspect of the present invention. 【0043】 Test results of hydrogel coating formulations and gloves of the present invention The control non-hydrogel coating formulation contains oat beta-glucan in an amount of 0.28% by mass of the non-hydrogel coating formulation, colloidal oatmeal in an amount of 0.25% by mass of the non-hydrogel coating formulation, sodium benzoate in an amount of 0.08% by mass of the non-hydrogel coating formulation, and a solvent in an amount of 99.39% by mass of the non-hydrogel coating formulation, in which case the non-hydrogel coating formulation is prepared using any commonly known method in the coating manufacturing industry. The control glove refers to a glove having a non-hydrogel coating layer prepared from the non-hydrogel coating formulation discussed above. The control glove is prepared using any commonly known method in the glove manufacturing industry. 【0044】 On the other hand, the gloves of the present invention are prepared using the latex formulations summarized in Table 2 and coated with the hydrogel coating formulations of the present invention summarized in Table 1, which employ any commonly known method in the glove manufacturing industry, in which case the hydrogel coating formulations are prepared according to the method described in the second aspect of the present invention. 【0045】 The artificial sweat solution contains sodium chloride in an amount of 1.08% by mass, lactic acid (88%) in an amount of 0.12% by mass, and urea in an amount of 0.13% by mass. The remainder of the artificial sweat solution consists of a solvent, which is deionized water. The pH of the artificial sweat solution is adjusted to pH 6.5 with sodium hydroxide. 【0046】 Swelling capacity The control non-hydrogel coated formulation and the hydrogel coated formulation of the present invention are dried in an oven at a temperature of 50°C for 12 hours. Subsequently, the dried control non-hydrogel coated formulation and the hydrogel formulation of the present invention are placed into individual tea bags. Next, the mass of the tea bags together with the dried coated formulation is measured (M1). The tea bags together with the dried coated formulation are immersed in artificial sweat solution. Then, at time intervals of 5 minutes, 10 minutes, 15 minutes, 30 minutes, 45 minutes, and 60 minutes, these tea bags are removed from the artificial sweat solution and the mass of the immersed tea bags is measured (M2), but before measuring the mass, the immersed tea bags are gently patted dry using filter paper. 【0047】 The formula for calculating the swelling rate (%) of the coating compound is as follows: 【0048】 【number】 【0049】 Figure 1 shows the swelling rates of a control non-hydrogel coated formulation and the hydrogel coated formulation of the present invention. Based on the results obtained, it can be seen that the hydrogel coated formulation of the present invention has a superior swelling rate compared to the control non-hydrogel coated formulation. Therefore, the hydrogel coated formulation of the present invention improves the swelling capacity of gloves. This indicates that the gloves of the present invention can absorb more sweat, and as a result, this can reduce skin irritation to the user caused by sweat accumulation due to prolonged wear of gloves. 【0050】 Artificial sweat absorption capacity The mass of the control glove and the glove of the present invention is measured (W1). Next, the control glove and the glove of the present invention are placed in individual molds with their inner surfaces facing outwards, and dried in an oven at 60°C for 30 minutes. These molds are immersed in artificial sweat solution for 60 seconds. Next, these molds are removed from the artificial sweat solution and left to drip excess sweat from the glove surface for 10 minutes. Using filter paper, the droplets of artificial sweat solution on the fingertips of the gloves are gently patted dry. Next, the control glove and the glove of the present invention are peeled from the molds. Finally, the mass of the control glove and the glove of the present invention is measured (W2). Sweat absorption capacity (g) = W2 - W1 【0051】 Figure 2 shows the sweat absorption capacity of a control glove and a glove according to the present invention. Based on the results obtained, it can be seen that gloves having a coating layer prepared from the hydrogel coating formulation of the present invention have a superior sweat absorption capacity compared to the control glove. This indicates that the hydrogel coating formulation of the present invention improves the sweat absorption capacity of gloves. 【0052】 In vivo evaluation of skin characteristics (i.e., skin hydration and transepidermal water loss) in a nonclinical setting. For the purposes of this invention, the term "non-clinical setting" refers to a space or platform that does not involve human testing or treatment. 【0053】 For in vivo evaluation, the study will include 10 adults aged between 25 and 35 years. These participants will be randomly divided into two groups, Group A and Group B, each consisting of 5 participants. During the pre-stimulation period, participants in both Group A and Group B will be asked to wear uncoated nitrile gloves on both their left and right hands for 8 hours a day for 3 consecutive days for the purpose of pre-stimulation. The purpose of pre-stimulation is to reset the participants' baseline measurements by treating their hands under the same conditions as before the treatment period. 【0054】 Next, during the treatment period, subjects in Group A will be instructed to wear a control glove on their left hand and the glove of the present invention on their right hand for 8 hours a day for 4 consecutive days. Similarly, during the treatment period, subjects in Group B will be instructed to wear a control glove on their right hand and the glove of the present invention on their left hand for 8 hours a day for 4 consecutive days. During the pre-stimulation period and the treatment period, subjects in Groups A and B will be instructed to discard their gloves and wear new gloves every 2 hours, and will not be permitted to apply moisturizers. 【0055】 The transepidermal water loss (TEWL) of the subject is tested using a TEWL analyzer. Furthermore, the skin moisture content of the subject is tested using a skin moisture analyzer. Measurements (i.e., TEWL and skin moisture content) are taken under standard climatic conditions (21±1°C; 50±10% relative humidity) after at least 20 minutes of acclimatization. The measurements are expressed as the average of the TEWL and skin moisture content readings. 【0056】 The formula for calculating the percentage difference in TEWL is shown below: Percentage difference in TEWL (%) = (TEWL4 - TEWL1) / TEWL1 × 100 (In the formula, TEWL4 is the TEWL measurement taken on the 4th day of use, and TEWL1 is the TEWL measurement taken on the 1st day of use.) 【0057】 The formula for calculating the percentage difference in skin moisture content is shown below: Percentage difference in skin moisture content (%) = (SH4 - SH1) / SH1 × 100 (In the formula, SH4 is the skin moisture level measured on the 4th day of use, and SH1 is the skin moisture level measured on the 1st day of use.) 【0058】 Table 3 shows the average percentage difference in TEWL and skin moisture content for subjects (Groups A and B) who wore a control glove on one hand and the glove of the present invention on the other hand during the first and fourth days of use. 【0059】 Table 3 shows the average percentage difference in TEWL and skin moisture content between the subjects (Group A and Group B) on days 1 and 4 of the treatment period. 【0060】 [Table 3] 【0061】 Based on the results obtained in Table 3, it can be seen that the average percentage difference in skin moisture content of subjects wearing the gloves of the present invention is even higher than that of subjects wearing the control gloves. This indicates that gloves having a coating layer prepared from the hydrogel coating formulation of the present invention improve the skin moisture content of the user's skin. 【0062】 Furthermore, based on the results obtained in Table 3, it can be seen that the average percentage difference in TEWL for subjects wearing the gloves of the present invention is even lower than that for subjects wearing the control gloves. This indicates that gloves having a coating layer prepared from the hydrogel coating formulation of the present invention reduce the transepidermal water loss of the user's skin. 【0063】 Overall, gloves having a coating layer prepared from the hydrogel coating formulation of the present invention can overcome the drawbacks of conventional gloves by achieving desirable swelling properties and sweat absorption capacity, which help improve skin moisture retention and reduce transepidermal water loss from the user's skin. 【0064】 The technical terms used herein are intended solely to describe specific exemplary embodiments and are not intended to limit them. Where used herein, the singular forms “a,” “an,” and “the” are intended to include the plural forms as well, unless the context explicitly indicates otherwise. The terms “comprises,” “comprising,” “including,” and “having” are inclusive and thus indicate the existence of the specified features, integers, processes, operations, elements, and / or components, but do not preclude the existence or addition of one or more other features, integers, processes, operations, elements, components, and / or groups thereof. 【0065】 The methods, steps, processes, and operations described herein should be interpreted as not necessarily required to be performed in a specific order discussed or illustrated unless specifically identified as such. It should also be understood that additional or alternative steps may be used. The use of the expressions “at least” or “at least one” suggests the use of one or more elements, since their use may be present in one of the embodiments to achieve one or more desired objectives or results.

Claims

[Claim 1] A hydrogel coating formulation comprising oat beta-glucan, colloidal oatmeal, a preservative, a carboxylic acid, an initiator, a crosslinking agent, a pH adjuster and a solvent, wherein oat beta-glucan is used in an amount ranging from 0.05% to 0.5% by mass of the hydrogel coating formulation, colloidal oatmeal is used in an amount ranging from 0.05% to 0.5% by mass of the hydrogel coating formulation, a preservative is used in an amount ranging from 0.01% to 0.2% by mass of the hydrogel coating formulation, and a carboxylic acid is used as a hydrogel A hydrogel coating formulation in which an initiator is used in an amount ranging from 0.1% to 2% by mass of the hydrogel coating formulation, a crosslinking agent is used in an amount ranging from 0.0005% to 0.02% by mass of the hydrogel coating formulation, a pH adjusting agent is used in an amount ranging from 0.2% to 1% by mass of the hydrogel coating formulation, and a solvent is used in an amount ranging from 95.66% to 99.58% by mass of the hydrogel coating formulation. [Claim 2] The hydrogel coating formulation according to claim 1, wherein oat beta-glucan is used in an amount in the range of 0.1% to 0.4% by mass of the hydrogel coating formulation. [Claim 3] The hydrogel coating formulation according to claim 1, wherein colloidal oatmeal is used in an amount ranging from 0.1% by mass to 0.4% by mass of the hydrogel coating formulation. [Claim 4] The hydrogel coating formulation according to claim 1, wherein the preservative is selected from the group consisting of sodium benzoate, benzoic acid, disodium ethylenediaminetetraacetate, calcium sorbate, and mixtures thereof. [Claim 5] The hydrogel coating formulation according to claim 1, wherein the preservative is used in an amount between 0.05% by mass and 0.1% by mass of the hydrogel coating formulation. [Claim 6] The hydrogel coating formulation according to claim 1, wherein the carboxylic acid is selected from the group consisting of itaconic acid, acrylic acid, methacrylic acid, alginic acid, and mixtures thereof. [Claim 7] The hydrogel coating formulation according to claim 1, wherein the carboxylic acid is used in an amount ranging from 0.56% by mass to 1.12% by mass of the hydrogel coating formulation. [Claim 8] The hydrogel coating formulation according to claim 1, wherein the initiator is selected from the group consisting of ammonium persulfate, sodium persulfate, potassium persulfate, tetramethylethylenediamine, and mixtures thereof. [Claim 9] The hydrogel coating formulation according to claim 1, wherein the initiator is used in an amount ranging from 0.03% by mass to 0.09% by mass of the hydrogel coating formulation. [Claim 10] The hydrogel coating formulation according to claim 1, wherein the crosslinking agent is selected from the group consisting of N-N'-methylenebisacrylamide, glutaraldehyde, gallic acid, and mixtures thereof. [Claim 11] The hydrogel coating formulation according to claim 1, wherein the crosslinking agent is used in an amount in the range of 0.001% by mass to 0.01% by mass of the hydrogel coating formulation. [Claim 12] The hydrogel coating formulation according to claim 1, wherein the pH adjusting agent comprises a first pH adjusting agent and a second pH adjusting agent. [Claim 13] The hydrogel coating formulation according to claim 12, wherein the first pH adjusting agent is selected from the group consisting of citric acid, ascorbic acid, and mixtures thereof. [Claim 14] The hydrogel coating formulation according to claim 12, wherein the first pH adjusting agent is used in an amount ranging from 0.1% by mass to 0.5% by mass of the hydrogel coating formulation. [Claim 15] The hydrogel coating formulation according to claim 12, wherein the second pH adjusting agent is selected from the group consisting of sodium hydroxide, potassium hydroxide and mixtures thereof. [Claim 16] The hydrogel coating formulation according to claim 12, wherein the second pH adjusting agent is used in an amount ranging from 0.1% by mass to 0.5% by mass of the hydrogel coating formulation. [Claim 17] The hydrogel coating formulation according to claim 1, wherein the solvent is selected from the group consisting of distilled water, soft water, deionized water, ultrapure water, and mixtures thereof. [Claim 18] The hydrogel coating formulation according to claim 1, wherein the solvent is used in an amount ranging from 97.18% by mass to 98.76% by mass of the hydrogel coating formulation. [Claim 19] A glove coated with at least one coating layer prepared from a hydrogel coating formulation according to any one of claims 1 to 18. [Claim 20] A method for preparing a hydrogel coating formulation, i. A step of adding a first pH adjusting agent and oat beta-glucan to a first solvent while stirring to produce a first mixture, wherein the first mixture is stirred at a speed of 500 rpm to 1000 rpm for 20 to 40 minutes at a temperature in the range of 85°C to 95°C. ii. A step of adding a second pH adjusting agent to a carboxylic acid while stirring to produce a second mixture, wherein the second mixture is stirred at a speed of 300 rpm to 500 rpm for 5 to 15 minutes at a temperature in the range of 20°C to 30°C. iii. A step of sequentially adding the second mixture obtained from step (ii), a crosslinking agent, and an initiator to the first mixture obtained from step (i) while stirring to produce a third mixture, wherein the third mixture is stirred at a speed of 200 rpm to 400 rpm for 160 to 200 minutes at a temperature in the range of 65°C to 75°C. iv. A step of adding a second solvent to the third mixture obtained from step (iii) while stirring to produce a fourth mixture, wherein the fourth mixture is stirred at a speed of 200 rpm to 400 rpm for 10 to 20 minutes at a temperature in the range of 20°C to 30°C, and v. A step of producing a hydrogel coating formulation by sequentially adding colloidal oatmeal and sodium benzoate to the fourth mixture obtained from step (iv) in no particular order, while stirring, wherein the hydrogel coating formulation is stirred at a speed of 200 rpm to 400 rpm for 50 to 70 minutes at a temperature in the range of 20°C to 30°C. Methods that include... [Claim 21] A glove coated with at least one layer of a hydrogel coating formulation prepared by the method of claim 20.

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