Compositions containing metal-organic structures for inducing dendritic cell differentiation and their uses

Abstract

The present invention relates to a dendritic cell differentiation induction composition containing a metal-organic structure and its uses, wherein the composition not only increases the expression of surface protein indicators of dendritic cells, but also induces differentiation into dendritic cells with improved viability and mobility when administered to an organism.

Claims

1. A composition for inducing dendritic cell differentiation, comprising a metal-organic framework (MOF).

2. The aforementioned metal-organic structure is a metal cluster; and The dendritic cell differentiation induction composition according to claim 1, comprising a ligand compound represented by the following chemical formula 1 that coordinates to the metal cluster: Here, m is an integer between 0 and 4. R １ This includes hydrogen, deuterium, cyano groups, nitro groups, amino groups, halogen groups, hydroxyl groups, substituted or unsubstituted C1-C4 alkylthio groups, substituted or unsubstituted C1-C30 alkyl groups, substituted or unsubstituted C3-C20 cycloalkyl groups, substituted or unsubstituted C2-C30 alkenyl groups, substituted or unsubstituted C2-C24 alkynyl groups, substituted or unsubstituted C7-C30 aralkyl groups, substituted or unsubstituted C6-C30 aryl groups, substituted or unsubstituted C1-C60 heteroaryl groups, and substituted or unsubstituted carbon Selected from the group consisting of a heteroarylalkyl group having 2 to 30 prime numbers, a substituted or unsubstituted alkoxy group having 1 to 30 carbon atoms, a substituted or unsubstituted alkylamino group having 1 to 30 carbon atoms, a substituted or unsubstituted arylamino group having 6 to 30 carbon atoms, a substituted or unsubstituted aralkylamino group having 7 to 30 carbon atoms, a substituted or unsubstituted heteroarylamino group having 1 to 24 carbon atoms, a substituted or unsubstituted alkylsilyl group having 1 to 30 carbon atoms, a substituted or unsubstituted arylsilyl group having 6 to 30 carbon atoms, and a substituted or unsubstituted aryloxy group having 6 to 30 carbon atoms.

3. The aforementioned R １ The dendritic cell differentiation induction composition according to claim 2, wherein is selected from the group consisting of an amino group, a substituted or unsubstituted alkylamino group having 1 to 30 carbon atoms, a substituted or unsubstituted arylamino group having 6 to 30 carbon atoms, a substituted or unsubstituted aralkylamino group having 7 to 30 carbon atoms, and a substituted or unsubstituted heteroarylamino group having 1 to 24 carbon atoms.

4. The dendritic cell differentiation induction composition according to claim 1, wherein the metal-organic structure comprises one or more metals or metal ions selected from the group consisting of aluminum (Al), iron (Fe), and zirconium (Zr).

5. A method for inducing dendritic cell differentiation, comprising the step of treating immature dendritic cells with the composition according to any one of claims 1 to 4, and then culturing them.

6. The method for inducing dendritic cell differentiation according to claim 5, wherein the immature dendritic cells are cells obtained by treating bone marrow cells with granulocyte-macrophage colony-stimulating factor (GM-CSF).

7. Dendritic cells differentiated by the differentiation induction method described in claim 5.

8. The dendritic cell according to claim 7, wherein the expression of one or more surface protein indicators selected from the group consisting of CD40, CD80, CD86, MHC class I, and MHC class II is increased.

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