Tetrahydronaptyridine and related analogues for inhibiting YAP / TAZ-TEAD

Novel compounds targeting YAP/TAZ-TEAD transcription provide effective treatment for a variety of cancers and fibrosis by inhibiting YAP/TAZ-TEAD activation, addressing the need for improved therapeutic options with reduced side effects and enhanced pharmacokinetics.

JP2026522165APending Publication Date: 2026-07-07SPRINGWORKS THERAPEUTICS INC +2
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Patent Information

Application Number
JP2025560766
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-05-16
Filing Date
2024-05-16
Publication Date
2026-07-07

AI Technical Summary

Technical Problem

There is a need for novel, alternative, and/or better treatments for YAP/TAZ-TEAD activation-mediated diseases, particularly cancer and fibrosis, with improved potency, fewer side effects, lower toxicity, and better pharmacokinetic properties.

Method used

Development of novel compounds that inhibit YAP/TAZ-TEAD transcription, effectively targeting various cancers and fibrotic diseases by inhibiting YAP/TAZ-TEAD activation.

Benefits of technology

These compounds demonstrate potent inhibitory activity against YAP/TAZ-TEAD transcription, offering therapeutic benefits for a wide range of cancers and fibrotic conditions, including lung, breast, and skin cancers, as well as fibrosis, with potential for reduced side effects and improved pharmacokinetic properties.

✦ Generated by Eureka AI based on patent content.

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Abstract

This disclosure relates to novel compounds for use as pharmaceuticals, more specifically for the prevention or treatment of diseases mediated by the activity of YAP / TAZ-TEAD transcription, and even more specifically for the prevention or treatment of cancer or fibrosis. This disclosure also relates to methods for the prevention or treatment of the aforementioned diseases, including the use of novel compounds.
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