SMARCA2 decomposing agent and its use

Abstract

The present disclosure provides a compound represented by formula (A), or a pharmaceutically acceptable salt and / or stereoisomer thereof, 【Chemical 1】 JPEG2026522353001578.jpg39128In the formula, R a 、R b 、R 7 、R 8 、R 9 、R 10 、R 12 、R 12a 、R 12b 、R 12c 、m, X 3 、W, L, and E are as defined herein. The compound represented by formula (A) is a SMARCA2 proteolytic enzyme and is thus useful for treating cancer and other diseases.

Claims

1. Formula (A): 【Chemistry 1】 A compound having, or a pharmaceutically acceptable salt and / or stereoisomer thereof, During the ceremony, E is, 【Chemistry 2】 And, R １ is hydrogen, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) Alkyl, or 【Transformation 3】 And, R ２ is hydrogen, halogen, (C １ ~C ６ -C １ ~C ６ -alkoxy, or 【Chemistry 4】 And, however, (i) R １ However, hydrogen, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) If it is an alkoxy, R ２ teeth, 【Transformation 5】 And, (ii) R ２ However, hydrogen, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) If it is an alkoxy, R １ teeth, 【Transformation 6】 And, R １１ is hydrogen or -(C １ ~C ６ ) alkyl-O-P(=O)-(OH) ２ And, X １ CR ３ or N, R ３ is hydrogen, halogen, or (C １ ~C ６ ) is alkyl, X ２ CR ４ or N, R ４ is hydrogen, halogen, or (C １ ~C ６ ) is alkyl, R ５ａ is hydrogen, halogen, (C １ ~C ６ ) alkyl, (C ３ ~C ６ ) Cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, where (C １ ~C ６ ) Alkyl is optionally substituted with one, two, or three substituents independently selected from halogens or cyanos, and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is substituted with halogens, cyanos, or (C １ ~C ６ ) optionally substituted with one, two, or three substituents independently selected from the alkyl group, R ５ｂ is hydrogen, (C １ ~C ６ ) alkyl, or (C ３ ~C ６ ) It is a cycloalkyl, R ６ is hydrogen, (C １ ~C ６ ) Alkyl or cyano, X ３ is, -(CR １３ａ R １３ｂ ) ｎ - or -O-, n is either 0 or 1, Each R １３ａ and R １３ｂ These are, independently, hydrogen, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) is an alkoxy, L is -G １ -G ２ -G ３ -G ４ - and here, G １ It is bonded to W, G １ is halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) 4- to 6-membered heterocycloalkylenes, halogens, (C) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano. １ ~C ６ ) alkyl, (C １ ~C ６ ) 7- to 11-membered heterocycloalkylenes or halogens, optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano (C ３ ~C ６ ) It is a cycloalkylene, G ２ is, (C １ ~C ６ ) Alkylene, -C(=O)-, or direct bond, G ３ is a 4- to 7-member heterocycloalkylene optionally substituted with 1, 2, or 3 substituents independently selected from halogen, (C １ ~C ６ )-alkyl, (C １ ~C ６ )-alkoxy, or cyano, a halogen, (C １ ~C ６ )-alkyl, (C １ ~C ６ )-alkoxy, or cyano, or a 7- to 11-member heterocycloalkylene optionally substituted with 1, 2, or 3 substituents independently selected from halogen, (C １ ~C ６ )-alkyl, (C １ ~C ６ )-alkoxy, or cyano, or a (C ３ ~C ６ )-cycloalkylene optionally substituted with 1, 2, or 3 substituents independently selected from halogen, (C ), and is G ４ is, (C １ ~C ６ ) Alkylene or direct bond, W is -C (=O)-, -CH ２ -, or direct bond, R ７ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. R ８ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. R ９ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. R １０ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. Each R １２ These are, independently, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) is an alkoxy, m is 0, 1, 2, 3, or 4. R １２ａ and R １２ｂ These are, independently, hydrogen, halogen, and (C １ ~C ６ ) alkyl, (C １ ~C ６ ) is an alkoxy, and here, (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens, or R １２ａ and R １２ｂ These, together with the carbon atoms to which they are bonded, are optionally substituted with 5- to 7-membered heterocycloalkyl groups or optionally substituted with (C ５ ~C ７ ) form a cycloalkyl group, R １２ｃ is hydrogen or halogen, R ａ is hydrogen or halogen, R ｂ A compound that is hydrogen or a halogen, or a pharmaceutically acceptable salt and / or stereoisomer thereof.

2. Equation (I): 【Transformation 7】 A compound having, or a pharmaceutically acceptable salt and / or stereoisomer thereof, During the ceremony, E is, 【Transformation 8】 And, R １ is hydrogen, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) Alkyl, or 【Chemistry 9】 And, R ２ is hydrogen, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) Alkyl, or 【Chemistry 10】 And, however, (i) R １ However, hydrogen, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) If it is an alkoxy, R ２ teeth, 【Chemistry 11】 And, (ii) R ２ However, hydrogen, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) If it is an alkoxy, R １ teeth, 【Chemistry 12】 And, R １１ is hydrogen or -(C １ ~C ６ ) alkyl-O-P(=O)-(OH) ２ And, X １ CR ３ or N, R ３ is hydrogen, halogen, or (C １ ~C ６ ) is alkyl, X ２ CR ４ or N, R ４ is hydrogen, halogen, or (C １ ~C ６ ) is alkyl, R ５ａ is hydrogen, halogen, (C １ ~C ６ ) alkyl, (C ３ ~C ６ ) Cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, where (C １ ~C ６ ) Alkyl is optionally substituted with one, two, or three substituents independently selected from halogens or cyanos, and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is substituted with halogens, cyanos, or (C １ ~C ６ ) optionally substituted with one, two, or three substituents independently selected from the alkyl group, R ５ｂ is hydrogen, (C １ ~C ６ ) alkyl, or (C ３ ~C ６ ) It is a cycloalkyl, R ６ is hydrogen, (C １ ~C ６ ) Alkyl or cyano, X ３ is, -(CR １３ａ R １３ｂ ) ｎ - or -O-, n is either 0 or 1, Each R １３ａ and R １３ｂ These are independently H, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) is an alkoxy, L is -G １ -G ２ -G ３ -G ４ - and here, G １ It is bonded to W, G １ is halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) 4- to 6-membered heterocycloalkylenes, halogens, (C) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano. １ ~C ６ ) alkyl, (C １ ~C ６ ) 7- to 11-membered heterocycloalkylenes or halogens, optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano (C ３ ~C ６ ) It is a cycloalkylene, G ２ is, (C １ ~C ６ ) Alkylene or direct bond, G ３ is halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) 4- to 6-membered heterocycloalkylenes, halogens, (C) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano. １ ~C ６ ) alkyl, (C １ ~C ６ ) 7- to 11-membered heterocycloalkylenes or halogens, optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano (C ３ ~C ６ ) It is a cycloalkylene, G ４ is, (C １ ~C ６ ) Alkylene or direct bond, W is -C (=O)-, R ７ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. R ８ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. R ９ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. R １０ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. Each R １２ These are, independently, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) is an alkoxy, A compound, or a pharmaceutically acceptable salt and / or stereoisomer thereof, where m is 0, 1, 2, 3, or 4.

3. Formula (IA): 【Chemistry 13】 A compound having, or a pharmaceutically acceptable salt and / or stereoisomer thereof, During the ceremony, E is, 【Chemistry 14】 And, R １ is hydrogen, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) Alkyl, or 【Chemistry 15】 And, R ２ is hydrogen, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) Alkyl, or 【Chemistry 16】 And, however, (i) R １ However, hydrogen, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) If it is an alkoxy, R ２ teeth, 【Chemistry 17】 And, (ii) R ２ However, hydrogen, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) If it is an alkoxy, R １ teeth, [Chemistry 18] And, R １１ is hydrogen or -(C １ ~C ６ ) alkyl-O-P(=O)-(OH) ２ And, X １ CR ３ or N, R ３ is hydrogen, halogen, or (C １ ~C ６ ) is alkyl, X ２ CR ４ or N, R ４ is hydrogen, halogen, or (C １ ~C ６ ) is alkyl, R ５ａ is hydrogen, halogen, (C １ ~C ６ ) alkyl, (C ３ ~C ６ ) Cycloalkyl, 4- to 6-membered heterocycloalkyl, cyano, aryl, or 5- or 6-membered heteroaryl, where (C １ ~C ６ ) Alkyl is optionally substituted with one, two, or three substituents independently selected from halogens or cyanos, and 4- to 6-membered heterocycloalkyl, aryl, or 5- or 6-membered heteroaryl is substituted with halogens, cyanos, or (C １ ~C ６ ) optionally substituted with one, two, or three substituents independently selected from the alkyl group, R ５ｂ is hydrogen, (C １ ~C ６ ) alkyl, or (C ３ ~C ６ ) It is a cycloalkyl, R ６ is hydrogen, (C １ ~C ６ ) Alkyl or cyano, X ３ is, -(CR １３ａ R １３ｂ ) ｎ - or -O-, n is either 0 or 1, Each R １３ａ and R １３ｂ These are, independently, hydrogen, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ ) is an alkoxy, L is -G １ -G ２ -G ３ -G ４ - and here, G １ It is bonded to W, G １ is halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) 4- to 6-membered heterocycloalkylenes, halogens, (C) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano. １ ~C ６ ) alkyl, (C １ ~C ６ ) 7- to 11-membered heterocycloalkylenes or halogens, optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano (C ３ ~C ６ ) It is a cycloalkylene, G ２ is, (C １ ~C ６ ) Alkylene, -C(=O)-, or direct bond, G ３ is halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) 4- to 7-membered heterocycloalkylenes, halogens, (C) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano. １ ~C ６ ) alkyl, (C １ ~C ６ ) 7- to 11-membered heterocycloalkylenes or halogens, optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano (C ３ ~C ６ ) It is a cycloalkylene, G ４ is, (C １ ~C ６ ) Alkylene or direct bond, W is -C (=O)-, -CH ２ -, or direct bond, R ７ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. R ８ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. R ９ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. R １０ is hydrogen, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens. R １２ａ and R １２ｂ These are, independently, hydrogen, halogen, and (C １ ~C ６ ) alkyl, (C １ ~C ６ ) is an alkoxy, and here, (C １ ~C ６ ) The alkyl group is optionally substituted with one, two, or three halogens, or R １２ａ and R １２ｂ These, together with the carbon atoms to which they are bonded, are optionally substituted with 5- to 7-membered heterocycloalkyl groups or optionally substituted with (C ５ ~C ７ ) form a cycloalkyl group, R １２ｃ A compound that is hydrogen or a halogen, or a pharmaceutically acceptable salt and / or stereoisomer thereof.

4. Formula (II): 【Chemistry 19】 A compound according to claim 1 or 2, or a pharmaceutically acceptable salt thereof, having the above.

5. Formula (III): 【Chemistry 20】 A compound according to claim 1 or 2, or a pharmaceutically acceptable salt thereof, having the above.

6. X ３ ga- (CR １３ａ R １３ｂ ) - a compound according to any one of claims 1 to 5, or a pharmaceutically acceptable salt thereof.

7. R １３ａ and R １３ｂ The compound according to claim 6, or a pharmaceutically acceptable salt thereof, wherein the compound is hydrogen.

8. R １３ａ and R １３ｂ The compound according to claim 6, or a pharmaceutically acceptable salt thereof, wherein is fluoro.

9. R １３ａ is methyl or methoxy, and R １３ｂ The compound according to claim 6, or a pharmaceutically acceptable salt thereof, wherein the compound is hydrogen.

10. X ３ A compound according to any one of claims 1 to 5, wherein the compound is -O-, or a pharmaceutically acceptable salt thereof.

11. A compound according to any one of claims 1, 2, or 4 to 10, wherein m is 0, or a pharmaceutically acceptable salt thereof.

12. A compound according to any one of claims 1, 2, or 4 to 10, wherein m is 2, or a pharmaceutically acceptable salt thereof.

13. A compound according to any one of claims 1, 2, or 4 to 10, wherein m is 1, or a pharmaceutically acceptable salt thereof.

14. Formula (IV): 【Chemistry 21】 A compound according to claim 2, or a pharmaceutically acceptable salt thereof, having the above.

15. Formula (V): 【Chemistry 22】 A compound according to claim 2, or a pharmaceutically acceptable salt thereof, having the above.

16. Each R １２ The compound according to any one of claims 13 to 15, wherein the compound is fluoro, methyl, ethyl, or methoxy, or a pharmaceutically acceptable salt thereof.

17. Formula (VIII): 【Chemistry 23】 A compound according to claim 3, or a pharmaceutically acceptable salt thereof, having the above.

18. Formula (IX): 【Chemistry 24】 A compound according to any one of claims 3 or 17, or a pharmaceutically acceptable salt thereof, having the above.

19. R １２ａ is hydrogen, R １２ｂ A compound according to any one of claims 3, 17, or 18, or a pharmaceutically acceptable salt thereof, wherein is hydrogen, fluoro, methyl, ethyl, or methoxy.

20. Formula (X): 【Chemistry 25】 It has, During the ceremony, X ４ is O, The compound according to claim 3, a pharmaceutically acceptable salt and / or stereoisomer thereof, wherein d and e are independently 1 or 2.

21. Formula (XI): 【Chemistry 26】 It has, During the ceremony, X ４ is O, The compound according to claim 3, or a pharmaceutically acceptable salt thereof, wherein d and e are independently 1 or 2.

22. Equation (XII): 【Chemistry 27】 It has, During the ceremony, X ４ is O, The compound according to claim 3, or a pharmaceutically acceptable salt thereof, wherein d and e are independently 1 or 2.

23. A compound according to any one of claims 1 to 22, wherein E is E-1, or a pharmaceutically acceptable salt thereof.

24. R ５ａ The compound according to claim 23, or a pharmaceutically acceptable salt thereof, wherein the compound is hydrogen.

25. R ５ａ However, it is optionally substituted with one, two, or three substituents independently selected from halogens or cyano compounds (C １ ~C ６ The compound according to claim 23, or a pharmaceutically acceptable salt thereof, wherein the compound is alkyl.

26. R ５ａ However, methyl, ethyl, isopropyl, or -CF ３ The compound according to claim 25, or a pharmaceutically acceptable salt thereof.

27. R ５ａ But (C ３ ~C ６ The compound according to claim 23, or a pharmaceutically acceptable salt thereof, which is a cycloalkyl compound.

28. R ５ａ The compound according to claim 27, wherein is cyclopropyl, or a pharmaceutically acceptable salt thereof.

29. R ５ａ However, halogen, cyano, or (C １ ~C ６ The compound according to claim 23, or a pharmaceutically acceptable salt thereof, which is a 4-membered to 6-membered heterocycloalkyl group optionally substituted with one, two, or three substituents independently selected from the alkyl group.

30. R ５ａ The compound according to claim 23, or a pharmaceutically acceptable salt thereof, wherein the compound is cyano.

31. R ５ａ However, halogen, cyano, or (C １ ~C ６ The compound according to claim 23, or a pharmaceutically acceptable salt thereof, wherein the aryl is optionally substituted with one, two, or three substituents independently selected from the alkyl.

32. R ５ａ However, halogen, cyano, or (C １ ~C ６ The compound according to claim 23, or a pharmaceutically acceptable salt thereof, which is a five-membered or six-membered heteroaryl that is optionally substituted with one, two, or three substituents independently selected from the alkyl group.

33. A compound according to any one of claims 1 to 22, wherein E is E-2, or a pharmaceutically acceptable salt thereof.

34. R ５ｂ The compound according to claim 33, or a pharmaceutically acceptable salt thereof, wherein the compound is hydrogen.

35. R ５ｂ But (C １ ~C ６ The compound according to claim 33, or a pharmaceutically acceptable salt thereof, wherein the compound is alkyl.

36. R ５ｂ The compound according to claim 35, or a pharmaceutically acceptable salt thereof, wherein is methyl.

37. R ５ｂ But (C ３ ~C ６ The compound according to claim 33, or a pharmaceutically acceptable salt thereof, which is a cycloalkyl compound.

38. R ５ｂ The compound according to claim 37, or a pharmaceutically acceptable salt thereof, wherein is cyclopropyl or cyclobutyl.

39. R ６ A compound according to any one of claims 1 to 38, wherein the compound is hydrogen, or a pharmaceutically acceptable salt thereof.

40. R ６ But (C １ ~C ６ A compound according to any one of claims 1 to 38, which is alkyl, or a pharmaceutically acceptable salt thereof.

41. R ６ A compound according to any one of claims 1 to 38, wherein the compound is cyano, or a pharmaceutically acceptable salt thereof.

42. R １ but, 【Chemistry 28】 And, R ２ However, hydrogen, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ A compound according to any one of claims 1 to 41, or a pharmaceutically acceptable salt thereof, which is an alkoxy.

43. R ２ However, hydrogen, halogen, or (C １ ~C ６ The compound according to claim 42, or a pharmaceutically acceptable salt thereof, wherein the compound is alkyl.

44. R ２ The compound according to claim 43, or a pharmaceutically acceptable salt thereof, wherein the compound is hydrogen, fluoro, or methyl.

45. R １１ A compound according to any one of claims 42 to 44, wherein the compound is hydrogen, or a pharmaceutically acceptable salt thereof.

46. R ２ but, 【Chemistry 29】 And, R １ However, hydrogen, halogen, (C １ ~C ６ ) alkyl, or (C １ ~C ６ A compound according to any one of claims 1 to 44, or a pharmaceutically acceptable salt thereof, which is an alkoxy.

47. R １ However, hydrogen, halogen, or (C １ ~C ６ The compound according to claim 46, or a pharmaceutically acceptable salt thereof, which is alkyl.

48. R １ The compound according to claim 46, or a pharmaceutically acceptable salt thereof, wherein the compound is hydrogen, fluoro, or methyl.

49. R １１ A compound according to any one of claims 46 to 48, wherein is hydrogen, or a pharmaceutically acceptable salt thereof.

50. X １ CR ３ The compound according to any one of claims 1 to 49, or a pharmaceutically acceptable salt thereof.

51. R ３ The compound according to claim 50, or a pharmaceutically acceptable salt thereof, wherein the compound is hydrogen.

52. R ３ The compound according to claim 50, or a pharmaceutically acceptable salt thereof, wherein is a halogen.

53. R ３ The compound according to claim 52, or a pharmaceutically acceptable salt thereof, wherein is fluoro.

54. R ３ But (C １ ~C ６ The compound according to claim 50, or a pharmaceutically acceptable salt thereof, wherein the compound is alkyl.

55. R ３ The compound according to claim 54, or a pharmaceutically acceptable salt thereof, wherein is methyl.

56. X １ A compound according to any one of claims 1 to 49, wherein is N, or a pharmaceutically acceptable salt thereof.

57. X ２ CR ４ The compound according to any one of claims 1 to 56, or a pharmaceutically acceptable salt thereof.

58. R ４ The compound according to claim 57, or a pharmaceutically acceptable salt thereof, wherein the compound is hydrogen.

59. R ４ The compound according to claim 57, or a pharmaceutically acceptable salt thereof, wherein is a halogen.

60. R ４ The compound according to claim 59, or a pharmaceutically acceptable salt thereof, wherein is fluoro.

61. R ４ But (C １ ~C ６ The compound according to claim 57, or a pharmaceutically acceptable salt thereof, wherein the compound is alkyl.

62. R ４ The compound according to claim 61, wherein is methyl, or a pharmaceutically acceptable salt thereof.

63. X ２ A compound according to any one of claims 1 to 56, wherein is N, or a pharmaceutically acceptable salt thereof.

64. E-1 is 【Transformation 30】 【Chemistry 31】 The compound according to claim 23.

65. E-2, 【Chemistry 32】 The compound according to claim 33.

66. G １ However, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ A compound according to any one of claims 1 to 65, or a pharmaceutically acceptable salt thereof, which is a four-membered to six-membered heterocycloalkylene optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano.

67. G １ but, 【Transformation 33】 And, Each R １４ These are, independently, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) Alkyl or cyano, n is 0, 1, 2, or 3. " ＊ The bond marked with " is G ２ A compound according to claim 66, or a pharmaceutically acceptable salt thereof, which is bonded to.

68. The compound according to claim 67, or a pharmaceutically acceptable salt thereof, wherein n is 0.

69. R １４ The compound according to claim 67, or a pharmaceutically acceptable salt thereof, wherein n is fluoro, methyl, or methoxy, and n is 1 or 2.

70. G １ but, 【Transformation 34】 And, " ＊ The bond marked with " is G ２ A compound according to claim 66, or a pharmaceutically acceptable salt thereof, which is bonded to.

71. G １ However, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano (C ３ ~C ６ A compound according to any one of claims 1 to 65, which is a cycloalkylene, or a pharmaceutically acceptable salt thereof.

72. G １ However, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ A compound according to any one of claims 1 to 65, or a pharmaceutically acceptable salt thereof, which is a 7-membered to 11-membered heterocycloalkylene optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano.

73. G １ but, 【Chemistry 35】 And, " ＊ The bond marked with " is G ２ A compound according to claim 72, or a pharmaceutically acceptable salt thereof, which is bonded to.

74. G ２ A compound according to any one of claims 1 to 73, or a pharmaceutically acceptable salt thereof, wherein the bond is a direct bond.

75. G ２ But (C １ ~C ６ A compound according to any one of claims 1 to 73, which is an alkylene, or a pharmaceutically acceptable salt thereof.

76. G ２ However, -CH ２ - or -CH(CH ３ ) - the compound according to claim 75, or a pharmaceutically acceptable salt thereof.

77. G ２ A compound according to claims 1 to 73, wherein is -C(=O)-, or a pharmaceutically acceptable salt thereof.

78. G ３ However, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ A compound according to any one of claims 1 to 73, or a pharmaceutically acceptable salt thereof, which is a four-membered to six-membered heterocycloalkylene optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano.

79. G ３ but, 【Transformation 36】 And, " ＊ The bond marked with " is G ４ A compound according to claim 78, or a pharmaceutically acceptable salt thereof, which is bonded to.

80. G ３ However, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ A compound according to any one of claims 1 to 77, or a pharmaceutically acceptable salt thereof, which is a 4-membered to 7-membered heterocycloalkylene optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano.

81. G ３ but, 【Chemistry 37】 And, " ＊ The bond marked with " is G ４ A compound according to claim 80, or a pharmaceutically acceptable salt thereof, which is bonded to.

82. G ３ However, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ A compound according to any one of claims 1 to 77, or a pharmaceutically acceptable salt thereof, which is a 7-membered to 11-membered heterocycloalkylene optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano.

83. G ３ but, 【Transformation 38】 And, " ＊ The bond marked with " is G ４ A compound according to claim 82, or a pharmaceutically acceptable salt thereof, which is bonded to.

84. G ３ but, 【Chemistry 39】 And, Each R １５ These are, independently, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) Selected from alkoxy or cyano, u is 0, 1, 2, or 3. v, w, x, and t are independently 1, 2, or 3. " ＊ The bond marked with " is G ４ A compound according to claim 82, or a pharmaceutically acceptable salt thereof, which is bonded to.

85. The compound according to claim 84, or a pharmaceutically acceptable salt thereof, wherein v, w, x, and y are independently 1 or 2.

86. G ３ but, 【Chemistry 40】 And, " ＊ The bond marked with " is G ４ A compound according to claim 85, or a pharmaceutically acceptable salt thereof, which is bonded to.

87. G ３ However, halogen, (C １ ~C ６ ) alkyl, (C １ ~C ６ ) optionally substituted with one, two, or three substituents independently selected from alkoxy or cyano (C ３ ~C ６ A compound according to any one of claims 1 to 77, which is a cycloalkylene, or a pharmaceutically acceptable salt thereof.

88. G ４ But (C １ ~C ６ ) A compound according to any one of claims 1 to 87, which is an alkylene, or a pharmaceutically acceptable salt thereof.

89. G ４ A compound according to any one of claims 1 to 87, wherein the bond is a direct bond, or a pharmaceutically acceptable salt thereof.

90. L, 【Chemistry 41】 【Chemistry 42】 And, " ＊ The bonds marked with " are bonded to E, the compound according to any one of claims 1 to 65, or a pharmaceutically acceptable salt thereof.

91. R ７ However, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ The alkyl group is optionally substituted with one, two, or three halogens, the compound according to any one of claims 1 to 90, or a pharmaceutically acceptable salt thereof.

92. R ７ However, halogen or (C １ ~C ６ The compound according to claim 91, or a pharmaceutically acceptable salt thereof, wherein the compound is alkyl.

93. R ７ The compound according to claim 92, or a pharmaceutically acceptable salt thereof, wherein the compound is fluoro or methyl.

94. R ８ , R ９ , and R １０ A compound according to any one of claims 91 to 93, wherein the compound is hydrogen, or a pharmaceutically acceptable salt thereof.

95. R ８ However, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ The alkyl group is optionally substituted with one, two, or three halogens, the compound according to any one of claims 1 to 90, or a pharmaceutically acceptable salt thereof.

96. R ８ However, halogen or (C １ ~C ６ The compound according to claim 95, or a pharmaceutically acceptable salt thereof, wherein the compound is alkyl.

97. R ８ The compound according to claim 96, or a pharmaceutically acceptable salt thereof, wherein the compound is fluoro or methyl.

98. R ７ , R ９ , and R １０ A compound according to any one of claims 95 to 97, wherein is hydrogen, or a pharmaceutically acceptable salt thereof.

99. R ９ However, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ The alkyl group is optionally substituted with one, two, or three halogens, the compound according to any one of claims 1 to 90, or a pharmaceutically acceptable salt thereof.

100. R ９ The compound according to claim 99, or a pharmaceutically acceptable salt thereof, wherein is a halogen.

101. R ９ The compound according to claim 100, or a pharmaceutically acceptable salt thereof, wherein is fluoro.

102. R ７ , R ８ , and R １０ A compound according to any one of claims 99 to 101, wherein the compound is hydrogen, or a pharmaceutically acceptable salt thereof.

103. R １０ However, halogen, (C １ ~C ６ ) alkyl, cyano, or (C ３ ~C ６ ) is a cycloalkyl, where (C １ ~C ６ The alkyl group is optionally substituted with one, two, or three halogens, the compound according to any one of claims 1 to 90, or a pharmaceutically acceptable salt thereof.

104. R １０ The compound according to claim 103, or a pharmaceutically acceptable salt thereof, wherein is a halogen.

105. R １０ The compound according to claim 104, or a pharmaceutically acceptable salt thereof, wherein is fluoro.

106. R ７ , R ８ , and R ９ A compound according to any one of claims 103 to 105, wherein the compound is hydrogen, or a pharmaceutically acceptable salt thereof.

107. R ７ , R ８ , R ９ , and R １０ A compound according to any one of claims 1 to 90, wherein the compound is hydrogen, or a pharmaceutically acceptable salt thereof.

108. R １２ａ and R １２ｂ However, each is independent of hydrogen, halogen, and (C １ ~C ６ ) alkyl, (C １ ~C ６ ) is an alkoxy, and here, (C １ ~C ６ The alkyl group is optionally substituted with one, two, or three halogens, and m is 0, the compound according to any one of claims 1, 6 to 13, or 23 to 107, or a pharmaceutically acceptable salt thereof.

109. R １２ａ and R １２ｂ However, together with the carbon atoms to which they are bonded, they are optionally substituted with 5- to 7-membered heterocycloalkyl groups or optionally substituted with (C ５ ~C ７ A compound according to any one of claims 1, 6 to 13, or 23 to 107, or a pharmaceutically acceptable salt thereof, wherein it forms a cycloalkyl group and m is 0.

110. R ａ is fluoro, R ｂ A compound according to any one of claims 1, 6 to 13, or 23 to 109, wherein is hydrogen, or a pharmaceutically acceptable salt thereof.

111. R ａ is hydrogen, R ｂ A compound according to any one of claims 1, 6 to 13, or 23 to 110, wherein the compound is fluoro, or a pharmaceutically acceptable salt thereof.

112. Equation (VI): 【Chemistry 43】 It has, During the ceremony, R １５ａ It is fluoro, p is 0, 1, or 2. Z １ CR １５ｂ or N, R １５ｂ is hydrogen, fluoro, methyl, or methoxy, R １６ is hydrogen or methyl, Z ２ is CH or N, R １７ It is fluoro or methyl, q is 0, 1, or 2. R １２ is fluoro, methyl, ethyl, or methoxy, m is 1, or R １２ is hydrogen, m is 0, R ７ , R ８ , R ９ , and R １０ These are independently hydrogen, fluoro, chloro, methyl, and -CF ３ A compound according to any one of claims 2, 6 to 10, 64, or 65, which is cyclopropyl, methoxy, or cyano, or a pharmaceutically acceptable salt thereof.

113. Formula (VII): 【Chemistry 44】 It has, During the ceremony, R １５ａ It is fluoro, p is 0, 1, or 2. Z １ CR １５ｂ or N, R １５ｂ is hydrogen, fluoro, methyl, or methoxy, R １６ is hydrogen or methyl, Z ２ is CH or N, R １７ It is fluoro or methyl, q is 0, 1, or 2. R １２ is fluoro, methyl, ethyl, or methoxy, m is 1, or R １２ is hydrogen, m is 0, R ７ , R ８ , R ９ , and R １０ These are independently hydrogen, fluoro, chloro, methyl, and -CF ３ A compound according to any one of claims 2, 6 to 10, 64, or 65, which is cyclopropyl, methoxy, or cyano, or a pharmaceutically acceptable salt thereof.

114. Equation (XIII): 【Chemistry 45】 It has, During the ceremony, R ７ , R ８ , R ９ , and R １０ These are independently hydrogen or methyl, R １２ａ and R １２ｂ These are independently hydrogen or methyl, R １５ａ It is fluoro, p is 0, 1, or 2. Z １ CR １５ｂ or N, R １５ｂ is hydrogen or fluoro, Z ２ is CH or N, R １７ It is fluoro, The compound according to any one of claims 3, 64, or 65, a pharmaceutically acceptable salt thereof, and / or stereoisomer, wherein q is 0, 1, or 2.

115. Formula (XIV): 【Chemistry 46】 It has, During the ceremony, R ７ , R ８ , R ９ , and R １０ These are independently hydrogen or methyl, R １２ａ and R １２ｂ These are independently hydrogen or methyl, R １５ａ It is fluoro, p is 0, 1, or 2. Z １ CR １５ｂ or N, R １５ｂ is hydrogen or fluoro, Z ２ is CH or N, R １７ It is fluoro, The compound according to any one of claims 3, 64, or 65, or a pharmaceutically acceptable salt thereof, wherein q is 0, 1, or 2.

116. Formula (XV): 【Chemistry 47】 It has, During the ceremony, R ａ and R ｂ These are independently hydrogen or fluoro, R ７ , R ８ , R ９ , and R １０ These are independently hydrogen or methyl, R １２ａ and R １２ｂ These are independently hydrogen or methyl, or R １２ａ and R １２ｂ These, together with the carbon atoms to which they are bonded, form a five-membered heterocycloalkyl group. Z ３ is CH or N, Z ４ CR １５ｂ or N, R １５ｂ is hydrogen or fluoro, Z ５ The compound according to any one of claims 1, 64, or 65, wherein is CH or N, or a pharmaceutically acceptable salt thereof.

117. R １２ａ and R １２ｂ The compound according to claim 16, or a pharmaceutically acceptable salt thereof, wherein the compound is independently hydrogen or methyl.

118. Formula (XVI): 【Chemistry 48】 A compound according to claim 16, or a pharmaceutically acceptable salt thereof, having the above.

119. The following compounds: (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(3-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-methyl-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-ethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4,6-difluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (S ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)pyrrolidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)pyrrolidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-3-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(3-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-cyclobutyl-1H-pyrrolo[3,2-b]pyridin-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-cyclopropylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-chlorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rac-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-chlorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(3-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-methyl-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-cyclopropylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-2-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-5-(4-((4-(3-cyclopropyl-5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-1H-pyrrolo[2,3-b]pyridin-1-yl)piperidine-1-yl)methyl)-4-fluoropiperidine-1-carbonyl)benzonitrile, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-(trifluoromethyl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-(trifluoromethyl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-fluorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methoxybenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-5-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(3-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-cyclobutyl-1H-pyrrolo[3,2-b]pyridin-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(3-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-cyclobutyl-7-fluoro-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine 2,4(1H,3H)-dione, (R)-1-(3-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-methyl-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(3-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-cyclobutyl-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (S)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (S)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(3-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-cyclobutyl-7-fluoro-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (S)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-isopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(3-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-cyclobutyl-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rac-1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rac-1-(1-(1-((1-(4-((3R,5S)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3,4-dimethyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((R)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-methoxypiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((R)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-methylpiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)-3,5-dimethylpiperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rac-1-(1-(1-((1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)-3,5-dimethylpiperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3,5-difluorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,3s,5S)-8-((1-(4-((R)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)-8-azabicyclo[3.2.1]octane-3-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,3s,5S)-8-((1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-((1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)piperidine-4-yl)methyl)azetidine-3-yl)methyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(-1-(1-(4-((R)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)ethyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4,6-difluoro-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3-fluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(3-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-cyclobutyl-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((3R,4R)-1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-3-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(3-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1,2-dimethyl-1H-indole-7-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,5-difluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-chlorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((S ＊ )-1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(-1-((1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4S ＊ ,5R)-1-((1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidin-4-yl)methyl)-3,5-dimethylpiperidin-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-methoxypiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rel-(R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-2-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, rel-1-(1-((1R,4r)-4-((4-(4-((R)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S ＊ )-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholin-2-yl)benzoyl)piperidin-4-yl)methyl)-3,3-difluoropiperidin-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S ＊ )-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S ＊ )-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((R)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, and (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, A compound according to claim 1, or a pharmaceutically acceptable salt thereof, selected from one or more of the following.

120. The following compounds: (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rac-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-chlorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine 2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (S)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rac-1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rac-1-(1-(1-((1-(4-((3R,5S)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3,4-dimethyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((3R,4R)-1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-3-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,5-difluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-chlorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R ＊ ,4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidin-3-yl)benzoyl)-4-fluoropiperidin-4-yl)methyl)piperidin-4-yl)-3-cyclopropyl-1H-indol-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((S ＊ )-1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(-1-((1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((R ＊ )-1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-3,3-difluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4S ＊ ,5R)-1-((1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)-3,5-dimethylpiperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-methoxypiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S ＊ )-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S ＊ )-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S ＊ )-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((R)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-ethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4,6-difluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-3-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-cyclopropylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-chlorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-cyclopropylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-2-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-5-(4-((4-(3-cyclopropyl-5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-1H-pyrrolo[2,3-b]pyridin-1-yl)piperidine-1-yl)methyl)-4-fluoropiperidine-1-carbonyl)benzonitrile, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-(trifluoromethyl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-(trifluoromethyl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-fluorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methoxybenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-isopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((R)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-methoxypiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((R)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-methylpiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)-3,5-dimethylpiperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rac-1-(1-(1-((1-(4-((R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)-3,5-dimethylpiperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methylpiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4,4-difluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ ,4R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 4S ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-4-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, rel-(R)-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-2-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, and 1-(1-(1-((1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, A compound according to claim 1, or a pharmaceutically acceptable salt thereof, selected from one or more of the following.

121. The following compounds: 1-(1-((S)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)pyrrolidine-3-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S ＊ ,4R ＊ )-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-3-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(7-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)phenyl)piperidine-4-yl)methyl)-7-azaspiro[3.5]nonane-2-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-fluoro-5-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S)-1-((1-(4-((R) ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)pyrrolidine-3-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S ＊ )-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)azepan-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-chlorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(7-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)phenyl)piperidine-4-yl)methyl)-7-azaspiro[3.5]nonane-2-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((1R,5S,8S)-3-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-3-azabicyclo[3.2.1]octan-8-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-(((1R,5S,8S)-3-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-3-azabicyclo[3.2.1]octan-8-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (S ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-3-fluoropiperidine-3-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-fluorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-fluorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-2-fluorobenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-5-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione 1-(1-((1R,4r)-4-((4-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R) ＊ , 5R ＊ , 6S ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5-dimethylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rac-1-(1-((1R,4r)-4-((4-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5-dimethylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R) ＊ , 5R ＊ , 6S ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, rac-1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-2-methylbenzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S ＊ )-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-2,5-dimethylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,6-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-ethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,6-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,6-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(3-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1-cyclobutyl-7-fluoro-1H-indole-6-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-fluoropiperidine-3-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-4-fluoro-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)-3,3-difluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)phenyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)phenyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((R)-1-((1-(4-((R) ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-3-methylbenzoyl)piperidine-4-yl)methyl)pyrrolidine-3-yl)-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(1-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)-2,3-dimethylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(7-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)phenyl)piperidine-4-yl)methyl)-7-azaspiro[3.5]nonane-2-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S ＊ )-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)azepan-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R) ＊ , 6R ＊ )-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-(fluoromethyl)morpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(7-((1-(4-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholin-2-yl)phenyl)piperidine-4-yl)methyl)-7-azaspiro[3.5]nonane-2-yl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R)-1-(1-(1-(1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)benzyl)-4-fluoropiperidine-4-carbonyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((S ＊ )-1'-(4-((R)-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)-3-methylbenzoyl)-[1,3'-bipiperidine]-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(7-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)phenyl)piperidine-4-yl)methyl)-7-azaspiro[3.5]nonane-2-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, (R ＊ )-1-(1-(7-((1-(4-(1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperidine-3-yl)phenyl)piperidine-4-yl)methyl)-7-azaspiro[3.5]nonane-2-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, and 1-(1-(1-((1-(4-((2S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, A compound according to claim 1, or a pharmaceutically acceptable salt thereof, selected from one or more of the following.

122. The following compounds: 1-(1-((3S,4R)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4R)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperazine-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4R)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4S)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4R)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4R)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4S)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4s)-4-((4-(4-(R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4s)-4-((4-(4-(S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)morpholine-2-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperazine-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2S,4S,6S)-6-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3,3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2R,4r,6R)-6-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3,3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2S,4s,6S)-6-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3,3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2R,4r,6R)-6-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)spiro[3,3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2S,4S,6S)-6-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)spiro[3,3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2R,4r,6R)-6-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-3-methylbenzoyl)piperazin-1-yl)methyl)spiro[3,3]heptan-2-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (isomer 1) (( ＊ Absolute placement is unconfirmed.) 1-(1-((1R,4r)-4-((4-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (isomer 1) (( ＊ Absolute placement is unconfirmed.) 1-(1-((1S,4s)-4-((4-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (isomer 1) (( ＊ Absolute placement is unconfirmed.) 1-(1-((1S,4s)-4-((4-(4-((3R) ＊ , 5R ＊ )-1-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methoxypiperidine-3-yl)-3-methylbenzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (isomer 1) (( ＊ Absolute placement is unconfirmed.) 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4S)-1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4R)-1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4S)-1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4R)-1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4S)-1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4R)-1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4S)-1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4R)-1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4S)-1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4R)-1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4R)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4S)-1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4R)-1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4R)-1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1R,4r)-4-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-cyclopropyl-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4R)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-methylbenzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4R)-1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4R)-1-((1-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3S,4R)-1-((1-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-methylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)cyclohexyl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-flu[3,4-b][1,4]oxazin-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)2-methyl-1H-indole-4-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)benzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-flu[3,4-b][1,4]oxazin-2-yl)benzoyl)piperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((1S,4s)-4-((4-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)piperazine-1-yl)methyl)cyclohexyl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2S,4s,6S)-6-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)spiro[3,3]heptan-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2R,4r,6R)-6-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)spiro[3,3]heptan-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2-methylbenzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((3R,4S)-1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)-2-methylbenzoyl)piperidine-4-yl)methyl)-3-fluoropiperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)-2,5-dimethylbenzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazine-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazine-1-yl)methyl)-1,3-dioxan-5-yl)-3-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-6-methylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(3-fluoro-2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(3,5-difluoro-2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2R,5R,6S)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-((2r,5R)-2-((4-(4-((2S,5S,6R)-4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)-5,6-dimethylmorpholine-2-yl)benzoyl)piperazin-1-yl)methyl)-1,3-dioxan-5-yl)-3-cyclopropyl-1H-pyrrolo[2,3-b]pyridine-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, 1-(1-(1-((1-(4-((2R,5R)-4-(3-amino-6-(5-fluoro-2-hydroxyphenyl)pyridazin-4-yl)-5-methylmorpholine-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, and 1-(1-(1-((1-(4-((2R,4aR,7aR)-4-(3-amino-6-(5-fluoro-2-hydroxyphenyl)pyridazin-4-yl)hexahydro-2H-fluoro[3,4-b][1,4]oxazin-2-yl)benzoyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)-6-methyl-1H-indole-5-yl)dihydropyrimidine-2,4(1H,3H)-dione, A compound according to claim 1, or a pharmaceutically acceptable salt thereof, selected from one or more of the following.

123. A pharmaceutical composition comprising a compound according to any one of claims 1 to 122, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

124. A method for degrading the SMARCA2 protein in a human, comprising administering to a human in need of such degradation an effective amount of a compound according to any one of claims 1 to 122 or a pharmaceutically acceptable salt thereof, or a composition according to claim 123.

125. A method for reducing the level of SMARCA2 activity in a human, comprising administering to a human in need of such reduction an effective amount of a compound according to any one of claims 1 to 122 or a pharmaceutically acceptable salt thereof, or a composition according to claim 123.

126. A method for treating cancer in a human being, comprising administering to a human being in need of such treatment an effective amount of a compound according to any one of claims 1 to 122 or a pharmaceutically acceptable salt thereof, or a composition according to claim 123.

127. The method according to claim 126, wherein the cancer is a SMARCA2-sensitive cancer.

128. The method according to claim 126, wherein the cancer is a SMARCA2 mutation cancer.

129. The method according to any one of claims 126 to 128, wherein the cancer is a solid tumor.

130. The method according to any one of claims 126 to 128, wherein the cancer is lung cancer, liver cancer, colon cancer, skin cancer, bladder cancer, cervical cancer, or ovarian cancer.

131. A compound according to any one of claims 1 to 122 or a pharmaceutically acceptable salt thereof, or a composition according to claim 123, for use in the degradation of the SMARCA2 protein in humans.

132. A compound according to any one of claims 1 to 122 or a pharmaceutically acceptable salt thereof, or a composition according to claim 123, for use in reducing the level of SMARCA2 activity in humans.

133. A compound according to any one of claims 1 to 122 or a pharmaceutically acceptable salt thereof, or a composition according to claim 123, for use in the treatment of cancer in humans.

134. The compound for use according to claim 133, wherein the cancer is a SMARCA2-sensitive cancer.

135. The compound for use according to claim 133, wherein the cancer is a SMARCA2 mutation cancer.

136. A compound for use according to any one of claims 133 to 135, wherein the cancer is a solid tumor.

137. The compound for use according to any one of claims 133 to 135, wherein the cancer is lung cancer, liver cancer, colon cancer, skin cancer, bladder cancer, cervical cancer, or ovarian cancer.

138. Use of a compound according to any one of claims 1 to 122 or a pharmaceutically acceptable salt thereof, or the composition according to claim 123, in the manufacture of a pharmaceutical product for degrading the SMARCA2 protein in humans.

139. Use of a compound according to any one of claims 1 to 122 or a pharmaceutically acceptable salt thereof, or the composition of claim 123, in the manufacture of a pharmaceutical product for reducing the level of SMARCA2 activity in humans.

140. Use of a compound according to any one of claims 1 to 122 or a pharmaceutically acceptable salt thereof, or a composition according to claim 123, in the manufacture of a pharmaceutical product for treating cancer in humans.

141. A compound for use according to claim 140, or a pharmaceutically acceptable salt thereof, wherein the cancer is a SMARCA2-sensitive cancer.

142. The compound for use according to claim 140, or a pharmaceutically acceptable salt thereof, wherein the cancer is a SMARCA2 mutation cancer.

143. A compound for use according to any one of claims 141 to 143, wherein the cancer is a solid tumor.

144. The compound for use according to any one of claims 141 to 143, wherein the cancer is lung cancer, liver cancer, colon cancer, skin cancer, bladder cancer, cervical cancer, or ovarian cancer.

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