Use of compounds in the treatment of liver disease
Small molecule compounds with immunomodulatory functions, combined with immune checkpoint inhibitors and chemotherapeutic agents, address the limitations of current HCC treatments by enhancing therapeutic efficacy and safety for liver diseases.
JP2026523276APending Publication Date: 2026-07-13BEIJING SYNTHETIC VACCINE BIOSCIENCES CO LTD
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Patent Information
- Application Number
- JP2026501258
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-08-22
- Filing Date
- 2024-08-13
- Publication Date
- 2026-07-13
AI Technical Summary
Technical Problem
Current treatments for advanced hepatocellular carcinoma (HCC) have limited efficacy and cause adverse reactions, with a need for novel targeted immunotherapies to extend survival time and improve the biochemical quality of life for liver cancer patients.
Method used
The use of small molecule compounds with immunomodulatory functions for the prevention and treatment of liver diseases, including liver tumors and hepatitis, in combination with immune checkpoint inhibitors and chemotherapeutic agents.
Benefits of technology
The compounds demonstrate high targeting of liver tissue with low toxicity, improving therapeutic effects against liver diseases such as hepatitis B and liver cancer, and exhibit excellent physicochemical properties, metabolic stability, and safety.
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Abstract
This invention discloses the use of a compound in the treatment of liver diseases. As is evident from experimental results, the compound exhibits high targeting of liver tissue, very low toxicity to primary hepatocytes, high liver safety, and clear therapeutic effects against liver diseases such as viral hepatitis (e.g., hepatitis B) and liver cancer (including primary and metastatic liver cancer). It possesses excellent physicochemical properties, metabolic stability, bioavailability, and safety, and has excellent potential for drug development.
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