Personal care composition

Abstract

The present invention relates to a personal care composition. In particular, the present invention relates to a personal care composition comprising a carboxymethylcysteine ​​compound, one or more oil-soluble sunscreens, and one or more water-soluble sunscreens. The personal care composition provides protection from potentially harmful effects that may be caused by exposure to ultraviolet and visible light, such as blue light.

Description

[Technical Field]

[0001] This invention relates to personal care compositions. In particular, this invention relates to personal care compositions that provide protection from potentially harmful effects that may be caused by exposure to sunlight. [Background technology]

[0002] Sunlight radiation contains approximately 5% ultraviolet (UV) radiation, with wavelengths ranging from 200nm to 400nm. This is further divided into three regions: 320-400nm (UV-A), 280-320nm (UV-B), and 200-280nm (UV-C). A significant portion of UV-C radiation is absorbed by ozone. Scientific studies have shown that short-term exposure to UV-A and UV-B radiation causes pigmentation, skin redness, and local irritation, while continuous or long-term exposure can lead to sunburn, wrinkle formation, and age spots. UV radiation is also thought to cause significant damage to hair. Therefore, it is desirable to protect the skin and other keratinous substrates of the human body from the harmful effects of both UV-A and UV-B radiation.

[0003] This is often achieved through personal care compositions, such as cosmetic compositions, that provide protection from UV-B (measured as sun protection factor, SPF) and / or UV-A (measured as UV-A protection factor, UVAPF). A variety of personal care compositions have been reported to block and / or protect the skin from the harmful effects of UV radiation. Numerous organic sunscreens capable of absorbing UV-A rays have been reported in the field of cosmetics, among which a particularly useful sunscreen is t-butyl methoxydibenzoylmethane (also known as avobenzone and marketed as Parsol® 1789). Various UV-B sunscreens, such as octyl salicylate, have been used in personal care compositions for protection from UV-B radiation. Many cosmetic manufacturers prefer to include UV-B as well as UV-A sunscreens in their photoprotective compositions to provide protection across the full range of UV radiation.

[0004] On the other hand, solar radiation also includes visible spectral wavelengths from 380 nm to 700 nm, including blue light (approximately 450 nm to 495 nm). Blue light within the visible spectrum has also been reported to cause undesirable effects.

[0005] Thus, exposure to sunlight tends to cause the generation of reactive oxygen species (ROS), which can lead to potentially harmful effects such as oxidative stress, hyperpigmentation, age spots, wrinkles, and sunspots. One way to reduce such potentially harmful effects is to avoid exposure to sunlight. However, in many cases, this is unavoidable, and people tend to be exposed to sunlight through their daily activities.

[0006] Therefore, consumers tend to rely on personal care compositions that protect their skin from such potentially harmful effects that can be caused by exposure to sunlight. Thus, consumers tend to expect such compositions to provide protection from such sun-induced damage / potentially harmful effects, such as the generation of ROS. Consumers also tend to expect such compositions to deliver such benefits to an improved degree. [Overview of the project] [Problems that the invention aims to solve]

[0007] Therefore, there is a need to develop personal care compositions that meet consumer expectations and provide protection from sun damage. There is also a need to provide personal care compositions that provide such benefits to an improved degree by using active or beneficial agents in combination with sunscreens, i.e., personal care compositions that provide improved protection from sun damage.

[0008] Currently, it has been found that combining carboxymethylcysteine ​​compounds with oil-soluble and water-soluble sunscreens provides improved protection from sun-induced damage, such as the generation of reactive oxygen species (ROS). In particular, the combination of carboxymethylcysteine ​​compounds with oil-soluble and water-soluble sunscreens has been found to provide improved protection from ROS, i.e., a reduction in ROS generation, thereby reducing oxidative stress. Therefore, new applications for carboxymethylcysteine ​​compounds as antioxidants have also been discovered. Furthermore, carboxymethylcysteine ​​compounds have been found to increase SPF when used in combination with oil-soluble and water-soluble sunscreens. [Means for solving the problem]

[0009] Therefore, in a first aspect, the present invention relates to personal care compositions and includes the following:

[0010] a. Carboxymethylcysteine ​​compounds selected from carboxymethylcysteine, carboxymethylcysteine ​​esters, carboxymethylcysteine ​​amides, carboxymethylcysteine ​​salts, and mixtures thereof. b. One or more oil-soluble sunscreens in an amount of 0.1-15 wt%, and c. One or more water-soluble sunscreens in an amount of 0.1 to 10 wt%.

[0011] In a second embodiment, the present invention relates to a method for providing a surface with protection from sun-induced damage, and includes the following:

[0012] a. A step of applying the composition of the first embodiment to a surface, and b. A step of rinsing the surface may be included.

[0013] In a third aspect, the present invention relates to the use of the composition of the first aspect for providing protection from sun-induced damage.

[0014] In a fourth embodiment, the present invention relates to the use of the composition of the first embodiment to provide protection from UV-induced damage.

[0015] In a fifth aspect, the present invention relates to the use of carboxymethylcysteine ​​compounds in providing protection from damage caused by visible light.

[0016] The present invention is described in further detail as follows. [Modes for carrying out the invention]

[0017] Any feature of one aspect of the present invention may be utilized in any other aspect of the present invention. The word “comprising” is intended to mean “including,” but not necessarily “consisting of” or “composed of.” In other words, the listed steps or options do not need to be exhaustive. Except for the examples of operations and comparative examples, or unless otherwise expressly indicated, all figures herein indicating the amount or conditions of a material or reaction, the physical properties of a material and / or use should be understood to be modified by the word “about.” Numerical ranges expressed in the form “x to y” are understood to include x and y. If multiple preferred ranges are described in the form “x to y” for a particular feature, it should be understood that all ranges combining different endpoints are also intended. Unless otherwise specified, amounts used herein are expressed as weight percentages based on the total weight of the composition and may be abbreviated as “wt%.” The use of any example or illustrative language provided herein, e.g., “etc.”, is intended solely to better illustrate the present invention and in no way to limit the scope of the present invention as otherwise claimed.

[0018] Except as an example or unless otherwise expressly indicated, all figures herein indicating the quantity or reaction conditions of materials, the physical properties of materials and / or use may be understood to be modified by the word “approximately”.

[0019] The composition of the present invention is intended for use in personal care or cosmetic applications and may also be referred to as a personal light protection composition. As used herein, "personal care composition" means a composition for topical application to sun-exposed areas of human skin and / or hair. Such compositions can be classified as leave-on or rinse-off and include any product applied to the human body to improve appearance, cleansing, odor control or general aesthetics. The composition of the present invention can be in the form of a liquid, lotion, cream, foam, stick or gel. Non-limiting examples of such compositions include leave-on skin lotions, creams, antiperspirants, deodorants, foundations, mascaras, sunscreen lotions and wash-off shampoos, conditioners and shower gels. The composition of the present invention is preferably a leave-on composition.

[0020] As used herein, "skin" preferably means skin on any part of the body, such as the face, neck, chest, back, arms, underarms, hands, legs, buttocks and scalp, particularly the sun-exposed portions thereof. The composition of the present invention is also related to the application to any other keratinous substrate of the human body other than the skin, such as hair, and products can be formulated particularly for the purpose of improving light protection.

[0021] Preferably, the phrase "damage caused by the sun" means damage or harmful or potentially harmful effects that can be caused by exposure to sunlight. Similarly, the phrase "damage caused by UV" preferably means damage or harmful or potentially harmful effects that can be caused by exposure to UV. Further, the phrase "damage caused by visible light" preferably means damage or harmful or potentially harmful effects that can be caused by exposure to visible light, such as blue light.

[0022] In a first aspect, a personal care composition (composition) according to the present invention comprises the following.

[0023] a. A carboxymethylcysteine compound selected from carboxymethylcysteine, esters of carboxymethylcysteine, amides of carboxymethylcysteine, salts of carboxymethylcysteine, and mixtures thereof. b. One or more oil-soluble sunscreens in an amount of 0.1 to 15 wt%, and c. One or more water-soluble sunscreens in an amount of 0.1 to 10 wt%.

[0024] Carboxymethylcysteine compound The composition contains a carboxymethylcysteine compound.

[0025] The carboxymethylcysteine compound refers to a compound selected from carboxymethylcysteine, salts of carboxymethylcysteine, esters of carboxymethylcysteine, amides of carboxymethylcysteine or mixtures thereof.

[0026] Preferably, the carboxymethylcysteine compound contains carboxymethylcysteine, such as S-carboxymethyl-L-cysteine, esters of carboxymethylcysteine, and / or salts of carboxymethylcysteine. More preferably, the carboxymethylcysteine compound contains carboxymethylcysteine and / or salts of carboxymethylcysteine. Even more preferably, the carboxymethylcysteine compound contains salts of carboxymethylcysteine, such as L-lysine (1:1) combined with S-(carboxymethyl)-L-cysteine (LCC, CAS registration number 49673-81-6, also known as carboxymethylcysteine lysine). Most preferably, the carboxymethylcysteine compound is LCC.

[0027] Preferably, the carboxymethylcysteine compound is present in an amount of 0.00001 wt% to 10 wt%, more preferably 0.0001 wt% to 8 wt%, even more preferably 0.001 wt% to 5 wt%, still even more preferably 0.01% to 3 wt%, and most preferably 0.1 wt% to 1 wt%.

[0028] Preferably, the carboxymethylcysteine ​​compound is present in an amount of 10 wt% or less, more preferably 5 wt% or less, even more preferably 3 wt% or less, even more preferably 1 wt% or less, and most preferably 0.5 wt% or less. Preferably, LCC is present in an amount of at least 0.00001 wt%, more preferably at least 0.0001 wt%, even more preferably at least 0.001 wt%, even more preferably at least 0.01 wt%, and most preferably at least 0.1 wt%.

[0029] Oil-soluble sunscreen The composition contains one or more oil-soluble sunscreens.

[0030] Preferably, one or more oil-soluble sunscreens are selected from UV-A oil-soluble sunscreens selected from dibenzoylmethane compounds, diethylaminohydroxybenzoyl hexyl benzoate (commercially available as Uvinul® A Plus), and menthyl anthranilate, and / or UV-B oil-soluble sunscreens selected from octyl salicylate, 3,3,5-trimethylchlorohexyl 2-hydroxybenzoate, ethylhexyl salicylate, 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate, 2-ethylhexyl-4-methoxycinnamate, and octyl methoxycinnamate.

[0031] If one or more oil-soluble sunscreens are selected from dibenzoylmethane compounds, they are preferably selected from 2-methyldibenzoylmethane, 4-isopropyldibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane (commercially available as Parsol® 1789 or avobenzone), 2,4-dimethyldibenzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4'-diisopropyldibenzoylmethane, 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane, 2-methyl-5-tert-butyl-4'-methoxy-5dibenzoylmethane, 2,4-dimethyl-4'-methoxydibenzoylmethane, 2,6-dimethyl-4-tert-butyl-4'-methoxydibenzoylmethane, and mixtures thereof. When one or more oil-soluble sunscreens are selected from dibenzoylmethane compounds, 4-tert-butyl-4'-methoxydibenzoylmethane (commercially available as Parsol® 1789 or avobenzone) is more preferably used as the dibenzoylmethane compound.

[0032] The composition contains one or more of the above oil-soluble sunscreens in an amount of 0.1 to 15 wt%, preferably 1 to 13 wt%, preferably 2 to 10 wt%, preferably 3 to 8 wt%, and preferably 4 to 6 wt%.

[0033] In the context of oil-soluble sunscreens, "oil-soluble" means that, for both UV-A and UV-B sunscreens, the solubility of the sunscreen in water is preferably less than 10 g / L, more preferably less than 5 g / L, and more preferably less than 2 g / L at 25°C.

[0034] Water-soluble sunscreen The composition comprises one or more water-soluble sunscreens. Preferably, one or more water-soluble sunscreens are selected from UV-B water-soluble sunscreens selected from phenylbenzimidazole sulfonic acid, benzylidene camphor sulfonic acid, and benzophenone-4, and / or UV-A water-soluble sunscreens selected from phenyldibenzimimidazole tetrasulfonate disodium, terephthalylidene dicamphor sulfonic acid, and mixtures thereof. For the purposes of the present invention, benzylidene camphor sulfonic acid and benzophenone-4 are considered UV-B sunscreens.

[0035] The composition contains one or more of the above water-soluble sunscreens in an amount of 0.1 to 10 wt%, preferably 1 to 8 wt%, preferably 2 to 6 wt%, and preferably 3 to 5 wt%.

[0036] In the context of water-soluble sunscreens, "water-soluble" means that, for both UV-A and UV-B sunscreens, the solubility of the sunscreen in water at 25°C is preferably higher than 10 g / L, and more preferably higher than 50 g / L.

[0037] Inorganic sunscreen The composition may further preferably contain an inorganic sunscreen selected from titanium dioxide (TiO2), zinc oxide (ZnO), and mixtures thereof.

[0038] Preferably, the composition contains such inorganic sunscreens in an amount of 0.1 to 25 wt%, more preferably 1 to 22 wt%, even more preferably 3 to 20 wt%, even more preferably 5 to 15 wt%, even more preferably 7 to 12 wt%, and even more preferably 9 to 11 wt%.

[0039] surfactant Preferably, the composition is in the form of an emulsion. It may be an oil-in-water (o / w) emulsion or a water-in-oil (w / o) emulsion. Preferably, it is in the form of an oil-in-water emulsion. For this purpose, the composition preferably comprises one or more surfactants / emulsifiers. Preferably, one or more surfactants / emulsifiers are selected from anionic surfactants, nonionic surfactants, amphoteric surfactants and mixtures thereof, of which nonionic surfactants are particularly preferred.

[0040] Preferably, if one or more surfactants are selected from anionic surfactants, they may be alkyl ether sulfates and sulfonates, alkyl sulfates and sulfonates, alkylbenzene sulfonates, alkyl and dialkyl sulfosuccinates, C8-C 20 Asyl isethionate, C8-C 20 Alkyl ether phosphates, alkyl ether carboxylates, and combinations thereof may be selected.

[0041] More preferably, one or more surfactants are selected from nonionic surfactants having HLB values ​​in the range of 9 to 20, preferably 10 to 19, more preferably 12 to 18, even more preferably 13 to 17, and even more preferably 15 to 17.

[0042] HLB is calculated using the Griffin method, where HLB = 20 × Mh / M, where Mh is the molecular weight of the hydrophilic portion of the molecule and M is the molecular weight of the entire molecule, giving results from 0 to 20 on an arbitrary scale. Typical values ​​for various surfactants are shown below.

[0043] Value < 10, lipid-soluble (water-insoluble) Value > 10, water-soluble Values ​​between 4 and 8 indicate the presence of an antifoaming agent. Values ​​7-11 indicate W / O (water-in-oil) emulsifiers. Values ​​between 12 and 16 indicate oil-in-water emulsifiers. The values ​​11-14 indicate the wetting agent. Values ​​between 12 and 15 are typical for detergents. Values ​​between 16 and 20 indicate a solubilizer or hydrotrope.

[0044] Preferably, one or more nonionic surfactants having an HLB value in the range of 9 to 20 are selected from fatty alcohol ethoxylates, fatty acid ethoxylates, alkylphenol ethoxylates, polyoxyethylene sorbitan alkyl esters, and mixtures thereof.

[0045] Examples of fatty alcohol ethoxylates that can be used as nonionic surfactants in compositions include polyoxyethylene lauryl ether (HLB=16.9, commercially available as Brij® 35), polyoxyethylene (20) cetyl ether (HLB=16, commercially available as Brij® 58), polyethylene glycol octadecyl ether (HLB=18.8, commercially available as Brij® 700), and laureth-9 (C12EO9, HLB=14.3, commercially available as Brij® L9).

[0046] Examples of alkylphenol ethoxylates that can be used as nonionic surfactants in a composition include octylphenol ethoxylate (HLB=15.5, marketed as Triton® X165), octylphenol ethoxylate (HLB=17.6, marketed as Triton® X405), and octylphenol ethoxylate (HLB=18.4, marketed as Triton® X705).

[0047] Examples of polyoxyethylene sorbitan alkyl esters that can be used as nonionic surfactants in compositions include polyoxyethylene sorbitan monolaurate (HLB=13.3, commercially available as Tween® 21), polyoxyethylene sorbitan monolaurate (HLB=16.7, commercially available as Tween® 20), polyoxyethylene sorbitan monopalmitate (HLB=15.6, commercially available as Tween® 40), and polyoxyethylene sorbitan monostearate (HLB=14.9, commercially available as Tween® 60).

[0048] More preferably, the nonionic surfactant having an HLB value in the range of 9 to 20 that may be present in the composition is a fatty alcohol ethoxylate having a saturated carbon chain and having an HLB higher than 15.5.

[0049] Preferably, if one or more surfactants are selected from amphoteric surfactants, it is cocamidopropyl betaine, C 12 -C 20 Trialkylbetaine, sodium lauroamphoacetate, sodium laurodiamphoacetate, and mixtures thereof may be selected.

[0050] Preferably, the composition contains one or more of the above surfactants in an amount of 0.1 to 30 wt%, more preferably 0.5 to 25 wt%, even more preferably 1 to 20 wt%, even more preferably 2 to 15 wt%, even more preferably 3 to 10 wt%, and even more preferably 5 to 7 wt%.

[0051] Other emulsifiers Preferably, the composition contains an emulsifier. Examples of such emulsifiers include glyceryl stearate, glycol stearate, stearamide AMP, PEG-100 stearate (HLB=18.8), cetyl alcohol, and emulsifying / thickening additives such as hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer / squalene and mixtures thereof. If present, such emulsifiers may be present in an amount of preferably 0.1-5 wt%, more preferably 0.5-4 wt%, and even more preferably 1-3 wt%.

[0052] Moisturizer Preferably, the composition further comprises one or more humectants selected from butylene glycol, hyaluronic acid, pentylene glycol, propanediol, 1,2,6-hexanetriol, 1,3-butylene glycol, dipropylene glycol, ethoxylated glycerol, propoxylated glycerol, glycerol, hexylene glycol, hydroxypropyl sorbitol, isoprene glycol, polyethylene glycol, polypropylene glycol, propylene glycol, and sorbitol.

[0053] More preferably, the humectant is selected from glycerol, pentylene glycol, butylene glycol, and mixtures thereof.

[0054] Preferably, the composition contains one or more of the above humectants in an amount of 0.1 to 20 wt%, more preferably 1 to 18 wt%, even more preferably 3 to 15 wt%, even more preferably 5 to 12 wt%, and even more preferably 7 to 10 wt%.

[0055] fatty acid Preferably, the composition further comprises fatty acids. When fatty acids are present in the composition together with soap, they provide a so-called vanishing cream effect, that is, when the composition is applied to human skin, it disappears from the skin without leaving any noticeable streaks of the composition.

[0056] The composition preferably contains a fatty acid having carbon atoms in the range of 8 to 22, more preferably 10 to 22, even more preferably 12 to 22, even more preferably 14 to 22, even more preferably 16 to 22, and even more preferably 18 to 22. Examples of fatty acids that can be used in the composition include lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, arachidic acid, behenic acid, erucic acid, and mixtures thereof. Preferably, the fatty acid is selected from stearic acid, palmitic acid, and mixtures thereof. The fatty acid in the present invention is preferably hystric acid, which is substantially (generally about 90 to 95%) a mixture of stearic acid and palmitic acid, with the amount of palmitic acid being in the range of 40 to 65% and the amount of stearic acid being in the range of 34 to 58%.

[0057] Preferably, the composition contains 3 to 25 wt%, more preferably 4 to 22 wt%, even more preferably 7 to 20 wt%, even more preferably 10 to 19 wt%, and even more preferably 12 to 18 wt% of fatty acids.

[0058] Preferably, the composition further comprises soap. When the soap is present in combination with fatty acids in the composition, it provides a so-called vanishing effect.

[0059] soap The soaps of the present invention are generally prepared by in-situ neutralization of fatty acids present in the composition. Therefore, it is preferable that the soaps have carbon chain lengths corresponding to the chain lengths of the fatty acids that may be present in the composition. The soaps are formed from fatty acids by the use of alkali metal hydroxides, such as sodium hydroxide and potassium hydroxide.

[0060] The composition contains 0.1 to 10 wt%, preferably 1 to 8 wt%, more preferably 2 to 7 wt%, even more preferably 2 to 6 wt%, even more preferably 2 to 5 wt%, and most preferably 2 to 4 wt% soap.

[0061] polymer Preferably, the composition further comprises 0.25 to 5 wt%, preferably 0.5 to 4 wt%, preferably 1 to 3 wt%, for example 2 wt%, of a polymer selected from dimethicone / vinyl dimethicone crosspolymer polymers that contain or do not contain silica. Various types of polymers of the above kinds can be used in the present invention to improve the sensory properties of the composition. Preferred dimethicone / vinyl dimethicone crosspolymers according to the present invention are available as KM-9729, DOWSIL® EP-9215, SeraSnow SP 13, DOWSIL® 9506 Powder, and Specsil SPD. A more preferred polymer according to the present invention is dimethicone / vinyl dimethicone crosspolymer (and) silica, available as DOWSIL® 9701 Cosmetic Powder.

[0062] Other suitable examples of such polymers that may be used are as follows:

[0063] - Available as DOWSIL (trademark) EP-9801 Hydro Cosmetic Powder, Dimethicone / Vinyl Dimethicone Crosspolymer (and) Silica (and) Butylene Glycol - Available as DOWSIL (trademark) 9576 Smooth Away Elastomer, dimethicone (and) dimethicone / vinyl dimethicone crosspolymer (and) dimethicone crosspolymer (and) beeswax (and) silica (and) silylated silica, - Dimethicone / vinyl dimethicone crosspolymer (and) polymethylsilsesquioxane (and) dimethylsilylated silica, available as SSP100. - Dimethicone / vinyl dimethicone crosspolymer (and) lauroyl lysine, available as DOWSIL (trademark) EP-9289 LL. -The hydrophobic modified silica is preferably selected from silylated silica available as DOWSIL(trademark) VM-2270 AerogelFine Particles, HDK(registered trademark) H2000, and -Dimethylsilylated silica available as HDK(registered trademark)H15, HDK(registered trademark)H20, HDK(registered trademark)H30, and HDK(registered trademark)H18.

[0064] pH of the composition Preferably, the pH of the composition is in the range of 5.0 to 8.0, more preferably 5.5 to 7.5, and even more preferably 6.0 to 7.0. If necessary, the pH of the composition may be adjusted using known pH adjusters, such as sodium hydroxide, potassium hydroxide, and hydrochloric acid.

[0065] Silicone oil If the composition is in the form of a silicone oil-in-water emulsion, the composition preferably contains dimethicone, also known as polydimethylsiloxane (PDMS). Examples of PDMS include dimethicone 10cSt (commercially available as DC-200 Dimethicone 10cSt) and dimethicone 50cSt (commercially available as DC-200 Dimethicone 50cSt). Silicone oils are known to provide a smooth feel to the surface to which they are applied.

[0066] water Preferably, the composition contains water. Water may be present in the composition in an amount of 5 to 99.9 wt%, more preferably 10 to 95 wt%, even more preferably 15 to 90 wt%, even more preferably 20 to 80 wt%, even more preferably 25 to 75 wt%, and even more preferably 30 to 70 wt%.

[0067] Other polymers Preferably, the composition further comprises polymers other than those mentioned above. These polymers act as thickeners in the composition. These polymers are preferably selected from the following classifications.

[0068] -Acrylate / R-methacrylate copolymers, for example, acrylate / steareth-20 methacrylate copolymer (marketed as Aculyn® 22) and acrylate / beheneth-25 methacrylate copolymer (marketed as Aculyn® 28), -Acrylate / R-methacrylate crosspolymer, e.g., acrylate / steareth-20 methacrylate crosspolymer (marketed as Aculyn(trademark) 88), -Acrylate copolymer (marketed as Aculyn(trademark) 33), -Acrylate / R-alkylacrylate crosspolymer, for example, acrylate / alkyl acrylate (C10-C30) crosspolymer (commercially available as Pemulen® TR-2), - Ammonium acryloyldimethyltaurate copolymer and vinylpyrrolidone (marketed as Aristoflex® AVC), -A copolymer of sodium acryloyldimethyltaurate and vinylpyrrolidone (marketed as Aristoflex® AVS), and - Crosspolymers of acryloyldimethyltaurate with R-alkylacrylates and methacrylates, e.g., ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer (commercially available as Aristoflex® HMB and Aristoflex® BLV), and mixtures thereof.

[0069] More preferably, the polymer is selected from acrylate / R-methacrylate copolymers, acrylate copolymers, and mixtures thereof.

[0070] Preferably, the composition contains 0.1 to 5 wt%, more preferably 0.5 to 4.5 wt%, even more preferably 1 to 4 wt%, even more preferably 1.5 to 3.5 wt%, and even more preferably 2 to 3 wt% of these other polymers.

[0071] Skin whitening agent Preferably, the composition further comprises one or more skin whitening agents. These one or more skin whitening agents include niacinamide, vitamin B6, vitamin C, vitamin A, glutathione precursor, galarzin, adapalene, aloe extract, ammonium lactate, arbutin, azelaic acid, butylhydroxyanisole, butylhydroxytoluene, citrate ester, deoxyarbutin, 1,3-diphenylpropane derivative, 2,5-dihydroxybenzoic acid and its derivatives, 2-(4-acetoxyphenyl)-1,3-dithiane, 2-(4-hydroxyphenyl)-1,3-dithiane, ellagic acid, glucopyranosyl-1-ascorbate, and gluconate. Acids, glycolic acid, green tea extract, 4-hydroxy-5-methyl-3[2H]-furanone, 4-hydroxyanisole and its derivatives, 4-hydroxybenzoic acid derivatives, hydroxycaprylic acid, inositol ascorbate, lactic acid, linoleic acid, magnesium ascorbyl phosphate, 5-octanoylsalicylic acid, salicylic acid, 3,4,5-trihydroxybenzyl derivatives, acetylglucosamine, Pitera extract, Symwhite, calcium pantothenate (Melano-block), seppiwhite, 12-hydroxystearic acid, and mixtures thereof may be selected. When used in a composition, 12-hydroxystearic acid is used as a skin whitening agent and not as a fatty acid. Preferably, skin whitening agents that can be used in a composition are niacinamide, vitamin B6, 12-hydroxystearic acid, and mixtures thereof.

[0072] When incorporated into a composition, a skin whitening agent may be added to the composition in an amount of 0.001 to 15 wt%, preferably 0.01 to 10 wt%, more preferably 0.1 to 5 wt%, and even more preferably 0.5 to 3 wt%.

[0073] Skin softener Preferably, the composition further comprises an emollient. Examples of emollients that may be used in the composition include stearyl alcohol, glyceryl monolicinolate, mink oil, cetyl alcohol, isopropyl isostearate, isobutyl palmitate, isocetyl stearate, oleyl alcohol, isopropyl laurate, hexyl laurate, decyl oleate, octadecane-2-ol, isocetyl alcohol, eicosanyl alcohol, behenyl alcohol, cetyl palmitate, silicone oil, such as dimethylpolysiloxane, din-butyl sebacate, isopropyl myristate, palmitate This includes isopropyl acid, isopropyl stearate, butyl stearate, polyethylene glycol, triethylene glycol, lanolin, cocoa butter, corn oil, cottonseed oil, olive oil, palm kernel oil, rapeseed oil, safflower seed oil, evening primrose oil, soybean oil, sunflower seed oil, avocado oil, sesame seed oil, coconut oil, peanut oil, castor oil, acetylated lanolin alcohol, petrolatum, mineral oil, butyl myristate, isopropyl linoleate, lauryl lactate, myristyl lactate, decyl oleate, myristyl myristate, and mixtures thereof.

[0074] solvent Preferably, the composition further comprises a solvent. Examples of solvents that may be used in the composition include ethyl alcohol, isopropanol, ethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, and mixtures thereof. Preferably, such a solvent may be present in an amount of 1 to 10 wt%, more preferably 3 to 5 wt%.

[0075] Preservatives Preferably, the composition further comprises preservatives to protect against the growth of potentially harmful microorganisms. Examples of components that can be used as preservatives in the composition include alkyl esters of para-hydroxybenzoic acid, hydantoin derivatives, propionates, and various quaternary ammonium compounds. More preferably, components that can be used as preservatives in the composition include sodium benzoate, iodopropynyl butylcarbamate, methylisothiazolinone, iodopropynyl butylcarbamate, phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, sodium dehydroacetate, ethylhexylglycerin, benzyl alcohol, alkanediols, and mixtures thereof. Alkanediols suitable for use as preservatives are C6-C6 substituted adjacently with hydroxyl groups. 12 These are alkanes. Examples for illustrative purposes include 1,2-octanediol (caprylyl glycol), 2,3-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-hexanediol, 3,4-octanediol, and mixtures thereof, with caprylyl glycol being the most preferred. When present in the composition, preservatives are added in an amount of preferably 0.001 to 5 wt%, more preferably 0.01 to 3 wt%, and most preferably 0.02 to 2 wt%.

[0076] Other optional components The composition may further contain a range of other optional ingredients, including antioxidants, binders, buffers, colorants, astringents, fragrances, emulsions, conditioners, exfoliants, skin soothing agents, and skin healing agents.

[0077] Product form The composition can be formulated in the form of a cream, lotion, serum, mousse, spray, or stick. Preferably, the composition is in the form of a cream.

[0078] In a second embodiment, the present invention relates to a method for providing a surface with protection from damage caused by the sun, and includes the following:

[0079] a. A step of applying the composition of the first embodiment to a surface, and b. A step of rinsing the surface may be included.

[0080] In step a, the composition of the first embodiment is applied to a surface, for example, skin. This step may be carried out so that the consumer applies an appropriate amount of the composition, for example 2 grams, or, in the case of a liquid product, for example 5 mL, to the surface. The step of applying the composition may be carried out using hands, or using an applicator, for example a spatula and a sponge. The composition thus applied is spread over the area to form a layer of appropriate thickness.

[0081] The method of the present invention may include a further step of rinsing the surface to which the composition was applied in the preceding step, step a, with water. In other words, the surface is washed with water while simultaneously removing the thus applied composition. Step b is an optional step that does not need to be performed when the composition is formulated as a leave-on composition. However, it is an essential step when the composition is formulated as a wash-off composition.

[0082] The term "leave-on composition" preferably refers to a composition that does not need to be removed from the human body after application, such as a cream.

[0083] The term "wash-off" composition preferably means a composition that is intended / required to be removed from the body by washing with a solvent, preferably water, after application, such as hand-washing compositions and facial cleansing compositions. If the composition is formulated in the form of a wash-off composition, step b. is preferably performed within 15 minutes after step a., more preferably within 10 minutes, even more preferably within 5 minutes, even more preferably within 1 minute, for example, within 15 seconds, within 30 seconds. Preferably, the method is essentially non-therapeutic or cosmetic.

[0084] In a third embodiment, the present invention relates to the use of the composition of the first embodiment for providing protection from sun-induced damage. When the composition of the first embodiment is applied to a surface, such as skin, it protects the surface from potentially harmful effects that may be caused by exposure to sunlight. Preferably, the use is essentially non-therapeutic or cosmetic.

[0085] In a fourth embodiment, the present invention relates to the use of the composition of the first embodiment for providing protection from UV-induced damage. Preferably, the use is essentially non-therapeutic or cosmetic.

[0086] In a fifth aspect, the present invention relates to the use of carboxymethylcysteine ​​compounds in providing protection from damage caused by visible light. Preferably, the use is essentially non-therapeutic or cosmetic.

[0087] In another embodiment, the present invention relates to the use of carboxymethylcysteine ​​compounds in a personal care composition comprising one or more oil-soluble sunscreens and one or more water-soluble sunscreens to provide protection from damage caused by visible light. Preferably, the use is essentially non-therapeutic or cosmetic.

[0088] In a sixth aspect, the present invention relates to the use of carboxymethylcysteine ​​compounds as antioxidants. Carboxymethylcysteine ​​compounds have been found to reduce ROS generation. When such carboxymethylcysteine ​​compounds are combined with one or more sunscreens, a synergistic antioxidant effect is obtained. Preferably, the use is essentially non-therapeutic or cosmetic.

[0089] The present invention will be further described with the help of the following non-limiting embodiments.

[0090] [Examples] Implementation Guidelines Culture medium and reagents Growth media and supplements for keratinocytes (HaCaT cell lines), including DMEM, were purchased from Cascade Biologics (USA) and reconstituted according to the supplier's instructions, along with supplied growth factors and antibiotics (100 U / mL penicillin and 100 μg / mL streptomycin). Trypsin EDTA and trypsin neutralizers were obtained from Cascade Biologics (USA). LCC (commercially available as HAIR APP, 98% active) was sourced from Sinerga.

[0091] Cell culture and exposure to UV and blue light Place keratinocytes (HaCaT cells) in a 48-well plate in a 3.5 × 10⁶ arrangement. 4 Cells were seeded at a cell / well density and maintained in DMEM medium reconstituted as described above for 24–48 hours. If necessary, cells were exposed to UV light using a solar simulator with a xenon arc lamp and to blue light using an LED light source. As a control (Example A), cells that were not exposed to either UV or blue light were used. Before exposure, the composition (shown in Table 1 below) was uniformly spread onto PMMA plates (2 mg / cm²). 2 ). For UV / blue light exposure, the culture medium was carefully removed and the cells were gently washed with sterile 1X phosphate-buffered saline (PBS). Exposure was performed using a PMMA plate on top of a culture plate with a minimum level of 1X PBS covering the lid and cell layer. After exposure, the PBS was removed and replaced with culture medium in all wells. To mimic LCC penetration into the skin, some cells were treated with a medium containing LCC as shown in the cases of Examples D and 1 in Tables 2 and 3 below. The plates were incubated in a 5% CO2 / 37°C incubator for 6 hours, and after incubation, cells were harvested and ROS levels were measured by the DCFDA assay.

[0092] DCFDA assay Cells with and without UVA at 100 mJ / cm² 2Exposed and then incubated at 37°C for 6 hours in a CO2 incubator. After 6 hours, the cells were washed with 1XPBS, treated with a medium containing DCFDA reagent, and incubated at 37°C for 30 minutes in a CO2 incubator. Then, the cells were washed once with 1XPBS and fresh PBS was added. Then, the plate was wrapped with aluminum foil and read at an excitation wavelength of 485 nm and an emission wavelength of 535 nm. The amount of ROS generated was calculated as a percentage of the control after background subtraction.

[0093] SPF and UVAPF Measurements The in vitro SPF and UVAPF values of the samples shown in Table 4 below were measured using the following procedure.

[0094] Film transmittance measurements were performed using a Labsphere ultraviolet transmittance analyzer. In this investigation, a 70×70 mm PMMA plate with a roughness of approximately 6 μm from Schonberg GmbH&Co was used. The transmittance percentages of various compositions were measured using the procedure outlined below. 2 mg / cm 2 of the sample was applied to the PMMA plate, distributed evenly using a syringe, and spread evenly. The drying time of the PMMA plate was 30 minutes. After the drying time, the sample plate was exposed to UV light and a transmittance scan was recorded. This scan gives the transmittance as a function of wavelength (290 - 400 nm) for a given sample. For a single plate, 6 - 9 different spots were scanned. The same was repeated for two or three plates. Thus, the reported data is the average of 12 - 18 readings. A blank plate with no sample placed on a PMMA plate spread with glycerin was used to obtain a reference transmittance scan. Using the transmittance values, the SPF value was reached using the UV-2000s application equipped with the instrument.

[0095] The percentage of transmittance (and therefore SPF) was measured in vitro at 0:00 (line 0 min) using SPF. The same plate was exposed to simulated sunlight, and the transmittance % was measured at specified time intervals from 0 min to 60 min. The average absorbance at 310 nm and 355 nm was recorded to measure % UVB and UVA photostability, respectively. UV was measured at 550 Wm -2 It was generated using a solar simulator (Atlas kW system) at a distance of approximately 20 cm using the irradiance.

[0096] [Examples] As described above, cells not exposed to UV or blue light were used as a control and designated as Example A. Furthermore, the compositions shown in Table 1, Examples B, C, D and 1 were prepared.

[0097] In short, these compositions were prepared as follows:

[0098] In a container, phenylbenzimidazole sulfonic acid (Enthrisol) was neutralized with pre-weighed sodium hydroxide to obtain a homogeneous, clear solution. The pre-neutralized Enthrisol, EDTA, and glycerin were added to water in the main container and homogenized at 75°C (aqueous phase). Hysteric acid, glyceryl stearate, glycol monostearate, PEG-100 stearate, octocrylene, butyl methoxydibenzoylmethane, octyl salicylate, and a emollient were added to separate containers and melted at 75°C to obtain a clear oil phase. DC 9701 or acrylate crosspolymer (e.g., available as Ganezpearl 820 GMP) was pre-dispersed in the molten oil phase using a spatula before addition. Meanwhile, in a separate container, the required polymers, such as xanthan gum and Ultrez 10 (carbomer, cross-linked polyacrylic acid), were dispersed in water (polymer phase). A molten oil phase containing sunscreen and sensory modifiers was added to the main container and homogenized for complete mixing. A pre-dispersed polymer was added to this mixture and mixing continued. At this stage, the polymer was neutralized with KOH (45%). After neutralization, dimethicone was added to the main container and mixing continued for another 5-8 minutes. While continuously mixing, the temperature of the main container was lowered to 45°C, and the bioactive substance was added, mixing continued until it reached room temperature. The formulation was stored overnight, and the in vitro SPF was measured the following day. [Table 1] The compositions shown in Table 1 above were exposed to blue light as previously described, and ROS generation was measured together with Example A (unexposed control) using the DCFDA assay as described above, as shown in Table 2 below. [Table 2] The data in Table 2 above shows that when carboxymethylcysteine ​​compounds, such as LCC, are used in combination with one or more sunscreens, ROS production is synergistically reduced even when cells are exposed to blue light.

[0099] Furthermore, the compositions shown in Table 1 above were exposed to UV light as previously described, and ROS generation was measured as described above. Here again, Example A was used as the unexposed control. [Table 3] The data in Table 3 above shows that when carboxymethylcysteine ​​compounds, such as LCC, are used in combination with one or more sunscreens, ROS production is synergistically reduced even when cells are exposed to UV light.

[0100] The data in Tables 2 and 3 above demonstrate that carboxymethylcysteine ​​compounds, such as LCC, function as antioxidants by reducing ROS production.

[0101] Furthermore, the compositions shown in Table 4 below were prepared as described above, and the SPF and UVAPF measurements were recorded using the aforementioned implementation guidelines. [Table 4] Table 5: The SPF and UVAPF data obtained for the compositions shown in Table 4 above were as follows: [Table 5] The data in Table 5 above shows that carboxymethylcysteine ​​compounds improve the SPF of the composition.

[0102] Furthermore, the compositions shown in Table 6 below were prepared. [Table 6] The skin whitening effects of the compositions shown in Examples H, I, and 3 were evaluated in a living skin equivalent (PLSE) (MelaKuits®, Biocell, Xi'an, China) model exposed to UV light and pigmented. After constructing the model (Day 0), 50 mJ / cm³ was applied to the model. 2The samples were irradiated with UVB once daily for 6 days. Compositions from Examples H, I, and 3 were applied topically at a dose of 5 μL on days 2, 4, and 6. On day 7, the L* value of each model was measured using a DSM II ColorMeter. The results are shown in Table 7 below. [Table 7]

Claims

1. Personal care composition, a. Carboxymethylcysteine ​​compounds selected from carboxymethylcysteine, carboxymethylcysteine ​​esters, carboxymethylcysteine ​​amides, carboxymethylcysteine ​​salts, and mixtures thereof. b. One or more oil-soluble sunscreens in an amount of 0.1 to 15 wt%, and c. A composition comprising 0.1 to 10 wt% of one or more water-soluble sunscreens.

2. The composition according to claim 1, wherein the composition comprises 0.00001 to 10 wt% of the carboxymethylcysteine ​​compound.

3. The composition according to any one of claims 1 or 2, wherein the carboxymethylcysteine ​​compound comprises carboxymethylcysteine, esters of carboxymethylcysteine, salts of carboxymethylcysteine, and mixtures thereof.

4. The composition according to any one of claims 1 to 3, wherein the carboxymethylcysteine ​​compound comprises L-lysine 1:1, which is formed by the combination of S-(carboxymethyl)-L-cysteine.

5. The one or more oil-soluble sunscreens described above, a. UV-B sunscreens selected from one or more of octyl salicylate, 3,3,5-trimethylchlorohexyl 2-hydroxybenzoate, ethylhexyl salicylate, 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate, 2-ethylhexyl-4-methoxycinnamate, and octyl methoxycinnamate, and / or b. A composition according to any one of claims 1 to 4, selected from one or more dibenzoylmethane compounds, diethylaminohydroxybenzoylhexyl benzoate, and methyl anthranilate, which is a UV-A sunscreen.

6. The composition according to claim 5, wherein the dibenzoylmethane compound is selected from one or more of t-butylmethoxydibenzoylmethane, 2-methyldibenzoylmethane, 4-methyl-dibenzoylethane, 4-isopropyldibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4-dimethyldibenzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4'-diisopropyldibenzoylmethane, 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane, 2-methyl-5-tert-butyl-4'-methoxydibenzoylmethane, 2,4-dimethyl-4'-methoxydibenzoylmethane, and 2,6-dimethyl-4-tert-butyl-4'-methoxydibenzoylmethane.

7. The one or more water-soluble sunscreens described above a. A UV-B sunscreen selected from one or more of 2-phenylbenzimidazole-5-sulfonic acid, benzophenone-4, and benzylidene camphor sulfonic acid, and / or b. A composition according to any one of claims 1 to 6, selected from one or more UV-A sunscreens selected from phenyldibenzimidazole tetrasulfonate disodium and terephthalylidene dicamphor sulfonic acid.

8. The composition according to any one of claims 1 to 7, wherein the composition further comprises one or more nonionic surfactants having an HLB value in the range of 9 to 20, selected from fatty alcohol ethoxylates, fatty acid ethoxylates, alkylphenol ethoxylates, and polyoxyethylene sorbitan alkyl esters, preferably selected from fatty alcohol ethoxylates or fatty acid ethoxylates.

9. The composition according to any one of claims 1 to 8, wherein the composition further comprises one or more humectants selected from propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, isoprene glycol, 1,2,6-hexanetriol, glycerol, ethoxylated glycerol, and propoxylated glycerol.

10. The composition contains 3 to 25 wt% C ８ ~C ２２ The composition according to any one of claims 1 to 9, further comprising a fatty acid, preferably palmitic acid and / or stearic acid.

11. The composition according to any one of claims 1 to 10, wherein the composition further comprises a polymer of a dimethicone / vinyl dimethicone crosspolymer that contains or does not contain silica.

12. A method that provides protection to the surface from damage caused by the sun, a. The process includes the step of applying the composition according to any one of claims 1 to 11 to the surface, b. A method which may include rinsing the surface.

13. Use of the composition according to any one of claims 1 to 11 to provide protection from damage caused by the sun.

14. Use of the composition according to any one of claims 1 to 11 to provide protection from UV-induced damage.

15. The use of carboxymethylcysteine ​​compounds in providing protection from damage caused by visible light.

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