Novel heterocyclic compounds for regulating P53 function

Abstract

The present invention discloses novel fused ring or macroheterocyclic compounds that have a regulatory effect on abnormalities in the P53 signaling pathway, and more specifically, discloses compounds represented by the structure of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, isotopic substitutions or isomers thereof, as P53 mutation target modifiers. [C277] TIFF2026527642000305.tif35170

Description

[Technical Field]

[0001] The present invention Priority rights to the prior application filed with the China National Intellectual Property Administration on August 9, 2023, application number 202310999503.3, titled "Novel Heterocyclic Compounds for Regulating P53 Function," Claiming priority to the prior application filed with the China National Intellectual Property Administration on June 12, 2024, application number 202410754113.4, titled "Novel Heterocyclic Compounds for Regulating P53 Function," The entire text of the aforementioned prior application is incorporated herein by reference.

[0002] The present invention belongs to the field of medicinal chemistry and specifically includes novel aromatic ring compounds capable of modulating P53 function, compositions containing such compounds, and methods for applying such compounds to the preparation of agents for treating or preventing diseases associated with abnormalities in the P53 gene / protein or signaling pathway (e.g., tumors, autoimmune diseases, etc.). [Background technology]

[0003] In recent years, the treatment of tumors has advanced significantly with the emergence of many drugs, but cancer remains a major disease that seriously threatens human health and lifespan. The mechanisms of cancer development are complex and diverse, and P53 is one of the most prominent examples. The P53 tumor suppressor gene is a gene that suppresses the transformation of cells into cancer cells in the body. The human P53 gene is located on chromosome 17, P13, is 16-20 kb in length, contains 11 exons, transcribes 2.8 kb of mRNA, and encodes the protein P53, which is a nuclear phosphorylated protein. P53 is the gene most strongly correlated with human tumors discovered to date. The P53 protein, the expression product of the P53 gene, consists of 393 amino acid residues, exists in the body as a tetramer, and has a half-life of 20-30 minutes.

[0004] Under normal conditions, the content of P53 protein in cells is very low and its half-life is short, making it difficult to detect. However, in proliferating cells, it can increase by 5 to 100 times or more. The P53 gene constantly monitors the integrity of cellular chromosome DNA. When cellular chromosome DNA is damaged, the P53 protein binds to the corresponding binding site on the gene DNA and acts as a specialized transcription factor, activating the transcription of the P21 gene, arresting the cell in the G1 phase, suppressing helicase activity, and interacting with replication factor A to participate in DNA replication and repair. If repair fails, the P53 protein initiates programmed cell death (apoptosis) to induce cell suicide and prevent the generation of cancer-prone mutant cells, thus preventing cell malignancy.

[0005] Previously considered an oncogene, it wasn't until 1989 that it was discovered that mutated P53 was the one acting as an oncogene, and subsequently, wild-type P53 was demonstrated to be a tumor suppressor gene. The wild-type P53 protein plays a crucial role in maintaining normal cell proliferation and suppressing malignant growth, earning it the title of "guardian of the genome." When a mutation occurs in the P53 gene, the spatial conformation affects transcriptional activation function and the phosphorylation process of the P53 protein. This not only causes wild-type P53 to lose its tumor growth suppressive effect, but the mutation itself also gives the gene oncogene function. The mutated P53 protein binds to the wild-type P53 protein, and the resulting oligomeric protein cannot bind to DNA, leading to uncontrolled transcription of some oncogenes and ultimately tumor development.

[0006] The P53 gene is associated with 50% of human tumors, including liver cancer, breast cancer, bladder cancer, gastric cancer, colon cancer, prostate cancer, soft tissue sarcoma, ovarian cancer, brain tumors, lymphocyte tumors, esophageal cancer, lung cancer, and osteosarcoma. P53 mutations in human tumors are mainly located within highly conserved regions and vary depending on the type of tumor. For example, colon cancer and breast cancer have similar epidemiologies, but their P53 mutation spectra do not match, making the development of inhibitors against P53 mutations highly desirable.

[0007] Despite the existence of widespread unmet needs, there are currently only a few patent reports, such as WO2021231474, WO2021262483, and WO2021061643, for compounds effective in suppressing P53 protein mutations. [Overview of the project] [Effects of the Invention]

[0008] The inventors have surprisingly discovered that some of the novel heterocyclic compounds containing a phosphorus oxygen group or a sulfur oxygen group having the structure of formula (I) of the present invention not only have a remarkable ability to bind to P53 mutant proteins, but can also restore the DNA binding function of the mutants after binding. Compared to similar reference compounds of known structures in the patent, these compounds have properties such as higher tumor cell proliferation inhibitory activity, better pharmacokinetic properties (including better permeability, lower clearance rate, longer T1 / 2 and higher exposure), and bioavailability, and are expected to have superior human PK properties. Some representative compounds also have excellent brain permeability, making them more suitable for development as drug candidates used for the prevention or treatment of diseases associated with P53 mutant targets and their signaling pathways. [Means for solving the problem]

[0009] The object of the present invention is to provide a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, enantiomer, and isotopic substitution thereof. [ka] (In the formula, Ring B may represent a cyclic structure of any 3 to 20 members, and may be a monocyclic, dicyclic, or tricyclic structure. The cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining aromatic rings, heteroaromatic rings, aliphatic rings, heterocyclic rings, and bridging rings. Z3 is absent, single bond, -C(R d1 )(R d2 )-, -C(=Rd1 )-, -(R d1 )P(=O)-, =C(R d1 )-, NH, -C(R d1 )(R d2 )C(R d1 )(R d2 )-, -C(R d1 )=C(R d1 )-, -C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [Chemical] , -OC(R d1 )(R d2 )-, -C(R d1 )(R d2 )O-, -NHC(R d1 )(R d2 )-, -C(R d1 )(R d2 )NH-, -C(=O)N(R d3 ​​​​​​​​​​​​​​​​​​​​​​Each R1 may be the same or different, and independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, amide group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group, or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C1-10 an alkylsulfonyl group, C 1-10 an alkylsulfinyl group, C 3-10 a cycloalkylamino group, C 3-10 a heterocycloalkylamino group, C 3-10 a cycloalkoxy group, C 3-10 a heterocycloalkoxy group, C 3-10 a cycloalkylacyl group, C 3-10 a cycloalkoxyacetyl group, C 3-10 a cycloalkylsulfonyl group and C 3-10 a cycloalkylsulfinyl group, -Y-Q or an M group, or optionally two R2s together with the atoms to which they are attached may form a 5- to 6-membered aryl or heteroaryl group, a 3- to 8-membered saturated or partially saturated cycloalkyl group, or a 3- to 8-membered saturated or partially saturated heterocyclyl group, and the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, heterocyclyl group are optionally substituted with one or more groups selected from hydrogen, deuterium, an alkyl group, a halogen, a pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, and the hydrogen on R2 is hydrogen, deuterium, a halogen, a pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 an alkyl group, C 1-6 an alkoxy group, -NH2, -NHC 1-6 an alkyl, -N(C 1-6 an alkyl)2, an oxy group, a haloalkyl group, a deuterated alkyl group, and a saturated or partially saturated C 3-6 a cycloalkyl group or a heterocycloalkyl group, optionally substituted with one or more selected therefrom, M is

Chemical formula

[0010] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IA). [ka] (In the formula, Y, Y1, Y2, Y3, Y4, and Y5 are each independent of nonexistence, single bond, and -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-, N, -C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2)NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A saturated or partially saturated heteroaryl group is selected, and the hydrogens on Y, Y1, Y2, Y3, Y4, Y5 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Ring B may represent a cyclic structure of any 3 to 20 members, and may be a monocyclic, dicyclic, or tricyclic structure. The cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining aromatic rings, heteroaromatic rings, aliphatic rings, heterocyclic rings, and bridging rings. Z3 is absent, single bond, -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z3 is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, X1 is selected independently of N or CR. Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent or M group substituted with an alkyl group is selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z does not exist, C(R d1 )(R d2 ), O, NR d1 , -C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(Rd2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogens on Z1 and Z2 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R a R1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , Rd2 , R d3 , R d4 , R d5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily chosen from 0, 1, 2, 3, 4, and 5.

[0011] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IB). [ka] (In the formula, Y, Y1, Y2, Y3, Y4, Y5 are each independent of -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A saturated or partially saturated heteroaryl group is selected, and the hydrogens on Y, Y1, Y2, Y3, Y4, Y5 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Z3 is absent, single bond, -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z3 is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, X is O, S, N(R d4 ), -C(R d1 )(R d2 )-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 A saturated or partially saturated aryl group, or -C(R d1 )=C(R d1 )- Selected independently from, X1 is selected independently of N or CR. Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, sulfamoyl group, sulfamoylamide group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent or M group substituted with an alkyl group is selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10 The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z does not exist, C(R d1 )(R d2 ), O, NR d1 , -C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogens on Z1 and Z2 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R a R1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0012] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IC). [ka] (In the formula, Y, Y1, Y2, Y3, Y4, Y5 are each independent of -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2)-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A saturated or partially saturated heteroaryl group is selected, and the hydrogens on Y, Y1, Y2, Y3, Y4, Y5 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Z3 is absent, single bond, -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(Rd1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z3 is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, X is selected independently of N or -CR-, X1 is selected independently of N or CR. Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, sulfamoyl group, sulfamoylamide group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent or M group substituted with an alkyl group is selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R2s together with the atoms to which they are attached form a 5- to 6-membered aryl or heteroaryl group, a 3- to 8-membered saturated or partially saturated cycloalkyl group, or a 3- to 8-membered saturated or partially saturated heterocyclyl group, and the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, heterocyclyl group are optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, and the hydrogen on R2 is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 alkyl group, C 1-6 alkoxy group, -NH2, -NHC 1-6 alkyl, -N(C 1-6 alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 selected from one or more of a cycloalkyl group or heterocycloalkyl group and optionally substituted, M is

Chemical formula

Chemical formula

[0013] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (ID). [ka] (In the formula, Y1, Y2, Y3, Y4, and Y5 are each independently -C(R d1 )(Rd2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A saturated or partially saturated heteroaryl group is selected, and the hydrogens on Y1, Y2, Y3, Y4, and Y5 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, and C. 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxys, X is selected independently of N or -CR-, X1 is selected independently of N or CR. Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, sulfamoyl group, sulfamoylamide group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent or M group substituted with an alkyl group is selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10 The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z does not exist, C(R d1 )(R d2 ), O, NR d1 , -C(R d1 )(R d2 )C(R d1 )(Rd2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogens on Z1 and Z2 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R aR1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0014] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound or its isomer has the structure of formula (IE). [ka] (In the formula, Y1, Y2, Y3, Y4, and Y5 are each independently -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A saturated or partially saturated heteroaryl group is selected, and the hydrogens on Y1, Y2, Y3, Y4, and Y5 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, and C. 1-3 Alkyl, C 1-3 Arbitrarily selected from alkoxys, X is selected independently of N or -CR-, X1 is selected independently of N or CR. Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, amide group, sulfamoylamino group, methanesulfonamide group, or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected from these, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10 The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z does not exist, C(R d1 )(R d2 ), O, NR d1 , -C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogens on Z1 and Z2 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R a R1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0015] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IF). [ka] (In the formula, Y, Y1, Y2, Y3, Y4, and Y5 are each independently -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(Rd4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A saturated or partially saturated heteroaryl group is selected, and the hydrogens on Y1, Y2, Y3, Y4, and Y5 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, and C. 1-3 Alkyl, C 1-3 Arbitrarily selected from alkoxys, Ring C may optionally represent a 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may optionally be hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, X is selected independently of N or -CR-, X1 is selected independently of N or CR. Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10 The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z does not exist, C(R d1 )(R d2 ), O, NR d1 , -C(R d1 )(R d2 )C(R d1 )(Rd2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogens on Z1 and Z2 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R aR1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0016] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IG). [ka] (In the formula, Y, Y1, Y2, Y3, Y4, and Y5 are each independently -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A saturated or partially saturated heteroaryl group is selected, and the hydrogens on Y1, Y2, Y3, Y4, and Y5 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, and C. 1-3 Alkyl, C 1-3 Arbitrarily selected from alkoxys, Ring C may optionally represent a 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may optionally be hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, X1 is selected independently of N or CR. Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z does not exist, C(R d1 )(R d2 ), O, NR d1 , -C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(Rd2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogens on Z1 and Z2 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R a R1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , Rd5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0017] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IH). [ka] (In the formula, Y is -C(R d1 )(R d2 )-, -C(=Rd1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Y is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, X is selected independently of N or -CR-, X1 is selected independently of N or CR. Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, amide group, aminoacyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methylsulfonamide group, or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10 The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z does not exist, C(R d1 )(R d2 ), O, NR d1 , -C(R d1 )(R d2 )C(R d1 )(Rd2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogens on Z1 and Z2 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R aR1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, and at least one R d1 and R d2 These atoms are linked together, forming a 3-20 membered ring structure with the atoms they are bonded to. The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0018] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (II). [ka] (In the formula, Y is -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6)-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Y is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, X1 is selected independently of N or CR. Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z does not exist, C(R d1 )(R d2 ), O, NR d1 , -C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(Rd2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogens on Z1 and Z2 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl, C 1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R a R1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , Rd5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, and at least one R d1 and R d2 These atoms are linked together, forming a 3-20 membered ring structure with the atoms they are bonded to. The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0019] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IJ). [ka] (In the formula, [ka] represents either a single bond or a double bond, Z3 is absent, single bond, -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z3 is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, X1 and X2 are selected independently of N or CR. Y is -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- are independently selected, Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, acyl group, carboxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C3-10 heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10 The two R2 groups, selected from cycloalkylsulfinyl, -YQ, or M groups, may optionally form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocyclyl group may optionally be substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, pentafluorosulfanyl, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 may be hydrogen, deuterium, halogen, pentafluorosulfanyl, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, heterocycloalkyl groups, -YQ groups, or M groups, M is [ka] Selected arbitrarily and independently from, Z does not exist, C(R d1 )(R d2 ), O, NR d1 , -C(R d1 )(R d2 )C(Rd1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogens on Z1 and Z2 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Y is arbitrarily and independently selected from O, S, or NR. Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R aR1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4.

[0020] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IK). [ka] (In the formula, [ka] represents either a single bond or a double bond, Z3 is absent, single bond, -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6)-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2-, or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z3 is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, X1 and X2 are selected independently of N or CR. Y is -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(Rd6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- are independently selected, Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, acyl group, carboxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C3-10 heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10 The two R2 groups, selected from cycloalkylsulfinyl, -YQ, or M groups, may optionally form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, or heterocyclyl group may optionally be substituted with one or more groups selected from hydrogen, deuterium, alkyl, halogen, pentafluorosulfanyl, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 may be hydrogen, deuterium, halogen, pentafluorosulfanyl, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, heterocycloalkyl groups, -YQ groups, or M groups, M is [ka] Selected arbitrarily and independently from, Z does not exist, C(R d1 )(R d2 ), O, NR d1, -C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogens on Z1 and Z2 are further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, Y is arbitrarily and independently selected from O, S, or NR. Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R aR1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4.

[0021] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IM). [ka] (In the formula, Y3 and Y4 are -C(R d1 )(R d2 )-, O, -C(R d1 )(R d2 )C(R d1 )(R d2 )- or -C(=O)- are selected independently, Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z is nonexistent, C(R d1 )(R d2 ), NR d1 , -C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(Rd2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z is further optionally substituted, preferably, with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Selectively chosen from alkoxy groups, Y is -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(Rd2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 Selected independently from saturated or partially saturated heteroaryl groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R a R1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, and 3. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0022] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IN). [ka] (In the formula, Y3 and Y4 are -C(R d1 )(R d2 )-, O, -C(R d1 )(R d2 )C(R d1 )(R d2 )- or -C(=O)- are selected independently, Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkoxy group, C1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10 The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z is nonexistent, C(R d1 )(R d2 ), NR d1 , -C(R d1 )(R d2 )C(R d1 )(Rd2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z is further optionally substituted, preferably, with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Selectively chosen from alkoxy groups, Y is -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(R d1 )(R d2 )C(R d1 )(Rd2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 Selected independently from saturated or partially saturated heteroaryl groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R a R1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , Rd5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, and 3. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0023] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IO). [ka] (In the formula, Y3 and Y4 are -C(R d1 )(R d2)-, O, -C(R d1 )(R d2 )C(R d1 )(R d2 )- or -C(=O)- are selected independently, Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C1-10 Alkylacyl group, C 1-10 Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10 The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z is nonexistent, C(R d1 )(R d2 ), NR d1 , -C(Rd1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z is further optionally substituted, preferably, with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Selectively chosen from alkoxy groups, Y is -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(Rd1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 Selected independently from saturated or partially saturated heteroaryl groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R a R1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , Rd5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, and 3. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0024] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound, or an isomer thereof has the structure of formula (IP). [ka] (In the formula, Y3 and Y4 are -C(R d1 )(R d2)-, O, -C(R d1 )(R d2 )C(R d1 )(R d2 )- or -C(=O)- are selected independently, Each R1 may be the same or different, and may be independently selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH2, -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected, and the hydrogen on R1 is optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, OCH3, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R1s together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a group selected from cycloalkyl groups, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 The molecule is optionally substituted with one or more groups selected from cycloalkyl groups, and the hydrogen on R1 is optionally substituted with hydrogen, preferably deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R2 may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group, C 1-10 Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C 1-10 Alkyl)amino, C 1-10 Alkoxy group, C1-10 Alkylacyl group, C 1-10 Alkoxy group, C 1-10 Alkyl sulfonyl group, C 1-10 Alkyl sulfinyl group, C 3-10 Cycloalkylamino group, C 3-10 Heterocycloalkylamino group, C 3-10 Cycloalkoxy group, C 3-10 Heterocycloalkoxy group, C 3-10 Cycloalkylacyl group, C 3-10 Cycloalkoxyacetyl group, C 3-10 Cycloalkylsulfonyl group and C 3-10 The R2 groups are selected from cycloalkylsulfinyl groups, -YQ or M groups, or optionally, two R2 groups together with the atom to which they are bonded may form a 5-6 membered aryl or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group, wherein the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, or heterocyclyl group is optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF3, OH, OCH3, or OCH2CH3, and the hydrogen on R2 is either hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is [ka] Selected arbitrarily and independently from, Z is nonexistent, C(R d1 )(R d2 ), NR d1 , -C(Rd1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-,-N(R d7 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z is further optionally substituted, preferably, with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl alkyl group, C 1-3 Selectively chosen from alkoxy groups, Y is -C(R d1 )(R d2 )-, -C(=R d1 )-,-(R d1 )P(=O)-,=C(R d1 )-,NH,-C(Rd1 )(R d2 )C(R d1 )(R d2 )-,-C(R d1 )=C(R d1 )-,-C(R d1 )(R d2 )C(R d1 )=C(R d1 )-, [ka] , -OC(R d1 )(R d2 )-,-C(R d1 )(R d2 )O-,-NHC(R d1 )(R d2 )-,-C(R d1 )(R d2 )NH-, -C(=O)N(R d3 )-,-N(R d4 )-, -C(=NR d5 )-,-S(=O)2N(R d6 )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O)2- or C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 4-10 Saturated or partially saturated aryl group, C 4-10 Selected independently from saturated or partially saturated heteroaryl groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and independently selected from hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH2, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 2-10 Heteroalkyl groups, C 3-10 Saturated or partially saturated cycloalkyl groups, C 3-10 Saturated or partially saturated heterocycloalkyl groups, C 3-10 Cycloalkyl groups or C 3-10 C substituted with heterocycloalkyl groups 1-10 Alkyl alkyl group, C 3-10 C substituted with a cycloalkyl group 2-10 Heteroalkyl groups, C 3-10 Heterocyclyl group, C 1-10 A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C 1-3 Alkyl, C 1-3 Arbitrarily selected from alkoxy groups, R a and R b These are optionally and independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkenyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R a and R b Or R a and R2 or R a R1 and R1 may be linked together to form a 3-30 membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R a The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C 3-6 Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R d1 , R d2 , R d3 , R d4 , R d5 , R d6 , R d7 Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH2, C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Selected from heterocyclyl groups, the C 1-10 Alkyl alkyl group, C 2-10 Alkynyl group or C 1-10 Alkoxy group, C 1-10 Alkylacyl group, C 1-10 Alkyl sulfonyl group, C 2-10 Heteroalkyl groups, C 3-10 Cycloalkyl groups, C 3-10 Heterocycloalkyl groups, C 3-10 C substituted with cyclic hydrocarbon groups 1-10 Alkyl or C 3-10 Cycloalkyl groups, C 3-10 C substituted with heterocycloalkyl groups 3-10 Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C 3-10 Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R d1 , R d2 , R d3 , R d4 , Rd5 , R d6 , R d7 These atoms, together with and / or R1 or R2 and the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen atoms on the heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocycloalkyl group may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF3, or C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, =O, and saturated or partially saturated C 3-6 Optionally substituted with a cycloalkyl group, and C 1-6 Alkyl and C 1-6 Alkoxy groups include hydrogen, deuterium, halogens, pentafluorosulfanyl groups, oxo, CN, CF3, OH, OCH3, OCH2CH3, saturated or partially saturated C 3-6 Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogens are arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, and 3. n is an integer arbitrarily chosen from 0, 1, 2, 3, and 4.

[0025] In one embodiment of the present invention, the compound or a pharmaceutically acceptable salt thereof, an isotope-substituted compound thereof, or an isomer thereof has the structure of formula (III). [ka] (In the formula, X is selected from N or CR, and R is H or C 1-6 Alkyl, halo C1-6 Selected from alkyl groups, E is O, S, NR e Selected from, R e H, C 1-6 Alkyl alkyl group, C 3-6 Cycloalkyl groups, Halo C 1-6 Selected from alkyl groups, Each R1 is either the same or different, and is independent of H and C. 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, S(O)2C 1-6 Alkyl, P(O)(C 1-6 Selected from alkyl)2, Each R2 is either the same or different, and independently of each other, H, P(O)(C 1-6 Selected from alkyl)2,-NH-Q, where Q is unsubstituted or optionally one, two or more R q Selected from 5-6 member heterocyclyl groups substituted with each R q These are identical or different, and independently of each other, H, halogen, and C. 1-6 Alkyl, halo C 1-6 Selected from alkyl groups, R d1 , R d2 H, C are identical or different, and independent of each other. 1-6 Alkyl alkyl group, C 1-6 Selected from alkoxy groups, R y1 , R y2 H, C are identical or different, and independent of each other. 1-6 Alkyl alkyl group, C 1-6 Selected from alkoxy groups, or R y1 , R y2 These, together with the atoms to which they are linked, form a 5-12 membered heterocyclyl group or a 5-10 membered heteroaryl group. m is selected from 0, 1, 2, or 3. n is selected from 0, 1, 2, 3, or 4.

[0026] According to embodiments of the present invention, R is H, C 1-3 Alkyl, halo C 1-3Selected from alkyl groups.

[0027] According to embodiments of the present invention, R is selected from H and CH2CF3.

[0028] According to embodiments of the present invention, R e H, C 3-6 Cycloalkyl groups, Halo C 1-3 Selected from alkyl groups,

[0029] According to embodiments of the present invention, R e The group is selected from cyclopropyl group, CH2CF3.

[0030] According to embodiments of the present invention, [ka] Selected from.

[0031] According to embodiments of the present invention, each R1 is the same or different, and independently of each other, H, S(O)2C 1-3 Alkyl, P(O)(C 1-3 Selected from alkyl)2.

[0032] According to embodiments of the present invention, each R1 is selected from H, S(O)2CH3, and P(O)(CH3)2, either identical or different, and independently of each other.

[0033] According to embodiments of the present invention, each R2 is the same or different, and independently of each other, H, P(O)(C 1-3 Selected from alkyl)2, -NH-Q, for example, H, P(O)(C 1-3 Alkyl) 2, [ka] )

[0034] According to embodiments of the present invention, Q is either unsubstituted or optionally one, two or more R qA six-membered heterocyclyl group substituted with a certain group is selected, for example, a piperidinyl group.

[0035] According to embodiments of the present invention, each R q These are identical or different, and independently of each other, H, halogen, and C. 1-6 Alkyl groups are selected from, for example, H, F, and methyl groups.

[0036] According to embodiments of the present invention, each R2 is the same or different, and independently of each other, H, P(O)(CH3)2, [ka] ) will be selected from.

[0037] According to embodiments of the present invention, R y1 , R y2 H, C are identical or different, and independent of each other. 1-3 An alkoxy group, such as H or a methoxy group, is selected.

[0038] According to embodiments of the present invention, R y1 , R y2 These, along with the atoms to which they are linked, are 5-7 membered heterocyclyl groups, 12 membered heterocyclyl groups, or 5-6 membered heteroaryl groups, such as furan rings and dihydrofuran rings. [ka] It forms.

[0039] According to embodiments of the present invention, [ka] , selected from,

[0040] According to embodiments of the present invention, [ka] Selected from.

[0041] In some embodiments of the present invention, the above compound or its pharmaceutically acceptable salt, or its corresponding isomer or isotope substitution, is a novel compound selected from the structures disclosed in the examples herein.

[0042] The present invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound represented by formula (I), at least one of its pharmaceutically acceptable salts, solvates, enantiomers, and isotopic substitutions.

[0043] According to embodiments of the present invention, the pharmaceutical composition is formulated to be administered via a route selected from oral, injectable, rectal, nasal, pulmonary, topical, oral and sublingual, vaginal, parenteral, subcutaneous, intramuscular, intravenous, intradermal, intrathecal and epidural.

[0044] According to embodiments of the present invention, the pharmaceutical composition is preferably administered orally.

[0045] The oral dosage form is not particularly limited, and any oral dosage form known in the art can be used, preferably including known oral dosage forms in the art such as tablets, capsules, suspensions, or oral solutions.

[0046] The duration of administration of the pharmaceutical composition according to the present invention can be determined according to the severity of the disease, preferably at least one month, and may be, for example, one, two, three, four, five, or six months, and may be administered for a lifetime depending on the needs of the disease.

[0047] According to embodiments of the present invention, the pharmaceutical composition may further contain a pharmaceutically acceptable excipient, the excipient being selected from at least one of the following: fillers, disintegrants, binders, lubricants, surfactants, flavoring agents, wetting agents, pH adjusters, solubilizers or dissolving aids, and osmotic pressure adjusters. Those skilled in the art can easily determine how to select the corresponding excipient and its corresponding dosage depending on the requirements of the specific dosage form.

[0048] According to embodiments of the present invention, the pharmaceutical composition may further comprise one or more additional therapeutic agents.

[0049] Another object of the present invention is to provide the use of the above compounds in the preparation of agents for preventing and / or treating diseases associated with abnormalities in the P53 signaling pathway. Diseases associated with the P53 signaling pathway include, but are not limited to, various tumors such as lung cancer, intestinal cancer, pancreatic cancer, liver cancer, and breast cancer, and autoimmune diseases such as inflammatory bowel disease and arthritis, or proliferative disorders such as psoriasis.

[0050] The present invention also provides for the use of the compound represented by formula (I), its pharmaceutically acceptable salts, solvates, enantiomers and isotopic substitutions, and the pharmaceutical compositions thereof in the prevention and / or treatment of diseases related to the P53 signaling pathway. The diseases related to the P53 signaling pathway have the definitions described above.

[0051] The present invention also provides a method for preventing and / or treating a disease related to the P53 signaling pathway, comprising administering to a patient a prophylactic or therapeutically effective dose of at least one of the compounds represented by formula (I), its pharmaceutically acceptable salts, solvates, enantiomers, and isotopic substitutions, or administering to a patient a prophylactic or therapeutically effective dose of the pharmaceutical composition. The disease related to the P53 signaling pathway has the definition described above.

[0052] In some embodiments, the patient is a mammal, preferably a human.

[0053] Definition and explanation: C 1-10 C1, C2, C3, C4, C5, C6, C7, C8, C9 and C 10 Selected from, C 2-10 C2, C3, C4, C5, C6, C7, C8, C9 and C 10 Selected from, C 3-10This includes C3, C4, C5, C6, C7, C8, C9 and C 10 Selected from, As used herein, the term “alkyl group” should be understood to mean a linear or branched saturated monovalent hydrocarbon group having 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 carbon atoms. 1-10 It is also written as "alkyl group". For example, "C 1-8 "Alkyl group" refers to a linear or branched alkyl group having 1, 2, 3, 4, 5, 6, 7, or 8 carbon atoms. 1-6 "Alkyl group" refers to linear and branched alkyl groups having 1, 2, 3, 4, 5, or 6 carbon atoms. The alkyl groups are, for example, methyl, ethyl, propyl, butyl, pentyl, hexyl, isopropyl, isobutyl, sec-butyl, tert-butyl, isopentyl, 2-methylbutyl, 1-methylbutyl, 1-ethylpropyl, 1,2-dimethylpropyl, neopentyl, 1,1-dimethylpropyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 2-ethylbutyl, 1-ethylbutyl, 3,3-dimethylbutyl, 2,2-dimethylbutyl, 1,1-dimethylbutyl, 2,3-dimethylbutyl, 1,3-dimethylbutyl, or 1,2-dimethylbutyl, or their isomers. The term "alkylene group" as used herein refers to the group of the formula (CH2) n - Refers to a linear or branched divalent hydrocarbon group. Non-limiting examples include ethylene and propylene.

[0054] As used herein, the term "one or more" means one or more, for example, one, two, three, four, five or more.

[0055] The terms “aliphatic ring,” “carbocyclic ring (group),” or “cycloalkyl group” refer to saturated or partially unsaturated monocyclic or polycyclic cyclic hydrocarbon groups, where a carbocyclic ring may contain 3 to 20 carbon atoms, preferably 3 to 12 carbon atoms (e.g., 3, 4, 5, 6, 7, 8, 9, 10, 11, 12), more preferably 3 to 6 carbon atoms. A carbocyclic ring may be monocyclic or polycyclic, may be a saturated cycloalkyl group, or may optionally contain one, two or more double and / or triple bonds on the ring, thereby forming a so-called cycloalkenyl group or cycloalkynyl group. If a carbocyclic ring has multiple rings, these rings can form spirocyclic, fused, and bridging ring structures. For example, non-limiting examples of monocyclic carbocycles include cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cyclohexadienyl, cycloheptyl, cycloheptatrienyl, cyclooctyl, and cyclooctatetraenyl groups, while non-limiting examples of polycyclic carbocycles include decahydronaphthyl or isobornyl groups.

[0056] The terms “aryl group” or “aromatic ring” should be understood to mean a monovalent aromatic or partially aromatic monocyclic, dicyclic (e.g., fused ring, bridging ring, spirocyclic) or tricyclic hydrocarbon ring having preferably 6 to 20 carbon atoms, which may be a monoaromatic ring or a polyaromatic ring formed by condensation together, preferably “C 6-14 It is an "aryl group". 6-14 The term "aryl group" preferably refers to a monovalent aromatic or partially aromatic monocyclic, dicyclic or tricyclic hydrocarbon ring having 6, 7, 8, 9, 10, 11, 12, 13 or 14 carbon atoms ("C 6-14 "aryl group"), especially a ring having 6 carbon atoms ("C6 aryl group"), for example a phenyl group or a biphenyl group, or a ring having 9 carbon atoms ("C9 aryl group"), for example an indanyl group or an indenyl group, or a ring having 10 carbon atoms ("C 10"aryl group"), for example, a tetrahydronaphthyl group, a dihydronaphthyl group or a naphthyl group, or a ring having 13 carbon atoms ("C 13 "aryl group"), for example, a fluorenyl group, or a ring having 14 carbon atoms ("C" 14 The term "aryl group" should be understood to mean, for example, an anthracenyl group. 6-20 If an aryl group is substituted, it may be a monosubstituted or polysubstituted group. Furthermore, there are no restrictions on the site of substitution; for example, it may be an ortho, para, or meta substitution.

[0057] The term "spiro ring" refers to a ring system in which two rings share one ring-forming atom, and may include aliphatic rings, heterorings, aromatic rings, or heteroaromatic rings as described above.

[0058] The term "condensed ring" refers to a ring system in which two rings share two ring-forming atoms, and may include aliphatic rings, heterocyclic rings, aromatic rings, or heteroaromatic rings as described above.

[0059] The term "bridged ring" refers to a ring system in which two rings share three or more ring-forming atoms, and may include aliphatic rings, heterocyclic rings, aromatic rings, or heteroaromatic rings as described above.

[0060] The term “heterocyclic group” refers to a saturated or partially unsaturated monocyclic or polycyclic cyclic hydrocarbon substituent containing 3 to 20 ring atoms, where one or more ring atoms are heteroatoms or groups of atoms selected from N, O, NH, S, S(O) or S(O)2, but do not contain the –OO-, –OS- or –SS- ring portion, and the remaining ring atoms are carbon. Preferably, it contains 3 to 12 ring atoms, with 1 to 4 being heteroatoms (e.g., 1, 2, 3, and 4), and more preferably 3 to 6 ring atoms (e.g., 3, 4, 5, and 6). The heterocyclyl group can be linked to the rest of the molecule via any of the carbon atoms, a nitrogen atom (if present), or an oxygen or sulfur atom (especially if forming an onium salt). The heterocyclyl group may contain fused or bridged rings and / or spiro rings. Non-limiting examples of monocyclic heterocyclyl groups include azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothienyl, dihydroimidazolyl, dihydrofuranyl, dihydropyrazolyl, dihydropyrrolyl, dioxolanyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dithianyl, trithianyl, homopiperazinyl, and diazepanyl groups, with piperidinyl and pyrrolidinyl groups being preferred. Polycyclic heterocyclyl groups include spiro-ring, fused-ring, and cross-linking heterocyclyl groups, and may also be benzo-fused heterocyclyl groups, such as dihydroisoquinolinyl. The heterocyclyl group may be bicyclic, and non-limiting examples include hexahydrocyclopenta[c]pyrrole-2(1H)-yl and hexahydropyrrolo[1,2-a]pyrazine-2(1H)-yl. The heterocyclyl group may be partially unsaturated, that is, it may contain one or more double bonds, and non-limiting examples include dihydrofuranyl group, dihydropyranyl group, 2,5-dihydro-1H-pyrrolyl, 4H-[1,3,4]thiadiazine, 4,5-dihydrooxazolyl, or 4H-[1,4]thiadinyl.

[0061] The heterocyclyl group may be optionally substituted or unsubstituted. If substituted, the substituent is preferably one or more groups independently selected from alkyl groups, alkenyl groups, alkynyl groups, alkoxy groups, alkylthio groups, alkylamino groups, halogens, pentafluorosulfanyl groups, mercapto groups, hydroxyl groups, nitro groups, cyano groups, cycloalkyl groups, heterocycloalkyl groups, aryl groups, heteroaryl groups, cycloalkoxy groups, heterocycloalkoxy groups, cycloalkylthio groups, heterocycloalkylthio groups, oxo groups, carboxyl groups, or carboxylic acid ester groups.

[0062] In this specification, the term “heteroaryl group / heteroaromatic ring” refers to a heteroaromatic system comprising 1 to 4 heteroatoms and 5 to 20 ring atoms, the heteroatoms being selected from oxygen, sulfur, nitrogen, and phosphorus. Heteroaryl groups are preferably 5 to 10 membered (e.g., 5, 6, 7, 8, 9, or 10 membered), and more preferably 5 or 6 membered. Non-limiting examples of heteroaryl groups include thienyl, furanyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl, thia-4H-pyrazolyl, and their benzo derivatives, such as benzofuranyl, benzothienyl, benzooxazolyl, benzoisoxazolyl, benzimidazolyl, benzotriazolyl, indazolyl, indolyl, isoindolyl, or pyridinyl This includes, but is not limited to, groups such as the yl group, pyridadinyl group, pyrimidinyl group, pyrazinyl group, triazinyl group, and their benzo derivatives, such as the quinolinyl group, quinazolinyl group, isoquinolinyl group, or the azosinyl group, indolidinyl group, prinyl group, and their benzo derivatives, or the sinnolinyl group, phthalazinyl group, quinazolinyl group, quinoxalinyl group, naphthylidinyl group, pteridinyl group, carbazolyl group, acridinyl group, phenadinyl group, phenothiazinyl group and / or phenoxadinyl group.

[0063] The heteroaryl group / heteroaromatic ring may be optionally substituted or unsubstituted. If substituted, the substituent is preferably one, two or more groups independently selected from the group consisting of alkyl groups, alkenyl groups, alkynyl groups, alkoxy groups, alkylthio groups, alkylamino groups, halogens, pentafluorosulfanyl groups, mercapto groups, hydroxyl groups, nitro groups, cyano groups, cycloalkyl groups, heterocycloalkyl groups, aryl groups, heteroaryl groups, cycloalkoxy groups, heterocycloalkoxy groups, cycloalkylthio groups, heterocycloalkylthio groups, carboxyl groups, or carboxylic acid ester groups.

[0064] Unless otherwise specified, heterocyclyl groups, heteroaryl groups, or heteroaromatic rings include all possible isomeric forms of their regioisomers, e.g., their positional isomers. Thus, some exemplary, non-limiting examples may include forms of their substituted or bonded to other groups at one, two or more positions (if any) such as the 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9-, 10-, 11-, 12-positions, etc., including pyridine-2-yl, pyridine-2-ylene, pyridine-3-yl, pyridine-3-yl, pyridine-4-yl and pyridine-4-ylene, thienyl groups or thienylene groups (including thiophene-2-yl, thiophene-2-ylene, thiophene-3-yl and thiophene-3-ylene), pyrazole-1-yl, pyrazole-3-yl, pyrazole-4-yl and pyrazole-5-yl.

[0065] The term “pharmaceutically acceptable” as used herein means a compound, material, composition and / or dosage form that is suitable for use in contact with human and animal tissues, within the bounds of reliable medical judgment, without excessive toxicity, irritation, allergic reactions or other problems or complications, and in proportion to a reasonable benefit / risk ratio.

[0066] The term "pharmaceutically acceptable salt" refers to a salt of the compound of the present invention, which is prepared from a compound found in the present invention having a specific substituent and a relatively non-toxic acid or base. If the compound of the present invention contains a relatively acidic functional group, a base addition salt can be obtained by contacting a sufficient amount of base with the neutral form of these compounds in a pure solution or a suitable inert solvent. Pharmaceutically acceptable base addition salts include sodium, potassium, calcium, ammonium, organic amine, or magnesium salts or similar salts. If the compound of the present invention contains a relatively basic functional group, an acid addition salt can be obtained by contacting a sufficient amount of acid with the neutral form of these compounds in a pure solution or a suitable inert solvent. Examples of pharmaceutically acceptable acid addition salts include inorganic and organic acid salts, further including salts of amino acids (e.g., arginine) and salts of organic acids such as glucuronic acid, where the inorganic acids include, for example, hydrochloric acid, hydrobromic acid, nitric acid, carbonic acid, bicarbonate, phosphoric acid, monohydrogen phosphate, dihydrogen phosphate, sulfuric acid, bisulfate, hydroiodic acid, and phosphorous acid, and the organic acids include, for example, acetic acid, propionic acid, isobutyric acid, maleic acid, malonic acid, benzoic acid, succinic acid, suberic acid, fumaric acid, lactic acid, mandelic acid, phthalic acid, benzenesulfonic acid, p-toluenesulfonic acid, citric acid, tartaric acid, and methanesulfonic acid (see Berge et al., “Pharmaceutical Salts”, Journal of Pharmaceutical Science 66: 1-19 (1977)). Certain compounds of the present invention contain basic and acidic functional groups, thereby allowing them to be converted into any base or acid addition salt.

[0067] Preferably, the neutral form of the compound is regenerated by contacting the salt with a base or acid using conventional methods, and then isolating the parent compound. The parent form of the compound differs from its various salt forms in that it has certain physical properties, such as solubility in polar solvents.

[0068] As used herein, “pharmaceutically acceptable salts” belong to derivatives of the compounds of the present invention that modify the parent compound by forming a salt with an acid or a salt with a base. Examples of pharmaceutically acceptable salts include, but are not limited to, inorganic or organic acid salts of bases such as amines, and alkali metal or organic salts of acid roots such as carboxylic acids. pharmaceutically acceptable salts include conventional non-toxic salts such as sodium salts, potassium salts, amine salts, and quaternary ammonium salts of the parent compound. Conventional non-toxic salts include, but are not limited to, inorganic acids and organic acids, inorganic bases and salts derived from organic bases, and the inorganic or organic acids include 2-acetoxybenzoic acid, 2-hydroxyethanesulfonic acid, acetic acid, ascorbic acid, benzenesulfonic acid, benzoic acid, bicarbonate, carbonic acid, citric acid, EDTA, ethanedisulfonic acid, ethanesulfonic acid, fumaric acid, glucoheptonic acid, gluconic acid, glutamic acid, glycolic acid, hydrobromic acid, hydrochloric acid, hydroiodide salts, hydroxyl groups, hydroxynaphthalene, isethionic acid, lactic acid, and The inorganic and organic bases are selected from the following: ctose, dodecyl sulfonic acid, maleic acid, malic acid, mandelic acid, methanesulfonic acid, nitric acid, oxalic acid, pamoic acid, pantothenic acid, phenylacetic acid, phosphoric acid, polygalacturonic acid, propionic acid, salicylic acid, stearic acid, acetic acid, succinic acid, sulfamic acid, sulfanilic acid, sulfuric acid, tannin, tartaric acid, and p-toluenesulfonic acid, and the inorganic and organic bases are selected from the following: Na, potassium, magnesium, calcium, etc., or amines, diethylamine, triethylamine, ethanolamine, etc.

[0069] The pharmaceutically acceptable salts of the present invention can be synthesized by conventional chemical methods from parent compounds containing acidic or base compounds. Generally, such salts are prepared by reacting these compounds in the form of free acid or base with a stoichiometric amount of a suitable base or acid in water, an organic solvent, or a mixture thereof. Generally, non-aqueous media such as ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred.

[0070] In addition to the salt form, the compounds provided by the present invention also exist in prodrug form. The prodrugs of the compounds described herein readily undergo chemical changes under physiological conditions, thereby being converted into the compounds of the present invention. Furthermore, the prodrugs can be converted into the compounds of the present invention by chemical or biochemical methods in the internal environment.

[0071] Certain compounds of the present invention may exist in non-solvated or solvated forms, including hydrated forms. Generally, solvated forms are equivalent to non-solvated forms, and both are within the scope of the present invention. Certain compounds of the present invention may exist in polymorphic or amorphous forms.

[0072] In this specification, the term "solvate" refers to an aggregate formed by one or more solvent molecules and the compounds of the present invention. Solvents that form solvates include, but are not limited to, water, isopropanol, ethanol, methanol, dimethyl sulfoxide, ethyl acetate, acetic acid, and ethanolamine. Accordingly, the term "hydrate" refers to an aggregate formed by solvent molecules with water.

[0073] Certain compounds of the present invention may have an asymmetric carbon atom (optical center) or a double bond. Racemates, diastereomers, geometric isomers, and individual isomers are all included within the scope of the present invention.

[0074] The methods for illustrating racemic, ambiscalemic, and scalemic or enantiomerically pure compounds herein are from Maehr, J. Chem. Ed. 1985, 62: 114-120. Unless otherwise specified, wedge-shaped and dashed-line bonds are used to represent the absolute configuration of stereocenters. Where compounds described herein contain olefinic double bonds or other geometrically asymmetric centers, unless otherwise specified, they include E, Z geometric isomers. Similarly, all tautomers are also included within the scope of the present invention.

[0075] The compounds of the present invention can exist in specific geometric or stereoisomeric forms. The present invention envisions all compounds, including cis and trans isomers, (-)- and (+)-enantiomers, (R)- and (S)-enantiomers, diastereomers, (D)-isomers, (L)-isomers, and racemic and other mixtures thereof, such as mixtures enriched with enantiomers or diastereomers, and all of these mixtures are within the scope of the present invention. Additional chiral carbon atoms may be present in substituents such as alkyl groups. All of these isomers and mixtures thereof are within the scope of the present invention.

[0076] Optically active (R)- and (S)-isomers, as well as D and L isomers, can be prepared by chiral synthesis, chiral reagents, or other prior art. If one enantiomer of a compound of the present invention is desired, it can be prepared by asymmetric synthesis or derivatization with a chiral auxiliary agent. The resulting diastereomer mixture is then separated, and the auxiliary groups are cleaved to provide the pure, desired enantiomer. Alternatively, if the molecule contains a basic functional group (e.g., an amino group) or an acidic functional group (e.g., a carboxyl group), a salt of the diastereomer is formed with a suitable optically active acid or base, and the diastereomer is then separated by fractional crystallography or chromatography known in the art, and subsequently recovered to obtain the pure enantiomer. Furthermore, the separation of enantiomers and diastereomers is usually achieved using chromatography, which employs a chiral stationary phase and is optionally combined with chemical induction methods (e.g., the production of carbamates from amines).

[0077] The compounds of the present invention may contain unnatural proportions of atomic isotopes on one or more atoms constituting the compound. For example, radioactive isotopes, such as tritium. 3 H), Iodine-125( 125 I) or C-14 ( 14The compound can be labeled with C). All isotopic compositional transformations of the compounds of the present invention, whether radioactive or not, are all within the scope of the present invention.

[0078] The term "pharmaceutically acceptable carrier" refers to any formulation or carrier medium that can deliver an effective amount of the active substance of the present invention, does not interfere with the biological activity of the active substance, and is toxic and free of side effects to the host or patient. Typical carriers include water, oils, vegetable oils and mineral oils, cream bases, lotion bases, ointment bases, etc. These bases include suspending agents, thickeners, transdermal accelerators, etc. These formulations are well known to technicians in the fields of cosmetics or topical drugs. For further information regarding carriers, see Remington: The Science and Practice of Pharmacy, 21st Ed., Lippincott, Williams & Wilkins (2005), the contents of which are incorporated herein by reference.

[0079] If any variable (e.g., R) appears two or more times in the composition or structure of a compound, its definition in each case is independent. Therefore, for example, if a group is substituted with 0 to 2 Rs, the group may be selectively substituted with up to 2 Rs, and each R has an independent choice. Furthermore, combinations of substituents and / or their variants are only permitted if such combinations result in a stable compound.

[0080] If the bond of one substituent can intersect and link to two atoms on a ring, then such substituent can bond to any atom on that ring. If, in the enumerated substituents, it is not indicated which atom it links to in the chemical structure but which is not specifically mentioned, then such substituent can bond to any of its atoms. Combinations of substituents and / or their variants are permissible only if such combinations result in a stable compound.

[0081] The term "halo" or "halogen" refers to fluorine, chlorine, bromine, and iodine.

[0082] The present invention is now further illustrated by examples. The examples shown below are for illustrative purposes only and do not limit the scope of the present invention. The compounds of the present invention can be prepared using many methods known in the field of organic synthesis. The examples of the present invention can be synthesized using the methods described below, as well as synthetic methods known in the field of organic synthesis chemistry, or improved methods based thereon. Preferred methods include, but are not limited to, the methods described below.

[0083] Unless otherwise specified, all solvents used in this invention are commercially available and do not require further purification before use. Reactions are typically carried out using anhydrous solvents under an inert nitrogen atmosphere. Nuclear magnetic resonance spectra are measured with a Bruker-Avance-400 (400 MHz) spectrometer and the chemical shift is reported as δ (ppm). Mass spectra are obtained using an Agilent 1200 series (plus6110 / and 1956A) LC / MS or a Shimadzu MS (DAD:SPD-M20A(LC)) with a Shimadzu Micromass2020 detector. The mass spectrometer is equipped with an electrospray ion source (ESI) operating in positive and negative modes.

[0084] The abbreviations used are as follows: aq = aqueous solution, TLC = thin-layer chromatography, RT = room temperature, MeOH = methanol, EtOH = ethanol, Ã = ethyl acetate, THF = tetrahydrofuran, eq = equivalent, CDI = carbonyldiimidazole, DCM = dichloromethane, PE = petroleum ether, DIAD = diisopropyl azodicarboxylic acid, DMF = N,N-dimethylformamide, DMSO = dimethyl sulfoxide, CBz = benzyloxycarbonyl, BOC = tert-butylcarbon Nyl, HOAc is acetic acid, Ms is a methanesulfonyl group, NMP is N-methylpyrrolidone, DMAP is 4-(dimethylamino)pyridine, Boc2O is di-tert-butyl dicarbonate, TFA is trifluoroacetic acid, DIPEA is diisopropylethylamine, SOCl2 is thionyl chloride, CS2 is carbon disulfide, TsOH is 4-toluenesulfonic acid, MTBE is tert-butyl methyl ether, FA is formic acid, ACN is acetonitrile, and i-PrOH is 2-propanol.

[0085] Compounds can be named manually, using ChemDraw®, or, if purchased commercially, using the supplier's catalog name. Typically, TLC or LC-MS is used to determine if the reaction is complete. [Modes for carrying out the invention]

[0086] To illustrate the present invention in more detail, the following examples are given, but the scope of the present invention is not limited thereto.

[0087] Example 1, Synthesis of (2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)-1-(2,2,2-trifluoroethyl)-1H-indole-4-yl)dimethylphosphine oxide (Compound 1): 1) Synthesis of 4-bromo-1-(phenylsulfonyl)-1H-indole [ka]

[0088] Under 0°C conditions, sodium hydride (918 mg, 22.95 mmol, dispersed in kerosene at a mass fraction of 60%) was added to a 30 mL solution of tetrahydrofuran containing 3.00 g, 15.30 mmol of 4-bromo-1H-indole. After the addition was complete, the mixture was stirred at 0°C for 30 minutes, and then benzenesulfonyl chloride (4.06 g, 22.95 mmol) was added dropwise to the reaction mixture. The resulting reaction mixture was stirred at room temperature for 16 hours. After the reaction was complete, water (40 mL) was added to the reaction mixture to quench it, and the mixture was extracted with ethyl acetate (40 mL x 3). The combined organic layers were washed with brine (10 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 1 / 1) to obtain 4-bromo-1-(phenylsulfonyl)-1H-indole (4.65 g, 13.84 mmol, yield: 90.4%).

[0089] 1 H NMR (400 MHz, CDCl3) δ 7.95 (d, J=8.4 Hz, 1H), 7.88-7.86 (m, 2 H), 7.63 (d, J=3.6 Hz, 1H), 7.55 (t, J=7.2 Hz, 1 H), 7.44 (t, J=8.0 Hz, 2 H), 7.39 (d, J=8.0 Hz, 1 H), 7.17 (t, J=8.0 Hz, 1 H), 6.73 (d, J=3.6 Hz, 1 H).

[0090] 2) Synthesis of 4-bromo-2-iodo-1-(phenylsulfonyl)-1H-indole [ka]

[0091] Under conditions of -78°C, lithium diisopropylamide (9 mL, 17.85 mmol, 2.0 M tetrahydrofuran solution) was added dropwise to a tetrahydrofuran solution (20 mL) containing 4-bromo-1-(phenylsulfonyl)-1H-indole (2.00 g, 5.95 mmol). After the addition was complete, the mixture was stirred at -78°C for 30 minutes, and then iodine (2.27 g, 8.93 mmol) was added to the reaction mixture. The resulting reaction mixture was stirred at room temperature for 16 hours. After the reaction was complete, the mixture was poured into a saturated ammonium chloride solution (30 mL) to quench the reaction, and extracted with ethyl acetate (20 mL x 3). The combined organic layers were washed with saturated brine (10 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 1 / 1) to obtain 4-bromo-2-iodo-1-(phenylsulfonyl)-1H-indole (876 mg, 1.90 mmol, yield: 31.8%).

[0092] 1 H NMR (400 MHz, DMSO-d6) δ 8.19 (d, J=8.4 Hz, 1H), 7.91-7.89 (m, 2 H), 7.75 (t, J=7.6 Hz, 1 H), 7.64 (t, J=8.0 Hz, 2 H), 7.50 (d, J=7.6 Hz, 1 H), 7.23 (t, J=8.0 Hz, 1 H), 7.13 (s, 1 H).

[0093] 3) Synthesis of 4-bromo-2-iodo-1H-indole [ka]

[0094] Under room temperature conditions, potassium carbonate (524 mg, 3.80 mmol) was added to a mixed solution of methanol (20 mL) containing 876 mg, 1.90 mmol of 4-bromo-2-iodo-1-(phenylsulfonyl)-1H-indole (876 mg, 1.90 mmol) and water (2 mL). The resulting reaction mixture was stirred at 80°C for 5 hours. After the reaction was complete, the reaction mixture was concentrated under reduced pressure and purified by silica gel column chromatography (petroleum ether / ethyl acetate = 1 / 1) to obtain 4-bromo-2-iodo-1H-indole (426 mg, 1.32 mmol, yield: 69.8%).

[0095] 1 H NMR (400 MHz, DMSO-d6) δ 12.04 (d, J=0.4 Hz, 1H), 7.33 (d, J=8.4 Hz, 1H), 7.19 (d, J=7.6 Hz, 1H), 6.98 (t, J=7.6 Hz, 1 H), 6.58 (s, 1 H).

[0096] 4) Synthesis of 4-bromo-2-iodo-1-(2,2,2-trifluoroethyl)-1H-indole [ka]

[0097] Under conditions of 0°C, sodium hydride (79 mg, 1.98 mmol, dispersed in kerosene at a mass fraction of 60%) was added to a 10 mL solution of N,N-dimethylformamide containing 4-bromo-2-iodo-1H-indole (426 mg, 1.32 mmol). The resulting reaction mixture was stirred at 0°C for 30 minutes, and then 2,2,2-trifluoroethyl trifluoromethanesulfonic acid (367 mg, 1.58 mmol) was added to the above mixture. After the addition was complete, the resulting reaction mixture was stirred at room temperature for 16 hours. After the reaction was complete, water (10 mL) was added to the reaction mixture to quench it, and it was extracted with ethyl acetate (20 mL x 3). The combined organic phase was washed with saturated brine (10 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 40 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 40 mL / min; gradient: 40%B to 95%B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 82%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain 4-bromo-2-iodo-1-(2,2,2-trifluoroethyl)-1H-indole (485 mg, 1.20 mmol, yield: 90.8%).

[0098] 1 H NMR (400 MHz, DMSO-d6) δ 7.69 (d, J=8.4 Hz, 1H), 7.31 (d, J=7.6 Hz, 1 H), 7.11 (t, J=8.4 Hz, 1 H), 6.85 (s, 1 H), 5.23-5.16 (m, 2 H).

[0099] 5) Synthesis of N-(3-(4-bromo-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl)-2-methoxy-4-(methylsulfonyl)aniline [ka]

[0100] Under room temperature conditions, 4-bromo-2-iodo-1-(2,2,2-trifluoroethyl)-1H-indole (485 mg, 1.20 mmol) and 2-methyl-4-(methylsulfinyl)-N-(propa-2-in-1-yl)aniline (574 mg, 2.40 mmol) were dissolved in dimethyl sulfoxide (10 mL). Diethylamine (876 mg, 12.00 mmol), copper(I) iodide (46 mg, 0.24 mmol), and tetrakis(triphenylphosphine)palladium (139 mg, 0.12 mmol) were added to this solution. The resulting reaction mixture was stirred at 25°C for 4 hours under nitrogen protection. After the reaction was complete, water (10 mL) was added to the reaction mixture to quench it, and the mixture was extracted with ethyl acetate (20 mL x 3). The combined organic phase was washed with saturated brine (10 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 1 / 1) to obtain N-(3-(4-bromo-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl)-2-methoxy-4-(methylsulfonyl)aniline (480 mg, 0.93 mmol, yield 77.6%).

[0101] 1 H NMR (400 MHz, DMSO-d6) δ 7.61 (d, J=8.4 Hz, 1H), 7.41-7.35 (m, 2 H), 7.26-7.19 (m, 2 H), 6.92 (d, J=8.0 Hz, 1 H), 6.76(s, 1 H), 6.52(t, J=6.4 Hz, 1 H), 5.15-5.08 (m, 2 H), 4.39 (d, J=6.0 Hz, 2 H), 3.90 (s, 3 H), 3.09 (s, 3 H).

[0102] 6) Synthesis of (2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)-1-(2,2,2-trifluoroethyl)-1H-indole-4-yl)dimethylphosphine oxide [ka]

[0103] Under room temperature conditions, N-(3-(4-bromo-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl)-2-methoxy-4-(methylsulfonyl)aniline (100 mg, 0.19 mmol) and dimethylphosphine oxide (20 mg, 0.25 mmol) were dissolved in N,N-dimethylformamide (10 mL). Potassium phosphate (54 mg, 0.25 mmol), palladium acetate (4 mg, 0.024 mmol), and 4,5-bis(diphenylphosphin)-9,9-dimethylxanthene (12 mg, 0.021 mmol) were added to this solution. After the additions were complete, the resulting reaction mixture was heated to 120 °C under nitrogen protection and stirred for 5 hours. After the reaction was complete, the reaction mixture was concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 40 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 40 mL / min; gradient: 30%B to 80%B within 20 minutes; detector: 254 nm). When the content of mobile phase B reached 46%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain (2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)-1-(2,2,2-trifluoroethyl)-1H-indole-4-yl)dimethylphosphine oxide (compound 1) (46.92 mg, 0.09 mmol, yield: 47.3%). LCMS m / z: 513 [M+H] + .

[0104] 1H NMR (400 MHz, DMSO-d6) δ 7.78 (d, J=8.4 Hz, 1H), 7.54-7.49 (m, 1 H), 7.41-7.36 (m, 2 H), 7.26-7.23 (m, 2 H), 6.91 (d, J=8.4 Hz, 1 H), 6.51 (t, J=6.0 Hz, 1 H), 5.18-5.12 (m, 2 H), 4.40 (d, J=6.4 Hz, 2 H), 3.90 (s, 3 H), 3.09 (s, 3 H), 1.72 (s, 3 H), 1.69 (s, 3 H).

[0105] Example 2, Synthesis of 1-Cyclopropyl-N-((3S,4R)-3-Fluoropiperidine-4-yl)-2-(3-((2-Methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)-1H-Indole-4-amine or 1-Cyclopropyl-N-((3R,4S)-3-Fluoropiperidine-4-yl)-2-(3-((2-Methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)-1H-Indole-4-amine (Compounds 2A and 2B): 1) Synthesis of 1-cyclopropyl-2-iodo-4-nitro-1H-indole: [ka]

[0106] Under room temperature conditions, 2-iodo-4-nitro-1H-indole (2.00 g, 6.94 mmol) was dissolved in toluene (50 mL) solution. Copper acetate (1.26 g, 6.94 mmol), 4-dimethylaminopyridine (2.54 g, 20.82 mmol), and cyclopropylboronic acid (1.19 g, 13.88 mmol) were added. After the additions were complete, the resulting reaction mixture was gas-purged three times with oxygen to maintain an oxygen environment. Then, sodium bis(trimethylsilyl)amide (6.94 mmol, 3.47 mL, 2 M) was added. After the additions were complete, the resulting reaction mixture was heated to 100°C and stirred for 16 hours. After the reaction was complete, the reaction mixture was quenched with saturated ammonium chloride aqueous solution (100 mL) and extracted with ethyl acetate (50 mL x 5). The combined organic layers were washed with saturated brine (50 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 330 g; mobile phase A: pure water containing 0.1% formic acid; mobile phase B: acetonitrile; flow rate: 120 mL / min; gradient: 5%B to 95%B within 40 minutes; detector: 254 nm). When the content of mobile phase B reached 80%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain 1-cyclopropyl-2-iodo-4-nitro-1H-indole (1.03 g, 3.14 mmol, yield: 45.3%). LCMS m / z: 329 [M+H] + .

[0107] 2) Synthesis of 1-cyclopropyl-2-iodo-1H-indole-4-amine: [ka]

[0108] Under room temperature conditions, a mixture of ethanol (20 mL) containing 1-cyclopropyl-2-iodo-4-nitro-1H-indole (1.18 g, 3.60 mmol) and water (2 mL) was mixed with iron powder (2.02 g, 36.00 mmol) and ammonium chloride (1.91 g, 36.00 mmol). After the addition was complete, the resulting reaction mixture was heated to 80°C and stirred for 1 hour. The completion of the reaction was detected by LC-MS and TLC, and the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 3 / 1) to obtain 1-cyclopropyl-2-iodo-1H-indole-4-amine (900 mg, 3.02 mmol, yield: 83.9%). LC-MS m / z: 299 [M+H] + .

[0109] 3) Synthesis of 4-((1-cyclopropyl-2-iodo-1H-indole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl: [ka]

[0110] Under room temperature conditions, 1-cyclopropyl-2-iodo-1H-indole-4-amine (900 mg, 3.02 mmol) was dissolved in a mixed solution of 1,2-dichloroethane (5 mL) and acetic acid (15 mL). To this mixture, 3-fluoro-4-oxopiperidine-1-carboxylate tert-butyl (3.28 g, 15.10 mmol) and sodium triacetoxyborohydride (1.60 g, 7.55 mmol) were added. After the addition was complete, the resulting reaction mixture was heated to 40°C and stirred for 2 hours. After the reaction was complete, the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 4 / 1) to obtain 4-((1-cyclopropyl-2-iodo-1H-indole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl (860 mg, 1.72 mmol, yield: 57.0%). LCMS m / z: 500 [M+H] + .

[0111] 4) Synthesis of 4-((1-cyclopropyl-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)prop-1-in-1-yl)-1H-indole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl: [ka]

[0112] Under room temperature conditions, 4-((1-cyclopropyl-2-iodo-1H-indole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl (810 mg, 1.62 mmol) was dissolved in dimethyl sulfoxide (10 mL) solution, to which 2-methoxy-4-(methylsulfonyl)-N-(propa-2-in-1-yl)aniline (774 mg, 3.24 mmol), diethylamine (1.18 g, 16.20 mmol), copper(I) iodide (61 mg, 0.32 mmol), and tetrakis(triphenylphosphine)palladium (185 mg, 0.16 mmol) were added. The mixture was stirred at 25°C for 16 hours. After the reaction was complete, water (30 mL) was added to the reaction mixture to quench it, and the mixture was extracted with ethyl acetate (20 mL x 3). The combined organic layers were washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 120 g; mobile phase A: aqueous solution containing 0.1% formic acid; mobile phase B: acetonitrile; flow rate: 80 mL / min; gradient: 5% B to 95% B within 35 minutes; detector: 254 nm). When the content of mobile phase B reached 80%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain 4-((1-cyclopropyl-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propane-1-in-1-yl)-1H-indole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl (700 mg, 1.15 mmol, yield: 70.6%). LCMS m / z: 611[M+H] + .

[0113] 5) Synthesis of (3R,4S)-4-((1-cyclopropyl-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)prop-1-in-1-yl)-1H-indole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl and (3S,4R)-4-((1-cyclopropyl-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)prop-1-in-1-yl)-1H-indole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl: [ka]

[0114] 4-((1-cyclopropyl-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)prop-1-in-1-yl)-1H-indole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl (700 mg, 1.15 mmol) was purified by supercritical fluid chromatography (chromatographic conditions: System: Waters SFC 150, DAIEL CHIRALPAK® IB 250×25 mm 10 μm, Mobile phase A: Supercritical CO2, Mobile phase B: MeOH (+0.1% 7.0 mol / l Ammonia in MeOH), A:B: 55:45, Flow rate: 100 mL / min, Detection wavelength: 214 nm, Column pressure: RT, Column pressure: 100 bar) to obtain two isomers, namely C101-203-A-1 and C101-203-B.

[0115] C101-203-A-1: Peak 1: 2.676 min (240 mg, 0.39 mmol, yield: 34.3%)

[0116] C101-203-B-9: Peak 2: 3.368 min (270 mg, 0.44 mmol, yield: 38.6%).

[0117] 6) Synthesis of 1-cyclopropyl-N-((3R,4S)-3-fluoropiperidine-4-yl)-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)-1H-indole-4-amine or 1-cyclopropyl-N-((3S,4R)-3-fluoropiperidine-4-yl)-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)-1H-indole-4-amine (compounds 2A and 2B) [ka]

[0118] Under room temperature conditions, 2,6-dimethylpyridine (106 mg, 0.99 mmol) and iodotrimethylsilane (198 mg, 0.99 mmol) were added to dichloromethane (3 mL) containing the C101-203-A-1 isomer (20 mg, 0.033 mmol). After the addition was complete, the resulting reaction mixture was stirred at room temperature for 1 hour. After the reaction was complete, the reaction mixture was diluted with dichloromethane (50 mL), then washed with saturated sodium sulfite (15 mL) and saturated brine (20 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by silica gel column chromatography (dichloromethane / methanol = 15 / 1) to obtain 1-cyclopropyl-N-((3S,4R)-3-fluoropiperidine-4-yl)-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)-1H-indole-4-amine or 1-cyclopropyl-N-((3R,4S)-3-fluoropiperidine-4-yl)-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)-1H-indole-4-amine (compound 2A) (5.26 mg, 0.010 mmol, yield 31.4%). LCMS m / z: 511 [M+H] + .

[0119] 1H NMR (400 MHz, CD3OD) δ 7.50 (dd, J=8.4 Hz, 2.0 Hz 1 H), 7.31 (d, J=1.6 Hz 1 H), 7.04 (t, J=8.0 Hz, 1 H), 6.97 (d, J=8.0 Hz 1 H), 6.91 (d, J=8.0 Hz, 1 H), 6.76 (s, 1 H), 6.33 (d, J=7.6 Hz, 1 H), 4.90-4.78 (m, 1 H), 4.38 (s, 2 H), 3.97 (s, 3 H), 3.82-3.60 (m, 2 H), 3.19-3.15 (m, 1 H), 3.10-3.06 (m, 4 H), 3.03-2.89 (m, 1 H), 2.86-2.80 (m, 1 H), 1.96-1.84 (m, 2 H), 1.02-0.92 (m, 4 H).

[0120] Under room temperature conditions, 2,6-dimethylpyridine (995 mg, 9.30 mmol) and iodotrimethylsilane (1860 mg, 9.30 mmol) were added to a 10 mL solution of dichloromethane containing C101-203-B-9. After the addition was complete, the resulting reaction mixture was stirred at room temperature for 2 hours. After the reaction was complete, the reaction mixture was concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatography conditions: column: spherical C18, 20-40 μm, 120 g, mobile phase A: pure water containing 0.1% NH3·H2O, mobile phase B: acetonitrile, flow rate: 80 mL / min, gradient: 5%B to 95%B within 40 minutes, detector: 254 nm) to obtain the crude product (136 mg). The crude product was again subjected to preparative high-performance liquid chromatography (chromatography conditions: Waters 2762 / Qda, column: Sunfire). Purified by C18, 19×250mm, 10μm, mobile phase A: pure water containing 0.1% formic acid, mobile phase B: acetonitrile, flow rate: 20mL / min, gradient: 27%-27%, retention time: 7.4-9.5min within 16 minutes), and 1-cyclopropyl-N-((3R,4S)-3-fluoropiperidine-4-yl)-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino )propa-1-in-1-yl)-1H-indole-4-amine or 1-cyclopropyl-N-((3S,4R)-3-fluoropiperidine-4-yl)-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)-1H-indole-4-amine (compound 2B) (24.35 mg, 0.048 mmol, yield: 15.1%) was obtained. LCMS m / z: 511[M+H] + .

[0121] 1H NMR (400 MHz, CD3OD) δ 7.46 (dd, J=8.4 Hz, 2.0 Hz 1H), 7.28 (d, J=2.0 Hz 1H), 7.01 (t, J=8.0 Hz, 1 H), 6.92 (d, J=8.4 Hz 1H), 6.86 (d, J=8.0 Hz, 1 H), 6.72 (s, 1 H), 6.29 (d, J=7.6 Hz, 1 H), 4.70 (s, 1 H), 4.34 (s, 2 H), 3.92 (s, 3 H), 3.76-3.65 (m, 1 H), 3.31-3.24 (m, 1 H), 3.10-3.03 (m, 5H), 2.91-2.69(m, 2 H), 1.89-1.72 (m, 2 H), 0.96-0.91 (m, 4 H).

[0122] Example 3, Synthesis of (3S,4R)-3-fluoro-N-(2-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[b]thiophen-4-yl)piperidine-4-amine (Compound 3): 1) Synthesis of 4-bromo-2-iodobenzo[b]thiophene [ka]

[0123] Under conditions of -78°C, lithium diisopropylamide (35.21 mmol, 18 mL, 2 M) solution was added dropwise to a tetrahydrofuran (50 mL) solution containing 4-bromobenzo[b]thiophene (5.00 g, 23.47 mmol). After the addition was complete, the resulting reaction mixture was stirred at -78°C for 30 minutes, and then iodine (7.15 g, 28.16 mmol) was added to the above mixture. After the addition was complete, the resulting mixed reaction mixture was stirred at room temperature for 5 hours. After the reaction was complete, the reaction mixture was poured into saturated ammonium chloride solution (50 mL) and quenched, and extracted with ethyl acetate (50 mL x 3). The organic phases were combined and washed with saturated brine (20 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 330 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 120 mL / min; gradient: 40%B to 100%B within 20 minutes; detector: 214 nm). When the mobile phase content reached 99%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain 4-bromo-2-iodobenzo[B]thiophene (2.14 g, 6.31 mmol, yield: 26.8%).

[0124] 1 H NMR (400 MHz, DMSO-d6) δ 8.02 (d, J=8.0 Hz, 1H), 7.71 (d, J=0.8 Hz, 1H), 7.61 (dd, J=8.0 Hz, 0.8 Hz, 1 H), 7.29 (t, J=8.0 Hz, 1 H).

[0125] 2) Synthesis of (3-(4-bromobenzo[b]thiophen-2-yl)propa-2-in-1-yl)(2-methoxy-4-(methylsulfonyl)phenyl)carbamate tert-butyl: [ka]

[0126] Under room temperature conditions, 4-bromo-2-iodobenzo[b]thiophene (200 mg, 0.59 mmol) and (2-methoxy-4-(methylsulfonyl)phenyl)(propa-2-in-1-yl)carbamate tert-butyl were dissolved in dimethyl sulfoxide (10 mL) solution. Diethylamine (431 mg, 5.90 mmol), copper(I) iodide (23 mg, 0.12 mmol), and tetrakis(triphenylphosphine)palladium (69 mg, 0.059 mmol) were added to this solution. After the additions were complete, the resulting reaction mixture was stirred under nitrogen protection at 25°C for 2 hours. After the reaction was complete, water (10 mL) was added to the reaction mixture to quench it, and the mixture was extracted with ethyl acetate (20 mL x 3). The combined organic phase was washed with saturated brine (10 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 80 g; mobile phase A: pure water containing 0.1% NH3H2O; mobile phase B: acetonitrile; flow rate: 80 mL / min; gradient: 40% B to 100% B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 98%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain (3-(4-bromobenzo[b]thiophen-2-yl)propa-2-in-1-yl)(2-methoxy-4-(methylsulfonyl)phenyl)carbamate tert-butyl (260 mg, 0.47 mmol, yield: 80.2%). LCMS m / z: 494 [M+H-56] + .

[0127] 3) Synthesis of (3S,4R)-4-((2-(3-((tert-butoxycarbonyl)(2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[b]thiophen-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl: [ka]

[0128] Under room temperature conditions, cesium carbonate (1.17 g) was added to a 10 mL solution of dioxane containing (3-(4-bromobenzo[b]thiophen-2-yl)propa-2-in-1-yl)(2-methoxy-4-(methylsulfonyl)phenyl)carbamate tert-butyl (200 mg, 0.36 mmol) and (3S,4R)-4-amino-3-fluoropiperidine-1-carboxylate tert-butyl (78 mg, 0.36 mmol). 3.60 mmol) of methanesulfonic acid (2-dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) (36 mg, 0.04 mmol, 0.1 equivalent) and 2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl (16 mg, 0.04 mmol) were added. After the addition was complete, the resulting reaction mixture was heated to 90°C under nitrogen protection and stirred for 2 hours. After the reaction was complete, the reaction mixture was concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 80 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 80 mL / min; gradient: 40% B to 100% B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 95%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain (3S,4R)-4-((2-(3-((tert-butoxycarbonyl)(2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[b]thiophen-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl (120 mg, 0.17 mmol, yield: 48.0%). LCMS m / z: 688 [M+H] + .

[0129] 4) Synthesis of (3S,4R)-3-fluoro-N-(2-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[b]thiophen-4-yl)piperidine-4-amine (compound 3): [ka]

[0130] (3S,4R)-4-((2-(3-((tert-butoxycarbonyl)(2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[b]thiophen-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl (50 mg, 0.072 mmol) was dissolved in a 10 mL solution of dichloromethane, to which 2,6-dimethylpyridine (225 mg, 2.10 mmol) and trimethylsilyl iodide (420 mg, 2.10 mmol) were added. After the addition was complete, the resulting reaction mixture was stirred at room temperature for 1 hour. After the reaction was complete, the reaction mixture was concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 40 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 40 mL / min; gradient: 40%B to 95%B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 76%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain (3S,4R)-3-fluoro-N-(2-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[b]thiophen-4-yl)piperidine-4-amine (compound 3) (12.57 mg, 0.026 mmol, yield: 35.4%). LCMS m / z: 488 [M+H] + .

[0131] 1H NMR (400 MHz, DMSO-d6) δ 8.04 (s, 1 H), 7.41 (d, J=8.4 Hz, 1 H), 7.25 (s, 1 H), 7.16 (t, J=8.0 Hz, 1 H), 7.06 (d, J=7.6 Hz, 1 H), 6.84 (d, J=8.4 Hz, 1 H), 6.54 (d, J=7.6 Hz, 1 H), 6.48 (t, J=6.0 Hz, 1 H), 5.82 (d, J=8.0 Hz, 1 H), 4.76-4.64 (m, 1 H), 4.34 (d, J=6.0 Hz, 2 H), 3.90 (s, 3H), 3.73-3.63 (m, 1 H), 3.14-3.11 (m, 4 H), 2.99-2.96 (m, 1 H), 2.89-2.67 (m, 1 H), 2.62-2.55 (m, 1 H), 1.82-1.60 (m, 2 H).

[0132] Example 4, Synthesis of (S)-(4-((3-(4-((6,6-dimethylpiperidine-3-yl)amino)-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl)amino)-3-methoxyphenyl)dimethylphosphine oxide (Compound 4): 1) Synthesis of (4-amino-3-methoxyphenyl)dimethylphosphine oxide: [ka]

[0133] Under room temperature conditions, potassium phosphate (6.89 g, 32.18 mmol), palladium acetate (412 mg, 2.48 mmol), and 4,5-bisdiphenylphosphin-9,9-dimethylxanthene (1.44 g, 2.48 mmol) were added to a 50 mL solution of N,N-dimethylformamide containing 5.00 g, 24.75 mmol, and dimethylphosphine oxide (2.51 g, 32.18 mmol). After the additions were complete, the resulting reaction mixture was heated to 150 °C under nitrogen protection and stirred for 5 hours. After the reaction was complete, water (50 mL) was added to the reaction mixture to quench it, and the mixture was extracted with ethyl acetate (50 mL x 5). The combined organic layers were washed with saturated ammonium chloride solution (50 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 330 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 150 mL / min; gradient: 20%B to 95%B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 31%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain (4-amino-3-methoxyphenyl)dimethylphosphine oxide (1.90 g, 9.55 mmol, yield: 38.5%). LCMS m / z: 200 [M+H] + .

[0134] 2) Synthesis of tert-butyl (4-(dimethylphosphoryl)-2-methoxyphenyl)carbamate: [ka]

[0135] Under room temperature conditions, triethylamine (2.89 g, 28.65 mmol), 4-dimethylaminopyridine (1.17 g, 9.55 mmol), and di-tert-butyl dicarbonate (2.08 g, 9.55 mmol) were added to a 20 mL solution of dichloromethane containing (4-amino-3-methoxyphenyl)dimethylphosphine oxide. After the additions were complete, the resulting reaction mixture was stirred at room temperature for 16 hours. After the reaction was complete, the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 1 / 1) to obtain (4-(dimethylphosphoryl)-2-methoxyphenyl)carbamate tert-butyl (630 mg, 2.11 mmol, yield: 22.0%). LCMS m / z: 300 [M+H] + .

[0136] 3) Synthesis of (4-(dimethylphosphoryl)-2-methoxyphenyl)(propa-2-in-1-yl)carbamate tert-butyl: [ka]

[0137] To a 5 mL solution of N,N-dimethylformamide containing tert-butyl (4-(dimethylphosphoryl)-2-methoxyphenyl)carbamate (200 mg, 0.67 mmol), cesium carbonate (655 mg, 2.01 mmol) and 3-bromopropa-1-yne (95 mg, 0.80 mmol) were added. After the addition was complete, the resulting reaction mixture was heated to 80°C and stirred for 3 hours. After the reaction was complete, the resulting mixture was filtered and concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 120 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 80 mL / min; gradient: 5%B to 95%B within 20 minutes; detector: 254 nm). When the content of mobile phase B reached 53%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain (4-(dimethylphosphoryl)-2-methoxyphenyl)(propa-2-in-1-yl)carbamate tert-butyl (180 mg, 0.53 mmol, yield: 80.0%). LCMS m / z: 338 [M+H] + .

[0138] 4) Synthesis of (3-(4-bromo-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl)(4-(dimethylphosphoryl)-2-methoxyphenyl)carbamate tert-butyl: [ka]

[0139] Under room temperature conditions, triethylamine (253 mg, 2.50 mmol), copper(I) iodide (10 mg, 0.052 mmol), and tetrakis(triphenylphosphine)palladium (35 mg, 0.03 mmol) were added to a dimethyl sulfoxide (3 mL) solution containing tert-butyl (4-(dimethylphosphoryl)-2-methoxyphenyl)(propa-2-in-1-yl) and 4-bromo-2-iodo-1-(2,2,2-trifluoroethyl)-1H-indole (202 mg, 0.50 mmol). After the additions were complete, the resulting reaction mixture was stirred under nitrogen protection at 25°C for 2 hours. After the reaction was complete, the reaction mixture was quenched with water (3 mL) and extracted with ethyl acetate (10 mL x 3). The combined organic phases were washed with saturated saline solution (10 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 120 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 80 mL / min; gradient: 40%B to 100%B over 20 minutes; detector: 214 nm). When the content of mobile phase B reached 82%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain (3-(4-bromo-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl)(4-(dimethylphosphoryl)-2-methoxyphenyl)carbamate tert-butyl (260 mg, 0.42 mmol, yield: 85.2%). LCMS m / z: 613[M+H] + .

[0140] 5) Synthesis of (S)-(4-(dimethylphosphoryl)-2-methoxyphenyl)(3-(4-((6,6-dimethylpiperidine-3-yl)amino)-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl) tert-butyl carbamate: [ka]

[0141] Under room temperature conditions, cesium carbonate (1) was added to a 5 mL solution of dioxane containing tert-butyl (3-(4-bromo-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl)(4-(dimethylphosphoryl)-2-methoxyphenyl)carbamate and (S)-6,6-dimethylpiperidine-3-amine hydrochloride (61 mg, 0.37 mmol). 0.11 g, 3.40 mmol) of methanesulfonic acid (2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) (27 mg, 0.03 mmol) and 2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl (14 mg, 0.03 mmol) were added. After the addition was complete, the resulting reaction mixture was heated to 90°C under nitrogen protection and stirred for 2 hours. After the reaction was complete, the reaction mixture was filtered and concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 120 g; mobile phase A: pure water containing 0.1% formic acid; mobile phase B: acetonitrile; flow rate: 80 mL / min; gradient: 40% B to 100% B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 51%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain (S)-(4-(dimethylphosphoryl)-2-methoxyphenyl)(3-(4-((6,6-dimethylpiperidine-3-yl)amino)-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl) tert-butyl carbamate (60 mg, 0.09 mmol, yield: 26.5%). LCMS m / z: 661 [M+H] + .

[0142] 6) Synthesis of (S)-(4-((3-(4-((6,6-dimethylpiperidine-3-yl)amino)-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl)amino)-3-methoxyphenyl)dimethylphosphine oxide (compound 4): [ka]

[0143] (S)-(4-(dimethylphosphoryl)-2-methoxyphenyl)(3-(4-((6,6-dimethylpiperidine-3-yl)amino)-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl) tert-butyl carbamate (60 mg, 0.09 mmol) was dissolved in dichloromethane (5 mL), to which 2,6-dimethylpyridine (289 mg, 2.70 mmol) and iodotrimethylsilane (540 mg, 2.70 mmol) were added. After the addition was complete, the resulting reaction mixture was stirred at room temperature for 1 hour. After the reaction was complete, the reaction mixture was concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 40 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 40 mL / min; gradient: 40%B to 95%B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 73%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain (S)-(4-((3-(4-((6,6-dimethylpiperidine-3-yl)amino)-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl)amino)-3-methoxyphenyl)dimethylphosphine oxide (compound 4) (14.42 mg, 0.026 mmol, yield: 28.3%). LCMS m / z: 561 [M+H] + .

[0144] 1H NMR (400 MHz, DMSO-d6) δ 7.23-7.18 (m, 1 H), 7.15-7.12 (m, 1 H), 7.05 (s, 1 H), 7.00 (t, J=8.0 Hz, 1 H), 6.84 (dd, J=8.4 Hz, 3.2 Hz, 1 H), 6.69 (d, J=8.4 Hz, 1 H), 6.17 (d, J=8.0 Hz, 1 H), 6.03 (t, J=6.4 Hz, 1 H), 5.49 (d, J=8.0 Hz, 1 H), 4.93-4.86 (m, 2 H), 4.31 (d, J=6.4 Hz, 2 H), 3.85 (s, 3 H), 3.43-3.35 (m, 2 H), 3.00-2.98 (m, 1 H), 2.62-2.56 (m, 1 H), 1.83-1.80 (m, 1 H), 1.66-1.52 (m, 8 H), 1.42-1.36 (m, 1 H), 1.10 (d, J=8.4 Hz, 6 H).

[0145] 19 F NMR (400 MHz, DMSO-d6) δ -69.18; 31 P NMR (400 MHz, DMSO-d6) δ 31.94.

[0146] Example 5, Synthesis of N-((3S,4R)-3-fluoropiperidine-4-yl)-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[d]oxazole-4-amine (Compound 5): 1) Synthesis of (3S,4R)-4-(benzo[d]oxazole-4-ylamino)-3-fluoropiperidine-1-carboxylate tert-butyl [ka]

[0147] Under room temperature conditions, cesium carbonate (8.25 g, 25.30 mmol), methanesulfonic acid (2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) (227 mg, 0.25 mmol), and 2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl (117 mg, 0.25 mmol) were added to a 30 mL solution of dioxane containing 4-bromobenzo[d]oxazole (500 mg, 2.53 mmol) and (3S,4R)-4-amino-3-fluoropiperidine-1-carboxylate tert-butyl (663 mg, 3.04 mmol). The resulting reaction mixture was heated to 90°C under nitrogen protection and stirred for 3 hours. The reaction mixture was concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 120 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 80 mL / min; gradient: 30%B to 95%B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 63%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain (3S,4R)-4-(benzo[d]oxazole-4-ylamino)-3-fluoropiperidine-1-carboxylate tert-butyl (200 mg, 0.60 mmol, yield: 23.6%). LCMS m / z: 336 [M+H] + .

[0148] 2) Synthesis of (3S,4R)-3-fluoro-4-((2-iodobenzo[d]oxazole-4-yl)amino)piperidine-1-carboxylate tert-butyl: [ka]

[0149] Under room temperature conditions, a solution of (3S,4R)-4-(benzo[d]oxazole-4-ylamino)-3-fluoropiperidine-1-carboxylate tert-butyl (200 mg, 0.60 mmol) in N,N-dimethylformamide (10 mL) was added to a solution of 1,1,1,2,2,3,3,4,4-nonafluoro-4-iodobutane (415 mg, 1.20 mmol) and sodium tert-butoxide (173 mg, 1.80 mmol) in N,N-dimethylformamide (10 mL). The resulting mixed reaction was stirred at room temperature for 30 minutes. The resulting mixed reaction was quenched with saturated ammonium chloride solution (20 mL) and extracted with ethyl acetate (20 mL x 3). The combined organic phases were washed with saturated ammonium chloride (20 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 120 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 80 mL / min; gradient: 30%B to 95%B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 76%, the fraction containing the product was collected and concentrated under reduced pressure to obtain (3S,4R)-3-fluoro-4-((2-iodobenzo[d]oxazole-4-yl)amino)piperidine-1-carboxylate tert-butyl (150 mg, 0.33 mmol, yield: 54.5%). LCMS m / z: 462 [M+H] + .

[0150] 3) Synthesis of (3S,4R)-4-((2-(3-((tert-butoxycarbonyl)(2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[d]oxazole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl: [ka]

[0151] Under room temperature conditions, (3S,4R)-3-fluoro-4-((2-iodobenzo[d]oxazole-4-yl)amino)piperidine-1-carboxylate tert-butyl (50 mg, 1.11 mmol) and (2-methoxy-4-(methylsulfonyl)phenyl)(propa-2-in-1-yl)carbamate tert-butyl (75 mg, 0.22 mmol) were dissolved in triethylamine (10 mL). Copper(I) iodide (4 mg, 0.02 mmol) and bis(triphenylphosphine)palladium(II) dichloride (8 mg, 0.011 mmol) were added to this solution. The resulting reaction mixture was stirred at 30°C for 3 hours under nitrogen protection. Water (5 mL) was added to the reaction mixture to quench it, and the mixture was extracted with ethyl acetate (10 mL x 3). The combined organic phases were washed with saturated brine (10 mL x 2), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 120 g; mobile phase A: 0.1% NH3·H2O water; mobile phase B: acetonitrile; flow rate: 80 mL / min; gradient: 30%B to 95%B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 68%, the fraction containing the product was collected and concentrated under reduced pressure to obtain (3S,4R)-4-((2-(3-((tert-butoxycarbonyl)(2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[d]oxazole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl (30 mg, 0.04 mmol, yield: 41.1%). LCMS m / z: 673 [M+H] + .

[0152] 4) Synthesis of N-((3S,4R)-3-fluoropiperidine-4-yl)-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[d]oxazole-4-amine (compound 5): [ka]

[0153] (3S,4R)-4-((2-(3-((tert-butoxycarbonyl)(2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[d]oxazole-4-yl)amino)-3-fluoropiperidine-1-carboxylate tert-butyl (30 mg, 0.045 mmol) was dissolved in dichloromethane (7 mL), to which 2,6-dimethylpyridine (128 mg, 1.20 mmol) and iodotrimethylsilane (240 mg, 1.20 mmol) were added. The resulting reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 40 g; mobile phase A: pure water containing 0.1% NH3·H2O; mobile phase B: acetonitrile; flow rate: 40 mL / min; gradient: 40%B to 95%B within 20 minutes; detector: 214 nm). When the content of mobile phase B reached 47%, the fraction containing the product was collected and then concentrated under reduced pressure to obtain N-((3S,4R)-3-fluoropiperidine-4-yl)-2-(3-((2-methoxy-4-(methylsulfonyl)phenyl)amino)propa-1-in-1-yl)benzo[d]oxazole-4-amine (compound 5) (6.49 mg, 0.014 mmol, yield: 30.7%). LCMS m / z: 473 [M+H] + .

[0154] 1H NMR (400 MHz, DMSO-d6) δ 7.43 (d, J=8.0 Hz, 1 H), 7.27 (s, 1 H), 7.19 (t, J=8.0 Hz, 1 H), 6.88-6.81 (m, 2 H), 6.66 (d, J=8.0 Hz, 1 H), 6.59 (t, J=5.6 Hz, 1 H), 5.71 (d, J=8.8 Hz, 1 H), 4.75-4.62 (m, 1 H), 4.42 (d, J=6.0 Hz, 2 H), 4.05-3.9 (m, 1 H), 3.91 (s, 3 H), 3.17-3.12 (m, 1 H), 3.09 (s, 3 H), 2.97-2.94 (m, 1 H), 2.82-2.58 (m, 3 H), 1.67-1.63 (m, 2 H).

[0155] 19 F NMR (400 MHz, DMSO-d6) δ -203.696

[0156] Example 6: Synthesis of (7-((3-((4-((3S,4R)-3-fluoropiperidine-4-yl)amino)-1-(2,2,2-trifluoroethyl)-1H-indole-2-yl)propa-2-in-1-yl)amino)-2,3-dihydrobenzofuran-4-yl)dimethylphosphine oxide (Compound 6) 1) Synthesis of (4-bromo-2,3-dihydrobenzofuran-7-yl)carbamate tert-butyl [ka]

[0157] A tetrahydrofuran (10 mL) solution containing 4-bromo-2,3-dihydrobenzofuran-7-amine (576 mg, 2.69 mmol) and di-tert-butyl dicarbonate (1.47 g, 6.73 mmol) was heated to 70°C and stirred for 16 hours. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 8 / 1) to obtain (4-bromo-2,3-dihydrobenzofuran-7-yl)carbamate tert-butyl (880 mg, crude product). LCMS m / z: 301 [M+H-56+41] + .

[0158] 2) Synthesis of (7-amino-2,3-dihydrobenzofuran-4-yl)dimethylphosphine oxide [ka]

[0159] Under room temperature conditions, tert-butyl (4-bromo-2,3-dihydrobenzofuran-7-yl)carbamate (830 mg, 2.64 mmol) and dimethylphosphine oxide (412 mg, 5.28 mmol) were dissolved in a 10 mL solution of N,N-dimethylformamide. Potassium phosphate (1.68 g, 7.92 mmol), 4,5-bis(diphenylphosphin)-9,9-dimethylxanthene (151 mg, 0.26 mmol), and palladium acetate (43 mg, 0.26 mmol) were added to this solution. The resulting reaction mixture was heated to 120°C under nitrogen protection and stirred for 16 hours. The reaction mixture was diluted with water (100 mL) and extracted with ethyl acetate (100 mL x 2). The combined organic phase was concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 120 g; mobile phase A: pure water containing 0.1% formic acid; mobile phase B: acetonitrile; flow rate: 85 mL / min; gradient: 5%B to 95%B within 30 minutes; detector: 254 nm). When the content of mobile phase B reached 43%, the fraction containing the product was collected and concentrated under reduced pressure to obtain (7-amino-2,3-dihydrobenzofuran-4-yl)dimethylphosphine oxide (760 mg, crude product). LCMS m / z: 212 [M+H] + .

[0160] 3) Synthesis of tert-butyl (4-(dimethylphosphoryl)-2,3-dihydrobenzofuran-7-yl)carbamate [ka]

[0161] A tetrahydrofuran (10 mL) solution containing (7-amino-2,3-dihydrobenzofuran-4-yl)dimethylphosphine oxide (660 mg, 3.13 mmol) and di-tert-butyl dicarbonate (1.71 g, 7.83 mmol) was heated to 70°C and stirred for 16 hours. The mixed reaction solution was concentrated under reduced pressure. The residue was purified by reverse-phase flash chromatography (chromatographic conditions: column: spherical C18, 20-40 μm, 120 g; mobile phase A: pure water containing 0.1% formic acid; mobile phase B: acetonitrile; flow rate: 85 mL / min; gradient: 5%B to 95%B within 30 minutes; detector: 254 nm). When the content of mobile phase B reached 45%, the product fraction was collected and concentrated under reduced pressure to obtain (4-(dimethylphosphoryl)-2,3-dihydrobenzofuran-7-yl)carbamate tert-butyl (110 mg, 0.35 mmol, yield: 11.3%). LCMS m / z: 312 [M+H] + .

[0162] 4) Synthesis of (4-(dimethylphosphoryl)-2,3-dihydrobenzofuran-7-yl)(propa-2-in-1-yl)carbamate tert-butyl [ka]

[0163] Under room temperature conditions, tert-butyl (4-(dimethylphosphoryl)-2,3-dihydrobenzofuran-7-yl)carbamate (70 mg, 0.23 mmol) was dissolved in N,N-dimethylformamide (5 mL) solution, to which 3-bromopropa-1-yne (137 mg, 1.15 mmol) and cesium carbonate (375 mg, 1.15 mmol) were added. The resulting reaction mixture was heated to 80°C under nitrogen protection and stirred for 3 hours. Water (50 mL) was added to the reaction mixture to quench it, and it was extracted with ethyl acetate (20 mL x 3). The combined organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane / methanol = 20 / 1) to obtain (4-(dimethylphosphoryl)-2,3-dihydrobenzofuran-7-yl)(propa-2-in-1-yl)carbamate tert-butyl (30 mg, 0.086 mmol, yield: 38.1%). LCMS m / z: 350 [M+...

Claims

1. The compound represented by formula (I), its pharmaceutically acceptable salts, solvates, enantiomers, or isotopic substitutions. 【Chemistry 195】 (In the formula, Ring B may represent a cyclic structure of any 3 to 20 members, and may be a monocyclic, dicyclic, or tricyclic structure. The cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring. Z ３ is absent, a single bond, -C(R ｄ１ )(R ｄ２ )-, -C(=R ｄ１ )-, -(R ｄ１ )(P=O)-, =C(R ｄ１ )-, NH, -C(R ｄ１ )(R ｄ２ )(R ｄ１ )(R ｄ２ )-, -C(R ｄ１ )=C(R ｄ１ )-, -C(R ｄ１ )(R ｄ２ )(R ｄ１ )=C(R ｄ１ )-, 【Chemistry 196】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z ３ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, X １ , X ２ It is selected independently of N or CR, Each R １ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ Selected from -COOH, amide group, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group, or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected from R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ substituted with one or more substituents selected from heterocyclic groups, or any two adjacent Rs １ together with the atoms to which they are attached form a 5- to 30-membered heteroaryl group, a 5- to 30-membered saturated or partially saturated cycloalkyl group, or a 5- to 30-membered saturated or partially saturated heterocyclic group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, heterocyclic group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ alkoxy group, -NH ２ , -NHC １－６ alkyl, -N(C １－６ alkyl) ２ , =O, and optionally substituted with a group selected from saturated or partially saturated C ３－６ cycloalkyl group, and the C １－６ alkyl group and C １－６ alkoxy group are optionally substituted with one or more groups selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ , OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ cycloalkyl group, and the hydrogen on R １ is optionally, preferably, substituted with one or more groups selected from hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ , OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ cycloalkyl group, Each R ２ may be the same or different and are each independently hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxy group, mercapto group, C １－１０ alkyl group, C ２－１０ alkenyl group, C ２－１０ alkynyl group, C １－１０ alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N - di(C １－１０ alkyl)amino, C １－１０ alkoxy group, C １－１０ alkylacyl group, C １－１０ alkoxy group, C １－１０ alkylsulfonyl group, C １－１０ alkylsulfinyl group, C ３－１０ cycloalkylamino group, C ３－１０ heterocycloalkylamino group, C ３－１０ cycloalkoxy group, C ３－１０ heterocycloalkoxy group, C A ３－１０ cycloalkylacyl group, C ３－１０ cycloalkoxyacetyl group, C ３－１０ cycloalkylsulfonyl group and C ３－１０ cycloalkylsulfinyl group, -Y-Q or M group, or optionally two Rs ２ together with the atom to which they are attached may form a 5- to 6-membered aryl or heteroaryl group, a 3- to 8-membered saturated or partially saturated cycloalkyl group, or a 3- to 8-membered saturated or partially saturated heterocyclyl group, and the alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, heterocyclyl group are optionally substituted with one or more groups selected from hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ , OH, OCH ３ ]>、OCH ２ CH ３ and the hydrogen on R ２ is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemistry 197】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 198】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Y is arbitrarily and independently selected from O, S, or NR. Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, 4, and 5. However, ring B 【Chemistry 199】 In this case, any two R and / or R1 are linked together, forming a 7-30 member macrocyclic or fused ring structure with the atoms on the ring.

2. The compound according to claim 1, characterized by having the structure of formula (IA), a pharmaceutically acceptable salt, solvate, enantiomer, or isotope-substituted product thereof. 【Chemistry 200】 (In the formula, Y, Y １ , Y ２ , Y ３ , Y ４ , Y ５ These are, independently, non-existent, single bond, and -C(R). ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, N, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical Engineering 201】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ Selected from saturated or partially saturated heteroaryl groups, and Y, Y １ , Y ２ , Y ３ , Y ４ , Y ５ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Ring B may represent a cyclic structure of any 3 to 20 members, and may be a monocyclic, dicyclic, or tricyclic structure. The cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring. Z ３ is non-existent, single bond, -C(R) ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, NH, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical Engineering 202】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z ３ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, X １ It is selected independently of N or CR, Each R １ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ Selected from -COOH, amide group, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group, or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected from R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemical 203】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical 204】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, 4, and 5.

3. A compound according to claim 1 or 2, characterized by having the structure of formula (IB), a pharmaceutically acceptable salt, solvate, enantiomer or isotope-substituted product thereof. 【Chemical 205】 (In the formula, Y, Y １ , Y ２ , Y ３ , Y ４ , Y ５ Each of these is independently -C(R ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, NH, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical 206】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ Selected from saturated or partially saturated heteroaryl groups, and Y, Y １ , Y ２ , Y ３ , Y ４ , Y ５ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Z ３ is non-existent, single bond, -C(R) ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, NH, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical 207】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z ３ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, X is O, S, N(R ｄ４ ), -C(R ｄ１ ) (Caution ｄ２ )-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ -, or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ A saturated or partially saturated aryl group, or -C(R ｄ１ ) = C(R ｄ１ ) - Selected independently of, X1 is selected independently of N or CR. Each R １ These may be the same or different, and may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH independently of each other. ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group substituted with an alkyl group, or a carboxyl group equivalent, or an M group, selected from R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemical 208】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical Engineering 209】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ may be linked together to form a 3- to 30-membered cyclic structure, the cyclic structure may be a monocyclic, bicyclic, bridged ring or spiro ring structure, and may optionally contain 0 or more heteroatoms or unsaturated bonds, and further R ａ The hydrogen above is hydrogen, deuterium, halogen, pentafluorothio group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ alkoxy group, -NH ２ , -NHC １－６ alkyl, -N(C １－６ alkyl) ２ , oxy group, haloalkyl group, deuterated alkyl group and saturated or partially saturated C ３－６ cycloalkyl group or heterocycloalkyl group, optionally substituted with one or more selected from, R ｄ１ 、R ｄ２ 、R ｄ３ 、R ｄ４ 、R ｄ５ 、R ｄ６ 、R ｄ７ Each of R ２ 、R １－１０ 、R ２－１０ 、R １－１０ 、R １－１０ 、R １－１０ 、R ２－１０ 、R ３－１０ 、R ３－１０ ​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​ ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, and 4.

4. A compound according to any one of claims 1 to 3, characterized by having the structure of formula (IC), a pharmaceutically acceptable salt thereof, a solvate, an enantiomer, or an isotope-substituted compound thereof. 【Chemical 210】 (In the formula, Y, Y １ , Y ２ , Y ３ , Y ４ , Y ５ is, independently of each other, -C(R ｄ１ )(R ｄ２ )-, -C(=R ｄ１ )-, -(R ｄ１ )P(=O)-, =C(R ｄ１ )-, NH, -C(R ｄ１ )(R ｄ２ )(R ｄ１ )(R ｄ２ )-, -C(R ｄ１ )=C(R ｄ１ )-, -C(R ｄ１ )(R ｄ２ )(R ｄ１ )=C(R ｄ１ )-, 【Chemistry 211】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl, C ３－１０ Saturated or partially saturated heterocycloalkyl, C ４－１０ Saturated or partially saturated aryl, C ４－１０ Selected from saturated or partially saturated heteroaryls, and Y, Y １ , Y ２ , Y ３ , Y ４ , Y ５ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Z ３ is non-existent, single bond, -C(R) ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, NH, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ ) -, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical Engineering 212】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z ３ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, X is selected independently of N or -CR-, X １ It is selected independently of N or CR, Each R １ These may be the same or different, and may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH independently of each other. ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group substituted with an alkyl group, or a carboxyl group equivalent, or an M group, selected from R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemistry 213】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical 214】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, and 4.

5. A compound according to any one of claims 1 to 4, characterized by having a formula (ID) structure, a pharmaceutically acceptable salt thereof, a solvate, an enantiomer, or an isotope-substituted compound thereof. 【Chemical 215】 (In the formula, Y １ , Y ２ , Y ３ , Y ４ , Y ５ Each of these independently corresponds to -C(R ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, NH, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical 216】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ Selected from saturated or partially saturated heteroaryl groups, and Y １ , Y ２ , Y ３ , Y ４ , Y ５ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ Alkyl, C １－３ Arbitrarily selected from alkoxys, X is selected independently of N or -CR-, X １ It is selected independently of N or CR, Each R １ These may be the same or different, and may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH independently of each other. ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group substituted with an alkyl group, or a carboxyl group equivalent, or an M group, selected from R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemical 217】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical 218】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ Alkyl, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned heterozygotes are O, N, S, P, -P=O, S=O, or SO ２ Represents a heteroatom or group and its isotope, which are arbitrarily and independently selected from, The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, and 4.

6. A compound according to any one of claims 1 to 5, characterized by having the structure of formula (IE), a pharmaceutically acceptable salt thereof, a solvate, an enantiomer, or an isotope-substituted compound thereof. 【Chemical 219】 (In the formula, Y １ , Y ２ , Y ３ , Y ４ , Y ５ Each of these independently corresponds to -C(R ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, NH, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical 220】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ Selected from saturated or partially saturated heteroaryl groups, and Y １ , Y ２ , Y ３ , Y ４ , Y ５ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ Alkyl, C １－３ Arbitrarily selected from alkoxys, X is selected independently of N or -CR-, X １ It is selected independently of N or CR, Each R １ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, amide group, sulfamoylamino group, methanesulfonamide group, or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected from R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemistry 221】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 222】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned heterozygotes are O, N, S, P, -P=O, S=O, or SO ２ Represents a heteroatom or group and its isotope, which are arbitrarily and independently selected from, The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, and 4.

7. A compound according to any one of claims 1 to 6, characterized by having a formula (IF) structure, a pharmaceutically acceptable salt thereof, a solvate, an enantiomer, or an isotope-substituted compound thereof. 【Chemistry 223】 (In the formula, Y, Y １ , Y ２ , Y ３ , Y ４ , Y ５ Each of these independently corresponds to -C(R ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, NH, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 224】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ Selected from saturated or partially saturated heteroaryl groups, and Y １ , Y ２ , Y ３ , Y ４ , Y ５ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ Alkyl, C １－３ Arbitrarily selected from alkoxys, Ring C may optionally represent a 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may optionally be hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, X is selected independently of N or -CR-, X １ It is selected independently of N or CR, Each R １ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or selected from an M group, and R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemical 225】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 226】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ Alkyl, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned heterozygotes are O, N, S, P, -P=O, S=O, or SO ２ Represents a heteroatom or group and its isotope, which are arbitrarily and independently selected from, The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, and 4.

8. A compound according to any one of claims 1 to 7, characterized by having a (IG) structure, a pharmaceutically acceptable salt thereof, a solvate, an enantiomer, or an isotope-substituted compound thereof. 【Chemistry 227】 (In the formula, Y, Y １ , Y ２ , Y ３ , Y ４ , Y ５ Each of these independently corresponds to -C(R ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, NH, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 228】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ Selected from saturated or partially saturated heteroaryl groups, and Y １ , Y ２ , Y ３ , Y ４ , Y ５ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ Alkyl, C １－３ Arbitrarily selected from alkoxys, Ring C may optionally represent a 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may optionally be hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, X １ It is selected independently of N or CR, Each R １ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or selected from an M group, and R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemistry 229】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 230】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned heterozygotes are O, N, S, P, -P=O, S=O, or SO ２ Represents a heteroatom or group and its isotope, which are arbitrarily and independently selected from, The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, and 4.

9. It has a formula (IH) structure, 【Chemistry 231】 (In the formula, Yは、-C(R ｄ１ )(R ｄ２ )-、-C(=R ｄ１ )-、-(R ｄ１ )P(=O)-、=C(R ｄ１ )-、NH、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )(R ｄ２ )-、-C(R ｄ１ )=C(R ｄ１ )-、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )=C(R ｄ１ )-、 【Chemistry 232】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Y is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, X is selected independently of N or -CR-, X １ It is selected independently of N or CR, Each R １ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or selected from an M group, and R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemical 233】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 234】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and at least one R ｄ１ and R ｄ２ These are linked together, forming a 3-20 membered cyclic structure with the atoms to which they are bonded. The aforementioned heterozygotes are O, N, S, P, -P=O, S=O, or SO ２ Represents a heteroatom or group and its isotope, which are arbitrarily and independently selected from, The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, and 4. Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer, or isotope-substituted compound has the structure of formula (II), 【Chemical 235】 (In the formula, Yは、-C(R ｄ１ )(R ｄ２ )-、-C(=R ｄ１ )-、-(R ｄ１ )P(=O)-、=C(R ｄ１ )-、NH、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )(R ｄ２ )-、-C(R ｄ１ )=C(R ｄ１ )-、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )=C(R ｄ１ )-、 【Chemistry 236】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Y is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, X １ It is selected independently of N or CR, Each R １ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or selected from an M group, and R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemistry 237】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical 238】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and at least one R ｄ１ and R ｄ２ These are linked together, forming a 3-20 membered cyclic structure with the atoms to which they are bonded. The aforementioned heterozygotes are O, N, S, P, -P=O, S=O, or SO ２ Represents a heteroatom or group and its isotope, which are arbitrarily and independently selected from, The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, and 4. Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer, or isotope-substituted compound has the structure of formula (IJ). 【Chemistry 239】 (In the formula, 【Chemistry 240】 represents either a single bond or a double bond, Z ３ is non-existent, single bond, -C(R) ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, NH, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 241】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ -, or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z ３ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, X １ , X ２ It is selected independently of N or CR, Yは、-C(R ｄ１ )(R ｄ２ )-、-C(=R ｄ１ )-、-(R ｄ１ )P(=O)-、=C(R ｄ１ )-、NH、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )(R ｄ２ )-、-C(R ｄ１ )=C(R ｄ１ )-、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )=C(R ｄ１ )-、 【Chemistry 242】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - Selected independently of, Each R １ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or selected from an M group, and R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, acyl group, carboxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C3-10 heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, heterocycloalkyl groups, -Y-Q groups, or M groups, M is 【Chemistry 243】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 244】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Y is arbitrarily and independently selected from O, S, or NR. Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. The compound according to any one of claims 1 to 8, characterized in that m is an integer arbitrarily selected from 0, 1, 2, 3, or 4, and a pharmaceutically acceptable salt, solvate, enantiomer, or isotope-substituted product thereof.

10. It has an IK structure, 【Chemistry 245】 (In the formula, 【Chemistry 246】 represents either a single bond or a double bond, Z ３ is non-existent, single bond, -C(R) ｄ１ ) (Caution ｄ２ )-,-C(=R ｄ１ ) -, -(R ｄ１ )P(=O)-,=C(R ｄ１ )-, NH, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 247】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ -, or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z ３ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, X １ , X ２ It is selected independently of N or CR, Yは、-C(R ｄ１ )(R ｄ２ )-、-C(=R ｄ１ )-、-(R ｄ１ )P(=O)-、=C(R ｄ１ )-、NH、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )(R ｄ２ )-、-C(R ｄ１ )=C(R ｄ１ )-、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )=C(R ｄ１ )-、 【Chemistry 248】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - Selected independently of, Each R １ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or selected from an M group, and R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, acyl group, carboxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C3-10 heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, heterocycloalkyl groups, -Y-Q groups, or M groups, M is 【Chemistry 249】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - [Chemical 250] , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Y is arbitrarily and independently selected from O, S, or NR. Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer, or isotope-substituted compound has the structure of formula (IL), 【Chemistry 251】 (In the formula, X １ It is selected independently of N or CR, Each R １ These may be the same or different, and each may independently be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH, and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group, or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or an M group, selected from R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, heterocycloalkyl groups, -Y-Q groups, or M groups, M is 【Chemistry 252】 Selected arbitrarily and independently from, Z does not exist, C(R ｄ１ ) (Caution ｄ２ ), O, NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 253】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and Z １ Z ２ The hydrogen atoms above are further optionally substituted with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, Y is arbitrarily and independently selected from O, S, or NR. Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned hetero represents a heteroatom or group and its isotope, which is arbitrarily and independently selected from O, N, S, P, -P=O, S=O, or SO2. The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, 3, and 4. n is an integer arbitrarily selected from 0, 1, 2, 3, 4, and 5. Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer, or isotope-substituted compound has the structure of formula (IM). 【Chemistry 254】 (In the formula, Y ３ and Y ４ is -C(R ｄ１ ) (Caution ｄ２ )-, O, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ ) - or -C (=O) - are independently selected, Each R １ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or selected from an M group, and R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemistry 255】 Selected arbitrarily and independently from, Z is non-existent, C(R) ｄ１ ) (Caution ｄ２ ), NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 256】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z is further optionally substituted, preferably, with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Selectively chosen from alkoxy groups, Yは、-C(R ｄ１ )(R ｄ２ )-、-C(=R ｄ１ )-、-(R ｄ１ )P(=O)-、=C(R ｄ１ )-、NH、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )(R ｄ２ )-、-C(R ｄ１ )=C(R ｄ１ )-、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )=C(R ｄ１ )-、 【Chemistry 257】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ Selected independently from saturated or partially saturated heteroaryl groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned heterozygotes are O, N, S, P, -P=O, S=O, or SO ２ Represents a heteroatom or group and its isotope, which are arbitrarily and independently selected from, The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, and 3. The compound according to any one of claims 1 to 9, characterized in that n is an integer arbitrarily selected from 0, 1, 2, 3, or 4, and a pharmaceutically acceptable salt, solvate, enantiomer, or isotope-substituted product thereof.

11. It has the formula (IN) structure, 【Chemistry 258】 (In the formula, Y ３ and Y ４ is -C(R ｄ１ ) (Caution ｄ２ )-, O, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ ) - or -C (=O) - are independently selected, Each R １ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or selected from an M group, and R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemistry 259】 Selected arbitrarily and independently from, Z is non-existent, C(R) ｄ１ ) (Caution ｄ２ ), NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical 260】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z is further optionally substituted, preferably, with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Selectively chosen from alkoxy groups, Yは、-C(R ｄ１ )(R ｄ２ )-、-C(=R ｄ１ )-、-(R ｄ１ )P(=O)-、=C(R ｄ１ )-、NH、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )(R ｄ２ )-、-C(R ｄ１ )=C(R ｄ１ )-、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )=C(R ｄ１ )-、 【Chemistry 261】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ Selected independently from saturated or partially saturated heteroaryl groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ Alkyl, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned heterozygotes are O, N, S, P, -P=O, S=O, or SO ２ Represents a heteroatom or group and its isotope, which are arbitrarily and independently selected from, The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, and 3. n is an integer arbitrarily selected from 0, 1, 2, 3, and 4. Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer, or isotope-substituted compound has the structure of formula (IO), 【Chemistry 262】 (In the formula, Y ３ and Y ４ is -C(R ｄ１ ) (Caution ｄ２ )-, O, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ ) - or -C (=O) - are independently selected, Each R １ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or selected from an M group, and R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemical 263】 Selected arbitrarily and independently from, Z is non-existent, C(R) ｄ１ ) (Caution ｄ２ ), NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemistry 264】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z is further optionally substituted, preferably, with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Selectively chosen from alkoxy groups, Yは、-C(R ｄ１ )(R ｄ２ )-、-C(=R ｄ１ )-、-(R ｄ１ )P(=O)-、=C(R ｄ１ )-、NH、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )(R ｄ２ )-、-C(R ｄ１ )=C(R ｄ１ )-、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )=C(R ｄ１ )-、 【Chemical 265】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ Selected independently from saturated or partially saturated heteroaryl groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent is selected from alkyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, the substituents being hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned heterozygotes are O, N, S, P, -P=O, S=O, or SO ２ Represents a heteroatom or group and its isotope, which are arbitrarily and independently selected from, The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, and 3. n is an integer arbitrarily selected from 0, 1, 2, 3, and 4. Preferably, the compound, its pharmaceutically acceptable salt, solvate, enantiomer, or isotope-substituted compound has the structure of formula (IP). 【Chemical 266】 (In the formula, Y ３ and Y ４ is -C(R ｄ１ ) (Caution ｄ２ )-, O, -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ ) - or -C (=O) - are independently selected, Each R １ They may be the same or different, and independently of each other, they may be hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, -SH and -NH ２ , selected from -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, amide group, aminoacyl group, aminosulfonyl group, sulfamoylamino group, methanesulfonamide group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent substituted with an alkyl group, or selected from an M group, and R １ The hydrogen atoms above can be optionally, preferably, H, deuterium, halogen, pentafluorosulfanyl group, or OCH ３ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Substituted with one or more substituents selected from heterocyclyl groups, or any two adjacent R groups １ These, together with the atoms to which they are bonded, form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, or a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogen on the aryl group, heteroaryl group, saturated or partially saturated cycloalkyl group, or heterocyclyl group is hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a group selected from cycloalkyl groups, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, and R １ The hydrogens above are optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R ２ These may be the same or different, and may be independent of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, amino group, hydroxyl group, mercapto group, C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group, C １－１０ Alkylamino group, dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, N,N-di(C) １－１０ Alkyl)amino, C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkoxy group, C １－１０ Alkyl sulfonyl group, C １－１０ Alkyl sulfinyl group, C ３－１０ Cycloalkylamino group, C ３－１０ Heterocycloalkylamino group, C ３－１０ Cycloalkoxy group, C ３－１０ Heterocycloalkoxy group, C ３－１０ Cycloalkylacyl group, C ３－１０ Cycloalkoxyacetyl group, C ３－１０ Cycloalkylsulfonyl group and C ３－１０ Selected from a cycloalkylsulfinyl group, -Y-Q or M group, or optionally two R groups ２ These may, together with the atoms to which they are bonded, form a 5-6 membered aryl group or heteroaryl group, a 3-8 membered saturated or partially saturated cycloalkyl group, or a 3-8 membered saturated or partially saturated heterocyclyl group. The alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, cycloalkyl group, and heterocyclyl group may be hydrogen, deuterium, alkyl group, halogen, pentafluorosulfanyl group, oxo, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ Optionally substituted with one or more groups selected from and R ２ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, M is 【Chemistry 267】 Selected arbitrarily and independently from, Z is non-existent, C(R) ｄ１ ) (Caution ｄ２ ), NR ｄ１ , -C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) = C(R ｄ１ )-,-C(R ｄ１ ) (Caution ｄ２ ) C (R ｄ１ ) = C(R ｄ１ ) - 【Chemical 268】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-,-N(R ｄ７ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ A heteroaryl group is independently selected from saturated or partially saturated heteroaryl groups, and the hydrogen on Z is further optionally substituted, preferably, with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ alkyl group, C １－３ Selectively chosen from alkoxy groups, Yは、-C(R ｄ１ )(R ｄ２ )-、-C(=R ｄ１ )-、-(R ｄ１ )P(=O)-、=C(R ｄ１ )-、NH、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )(R ｄ２ )-、-C(R ｄ１ )=C(R ｄ１ )-、-C(R ｄ１ )(R ｄ２ )C(R ｄ１ )=C(R ｄ１ )-、 【Chemistry 269】 , -OC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )O-,-NHC(R ｄ１ ) (Caution ｄ２ )-,-C(R ｄ１ ) (Caution ｄ２ )NH-, -C(=O)N(R ｄ３ )-,-N(R ｄ４ )-,-C(=NR ｄ５ ) -, -S (=O) ２ N(R) ｄ６ )-, -O-, -S-, -C(=O)O-, -OC(=O)-, -C(=O)-, -C(=S)-, -S(=O)-, -S(=O) ２ - or C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ４－１０ Saturated or partially saturated aryl group, C ４－１０ Selected independently from saturated or partially saturated heteroaryl groups, Q represents an arbitrary 3- to 20-membered cyclic structure, which may be a monocyclic, dicyclic, or tricyclic structure, and the cyclic structure may be an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, bridging ring, or spirocyclic ring, or a fused ring structure combining an aromatic ring, heteroaromatic ring, aliphatic ring, heterocyclic ring, or bridging ring, and the hydrogen on ring Q may be optionally, preferably, hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, alkyl group, alkenyl group, alkynyl group, CN, CF ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Substituted with one or more groups selected from cycloalkyl groups, Each R may be the same or different, and may be independently of each other hydrogen, deuterium, -CN, haloalkyl group, haloalkoxy group, deuterated alkyl group, deuterated alkoxy group, -OH, -SH and -NH ２ , selected from dialkylphosphonyl group, alkylsulfonyl group, sulfonyl group, alkylsulfinyl group, sulfamoyl group, sulfamoylamino group, methanesulfonamide group or -COOH, or C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C ２－１０ Heteroalkyl groups, C ３－１０ Saturated or partially saturated cycloalkyl groups, C ３－１０ Saturated or partially saturated heterocycloalkyl groups, C ３－１０ Cycloalkyl groups or C ３－１０ C substituted with heterocycloalkyl groups １－１０ alkyl group, C ３－１０ C substituted with a cycloalkyl group ２－１０ Heteroalkyl groups, C ３－１０ Heterocyclyl group, C １－１０ A carboxyl group or carboxyl group equivalent selected from alkyl-substituted carboxyl groups, and the hydrogen on R is further optionally substituted, preferably with one or more substituents, wherein the substituents are hydrogen, deuterium, halogen, pentafluorosulfanyl group, alkyl group, haloalkyl group, cyano group, cyanoethyl group, O=, OH, C １－３ Alkyl, C １－３ Arbitrarily selected from alkoxy groups, R ａ and R ｂ The elements are, optionally and independently, hydrogen, deuterium, halogen, pentafluorosulfanyl group, and NH ２ , C １－１０ alkyl group, C ２－１０ Alkenyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or R ａ and R ｂ Or R ａ and R ２ Or R ａ and R １ These may be linked together to form a 3- to 30-membered cyclic structure, and the cyclic structure may be a monocyclic, dicyclic, bridging, or spirocyclic structure, and may optionally contain zero or more heteroatoms or unsaturated bonds, and further R ａ The hydrogens above are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , oxy groups, haloalkyl groups, deuterated alkyl groups and saturated or partially saturated C ３－６ Optionally substituted with one or more cycloalkyl groups or heterocycloalkyl groups, R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ Each of these may be the same or different, and may be any and all independently of each other: hydrogen, deuterium, halogen, pentafluorosulfanyl group, NH ２ , C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Selected from heterocyclyl groups, the C １－１０ alkyl group, C ２－１０ Alkynyl group or C １－１０ Alkoxy group, C １－１０ Alkylacyl group, C １－１０ Alkyl sulfonyl group, C ２－１０ Heteroalkyl groups, C ３－１０ Cycloalkyl groups, C ３－１０ Heterocycloalkyl groups, C ３－１０ C substituted with a cyclic hydrocarbon group １－１０ Alkyl or C ３－１０ Cycloalkyl groups, C ３－１０ C substituted with heterocycloalkyl groups ３－１０ Heterocyclyl groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, OH, and C ３－１０ Optionally substituted with one or more substituents selected from saturated or partially substituted saturated cycloalkyl or heterocyclyl groups, or any R ｄ１ , R ｄ２ , R ｄ３ , R ｄ４ , R ｄ５ , R ｄ６ , R ｄ７ are mutual, or / and R １ Or R ２ Together with the atoms to which they are bonded, they form a 5-30 membered heteroaryl group, a 5-30 membered saturated or partially saturated cycloalkyl group, and a 5-30 membered saturated or partially saturated heterocyclyl group, and the hydrogens on the heteroaryl group, saturated or partially saturated cycloalkyl group, and heterocycloalkyl group are hydrogen, deuterium, halogen, pentafluorosulfanyl group, -CN, -OH, CF ３ , C １－６ alkyl group, C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl, -N(C) １－６ Alkyl) ２ , = O, and saturated or partially saturated C ３－６ Optionally substituted with a cycloalkyl group, and C １－６ Alkyl and C １－６ Alkoxy groups include hydrogen, deuterium, halogen, pentafluorosulfanyl group, oxo, CN, and CF. ３ OH, OCH ３ , OCH ２ CH ３ , saturated or partially saturated C ３－６ Optionally substituted with one or more groups selected from cycloalkyl groups, The aforementioned heterozygotes are O, N, S, P, -P=O, S=O, or SO ２ Represents a heteroatom or group and its isotope, which are arbitrarily and independently selected from, The halogen is arbitrarily and independently selected from F, Cl, Br, I and their isotopes. m is an integer arbitrarily selected from 0, 1, 2, and 3. The compound according to any one of claims 1 to 10, characterized in that n is an integer arbitrarily selected from 0, 1, 2, 3, or 4, and a pharmaceutically acceptable salt, solvate, enantiomer, or isotope-substituted product thereof.

12. A compound according to any one of claims 1 to 11, characterized by having the structure of formula (III), a pharmaceutically acceptable salt thereof, a solvate, an enantiomer, or an isotope-substituted compound thereof. 【Chemistry 270】 (In the formula, X is selected from N or CR, and R is H or C １－６ Alkyl, halo C １－６ Selected from alkyl groups, E is O, S, NR ｅ Selected from, R ｅ H, C １－６ alkyl group, C ３－６ Cycloalkyl groups, Halo C １－６ Selected from alkyl groups, Each R １ H, C are identical or different, and independent of each other. １－６ alkyl group, C １－６ Alkoxy group, S(O) ２ C １－６ Alkyl, P(O)(C １－６ Alkyl) ２ Selected from, Each R ２ These are identical or different, and independently of each other, H, P(O)(C １－６ Alkyl) ２ Selected from -NH-Q, where Q is unsubstituted or optionally one, two or more R ｑ Selected from 5-6 member heterocyclyl groups substituted with each R ｑ These are the same or different, and each is independently H, halogen, and C. １－６ Alkyl, halo C １－６ Selected from alkyl groups, R ｄ１ , R ｄ２ H and C are identical or different, and are independent of each other. １－６ alkyl group, C １－６ Selected from alkoxy groups, R ｙ１ , R ｙ２ H and C are identical or different, and are independent of each other. １－６ alkyl group, C １－６ Selected from alkoxy groups, or R ｙ１ , R ｙ２ These, together with the atoms to which they are linked, form a 5-12 membered heterocyclyl group or a 5-10 membered heteroaryl group. m is selected from 0, 1, 2, or 3. n is selected from 0, 1, 2, 3, or 4. Preferably, R is H, C １－３ Alkyl, halo C １－３ Selected from alkyl groups, Preferably, R is H, CH ２ CF ３ Selected from, Preferably, R ｅ H, C ３－６ Cycloalkyl groups, Halo C １－３ Selected from alkyl groups, Preferably, R ｅ The cyclopropyl group is CH ２ CF ３ Selected from, Preferably, 【Chemistry 271】 Selected from, Preferably, each R １ H, S(O) are identical or different, and independent of each other. ２ C １－３ Alkyl, P(O)(C １－３ Alkyl) ２ Selected from, Preferably, each R １ H, S(O) are identical or different, and independent of each other. ２ CH ３ , P(O)(CH ３ ) ２ Selected from, Preferably, each R ２ These are identical or different, and independently of each other, H, P(O)(C １－３ Alkyl) ２ Selected from -NH-Q, for example H, P(O)(C １－３ Alkyl) ２ , 【Chemistry 272】 ) and Preferably, Q is unsubstituted, or optionally one, two or more R ｑ A six-membered heterocyclyl group substituted with, for example, piperidinyl, is selected. Preferably, each R ｑ These are the same or different, and independently of each other, H, halogen, and C. １－６ Alkyl groups, for example, selected from H, F, and methyl, Preferably, each R ２ These are identical or different, and independently of each other, H, P(O)(CH ３ ) ２ , 【Chemistry 273】 ) are selected from, Preferably, R ｙ１ , R ｙ２ H, C are identical or different, and independent of each other. １－３ Selected from alkoxy groups, such as H and methoxy groups, Preferably, R ｙ１ , R ｙ２ These, along with the atoms to which they are linked, are 5-7 membered heterocyclyl groups, 12-membered heterocyclyl groups, or 5-6 membered heteroaryl groups, such as furan rings and dihydrofuran rings. 【Chemistry 274】 Forming, Preferably, 【Chemistry 275】 Selected from, Preferably, 【Chemistry 276】 (Selected from)

13. The compound according to any one of claims 1 to 12, characterized in that the compound is selected from novel compounds having structures disclosed herein, a pharmaceutically acceptable salt, solvate, enantiomer or isotope-substituted product thereof.

14. A pharmaceutical composition comprising a therapeutically effective amount of the compound described in any one of claims 1 to 13, or at least one of its pharmaceutically acceptable salts, solvates, enantiomers, or isotopic substitutions.

15. Use of a compound according to any one of claims 1 to 13, a pharmaceutically acceptable salt thereof, solvate, enantiomer or isotope-substituted thereof, or a pharmaceutical composition according to claim 14, in the preparation of a drug for preventing and / or treating related diseases caused by abnormalities in the P53 signaling pathway.

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