Cosmetic nail polish formulations

Abstract

Various medical and lifestyle-related factors can cause discoloration, thickening, brittleness, and dryness of the toenails and / or fingernails. Examples of such factors include onychomycosis, psoriasis, sports injuries, and the use of nail polish. This invention relates to topical cosmetic nail formulations, the use of said formulations on nails, and cosmetic methods for improving the appearance of nails.

Description

Technical Field

[0001] The present invention relates to a topical cosmetic nail formulation (formulation or prescription), the use of the formulation on nails, and a cosmetic method for improving the appearance of nails.

Background Art

[0002] Due to various medical and lifestyle-related factors, the toenails and / or fingernails may become discolored, thickened, brittle, and dry. Examples of such factors include onychomycosis (or nail fungus), psoriasis, sports injuries, and the use of nail varnish (or nail paint).

Summary of the Invention

[0003] The present invention solves this problem by providing a nail formulation (or nail formulation) that conditions the nails, aids in nail recovery, and restores the appearance of the nails.

[0004] In a first aspect of the present invention, there is provided a topical aqueous cosmetic nail formulation comprising: a) an acyclic polymer or a mixture of polymers, wherein each acyclic polymer in the acyclic polymer or the mixture contains 3 to b) polyethylene glycol (PEG) 500 to PEG 8000 A nail formulation is provided.

[0005] In a further aspect of the present invention, there is provided the use of the formulation according to the first aspect on nails.

[0006] In a further aspect of the present invention, there is provided a cosmetic method for improving the appearance of nails, the method comprising applying the formulation according to the first aspect to the nails and / or the skin around the nails.

Brief Description of the Drawings

[0007] [Figure 1] Figure 1 shows the rate of change over time (percentage: %) in the mass of toenail fragments compared with Tinexyl® compared with a comparative product. (Tinexyl®: 50% polyethylene glycol 4000, 44.9% water, 5% lactic acid, 0.05% polymer-TXYL30 (30mer polyarginine (poly(L-arginine HCl)) MW=5800, 0.05% polymer-TXYL50 (50mer polyarginine (poly(L-arginine HCl)) MW=9600) [Figure 2a] Figure 2a shows the percentage change over time (%) in the mass of toenail fragments when a formulation of 50% PEG4000 containing 0.05% PLR-30, 0.05% PLR-50, and 5% lactic acid is compared to water. [Figure 2b] Figure 2b shows the data presented in Figure 2a, illustrating how the weight increase in mg corresponds to the percentage increase in the total weight of the nail fragment over time. The weight increase in mg correlates with the amount of product applied and the amount that penetrates the nail. [Figure 3] Figure 3 shows the rate of change (percentage: %) over time in the mass of toenail fragments using the immersion method, comparing Tinexyl® with a comparative product. [Figure 4] Figure 4 shows the rate of change (percentage: %) in the mass of toenail fragments over time. The increase in weight of the nail fragments over time indicates that Tinexyl® penetrated the nails and provided moisture. [Figure 5] Figure 5 shows the efficacy of the ingredients contained in the product. This is represented by the average number of microbial cells at a given time point. [Figure 6] Figure 6 shows excised toenails immersed in Tinexyl® for up to 12 weeks. This figure shows improvement in the appearance of the excised toenails. [Figure 7] Figure 7 shows excised toenails immersed in Tinexyl® for up to 28 days. This figure shows the improvement in the appearance of the excised toenails. [Figure 8]Figure 8 shows the rate of change over time in the mass of human toenail fragments when excised toenails are immersed in Tinexyl®. [Figure 9] Figure 9 shows Subject 1 at day 0, week 2, and week 3 after using Tinexyl®. [Figure 10] Figure 10 shows Subject 1 on day 0 and week 7 after using Tinexyl®. [Figure 11] Figure 11 shows Subject 2 at day 0, week 5, week 6, and week 9 after using Tinexyl®. [Figure 12] Figure 12 shows Subject 3 at day 0, week 2, week 5, and week 9 after using Tinexyl®. [Figure 13] Figure 13 shows Subject 3 at day 0 and week 12 after using Tinexyl®. [Figure 14] Figure 14 shows Subject 4 at day 0 and week 6 after using Tinexyl®. [Figure 15] Figure 15 shows Subject 5 at day 0 and week 8 after using Tinexyl®. [Figure 16] Figure 16 shows Subject 6 at day 0 and week 8 after using Tinexyl®. [Figure 17] Figure 17 shows Subject 7 at day 0 and week 10 after using Tinexyl®. [Figure 18] Figure 18 shows Subject 8 at day 0 and week 8 after using Tinexyl®. [Figure 19] Figure 19 shows Subject 9 at day 0 and week 5 after using Tinexyl®. [Figure 20] Figure 20 shows an example of a polymer in the formulation. [Figure 21] Figure 21 shows the left foot of subject 10 on day 0 and day 28 after using Tinexyl®. [Figure 22] Figure 22 shows the right foot of subject 10 on day 0 and day 28 after using Tinexyl®. [Figure 23] Figure 23 shows the left foot of Subject 11 at Day 0, Day 21, 6 weeks, and 9 weeks after the use of Tinexyl®. [Figure 24] Figure 24 shows the right foot of Subject 11 at Day 0, Day 21, 6 weeks, and 9 weeks after the use of Tinexyl®. [Figure 25] Figure 25 shows the left foot of Subject 12 at Day 0, 5 weeks, 7 weeks, and 9 weeks after the use of Tinexyl®. [Figure 26] Figure 26 shows the left foot of Subject 12 at 15 weeks, 18 weeks, and 21 weeks after the use of Tinexyl®. [Figure 27] Figure 27 shows the right foot of Subject 12 at Day 0, 5 weeks, 7 weeks, and 9 weeks after the use of Tinexyl®. [Figure 28] Figure 28 shows the right foot of Subject 12 at 15 weeks, 18 weeks, and 21 weeks after the use of Tinexyl®. [Figure 29] Figure 29 shows Subject 13 at Day 0, 2 weeks, and 4 weeks after the use of Tinexyl®.

Mode for Carrying Out the Invention

[0008] Formulation The formulation is for topical use. That is, the formulation is for application to the nails and / or the skin around the nails.

[0009] The formulation is liquid. The formulation is aqueous, that is, it contains water. The formulation is a cosmetic formulation.

[0010] Polymer The polymer contains (or consists of) 3 to 100 amino acids as a single polymer or a mixture thereof.

[0011] A polymer may contain (or consist of) 3, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, or 100 amino acids, or any range of amino acids within these numbers. For example, a polymer may contain (or consist of) 20-60 amino acids or 25-55 amino acids. A polymer is acyclic. A polymer is a linear polymer or a branched linear polymer. That is, a polymer means an acyclic chain of amino acids, which may be branched or unbranched.

[0012] In the case of a mixture, the polymer may contain or consist of shorter polymers, e.g., shorter polymers with a length of 3-20 or 3-15 amino acids, and longer polymers, e.g., polymers with 30 or more amino acids. For example, the first polymer may have 3-15 or 3-20 amino acids, and the second polymer may have 20-100 or 30-100 amino acids.

[0013] The amino acids in a polymer may be D-amino acids or L-amino acids. For example, the amino acids in a polymer may be 90% or 95%, 98% or 99% L-amino acids. The definition of a polymer also includes salts of the above amino acids, isomers (isomers relating to structure, stereochemistry, conformation and arrangement), peptidomimetics, structural analogs, and their naturally occurring (e.g., post-translational modification) or chemically modified (including, but not limited to, phosphorylation, glycosylation, sulfonylation and / or hydroxylation).

[0014] The formulation may contain 0.0001 to 80% polymer. For example, 0.05, 0.1, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20%. For example, 5 to 15%, or 8 to 12%. The percentage is expressed as weight-to-volume (w / v). That is, the weight of the polymer (grams) is divided by the volume of the final solution (milliliters), and multiplied by 100. Typically, polymers are produced by first dissolving the polymer in water, and then diluting the polymer-water solution with liquefied PEG to the desired concentration in the final solution.

[0015] The polymer may contain (or be composed of) at least 50% cationic amino acids. Cationic amino acids are arginine, histidine, and lysine. The polymer may contain (or be composed of) at least 50% arginine, or 50% histidine, or 50% lysine, or the 50% may be a mixture of two or more of these cationic amino acids. The percentages here are the number of cationic amino acids in the polymer divided by the total number of amino acids in the polymer.

[0016] The polymer may be a polyarginine polymer, i.e., a polymer containing (or consisting of) 60, 70, 80, 90, or 100% arginine. For example, the polymer may contain (or consist of) 20, 30, 40, 50, 60, 70, 80, 90, or 100% arginine.

[0017] replacement If the polymer is a polyarginine polymer, one polyarginine molecule may be substituted with another amino acid. Alternatively, two, three, four, or five polyarginine molecules may be substituted. In other words, one to five substitutions are performed on the polyarginine background (assuming no substitutions).

[0018] Conservative amino acid substitutions, i.e., substitutions of amino acids with similar chemical and physical properties, are often used. For example, in conservative amino acid substitutions, arginine is substituted with lysine or isoleucine. Histidine and other cationic amino acids (including unnaturally occurring cationic amino acids) can also be substituted.

[0019] Lactate ions Lactate ions (or lactate salts) may also be present in the formulation. Lactate ions may act as keratin-degrading agents and / or nail brighteners.

[0020] Lactate ions may be present in amounts of 0.005 to 10% w / v.

[0021] PEG PEG is a polymer of polyethylene glycol, or ethylene oxide. The molecular weight of a polymer is usually indicated by the number following PEG. For example, PEG8000 has a molecular weight of 8000 g / mol.

[0022] PEG can be PEG1000-6000. PEG can be PEG1000, PEG1500, PEG2000, PEG3000, PEG3350, PEG4000, PEG5000, PEG6000, PEG7000, or PEG8000. These are PEGs with an average molecular weight (mwt) of 4000 g / mol or 3000 g / mol, respectively, or PEGs with a higher average molecular weight, such as PEG6000 or PEG8000.

[0023] The concentration of PEG is expressed as %(v / v). In its solid state, PEG dissolves in H2O. Low molecular weight PEG (e.g., less than PEG1000) is liquid at room temperature. PEG1000 and heavier PEGs are usually all solid at room temperature (i.e., below 30°C).

[0024] The formulation may contain any of the above PEGs in amounts from 10% to 80%. For example, the formulation may contain 20% to 70% PEG, or 30% to 60% PEG, or 40% to 60% PEG. For example, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, or 80% v / v. For example, PEG with a 45-50% v / v rating.

[0025] The formulation may contain PEG up to approximately 60% v / v, for example, approximately 40% to 60% v / v PEG. In one embodiment, the formulation contains 40% to 55% v / v PEG. In another embodiment, the formulation contains 45% to 50% v / v PEG.

[0026] The formulation may contain PEG4000 at approximately 47.5 to 55% v / v or PEG3000 at approximately 47.5 to 60% v / v. PEG may contain approximately 50% v / v PEG4000, or PEG may contain approximately 52.5% v / v PEG3000.

[0027] The PEG formulation, in addition to its fast-drying properties, allows the user to see a film of the solution on the nail. This allows the user (client: or subject) to notice any unapplied (or missed) areas and reapply (or repaint) to ensure complete coverage of the nail surface. In other words, the formulation is a film-forming formulation. A film refers to a thin, visible, non-sticky (or non-greasy) layer that forms on the surface of the nail.

[0028] Nail brighteners and other nail enhancers (or nail strengtheners) or additives Nail brightener (or nail polish) or biotin may be added. Nail brighteners may contain vitamin C, ascorbate ions (or ascorbate salts), and / or citric acid.

[0029] Pigments may also be added to the formulation. The pigments can be of any color.

[0030] Keratin decomposing agent Keratin hydrolysates are compounds that can break down keratin. For example, urea.

[0031] PEG and polymer combination An example formulation includes 1-20% polymer (w / v), for example, a polymer of 20-100 amino acids (e.g., arginine), optionally a polymer of 25-55 amino acids (e.g., arginine), and 40-80% PEG1000-PEG8000 (v / v).

[0032] For example, the formulation may contain 1-20% polymer (w / v), which contains or consists of 20-100 amino acid polyarginines, and the formulation may further contain PEG500-PEG8000, and the formulation may contain approximately 40-60% (v / v) PEG.

[0033] The formulation may contain 5-10% polymer (w / v) and 40-55% PEG1000-8000 (v / v).

[0034] The formulation may contain 5-12.5% ​​polymer (w / v) and 40-55% PEG1000-6000 (v / v).

[0035] The formulation may contain 5-15% polymer (w / v) and 40-55% PEG1000-3000 (v / v).

[0036] The above formulations may contain polymers of 20 to 100 amino acids, preferably 25 to 60 amino acids. For example: The formulation may contain a polyarginine polymer of 5-10% polymer (w / v) and 40-55% PEG1000-8000 (v / v) and 25-60 arginine. The formulation may contain 5-12.5% ​​polymer (w / v) and 40-55% PEG1000-6000 (v / v) and 25-60 amino acid polyarginine polymers. The formulation may contain 5-15% polymer (w / v) and 40-55% PEG1000-3000 (v / v) and 25-60 amino acid polyarginine polymers.

[0037] If polymers of 20 to 100 amino acids are provided, any of the above combinations may be provided, which may be replaced by a combination of a shorter polymer of 3 to 20 or 3 to 15 amino acids and a longer polymer of 20 to 100 amino acids.

[0038] For example, the polymer mixture may contain a) a polyarginine polymer of 20-40 arginine, e.g., 30 arginine, and b) a polyarginine polymer of 40-60 arginine, e.g., 50 arginine. Thus, the formulation may contain 30-mer and 50-mer (both polyarginine and both unbranched). The formulation may also contain 40-55% PEG4000 (v / v), e.g., 50% PEG4000. The formulation may additionally contain lactate ions (or lactate salts), e.g., about 5% lactate ions.

[0039] Therefore, the example formulations are: a) A mixture of 30-mer polyarginine and 50-mer polyarginine, wherein the amount of each of these polymers is approximately 0.05% w / v; b) PEG4000, wherein the amount of PEG is approximately 50% w / v; and c) Lactate ions, wherein the amount of said lactate ions is about 5% w / v. It may include.

[0040] The formulation may have a pH adjusted to be within the range of 2 to 5, or optionally within the range of 3 to 4.

[0041] The formulations described herein are self-preserving and therefore may not contain preservatives. For example, the formulations may not contain urea and / or parabens.

[0042] Therefore, the example formulations are: a) A mixture of 30-mer polyarginine and 50-mer polyarginine, wherein the amount of each of these polymers is approximately 0.05% w / v; b) PEG4000, wherein the amount of PEG is approximately 50% w / v; c) Lactate ions, wherein the amount of said lactate ions is about 5% w / v. It may contain [specific substances], has a pH of 2-5, optionally within the range of 3-4, and furthermore, does not contain urea and / or parabens.

[0043] unit Examples of methods for preparing formulations: To prepare a 10% (w / v) polymer solution (for illustrative purposes only) in 50% (v / v) PEG4000, all materials to be used were preheated to 37°C in an incubator before commencing the compounding process to ensure and facilitate accurate dispensing (or distribution or preparation) of the liquefied PEG. The polymer was prepared as an aqueous solution in sterile deionized water (purity 18 MΩ) at a concentration of 400 mg / ml, filtered through a 0.22 μm syringe filter to ensure sterility, and preheated to 37°C immediately before use in compounding. 20 g of PEG4000 (solid at room temperature, melting point 53-58°C) was placed in a glass beaker in a microwave oven and dissolved at low power until a clear solution was obtained. The temperature of the PEG4000 never exceeded 70°C at any point. After liquefaction, 5 ml of PEG4000 was transferred to a sterile glass universal bottle and equilibrated at 37°C in a 37°C incubator for 30-60 minutes. 2.5 ml of polymer (400 mg / ml, 40% (w / v)) was added, and the volume was adjusted to 10 ml with pre-warmed sterile deionized water (purity 18 MΩ). The solution was stored in a dark place at room temperature (18-20°C).

[0044] For PEGs with higher MW values, such as PEG1000 or higher, these are supplied as solids. Therefore, the concentration can also be stated as w / v, which contains the same amount of PEG as v / v. For example, the above formulations containing PEGs exceeding PEG1000, such as PEG4000, can be stated as w / v in the formulation.

[0045] device Typically, topical formulations are applied (or spread) using an applicator such as a dropper, pipette, sponge, or brush.

[0046] A device (or apparatus) may be used to apply (or coat) the formulation to the nail. The device may be, for example, a bottle with a brush applicator.

[0047] The applicator for applying (or coating) the treatment can be a brush or a sponge. Advantageously, the use of an applicator allows for the application of a controlled amount of the formulation to the nail. Even more advantageously, the use of a sponge or brush allows for the even, or nearly even, distribution of the formulation across the nail surface.

[0048] beauty method Compounds can be used in cosmetic procedures to treat (or treat) the nails. Cosmetic (or cosmetic) refers to non-medical (or non-medical) treatments to improve the appearance of the nails. For example, compounds can improve the condition of the nails by treating, for example, brittleness and / or dryness. In addition to or instead of this, compounds can treat onychodystrophy (abnormal changes in the shape, color, texture, and / or growth of the nails). For example, compounds can treat discoloration of the nails. Compounds can also be used to moisturize (or hydrate) the nails and / or improve their smoothness and / or reduce nail thickness.

[0049] use "Use" refers to cosmetic use. This includes, for example, use as a nail coating to improve the appearance of the nails by reducing nail hardness or discoloration, in accordance with the aforementioned improvements in cosmetic methods.

[0050] Throughout this specification, unless otherwise specified in the context, the terms “include” or “contain,” or variations such as “include” or “contain,” “contains” or “contains,” are understood to mean that the method or kit includes an integer or group of integers as specified, but not that other integers or groups of integers are excluded. The gist of the invention, including a given element, is intended to be extended to alternative embodiments that “consist” or “essentially consist” of the relevant element.

[0051] Where technically appropriate, embodiments of the present invention can be combined.

[0052] Each document, reference, patent application, or patent cited herein is explicitly incorporated into this specification by reference, and the reader should read and consider it as part of this specification. The absence of repetition of any document, reference, patent application, or patent cited herein is solely for the sake of brevity. References to any cited material or information contained herein should not be understood as an acknowledgment that such material or information was common knowledge or known in any country. [Examples]

[0053] The gist of this invention will be explained only as an example, with reference to the following experiment.

[0054] The Tinexyl® formulation used in the experiment (per 10 liters): [Table 1]

[0055] Manufacturing process: 1. Measure the dried ingredients before use. 2. Dissolve PEG4000 in a mixture of purified water and 90% of lactic acid at approximately 60°C until homogeneous. Maintain the solution at approximately 50-60°C until the next step. 3. Mix TXYL30 (Figure 20) with a portion of the purified water beforehand, then add it to the solution from step 2 and mix until uniform. Maintain the solution at approximately 50-55°C until the next step. 4. Pre-mix TXYL50 (Figure 20) with a portion of the purified water, then add it to the solution from step 3 and mix until homogeneous. Adjust the pH of the solution (with sodium hydroxide) to a range of approximately 3.75, and maintain the solution at approximately 50-55°C until the next step. 5. Dilute the solution with purified water to the required volume and cool it to 25°C while mixing. 6. Transfer the bulk solution to an appropriate storage container before filling it into cosmetic containers.

[0056] Experimental Example 1: A linear polymer containing PEG moisturizes and penetrates the nail. To ensure maximum exposure, the inventors excised human toenails and immersed them in the solution. Four nail fragments (or pieces) were used for each treatment group (including Tinexyl®, water, and a control product). The experiment was conducted for five days, with weights measured daily at 0, 2, 4 hours, and then up to 96 hours (day 5).

[0057] result: As shown in Figure 1, the weight of the fragments increased over time, indicating that Tinexyl® penetrates the nails, moisturizes them, and is far more effective than the comparison product.

[0058] The comparative product (Kerasal®) contained propylene glycol, urea, glycerin, lactic acid, water, sodium hydroxide, and disodium EDTA.

[0059] Experimental Example 2: Further testing shows that penetration and moisturizing progress beyond the 5-day mark observed in Experimental Example 1. The purpose of this experiment was to investigate the penetration, moisturizing, and speed of action of the Tinexyl® product. For each treatment group, the product was applied once daily to four toenail fragments and weighed for 28 days (20 days excluding weekends).

[0060] result: The results are shown in Figure 2, which indicates that weight increased at least until day 20.

[0061] Experimental Example 3: Showing the rate of penetration compared to a comparative product. The purpose of this experiment is to repeat Experiment 1 to determine whether Tinexyl® penetrates and moistens excised human toenail fragments when they are immersed in the solution for an extended period (so that immersion ensures maximum exposure to the product).

[0062] This experiment included Tinexyl® (6 fragments), water (5 fragments), and the comparison product Kerasal® (5 fragments). The experiment was conducted over 6 days, with weights measured daily at 0, 2, 4, 6 hours, and then at 24, 48, 72, and 144 hours (over 6 days).

[0063] The comparative product was selected as the product most similar to Tinexyl® on the market, and it contains water and lactic acid, but uses a different film-forming agent than PEG, and, importantly, does not contain polymers.

[0064] result: As shown in Figure 3, the weight of the fragments increased over time, indicating that Tinexyl® penetrates and moisturizes the nails, proving to be far more effective than the comparison product. While the comparison product began to show weight increase after 72 hours, Tinexyl® began showing weight increase after just 2 hours.

[0065] Experimental Example 4: Tinexyl® demonstrates that it penetrates and moisturizes the nails within minutes. In this experiment (a repetition of Experiment Example 3, but using shorter time points), evaluations were performed at shorter time points (0-2 hours) and only Tinexyl® (6 fragments) was included.

[0066] The experiment was conducted for two hours, and weights were measured at 0 hours, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes.

[0067] result: As shown in Figure 4, the weight of the fragments increased over time, indicating that Tinexyl® penetrated the nails and moisturized them.

[0068] Experimental Example 5: The formulation demonstrates no antimicrobial contamination. The inventors conducted challenge tests (or loading tests) to identify the efficacy of the components in the formulation and to confirm that microbial penetration was minimal or nonexistent. Tinexyl®, prepared by NovaBiotics, was subjected to 1 × 10⁻⁶ samples containing five different microorganisms: E. coli, S. aureus, P. aeruginosa, C. albicans, and A. brasiliensis. 5 Samples were inoculated at a concentration of cfu / ml, and then at specific time points of 7, 14, 21, and 28 days, the samples were inoculated (or seeded) three times onto agar plates, and the microbial count was measured. This method (detailed in ISO 11930) was followed, but bacteria were inoculated on Müller-Hinton agar, and fungi and yeasts were inoculated on Sabouraud dextrose agar. Experiments also included time points of 8 and 12 weeks after inoculation.

[0069] result: Figure 5 shows that this formulation does not support microbial growth.

[0070] Experimental Example 6: Formulation of linear polymer and PEG improves the appearance of nails. The purpose of this experiment was to evaluate the overall appearance of excised toenails immersed in Tinexyl® for up to 28 days. Immersion ensured maximum exposure to the product. Images were taken before exposure and every 7 days after exposure. This allowed for the visualization of improvements in the appearance of the excised toenails, including nail texture, discoloration, gloss, and nail condition.

[0071] result: As shown in Figures 6, 7, 9-19, and 21-29, after using Tinexyl®, improvements were observed in the condition, appearance, and texture of the nails, as well as reduced discoloration and increased nail shine.

Claims

1. A topical water-based cosmetic nail formulation, a) an acyclic polymer or a mixture of acyclic polymers, wherein each acyclic polymer in the acyclic polymer or the mixture contains 3 to 100 amino acids; and b) Polyethylene glycol (PEG) 500 to PEG8000 Nail polish formulations that include [this ingredient].

2. The nail compound according to claim 1, further comprising lactate ions.

3. The nail compound according to claims 1 to 2, wherein the polymer comprises at least 50% cationic amino acids, and optionally 100% cationic amino acids.

4. The nail compound according to any one of claims 1 to 3, wherein the polymer comprises at least 50% arginine, and optionally the polymer comprises at least 60%, at least 70%, at least 80%, or at least 90% arginine.

5. The nail compound according to any one of claims 1 to 4, wherein the polymer in the polymer or mixture is a polyarginine polymer having 1 to 5 amino acid substitutions optionally.

6. The nail compound according to any one of claims 1 to 5, wherein the polymer a) comprises 20 to 60 amino acids in length, optionally comprising 25 to 55 amino acids, or b) the mixture comprises a polymer of 3 to 15 amino acids and a polymer of 20 to 100 amino acids.

7. The nail compound according to any one of claims 1 to 6, wherein the PEG has an average molecular weight of 1,000 to 6,000, and optionally the PEG has an average molecular weight of 4,000 to 6,000.

8. The nail compound according to any one of claims 1 to 7, wherein the compound contains 10 to 80% v / v PEG, and optionally the compound contains 40 to 60% v / v PEG.

9. The nail compound according to any one of claims 1 to 8, further comprising a nail brightener, wherein the nail brightener is optionally vitamin C, ascorbate ions, and / or citric acid.

10. The nail compound according to any one of claims 1 to 9, further comprising a keratin-degrading agent, wherein the keratin-degrading agent is optionally urea.

11. The topical aqueous cosmetic nail formulation according to any one of claims 1 to 10, wherein the acyclic polymer or mixture of acyclic polymers comprises at least 50% cationic amino acids, optionally 100% cationic amino acids, and the formulation further comprises lactate ions.

12. The topical aqueous cosmetic nail compound according to claim 11, wherein the mixture of acyclic polymers comprises i) a polyarginine polymer of 40 to 60 parts arginine and optionally 50 parts arginine, and ii) a polyarginine polymer of 20 to 40 parts arginine and optionally 30 parts arginine, and the PEG is PEG 4000.

13. A cosmetic method for improving the appearance of a nail, comprising applying a formulation according to any one of claims 1 to 12 to the nail and / or the skin surrounding the nail.

14. Use of the formulation according to any one of claims 1 to 12 on nails.

15. The use of the compound to the nail according to claim 14, wherein the use of the compound to the nail improves the appearance of the nail.

16. The cosmetic method according to claim 13 or the use according to claim 15, wherein the improvement in the appearance of the nail is due to a) moisturizing, b) reducing discoloration, c) reducing brittleness / improving smoothness, and / or d) reducing thickness.

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