Macrocyclic compounds, methods for producing the same, and uses

Abstract

Compounds represented by formula (I) or their stereoisomers, or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising such compounds, as well as their use in the manufacture of agents for the prevention and / or treatment of diseases or conditions related to RAS protein activity (e.g., cancer). TIFF2026530065000310.tif12497

Description

[Technical Field]

[0001] This disclosure belongs to the pharmaceutical field and specifically relates to macrocyclic compounds that can inhibit the activity of RAS proteins, as well as methods for producing and using the same.

[0002] This application claims priority to the following prior applications: the patent application number 202311130834X filed with the China National Intellectual Property Administration on September 1, 2023; the patent application number 2024104662832 filed with the China National Intellectual Property Administration on April 17, 2024; the patent application number 2024106442663 filed with the China National Intellectual Property Administration on May 22, 2024; the patent application number 2024108449718 filed with the China National Intellectual Property Administration on June 26, 2024; and the patent application number 2024111714441 filed with the China National Intellectual Property Administration on August 23, 2024. The five prior applications described above are incorporated into this application in their entirety by reference. [Background technology]

[0003] The RAS gene (Rat sarcoma viral oncogene homolog) encodes a protein belonging to the low molecular weight GTP hydrolase family, with a molecular weight of approximately 21 kDa. The mammalian RAS family includes three members: HRAS, KRAS, and NRAS, which function as molecular switches in various intracellular signaling processes. When RAS is bound to GDP, it is in an inactive state, either dormant or off. When cells are exposed to certain proliferative stimuli, RAS is induced to exchange bound GDP for GTP and become further activated. Subsequently, it recruits and activates other downstream target proteins (e.g., Raf and PI3K) to promote cell proliferation. The RAS protein has endogenous activity to hydrolyze GTP to GDP (therefore converting itself into an inactive state), but the rate of this conversion is relatively low. However, when it binds to GTPase-activated protein (GAP), the interaction between the two significantly accelerates the rate at which the RAS protein converts GTP to GDP. As a result, the RAS can be rapidly restored to an inactive state at the end of cell stimulation, thereby blocking the signaling pathway.

[0004] RAS gene mutations are found in approximately 30% of human tumors, with KRAS mutations being the most common, accounting for about 85%, while NRAS and HRAS mutations account for about 12% and 3%, respectively. KRAS mutations are frequently found in pancreatic cancer (86%), colorectal cancer (41%), and lung cancer (32%), NRAS mutations are mainly seen in malignant melanoma and acute myeloid leukemia, and HRAS mutations are mainly seen in bladder cancer and head and neck cancer. RAS gene mutations in tumors mainly occur in the form of point mutations. To date, more than 150 different RAS point mutations have been identified, with mutations at positions G12, G13, and Q61 being the most common. These pathogenic mutations usually affect the interaction between RAS and GAP and the endogenous GTP hydrolase activity of RAS, resulting in the mutant RAS protein existing primarily as an active form bound to GTP within cells. This leads to a sustained activation of the signaling pathway mediated by the RAS, resulting in a loss of control over cell proliferation and ultimately promoting tumorigenesis.

[0005] Currently, AMG510 and MRTX849 are approved and marketed as drugs targeting the KRAS G12C mutation and are used to treat non-small cell lung cancer with the KRAS G12C mutation. However, there are no approved targeted drugs for KRAS G12D and KRAS G12V mutations, which frequently occur in pancreatic and colorectal cancers, or for NRAS and HRAS mutations, which are common in malignant melanoma and head and neck cancers. Therefore, the development of highly efficient inhibitors targeting multiple RAS mutations has significant clinical value and is both a point of interest and a challenge in the field of new drug development. [Overview of the project] [Problems that the invention aims to solve]

[0006] This disclosure provides a series of RAS inhibitors that can inhibit RAS activity through non-covalent bonding between the RAS protein and the cytoplasmic chaperone protein (e.g., cyclophilin A) by inducing the formation of a high-affinity ternary complex between the RAS protein and the cytoplasmic chaperone protein.

[0007] The RAS inhibitors described herein are expected to have advantages such as high activity and low toxic side effects, as well as good physicochemical properties and drug discovery potential. [Means for solving the problem]

[0008] A first aspect of this disclosure provides a compound represented by formula (I), or a stable deuterated derivative, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. TIFF2026530065000002.tif11499 (I) Of these, ring A is TIFF2026530065000003.tif74154 And, TIFF2026530065000004.tif6684 W1 is a phenyl group, a 5 or 6-membered heteroaryl group, or a 5 or 6-membered heterocyclyl group, wherein one or two ring atoms of the 5 or 6-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur, one or two ring atoms of the 5 or 6-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur, and the 5 or 6-membered heterocyclyl group is a fully saturated heterocyclyl group or a partially unsaturated heterocyclyl group, or among them, W1 is CH, C, or N, W2 is CH, C, or N, and W3 is CR 13 , O, S, N or NH, and W4 is CR 13 It is O, S, N, or NH, and W5 is absent, or O or CR. 14 And, TIFF2026530065000005.tif2938 indicates the bonding position to the left portion, W6 is CR 13 or selected from N, X is TIFF2026530065000006.tif49116 , Y1 is N or CH, wherein N may be oxidized to form (N + -O - ), Y2 is N or CH, wherein N may be oxidized to form (N + -O - ), R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl group, R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl group, or R 42 and R 43 together with the carbon atoms linked thereto form a substituted or unsubstituted C 3-6 cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclyl group, R 40 is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl group, R 41 is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl group, or R 40 and R 41 are bonded to form -CH2- or -CH2CH2-, wherein -CH2- or -CH2CH2- is optionally substituted with one or more groups selected from deuterium, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, and deuterated C 1-6 alkyl, when ring A is TIFF2026530065000007.tif7566 , L1 is -N(R 00 )C(=O)-, -N(R 00 )C(=O)-O-, -C 1-4 alkyl-N(R00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 An aryl-, -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl-, an -L2-substituted or unsubstituted 8 or 10-membered bicyclic heteroaryl-, or an -L2-substituted or unsubstituted 3- to 8-membered heterocyclyl-, where L2 is C 3-6 Cycloalkyl group, 3-8 membered heterocyclyl group, -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -CR 09 =CR 10 -, -N(R 00 )C(=O)- or -N(R 00 )C(=S)-, Ring A TIFF2026530065000008.tif97117 If that is the case, If at least one of W1, W2, W3, W4, and W5 is a heteroatom selected from O, S, N, or NH, then L1 is -N(R 00 )C(=O)-, -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-, substituted or unsubstituted C3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 It is an aryl-, -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl- or a -L2-substituted or unsubstituted 3- to 8-membered heterocyclyl-, L2 is -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -CR 09 =CR 10 -, -N(R 00 )C(=O)- or -N(R 00 )C(=S)-, Or, If W1 and W2 are both C, and W3, W4, and W5 are all CH, then L1 is -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -N(R 00 )C(=O)-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O- or -- substituted or unsubstituted C 2-6 It is an alkenyl-O-, R 00 is hydrogen or C 1-6 It is an alkyl group, R1 is hydrogen, deuterium, halogen, hydroxyl group, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R 3a is C 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, R 4ais substituted or unsubstituted C 1-6 alkyl group, a substituted or unsubstituted C 3-6 cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclyl group, R5 is hydrogen, NR 01 R 02 , -C(R 05 )R 03 R 04 , -C 1-4 alkyl-NR 01 R 02 , -C 1-4 alkyl-C(R 05 )R 03 R 04 , -C 1-4 alkyl-C(=O)-NR 01 R 02 , -C 1-4 alkyl-C(=O)-C(R 05 )R 03 R 04 , -C 1-4 alkyl-C(=O)-C 1-4 alkyl-NR 01 R 02 , -C 1-4 alkyl-C(=O)-C 1-4 alkyl-C(R 05 )R 03 R 04 , -C 1-4 alkyl-N(R 06 )C(=O)-NR 01 R 02 , -C 1-4 alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 , -C 1-4 alkyl-N(R 06 )C(=O)-C 1-4 alkyl-NR 01 R 02 , -C 1-4 alkyl-N(R 06 )C(=O)-C 1-4 alkyl-C(R 05 )R 03 R 04 , -O-C 1-4 alkyl-NR 01 R02 -OC 1-4 Alkyl-C(R 05 )R 03 R 04 -OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 , -OC(R 05 )R 03 R 04 , -C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(R 05 )R 03 R 04 , -N(R 06 )C(=O)-NR 01 R 02 , -N(R 06 )C(=O)-C(R 05 )R 03 R 04 , -C 2-4 Alkinyl-NR 01 R 02 , -C 2-4 Alkinyl-C(=O)-NR 01 R 02 , -C 2-4 Alkinyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkinyl-NR 01 R 02 , -C 1-4 Alkyl-C 2-4 Alkinyl-C(R 05 )R 03 R 04 , -C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 , -C 2-4 Alkinyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R02 -CH=CR 01 R 02 , -C 2-4 Alkenil-NR 01 R 02 , -C 2-4 Alkenyl-C(R) 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkenil-NR 01 R 02 , -C 1-4 Alkyl-C 2-4 Alkenyl-C(R) 05 )R 03 R 04 , -C 2-4 Alkenil-C 1-4 Alkyl-NR 01 R 02 , -C 2-4 Alkenil-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkenil-C 1-4 Alkyl-NR 01 R 02 -C=CR 03 R 04 -OC 1-4 Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl groups, -OC 1-4 Alkyl-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -OC 1-4 Alkyl-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -O-substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, -O-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -O-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 ), -N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 ), -S(=O)(R 06 )(=NR06 ), -S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 ), -S(=O)2(-C 1-4 Alkyl-NR 01 R 02 ), -S(=O)(-C 1-4 Alkyl-NR 01 R 02 ), -S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 ), -S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 ), -C 2-4 Alkynyl-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, -C 2-4 Alkynyl-substituted or unsubstituted 8-10 membered bicyclic heteroaryl group, -C 2-4 Alkynyl-substituted or unsubstituted 6-12 member heteroaryl group condensed heterocyclyl group, substituted or unsubstituted C 6-10 Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, substituted or unsubstituted C 6-10 Aryl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl group, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl group, substituted or unsubstituted C 6-10 Aryl-C 1-4 Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl group, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl-C 1-4 Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl group, substituted or unsubstituted C 6-10 3- to 8-membered monocyclic heterocyclyl groups with aryl group condensation substitution or unsubstituted, substituted or unsubstituted 5 or 6-membered monocyclic heterocyclyl groups with 5 or 6-membered monocyclic heteroaryl group condensation substitution or unsubstituted, substituted or unsubstituted C 6-10 Aryl-C 1-4 Alkyl-NR 01 R 02Alternatively, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl -- C 1-4 Alkyl-NR 01 R 02 And, R 01 , R 02 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from alkynyl groups, or R 01 , R 02 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, or substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups. R 03 , R 04 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from the alkynyl groups, of which the above C 1-6 Alkyl alkyl group, C 1-6 Two hydrogen atoms on the same carbon atom on the alkoxy group can be arbitrarily selected to form -(CH2) simultaneously. j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or R 03 , R 04 These, together with the carbon atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups, substituted or unsubstituted 5 or 6 member monocyclic heteroaryl groups, or substituted or unsubstituted 8-10 member bicyclic heteroaryl groups. R 05 Hydrogen, deuterium, halogens, deuterated C 1-6 Alkyl alkyl group or C1-6 It is an alkyl group, R 06 is hydrogen, deuterium or C 1-6 It is an alkyl group, Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 ), -S(=O)(R 07 )(R 08 ), -S(=O)2(R 07 )(R 08 ), -P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkyl-NR6-S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkyl-N=S(=O)(R 07 )(R 08 ) or R 11 And R 12 is hydrogen, C 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, Alternatively, Y3, R 12 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted nitrogen-containing 3-8 membered heterocyclyl groups, where one ring atom of the nitrogen-containing 3-8 membered heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. R6 is either substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 11This is a substituted or unsubstituted 3-10 member heterocyclyl group, a substituted or unsubstituted 5 or 6 member monocyclic heteroaryl group, a substituted or unsubstituted 8-10 member bicyclic heteroaryl group, a substituted or unsubstituted 6-12 member heteroaryl group condensed cycloalkyl group, a substituted or unsubstituted 6-12 member heteroaryl group condensed heterocyclyl group, a substituted or unsubstituted 7-12 member bicyclic heterocyclyl group, or a substituted or unsubstituted 5-15 member tricyclic heterocyclyl group. R 07 C is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 It is a cycloalkyl group, and the above substitutions are deuterium, C 1-6 Alkyl alkyl group, C 1-6 This means that the group is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of heteroalkyl groups and 5- or 6-membered monocyclic heteroaryl groups. R 08 C is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 It is a cycloalkyl group, and the above substitutions are deuterium, C 1-6 Alkyl alkyl group, C 1-6 This means that the group is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of heteroalkyl groups and 5- or 6-membered monocyclic heteroaryl groups. R 09 C is hydrogen, deuterium, halogen, or substituted or unsubstituted C 1-6 It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. R 10 C is hydrogen, deuterium, halogen, or substituted or unsubstituted C 1-6 It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. Y5 is either O or S. Y4 is either O or S. R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C1-6 Heteroalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Alkynyl group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 13 C is hydrogen, halogen, substituted or unsubstituted 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is an alkoxy group, R 14 C is hydrogen, halogen, or substituted or unsubstituted C 1-6 It is an alkyl group, or In W4 and W5, R 13 and R 14 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Cycloalkyl groups, substituted or unsubstituted C 6-10 It forms an aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 3 to 8-membered heterocyclyl group, or R in W5 14 And R3, together with the atoms linked to them, form a substituted or unsubstituted nitrogen-containing 4-8 member monocyclic heterocyclyl group, where one ring atom of the above nitrogen-containing 4-8 member monocyclic heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, or R in W6 13 And R3, together with the atoms linked to them, form a substituted or unsubstituted nitrogen-containing 3- to 8-membered monocyclic heterocyclyl group or a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, wherein one ring atom of the above nitrogen-containing 3- to 8-membered monocyclic heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. In each of the above groups, the above substitution means that each group is independently substituted with 1, 2, 3, 4, 5, or 6 groups selected from the S1 group, and each of the S1 group groups is independently -SF5, deuterium, oxo (=O), thio (=S), =CR e R f ,=NR e , halogen, cyano group, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Alkoxy group, C 3-20 Cycloalkyl group, 3-20 membered heterocyclyl group, C 6-14 Aryl group, 5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -OC 3-20 Cycloalkyl group, -O-3~20 member heterocyclyl group, -OC 6-14 Aryl group, -O-5 or 6-membered monocyclic heteroaryl group, -O-8 to 10-membered bicyclic heteroaryl group, -C≡CC 3-20 Cycloalkyl group, -C≡C-3~20 member heterocyclyl group, -C≡CC 6-14 Aryl group, -C≡C-5 or 6-membered monocyclic heteroaryl group, -C≡C-8 to 10-membered bicyclic heteroaryl group, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C≡CC 1-4 Alkyl-C 6-14 Aryl group, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C≡CC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-OC3-20 Cycloalkyl groups, -C 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C 1-4 Alkyl-O-3~20 member heterocyclyl group, -C 1-4 Alkyl-C 6-14 Aryl group, -C 1-4 Alkyl-OC 6-14 Aryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-hydroxyl group, -OC 1-4 Alkyl-cyano group, -OC 1-4 Alkyl-C 1-6 alkyl group, -OC 1-4 Alkyl-C 1-6 Alkoxy group, -OC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -OC 1-4 Alkyl-O-3~20 member heterocyclyl group, -OC 1-4 Alkyl-C 6-14 Aryl group, -OC 1-4 Alkyl-OC 6-14 Aryl group, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-20 Cycloalkyl group, -S(=O)2-3~20 member heterocyclyl group, -C(=O)OC 1-6 Alkyl alkyl group, -C(=O)OC3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-20 Cycloalkyl groups, -C(=O)-C 6-14 Aryl group, -NR a1 R b1 -C(=O)-NR a1 R b1 -C(=O)-NR d1 -C 1-4 Alkyl-R c1 , -OR c1 , -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-S(=O)2-3~20 member heterocyclyl group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 6-14 Aryl group, -C(=O)-5 or 6-membered monocyclic heteroaryl group, -C(=O)-8 to 10-membered bicyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl-3 to 20-membered heterocyclyl group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl group, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-NR a1 R b1 , -C 1-4 Alkyl-C(=O)-NR a1 R b1-C≡CC(=O)-NR a1 R b1 -C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 , -C 1-4 Alkyl-OR c1 , -C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2,-C 1-4 Alkyl-NR d1 -C(=O)-R c1 , -C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-R c1 , -C 1-4 Alkyl-S(=O)2-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 , -NR d1 -C(=O)-R c1 , -NR d1 -C(=O)-C 1-4 Alkyl-R c1 , -NR d1 -C(=O)-NR a1 R b1 , -NR d1 -S(=O)2-R c1 -S(=O)2-NR a1 R b1 , -NR d1 -S(=O)2-NR a1 R b1 and -P(=O)-(C 1-6 Selected from the group consisting of alkyl)2, of which the above C 1-6 Alkyl alkyl group, above C 1-6 Alkoxy group, above C 2-6 Alkenyl group, above C 2-6Each alkynyl group is independently and optionally substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the above C 3-20 Cycloalkyl group, the above 3-20 membered heterocyclyl group, the above C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently and arbitrarily substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R a1 , R b1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C3-6 Monocyclic cycloalkyl group, -S(=O)2-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-S(=O)2-3~6 member monocyclic heterocyclyl group, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-6 It is a monocyclic cycloalkyl group or a -C(=O)-3 to 6-membered monocyclic heterocyclyl group, of which the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2 and -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, or Each R a1 and R b1 These, together with the nitrogen atom linked to them, form a 3-20 membered heterocyclyl group, and each of these 3-20 membered heterocyclyl groups can independently and arbitrarily be a halogen, hydroxyl group, carboxyl group, nitro group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2 and -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each R d1 H and C are independent of each other. 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, each R c1 H and C are independent of each other. 1-6 Alkyl alkyl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-NR a1 R b1 , halogenated C 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, or -C 1-4 It is an alkyl-8~10 membered bicyclic heteroaryl group, and the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl group, C 3-6 Monocyclic cycloalkyl groups, halogenated C 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2 or -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each S2 group group is independently deuterium, oxo (=O), thio (=S), and =CR. e R f ,=NR e , halogen, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-(C=O)-NHC 1-6 Alkyl group, -(C=O)-N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -(C=O)C 1-6Selected from the group consisting of alkyl groups and -SF5, In each of the above groups, -C 1-4 Alkyl- is unsubstituted, or -C 1-4 Alkyl - The 1, 2, 3, or 4 hydrogen atoms on the alkyl group are each independently a halogen, cyano group, hydroxyl group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl group, -CH2-hydroxy group, -CH2-cyano group, phenyl group, C 3-6 Substituted with a group selected from monocyclic cycloalkyl groups, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously form -(CH2) j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously =CR e R f Replaced by, In each of the above groups, R e These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, R f These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-8 membered heterocyclyl group, 3-10 membered heterocyclyl group, or 3-8 membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and the above C 1-6One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7-12 membered bicyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3-20 membered heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6 membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8-10 membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. A heteroatom selected from nitrogen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-6 member monocyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 5-15 member tricyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 6-12 member heteroaryl group condensed cycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 6-12 member heteroaryl group condensed heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, If the ring atom is a sulfur atom, that sulfur atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above, If the ring atom is a phosphorus atom, that phosphorus atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above.

[0009] In this specification, with other parts of the molecule TIFF2026530065000009.tif6957 To further explain the bonding position, TIFF2026530065000010.tif6586 It can be displayed as follows: TIFF2026530065000011.tif3040 The asterisk in this context indicates a connection with the left-hand portion. TIFF2026530065000012.tif3846 The tilde in this symbol indicates a bond with other parts of the molecule.

[0010] In one embodiment, R 40 is hydrogen, R 41 It is hydrogen.

[0011] A first aspect of this disclosure provides a compound represented by formula (ID), or a stable deuterated derivative, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. TIFF2026530065000013.tif143124 (ID) Of these, ring A is TIFF2026530065000014.tif80165 And, TIFF2026530065000015.tif7290 W1 is a phenyl group, a 5 or 6-membered monocyclic heteroaryl group, or a 5 or 6-membered monocyclic heterocyclyl group, wherein one or two ring atoms of the 5 or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur, and the 5 or 6-membered monocyclic heterocyclyl group is a fully saturated heterocyclyl group or a partially unsaturated heterocyclyl group, or among these, W1 is CH, C, or N, W2 is CH, C, or N, and W3 is CR 13 , O, S, N or NH, and W4 is CR 13 , O, S, N or NH, and the above W5 is absent, or O or CR 14 And, TIFF2026530065000016.tif3140 This indicates the connection point with the left side. W6 is CR 13 or N, X is TIFF2026530065000017.tif55131 And, Y1 is either N or CH, and of these, N is oxidized to (N + -O - ) is also acceptable, Y2 is either N or CH, and of these, N is oxidized to (N + -O - ) is also acceptable, R 42 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, R 43 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or R 42 and R 43 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Forming monocyclic cycloalkyl groups or substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl groups, R 40 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, R 41 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or R 40 and R 41 These combine to form -CH2- or -CH2CH2-, of which -CH2- or -CH2CH2- can optionally be deuterium, halogen, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Substituted with one or more groups selected from alkyl groups, Ring A TIFF2026530065000018.tif9182 If so, L1 is -N(R 00 )C(=O)-, -N(R00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-, substituted or unsubstituted C 3-6 Monocyclic cycloalkyl groups, substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl groups, substituted or unsubstituted C 6-10 Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 An aryl-, -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl-, an -L2-substituted or unsubstituted 8 or 10-membered bicyclic heteroaryl-, or an -L2-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclyl-, where L2 is C 3-6 Monocyclic cycloalkyl groups, 3- to 8-membered monocyclic heterocyclyl groups, -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -CR 09 =CR 10 -, -N(R 00 )C(=O)- or -N(R 00 )C(=S)-, Ring A TIFF2026530065000019.tif88102 If that is the case, If at least one of W1, W2, W3, W4, and W5 is a heteroatom selected from O, S, N, or NH, then L1 is -N(R 00 )C(=O)-, -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-, substituted or unsubstituted C 3-6 Monocyclic cycloalkyl groups, substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl groups, substituted or unsubstituted C 6-10 Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 It is an aryl-, -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl- or an -L2-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclyl-, L2 is -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -CR 09 =CR 10 -, -N(R 00 )C(=O)- or -N(R 00 )C(=S)-, Or, If W1 and W2 are both C, and W3, W4, and W5 are all CH, then L1 is -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -N(R 00 )C(=O)-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O- or -- substituted or unsubstituted C 2-6 It is an alkenyl-O-, R 00 is hydrogen or C 1-6 It is an alkyl group, R1 is hydrogen, deuterium, halogen, hydroxyl group, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R 3a is C1-6 Alkyl or deuterated C 1-6 It is an alkyl group, R 4a is a substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 A monocyclic cycloalkyl group or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl group, R5 is hydrogen, NR 01 R 02 , -C(R 05 )R 03 R 04 , -C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C(=O)-NR 01 R 02 , -C 1-4 alkyl-C(=O)-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 , -C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05)R 03 R 04 -OC 1-4 Alkyl-NR 01 R 02 -OC 1-4 Alkyl-C(R 05 )R 03 R 04 -OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 , -OC(R 05 )R 03 R 04 , -C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(R 05 )R 03 R 04 , -N(R 06 )C(=O)-NR 01 R 02 , -N(R 06 )C(=O)-C(R 05 )R 03 R 04 , -C 2-4 Alkinyl-NR 01 R 02 , -C 2-4 Alkinyl-C(=O)-NR 01 R 02 , -C 2-4 Alkinyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkinyl-NR 01 R 02 , -C 1-4 Alkyl-C 2-4 Alkinyl-C(R 05 )R 03 R 04 , -C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 , -C 2-4 Alkinyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4Alkyl-C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 -CH=CR 01 R 02 , -C 2-4 Alkenil-NR 01 R 02 , -C 2-4 Alkenyl-C(R) 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkenil-NR 01 R 02 , -C 1-4 Alkyl-C 2-4 Alkenyl-C(R) 05 )R 03 R 04 , -C 2-4 Alkenil-C 1-4 Alkyl-NR 01 R 02 , -C 2-4 Alkenil-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkenil-C 1-4 Alkyl-NR 01 R 02 -C=CR 03 R 04 -OC 1-4 Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl groups, -OC 1-4 Alkyl-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -OC 1-4 Alkyl-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -O-substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, -O-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -O-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 ), -N(R 06 )-S(=O)(-C 1-4Alkyl-NR 01 R 02 ), -S(=O)(R 06 )(=N-R 06 ), -S(=O)(-C 1-4 alkyl-NR 01 R 02 )(=N-R 06 ), -S(=O)2(-C 1-4 alkyl-NR 01 R 02 ), -S(=O)(-C 1-4 alkyl-NR 01 R 02 ), -S(=O)2(-C 1-4 alkyl-C(R 05 )R 03 R 04 ), -S(=O)(-C 1-4 alkyl-C(R 05 )R 03 R 04 ), -C 2-4 alkynyl-substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl group, -C 2-4 alkynyl-substituted or unsubstituted 8-10 membered bicyclic heteroaryl group or -C 2-4 alkynyl-substituted or unsubstituted 6-12 membered heteroaryl-fused heterocyclyl group, substituted or unsubstituted C 6-10 aryl group, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl group, substituted or unsubstituted 8-10 membered bicyclic heteroaryl group, substituted or unsubstituted C 6-10 aryl-substituted or unsubstituted 3-8 membered monocyclic heterocyclyl group, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl-substituted or unsubstituted 3-8 membered monocyclic heterocyclyl group, substituted or unsubstituted C 6-10 aryl-C 1-4 alkyl-substituted or unsubstituted 3-8 membered monocyclic heterocyclyl group, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl-C 1-4 alkyl-substituted or unsubstituted 3-8 membered monocyclic heterocyclyl group, substituted or unsubstituted C 6-10 aryl-fused substituted or unsubstituted 3-8 membered monocyclic heterocyclyl group, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl-fused substituted or unsubstituted 3-8 membered monocyclic heterocyclyl group, substituted or unsubstituted C6-10 Aryl-C 1-4 Alkyl-NR 01 R 02、 Substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl -- C 1-4 Alkyl-NR 01 R 02 And, R 01 , R 02 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 3-6 Monocyclic cycloalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from alkynyl groups, or R 01 , R 02 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups. R 03 , R 04 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from the alkynyl groups, of which the above C 1-6 Alkyl alkyl group, C 1-6 Two hydrogen atoms on the same carbon atom on the alkoxy group can be arbitrarily selected to form -(CH2) simultaneously. j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or R 03 , R 04 These, together with the carbon atoms linked to them, form substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, substituted or unsubstituted 5 or 6 membered monocyclic heteroaryl groups, or substituted or unsubstituted 8-10 membered bicyclic heteroaryl groups. R 05 is hydrogen, deuterium, halogen, deuterated C 1-6 alkyl group or C 1-6 alkyl group, R 06 is hydrogen, deuterium or C 1-6 alkyl group, Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=N-R 08 ), -S(=O)(R 07 )(R 08 ), -S(=O)2(R 07 )(R 08 ), -P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 alkyl-NR6-S(=O)(R 07 )(=N-R 08 ), -C(=O)-C 1-4 alkyl-N=S(=O)(R 07 )(R 08 ) or R 11 , R 12 is hydrogen, C 1-6 alkyl group or deuterated C 1-6 alkyl group, or Y3 and R 12 together with the nitrogen atom linked thereto form a substituted or unsubstituted nitrogen-containing 3- to 8-membered monocyclic heterocyclyl group, one ring atom of said nitrogen-containing 3- to 8-membered monocyclic heterocyclyl group is a nitrogen atom, and optionally one or more (for example, 1, 2 or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus, R6 is a substituted or unsubstituted C 1-6 alkyl group, a substituted or unsubstituted C 1-6 heteroalkyl group, a substituted or unsubstituted C 3-6 monocyclic cycloalkyl group, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl group, a substituted or unsubstituted C 6-10 aryl group, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl group or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl group, R 11These are substituted or unsubstituted 3-10 member monocyclic heterocyclyl groups, substituted or unsubstituted 5 or 6 member monocyclic heteroaryl groups, substituted or unsubstituted 8-10 member bicyclic heteroaryl groups, substituted or unsubstituted 6-12 member heteroaryl group condensed cycloalkyl groups, substituted or unsubstituted 6-12 member heteroaryl group condensed heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups. R 07 C is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 It is a monocyclic cycloalkyl group, and the above substitutions are deuterium, C 1-6 Alkyl alkyl group, C 1-6 This means that the group is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of heteroalkyl groups and 5- or 6-membered monocyclic heteroaryl groups. R 08 C is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 It is a monocyclic cycloalkyl group, and the above substitutions are deuterium, C 1-6 Alkyl alkyl group, C 1-6 This means that the group is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of heteroalkyl groups and 5- or 6-membered monocyclic heteroaryl groups. R 09 C is hydrogen, deuterium, halogen, substituted or unsubstituted C 1-6 It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. R 10 C is hydrogen, deuterium, halogen, substituted or unsubstituted C 1-6 It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. Y5 is either O or S. Y4 is either O or S. R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C1-6 Heteroalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Alkynyl group, substituted or unsubstituted C 3-6 Monocyclic cycloalkyl groups, substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 13 C is hydrogen, halogen, substituted or unsubstituted 1-6 alkoxy group, substituted or unsubstituted C 1-6 It is an alkyl group, R 14 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or In W4 and W5, R 13 and R 14 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Monocyclic cycloalkyl groups, substituted or unsubstituted C 6-10 Forms an aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 3 to 8-membered monocyclic heterocyclyl group, or R in W5 14 And R3, together with the atoms linked to them, form a substituted or unsubstituted nitrogen-containing 4-8 member monocyclic heterocyclyl group, where one ring atom of the above nitrogen-containing 4-8 member monocyclic heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, or R in W6 13 And R3, together with the atoms linked to them, form a substituted or unsubstituted nitrogen-containing 3- to 8-membered monocyclic heterocyclyl group, or a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, wherein one ring atom of the above nitrogen-containing 3- to 8-membered monocyclic heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. In each of the above groups, substitution means that each group is independently substituted with 1, 2, 3, 4, 5, or 6 groups selected from the S1 group, and each of the S1 group groups is independently -SF5, deuterium, oxo (=O), thio (=S), =CR e R f ,=NR e , halogen, cyano group, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Alkoxy group, C 3-20 Cycloalkyl group, 3-20 membered heterocyclyl group, C 6-14 Aryl group, 5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -OC 3-20 Cycloalkyl group, -O-3~20 member heterocyclyl group, -OC 6-14 Aryl group, -O-5 or 6-membered monocyclic heteroaryl group, -O-8 to 10-membered bicyclic heteroaryl group, -C≡CC 3-20 Cycloalkyl group, -C≡C-3~20 member heterocyclyl group, -C≡CC 6-14 Aryl group, -C≡C-5 or 6-membered monocyclic heteroaryl group, -C≡C-8 to 10-membered bicyclic heteroaryl group, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C≡CC 1-4 Alkyl-C 6-14 Aryl group, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C≡CC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-OC3-20 Cycloalkyl groups, -C 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C 1-4 Alkyl-O-3~20 member heterocyclyl group, -C 1-4 Alkyl-C 6-14 Aryl group, -C 1-4 Alkyl-OC 6-14 Aryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-hydroxyl group, -OC 1-4 Alkyl-cyano group, -OC 1-4 Alkyl-C 1-6 alkyl group, -OC 1-4 Alkyl-C 1-6 Alkoxy group, -OC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -OC 1-4 Alkyl-O-3~20 member heterocyclyl group, -OC 1-4 Alkyl-C 6-14 Aryl group, -OC 1-4 Alkyl-OC 6-14 Aryl group, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-20 Cycloalkyl group, -S(=O)2-3~20 member heterocyclyl group, -C(=O)OC 1-6 Alkyl alkyl group, -C(=O)OC3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-20 Cycloalkyl groups, -C(=O)-C 6-14 Aryl group, -NR a1 R b1 -C(=O)-NR a1 R b1 -C(=O)-NR d1 -C 1-4 Alkyl-R c1 , -OR c1 , -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-S(=O)2-3~20 member heterocyclyl group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 6-14 Aryl group, -C(=O)-5 or 6-membered monocyclic heteroaryl group, -C(=O)-8 to 10-membered bicyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl-3 to 20-membered heterocyclyl group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl group, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-NR a1 R b1 , -C 1-4 Alkyl-C(=O)-NR a1 R b1-C≡CC(=O)-NR a1 R b1 -C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 , -C 1-4 Alkyl-OR c1 , -C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2,-C 1-4 Alkyl-NR d1 -C(=O)-R c1 , -C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-R c1 , -C 1-4 Alkyl-S(=O)2-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 , -NR d1 -C(=O)-R c1 , -NR d1 -C(=O)-C 1-4 Alkyl-R c1 , -NR d1 -C(=O)-NR a1 R b1 , -NR d1 -S(=O)2-R c1 -S(=O)2-NR a1 R b1 , -NR d1 -S(=O)2-NR a1 R b1 -P(=O)-(C 1-6 Selected from the group consisting of alkyl)2, of which the above C 1-6 Alkyl alkyl group, above C 1-6 Alkoxy group, above C 2-6 Alkenyl group, above C 2-6Each alkynyl group is independently and optionally substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the above C 3-20 Cycloalkyl group, the above 3-20 membered heterocyclyl group, the above C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently and arbitrarily substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R a1 , R b1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C3-6 Monocyclic cycloalkyl group, -S(=O)2-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-S(=O)2-3~6 member monocyclic heterocyclyl group, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-6 The monocyclic cycloalkyl group and the -C(=O)-3 to 6-membered monocyclic heterocyclyl group, of which the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, or Each R a1 and R b1 These, together with the nitrogen atom linked to them, form a 3-20 membered heterocyclyl group, and each of these 3-20 membered heterocyclyl groups can independently and arbitrarily be a halogen, hydroxyl group, carboxyl group, nitro group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each R d1 H and C are independent of each other. 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, each R c1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, or -C 1-4 It is an alkyl-8~10 membered bicyclic heteroaryl group, and the above C3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each S2 group group is independently deuterium, oxo (=O), thio (=S), and =CR. e R f ,=NR e , halogen, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-(C=O)-NHC 1-6 Alkyl group, -(C=O)-N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -(C=O)C 1-6 Selected from the group consisting of alkyl groups and -SF5, In each of the above groups, -C 1-4 Alkyl- is unsubstituted, or -C 1-4Alkyl - The 1, 2, 3, or 4 hydrogen atoms on the alkyl group are each independently a halogen, cyano group, hydroxyl group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Substituted with a group selected from alkyl groups, -CH2-hydroxy groups, -CH2-cyano groups, or phenyl groups, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously form -(CH2) j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously =CR e R f Replaced by, In each of the above groups, R e These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, R f These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-6 membered monocyclic heterocyclyl group, 3-10 membered monocyclic heterocyclyl group, or 3-8 membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and the above C 1-6One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7-12 membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3-20 membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6 membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; and the 8-10 membered bicyclic heteroaryl group... One or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5-15 member tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6-12 member heteroaryl group condensed cycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6-12 member heteroaryl group condensed heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; If the ring atom is a sulfur atom, that sulfur atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above, If the ring atom is a phosphorus atom, that phosphorus atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above.

[0012] A first aspect of this disclosure provides a compound represented by formula (IC), or a stable deuterated derivative, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. TIFF2026530065000020.tif10289(IC) Eventually, Ring A is TIFF2026530065000021.tif7997 or TIFF2026530065000022.tif7669 And, TIFF2026530065000023.tif6582 is a phenyl group, a 5 or 6-membered heteroaryl group, a 5 or 6-membered heterocyclyl group, wherein one or two ring atoms of the 5 or 6-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur, and the 5 or 6-membered heterocyclyl group is either a fully saturated heterocyclyl group or a partially unsaturated heterocyclyl group. TIFF2026530065000024.tif4560 This indicates the connection point with the left side. Of these, W1 and W2 are each independently selected from C or N. W3 and W4 are each independently CR 13 , selected from O, S, N or NH, W6 is CR 13 Or selected from N, W5 does not exist, or O or CR 14 Selected from, X is TIFF2026530065000025.tif8768 , TIFF2026530065000026.tif9173 or TIFF2026530065000027.tif8081 And, Y1 is either N or CH, and of these, N is oxidized to (N + -O - ) is also acceptable, Y2 is either N or CH, and of these, N is oxidized to (N + -O - ) is also acceptable, R 42C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, R 43 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or R 42 and R 43 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Forming a cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, R 40 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, R 41 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or R 40 and R 41 These combine to form -CH2- or -CH2CH2-, of which -CH2- or -CH2CH2- can optionally be deuterium, halogen, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Substituted with one or more groups selected from alkyl groups, Ring A TIFF2026530065000028.tif8374 If so, L1 is -N(R 00 )C(=O)-, -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 An aryl-, -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl- or -L2-substituted or unsubstituted 3- to 8-membered heterocyclyl-, where L2 is C 3-6 Cycloalkyl group, 3-8 membered heterocyclyl group, -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -CR 09 =CR 10 -, -N(R 00 )C(=O)- or -N(R 00 )C(=S)-, Ring A TIFF2026530065000029.tif96119 If that is the case, If at least one of W1, W2, W3, W4, and W5 is a heteroatom selected from O, S, N, or NH, then L1 is -N(R 00 )C(=O)-, -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 It is an aryl-, -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl- or a -L2-substituted or unsubstituted 3- to 8-membered heterocyclyl-, L2 is -O-, -C 1-4 alkyl-, -N(R 00)-, -C(=O)-, -CR 09 =CR 10 -, -N(R 00 )C(=O)- or -N(R 00 )C(=S)-, Or, If W1 and W2 are both C, and W3, W4, and W5 are all CH, then L1 is -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -N(R 00 )C(=O)-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O- or -- substituted or unsubstituted C 2-6 It is an alkenyl-O-, R 00 is hydrogen or C 1-6 It is an alkyl group, R1 is hydrogen, deuterium, halogen, hydroxyl group, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R 3a is C 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Alkynyl group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 4ais a substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 A cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, R5 is hydrogen, NR 01 R 02 , -C(R 05 )R 03 R 04 , -C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C(=O)-NR 01 R 02 , -C 1-4 alkyl-C(=O)-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 , -C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 -OC 1-4 Alkyl-NR 01 R02 -OC 1-4 Alkyl-C(R 05 )R 03 R 04 -OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 , -OC(R 05 )R 03 R 04 , -C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(R 05 )R 03 R 04 , -N(R 06 )C(=O)-NR 01 R 02 , -N(R 06 )C(=O)-C(R 05 )R 03 R 04 , -C 2-4 Alkinyl-NR 01 R 02 , -C 2-4 Alkinyl-C(=O)-NR 01 R 02 , -C 2-4 Alkinyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkinyl-NR 01 R 02 , -C 1-4 Alkyl-C 2-4 Alkinyl-C(R 05 )R 03 R 04 , -C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 , -C 2-4 Alkinyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R02 -CH=CR 01 R 02 , -C 2-4 Alkenil-NR 01 R 02 , -C 2-4 Alkenyl-C(R) 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkenil-NR 01 R 02 , -C 1-4 Alkyl-C 2-4 Alkenyl-C(R) 05 )R 03 R 04 , -C 2-4 Alkenil-C 1-4 Alkyl-NR 01 R 02 , -C 2-4 Alkenil-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkenil-C 1-4 Alkyl-NR 01 R 02 -C=CR 03 R 04 -OC 1-4 Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl groups, -OC 1-4 Alkyl-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -OC 1-4 Alkyl-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -O-substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, -O-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -O-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 ), -N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 ), -S(=O)(R 06 )(=NR06 ), -S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 ), -S(=O)2(-C 1-4 Alkyl-NR 01 R 02 ), -S(=O)(-C 1-4 Alkyl-NR 01 R 02 )-,-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 ), -S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 ) and R 01 , R 02 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from alkynyl groups, or R 01 , R 02 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups. R 03 , R 04 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from the alkynyl groups, of which the above C 1-6 Alkyl alkyl group, C 1-6 Two hydrogen atoms on the same carbon atom on the alkoxy group can be arbitrarily selected to form -(CH2) simultaneously. j- is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or R 03 , R 04 These, together with the carbon atoms linked to them, form substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, substituted or unsubstituted 5 or 6 membered monocyclic heteroaryl groups, or substituted or unsubstituted 8-10 membered bicyclic heteroaryl groups. R 05 Hydrogen, deuterium, halogens, deuterated C 1-6 Alkyl alkyl group or C 1-6 It is an alkyl group, R 06 is hydrogen, deuterium or C 1-6 It is an alkyl group, Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 ), -S(=O)(R 07 )(R 08 ), -S(=O)2(R 07 )(R 08 ), -P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkyl-NR6-S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkyl-N=S(=O)(R 07 )(R 08 ) or R 11 And R 12 is hydrogen, C 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, Alternatively, Y3, R 12 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted nitrogen-containing 3-8 membered heterocyclyl groups, where one ring atom of the nitrogen-containing 3-8 membered heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. R6 is either substituted or unsubstituted C1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 11 These are substituted or unsubstituted 3-10 member heterocyclyl groups, substituted or unsubstituted 5 or 6 member monocyclic heteroaryl groups, substituted or unsubstituted 8-10 member bicyclic heteroaryl groups, substituted or unsubstituted 6-12 member heteroaryl group condensed cycloalkyl groups, substituted or unsubstituted 6-12 member heteroaryl group condensed heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups. R 07 C is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 It is a cycloalkyl group, and the above substitutions are deuterium, C 1-6 Alkyl alkyl group, C 1-6 This means that the group is substituted with one or more groups (e.g., 1, 2, 3, or 4) selected from the group consisting of heteroalkyl groups and 5- or 6-membered monocyclic heteroaryl groups. R 08 C is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 It is a cycloalkyl group, and the above substitutions are deuterium, C 1-6 Alkyl alkyl group, C 1-6 This means that the group is substituted with one or more groups (e.g., 1, 2, 3, or 4) selected from the group consisting of heteroalkyl groups and 5- or 6-membered monocyclic heteroaryl groups. R 09 C is hydrogen, deuterium, halogen, substituted or unsubstituted C 1-6 It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. R 10C is hydrogen, deuterium, halogen, substituted or unsubstituted C 1-6 It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. Y5 is either O or S. Y4 is either O or S. R 13 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, R 14 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or R 13 and R 14 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Forming a cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, In each of the above groups, the above substitution means that each group is independently substituted with 1, 2, 3, 4, 5, or 6 groups selected from the S1 group, and each of the S1 group groups is independently -SF5, deuterium, oxo (=O), thio (=S), =CR e R f ,=NR e , halogen, cyano group, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Alkoxy group, C 3-20 Cycloalkyl group, 3-20 membered heterocyclyl group, C 6-14 Aryl group, 5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -OC 3-20 Cycloalkyl group, -O-3~20 member heterocyclyl group, -OC 6-14 Aryl group, -O-5 or 6-membered monocyclic heteroaryl group, -O-8 to 10-membered bicyclic heteroaryl group, -C≡CC 3-20 Cycloalkyl group, -C≡C-3~20 member heterocyclyl group, -C≡CC 6-14Aryl group, -C≡C-5 or 6-membered monocyclic heteroaryl group, -C≡C-8 to 10-membered bicyclic heteroaryl group, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C≡CC 1-4 Alkyl-C 6-14 Aryl group, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C≡CC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C 1-4 Alkyl-O-3~20 member heterocyclyl group, -C 1-4 Alkyl-C 6-14 Aryl group, -C 1-4 Alkyl-OC 6-14 Aryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-hydroxyl group, -OC 1-4 Alkyl-cyano group, -OC 1-4 Alkyl-C 1-6 alkyl group, -OC 1-4 Alkyl-C 1-6 Alkoxy group, -OC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-OC3-20 Cycloalkyl groups, -OC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -OC 1-4 Alkyl-O-3~20 member heterocyclyl group, -OC 1-4 Alkyl-C 6-14 Aryl group, -OC 1-4 Alkyl-OC 6-14 Aryl group, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-20 Cycloalkyl group, -S(=O)2-3~20 member heterocyclyl group, -C(=O)OC 1-6 Alkyl alkyl group, -C(=O)OC 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-20 Cycloalkyl groups, -C(=O)-C 6-14 Aryl group, -NR a1 R b1 -C(=O)-NR a1 R b1 -C(=O)-NR d1 -C 1-4 Alkyl-R c1 , -OR c1 , -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-S(=O)2-3~20 member heterocyclyl group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl alkyl group, -C 1-4Alkyl-C(=O)-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 6-14 Aryl group, -C(=O)-5 or 6-membered monocyclic heteroaryl group, -C(=O)-8 to 10-membered bicyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl-3 to 20-membered heterocyclyl group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl group, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-NR a1 R b1 , -C 1-4 Alkyl-C(=O)-NR a1 R b1 -C≡CC(=O)-NR a1 R b1 -C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 , -C 1-4 Alkyl-OR c1 , -C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2,-C 1-4 Alkyl-NR d1 -C(=O)-R c1 , -C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-R c1 , -C 1-4 Alkyl-S(=O)2-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 , -NR d1-C(=O)-R c1 , -NR d1 -C(=O)-C 1-4 Alkyl-R c1 , -NR d1 -C(=O)-NR a1 R b1 , -NR d1 -S(=O)2-R c1 -S(=O)2-NR a1 R b1 , -NR d1 -S(=O)2-NR a1 R b1 -P(=O)-(C 1-6 Selected from the group consisting of alkyl)2, of which the above C 1-6 Alkyl alkyl group, above C 1-6 Alkoxy group, above C 2-6 Alkenyl group, above C 2-6 Each alkynyl group is independently and optionally substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the above C 3-20 Cycloalkyl group, the above 3-20 membered heterocyclyl group, the above C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently and arbitrarily substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R a1 , R b1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-6 Monocyclic cycloalkyl group, -S(=O)2-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-S(=O)2-3~6 member monocyclic heterocyclyl group, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-6 The monocyclic cycloalkyl group and the -C(=O)-3 to 6-membered monocyclic heterocyclyl group, of which the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, or Each R a1 and R b1 These, together with the nitrogen atom linked to them, form a 3-20 membered heterocyclyl group, and each of these 3-20 membered heterocyclyl groups can independently and arbitrarily be a halogen, hydroxyl group, carboxyl group, nitro group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each R d1 H and C are independent of each other. 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, each R c1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, or -C 1-4 It is an alkyl-8~10 membered bicyclic heteroaryl group, and the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each S2 group group is independently deuterium, oxo (=O), thio (=S), and =CR. e R f ,=NR e , halogen, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-(C=O)-NHC 1-6 Alkyl group, -(C=O)-N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -(C=O)C 1-6 Selected from the group consisting of alkyl groups and -SF5, In each of the above groups, -C 1-4 Alkyl- is unsubstituted, or -C 1-4 Alkyl - The 1, 2, 3, or 4 hydrogen atoms on the alkyl group are each independently a halogen, cyano group, hydroxyl group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Substituted with a group selected from alkyl groups, -CH2-hydroxy groups, -CH2-cyano groups, or phenyl groups, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously form -(CH2) j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously =CR e R f Replaced by, In each of the above groups, R e These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, R f These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-8 membered heterocyclyl group, 3-10 membered heterocyclyl group, or 3-8 membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and the above C 1-6 One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7-12 membered bicyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3-20 membered heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6 membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8-10 membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. A heteroatom selected from nitrogen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-6 member monocyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 5-15 member tricyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 6-12 member heteroaryl group condensed cycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 6-12 member heteroaryl group condensed heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, If the ring atom is a sulfur atom, that sulfur atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above, If the ring atom is a phosphorus atom, that phosphorus atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above.

[0013] A first aspect of this disclosure provides a compound represented by formula (IB), or a stable deuterated derivative, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. TIFF2026530065000030.tif134116 (IB) Eventually, Ring A is TIFF2026530065000031.tif8299 or TIFF2026530065000032.tif9382 And, TIFF2026530065000033.tif6179 is a phenyl group, a 5 or 6-membered heteroaryl group, or a 5 or 6-membered heterocyclyl group, wherein one or two ring atoms of the 5 or 6-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur, and one or two ring atoms of the 5 or 6-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur, and the 5 or 6-membered heterocyclyl group is a fully saturated heterocyclyl group or a partially unsaturated heterocyclyl group, or Of these, W1 and W2 are each independently selected from C or N. W3 and W4 are each independently CR 13 , selected from O, S, N or NH, W5 does not exist, or O or CR 14 Selected from, W6 is CR 13 Or selected from N, X is TIFF2026530065000034.tif8568 , TIFF2026530065000035.tif10279 or TIFF2026530065000036.tif8585 And, Y1 is either N or CH, and of these, N is oxidized to (N +-O - ) is also acceptable, Y2 is either N or CH, and of these, N is oxidized to (N + -O - ) is also acceptable, R 42 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, R 43 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or R 42 and R 43 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Forming a cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, R 40 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, R 41 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or R 40 and R 41 These combine to form -CH2- or -CH2CH2-, of which -CH2- or -CH2CH2- can be optionally substituted with a halogen. Ring A TIFF2026530065000037.tif8574 If so, L1 is -N(R 00 )C(=O)-, -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 An aryl-, -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl- or -L2-substituted or unsubstituted 3- to 8-membered heterocyclyl-, where L2 is -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -CR 09 =CR 10 -, -N(R 00 )C(=O)- or -N(R 00 )C(=S)-, Ring A TIFF2026530065000038.tif90108 If that is the case, If at least one of W1, W2, W3, W4, and W5 is a heteroatom selected from O, S, N, or NH, then L1 is -N(R 00 )C(=O)-, -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 It is an aryl-, -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl- or a -L2-substituted or unsubstituted 3- to 8-membered heterocyclyl-, L2 is -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -CR 09 =CR10 -, -N(R 00 )C(=O)- or -N(R 00 )C(=S)-, Or, If W1 and W2 are both C, and W3, W4, and W5 are all CH, then L1 is -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -N(R 00 )C(=O)-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O- or -- substituted or unsubstituted C 2-6 It is an alkenyl-O-, R 00 is hydrogen or C 1-6 It is an alkyl group, R1 is hydrogen, deuterium, halogen, hydroxyl group, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R 3a is C 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Alkynyl group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 4a is a substituted or unsubstituted C 1-6Alkyl alkyl group, substituted or unsubstituted C 3-6 A cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, R5 is hydrogen, NR 01 R 02 , -C(R 05 )R 03 R 04 , -C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C(=O)-NR 01 R 02 , -C 1-4 alkyl-C(=O)-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 , -C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 -OC 1-4 Alkyl-NR 01 R 02 -OC 1-4Alkyl-C(R 05 )R 03 R 04 -OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 , -OC(R 05 )R 03 R 04 , -C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(R 05 )R 03 R 04 , -N(R 06 )C(=O)-NR 01 R 02 , -N(R 06 )C(=O)-C(R 05 )R 03 R 04 , -C 2-4 Alkinyl-NR 01 R 02 , -C 2-4 Alkinyl-C(=O)-NR 01 R 02 , -C 2-4 Alkinyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkinyl-NR 01 R 02 , -C 1-4 Alkyl-C 2-4 Alkinyl-C(R 05 )R 03 R 04 , -C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 , -C 2-4 Alkinyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 -CH=CR 01 R02 , -C 2-4 Alkenil-NR 01 R 02 , -C 2-4 Alkenyl-C(R) 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkenil-NR 01 R 02 , -C 1-4 Alkyl-C 2-4 Alkenyl-C(R) 05 )R 03 R 04 , -C 2-4 Alkenil-C 1-4 Alkyl-NR 01 R 02 , -C 2-4 Alkenil-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkenil-C 1-4 Alkyl-NR 01 R 02 -C=CR 03 R 04 -OC 1-4 Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl groups, -OC 1-4 Alkyl-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -OC 1-4 Alkyl-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -O-substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, -O-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -O-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 ), -N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 ), -S(=O)(R 06 )(=NR 06 ), -S(=O)(-C 1-4Alkyl-NR 01 R 02 )(=NR 06 ), -S(=O)2(-C 1-4 Alkyl-NR 01 R 02 ), -S(=O)(-C 1-4 Alkyl-NR 01 R 02 )-,-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 ), -S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 ) and R 01 , R 02 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from alkynyl groups, or R 01 , R 02 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups. R 03 , R 04 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from alkynyl groups, of which, optionally, the above C 1-6 Alkyl alkyl group, C 1-6 Two hydrogen atoms bonded to the same carbon atom on an alkoxy group simultaneously form -(CH2) j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or R03 , R 04 These, together with the carbon atoms linked to them, form substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, substituted or unsubstituted 5 or 6 membered monocyclic heteroaryl groups, or substituted or unsubstituted 8-10 membered bicyclic heteroaryl groups. R 05 Hydrogen, deuterium, halogens, deuterated C 1-6 Alkyl alkyl group or C 1-6 It is an alkyl group, R 06 is hydrogen, deuterium or C 1-6 It is an alkyl group, Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 ), -S(=O)(R 07 )(R 08 ), -S(=O)2(R 07 )(R 08 ), -P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkyl-NR6-S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkyl-N=S(=O)(R 07 )(R 08 ) or R 11 And R 12 is hydrogen, C 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, Alternatively, Y3, R 12 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted nitrogen-containing 3-8 membered heterocyclyl groups, where one ring atom of the nitrogen-containing 3-8 membered heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. R6 is either substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 11 These are substituted or unsubstituted 3-10 member heterocyclyl groups, substituted or unsubstituted 5 or 6 member monocyclic heteroaryl groups, substituted or unsubstituted 8-10 member bicyclic heteroaryl groups, substituted or unsubstituted 6-12 member heteroaryl group condensed cycloalkyl groups, substituted or unsubstituted 6-12 member heteroaryl group condensed heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups. R 07 C is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 It is a cycloalkyl group, and the above substitutions are deuterium, C 1-6 Alkyl alkyl group, C 1-6 This means that the group is substituted with one or more groups (e.g., 1, 2, 3, or 4) selected from the group consisting of heteroalkyl groups and 5- or 6-membered monocyclic heteroaryl groups. R 08 C is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 It is a cycloalkyl group, and the above substitutions are deuterium, C 1-6 Alkyl alkyl group, C 1-6 This means that the group is substituted with one or more groups (e.g., 1, 2, 3, or 4) selected from the group consisting of heteroalkyl groups and 5- or 6-membered monocyclic heteroaryl groups. R 09 C is hydrogen, deuterium, halogen, substituted or unsubstituted C 1-6 It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. R 10 C is hydrogen, deuterium, halogen, substituted or unsubstituted C 1-6It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. Y5 is either O or S. Y4 is either O or S. R 13 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, R 14 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or R 13 and R 14 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Forming a cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, In each of the above groups, the above substitution means that each group is independently substituted with 1, 2, 3, 4, 5, or 6 groups selected from the S1 group, and each of the S1 group groups is independently deuterium, oxo (=O), thio (=S), and CR. e R f ,=NR e , halogen, cyano group, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Alkoxy group, C 3-20 Cycloalkyl group, 3-20 membered heterocyclyl group, C 6-14 Aryl group, 5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -OC 3-20 Cycloalkyl group, -O-3~20 member heterocyclyl group, -OC 6-14 Aryl group, -O-5 or 6-membered monocyclic heteroaryl group, -O-8 to 10-membered bicyclic heteroaryl group, -C≡CC 3-20 Cycloalkyl group, -C≡C-3~20 member heterocyclyl group, -C≡CC 6-14 Aryl group, -C≡C-5 or 6-membered monocyclic heteroaryl group, -C≡C-8 to 10-membered bicyclic heteroaryl group, -C≡CC 1-4 Alkyl-C 3-20Cycloalkyl groups, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C≡CC 1-4 Alkyl-C 6-14 Aryl group, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C≡CC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C 1-4 Alkyl-O-3~20 member heterocyclyl group, -C 1-4 Alkyl-C 6-14 Aryl group, -C 1-4 Alkyl-OC 6-14 Aryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-hydroxyl group, -OC 1-4 Alkyl-cyano group, -OC 1-4 Alkyl-C 1-6 alkyl group, -OC 1-4 Alkyl-C 1-6 Alkoxy group, -OC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -OC 1-4Alkyl-O-3~20 member heterocyclyl group, -OC 1-4 Alkyl-C 6-14 Aryl group, -OC 1-4 Alkyl-OC 6-14 Aryl group, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-20 Cycloalkyl group, -S(=O)2-3~20 member heterocyclyl group, -C(=O)OC 1-6 Alkyl alkyl group, -C(=O)OC 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-20 Cycloalkyl groups, -C(=O)-C 6-14 Aryl group, -NR a1 R b1 -C(=O)-NR a1 R b1 -C(=O)-NR d1 -C 1-4 Alkyl-R c1 , -OR c1 , -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-S(=O)2-3~20 member heterocyclyl group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 6-14Aryl group, -C(=O)-5 or 6-membered monocyclic heteroaryl group, -C(=O)-8 to 10-membered bicyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl-3 to 20-membered heterocyclyl group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl group, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-NR a1 R b1 , -C 1-4 Alkyl-C(=O)-NR a1 R b1 -C≡CC(=O)-NR a1 R b1 -C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 , -C 1-4 Alkyl-OR c1 , -C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2,-C 1-4 Alkyl-NR d1 -C(=O)-R c1 , -C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-R c1 , -C 1-4 Alkyl-S(=O)2-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 , -NR d1 -C(=O)-R c1 , -NR d1 -C(=O)-C 1-4 Alkyl-Rc1 , -NR d1 -C(=O)-NR a1 R b1 , -NR d1 -S(=O)2-R c1 -S(=O)2-NR a1 R b1 , -NR d1 -S(=O)2-NR a1 R b1 -P(=O)-(C 1-6 Selected from the group consisting of alkyl)2, of which the above C 1-6 Alkyl alkyl group, above C 1-6 Alkoxy group, above C 2-6 Alkenyl group, above C 2-6 Each alkynyl group is independently and optionally substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the above C 3-20 Cycloalkyl group, the above 3-20 membered heterocyclyl group, the above C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently and arbitrarily substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R a1 , R b1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-6 Monocyclic cycloalkyl group, -S(=O)2-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-S(=O)2-3~6 member monocyclic heterocyclyl group, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-6 The monocyclic cycloalkyl group and the -C(=O)-3 to 6-membered monocyclic heterocyclyl group, of which the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6Substituted with one or two groups selected from the group consisting of alkyl)2, or Each R a1 and R b1 These, together with the nitrogen atom linked to them, form a 3-20 membered heterocyclyl group, and each of these 3-20 membered heterocyclyl groups can independently and arbitrarily be a halogen, hydroxyl group, carboxyl group, nitro group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each R d1 H and C are independent of each other. 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, each R c1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, or -C 1-4 It is an alkyl-8~10 membered bicyclic heteroaryl group, and the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each S2 group group is independently deuterium, oxo (=O), thio (=S), and =CR. e R f ,=NR e , halogen, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-(C=O)-NHC 1-6 Alkyl group, -(C=O)-N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -(C=O)C 1-6 Selected from the group consisting of alkyl groups and -SF5, In each of the above groups, -C 1-4 Alkyl- is unsubstituted, or -C 1-4 Alkyl - The 1, 2, 3, or 4 hydrogen atoms on the alkyl group are each independently a halogen, cyano group, hydroxyl group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Substituted with a group selected from alkyl groups, -CH2-hydroxy groups, -CH2-cyano groups, or phenyl groups, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously form -(CH2) j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously =CR e R f Replaced by, In each of the above groups, R e These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, R f These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-8 membered heterocyclyl group, 3-10 membered heterocyclyl group, or 3-8 membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and the above C 1-6 One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7-12 membered bicyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3-20 membered heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6 membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8-10 membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. A heteroatom selected from nitrogen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-6 member monocyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 5-15 member tricyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 6-12 member heteroaryl group condensed cycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 6-12 member heteroaryl group condensed heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, If the ring atom is a sulfur atom, that sulfur atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above, If the ring atom is a phosphorus atom, that phosphorus atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above.

[0014] A first aspect of this disclosure provides a compound represented by formula (IA), or a stable deuterated derivative, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. TIFF2026530065000039.tif10189 (IA) Eventually, Ring A is TIFF2026530065000040.tif8198 or TIFF2026530065000041.tif8474 And, TIFF2026530065000042.tif6178 The group is a phenyl group, a 5 or 6-membered heteroaryl group, or a 5 or 6-membered heterocyclyl group, wherein one or two ring atoms of the 5 or 6-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur, and the 5 or 6-membered heterocyclyl group is a fully saturated heterocyclyl group or a partially unsaturated heterocyclyl group. Of these, W1 and W2 are each independently selected from C or N. W3 and W4 are each independently CR 13 , selected from O, S, N or NH, W5 does not exist, or O or CR 14 Selected from, W6 is CR 13 Or selected from N, X is TIFF2026530065000043.tif7860 , TIFF2026530065000044.tif9171 or TIFF2026530065000045.tif7271 And, Y1 is either N or CH, and of these, N is oxidized to (N+ -O - ) is also acceptable, Y2 is either N or CH, and of these, N is oxidized to (N + -O - ) is also acceptable, R 42 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, R 43 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or R 42 and R 43 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Forming a cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, Ring A TIFF2026530065000046.tif8675 If so, L1 is -N(R 00 )C(=O)-, -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 An aryl group, a -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a -L2-substituted or unsubstituted 3- to 8-membered heterocyclyl group, where L2 is -O- or -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -CR 09 =CR 10 -, -N(R00 )C(=O)- or -N(R 00 )C(=S)-, Ring A TIFF2026530065000047.tif88107 If that is the case, If at least one of W1, W2, W3, W4, and W5 is a heteroatom selected from O, S, N, or NH, then L1 is -N(R 00 )C(=O)-, -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 An aryl group, an -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or an -L2-substituted or unsubstituted 3 to 8-membered heterocyclyl group, L2 is -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -CR 09 =CR 10 -, -N(R 00 )C(=O)- or -N(R 00 )C(=S)-, Or, If W1 and W2 are both C, and W3, W4, and W5 are all CH, then L1 is N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-,--N(R 00 )C(=O)-C 1-4Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O- or -- substituted or unsubstituted C 2-6 It is an alkenyl-O-, Alternatively, if W1, W2, W3, W4, and W5 are all C or CH, then L1 is -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O- or -- substituted or unsubstituted C 2-6 It is an alkenyl-O- and R 00 is hydrogen or C 1-6 It is an alkyl group, R1 is hydrogen, deuterium, halogen, hydroxyl group, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R 3a is C 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, and R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Alkynyl group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 4a is a substituted or unsubstituted C 1-6Alkyl alkyl group, substituted or unsubstituted C 3-6 A cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, where R5 is hydrogen, NR 01 R 02 , -C(R 05 )R 03 R 04 , -C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C(=O)-NR 01 R 02 , -C 1-4 alkyl-C(=O)-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 , -C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 -OC 1-4 Alkyl-NR 01 R 02 -OC 1-4 Alkyl-C(R05 )R 03 R 04 -OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 , -OC(R 05 )R 03 R 04 , -C 1-4 Alkyl-NR 01 R 02 , -C 1-4 Alkyl-C(R 05 )R 03 R 04 , -N(R 06 )C(=O)-NR 01 R 02 , -N(R 06 )C(=O)-C(R 05 )R 03 R 04 , -C 2-4 Alkinyl-NR 01 R 02 , -C 2-4 Alkinyl-C(=O)-NR 01 R 02 , -C 2-4 Alkinyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkinyl-NR 01 R 02 , -C 1-4 Alkyl-C 2-4 Alkinyl-C(R 05 )R 03 R 04 , -C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 , -C 2-4 Alkinyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 -CH=CR 01 R 02, -C 2-4 Alkenil-NR 01 R 02 , -C 2-4 Alkenyl-C(R) 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkenil-NR 01 R 02 , -C 1-4 Alkyl-C 2-4 Alkenyl-C(R) 05 )R 03 R 04 , -C 2-4 Alkenil-C 1-4 Alkyl-NR 01 R 02 , -C 2-4 Alkenil-C 1-4 Alkyl-C(R 05 )R 03 R 04 , -C 1-4 Alkyl-C 2-4 Alkenil-C 1-4 Alkyl-NR 01 R 02 -C=CR 03 R 04 -OC 1-4 Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl groups, -OC 1-4 Alkyl-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -OC 1-4 Alkyl-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -O-substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, -O-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -O-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 ), -N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 ), -S(=O)(R 06 )(=NR 06 ), -S(=O)(-C 1-4 Alkyl-NR01 R 02 )-(=NR 06 ), -S(=O)2(-C 1-4 Alkyl-NR 01 R 02 ), -S(=O)(-C 1-4 Alkyl-NR 01 R 02 ), -S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 ), -S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 ) and R 01 , R 02 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from alkynyl groups, or R 01 , R 02 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups. R 03 , R 04 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from alkynyl groups, of which, optionally, the above C 1-6 Alkyl alkyl group, C 1-6 Two hydrogen atoms bonded to the same carbon atom on an alkoxy group simultaneously form -(CH2) j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or R03 , R 04 These, together with the carbon atoms linked to them, form substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, substituted or unsubstituted 5 or 6 membered monocyclic heteroaryl groups, or substituted or unsubstituted 8-10 membered bicyclic heteroaryl groups. R 05 Hydrogen, deuterium, halogens, deuterated C 1-6 Alkyl alkyl group or C 1-6 It is an alkyl group, R 06 is hydrogen, deuterium or C 1-6 It is an alkyl group, Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 ), -S(=O)(R 07 )(R 08 ), -S(=O)2(R 07 )(R 08 ), -P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkyl-NR6-S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkyl-N=S(=O)(R 07 )(R 08 ) or R 11 And R 12 is hydrogen, C 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, Alternatively, Y3, R 12 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted nitrogen-containing 3-8 membered heterocyclyl groups, where one ring atom of the nitrogen-containing 3-8 membered heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. R6 is either substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 11 These are substituted or unsubstituted 3-10 member heterocyclyl groups, substituted or unsubstituted 5 or 6 member monocyclic heteroaryl groups, substituted or unsubstituted 8-10 member bicyclic heteroaryl groups, substituted or unsubstituted 6-12 member heteroaryl group condensed cycloalkyl groups, substituted or unsubstituted 6-12 member heteroaryl group condensed heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups. R 07 C is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 It is a cycloalkyl group, and the above substitutions are deuterium, C 1-6 Alkyl alkyl group, C 1-6 This means that the group is substituted with one or more groups (e.g., 1, 2, 3, or 4) selected from the group consisting of heteroalkyl groups and 5- or 6-membered monocyclic heteroaryl groups. R 08 C is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 It is a cycloalkyl group, and the above substitutions are deuterium, C 1-6 Alkyl alkyl group, C 1-6 This means that the group is substituted with one or more groups (e.g., 1, 2, 3, or 4) selected from the group consisting of heteroalkyl groups and 5- or 6-membered monocyclic heteroaryl groups. R 09 C is hydrogen, deuterium, halogen, substituted or unsubstituted C 1-6 It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. R 10 C is hydrogen, deuterium, halogen, substituted or unsubstituted C 1-6It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. Y5 is either O or S. Y4 is either O or S. R 13 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, R 14 C is hydrogen, halogen, substituted or unsubstituted 1-6 It is an alkyl group, or R 13 and R 14 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Forming a cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, In each of the above groups, the above substitution means that each group is independently substituted with 1, 2, 3, 4, 5, or 6 groups selected from the S1 group, and each of the S1 group groups is independently deuterium, oxo (=O), thio (=S), and CR. e R f ,=NR e , halogen, cyano group, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Alkoxy group, C 3-20 Cycloalkyl group, 3-20 membered heterocyclyl group, C 6-14 Aryl group, 5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -OC 3-20 Cycloalkyl group, -O-3~20 member heterocyclyl group, -OC 6-14 Aryl group, -O-5 or 6-membered monocyclic heteroaryl group, -O-8 to 10-membered bicyclic heteroaryl group, -C≡CC 3-20 Cycloalkyl group, -C≡C-3~20 member heterocyclyl group, -C≡CC 6-14 Aryl group, -C≡C-5 or 6-membered monocyclic heteroaryl group, -C≡C-8 to 10-membered bicyclic heteroaryl group, -C≡CC 1-4 Alkyl-C 3-20Cycloalkyl groups, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C≡CC 1-4 Alkyl-C 6-14 Aryl group, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C≡CC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C 1-4 Alkyl-O-3~20 member heterocyclyl group, -C 1-4 Alkyl-C 6-14 Aryl group, -C 1-4 Alkyl-OC 6-14 Aryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-hydroxyl group, -OC 1-4 Alkyl-cyano group, -OC 1-4 Alkyl-C 1-6 alkyl group, -OC 1-4 Alkyl-C 1-6 Alkoxy group, -OC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -OC 1-4Alkyl-O-3~20 member heterocyclyl group, -OC 1-4 Alkyl-C 6-14 Aryl group, -OC 1-4 Alkyl-OC 6-14 Aryl group, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-20 Cycloalkyl group, -S(=O)2-3~20 member heterocyclyl group, -C(=O)OC 1-6 Alkyl alkyl group, -C(=O)OC 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-20 Cycloalkyl groups, -C(=O)-C 6-14 Aryl group, -NR a1 R b1 -C(=O)-NR a1 R b1 -C(=O)-NR d1 -C 1-4 Alkyl-R c1 , -OR c1 , -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-S(=O)2-3~20 member heterocyclyl group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 6-14Aryl group, -C(=O)-5 or 6-membered monocyclic heteroaryl group, -C(=O)-8 to 10-membered bicyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl-3 to 20-membered heterocyclyl group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl group, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-NR a1 R b1 , -C 1-4 Alkyl-C(=O)-NR a1 R b1 -C≡CC(=O)-NR a1 R b1 -C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 , -C 1-4 Alkyl-OR c1 , -C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2,-C 1-4 Alkyl-NR d1 -C(=O)-R c1 , -C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-R c1 , -C 1-4 Alkyl-S(=O)2-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 , -NR d1 -C(=O)-R c1 , -NR d1 -C(=O)-C 1-4 Alkyl-Rc1 , -NR d1 -C(=O)-NR a1 R b1 , -NR d1 -S(=O)2-R c1 -S(=O)2-NR a1 R b1 , -NR d1 -S(=O)2-NR a1 R b1 -P(=O)-(C 1-6 Selected from the group consisting of alkyl)2, of which the above C 1-6 Alkyl alkyl group, above C 1-6 Alkoxy group, above C 2-6 Alkenyl group, above C 2-6 Each alkynyl group is independently and optionally substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the above C 3-20 Cycloalkyl group, the above 3-20 membered heterocyclyl group, the above C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently and arbitrarily substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R a1 , R b1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-6 Monocyclic cycloalkyl group, -S(=O)2-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-S(=O)2-3~6 member monocyclic heterocyclyl group, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-6 The monocyclic cycloalkyl group and the -C(=O)-3 to 6-membered monocyclic heterocyclyl group, of which the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6Substituted with one or two groups selected from the group consisting of alkyl)2, or Each R a1 and R b1 These, together with the nitrogen atom linked to them, form a 3-20 membered heterocyclyl group, and each of these 3-20 membered heterocyclyl groups can independently and arbitrarily be a halogen, hydroxyl group, carboxyl group, nitro group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each R d1 H and C are independent of each other. 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, each R c1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, or -C 1-4 It is an alkyl-8~10 membered bicyclic heteroaryl group, and the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each S2 group group is independently deuterium, oxo (=O), thio (=S), and =CR. e R f ,=NR e , halogen, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-(C=O)-NHC 1-6 Alkyl group, -(C=O)-N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -(C=O)C 1-6 Selected from the group consisting of alkyl groups and -SF5, In each of the above groups, -C 1-4 Alkyl- is unsubstituted, or -C 1-4 Alkyl - The 1, 2, 3, or 4 hydrogen atoms on the alkyl group are each independently a halogen, cyano group, hydroxyl group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Substituted with a group selected from alkyl groups, -CH2-hydroxy groups, -CH2-cyano groups, or phenyl groups, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously form -(CH2) j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously =CR e R f Replaced by, In each of the above groups, R e These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, R f These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-8 membered heterocyclyl group, 3-10 membered heterocyclyl group, or 3-8 membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and the above C 1-6 One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7-12 membered bicyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3-20 membered heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6 membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8-10 membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. A heteroatom selected from nitrogen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-6 member monocyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 5-15 member tricyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 6-12 member heteroaryl group condensed cycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 6-12 member heteroaryl group condensed heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, If the ring atom is a sulfur atom, that sulfur atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above, If the ring atom is a phosphorus atom, that phosphorus atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above.

[0015] In one embodiment, TIFF2026530065000048.tif72163 A selection is made from the group consisting of the following, where X and R3 are the same as defined in any one of the paragraphs of this disclosure.

[0016] In one embodiment, TIFF2026530065000049.tif44125 Selected from among, R 13 X and R3 are defined as in any one of the provisions of this disclosure.

[0017] In one embodiment, TIFF2026530065000050.tif44123 Selected from among, of which X and R3 are the same as defined in any one of the paragraphs of this disclosure.

[0018] A first aspect of this disclosure further provides a compound represented by formula (A), or a stable deuterated derivative, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. TIFF2026530065000051.tif138157 (A) Of these, W1 is CH, C, or N, W2 is CH, C, or N, and W3 is CR. 13 , O, S, N or NH, and W4 is CR 13 It is O, S, N, or NH, and W5 is absent, or O or CR. 14 And, R1, R2, R3, R 42 , R 43 , R 4a R5, R6, R 13 , R 14 L1 is defined as in any one of the paragraphs of this disclosure.

[0019] A first aspect of this disclosure further provides a compound represented by formula (B), or a stable deuterated derivative, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. TIFF2026530065000052.tif129118 (B) Of those, W6 is CR 13 Or selected from N, R1, R2, R3, R 42 , R 43 , R 4a R5, R6, R 13 L1 is defined as in any one of the paragraphs of this disclosure.

[0020] A first aspect of this disclosure further provides compounds represented by formulas (A1), (A2), (A3), (A4), (A5), (A6), (B1), (B2), (B3), or (B4), or stable deuterated derivatives, stereoisomers thereof, or pharmaceutically acceptable salts, solvates, or prodrugs thereof. TIFF2026530065000053.tif255140 The definitions of each group are the same as those defined in any one of the paragraphs of this disclosure.

[0021] In one embodiment, in formulas (A1), (A2), (A3), (A4), (A5), (A6), (B1), (B2), (B3), or (B4), R 13 C is hydrogen, halogen, or substituted or unsubstituted C 1-6 It is an alkyl group, R 42 C is hydrogen, halogen, or substituted or unsubstituted C 1-6 It is an alkyl group, R 43 C is hydrogen, halogen, or substituted or unsubstituted C 1-6 It is an alkyl group, or R 42 and R 43 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Forming a cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, L1 is -N(R 00 )C(=O)-, -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, substituted or unsubstituted C 1-6 Alkyl alkyl groups, -substituted or unsubstituted C 1-6 Alkyl-O-,-substituted or unsubstituted C 2-6 Alkenyl-O-substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl groups, -L2-substituted or unsubstituted C 6-10 An aryl group, an -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or an -L2-substituted or unsubstituted 3 to 8-membered heterocyclyl group, L2 is -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -CR 09 =CR 10 -, -N(R 00 )C(=O)- or -N(R 00 )C(=S)-, R 00 is hydrogen or C 1-6 It is an alkyl group, R1 is hydrogen, deuterium, halogen, hydroxyl group, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C 2-6Alkenyl group, substituted or unsubstituted C 2-6 Alkynyl group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 4a is a substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 A cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, R5 is -NR 01 R 02 or -C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 And, R 01 , R 02 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Selected from alkynyl groups, or R 01 , R 02 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, or substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups. R 09 C is hydrogen, deuterium, halogen, or substituted or unsubstituted C 1-6 It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. R 10 C is hydrogen, deuterium, halogen, or substituted or unsubstituted C 1-6It is an alkyl group, and the above substitution means that it is substituted with one or more (e.g., 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. R6 is either substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, In each of the above groups, the above substitution means that each group is independently substituted with 1, 2, 3, 4, 5, or 6 groups selected from the S1 group, and each of the S1 group groups is independently deuterium, oxo (=O), thio (=S), and CR. e R f ,=NR e , halogen, cyano group, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Alkoxy group, C 3-20 Cycloalkyl group, 3-20 membered heterocyclyl group, C 6-14 Aryl group, 5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -OC 3-20 Cycloalkyl group, -O-3~20 member heterocyclyl group, -OC 6-14 Aryl group, -O-5 or 6-membered monocyclic heteroaryl group, -O-8 to 10-membered bicyclic heteroaryl group, -C≡CC 3-20 Cycloalkyl group, -C≡C-3~20 member heterocyclyl group, -C≡CC 6-14 Aryl group, -C≡C-5 or 6-membered monocyclic heteroaryl group, -C≡C-8 to 10-membered bicyclic heteroaryl group, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C≡CC 1-4 Alkyl-C 6-14Aryl group, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C≡CC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C 1-4 Alkyl-O-3~20 member heterocyclyl group, -C 1-4 Alkyl-C 6-14 Aryl group, -C 1-4 Alkyl-OC 6-14 Aryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-hydroxyl group, -OC 1-4 Alkyl-cyano group, -OC 1-4 Alkyl-C 1-6 alkyl group, -OC 1-4 Alkyl-C 1-6 Alkoxy group, -OC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -OC 1-4 Alkyl-O-3~20 member heterocyclyl group, -OC 1-4 Alkyl-C 6-14 Aryl group, -OC 1-4 Alkyl-OC 6-14Aryl group, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-20 Cycloalkyl group, -S(=O)2-3~20 member heterocyclyl group, -C(=O)OC 1-6 Alkyl alkyl group, -C(=O)OC 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-20 Cycloalkyl groups, -C(=O)-C 6-14 Aryl group, -NR a1 R b1 -C(=O)-NR a1 R b1 -C(=O)-NR d1 -C 1-4 Alkyl-R c1 , -OR c1 , -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-S(=O)2-3~20 member heterocyclyl group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 6-14 Aryl group, -C(=O)-5 or 6-membered monocyclic heteroaryl group, -C(=O)-8 to 10-membered bicyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-C 3-20Cycloalkyl groups, -C(=O)-C 1-6 Alkyl-3 to 20-membered heterocyclyl group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl group, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-NR a1 R b1 , -C 1-4 Alkyl-C(=O)-NR a1 R b1 -C≡CC(=O)-NR a1 R b1 -C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 , -C 1-4 Alkyl-OR c1 , -C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2,-C 1-4 Alkyl-NR d1 -C(=O)-R c1 , -C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-R c1 , -C 1-4 Alkyl-S(=O)2-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 , -NR d1 -C(=O)-R c1 , -NR d1 -C(=O)-C 1-4 Alkyl-R c1 , -NR d1 -C(=O)-NR a1 R b1 , -NR d1 -S(=O)2-Rc1 -S(=O)2-NR a1 R b1 , -NR d1 -S(=O)2-NR a1 R b1 and -P(=O)-(C 1-6 Selected from the group consisting of alkyl)2, of which the above C 1-6 Alkyl alkyl group, above C 1-6 Alkoxy group, above C 2-6 Alkenyl group, above C 2-6 Each alkynyl group is independently and optionally substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the above C 3-20 Cycloalkyl group, the above 3-20 membered heterocyclyl group, the above C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently and arbitrarily substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R a1 , R b1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-6 Monocyclic cycloalkyl group, -S(=O)2-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-S(=O)2-3~6 member monocyclic heterocyclyl group, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-6 It is a monocyclic cycloalkyl group or a -C(=O)-3 to 6-membered monocyclic heterocyclyl group, of which the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2 and -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, or Each R a1 and R b1These, together with the nitrogen atom linked to them, form a 3-20 membered heterocyclyl group, and each of these 3-20 membered heterocyclyl groups can independently and arbitrarily be a halogen, hydroxyl group, carboxyl group, nitro group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2 and -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each R d1 H and C are independent of each other. 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, each R c1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, or -C 1-4 It is an alkyl-8~10 membered bicyclic heteroaryl group, and the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2 and -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each S2 group group is independently deuterium, oxo (=O), thio (=S), and =CR. e R f ,=NR e , halogen, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-(C=O)-NHC1-6 Alkyl group, -(C=O)-N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -(C=O)C 1-6 Selected from the group consisting of alkyl groups and -SF5, In each of the above groups, -C 1-4 Alkyl- is unsubstituted, or -C 1-4 Alkyl - The 1, 2, 3, or 4 hydrogen atoms on the alkyl group are each independently a halogen, cyano group, hydroxyl group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Substituted with a group selected from alkyl groups, -CH2-hydroxy groups, -CH2-cyano groups, or phenyl groups, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously form -(CH2) j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously =CR e R f Replaced by, In each of the above groups, R e These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, R f These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-8 membered heterocyclyl group, 3-10 membered heterocyclyl group, or 3-8 membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and the above C 1-6One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7-12 membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3-20 membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; and one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6 membered monocyclic heteroaryl group The atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 8-10 membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-6 membered monocyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 5-15 membered tricyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. If the ring atom is a sulfur atom, that sulfur atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above, If the ring atom is a phosphorus atom, that phosphorus atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above.

[0022] In one embodiment, formula (B1) is TIFF2026530065000054.tif129118 The definitions of each group are the same as those in any one of the paragraphs of this disclosure.

[0023] A first aspect of this disclosure further provides a compound represented by formula (B5), or a stable deuterated derivative, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. TIFF2026530065000055.tif114140 (B5) Of those, W6 is CR 13 Or selected from N, R1, R2, R3, R 42 , R 43 , R 4a R5, R6, R 13 L1 is defined as in any one of the paragraphs of this disclosure.

[0024] A first aspect of this disclosure further provides a compound represented by formula (C1), or a stable deuterated derivative, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. TIFF2026530065000056.tif104118 (C1) Of these, the definitions of each unit are the same as those defined in any one of the paragraphs of this disclosure.

[0025] In one embodiment, in formula (C1), R 42 C is hydrogen, halogen, or substituted or unsubstituted C 1-6 It is an alkyl group, R 43 C is hydrogen, halogen, or substituted or unsubstituted C 1-6 It is an alkyl group, or R 42 and R 43 These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. 3-6 Forming a cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, L1 is -N(R 00 )C(=O)-O-, -C 1-4 Alkyl-N(R 00 )C(=O)-, -C(=O)N(R 00 )-C 1-4 Alkyl-, -C 1-4 Alkyl-N(R 00 )C(=S)-, - substitution or unsubstituted C 1-6 Alkyl-O- or -- substituted or unsubstituted C2-6 It is an alkenyl-O-, R 00 is hydrogen or C 1-6 It is an alkyl group, R1 is hydrogen, deuterium, halogen, hydroxyl group, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 It is a heteroalkyl group, R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group, substituted or unsubstituted C 2-6 Alkynyl group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, R 4a is a substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 3-6 A cycloalkyl group or a substituted or unsubstituted 3-8 membered heterocyclyl group, R5 is -NR 01 R 02 or -C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 And, R 01 , R 02 Each is independently hydrogen, substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 alkoxy group, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted C 2-6 Alkenyl group or substituted or unsubstituted C 2-6 Selected from alkynyl groups, or R 01, R 02 These, together with the nitrogen atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, or substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups. R6 is either substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C 3-6 Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C 6-10 An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8-10-membered bicyclic heteroaryl group, In each of the above groups, the above substitution means that each group is independently substituted with 1, 2, 3, 4, 5, or 6 groups selected from the S1 group, and each of the S1 group groups is independently deuterium, oxo (=O), thio (=S), and CR. e R f ,=NR e , halogen, cyano group, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, C 1-6 Alkoxy group, C 3-20 Cycloalkyl group, 3-20 membered heterocyclyl group, C 6-14 Aryl group, 5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -OC 3-20 Cycloalkyl group, -O-3~20 member heterocyclyl group, -OC 6-14 Aryl group, -O-5 or 6-membered monocyclic heteroaryl group, -O-8 to 10-membered bicyclic heteroaryl group, -C≡CC 3-20 Cycloalkyl group, -C≡C-3~20 member heterocyclyl group, -C≡CC 6-14 Aryl group, -C≡C-5 or 6-membered monocyclic heteroaryl group, -C≡C-8 to 10-membered bicyclic heteroaryl group, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C≡CC 1-4Alkyl-3 to 20-membered heterocyclyl group, -C≡CC 1-4 Alkyl-C 6-14 Aryl group, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C≡CC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-3 to 20-membered heterocyclyl group, -C 1-4 Alkyl-O-3~20 member heterocyclyl group, -C 1-4 Alkyl-C 6-14 Aryl group, -C 1-4 Alkyl-OC 6-14 Aryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-hydroxyl group, -OC 1-4 Alkyl-cyano group, -OC 1-4 Alkyl-C 1-6 alkyl group, -OC 1-4 Alkyl-C 1-6 Alkoxy group, -OC 1-4 Alkyl-C 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-OC 3-20 Cycloalkyl groups, -OC 1-4 Alkyl-3 to 20-membered heterocyclyl group, -OC 1-4 Alkyl-O-3~20 member heterocyclyl group, -OC 1-4 Alkyl-C6-14 Aryl group, -OC 1-4 Alkyl-OC 6-14 Aryl group, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -OC 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -OC 1-4 Alkyl-O-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-20 Cycloalkyl group, -S(=O)2-3~20 member heterocyclyl group, -C(=O)OC 1-6 Alkyl alkyl group, -C(=O)OC 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-20 Cycloalkyl groups, -C(=O)-C 6-14 Aryl group, -NR a1 R b1 -C(=O)-NR a1 R b1 -C(=O)-NR d1 -C 1-4 Alkyl-R c1 , -OR c1 , -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-S(=O)2-3~20 member heterocyclyl group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl groups, -C 1-4 Alkyl-C(=O)-C 6-14Aryl group, -C(=O)-5 or 6-membered monocyclic heteroaryl group, -C(=O)-8 to 10-membered bicyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl groups, -C(=O)-C 1-6 Alkyl-3 to 20-membered heterocyclyl group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl group, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl group, -C(=O)-C 1-6 Alkyl-8~10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-NR a1 R b1 , -C 1-4 Alkyl-C(=O)-NR a1 R b1 -C≡CC(=O)-NR a1 R b1 -C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 , -C 1-4 Alkyl-OR c1 , -C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2,-C 1-4 Alkyl-NR d1 -C(=O)-R c1 , -C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-R c1 , -C 1-4 Alkyl-S(=O)2-NR a1 R b1 , -C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 , -NR d1 -C(=O)-R c1 , -NR d1 -C(=O)-C 1-4 Alkyl-Rc1 , -NR d1 -C(=O)-NR a1 R b1 , -NR d1 -S(=O)2-R c1 -S(=O)2-NR a1 R b1 , -NR d1 -S(=O)2-NR a1 R b1 and -P(=O)-(C 1-6 Selected from the group consisting of alkyl)2, of which the above C 1-6 Alkyl alkyl group, above C 1-6 Alkoxy group, above C 2-6 Alkenyl group, above C 2-6 Each alkynyl group is independently and optionally substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the above C 3-20 Cycloalkyl group, the above 3-20 membered heterocyclyl group, the above C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently and arbitrarily substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R a1 , R b1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-hydroxyl group, -C 1-4 Alkyl-cyano group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-C 3-6Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, -C 1-4 Alkyl-8~10 membered bicyclic heteroaryl group, -S(=O)2-C 1-6 Alkyl group, -S(=O)2-C 3-6 Monocyclic cycloalkyl group, -S(=O)2-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-S(=O)2-3~6 member monocyclic heterocyclyl group, -C(=O)-C 1-6 Alkyl group, -C(=O)-C 3-6 It is a monocyclic cycloalkyl group or a -C(=O)-3 to 6-membered monocyclic heterocyclyl group, of which the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2 or -P(=O)-(C 1-6Substituted with one or two groups selected from the group consisting of alkyl)2, or Each R a1 and R b1 These, together with the nitrogen atom linked to them, form a 3-20 membered heterocyclyl group, and each of these 3-20 membered heterocyclyl groups can independently and arbitrarily be a halogen, hydroxyl group, carboxyl group, nitro group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2 and -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each R d1 H and C are independent of each other. 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, each R c1 H and C are independent of each other. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-deuterated C 1-6 Alkyl alkyl group, -C 1-4 Alkyl-C 1-6 Alkoxy group, -C 1-4 Alkyl-halogenated C 1-6 Alkoxy group, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy group, C 3-6 Monocyclic cycloalkyl group, -C1-4 Alkyl-C 3-6 Monocyclic cycloalkyl group, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C 1-4 Alkyl-3~6 member monocyclic heterocyclyl group, -C 1-4 Alkyl-O-3~6 member monocyclic heterocyclyl group, phenyl group, -C 1-4 Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10 membered bicyclic heteroaryl group, or -C 1-4 It is an alkyl-8~10 membered bicyclic heteroaryl group, and the above C 3-6 Monocyclic cycloalkyl groups, the above 3-6 member monocyclic heterocyclyl groups, the above phenyl groups, the above 5 or 6 member monocyclic heteroaryl groups, and the above 8-10 member bicyclic heteroaryl groups may optionally be halogens, hydroxyl groups, carboxyl groups, nitro groups, and C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2 and -P(=O)-(C 1-6 Substituted with one or two groups selected from the group consisting of alkyl)2, In each of the above groups, each S2 group group is independently deuterium, oxo (=O), thio (=S), and =CR. e R f ,=NR e , halogen, hydroxyl group, carboxyl group, nitro group, C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkoxy group, deuterated C1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2,-(C=O)-NHC 1-6 Alkyl group, -(C=O)-N(C 1-6 Alkyl)2,-C 1-4 Alkyl-P(=O)-(C 1-6 Alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -(C=O)C 1-6 Selected from the group consisting of alkyl groups and -SF5, In each of the above groups, -C 1-4 Alkyl- is unsubstituted, or -C 1-4 Alkyl - The 1, 2, 3, or 4 hydrogen atoms on the alkyl group are each independently a halogen, cyano group, hydroxyl group, or C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Substituted with a group selected from alkyl groups, -CH2-hydroxy groups, -CH2-cyano groups, or phenyl groups, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously form -(CH2) j - is substituted to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or C 1-4 Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously =CR e R f Replaced by, In each of the above groups, R e These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, R f These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-8 membered heterocyclyl group, 3-10 membered heterocyclyl group, or 3-8 membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and the above C 1-6 One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7-12 membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3-20 membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; and one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6 membered monocyclic heteroaryl group The atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 8-10 membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3-6 membered monocyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the above 5-15 membered tricyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. If the ring atom is a sulfur atom, that sulfur atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above, If the ring atom is a phosphorus atom, that phosphorus atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above.

[0026] In one embodiment, R 4a is -C 1-6 Alkyl-C 1-6 It is an alkoxy group.

[0027] In one embodiment, R4a is -C 1-3 Alkyl-C 1-3 It is an alkoxy group.

[0028] In one embodiment, R 4a It is -CH(CH3)-O-CH3.

[0029] In one embodiment, R 4a teeth TIFF2026530065000057.tif8755 That is the case.

[0030] In one embodiment, R5 is hydrogen, TIFF2026530065000058.tif218170TIFF2026530065000059.tif232170TIFF20265300650 00060.tif236170TIFF2026530065000061.tif243170TIFF2026530065000062.tif167170 They are selected from among them.

[0031] In one embodiment, R5 is TIFF2026530065000063.tif30131 They are selected from among them.

[0032] In one embodiment, R3 is hydrogen, C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl groups, deuterated C 1-6 Alkyl alkyl group or C 3-6 It is a cycloalkyl group.

[0033] In one embodiment, R3 is hydrogen, C 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group.

[0034] In one embodiment, R3 is hydrogen, C 1-3 Alkyl alkyl groups, C halogenated compounds 1-3ア Lukil group or deuterated C1-3 It is an alkyl group.

[0035] In one embodiment, R3 is an ethyl group, an isopropyl group, or a cyclopentyl group.

[0036] In one embodiment, R3 is a trifluoroethyl group.

[0037] In one embodiment, R 13 It is either hydrogen or fluorine.

[0038] In one embodiment, R 13 It is either a hydrogen atom or a methoxy group.

[0039] In one embodiment, R1 is hydrogen and R2 is hydrogen.

[0040] In one embodiment, R 42 R is a methyl group, 43 It is a methyl group.

[0041] In one embodiment, Y4 is O.

[0042] In one embodiment, Y5 is O.

[0043] In one embodiment, R 12 It is hydrogen.

[0044] In one embodiment, R5 is -NR 01 R 02 And R 01 , R 02 These, together with the nitrogen atoms they link to, form substituted or unsubstituted 3- to 8-membered monocyclic heterocycline groups.

[0045] In one embodiment, R5 is -C 2-4 Alkinyl-C 1-4 Alkyl-NR 01 R 02 And R 01 , R 02These, together with the nitrogen atoms they link to, form substituted or unsubstituted 3- to 8-membered monocyclic heterocycline groups.

[0046] One or more (e.g., 1, 2, 3, or 4) ring atoms of the above 3- to 8-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur, and the above substitution means that 1, 2, 3, 4, 5, or 6 hydrogen atoms on the above group are independently substituted with groups selected from the S1 group, and in the case where the ring atom is a sulfur atom, the sulfur atom may optionally be oxo and =NR. e Substituted by one or two groups selected from R e These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group.

[0047] In one embodiment, a 3- to 8-membered monocyclic heterocycline group is TIFF2026530065000064.tif49163 Selected from the above. Preferably, the 3-8 membered monocyclic heterocyclyl group is unsubstituted or substituted with one or two groups selected from the group consisting of a methyl group, -CH2OH, a cyano group, -C(=O)CH2OH, and -CH2NH2.

[0048] In one embodiment, R5 is TIFF2026530065000065.tif30145 They are selected from among them.

[0049] In one embodiment, Y1 is N and Y2 is CH.

[0050] In one embodiment, Y1 is CH and Y2 is N.

[0051] In one embodiment, Y1 is N + -O - Therefore, Y2 is CH.

[0052] In one embodiment, Y1 is CH and Y2 is N + -O - That is the case.

[0053] In one embodiment, X is TIFF2026530065000066.tif7452 For example, TIFF2026530065000067.tif64109 That is the case.

[0054] In one embodiment, X is TIFF2026530065000068.tif11361 For example, TIFF2026530065000069.tif86112 That is the case.

[0055] In one embodiment, L1 is TIFF2026530065000070.tif6449 That is the case.

[0056] In one embodiment, L1 is TIFF2026530065000071.tif7466 And among them, "*A" indicates the position connected to ring A.

[0057] In one embodiment, L1 is TIFF2026530065000072.tif31160 That's fine.

[0058] In one embodiment, L1 is TIFF2026530065000073.tif26153 And among them, "*A" indicates the position connected to ring A.

[0059] In one embodiment, L1 is TIFF2026530065000074.tif7556 That is the case.

[0060] In one embodiment, L1 is TIFF2026530065000075.tif7473 And among them, "*A" indicates the position connected to ring A.

[0061] In one embodiment, L1 is -L2- substituted or unsubstituted C 6-10 It is aryl-, and L2 is -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -C=C- or -N(R 00 )C(=S)-. In one embodiment, the above C 6-10 The aryl group is either a phenyl group or a naphthyl group.

[0062] In one embodiment, L1 is a -L2-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl-, and L2 is -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -C=C- or -N(R 00 )C(=S)-. In one embodiment, the above 5 or 6-membered monocyclic heteroaryl group is thiazole or oxazole.

[0063] In one embodiment, L1 is a -L2-substituted or unsubstituted 3- to 8-membered heterocyclyl-, and L2 is -O-, -C 1-4 alkyl-, -N(R 00 )-, -C(=O)-, -C=C- or -N(R 00 )C(=S)-. In one embodiment, the above 3- to 8-membered heterocyclyl group is TIFF2026530065000076.tif28157 A selection is made from these, where the wavy line indicates that the ring atom in question is at one bond position, and the other bond positions can be any position on the remaining ring atoms.

[0064] In one embodiment, L1 is TIFF2026530065000077.tif76163 They are selected from among them.

[0065] In one embodiment, L1 is TIFF2026530065000078.tif96163 Selected from these, "*A" indicates a position connected to ring A.

[0066] In one embodiment, L1 is TIFF2026530065000079.tif34159 They are selected from among them.

[0067] In one embodiment, L1 is TIFF2026530065000080.tif26140 Selected from these, "*A" indicates a position connected to ring A.

[0068] In one embodiment, R6 is a substituted or unsubstituted C 1-6 Alkyl alkyl group, substituted or unsubstituted C 1-6 Heteroalkyl groups, substituted or unsubstituted C 3-6 The group is a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclyl group, where the substitutions are as defined herein. In one embodiment, the above C 1-6 The alkyl group is an isopropyl group, methyl group, s-butyl group, isobutyl group, n-propyl group, ethyl group, pentyl group, neopentyl group, or t-pentyl group.

[0069] In one embodiment, the above C 1-6 heteroalkyl groups are TIFF2026530065000081.tif34140 That is the case.

[0070] In one embodiment, the above C 3-6 The cycloalkyl group is a cyclopropyl group.

[0071] In one embodiment, the 3-8 membered heterocyclyl group is an azetidinyl group, a thietanyl group, a tetrahydropyrrolyl group, a cyclopropane ring-condensed tetrahydrofuran ring group, a cyclopropane ring-condensed pyrrolidinyl group, or a cyclopropane ring-condensed tetrahydrothiophene ring group.

[0072] In one embodiment, the above substitution means that each of the above groups is independently substituted with 1, 2, 3, 4, 5, or 6 groups selected from group S1, and each of the groups in group S1 is independently deuterium, oxo (=O), =NR e , halogen, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, halogenated C 1-6 Alkyl alkyl group, C 3-6 Cycloalkyl groups, 3-8 membered heterocyclyl groups, 5 or 6 membered monocyclic heteroaryl groups, the above 8-10 membered bicyclic heteroaryl groups, -OC 3-6 Cycloalkyl group, phenyl group, -C 1-4 Alkyl-C 3-6 Cycloalkyl groups, -C 1-4 Alkylphenyl groups and -NR a1 R b1 Selected from the group consisting of the above C 1-6 Alkyl alkyl group, above C 1-6 Each alkoxy group is independently substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the above C 3-6 The cycloalkyl group, the 3-8 membered heterocyclyl group, the phenyl group, the 5 or 6 membered monocyclic heteroaryl group, and the 8-10 membered bicyclic heteroaryl group are each independently and optionally substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R a1 , R b1 Each is independently H or C 1-6 It is an alkyl group, In each of the above groups, each group of the S2 group is independently a halogen, C 1-6 Alkyl alkyl group, C 1-6 Alkoxy group, -NH2, -NHC 1-6 Alkyl alkyl group, -(C=O)C1-6 Selected from the group consisting of alkyl groups, -SF5 and -CH2-hydroxyl groups, In each of the above groups, R e These are H, halogen, and C, respectively, independently. 1-6 Alkyl alkyl groups, C halogenated compounds 1-6 Alkyl or deuterated C 1-6 It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8- to 10-membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. If the ring atom is a sulfur atom, that sulfur atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above, If the ring atom is a phosphorus atom, that phosphorus atom can be optionally oxo and =NR. e Substituted by one or two groups selected from R e The definition is the same as above.

[0073] In one embodiment, R6 is TIFF2026530065000082.tif57170 They are selected from among them.

[0074] In one embodiment, R6 is TIFF2026530065000083.tif105170 They are selected from among them.

[0075] In one embodiment, R 11 teeth TIFF2026530065000084.tif54138 They are selected from among them.

[0076] In one embodiment, R6 is a substituted or unsubstituted C 3-6 The cycloalkyl group is a cycloalkyl group, and the above substitutions are as defined in any one of the provisions.

[0077] In one embodiment, R6 is C 1-6 It is a cyclopropyl group substituted with an alkyl group. Preferably, R6 is a cyclopropyl group substituted with a methyl group. Preferably, R6 is a cyclopropyl group substituted with two methyl groups. For example, R6 is TIFF2026530065000085.tif39125 That is the case.

[0078] In one embodiment, in each of the above formulas, TIFF2026530065000086.tif5160 teeth TIFF2026530065000087.tif4958 In one embodiment, when Y4 is oxygen, TIFF2026530065000088.tif5156 That is the case.

[0079] In one embodiment, in each of the above formulas, TIFF2026530065000089.tif5756 teeth TIFF2026530065000090.tif5756 In one embodiment, when Y3 is C(=O)R6, TIFF2026530065000091.tif6976 That is the case.

[0080] In one embodiment, the above compound is selected from Table C.

[0081] [Table C] In one embodiment, the above compound is selected from Table B.

[0082] [Table B] TIFF2026530065000094.tif242170TIFF2026530065000095.tif255170TIFF2026530065000096.tif255168TIFF20265300650 00097.tif247170TIFF2026530065000098.tif255167TIFF2026530065000099.tif255167TIFF2026530065000100.tif110170 In one embodiment, the above compound is selected from Table A.

[0083] This disclosure further provides the following manufacturing methods, in which the compounds shown can be produced by synthesis methods well known to those skilled in the art, or by combining methods well known to those skilled in the art with the methods of this disclosure.

[0084] This disclosure provides a method for producing the following intermediate 1: TIFF2026530065000101.tif44163

[0085] This disclosure provides a method for producing the following intermediate 4-1: TIFF2026530065000102.tif74170

[0086] This disclosure provides a method for producing the following intermediate 10-1. TIFF2026530065000103.tif57163

[0087] This disclosure provides a method for producing the following intermediate 11. TIFF2026530065000104.tif200170

[0088] This disclosure provides a method for producing the following intermediate 15-2. TIFF2026530065000105.tif43170

[0089] This disclosure provides a method for producing the following intermediate 62-1. TIFF2026530065000106.tif67170 TIFF2026530065000107.tif43170 TIFF2026530065000108.tif71170 TIFF2026530065000109.tif48168 TIFF2026530065000110.tif50144

[0090] This disclosure provides a method for producing the following intermediate 62-p. TIFF2026530065000111.tif63170

[0091] This disclosure provides a method for producing the following intermediate 8-8. Synthesis route 1: TIFF2026530065000112.tif80170 Synthesis route 2: TIFF2026530065000113.tif47170 TIFF2026530065000114.tif42170 TIFF2026530065000115.tif70132.

[0092] Eventually, R pThese are well-known amino protecting groups in this field, such as formyl group, acyl groups such as alkanoyl groups (e.g., acetyl group, trichloroacetyl group, or trifluoroacetyl group), alkoxycarbonyl groups such as t-butoxycarbonyl group (Boc), arylmethoxycarbonyl groups such as benzyloxycarbonyl group (Cbz) and 9-fluorenylmethyloxycarbonyl group (Fmoc), arylmethyl groups such as benzyl group (Bn), trityl group (Tr), and 1,1-di-(4'-methoxyphenyl)methyl, and silyl groups such as trimethylsilyl group (TMS) and t-butyldimethylsilyl group (TBS).

[0093] R q These are well-known hydroxy protecting groups in this field, such as ether-based protecting groups (methyl ether (ROMe), t-butyl ether (ROtBu), benzyl ether (ROBn), p-methoxybenzyl ether (ROPMB), trityl ether (ROTr)), silyl ether-based protecting groups (trimethylsilyl group (TMS), triethylsilyl group (TES), triisopropylsilyl group (TIPS), t-butyldimethylsilyl group (TBS), t-butyldiphenylsilyl group (TBDPS), methoxymethyl ether (MOM), tetrahydropyranyl ether (THP), etc.), and ester-based protecting groups (acetyl group (Ac), benzoyl group (Bz), pivaloyl group (Piv), etc.).

[0094] In this disclosure, the compounds represented by formulas (I), (A), and (B) can be prepared by synthetic methods well known to those skilled in the art, or by a combination of such methods and the methods described herein. The solvents, temperatures, and other reaction conditions shown herein are all illustrative and can be modified according to methods well known in the art. The example compounds described herein can be synthesized according to the methods described in the examples using appropriate starting materials, depending on their specific structure, or they can be synthesized using methods similar to those described in the examples. The starting materials for synthesizing the example compounds of this disclosure can be prepared by well known synthetic methods or similar methods described in the literature, or commercially available materials can be used. The example compounds can be separated to obtain their stereoisomers, if necessary, using methods well known in the art, such as crystallization or chromatography.

[0095] To further explain, the compounds represented by formulas (B5-1) and (B5-2) in this disclosure can be synthesized by the following method, and the solvent, temperature and other reaction conditions in each step may be the same as or similar to those in the examples described below, or reaction conditions well known in the art may be used.

[0096] TIFF2026530065000116.tif255165 TIFF2026530065000117.tif113152.

[0097] In the manufacturing pathways of the compounds shown by formulas (B5-1) and (B5-2), in each formula, R pThese are well-known amino protecting groups in this field, such as formyl group, acyl groups such as alkanoyl groups (e.g., acetyl group, trichloroacetyl group, or trifluoroacetyl group), alkoxycarbonyl groups such as t-butoxycarbonyl group (Boc), arylmethoxycarbonyl groups such as benzyloxycarbonyl group (Cbz) and 9-fluorenylmethyloxycarbonyl group (Fmoc), arylmethyl groups such as benzyl group (Bn), trityl group (Tr), and 1,1-di-(4'-methoxyphenyl)methyl, and silyl groups such as trimethylsilyl group (TMS) and t-butyldimethylsilyl group (TBS).

[0098] R A , R B Each is independently a halogen atom (e.g., chlorine or bromine), a boric acid group (e.g., -B(OH)2), or a boric acid ester group (e.g., TIFF2026530065000118.tif8996 ) and of which, R A If R is selected from halogen atoms, B R is selected from boric acid group or boric acid ester group. B If R is selected from halogen atoms, A The group is selected from a boric acid group or a boric acid ester group.

[0099] W6, R3, R 42 , R 43 , R 4a The definitions of R5 and R6 are the same as those in any one of the paragraphs of this disclosure (for example, the definitions of the corresponding groups in formula I or formula B5).

[0100] The synthesis routes of the compounds of formula (B5-1) or formula (B5-2) described above are illustrative, and in a specific manufacturing process, a person skilled in the art can adjust the order of each step in the reaction route based on the prior art and the structure of the target compound.

[0101] A second aspect of this disclosure provides pharmaceutical compositions and pharmaceutically acceptable carriers comprising the compounds described in the first aspect, or stable deuterated derivatives thereof, or stereoisomers thereof, or pharmaceutically acceptable salts, solvates, or prodrugs thereof.

[0102] A third aspect of this disclosure provides the above compound as a medicament.

[0103] The term "pharmaceutically acceptable carrier" refers to any formulation or carrier medium that can deliver an effective amount of the active substance of the present invention, does not interfere with the biological activity of the active substance, and is free from toxicity and side effects to the host or subject. Typical carriers include water, oil, vegetables and minerals, creams, detergent substrates, ointment substrates, etc. These substrates include suspending agents, tackifiers, transdermal accelerators, etc. These formulations are well known to technicians in the fields of cosmetics or topical drugs.

[0104] In embodiments of the present invention, the pharmaceutical composition can be administered by any method, including oral administration, spray inhalation, rectal administration, nasal administration, cheek administration, topical administration, parenteral administration such as injection or infusion into the subcutaneous, intravenous, intramuscular, intraperitoneal, intrathecal, ventricular, sternal, and intracranial regions, or administration via an explanted reservoir. Of these, oral, intraperitoneal, or intravenous administration is preferred. Aqueous suspension formulations are usually used by mixing the active ingredient with a suitable emulsifier and suspension agent. Sweeteners, fragrances, or colorants may be further added to the oral formulation as needed. In the case of topical administration, particularly for the treatment of affected areas or organs where topical application is easily performed, such as the eyes, skin, or lower enteric nerve diseases, the compounds of the present invention may be manufactured in the form of different topical administration formulations depending on the affected area or organ. When administered topically to the eye, the compounds of the present invention may be manufactured in the form of a microparticle suspension or solution formulation, and the carrier used is an isotonic sterile physiological saline with a constant pH, which may or may not contain a preservative such as benzyl alkoxide chloride. For ophthalmic use, the compound may be manufactured in the form of an ointment such as petrolatum. For topical administration to the skin, the compound of the present invention may be manufactured in the form of a suitable ointment, lotion, or cream formulation in which the active ingredient is suspended or dissolved in one or more carriers. Carriers usable in ointment formulations include, but are not limited to, mineral oil, liquid petrolatum, white petrolatum, propylene glycol, polyethylene oxide, polypropylene oxide, emulsifying wax, and water. Carriers usable in lotions or creams include, but are not limited to, mineral oil, sorbitan monostearate, Tween 60, cetyl ester wax, hexadecenearyl alcohol, 2-octyldodecanol, benzyl alcohol, and water. The compound of the present invention can also be administered in the form of a sterile injection formulation including sterile injection water or oil suspension or sterile injection solution. Usable carriers and solvents include water, Ringer's solution, and isotonic sodium chloride solution. In addition, sterilized non-volatile oils, such as glycerides or diglycerides, can also be used as solvents or suspension media.

[0105] Another aspect of this disclosure provides the use of the compounds described in the first aspect, or their stable deuterated derivatives, or their stereoisomers, or their pharmaceutically acceptable salts, solvates, or prodrugs, or the pharmaceutical compositions described in the second aspect, in the manufacture of agents for the prevention and / or treatment of diseases or conditions related to RAS protein activity.

[0106] Another aspect of the present disclosure provides a method for preventing and / or treating a disease or condition related to RAS protein activity, the method comprising the steps of administering to a subject in need a therapeutically effective amount of a compound described in the first aspect of the present disclosure, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, or administering a therapeutically effective amount of a pharmaceutical composition described in the second aspect.

[0107] In this specification, in one embodiment, the disease or condition associated with the RAS protein activity is cancer, including, but not limited to, pancreatic cancer, colorectal cancer, non-small cell lung cancer, acute myeloid leukemia, multiple myeloma, thyroid adenocarcinoma, myelodysplastic syndrome, squamous cell lung cancer, esophageal cancer, ovarian cancer, uterine cancer, malignant melanoma, bladder cancer, or head and neck cancer.

[0108] In one embodiment, the cancer includes wild-type RAS and RAS mutations. The RAS includes HRAS, KRAS, and NRAS.

[0109] In one embodiment, the RAS mutation is a KRAS G12C, KRAS G12D, KRAS G12V, KRAS G12S, KRAS G13C, KRAS G13D, KRAS Q61L, KRAS Q61H, NRAS G12C, NRAS Q61K, NRAS Q61R mutation, or another RAS mutation.

[0110] In this specification, the above use or method further includes the administration of additional anticancer therapy. In some embodiments, the additional anticancer therapy is a HER2 inhibitor, EGFR inhibitor, secondary RAS inhibitor, SHP2 inhibitor, SOS1 inhibitor, RAF inhibitor, MEK inhibitor, ERK inhibitor, PI3K inhibitor, PTEN inhibitor, AKT inhibitor, mTORC1 inhibitor, BRAF inhibitor, PD-L1 inhibitor, PD-1 inhibitor, CDK4 / 6 inhibitor, or a combination thereof.

[0111] Another aspect of this disclosure provides a method for treating cancer in a subject who requires it, and the method is (a) Confirm that the above cancers are related to RAS protein activity; and (b) administering to the subject a therapeutically effective dose of a compound described in the first aspect of this disclosure, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, or a therapeutically effective dose of a pharmaceutical composition described in the second aspect.

[0112] In one embodiment, the above administration is performed by a route of administration selected from extra-gastrointestinal, intraperitoneal, percutaneous, intraperitoneal, intradermal, intracardiac, intraventricular, intracranial, intracerebrospinal, intraluminal, synovial, intrathecal, intramuscular, intravitreous, intravenous, intra-arterial, oral, buccal, sublingual, percutaneous, local, intratracheal, rectal, subcutaneous, and local administration.

[0113] Another aspect of the present disclosure provides a method for inhibiting intracellular RAS protein activity, the method comprising the steps of contacting the cells with a compound described in the first aspect of the present disclosure, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, or contacting the cells with a pharmaceutical composition described in the second aspect of the present disclosure. The cells may be in vivo or in vitro.

[0114] Another aspect of this disclosure provides the use of the compounds described in the first aspect, or their stable deuterated derivatives, or their stereoisomers, or their pharmaceutically acceptable salts, solvates, or prodrugs, or the pharmaceutical compositions described in the second aspect, in the manufacture of RAS protein activity inhibitors.

[0115] Definitions and Terms As used herein, the term “subject” refers to an animal, in particular a mammal; preferably a human.

[0116] As used herein, the terms “effective dose” or “therapeutic effective dose” refer to a sufficient amount of a drug or agent that is non-toxic but capable of achieving the desired effect. In embodiments of the present invention, the amount of drug administered when treating a patient according to the present invention depends on various factors, including the specific administration plan, the type and severity of the disease or symptom, and the individual characteristics of the subject or host being treated (e.g., body weight). However, depending on the specific circumstances, such as the specific drug employed, the route of administration, the disease or symptom being treated, and the subject or host being treated, the dose can usually be determined by methods well known in the art. Typically, doses used for treating adults range from 0.02 to 5000 mg / day, for example, about 1 to 1500 mg / day. The required dose can be expressed as a single dose, multiple doses administered simultaneously (or within a short period of time), or divided doses at appropriate intervals, for example, two, three, four or more divided doses per day. Those skilled in the art will understand that although the above dose ranges are given, the specific effective dose can be appropriately adjusted based on the patient's condition and the physician's diagnosis.

[0117] As used herein, the term “pharmaceutically acceptable salt” means a salt of the compound of the present invention that is pharmaceutically acceptable and has the pharmacological activity of the parent compound. Such salts include acid addition salts with inorganic acids such as nitric acid, phosphoric acid, and carbonic acid, or organic acids such as propionic acid, caproic acid, cyclopentanepropionic acid, glycolic acid, pyruvic acid, gluconic acid, stearic acid, and muconic acid; salts formed when an acidic proton present on the parent compound is substituted with a metal ion such as an alkali metal ion or an alkaline earth metal ion; or coordination compounds with an organic base such as ethanolamine. The pharmaceutically acceptable salts of the present invention can be synthesized from a parent compound containing an acid group or a base by conventional chemical methods. Generally, such salts are produced by reacting these compounds in the form of a free acid or base with a stoichiometrically appropriate base or acid in water, an organic solvent, or a mixture of both. Generally, non-aqueous media such as ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. In addition to the salt form, the compounds provided by the present invention also exist in prodrug form. The prodrugs of the compounds described herein are readily converted to the compounds of the present invention by chemical transformation under physiological conditions. The prodrugs may be converted to the compounds of the present invention by chemical or biochemical methods in an in vivo environment.

[0118] As used herein, the term "solvate" refers to a substance formed by the combination of a compound of the present invention with a pharmaceutically acceptable solvent. Pharmaceutically acceptable solvents include acetic acid, among others. Solvates include stoichiometric solvates and non-stoichiometric solvates. Some compounds of the present invention may exist in non-solvated or solvated forms. Generally, the solvated form corresponds to the non-solvated form, and both are included within the scope of the present invention.

[0119] As used herein, the term “stereoisomer” includes conformational isomers and configurational isomers, of which configurational isomers mainly include cis-trans isomers and optical isomers. Since the compounds of the present invention can exist in the form of stereoisomers, this includes, but is not limited to, cis-trans isomers, tautomers, enantiomers, diastereomers, atropisomers, and all other possible stereoisomer forms. Furthermore, the compounds of the present invention may exist in the form of any combination or mixture of the above stereoisomers, such as meso compounds, racemates, or equimolar mixtures of atropisomers. For example, they may be a single enantiomer, a single diastereomer, or a mixture thereof, or a single atropisomer or a mixture thereof. If the compounds of the present invention contain an olefin double bond, unless otherwise specified, this includes cis isomers and trans isomers, and any combination thereof. Atropisomers in the present invention are stereoisomers having axial chirality or planar chirality, resulting from restricted intramolecular rotation. Furthermore, when used as a pharmaceutical, stereoisomers with excellent activity are preferred. The compounds of the present invention have optical isomers derived from asymmetric carbons, etc., and if necessary, a single isomer can be obtained by separation using methods well known to those skilled in the art, such as crystallization or chiral chromatography.

[0120] When used in this specification, the above = CR e R f Substitution is when an atom in a molecule is replaced by a double bond via a CR bond. e R f This means that it is bonded to the carbon atom (C) inside. In other words, the atoms of the molecule are TIFF2026530065000119.tif2950 Replaced by: When used herein, above =NR e Substitution is when an atom in the molecule is replaced by an NR via a double bond. e This means that it is bonded to the nitrogen atom (N) inside. In other words, the atoms of the molecule are TIFF2026530065000120.tif2841 It is replaced by. As used herein, oxo means that the atom of the molecule is bonded to an oxygen atom (O) via a double bond. In other words, the atom of the molecule is TIFF2026530065000121.tif3433 It is replaced by . As used herein, thio means that the atom of the molecule is bonded to the sulfur atom (S) via a double bond. In other words, the atom of the molecule is TIFF2026530065000122.tif2827 It is substituted with. As used herein, when a group such as an alkyl group is located in the middle of a structural formula, it means that the group is a subunit. For example, alkyl group means alkylene group, etc.

[0121] As used herein, the term “alkyl group” refers to a linear or branched saturated aliphatic hydrocarbon group. 1-6 The term "alkyl group" refers to linear and branched alkyl groups having 1, 2, 3, 4, 5, or 6 carbon atoms. More preferably C 1-4 It is an alkyl group. More preferably C 1-3 These are alkyl groups. Specific examples include, but are not limited to, methyl group, ethyl group, n-propyl group, isopropyl group, n-butyl group, isobutyl group, t-butyl group, sec-butyl group, n-pentyl group, 1,1-dimethylpropyl group, 1,2-dimethylpropyl group, 2,2-dimethylpropyl group, 1-ethylpropyl group, 2-methylbutyl group, 3-methylbutyl group, n-hexyl group, 1-ethyl-2-methylpropyl group, 1,1,2-trimethylpropyl group, 1,1-dimethylbutyl group, 1,2-dimethylbutyl group, 2,2-dimethylbutyl group, 1,3-dimethylbutyl group, 2-ethylbutyl group, 2-methylpentyl group, 3-methylpentyl group, 4-methylpentyl group, 2,3-dimethylbutyl group, and various branched isomers thereof. The alkyl groups described in this invention may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0122] As used herein, the term “heteroalkyl group” refers to an alkyl group in which at least one carbon atom is substituted with a heteroatom (e.g., an O, N, or S atom), the definition of an alkyl group being as given above. 1-6 The term "heteroalkyl group" refers to linear and branched heteroalkyl groups having 1, 2, 3, 4, 5, or 6 carbon atoms. Preferably C 1-4 It is a heteroalkyl group. More preferably C 1-3 It is a heteroalkyl group. The heteroatom may be located in the middle or at the end of the group. The heteroalkyl group may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred. Exemplary heteroalkyl groups include alkoxy groups and alkylthio groups.

[0123] As used herein, the term “alkoxy group” refers to a group having an -O-alkyl group structure, where the definition of alkyl group is as defined above. 1-6 The term "alkoxy group" refers to an alkoxy group having 1 to 6 carbon atoms. Preferably C 1-4 It is an alkoxy group. More preferably C 1-3 The group is an alkoxy group. Specific examples include, but are not limited to, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, t-butoxy, isobutoxy, and n-pentyloxy groups. The alkoxy group may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0124] As used herein, the term “alkylthio group” refers to a group having an -S-alkyl group structure, where the definition of alkyl is as defined above. 1-6 The term "alkylthio group" refers to an alkylthio group having 1 to 6 carbon atoms. Preferably C 1-4 It is an alkylthio group. More preferably C 1-3The alkylthio group is an alkylthio group. The alkylthio group may be substituted or unsubstituted, and if substituted, one or more substituents as described in this application are preferred.

[0125] As used herein, the term “alkenyl group” means an alkyl group as defined above, having one or more carbon-carbon double bonds at any position in the chain, and “C 2-6 The term "alkenyl group" refers to an alkenyl group having 2 to 6 carbon atoms and at least one (e.g., 1 to 2) carbon-carbon double bonds. Preferably C 2-4 The alkenyl group is an alkenyl group having 2 to 4 carbon atoms and 1 to 2 carbon-carbon double bonds. Specific examples include, but are not limited to, vinyl groups, 1-propenyl groups, 2-propenyl groups, 1-, 2-, or 3-butenyl groups, pentenyl groups, hexenyl groups, and butadienyl groups. The above alkenyl groups may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0126] As used herein, the term “alkynyl group” means an alkyl group as defined above, having one or more carbon-carbon triple bonds at any position in the chain, and “C 2-6 The term "alkynyl group" refers to an alkynyl group having 2 to 6 carbon atoms and at least one (e.g., 1 to 2) carbon-carbon triple bonds. Preferably C 2-4 The alkynyl group is an alkynyl group having 2 to 4 carbon atoms and 1 to 2 carbon-carbon triple bonds. Specific examples include, but are not limited to, ethynyl, 1-propynyl, 2-propynyl, and 1-, 2-, or 3-butynyl groups. The alkynyl group may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0127] As used herein, the term "halogen" refers to fluorine, chlorine, bromine, or iodine.

[0128] As used herein, the term "halogenation" refers to fluoro, chloro, bromo, or iodine.

[0129] As used herein, the term “halogenated alkyl group” refers to an alkyl group in which one or more (e.g., 1, 2, 3, 4, or 5) hydrogen atoms are substituted with halogen atoms, the definition of alkyl group being as above. 1-6 The term "alkyl group" refers to a halogenated alkyl group having 1 to 6 carbon atoms. Preferably a halogenated alkyl group. 1-4 It is an alkyl group. More preferably a halogenated C 1-3 It is an alkyl group. Specific examples include, but are not limited to, monochloromethyl, dichloromethyl, trichloromethyl, monochloroethyl, 1,2-dichloroethyl, trichloroethyl, monobromoethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, and trifluoroethyl groups. The above halogenated alkyl group may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0130] As used herein, the term "halogenated alkoxy group" refers to an alkoxy group in which one or more (e.g., 1, 2, 3, 4, or 5) hydrogen atoms are substituted with halogen atoms, the definition of an alkoxy group being as defined above. 1-6 The term "alkoxy group" refers to a halogenated alkoxy group having 1 to 6 carbon atoms. Preferably, halogenated "C 1-4 It is an alkoxy group. More preferably a halogenated C 1-3 The group is an alkoxy group. Specific examples include, but are not limited to, trifluoromethoxy, trifluoroethoxy, monofluoromethoxy, monofluoroethoxy, difluoromethoxy, and difluoroethoxy groups. The above halogenated alkoxy group may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0131] As used herein, the term “deuterated” refers to the substitution of one or more hydrogen atoms (e.g., 1, 2, 3, 4, or 5) in a group with deuterium atoms.

[0132] As used herein, the term “deuterated alkyl group” refers to an alkyl group in which one or more (e.g., 1, 2, 3, 4, or 5) hydrogen atoms are substituted with deuterium atoms, the definition of an alkyl group being as given above. 1-6 The term "alkyl group" refers to a deuterated alkyl group having 1 to 6 carbon atoms. Preferably a deuterated C 1-4 It is an alkyl group. More preferably, deuterated C 1-3 It is an alkyl group. Specific examples include, but are not limited to, monoduteromethyl, diduteromethyl, triduteromethyl, monoduteroethyl, 1,2-diduteroethyl, and triduteroethyl groups. The above deuterated alkyl group may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0133] As used herein, the term “deuterated alkoxy group” refers to an alkoxy group in which one or more (e.g., 1, 2, 3, 4, or 5) hydrogen atoms are substituted with deuterium atoms, the definition of an alkoxy group being as above. 1-6 The term "alkoxy group" refers to a deuterated alkoxy group having 1 to 6 carbon atoms. More preferably, a deuterated C 1-4 It is an alkoxy group. More preferably, deuterated C 1-3 The group is an alkoxy group. Specific examples include, but are not limited to, a trideuteromethoxy group, a trideuteroethoxy group, a monodeuteromethoxy group, a monodeuteroethoxy group, a dideuteromethoxy group, and a dideuteroethoxy group. The above deuterated alkoxy group may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0134] As used herein, "cycloalkyl group" and "cycloalkyl ring" are interchangeable and refer to saturated or partially unsaturated monocyclic or polycyclic cyclic hydrocarbon groups. The ring-constituting carbon atoms of the above cycloalkyl group may be optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, etc.) oxo groups to form a cycloketone structure. "3-20 membered cycloalkyl group" or "C 3-20 The term "cycloalkyl group" refers to a cycloalkyl group having 3 to 20 ring-constituting carbon atoms. This can include monocyclic cycloalkyl groups, spirocycloalkyl groups, condensed cycloalkyl groups, and crosslinked cycloalkyl groups. Preferably C 3-12 Cycloalkyl groups (e.g., C 3-8 Cycloalkyl groups, C 3-6 Cycloalkyl groups, C 3-8 (e.g., monocyclic cycloalkyl groups), C 5-20 Spirocycloalkyl group, C 5-20 Condensed cycloalkyl groups, C 5-20 Examples include cross-linked cycloalkyl groups.

[0135] When used herein, "C 3-6 The term "cycloalkyl group" refers to a cycloalkyl group having 3 to 6 ring-forming carbon atoms. It can be monocyclic (specific examples include cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl groups) or bicyclic (specific examples include, but are not limited to, cyclopropanocyclopropane, cyclopropanocyclobutane, and cyclopropanocyclopentane).

[0136] When used herein, "C 3-8 The terms "monocyclic cycloalkyl group" and "3-8 membered monocyclic cycloalkyl group" refer to saturated or partially unsaturated monocyclic cyclic hydrocarbon groups having 3 to 8 ring-constituting carbon atoms. Preferably C 3-6 Monocyclic cycloalkyl groups (i.e., 3-6 member monocyclic cycloalkyl groups) or C 4-6It is a monocyclic cycloalkyl group (i.e., a 4- to 6-membered monocyclic cycloalkyl group). More preferably, it is a C3, C4, C5, or C6 monocyclic cycloalkyl group. Specific examples of monocyclic cycloalkyl groups include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl groups.

[0137] As used herein, the terms “spirocycloalkyl group” and “spiroalkyl ring” refer to a saturated or partially unsaturated polycyclic cyclic hydrocarbon group formed by two or more monocyclic rings sharing one carbon atom (called a spiro atom). Depending on the number of spiro atoms shared between the rings, they are classified as monospirocycloalkyl groups, bisspirocycloalkyl groups, or polyspirocycloalkyl groups. “5-20 membered spirocycloalkyl groups” or “C 5-20 The term "spirocycloalkyl group" refers to a spirocycloalkyl group having 5 to 20 ring-constituting carbon atoms. Preferably, it has 6 to 14 members (i.e., C 6-14 ) is a spirocycloalkyl group. More preferably a 6-14 member monospirocycloalkyl group. More preferably a 7-11 member (i.e., C 7-11 ) is a spirocycloalkyl group. More preferably, it is a 7- to 11-membered monospirocycloalkyl group. More preferably, it is a 7-, 8-, 9-, 10-, or 11-membered monospirocycloalkyl group. Specific examples of spirocycloalkyl groups are TIFF2026530065000123.tif41146 This includes, but is not limited to, the following. These spirocycloalkyl groups can be bonded to the remainder of the molecule via any ring atom.

[0138] As used herein, the terms "condensed cycloalkyl group" and "condensed cycloalkyl ring" refer to saturated or partially unsaturated polycyclic cyclic hydrocarbon groups formed by two or more monorings sharing a pair of adjacent carbon atoms. They can be classified into bicyclic, tricyclic, tetracyclic, or polycyclic condensed cycloalkyl groups depending on the number of rings they comprise. "5-20 membered condensed cycloalkyl groups" or "C 5-20The term "condensed cycloalkyl group" refers to a condensed cycloalkyl group having 5 to 20 ring-constituting carbon atoms. Preferably, it has 6 to 14 members (i.e., C 6-14 ) is a condensed cycloalkyl group. More preferably, it is a 6-14 member bicyclic condensed cycloalkyl group. More preferably, it is a 7-10 member (i.e., C 7-10 ) is a condensed cycloalkyl group. More preferably, it is a 7-10 member bicyclic condensed cycloalkyl group. More preferably, it is an 8-member, 9-member, or 10-member bicyclic condensed cycloalkyl group. Specific examples of condensed cycloalkyl groups are TIFF2026530065000124.tif34162 This includes, but is not limited to, the following. These condensed cycloalkyl groups can be bonded to the remainder of the molecule via any ring atom.

[0139] As used herein, the terms "crosslinked cycloalkyl group" and "crosslinked alkyl ring" refer to saturated or partially unsaturated polycyclic hydrocarbon groups formed by two or more monocyclic rings sharing two carbon atoms that are not directly bonded to each other. Depending on the number of rings formed, crosslinked cycloalkyl groups can be classified as bicyclic, tricyclic, tetracyclic, or polycyclic. "5-20 membered crosslinked cycloalkyl groups" and "C 5-20 The term "crosslinked cycloalkyl group" refers to a crosslinked cycloalkyl group having 5 to 20 ring-constituting carbon atoms. Preferably, it has 6 to 14 members (i.e., C 6-14 ) A crosslinked cycloalkyl group. More preferably 7 to 10 members (i.e., C 7-10 ) These are cross-linked cycloalkyl groups. Specific examples of cross-linked cycloalkyl groups TIFF2026530065000125.tif22152 This includes, but is not limited to, the following. These crosslinked cycloalkyl groups can be bonded to the remainder of the molecule via any ring atom.

[0140] Each of the above types of cycloalkyl groups may be substituted or unsubstituted, and if substituted, one or more substituents as described in this application are preferred.

[0141] As used herein, the terms “heterocyclyl group” and “heterocyclic group” are interchangeable and refer to saturated or partially unsaturated monocyclic or polycyclic cyclic hydrocarbon groups, of which one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, etc.) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur, but do not contain the -OO-, -OS-, or -SS- ring portions, and the remaining ring atoms are carbon. If the ring atom is a nitrogen atom, it may be substituted or unsubstituted (i.e., N or NR, where R is hydrogen or another substituent already defined herein), and / or the nitrogen atom may form a quaternary ammonium salt. If the heteroatom is a sulfur atom, the sulfur atom may be optionally oxidized (e.g., S(=O) m ',m' is an integer between 0 and 2). If the heteroatom is a phosphorus atom, the phosphorus atom may be oxidized of any choice (e.g., P(=O)). m (where '', m'' is an integer 0, 1, or 2). Examples include monocyclic heterocyclyl groups, spiroheterocyclyl groups, condensed heterocyclyl groups, and bridged heterocyclyl groups. The ring-forming carbon atoms of the above heterocyclyl groups may be optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) oxo groups to form a cycloketone, cyclolactone, or cyclolactam structure. The term "3-20 membered heterocyclyl group" refers to a heterocyclyl group having 3 to 20 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. The above 3-20 membered heterocyclyl groups are preferably 3-10 membered heterocyclyl groups, 3-12 membered monocyclic heterocyclyl groups (e.g., 3-8 membered monocyclic heterocyclyl groups), 5-20 membered spiroheterocyclyl groups, 5-20 membered condensed heterocyclyl groups, 5-20 membered bridged heterocyclyl groups, etc.

[0142] The term "3-10 membered heterocyclyl group" refers to a saturated or partially unsaturated cyclic hydrocarbon group having 3 to 10 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. The term "3-8 membered heterocyclyl group" refers to a saturated or partially unsaturated cyclic hydrocarbon group having 3 to 8 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. The above heterocyclyl groups may be monocyclic (specific examples are, for example, described in the definition of 3-8 membered monocyclic heterocyclyl groups) or bicyclic (specific examples include, but are not limited to, cyclopropane ring-condensed pyrrolidinyl groups and cyclopropane ring-condensed tetrahydrofuran ring groups).

[0143] As used herein, the terms “3-8 membered monocyclic heterocyclyl group,” “3-8 membered monocyclic heterocyclyl group,” and “3-8 membered monocyclic heterocyclyl group” refer to saturated or partially unsaturated monocyclic cyclic hydrocarbon groups having 3 to 8 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. Preferably, a 3-6 membered monocyclic heterocyclyl group having 3 to 6 ring atoms, of which one or more (e.g., 1 or 2) ring atoms are heteroatoms. More preferably, a 4-6 membered monocyclic heterocyclyl group having 4 to 6 ring atoms, of which one or more (e.g., 1 or 2) ring atoms are heteroatoms. More preferably, a 5 or 6 membered monocyclic heterocyclyl group having 5 or 6 ring atoms, of which one or more (e.g., 1 or 2) ring atoms are heteroatoms. Specific examples of monocyclic heterocyclyl groups include aziridine, oxirane, azetidine, azetidine-2-one, oxetanyl group, oxetanyl-2-one, oxazolidine, pyrrolidine-2-one, pyrrolidine-2,5-dione, 1,3-dioxolane, dihydrofuran-2(3H)-one, dihydrofuran-2,5-dione, piperidine-2-one, piperidine-2,6-dione, tetrahydro-2H-pyran-2-one, imidazolidine, tetrahydrofuran, tetrahydrothiophene, tetrahydropyrrole, 1,3-dioxolane-2-one, oxazolidine-2-one, imidazolidine-2-one, piperidine, piperazine, piperazine-2-one, morpholine, morpho Phosphate-3-one, morpholine-2-one, thiomorpholine-3-one 1,1-dioxide, thiomorpholine-, thiomorpholine-1,1-dioxide, tetrahydropyran, 1,2-dihydroazeteto, 1,2-dihydrooxetetto, 2,5-dihydro-1H-pyrrole, 2,5-dihydrofuran, 2,3-dihydrofuran, 2,3-dihydro-1H-pyrrole, 3,4-dihydro-2H-pyran, 1,2,3,4-tetrahydropyridine, 3,6-dihydro-2H-pyran, 1,2,3,6-tetrahydropyridine, 1,3-oxadinane, hexahydropyrimidine, 1,4-dioxane, tetrahydropyrimidine-2(1H)-one, 1,4-dioxane-2-one, 5,6-dihydro-2H-pyran-2-one, 5,6-dihydropyrimidine-4(3H)-one, 3,4-dihydropyridine-2(1H)-one, 5,6-dihydropyridine-2(1H)-one, 5,6-dihydropyrimidine-4(1H)-one, pyrimidine-4(3H)-one, pyrimidine-4(1H)-one, 4,5-dihydro-1H-imidazole, 2,3-dihydro-1H-imidazole, 2,3-dihydroxazole, 1,3-dioxol, 2,3-dihydrothiophene, 2,5-dihydrothiophene, 3,4-dihydro-2H-1,4-oxazine, 3,4-dihydro-2H-1,4-thiaidine 1,1-dioxide, 1,2,3,4-tetrahydropyrazine, 1,3-dihydro- This includes, but is not limited to, 2H-pyrrole-2-one, 1,5-dihydro-2H-pyrrole-2-one, 1H-pyrrole-2,5-dione, furan-2(3H)-one, furan-2(5H)-one, 1,3-dioxol-2-one, oxazole-2(3H)-one, 1,3-dihydro-2H-imidazole-2-one, furan-2,5-dione, 3,6-dihydropyridine-2(1H)-one, pyridine-2,6-(1H,3H)-dione, 5,6-dihydro-2H-pyran-2-one, 3,6-dihydro-2H-pyran-2-one, 3,4-dihydro-2H-1,3-oxazine, 3,6-dihydro-2H-1,3-oxazine, 1,2,3,4-tetrahydropyrimidine, etc.

[0144] As used herein, the term "nitrogen-containing 3- to 8-membered heterocyclyl group" refers to a saturated or partially unsaturated cyclic hydrocarbon group having 3 to 8 ring atoms, of which one ring atom is a nitrogen atom and the other (e.g., 1, 2, 3, 4, or 5) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. The term "nitrogen-containing 4- to 8-membered heterocyclyl group" refers to a saturated or partially unsaturated cyclic hydrocarbon group having 4 to 8 ring atoms, of which one ring atom is a nitrogen atom and the other (e.g., 1, 2, 3, 4, or 5) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. The heterocyclyl groups described herein may be monocyclic or bicyclic. Specific examples include, but are not limited to, azilidinyl, azetidine, pyrrolidinyl (i.e., tetrahydropyrrole), piperidinyl (i.e., hexahydropyridine), morpholinyl, piperazinyl, and oxazole groups.

[0145] Two adjacent ring atoms (including CC and NC) on the ring of the monocyclic heterocyclil group described above may optionally condense with a cycloalkyl group, heterocyclil group, aryl group, or heteroaryl group, such as a monocyclic cycloalkyl ring, monocyclic heterocyclil ring, monocyclic aryl ring, or 5- or 6-membered monocyclic heteroaryl group ring, as defined in the present invention, to form a fused polycycle. In a monocyclic heterocyclil group that forms a fused ring with another ring, the two ring atoms that link are preferably CC.

[0146] As used herein, the terms “spiroheterocyclyl group” and “spiroheterocyclic group” refer to a polycyclic heterocyclyl group formed by two or more saturated or partially unsaturated monorings sharing one carbon atom (called a spiro atom), where one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, etc.) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur, and the other ring atoms are carbon. Each monoring may contain one or more double bonds, but none of the rings have a fully conjugated π-electron system. Depending on the number of spiro atoms shared between the rings, they are classified as monospiroheterocyclyl groups, bisspiroheterocyclyl groups, or polyspiroheterocyclyl groups. The term "5-20 membered spiroheterocyclyl group" refers to a spiroheterocyclyl group having 5 to 20 ring atoms, of which one or more (e.g., 1, 2, 3, 4, 5, etc.) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. Preferably, it is a 6-14 membered spiroheterocyclyl group having 6 to 14 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5, etc.) ring atoms are heteroatoms. More preferably, it is a 7-11 membered spiroheterocyclyl group having 7 to 11 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5, etc.) ring atoms are heteroatoms. Most preferably, it is a 7-, 8-, or 10-membered monospiroheterocyclyl group. Specific examples of spiroheterocyclyl groups TIFF2026530065000126.tif112170 This includes, but is not limited to, the following:

[0147] These spiroheterocyclyl groups can be bonded to the rest of the molecule via any suitable ring atom.

[0148] As used herein, the terms “condensed heterocyclyl group” and “condensed heterocyclic ring” refer to a polycyclic heterocyclyl group formed by two or more saturated or partially unsaturated monorings sharing an adjacent pair of ring atoms, where one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, etc.) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur, and the other ring atoms are carbon. Each monoring may contain one or more double bonds, but none of the rings have a fully conjugated π-electron system. The shared adjacent ring atom pair can be CC or NC. Depending on the number of rings, condensed heterocyclyl groups can be classified as bicyclic, tricyclic, tetracyclic, or polycyclic. The term "5-20 membered condensed heterocyclyl group" refers to a condensed heterocyclyl group having 5 to 20 ring atoms, of which one or more (e.g., 1, 2, 3, 4, 5, etc.) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. Preferably, it is a 6-14 membered condensed heterocyclyl group having 6 to 14 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5, etc.) ring atoms are heteroatoms. More preferably, it is a 6-10 membered condensed heterocyclyl group having 6 to 10 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5, etc.) ring atoms are heteroatoms. More preferably, it is an 8-10 membered condensed heterocyclyl group having 8 to 10 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5, etc.) ring atoms are heteroatoms. Most preferably, it is an 8-membered, 9-membered, or 10-membered bicyclic condensed heterocyclyl group. Specific examples of condensed heterocyclyl groups are TIFF2026530065000127.tif49170 This includes, but is not limited to, the following:

[0149] These condensed heterocyclyl groups can be bonded to the rest of the molecule via any suitable ring atom.

[0150] As used herein, the terms "bridged heterocyclyl group" and "bridged heterocyclic ring" refer to a polycyclic heterocyclyl group formed by two or more saturated or partially unsaturated monorings sharing two non-directly linked ring atoms, where one or more (e.g., 1, 2, 3, 4, 5, 6, 7, 8, etc.) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur, and the other ring atoms are carbon. Depending on the number of rings formed, they can be classified as bicyclic, tricyclic, tetracyclic, or polycyclic bridged cycloalkyl groups. The term "5-20 membered bridged heterocyclyl group" refers to a bridged heterocyclyl group having 5-20 ring atoms, where one or more (e.g., 1, 2, 3, 4, 5, etc.) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. Each monoring may contain one or more double bonds, but none of the rings have a fully conjugated π-electron system. Preferably, it is a 6-14 membered bridged heterocyclyl group. More preferably, it is a 7-10 membered crosslinked heterocyclyl group. Specific examples of crosslinked heterocyclyl groups are: TIFF2026530065000128.tif41170 This includes, but is not limited to, the following:

[0151] These cross-linked heterocyclyl groups can be bonded to the rest of the molecule via any suitable ring atom.

[0152] Each type of heterocyclyl group described in the present invention may be optionally substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0153] The term "5-15 membered tricyclic heterocyclyl group" refers to a tricyclic heterocyclyl group having 5 to 15 ring atoms, of which three rings may be linked in one or more ways selected from spirobonding, condensation, and bridging. Specific examples include, but are not limited to, a configuration in which the first monoring is a 6-membered monocyclic heteroring, the second monoring is a 6-membered monocyclic heteroring, the third monoring is a 3- to 6-membered monocyclic heteroring, and the first and second monorings are condensed and the third and second monorings are spirobonded.

[0154] The term "7-12 membered bicyclic heterocyclyl group" refers to a bicyclic heterocyclyl group having 7 to 12 ring atoms, of which two rings may be linked in one manner selected from spirobonding, condensation bonding, and bridging bonding. Specific examples can be selected from the above examples of spiroheterocyclyl groups, condensation heterocyclyl groups, and bridging heterocyclyl groups.

[0155] As used herein, “aryl group,” “aryl ring,” and “aromatic ring” are interchangeable and refer to all-carbon monocyclic, all-carbon uncondensed polycyclic (where rings are covalently linked and not condensed) or all-carbon condensed polycyclic (i.e., rings sharing adjacent pairs of carbon atoms) groups. In these groups, at least one ring is aromatic, i.e., has a conjugated π-electron system. 6-14 The term "aryl group" refers to an aryl group having 6 to 14 ring atoms. Preferably C 6-10 It is an aryl group. (See above C) 6-14 Aryl groups include monocyclic aryl groups, non-condensed polycyclic aryl groups, and aromatic condensed polycyclic groups. Examples of monocyclic aryl groups include the phenyl group, while examples of non-condensed polycyclic aryl groups include the biphenyl group.

[0156] In the present invention, C 6-14When the aryl group is an aromatic fused polycyclic group, the aromatic fused polycyclic group may be a polycyclic group formed by the fusion of one or more monocyclic aryl rings, and non-limiting examples include naphthyl groups and anthryl groups.

[0157] In some embodiments of the present invention, C 6-14 When the aryl group is an aromatic condensed polycyclic group, the aromatic condensed polycyclic group may be a polycyclic group formed by the condensation of one or more monocyclic aryl rings (e.g., phenyl groups) with non-aromatic rings, and the ring bonded to the parent structure is either an aromatic or non-aromatic ring. The non-aromatic ring includes, but is not limited to, a 3-6 membered monocyclic heterocyclyl ring (preferably a 5 or 6 membered monocyclic heterocyclyl ring, in which the ring constituent carbon atoms of the monocyclic heterocyclyl ring are substituted with 1 or 2 oxo groups to form a cyclolactam or cyclolactone structure) and a 3-6 membered monocyclic cycloalkyl group (preferably a 5 or 6 membered monocyclic cycloalkyl group, in which the ring constituent carbon atoms of the monocyclic cycloalkyl group are substituted with 1 or 2 oxo groups to form a cycloketone structure). The polycyclic group formed by the condensation of one or more monocyclic aryl rings with non-aromatic rings can be bonded to other groups or the parent structure via a nitrogen atom or a carbon atom, and the ring bonded to the parent structure is either a monocyclic aryl ring or a non-aromatic ring.

[0158] Each aryl group described in the present invention may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0159] As used herein, “heteroaryl group,” “heteroaryl ring,” and “heteroaromatic ring” are interchangeable and refer to a monocyclic or fused polycyclic group (i.e., sharing pairs of adjacent ring atoms, where the shared pairs of adjacent ring atoms may be CC or NC) in which the ring atom is substituted with at least one heteroatom (e.g., 1, 2, 3, 4, 5, 6, 7, 8, etc.) independently selected from phosphorus, nitrogen, oxygen, or sulfur. The heteroaryl group has 6, 10, or 14 shared π electrons, and at least one ring in the group is aromatic. If the ring atom is a nitrogen atom, it may be substituted or unsubstituted (i.e., N or NR, where R is hydrogen or another substituent already defined herein), and / or the nitrogen atom may form a quaternary ammonium salt. If the heteroatom is a sulfur atom, the sulfur atom may be optionally oxidized (e.g., S(=O) m ',m' is an integer between 0 and 2). If the heteroatom is a phosphorus atom, the phosphorus atom may be oxidized of any choice (e.g., P(=O)). m '', m'' is an integer 0, 1, or 2). The term "5-14 membered heteroaryl group" refers to a heteroaryl group having 5 to 14 ring atoms, of which one or more (e.g., 1, 2, 3, 4, 5, etc.) ring atoms are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. Preferably, it is a 5-10 membered heteroaryl group having 5 to 10 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5, etc.) ring atoms are heteroatoms. The above 5-14 membered heteroaryl groups may be monocyclic heteroaryl groups, fused bicyclic heteroaryl groups, fused tricyclic heteroaryl groups, etc.

[0160] As used herein, the term “5- or 6-membered monocyclic heteroaryl group” refers to a monocyclic heteroaryl group having five or six ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5) are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. Specific examples of monocyclic heteroaryl groups include, but are not limited to, thiophene, furan, thiazole, isothiazole, imidazole, oxazole, pyrrole, pyrazole, triazole, 1,2,3-triazole, 1,2,4-triazole, 1,2,5-triazole, 1,3,4-triazole, tetrazole, isoxazole, oxadiazole, 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,3,4-oxadiazole, thiadiazole, pyridine, pyridazine, pyrimidine, and pyrazine.

[0161] As used herein, the term "8-10 membered bicyclic heteroaryl group" refers to a fused bicyclic heteroaryl group having 8 to 10 ring atoms, of which one or more (e.g., 1, 2, 3, 4, or 5) are heteroatoms selected from phosphorus, nitrogen, oxygen, or sulfur. The fused bicyclic heteroaryl group may be a bicyclic group (preferably a 9 or 10 membered bicyclic heteroaryl group) formed by the condensation of a monocyclic aryl ring (e.g., a phenyl group) with a monocyclic heteroaryl group (preferably a 5 or 6 membered monocyclic heteroaryl group), or a bicyclic group formed by the condensation of a monocyclic heteroaryl group (preferably a 5 or 6 membered monocyclic heteroaryl group) with a monocyclic heteroaryl group (preferably a 5 or 6 membered monocyclic heteroaryl group).

[0162] Any two ring atoms (including CC, NC, and NN) optionally linked on the ring of the monocyclic heteroaryl group may condense with a cycloalkyl group, heterocyclyl group, aryl group, or heteroaryl group, such as a monocyclic cycloalkyl ring, monocyclic heterocyclyl ring, monocyclic aryl ring, or 5- or 6-membered monocyclic heteroaryl group ring, as defined in the present invention, to form a fused polycycle. The two ring atoms linked on the ring of the monocyclic heteroaryl group that form a fused ring with another ring are preferably CC, and are not limited to TIFF2026530065000129.tif62170 Includes.

[0163] In the above TIFF2026530065000130.tif3296 The ring atoms represented by this symbol are linked to other parts of the molecule.

[0164] Non-restrictive examples of 8-10 membered bicyclic heteroaryl groups include benzo[d]isoxazole, 1H-indole, isoindole, 1H-benzo[d]imidazole, benzo[d]isothiazole, 1H-benzo[d][1,2,3]triazole, benzo[d]xazole, benzo[d]thiazole, indazole, benzofuran, benzo[b]thiophene, quinoline, isoquinoline, quinazoline, quinoxaline, sinnoline, pyrido[3,2-d]pyrimidine, pyrido[2,3-d]pyrimidine, pyrido[3,4-d]pyrimidine, pyrido[4,3-d]pyrimidine, 1,8-naphthiridine, 1,7-naphthiridine, 1,6-naphthiridine, 1,5-naphthiridine, pyrazolo[1,5-a]pyrimidine, imidazolo[1,2-b]pyridazine, etc.

[0165] Specific examples of bicyclic heteroaryl groups TIFF2026530065000131.tif55170 This includes, but is not limited to, the following groups. These groups can be bonded to the remainder of the molecule via any suitable ring atom. The ring bonded to the parent structure may be a monocyclic heteroaryl ring or a benzene ring.

[0166] In some embodiments of the present invention, the condensed bicyclic heteroaryl group or condensed tricyclic heteroaryl group may be a polycyclic group formed by the condensation of a monocyclic heteroaryl group (preferably a 5- or 6-membered monocyclic heteroaryl group) with one or more non-aromatic rings, wherein the ring bonded to the parent structure is a monocyclic heteroaryl group or a non-aromatic ring. The non-aromatic ring includes, but is not limited to, a 3- to 6-membered monocyclic heterocyclil ring (preferably a 5- or 6-membered monocyclic heterocyclil ring, in which the ring constituent carbon atoms of the monocyclic heterocyclil ring are substituted with 1-2 oxo groups to form a cyclolactam or cyclolactone structure), a 3- to 6-membered monocyclic cycloalkyl group (preferably a 5- or 6-membered monocyclic cycloalkyl group, in which the ring constituent carbon atoms of the monocyclic cycloalkyl group are substituted with 1 or 2 oxo groups to form a cycloketone structure), and the like. The polycyclic group formed by the condensation of the above monocyclic heteroaryl group with one or more non-aromatic rings can be bonded to other groups or the parent structure via a nitrogen atom or a carbon atom, and the ring bonded to the parent structure is either a monocyclic heteroaryl group or a non-aromatic ring.

[0167] The above 6-12 member heteroaryl group condensed cycloalkyl groups are formed by the condensation of a monocyclic heteroaryl group with a cycloalkyl group, and the ring bonded to the parent structure may be a monocyclic heteroaryl group or a cycloalkyl group. For example, a 5-membered monocyclic heteroaryl group may be formed by the condensation of a 3, 4, 5, 6, or 7-membered cycloalkyl group, or a 6-membered monocyclic heteroaryl group may be formed by the condensation of a 3, 4, 5, or 6-membered cycloalkyl group.

[0168] The above 6-12 member heteroaryl group condensed heterocyclyl groups are formed by the condensation of a monocyclic heteroaryl group with a heterocyclyl group, and the ring that bonds to the parent structure may be a monocyclic heteroaryl group or a heterocyclyl group. For example, a 5-membered monocyclic heteroaryl group may be formed by the condensation of a 3, 4, 5, 6, or 7-membered heterocyclyl group, or a 6-membered monocyclic heteroaryl group may be formed by the condensation of a 3, 4, 5, or 6-membered heterocyclyl group.

[0169] Each heteroaryl group described in the present invention may be substituted or unsubstituted, and if substituted, one or more substituents described in this application are preferred.

[0170] As used herein, the term "hydroxyl group" refers to -OH.

[0171] As used herein, the term "cyano group" refers to -CN.

[0172] As used herein, the term "nitro group" refers to -NO2.

[0173] As used herein, the term "benzyl group" refers to -CH2-phenyl.

[0174] As used herein, the term "oxo group" refers to =O.

[0175] As used herein, the term "carboxyl group" refers to -C(=O)OH.

[0176] As used herein, the term "acetyl group" refers to -COCH3.

[0177] Abbreviation: Cbz: Benzyloxycarbonyl group (Carbamoylbenzyl), TBDPS: t-butyldiphenylsilyl (tert-butyl(methoxy)diphenylsilyl) NCO is an isocyanate group, and (Bpin)2 is bis(pinacolate)diborone.

[0178] The alkyl groups, heteroalkyl groups, alkoxy groups, alkynyl groups, alkenyl groups, cycloalkyl groups, heterocyclyl groups, aryl groups, and heteroaryl groups described above may be substituted or unsubstituted. If substituted, one or more substituents described in this application are preferred.

[0179] As used herein, the term substitution means that any one or more hydrogen atoms on a particular atom are substituted with a substituent, and may include deuterium and hydrogen variants, provided that the valence state of the particular atom is normal and the substituted compound is stable. When the substituent is an oxo group (i.e., =O), it means that two hydrogen atoms are substituted. The terms "optionally substituted" or "optionally substituted" mean that substitution is optional and optional, and unless otherwise specified, the type and number of substituents may be arbitrary on the basis of chemical feasibility.

[0180] TIFF2026530065000132.tif3139 The symbol indicates the position of the chemical bond.

[0181] TIFF2026530065000133.tif3949 The symbol indicates the presence or absence of a double bond at any position within the ring, encompassing diverse situations such as saturated ring systems, unsaturated non-aromatic ring systems containing double bonds, and aromatic ring systems.

[0182] In this disclosure, TIFF2026530065000134.tif35124 This indicates the absolute arrangement of a single solid center. Unless otherwise specified, TIFF2026530065000135.tif3945 Insofar as it is structurally permissible, TIFF2026530065000136.tif36125 This includes cases where any of the following states may exist.

[0183] Ring TIFF2026530065000137.tif5158 If a nucleotide appears and its linkage position is unknown, then, as long as the valence is acceptable, the linkage site is TIFF2026530065000138.tif5158 This indicates that it is located at any atom in the monoring in which it exists.

[0184] If any variable (e.g., R) appears one or more times in the composition or structure of a compound, the definition in each case is independent. Therefore, for example, if a group is substituted with 0 to 2 Rs, the group may be optionally substituted with up to 2 Rs, and in each case, there is an independent choice for R. Otherwise, combinations of substituents and / or their variants are permitted only if such combinations produce a stable compound.

[0185] In any embodiment, any or all hydrogen atoms present in the compound, or hydrogen atoms in a specific group or site within the compound, may be substituted with deuterium or tritium. One to a maximum number of hydrogen atoms present in the compound may be substituted with deuterium. One to a maximum number of hydrogen atoms present in any group in the compound represented by the general formula or in a specific compound may be substituted with deuterium. For example, if a group is described as an ethyl group, the ethyl group may be C2H5 or C2H5 in which x (1 to 5) hydrogen atoms are substituted with deuterium, for example, C2D x H 5-x It is possible. When a group is described as a deuterated ethyl group, that deuterated ethyl group is a C2H5 with x (1 to 5) hydrogens substituted with deuterium, for example, C2D x H 5-x This is possible. The stable deuterated derivatives described in the present invention preferably refer to stable deuterium isotope derivatives obtained by substituting any deuterated hydrogen atom in each formula with one to a maximum number of deuterium atoms (e.g., 1-2, 1-3, 1-4, 1-5, 1-6, 1-7, etc.).

[0186] Unless otherwise stated, the structures described herein also mean compounds that differ only in the presence of one or more isotope-rich atoms. Exemplary isotopes that can be incorporated into the compounds of the present invention include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, sulfur, fluorine, chlorine, and iodine, for example, 2 H, 3H, 11 C, 13 C, 14 C, 13 N, 15 N, 15 O, 17 O, 18 O, 32 P, 33 P, 35 S, 18 F, 36 Cl, 123 I and 125 I is an isotope-labeled compound (for example) 3 H and 14 Compounds that can be labeled with C may be used to measure the compound or substrate tissue distribution. Tritiation (i.e., 3 H) and carbon-14 (i.e., 14 C) Isotopes are usable because they are easy to produce and detect. Furthermore, deuterium (i.e., 2 Substitution with relatively heavy isotopes such as H) can provide certain therapeutic benefits by improving metabolic stability (e.g., extending the half-life in the body or reducing the required dose). In some embodiments, one or more hydrogen atoms are 2 H or 3 Substituted with H, or one or more carbon atoms 13 C or 14 It is substituted with carbon-rich carbon atoms. 15 O, 13 N, 11 C and 18 Positron-emitting isotopes such as 14F may be used in positron emission tomography (PET) studies to investigate substrate receptor occupancy. The preparation of isotope-labeled compounds is well known to those skilled in the art. For example, isotope-labeled compounds can generally be prepared by replacing non-isotopically labeled reagents with isotope-labeled reagents, following procedures similar to those disclosed with respect to the compounds of the present invention described herein. [Brief explanation of the drawing]

[0187] [Figure 1] Figure 1 shows the molecular three-dimensional structure of intermediate 11-e-1 obtained by X-ray single-crystal diffraction. [Figure 2]Figure 2 shows the molecular three-dimensional structure of intermediate 51-7A obtained by X-ray single-crystal diffraction. [Figure 3] Figure 3 is a molecular three-dimensional structure diagram of intermediate 118-12 obtained by X-ray single-crystal diffraction. [Modes for carrying out the invention]

[0188] The compounds of the present invention can be produced by various synthesis methods well known to those skilled in the art, including the specific embodiments listed below, embodiments formed in combination with other chemical synthesis methods, and equivalent substitutional forms well known to those skilled in the art. Preferred embodiments include, but are not limited to, the examples of the present invention.

[0189] The present invention will be described in detail below with reference to examples, but this does not constitute any adverse limitation on the invention. Although this specification has already described the present invention in detail and disclosed specific examples, it will be clear to those skilled in the art that various changes and improvements can be made to specific embodiments of the present invention without departing from the spirit and scope of the invention. Unless otherwise specified in the examples, the examples were carried out under normal conditions or conditions recommended by the manufacturer. Unless otherwise specified, the reagents or equipment used are all commercially available, ordinary products.

[0190] The structure of a compound is determined by methods such as nuclear magnetic resonance (NMR) or mass spectrometry (MS).

[0191] NMR measurements were performed using a Bruker Avance NEO 400 or Bruker Avance NEO 500 nuclear magnetic resonance spectrometer. Chemical shifts (δ) were expressed in parts per million (ppm), and the measurement solvents were as shown in each example. Tetramethylsilane (TMS) was used as the internal standard.

[0192] MS measurements were performed using an Agilent 1100 liquid chromatograph.

[0193] High-performance liquid chromatography (HPLC) analysis was performed using a Waters 2695 high-performance liquid chromatograph.

[0194] A Waters 2767 high-performance liquid chromatograph was used for high-performance liquid preparative chromatography.

[0195] Chiral HPLC analysis was performed using either a Waters 2695 high-performance liquid chromatograph or a Waters Investigator SFC system.

[0196] Chiral preparative chromatography was performed using a Gilson GX-281 chromatograph or a Waters SFC-80 chromatograph.

[0197] For thin-layer chromatography, Qingdao GF254 or Yantai Huanghai HSGF254 silica gel plates were used. The silica gel plates used for thin-layer chromatography (TLC) were specified to be 0.15 mm to 0.2 mm thick. The plates used for product separation and purification by thin-layer chromatography were specified to be 0.4 mm to 0.5 mm thick.

[0198] Column chromatography generally uses the ISCO CombiFlash NextGen 300 column chromatography system, employing Agela Flash Column Silica-Cs series silica gel columns.

[0199] Unless otherwise specified, the following conditions shall be used for the preparative HPLC used in the following examples.

[0200] Preparative HPLC (Ammonium Bicarbonate Method 1): Column type: Waters XBridge C18, 19×250mm, 5um; Mobile phase system: A: 5 mmol / L ammonium bicarbonate aqueous solution, B: Acetonitrile for preparative separation; Flow rate: 15 mL / min; B% = 20%~100%; Column temperature: Room temperature.

[0201] Preparative HPLC (Ammonium Bicarbonate Method 2): Chromatography column: Welch Xtimate C18, 21.2 × 150 mm, 5 μm; Mobile phase A: 5 mmol / L ammonium bicarbonate aqueous solution; Mobile phase B: Acetonitrile; Flow rate: 15 mL / min; Column temperature: Room temperature.

[0202] Preparative HPLC (Formic Acid Method 1): Column type: Waters XBridge C18, 19×250mm, 5um; Mobile phase system: A: 0.1% formic acid aqueous solution, B: Acetonitrile for preparative separation; Flow rate: 15 mL / min, B% = 20%~100%, Column temperature: Room temperature.

[0203] Preparative HPLC (Formic Acid Method 2): Chromatography column Welch Xtimate C18, 21.2 × 150 mm, 5 μm; Mobile phase A: 0.1% formic acid aqueous solution; Mobile phase B: Acetonitrile; Flow rate: 15 mL / min; Column temperature: Room temperature.

[0204] Preparative HPLC (trifluoroacetic acid method): Chromatography column: Waters XBridge C18, 190×250mm, 5um; Mobile phase: A: 0.1% trifluoroacetic acid aqueous solution, B: Acetonitrile for preparative separation; Flow rate: 15 mL / min, B% = 20%~100%, Column temperature: Room temperature.

[0205] Preparative HPLC (hydrochloric acid method): Chromatography column: Waters XBridge C18, 190×250mm, 5um; Mobile phase system: A: 0.1% hydrochloric acid aqueous solution, B: Acetonitrile for preparative separation; Flow rate: 15 mL / min, B% = 20%~100%, Column temperature: Room temperature.

[0206] Preparative HPLC (aqueous ammonia method) chromatography column: Waters Xbridge C18, 19×150 mm, 5 μm; mobile phase A: 0.1% aqueous ammonia solution; mobile phase B: acetonitrile; flow rate: 15 mL / min; column temperature: room temperature.

[0207] 3min LCMS conditions: A: water (0.05% TFA) B: ACN (0.05% TFA) Elution gradient: 5%~95% B in 3min Flow rate: 1.7 mL / min Column type: SunFire C18, 4.6×50 mm, 3.5 μm Column temperature: 40℃.

[0208] Analytical HPLC conditions: A: water (0.05% TFA) B: ACN (0.05% TFA) Elution gradient: 10%~95% B in 15 min Flow rate: 1 mL / min Column type: SunFire C18, 4.6 × 150 mm, 3.5 μm Column temperature: 40 °C.

[0209] Instrument parameters of a single-crystal X-ray diffractometer: Light source: Cu target X-ray: Cu-Ka (=1.54178 Å) Detector: CMOS surface detector Resolution: 0.86 Å Current / Voltage: 50kV, 1.2mA; Exposure Time: 5s Distance from surface detector to sample: 40 mm; Test temperature: 170°K

[0210] Manufacturing Example 1: Synthesis of Intermediate 1 TIFF2026530065000139.tif37134 Step 1: Compound 1a (10 g, 46.279 mmol) was weighed and dissolved in tetrahydrofuran (100 mL). Bis(pinacolate)diboron (17.63 g, 69.419 mmol), 1,5-cyclooctadiene iridium chloride dimer (0.93 g, 1.388 mmol), and 4,4'-di-t-butyl-2,2'-bipyridine (1.86 g, 6.942 mmol) were added, and the mixture was reacted at 80°C for 15 hours under nitrogen gas protection. The mixture was filtered through diatomaceous earth and concentrated under reduced pressure to obtain the crude product, compound 1b, which was used directly in the next reaction. ES-API[M+H + ]=260.0.

[0211] Step 2: Compound 1b, the crude product obtained in the reaction of the previous step, is dissolved in acetonitrile (100 mL), hydrogen peroxide solution (1308.25 mg, 11.543 mmol) is added dropwise under an ice bath, the reaction is allowed to proceed at room temperature for 3 hours, saturated sodium sulfite solution (20 mL) is added, the reaction is quenched, the mixture is concentrated under reduced pressure, extracted with dichloromethane (25 mL x 3), the organic phase is washed with water (20 mL), washed with saturated brine (20 mL), dried over anhydrous sodium sulfate, concentrated under reduced pressure to obtain the crude product, purified by flash silica gel column (petroleum ether / ethyl acetate = 1 / 1) to obtain intermediate 1 (7000 mg, 30.162 mmol, yield 87.10%), which is a yellow solid and is ES-API[M+H + The values ​​were 232.1 and 234.1.

[0212] Manufacturing Example 2: Synthesis of Intermediate 4-1 TIFF2026530065000140.tif64140 Step 1: Compound 4a (60 g, 181.609 mmol) was dissolved in DMF (200 mL), sodium bicarbonate (45.77 g, 544.827 mmol) was added, and iodomethane (33.918 mL, 544.827 mmol) was added dropwise under nitrogen gas protection in an ice bath. The mixture was reacted overnight at room temperature. Water (200 mL) was added, the mixture was extracted with ethyl acetate (200 mL x 3), washed with water (200 mL), washed with saturated saline (200 mL x 3), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the crude product, compound 4b (65 g, 188.729 mmol, yield 103.92%), which was an oily liquid. ES-API [M-156+H] + = 189.1.

[0213] Step 2: The crude compound 4b (65 g, 188.729 mmol) was dissolved in dichloromethane (200 mL), and trifluoroacetic acid (200 mL) was added dropwise under nitrogen gas protection in an ice bath. The mixture was reacted overnight at room temperature and concentrated under reduced pressure to obtain the crude compound 4c, which was a colorless, transparent oily liquid. This was used directly in the next reaction: ES-API[M+H] + = 145.1.

[0214] Step 3: Compound 4d (50 g, 136.896 mmol) was dissolved in tetrahydrofuran (300 mL) and water (75 mL), lithium hydroxide monohydrate (9.38 g, 223.415 mmol) was added, and the mixture was reacted at room temperature for 4 hours. The pH was adjusted to 3 with 1N HCl, extracted with ethyl acetate (200 mL x 3), washed with water (200 mL x 3), washed with saturated saline solution (200 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain compound 4e (48 g, 136.670 mmol, yield 99.83%), which was a colorless, transparent oily liquid. [ES-API M-56+H] + =295.0.

[0215] Step 4: Dissolve compound 4c from Step 2 in anhydrous dichloromethane (200 mL), add NMM (100 g, 996 mmol) dropwise under nitrogen gas protection in an ice bath, then sequentially add compound 4e (35 g, 99.655 mmol), EDCI (38.07 g, 199.311 mmol), and HOBt (4.04 g, 29.897 mmol), react at room temperature for 4 hours, then sequentially add water (200 mL) and 1N Washed with HCl (80 mL) and saturated saline (200 mL), dried over anhydrous sodium sulfate, concentrated under reduced pressure to form a slurry (petroleum ether / ethyl acetate = 8 / 1) to obtain compound intermediate 4-1 (33 g, 69.129 mmol). The mother liquor was further purified by flash silica gel column to obtain compound intermediate 4-1 (4 g, 8.34 mmol), for a total of intermediate 4-1 (37 g, 77.5 mmol, yield 78.7%). White solid [ES-API M-56+H] + The result was 477.1.

[0216] Manufacturing Example 3: Synthesis of Intermediate 11 TIFF2026530065000141.tif135170 Step 1: Intermediate 1 (500 mg, 2.154 mmol) was dissolved in N,N-dimethylformamide (15 mL), and benzyl bromide (737 mg, 4.308 mmol) and potassium carbonate (893 mg, 6.462 mmol) were added to the solution. After the addition was complete, the reaction was carried out at 80°C for 17 hours with stirring. After the reaction was complete, water (30 mL) was added to the reaction mixture, and it was further extracted with ethyl acetate (20 mL x 2). The organic phase was separated, washed with saturated brine (40 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated to obtain the crude product. The crude product was purified by flash silica gel column (methanol / dichloromethane: 0%~2%) to obtain compound intermediate 4 (600 mg, 1.862 mmol, yield 86.44%), which was a white solid. ES-API: [M + H] + =322.1, 324.1.

[0217] Step 2: To a tetrahydrofuran (20 mL) solution of intermediate 4 (3 g, 9.311 mmol) protected with nitrogen gas at 0°C, isopropylmagnesium chloride-lithium chloride complex (10.027 mL, 13.035 mmol, 1.3 M tetrahydrofuran solution) was gradually added dropwise, and the mixture was stirred at 0°C for 0.5 hours. Then, at -10°C, the above solution was added dropwise to a tetrahydrofuran (20 mL) solution of 3,3-dimethyltetrahydropyranyl-2,6-dione (1.59 g, 11.173 mmol), and the mixture was stirred at 0°C for 2 hours. The pH of the solution was adjusted to 4-5 by adding 4 M hydrochloric acid / dioxane (4 mL) dropwise, and the reaction was quenched. The reaction mixture was extracted with ethyl acetate (20 mL x 3), dried over anhydrous sodium sulfate, filtered, concentrated, and then purified by silica gel column chromatography (petroleum ether / ethyl acetate = 1 / 1) to obtain compound 11-a (2.25 g, 5.837 mmol, yield 62.69%). ES-API: [M+H] + = 386.2.

[0218] Step 3: To a solution of compound 11-a (1000 mg, 2.594 mmol) in ethanol (20 mL), (4-bromophenyl)hydrazine (970.36 mg, 5.188 mmol) and a 4M hydrochloric acid-1,4-dioxane solution (3.891 mL) were added, and the reaction mixture was stirred at 90°C for 36 hours. The mixture was concentrated, the pH was further adjusted to neutral with an aqueous sodium bicarbonate solution, diluted with water, extracted with ethyl acetate (20 mL x 3), dried over anhydrous sodium sulfate, filtered, concentrated, and then purified by silica gel column (petroleum ether / ethyl acetate = 1 / 2) to obtain compound 11-b (1.15 g, 1.974 mmol, yield 76.09%). ES-API: [M+H] + = 582.2, 584.2.

[0219] Step 4: Compound 11-b (1.15 g, 1.974 mmol) was dissolved in trifluoroacetic acid (10 mL). The mixture was heated to 65°C, stirred for 2 hours, concentrated under reduced pressure, diluted with ethyl acetate, the pH of the residue was adjusted to 7-8 with saturated ammonium bicarbonate, and then extracted with ethyl acetate (20 mL x 3). The combined organic layer was dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated under reduced pressure, and further purified by silica gel column chromatography (petroleum ether / ethyl acetate = 1 / 2) to obtain compound 11-c (780 mg, 1.379 mmol, yield 69.87%). ES-API: [M+H] + = 565.2, 567.2.

[0220] Step 5: Compound 11-c (780 mg, 1.379 mmol) was dissolved in dried N,N-dimethylformamide (5 mL), and cesium carbonate (1347.83 mg, 4.137 mmol) and iodoethane (1075.41 mg, 6.895 mmol) were added sequentially. The mixture was stirred at room temperature under nitrogen gas protection and reacted for 2 hours. Extraction was performed with ethyl acetate (20 mL x 3). The organic layers were combined and washed sequentially with water (60 mL) and saturated brine (60 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. Further purification was performed by silica gel column chromatography (petroleum ether / ethyl acetate = 1 / 2) to obtain compound 11-d (750 mg, 1.264 mmol, yield 91.61%). ES-API: [M+H] + = 593.2, 595.2.

[0221] Step 6: Compound 11-d (750 mg, 1.264 mmol) was dissolved in dried tetrahydrofuran (10 mL), cooled to 0°C in an ice bath, and lithium aluminum hydride (3.159 mL, 3.159 mmol, 1 M tetrahydrofuran solution) was gradually added dropwise under nitrogen gas protection. After addition, the mixture was stirred at 0°C for 1 hour. After detecting completion of the reaction by LC-MS, water (0.12 mL), aqueous sodium hydroxide solution (0.12 mL, 15%), and water (0.36 mL) were added sequentially to quench the reaction mixture. The suspension was stirred at room temperature for 30 minutes, then filtered through diatomaceous earth and washed with ethyl acetate (100 mL). The mother liquor was dried over anhydrous sodium sulfate, filtered, concentrated, and purified by flash silica gel column (ethyl acetate / petroleum ether = 20%~60%) to obtain two intermediate compounds. The structure of one of the intermediate compounds is: 3-((R a The result was )-2-(5-(benzyloxy)-2-((1S)-1-methoxyethyl)pyridine-3-yl)-5-bromo-1-ethylindole-3-yl)-2,2-dimethylpropyl-1-ol (11-e-1, 300 mg, 0.544 mmol, yield 43.05%). 11-e-1: Rt = 1.847 min (3 min LC-MS). 1H NMR (400 MHz, DMSO) δ 8.48 (d, J = 2.8 Hz, 1H), 7.84 (d, J = 2.0 Hz, 1H), 7.45-7.30 (m, 7H), 7.25-7.20 (m, 1H), 5.28-5.17 (m, 2H), 4.46 (t, J = 5.2 Hz, 1H), 4.00-3.90 (m, 2H), 3.82-3.72 (m, 1H), 3.02-2.90 (m, 2H), 2.79 (s, 3H), 2.55 (d, J = 14.0 Hz, 1H), 2.09 (d, J = 14.0 Hz, 1H), 1.32 (d, J = 6.0 Hz, 3H), 1.00 (t, J = 7.2 Hz, 3H), 0.55-0.48 (m, 6H). ES-API: [M+H] + = 551.2, 553.2.

[0222] The structure of the other intermediate compound is: 3-((S a The result was )-2-(5-(benzyloxy)-2-((1S)-1-methoxyethyl)pyridine-3-yl)-5-bromo-1-ethylindole-3-yl)-2,2-dimethylpropyl-1-ol(11-e-2,210 mg, 0.381 mmol, yield 30.13%). ES-API: [M+H] + = 551.2, 553.2.11-e-2:Rt=1.758min(3min LCMS).

[0223] Step 7: Under nitrogen gas protection, compound 11-e-1 (18g, 32.6 mmol), bis(pinacolate)diborone (16.6g, 65.2 mmol), potassium acetate (6.41g, 65.27 mmol), and Pd(dppf)Cl2 (2.39g, 3.26 mmol) were mixed in anhydrous toluene (200 mL) and stirred at 90°C for 4 hours. After the reaction was complete, the mixture was cooled, concentrated to remove toluene, and 300 mL of ethyl acetate and 500 mL of water were added. The mixture was extracted three times with ethyl acetate, and then sequentially washed with 500 mL of water and 500 mL of saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-50% petroleum ether / ethyl acetate) to obtain compound intermediate 11 (20.8 g, yield 85%). ES-API[M+H] + = 599.3.

[0224] Single crystal culture of intermediate 11-e-1 Single crystal culture: Approximately 10 mg of intermediate 11-e-1 powder sample was weighed, 1 mL of acetonitrile was added, and the mixture was completely dissolved by sonication. The solvent was slowly evaporated in a Coubord, and after a while, yellowish-brown needle-shaped crystals precipitated, which were single crystals of intermediate 11-e-1. X-ray single crystal diffraction measurements were performed using a Bruker D8 Venture instrument. The results are shown in Table 1 and Figure 1 below. Figure 1 is an elliptical graph of the molecular three-dimensional structure.

[0225] Structural analysis and refinement process: After integral reduction of the diffraction data using the SAINT program, absorption correction was empirically performed using the SADABS program. The single crystal structure was analyzed using the direct method employing SHELXT2014, and the structure was refined using the least squares method. The refinement process of hydrogen atoms was determined by isotropy calculations, hydrogen atoms on nitrogen (N) and oxygen (O) were determined from the residual electron density, hydrogen atoms on CH were added by calculation, and refined using the Riding model. The Flack constant is 0.035(14), C22 in Figure 1 has an S absolute configuration, and the axial chirality at positions C9-C17 is R a It's the arrangement.

[0226] Crystal data: [Table 1]

[0227] Manufacturing Example 4: Synthesis of Intermediate 10-1 TIFF2026530065000143.tif38124 Step 1: (S)-1-Boc-3-carboxypyrrolidine (1.14 g, 5.285 mmol) was dissolved in dichloromethane (40 mL), and at 0°C, N-methyl-L-valine methyl hydrochloride (800 mg, 4.404 mmol), 2-(7-azobenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate (2.51 g, 6.606 mmol), and N,N'-diisopropylethylamine (2.84 g, 22.019 mmol) were added and the mixture was reacted at room temperature for 1 hour with stirring. Water (15 mL) was added to the reaction mixture and extracted with dichloromethane (25 mL). The organic phase was washed with saturated saline solution (15 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The crude product was purified by flash silica gel column chromatography (tetrahydrofuran / petroleum ether: 0-30%) to obtain compound intermediate 10-1 (900 mg, yield 59.7%), which was a colorless liquid. ES-API: [M+Na] + = 365.2.

[0228] Manufacturing Example 5: Synthesis of Intermediate 62-1 TIFF2026530065000144.tif66167 TIFF2026530065000145.tif43170TIFF2026530065000146.tif70170TIFF2026530065000147.tif48170 TIFF2026530065000148.tif52148 Step 1: Under nitrogen gas protection, compound 15-6 (10.5 g, 34.63 mmol), racemic (R)-2-(1-methoxyethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (16.6 g, 63.084 mmol), CataCXium A Pdg3 (2.52 g, 3.463 mmol), toluene (30 mL), water (30 mL), and potassium phosphate (22.05 g, 103.892 mmol) were mixed with dioxane (90 mL) and stirred at 110°C for 4 hours. After the reaction was complete, 300 mL of ethyl acetate was added, followed by sequential washing with 150 mL of water and 150 mL of saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-80% petroleum ether / ethyl acetate) to obtain compound 62-a (12 g, 33.382 mmol, yield 96.40%). ES-API[M+H] + = 360.3.

[0229] Step 2: Under nitrogen gas protection, compound 62-a (9.5g, 26.428 mmol) was dissolved in tetrahydrofuran (300 mL), cooled to 0°C, and lithium aluminum hydride solution (52.856 mL, 52.856 mmol) was gradually added. The mixture was stirred at room temperature for 1 hour, diluted with an appropriate amount of tetrahydrofuran, cooled to 0°C, and slowly added 2 mL of water and 2 mL of 15% sodium hydroxide aqueous solution. 6 mL of water was added, the mixture was heated to room temperature, stirred for 15 minutes, a small amount of anhydrous sodium sulfate was added, stirred for 15 minutes, and then filtered to remove the salts. The filtered cake was washed with ethyl acetate, concentrated, dried, and purified by silica gel column chromatography (petroleum ether / ethyl acetate = 10:90). Compound 62-b (2.8g, 8.447 mmol, yield 31.96%, retention time: 1.54 minutes, structure arbitrarily specified), ES-API[M+H] + =332.2, and 62-sp (2.5g, 7.53 mmol, yield 28.549%, retention time 1.51 minutes, structure arbitrarily specified), ES-API[M+H] + We obtained = 332.2.

[0230] Step 3: Under nitrogen gas protection, compound 62-b (2g, 6.034 mmol) and NBS (2.15g, 12.068 mmol) were mixed in N,N-dimethylformamide (5mL) and stirred at 50°C for 2 hours. After the reaction was complete, 30mL of ethyl acetate was added, and the mixture was sequentially washed with 15mL of water and 15mL of saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-80% petroleum ether / ethyl acetate) to obtain compound 62-c (2.2g, 5.361 mmol, yield 88.85%), and ES-API[M+H] + = 410.1 / 412.1.

[0231] Step 4: Under nitrogen gas protection, compound 62-c (2g, 4.874 mmol), DMAP (0.06g, 0.487 mmol), acetic anhydride (0.915 mL, 9.748 mmol), and DIPEA (1.89g, 14.621 mmol) were mixed with dichloromethane (50 mL) and stirred at 60°C for 18 hours. After the reaction was complete, 100 mL of dichloromethane was added, and the mixture was sequentially washed with 150 mL of water and 150 mL of saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated to obtain compound 62-d (2.2g, 4.87 mmol, yield 100%), and ES-API[M+H] + The result was 452.1 / 454.1.

[0232] Step 5: Under nitrogen gas protection, compound 62-d (2.2 g, 4.863 mmol), bis(pinacolate)diborone (2.47 g, 9.726 mmol), 1,5-cyclooctadiene iridium chloride dimer (0.16 g, 0.243 mmol), and 4,4'-di-t-butyl-2,2'-bipyridine (0.13 g, 0.486 mmol) were mixed in cyclohexane (50 mL) and stirred at 80°C for 18 hours. After the reaction was complete, the mixture was concentrated to obtain the crude product, compound 62-e (2.38 g).

[0233] Step 6: Compound 62-e (2.38 g, 4.8 mmol) was dissolved in acetonitrile (60 mL), H2O2 (1.632 mL, 14.400 mmol) was added at 0°C, and the mixture was stirred at 20°C for 2 hours. After the reaction was complete, 100 mL of ethyl acetate and excess Na2S2O3 solution were added, and the mixture was sequentially washed with 150 mL of water and 150 mL of saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-80% petroleum ether / ethyl acetate) to obtain compound 62-f (1.4 g, 2.989 mmol, 2-step yield: 62%), and ES-API[M+H] + The result was 468.1 / 470.1.

[0234] Step 7: Compound 62-f (800 mg, 1.708 mmol) was dissolved in methanol (3 mL), tetrahydrofuran (3 mL), and water (3 mL). Lithium hydroxide (286.67 mg, 6.832 mmol) was added to the above solution. After the addition was complete, the reaction was carried out at room temperature for 17 hours with stirring. After the reaction was complete, the reaction mixture was oxidized to a weakly acidic state (pH=6) with dilute hydrochloric acid (1 M). The obtained solution was extracted with ethyl acetate (20 mL x 3). The organic phase was washed with saturated brine (50 mL), and then dried and concentrated to obtain the crude product. The crude product was purified by flash silica gel column (ethyl acetate / petroleum ether: 0-100%) to obtain compound 62-g (700 mg, 1.642 mmol, yield 96.13%), which was a pale yellow solid. ES-API: [M+H] + = 426.1, 428.1.

[0235] Step 8: Compound 62-g (700 mg, 1.642 mmol) was dissolved in toluene (15 mL), dioxane (3 mL), and water (3 mL). Compound 15-2 (1355.67 mg, 2.463 mmol), potassium phosphate (871.22 mg, 4.105 mmol), and 1,1'-bis(di-t-butylphosphine)ferrocenepalladium dichloride (II) (160.32 mg, 0.246 mmol) were added to the above solution, and the mixture was purged three times with nitrogen gas and reacted with stirring at 80°C for 3 hours. Ethyl acetate (30 mL) and water (20 mL) were added to the reaction mixture. The organic phase was separated, washed with saturated brine (60 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The crude product was purified by flash silica gel column chromatography (tetrahydrofuran / petroleum ether: 0-50%) to obtain the target compound 62-h (1100 mg, 1.429 mmol, yield 87.02%), which was a gray solid. ES-API: [M+H] + = 770.3.

[0236] Step 9: Compound 62-h (1100 mg, 1.429 mmol) was dissolved in tetrahydrofuran (10 mL) and water (10 mL). Lithium hydroxide (85.72 mg, 3.572 mmol) was added at 0°C, and the reaction was carried out at room temperature for 18 hours with stirring. The reaction mixture was adjusted to pH 6 with 1 M dilute hydrochloric acid and extracted with ethyl acetate (20 mL x 3). The organic phase was dried over anhydrous sodium sulfate and concentrated to obtain compound 62-i (1000 mg, 1.323 mmol, yield 92.60%), which was an oily solid. ES-API: [M+H] + = 756.3.

[0237] Step 10: Compound 62-i (1100 mg, 1.455 mmol) was dissolved in dichloromethane (40 mL), and at room temperature, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (7811 mg, 40.745 mmol), 1-hydroxybenzotriazole (983 mg, 7.276 mmol), and diisopropylethylamine (7.6 mL, 43.655 mmol) were added to the solution. After the addition was complete, the mixture was reacted at room temperature for 18 hours with stirring. Dichloromethane (100 mL) was added to the reaction mixture, washed with dilute hydrochloric acid (0.5 M, 20 mL x 2) and saturated saline solution (100 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The crude product was purified by flash silica gel column chromatography (tetrahydrofuran / petroleum ether: 0-60%) to obtain the target compound 62-j (150 mg, 0.203 mmol, yield 13.97%), which was a white solid. ES-API: [M+H] + = 738.3.

[0238] Step 11: Compound 62-j (290 mg, 0.393 mmol) was dissolved in dichloromethane (10 mL). Triethylamine (0.164 mL, 1.179 mmol) and 1,1,1-trifluoro-N-phenyl-N-((trifluoromethyl)sulfonyl)methanesulfonamide (238.67 mg, 0.668 mmol) were added to the solution. After the addition was complete, the mixture was reacted at room temperature for 2 hours with stirring. After the reaction was complete, the reaction solution was concentrated to obtain the crude product. The crude product was purified by flash silica gel column (methanol / dichloromethane: 0%~3%) to obtain compound 62-k (300 mg, 0.345 mmol, yield 87.75%), which was a white solid. ES-API: [M + H] + = 870.1.

[0239] Step 12: Dissolve compound 62-k (50 mg, 0.057 mmol) in methanol (0.5 mL), add 4 M hydrochloric acid / dioxane (3 mL, 0.196 mmol), and react at room temperature under nitrogen gas protection for 1 hour. After the reaction is complete, concentrate under reduced pressure to obtain intermediate compound 62-1 (39 mg, 0.045 mmol, yield 86.68%), which is a yellow solid with ES-API: [M + H]+ The result was 770.2.

[0240] Production Example 6: Synthesis of Intermediate 62-p TIFF2026530065000149.tif33165 TIFF2026530065000150.tif41159 Step 1: To a solution of 4-cyano-4-(hydroxymethyl)hexahydropyridine-1-formate t-butyl (3.00 g, 12.4484 mmol) in tetrahydrofuran (150 mL), 2H-isoindole-1,3-dione (2.02 g, 13.733 mmol), PPh3 (5.87 g, 22.472 mmol), and DIAD (4.54 g, 22.472 mmol) were added, and the reaction mixture was stirred at 40°C for 3 hours. After the reaction was complete, water (100 mL) and ethyl acetate (100 mL) were added, the organic layer was separated, and then washed with saturated sodium chloride solution (100 mL x 3). The mixture was dried over anhydrous sodium sulfate, filtered, and concentrated. The compound was purified by silica gel column chromatography (ethyl acetate / petroleum ether = 1 / 2) to obtain compound 62-l (2500 mg, 6.767 mmol, yield 54.21%). ES-API: [M+H]+=370.1.

[0241] Step 2: Compound 62-l (2g, 5.414 mmol) was dissolved in dichloromethane (6 mL), trifluoroacetic acid (6.219 mL, 81.208 mmol) was added, and the mixture was reacted at room temperature for 1 hour. The reaction product was concentrated under vacuum and dried to obtain compound 62-m (1.45 g, crude product). ES-API: [M+H]+=270.1.

[0242] Step 3: Compound 62-m (1.45 g, crude product) was dissolved in acetonitrile (15 mL), potassium carbonate (2.31 g, 16.710 mmol) and 3-bromopropan-1-yne (0.53 g, 4.456 mmol) were added, and the mixture was reacted at room temperature for 3 hours. After the reaction was complete, water (50 mL) and ethyl acetate (50 mL) were added, and the organic layer was separated. The mixture was then washed with saturated sodium chloride solution (50 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated. The solution was purified by silica gel column chromatography to obtain compound 62-n (800 mg, 2.603 mmol, yield 46.73%). ES-API: [M+H] + = 308.1.

[0243] Step 4: Compound 62-n (800 mg, 2.603 mmol) was dissolved in ethanol (15 mL), and a 30% methylamine / methanol solution (4 g, 39.045 mmol) was added. The mixture was reacted at 80°C for 6 hours. After the reaction was complete, the mixture was concentrated to remove excess methylamine and obtain compound 62-o (980 mg, crude product). ES-API: [M+H]+=178.1.

[0244] Step 5: Compound 62-o (980 mg, crude product) was dissolved in tetrahydrofuran (15 mL), saturated sodium bicarbonate aqueous solution (5 mL) and di-t-butyl dicarbonate (1.12 mL, 5.2 mmol) were added, and the mixture was reacted for 1 hour. After the reaction was complete, water (50 mL) and ethyl acetate (50 mL) were added, and the organic layer was separated. The mixture was then washed with saturated sodium chloride solution (50 mL x 3), dried over anhydrous sodium sulfate, filtered, and concentrated. The mixture was purified by silica gel column chromatography to obtain compound 62-p (500 mg, 1.80 mmol, 2-step yield 69.3%). ES-API: [M+H] + = 278.1.

[0245] Manufacturing Example 7: Synthesis of Intermediate 8-8 TIFF2026530065000151.tif86170 Step 1: Compound 1-10 (5g, 9.22 mmol) was dissolved in N,N-dimethylformamide (50 mL), and 60% sodium hydride solid (0.55 g, 13.82 mmol) was gradually added under ice bath conditions, and the mixture was stirred for 0.5 hours. Then, benzenesulfonyl chloride (1.25 mL, 9.77 mmol) was added, and the mixture was stirred for another hour. The reaction mixture was quenched with 50 mL of saturated ammonium chloride solution and extracted three times with 50 mL of ethyl acetate. The organic phase was combined, washed with 50 mL of saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by flash silica gel column (0-5% tetrahydrofuran / petroleum ether) to obtain compound 8-8a (6.1 g), with a yield of 97% and an oily substance. ES-API: [M+H] + = 682.0.

[0246] Step 2: Under ice bath conditions, a 14.65 mL, 14.65 mmol solution of 1 M diisobutylaluminum hydride in n-hexane was added to a 30 mL solution of morpholine (1.31 g, 15.01 mmol) in tetrahydrofuran and stirred for 30 minutes. Then, a 30 mL solution of compound 8-8a (2.5 g, 3.66 mmol) in tetrahydrofuran was added to the reaction mixture and stirred at room temperature for 1 hour. After the reaction was complete, the mixture was quenched with 60 mL of 1 M hydrochloric acid and extracted three times with 60 mL of ethyl acetate. The organic phase was combined, dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-5% tetrahydrofuran / petroleum ether) to obtain compound 8-8b (2 g, yield 85%), which was an oily substance. ES-API: [M+H] + = 638.0.

[0247] Step 3: Compound 8-8b (2 g, 3.13 mmol) was dissolved in tetrahydrofuran (30 mL), tetrabutylammonium fluoride solution (5 mL, 5.00 mmol) was added, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was quenched with 10 mL of saturated ammonium chloride solution and extracted three times with 10 mL of ethyl acetate solution. The organic phase was combined, dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-8% methanol / dichloromethane) to obtain compound 8-8c (1.5 g, yield 96%), which was a yellow oily substance. ES-API: [M+H] + = 498.1.

[0248] Step 4: Under nitrogen gas protection, the compound 8-8c (1.5 g, 3.01 mmol), (S)-4-(6-(1-methoxyethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-yl)piperazine-1-formate t-butyl (2.02 g, 4.51 mmol, see US2021130303A1 for preparation method), [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium (0.44 g, 0.60 mmol), and potassium carbonate (1.25 g, 9.03 mmol) were mixed in water (4 mL) and dioxane (20 mL) and stirred at 100 °C for 2 hours. The reaction mixture was placed in 50 mL of ethyl acetate and washed sequentially with 15 mL of water and 15 mL of saturated saline solution. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-8% methanol / dichloromethane) to obtain compound 8-8d (1800 mg, yield 81%). ES-API: [M+H] + = 739.3.

[0249] Step 5: Compound 8-8d (1.2 g, 1.62 mmol) was dissolved in tetrahydrofuran (15 mL), and 60% sodium hydride solid (0.19 g, 4.87 mmol) was gradually added under ice bath conditions, and the mixture was stirred for 0.5 hours. Then, iodoethane (0.39 mL, 4.87 mmol) was added, and the mixture was stirred for another hour. The reaction mixture was quenched with 20 mL of saturated ammonium chloride solution and extracted three times with 20 mL of ethyl acetate. The organic phase was combined, washed with 20 mL of saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by flash silica gel column (0-2.5% methanol / dichloromethane) to obtain compound 8-8e (900 mg, yield 72%), which was an oily substance. ES-API: [M+H] + = 767.3.

[0250] Step 6: At -60°C, a 2.5 M solution of n-butyllithium in tetrahydrofuran (0.7 mL, 1.76 mmol) was added to a 2,2,6,6-tetramethylpiperazine (250 mg, 1.76 mmol) solution in tetrahydrofuran (20 mL), and the mixture was stirred for 0.5 hours. The temperature was then raised to 0°C, and a bis[(pinacolato)boryl]methane (472 mg, 1.76 mmol) solution in tetrahydrofuran (2 mL) was added, and the mixture was stirred for 10 minutes. The mixture was cooled again to -60°C, and a compound 8-8e (900 mg, 1.17 mmol) solution in tetrahydrofuran (5 mL) was added, and the mixture was stirred for 3 hours. The reaction mixture was concentrated and purified by flash silica gel column (0-6% tetrahydrofuran / petroleum ether) to obtain the intermediate compound 8-8 (1000 mg, yield 95.67%). ES-API: [M+H] + = 891.4.

[0251] Manufacturing Example 8: Synthesis of Intermediate 8-8 TIFF2026530065000152.tif45170 TIFF2026530065000153.tif41170 TIFF2026530065000154.tif62118 Step 1: Under nitrogen gas protection, a dioxane / water (10 mL / 2 mL) solution of compound 1-10 (4.5 g, 8.29 mmol), 2-[(1S)-1-methoxyethyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (3.71 g, 8.29 mmol; see US2021130303A1 for preparation method), [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium (0.61 g, 0.83 mmol), and potassium carbonate (3.44 g, 24.88 mmol) was stirred at 120°C for 2 hours. After the reaction was complete, 30 mL of ethyl acetate was added, and the mixture was washed with 15 mL of water and 15 mL of saturated saline solution. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-60% tetrahydrofuran / petroleum ether) to obtain compound 8-3 (4.3g, yield 66%). ES-API: [M+H] + = 783.3.

[0252] Step 2: Compound 8-3 (4.3 g, 5.491 mmol) was dissolved in tetrahydrofuran (50 mL), cooled to 0°C, and gradually added to sodium hydride (1.10 g, 27.46 mmol), stirring for 0.5 hours. Then, iodoethane (1 mL, 12.50 mmol) was added to the reaction mixture, and stirring continued for 2 hours. The reaction mixture was quenched with 10 mL of saturated ammonium chloride solution and extracted three times with 10 mL of ethyl acetate. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-30% tetrahydrofuran / petroleum ether) to obtain compound 8-4 (4200 mg, yield 94.30%), a yellow oily substance. ES-API: [M+H] + = 811.3.

[0253] Step 3: Under nitrogen gas protection, compound 8-4 (500 mg, 0.616 mmol) was dissolved in tetrahydrofuran (10 mL), cooled to -70°C, then diisobutylaluminum hydride (3.08 mL, 3.08 mmol) was added and the mixture was stirred for 1 hour. After the reaction was complete, the reaction was quenched with sodium sulfate decahydrate and purified by flash silica gel column (0-50% tetrahydrofuran / petroleum ether) to obtain compound 8-5 (200 mg, 42% yield), a yellow oily substance. ES-API: [M+H] + = 769.3.

[0254] Step 4: To a solution of compound 8-5 (200 mg, 0.260 mmol) in dichloromethane (5 mL), Dess-Martin oxidizing agent (132 mg, 0.31 mmol) was added and the mixture was stirred at room temperature for 1 hour. After the reaction was complete, 30 mL of dichloromethane was added and the mixture was washed with 10 mL of water. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-50% tetrahydrofuran / petroleum ether) to obtain compound 8-6 (200 mg, 100% yield). ES-API: [M+H] + = 767.3.

[0255] Step 5: Under conditions of -70°C, a solution of n-butyllithium in tetrahydrofuran (0.28 mL, 0.70 mmol) was gradually added to a solution of trimethylsilyldiazomethane (0.35 mL, 0.70 mmol) in tetrahydrofuran (2 mL), and the mixture was stirred for 0.5 hours. Then, a solution of compound 8-6 (180 mg, 0.24 mmol) in tetrahydrofuran (2 mL) was added to the above solution, and the mixture was stirred for 1 hour. The reaction mixture was quenched with 5 mL of saturated ammonium chloride solution and extracted three times with 5 mL of ethyl acetate. The organic phase was combined, dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-80% tetrahydrofuran / petroleum ether) to obtain compound 8-7 (120 mg, yield 67.02%). ES-API: [M+H] + = 763.4.

[0256] Step 6: Under nitrogen gas protection, solutions of cuprous chloride (8 mg, 0.08 mmol), sodium t-butoxide (15 mg, 0.16 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (46 mg, 0.08 mmol) in tetrahydrofuran (1 mL) were stirred at room temperature for 30 minutes. Then, a solution of bis(pinacorato)diborone (48 mg, 0.19 mmol) in tetrahydrofuran (1 mL) was added and stirred for another 10 minutes. Finally, compound 8-7 (120 mg, 0.16 mmol) and methanol (0.013 mL, 0.32 mmol) were added sequentially and stirred for 3 hours. The reaction mixture was directly concentrated and further purified by flash silica gel column (0-60% tetrahydrofuran / petroleum ether) to obtain the white solid compound 8-8 (80 mg, yield 57%). ES-API: [M+H] + = 891.3.

[0257] Manufacturing Example 9: Synthesis of Intermediate 15-20-1 TIFF2026530065000155.tif55170 Step 1: 62-k (250 mg, 0.287 mmol) was dissolved in acetonitrile (5 mL). At room temperature, 4-(prop-2-in-1-yl)thiomorpholine-1,1-dioxide (149.34 mg, 0.862 mmol), bistriphenylphosphine palladium dichloride (40.34 mg, 0.057 mmol), cuprous iodide (111.43 mg, 0.862 mmol), N,N'-diisopropylethylamine (111.43 mg, 0.862 mmol), and lithium chloride (48.73 mg, 1.149 mmol) were added to the above solution. After the addition was complete, the reaction was carried out at 80°C under an argon gas atmosphere with stirring for 1 hour. After the reaction was complete, water (30 mL) was added to the reaction mixture, and it was further extracted with ethyl acetate (30 mL x 3). The organic phase was washed with saturated saline solution (30 mL x 2), then dried and concentrated to obtain the crude product. The crude product was purified by flash silica gel column chromatography (methanol / dichloromethane: 0%~3%) to obtain intermediate 15-19-1 (150 mg, 0.168 mmol, yield 58.31%), which was a white solid. ES-API: [M +H] += 893.2.

[0258] Step 2:0 o At C, a 4M dioxane hydrochloride solution (4 mL) was added to a methanol solution (8 mL) of compound 15-19-1 (150 mg, 0.168 mmol). The reaction mixture was stirred at room temperature for 3 hours, and completion of the reaction was detected by LC-MS. The pH of the reaction system was adjusted to 6-7, and the mixture was concentrated under reduced pressure to obtain the crude product, compound 15-20-1 (125 mg), which was then directly used to proceed to the next reaction. ES-API: [M +H] + = 793.2.

[0259] Example 1 Synthesis of compounds Z1-1 and Z1-2 TIFF2026530065000156.tif34170TIFF2026530065000157.tif7395TIFF2026530065000158.tif56170 TIFF2026530065000159.tif49170 TIFF2026530065000160.tif43170 TIFF2026530065000161.tif44162 TIFF2026530065000162.tif48136 Step 1: Under nitrogen gas protection, dried N,N-dimethylformamide (50 mL) was added to zinc powder (20 g, 306 mmol). Then trimethylchlorosilane (4 mL, 31.55 mmol) was added and the mixture was stirred at 90°C for half an hour. After cooling and standing, most of the N,N-dimethylformamide was removed with a syringe. Another 20 mL of N,N-dimethylformamide was added, the mixture was stirred for half an hour, and after standing, most of the N,N-dimethylformamide was removed with a syringe. This process was repeated three times. Dried N,N-dimethylformamide (50 mL) was added to activated zinc powder, cooled to 0°C, and gradually N,N-dimethylformamide (50 mL) of (R)-2-((t-butoxycarbonyl)amino)-3-iodopropanoate t-butyl (11 g, 33.42 mmol) was added, the mixture was stirred for half an hour, and after standing, the corresponding zinc reagent was obtained. The obtained zinc reagent solution (60 mL) was added to N,N-dimethylformamide (60 mL) containing (2-bromothiazole-4-yl)carbamate t-butyl (3 g, 10.75 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium (0.79 g, 1.08 mmol), and the reaction was carried out at 70°C for 6 hours. After the reaction was complete, 400 mL of ethyl acetate was added, and the mixture was sequentially washed with 100 mL of saturated saline solution and 100 mL of water. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-40% ethyl acetate / petroleum ether) to obtain compound 1-1 (3.6 g, yield 83%), which was a yellow solid. ES-API:[M+H] + = 402.1.

[0260] Step 2: Lithium hydroxide (1.32 g, 31.38 mmol) was added to compound 1-1 (4.2 g, 10.46 mmol) in tetrahydrofuran (40 mL) and water (8 mL), and the mixture was stirred at room temperature for 2 hours. After the reaction was complete, the pH was neutralized to 6 with 1 M hydrochloric acid solution, and the mixture was extracted three times with 40 mL of ethyl acetate. The organic phase was combined, dried over anhydrous sodium sulfate, filtered, and concentrated to obtain compound 1-2 (3.9 g), which was a yellow solid. ES-API:[M+H] + = 388.1.

[0261] Step 3: Under ice bath conditions, (S)-hexahydropyridazine-3-carboxylate methylbis(trifluoroacetate) (5.62 g, 15 mmol), N-methylmorpholine (11 mL, 101 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (3.86 g, 20 mmol), and 1-hydroxybenzotriazole (0.41 g, 3 mmol) were sequentially added to a solution of compound 1-2 (3.9 g, 10 mmol) in dichloromethane (40 mL), and the mixture was stirred at room temperature for 3 hours. After the reaction was complete, the mixture was quenched with 40 mL of 1 M hydrochloric acid solution and extracted three times with 20 mL of dichloromethane. The organic phase was combined, dried over anhydrous sodium sulfate, filtered, concentrated, and further purified by flash silica gel column (0-45% tetrahydrofuran / petroleum ether) to obtain compound 1-3 (4 g, yield 77%), which was a white solid. ES-API:[M+H] + = 514.2.

[0262] Step 4: Compound 1-3 (1 g, 1.95 mmol) was dissolved in dichloromethane (3 mL), trifluoroacetic acid (3 mL) was added, and the mixture was stirred at room temperature for 2 hours. The mixture was concentrated and further dissolved in dichloromethane (3 mL), and N,N-diisopropylethylamine (3 mL, 17 mmol) and di-t-butyl dicarbonate (1 mL, 4.35 mmol) were added, and the mixture was stirred for 0.5 hours. After the reaction was complete, the mixture was washed with 10 mL of water, concentrated, and further purified by flash silica gel column (0-10% methanol / dichloromethane) to obtain compound 1-4 (300 mg, yield 37%). ES-API:[M+H] + = 414.3.

[0263] Step 5: Under nitrogen gas protection, a tetrahydrofuran solution of lithium aluminum hydride (40 mL, 40,000 mmol) was added dropwise to a tetrahydrofuran solution of 2,2-dimethyl-4-pentenoic acid (5 g, 39 mmol) (100 mL) in an ice bath, and the mixture was stirred at room temperature for 4 hours. The reaction mixture was sequentially quenched with water (2.6 mL), 10% sodium hydroxide solution (2.6 mL), and water (7.2 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to obtain compound 1-5 (3.5 g, yield 78%), which was a colorless oil.

[0264] Step 6: Under ice bath conditions, imidazole (2.30 g, 33.72 mmol) and t-butyldiphenylchlorosilane (8 mL, 30.65 mmol) were added to a solution of compound 1-5 (3.5 g, 30.65 mmol) in dichloromethane (50 mL), and the mixture was stirred at room temperature for 1 hour. The reaction mixture was filtered and washed with 50 mL of water. The organic phase was dried and concentrated, and further purified by flash silica gel column (0-30% ethyl acetate / petroleum ether) to obtain compound 1-6 (9 g, yield 83%).

[0265] Step 7: Under ice bath conditions, compounds 1-6 (6.9 g, 19.57 mmol) were dissolved in tetrahydrofuran (30 mL) and water (30 mL). Potassium osmate dihydrate (360 mg, 1 mmol), 2,6-dimethylpyridine...

Claims

1. A compound represented by formula (I), or a stable deuterated derivative thereof, stereoisomer, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, (I) Eventually, Ring A is or And, is a phenyl group, a 5 or 6-membered heteroaryl group, or a 5 or 6-membered heterocyclyl group, wherein one or two ring atoms of the 5 or 6-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur, and one or two ring atoms of the 5 or 6-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur, and the 5 or 6-membered heterocyclyl group is a fully saturated heterocyclyl group or a partially unsaturated heterocyclyl group, or among them, W １ is CH, C, or N, and W ２ is CH, C, or N, and W ３ CR １３ , O, S, N or NH, W ４ CR １３ , O, S, N or NH, W ５ It does not exist, or it is O or CR. １４ And, This indicates the connection point with the left side. W ６ is selected from CR １３ or N X is 、 or And, Y １ It is N or CH, and of which N is oxidized to (N ＋ -O － ) is also acceptable, Y ２ It is N or CH, and of which N is oxidized to (N ＋ -O － ) is also acceptable, R ４２ C is hydrogen, halogen, substituted or unsubstituted １－６ It is an alkyl group, R ４３ C is hydrogen, halogen, substituted or unsubstituted １－６ It is an alkyl group, or R ４２ and R ４３ These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. ３－６ Forming a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclyl group, R ４０ C is hydrogen, halogen, substituted or unsubstituted １－６ It is an alkyl group, R ４１ C is hydrogen, halogen, substituted or unsubstituted １－６ It is an alkyl group, or R ４０ and R ４１ It combines to form -CH ２ - or -CH ２ CH ２ - forms, and of which -CH ２ - or -CH ２ CH ２ - indicates an optional choice of deuterium, halogen, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Substituted with one or more groups selected from alkyl groups, Ring A If L １ ha-N(R ００ )C(=O)-,-N(R ００ )C(=O)-O-,-C １－４ Alkyl-N(R) ００ )C(=O)-, -C(=O)N(R ００ )-C １－４ Alkyl-, -C １－４ Alkyl-N(R) ００ ) C (=S) -, - substitution or unsubstituted C １－６ Alkyl-O-,-substituted or unsubstituted C ２－６ Alkenyl-O-, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ Aryl group, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl group, -L ２ - Substituted or unsubstituted C ６－１０ aryl-, -L ２ -Substituted or unsubstituted 5 or 6-membered monocyclic heteroaryls-, -L ２ - Substituted or unsubstituted 8 or 10-membered bicyclic heteroaryl - or -L ２ - Substituted or unsubstituted 3- to 8-membered heterocyclyl - L ２ is C ３－６ Cycloalkyl group, 3- to 8-membered heterocyclyl group, -O-, -C １－４ Alkyl-, -N(R) ００ )-, -C(=O)-, -CR ０９ =CR １０ -, -N(R ００ )C(=O)- or -N(R ００ ) C (= S) -, Ring A If that is the case, W １ , W ２ , W ３ , W ４ , W ５ If at least one of them is a heteroatom selected from O, S, N, or NH, then L １ ha-N(R ００ )C(=O)-,-N(R ００ )C(=O)-O-,-C １－４ Alkyl-N(R) ００ )C(=O)-, -C(=O)N(R ００ )-C １－４ Alkyl-, -C １－４ Alkyl-N(R) ００ ) C (=S) -, - substitution or unsubstituted C １－６ Alkyl-O-,-substituted or unsubstituted C ２－６ Alkenyl-O-, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ Aryl group, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl group, -L ２ - Substituted or unsubstituted C ６－１０ aryl-, -L ２ - Substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl - or -L ２ - Substituted or unsubstituted 3- to 8-membered heterocyclyl - L ２ is -O-, -C １－４ alkyl-, -N(R ００ )-, -C(=O)-, -CR ０９ =CR １０ -, -N(R ００ )C(=O)- or -N(R ００ )C(=S)-, Or, W １ , W ２ are both C, and W ３ , W ４ , W ５ are all CH, then L １ is -N(R ００ )C(=O)-O-, -C １－４ alkyl-N(R ００ )C(=O)-, -N(R ００ )C(=O)-C １－４ alkyl-, -C １－４ alkyl-N(R ００ )C(=S)-, substituted or unsubstituted C １－６ alkyl-O- or substituted or unsubstituted C ２－６ alkenyl-O-, R ００ is hydrogen or C １－６ It is an alkyl group, R １ is hydrogen, deuterium, halogen, hydroxyl group, C １－６ Alkyl alkyl group, substituted or unsubstituted C １－６ It is a heteroalkyl group, R ２ is hydrogen, deuterium, halogen, C １－６ Alkyl alkyl group, substituted or unsubstituted C １－６ It is a heteroalkyl group, R ３ａ is C １－６ Alkyl or deuterated C １－６ It is an alkyl group, R ４ａ is a substituted or unsubstituted C １－６ Alkyl alkyl groups, substituted or unsubstituted C ３－６ A cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclyl group, R ５ is hydrogen, -NR ０１ R ０２ , -C(R ０５ ) R ０３ R ０４ , -C １－４ Alkyl-NR ０１ R ０２ , -C １－４ Alkyl-C (R ０５ ) R ０３ R ０４ , -C １－４ Alkyl-C(=O)-NR ０１ R ０２ , -C １－４ Alkyl-C(=O)-C(R ０５ ) R ０３ R ０４ , -C １－４ Alkyl-C(=O)-C １－４ Alkyl-NR ０１ R ０２ , -C １－４ Alkyl-C(=O)-C １－４ Alkyl-C (R ０５ ) R ０３ R ０４ , -C １－４ Alkyl-N(R) ０６ )C(=O)-NR ０１ R ０２ , -C １－４ Alkyl-N(R) ０６ )C(=O)-C(R ０５ ) R ０３ R ０４ , -C １－４ Alkyl-N(R) ０６ )C(=O)-C １－４ Alkyl-NR ０１ R ０２ , -C １－４ Alkyl-N(R) ０６ )C(=O)-C １－４ Alkyl-C (R ０５ ) R ０３ R ０４ , -O-C １－４ Alkyl-NR ０１ R ０２ , -O-C １－４ Alkyl-C (R ０５ ) R ０３ R ０４ , -O-C １－４ Alkyl-N(R) ０６ )C(=O)-R ０３ , -O-C(R ０５ ) R ０３ R ０４ , -C １－４ Alkyl-NR ０１ R ０２ , -C １－４ Alkyl-C (R ０５ ) R ０３ R ０４ , -N(R ０６ )C(=O)-NR ０１ R ０２ , -N(R ０６ )C(=O)-C(R ０５ ) R ０３ R ０４ , -C ２－４ Alkinyl-NR ０１ R ０２ , -C ２－４ Alkinyl-C(=O)-NR ０１ R ０２ , -C ２－４ Alkinyl-C(R) ０５ ) R ０３ R ０４ , -C １－４ Alkyl-C ２－４ Alkinyl-NR ０１ R ０２ , -C １－４ Alkyl-C ２－４ Alkinyl-C(R) ０５ ) R ０３ R ０４ , -C ２－４ Alkinyl-C １－４ Alkyl-NR ０１ R ０２ , -C ２－４ Alkinyl-C １－４ Alkyl-C (R ０５ ) R ０３ R ０４ , -C １－４ Alkyl-C ２－４ Alkinyl-C １－４ Alkyl-NR ０１ R ０２ -CH=CR ０１ R ０２ , -C ２－４ Alkenil-NR ０１ R ０２ , -C ２－４ Alkenyl-C(R) ０５ ) R ０３ R ０４ , -C １－４ Alkyl-C ２－４ Alkenil-NR ０１ R ０２ , -C １－４ Alkyl-C ２－４ Alkenyl-C(R) ０５ ) R ０３ R ０４ , -C ２－４ Alkenyl-C １－４ Alkyl-NR ０１ R ０２ , -C ２－４ Alkenyl-C １－４ Alkyl-C (R ０５ ) R ０３ R ０４ , -C １－４ Alkyl-C ２－４ Alkenyl-C １－４ Alkyl-NR ０１ R ０２ -C = CR ０３ R ０４ , -O-C １－４ Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl groups, -O-C １－４ Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl group, -O-C １－４ Alkyl-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -O-substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, -O-substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, -O-substituted or unsubstituted 7-12 membered bicyclic heterocyclyl groups, -N=S(=O)(R ０６ ) (-C １－４ Alkyl-NR ０１ R ０２ ), -N(R ０６ )-S(=O)(-C １－４ Alkyl-NR ０１ R ０２ ), -S(=O)(R ０６ ) (= N-R ０６ ), -S(=O)(-C １－４ Alkyl-NR ０１ R ０２ ) (= N-R ０６ ), -S (=O) ２ (-C １－４ Alkyl-NR ０１ R ０２ ), -S(=O)(-C １－４ Alkyl-NR ０１ R ０２ ), -S (=O) ２ (-C １－４ Alkyl-C (R ０５ ) R ０３ R ０４ ), -S(=O)(-C １－４ Alkyl-C (R ０５ ) R ０３ R ０４ ), -C ２－４ Alkynyl-substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, -C ２－４ Alkynyl-substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl group, -C ２－４ Alkynyl-substituted or unsubstituted 6- to 12-membered heteroaryl group condensed heterocyclyl group, substituted or unsubstituted C ６－１０ Aryl groups, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl groups, substituted or unsubstituted 8 to 10-membered bicyclic heteroaryl groups, substituted or unsubstituted C ６－１０ Aryl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl group, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl group, substituted or unsubstituted C ６－１０ Aryl-C １－４ Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl group, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl-C １－４ Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl group, substituted or unsubstituted C ６－１０ 3- to 8-membered monocyclic heterocyclyl groups with aryl group condensation substitution or unsubstituted, substituted or unsubstituted 5 or 6-membered monocyclic heterocyclyl groups with 5 or 6-membered monocyclic heteroaryl group condensation substitution or unsubstituted, substituted or unsubstituted C ６－１０ Aryl-C １－４ Alkyl-NR ０１ R ０２ , substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl-C １－４ Alkyl-NR ０１ R ０２ And, R ０１ , R ０２ Each is independently hydrogen, substituted or unsubstituted C １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Alkoxy group, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted C ２－６ Alkenyl group, substituted or unsubstituted C ２－６ Selected from alkynyl groups, or R ０１ , R ０２ These, together with the nitrogen atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups. R ０３ , R ０４ Each is independently hydrogen, substituted or unsubstituted C １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Alkoxy group, substituted or unsubstituted C ２－６ Alkenyl group, substituted or unsubstituted C ２－６ Selected from alkynyl groups, of which the C １－６ Alkyl alkyl group, C １－６ Two hydrogen atoms bonded to the same carbon atom on the alkoxy group are arbitrarily selected and simultaneously -(CH ２ ) ｊ It is substituted with - to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or R ０３ , R ０４ These, together with the carbon atoms linked to them, form substituted or unsubstituted substituted or unsubstituted substituted or unsubstituted 5-15 membered tricyclic heterocyclyl groups, 7-12 membered bicyclic heterocyclyl groups, substituted or unsubstituted 3-8 membered monocyclic heterocyclyl groups, substituted or unsubstituted 5 or 6 membered monocyclic heteroaryl groups, or substituted or unsubstituted 8-10 membered bicyclic heteroaryl groups. R ０５ Hydrogen, deuterium, halogens, deuterated C １－６ Alkyl alkyl group or C １－６ It is an alkyl group, R ０６ is hydrogen, deuterium, or C １－６ It is an alkyl group, Y ３ Ha-C(=O)R ６ , -C(=S)R ６ , -S (=O) (R ０７ ) (= N-R ０８ ), -S(=O)(R ０７ ) (Caution ０８ ), -S (=O) ２ (R ０７ ) (Caution ０８ ), -P(=O)(R ０７ ) (Caution ０８ ), -C(=O)-C １－４ Alkyl-NR ６ -S (=O) (R ０７ ) (= N-R ０８ ), -C(=O)-C １－４ Alkyl-N=S(=O)(R ０７ ) (Caution ０８ ) or R １１ And R １２ is hydrogen, C １－６ Alkyl or deuterated C １－６ It is an alkyl group, Alternatively, Y ３ , R １２ These, together with the nitrogen atoms linked to them, form substituted or unsubstituted nitrogen-containing 3-8 membered heterocyclyl groups, where one ring atom of the nitrogen-containing 3-8 membered heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. R ６ is a substituted or unsubstituted C １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Heteroalkyl groups, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8 to 10-membered bicyclic heteroaryl group, R １１ This is a substituted or unsubstituted 3-10 member heterocyclyl group, a substituted or unsubstituted 5 or 6 member monocyclic heteroaryl group, a substituted or unsubstituted 8-10 member bicyclic heteroaryl group, a substituted or unsubstituted 6-12 member heteroaryl group condensed cycloalkyl group, a substituted or unsubstituted 6-12 member heteroaryl group condensed heterocyclyl group, a substituted or unsubstituted 7-12 member bicyclic heterocyclyl group, or a substituted or unsubstituted 5-15 member tricyclic heterocyclyl group. R ０７ C is hydrogen, deuterium, substituted or unsubstituted C １－６ Alkyl alkyl group, substituted or unsubstituted C ３－６ It is a cycloalkyl group, and the substitutions are deuterium, C １－６ Alkyl alkyl group, C １－６ This means that the group is substituted with one or more groups (e.g., one, two, three, or four) selected from the group consisting of heteroalkyl groups and five- or six-membered monocyclic heteroaryl groups. R ０８ C is hydrogen, deuterium, substituted or unsubstituted C １－６ Alkyl alkyl group, substituted or unsubstituted C ３－６ It is a cycloalkyl group, and the substitutions are deuterium, C １－６ Alkyl alkyl group, C １－６ This means that the group is substituted with one or more groups (e.g., one, two, three, or four) selected from the group consisting of heteroalkyl groups and five- or six-membered monocyclic heteroaryl groups. R ０９ C is hydrogen, deuterium, halogen, or substituted or unsubstituted C １－６ It is an alkyl group, and the substitution means that it is substituted with one or more (for example, 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. R １０ C is hydrogen, deuterium, halogen, or substituted or unsubstituted C １－６ It is an alkyl group, and the substitution means that it is substituted with one or more (for example, 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. Y ５ is O or S, Y ４ is O or S, R ３ C is hydrogen, substituted or unsubstituted. １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Heteroalkyl groups, substituted or unsubstituted C ２－６ Alkenyl group, substituted or unsubstituted C ２－６ Alkynyl group, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8 to 10-membered bicyclic heteroaryl group, R １３ C is hydrogen, halogen, substituted or unsubstituted １－６ Alkyl alkyl group, substituted or unsubstituted C １－６ It is an alkoxy group, R １４ C is hydrogen, halogen, substituted or unsubstituted １－６ It is an alkyl group, or W ４ and W ５ In R １３ and R １４ These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. ３－６ Cycloalkyl groups, substituted or unsubstituted C ６－１０ Forms an aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 3 to 8-membered heterocyclyl group, W ５ In R １４ and R ３ These, together with the atoms linked to them, form a substituted or unsubstituted nitrogen-containing 4-8 member monocyclic heterocyclyl group, wherein one ring atom of the nitrogen-containing 4-8 member monocyclic heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, or W ６ In R １３ and R ３ These, together with atoms linked to them, form a substituted or unsubstituted nitrogen-containing 3- to 8-membered monocyclic heterocyclyl group or a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, wherein one ring atom of the nitrogen-containing 3- to 8-membered monocyclic heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. In each of the above groups, the substitution means that each group is independently substituted with one, two, three, four, five, or six groups selected from group S1, and each of the groups in group S1 is independently -SF ５ Deuterium, oxo (=O), thio (=S), =CR ｅ R ｆ , = NR ｅ , halogen, cyano group, hydroxyl group, carboxyl group, nitro group, C １－６ Alkyl alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Alkoxy group, C ３－２０ Cycloalkyl group, 3-20 membered heterocyclyl group, C ６－１４ Aryl group, 5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -O-C ３－２０ Cycloalkyl group, -O-3 to 20-membered heterocyclyl group, -O-C ６－１４ Aryl group, -O-5 or 6-membered monocyclic heteroaryl group, -O-8 to 10-membered bicyclic heteroaryl group, -C≡C-C ３－２０ Cycloalkyl group, -C≡C-3 to 20-membered heterocyclyl group, -C≡C-C ６－１４ Aryl group, -C≡C-5 or 6-membered monocyclic heteroaryl group, -C≡C-8 to 10-membered bicyclic heteroaryl group, -C≡C-C １－４ Alkyl-C ３－２０ Cycloalkyl group, -C≡C-C １－４ Alkyl-3 to 20-membered heterocyclyl group, -C≡C-C １－４ Alkyl-C ６－１４ Aryl group, -C≡C-C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, -C≡C-C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -C １－４ Alkyl-hydroxyl group, -C １－４ Alkyl-cyano group, -C １－４ Alkyl-C １－６ Alkyl alkyl group, -C １－４ Alkyl-C １－６ Alkoxy group, -C １－４ Alkyl-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-O-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-3 to 20-membered heterocyclyl group, -C １－４ Alkyl-O-3 to 20-membered heterocyclyl group, -C １－４ Alkyl-C ６－１４ Aryl group, -C １－４ Alkyl-O-C ６－１４ Aryl group, -C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -C １－４ Alkyl-O-8 to 10-membered bicyclic heteroaryl group, -O-C １－４ Alkyl-hydroxyl group, -O-C １－４ Alkyl-cyano group, -O-C １－４ Alkyl-C １－６ Alkyl alkyl group, -O-C １－４ Alkyl-C １－６ Alkoxy group, -O-C １－４ Alkyl-C ３－２０ Cycloalkyl groups, -O-C １－４ Alkyl-O-C ３－２０ Cycloalkyl groups, -O-C １－４ Alkyl-3 to 20-membered heterocyclyl group, -O-C １－４ Alkyl-O-3 to 20-membered heterocyclyl group, -O-C １－４ Alkyl-C ６－１４ Aryl group, -O-C １－４ Alkyl-O-C ６－１４ Aryl group, -O-C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, -O-C １－４ Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -O-C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -O-C １－４ Alkyl-O-8 to 10-membered bicyclic heteroaryl group, -S (=O) ２ -C １－６ Alkyl alkyl group, -S (=O) ２ -C ３－２０ Cycloalkyl group, -S (=O) ２ -3 to 20-membered heterocyclyl group, -C(=O)O-C １－６ Alkyl alkyl group, -C(=O)O-C ３－２０ Cycloalkyl group, -C(=O)-C １－６ Alkyl alkyl group, -C(=O)-C ３－２０ Cycloalkyl group, -C(=O)-C ６－１４ Aryl group, -NR ａ１ R ｂ１ , -C(=O)-NR ａ１ R ｂ１ , -C(=O)-NR ｄ１ -C １－４ Alkyl-R ｃ１ , -OR ｃ１ , -C １－４ Alkyl-S (=O) ２ -C １－６ Alkyl alkyl group, -C １－４ Alkyl-S (=O) ２ -C ３－２０ Cycloalkyl group, -C １－４ Alkyl-S (=O) ２ -3 to 20-membered heterocyclyl group, -C １－４ Alkyl-C(=O)O-C １－６ Alkyl alkyl group, -C １－４ Alkyl-C(=O)O-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-C(=O)-C １－６ Alkyl alkyl group, -C １－４ Alkyl-C(=O)-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-C(=O)-C ６－１４ Aryl group, -C(=O)-5 or 6-membered monocyclic heteroaryl group, -C(=O)-8 to 10-membered bicyclic heteroaryl group, -C(=O)-C １－６ Alkyl-C ３－２０ Cycloalkyl group, -C(=O)-C １－６ Alkyl-3 to 20-membered heterocyclyl group, -C(=O)-C １－６ Alkyl-C ６－１４ Aryl group, -C(=O)-C １－６ Alkyl-5 or 6-membered monocyclic heteroaryl group, -C(=O)-C １－６ Alkyl-8 to 10-membered bicyclic heteroaryl group, -C １－４ Alkyl-NR ａ１ R ｂ１ , -C １－４ Alkyl-C(=O)-NR ａ１ R ｂ１ , -C≡C-C(=O)-NR ａ１ R ｂ１ , -C≡C-C １－４ Alkyl-C(=O)-NR ａ１ R ｂ１ , -C １－４ Alkyl-OR ｃ１ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ , -P(=O)-(C １－６ Alkyl) ２ , -C １－４ Alkyl-NR ｄ１ -C(=O)-R ｃ１ , -C １－４ Alkyl-NR ｄ１ -C(=O)-NR ａ１ R ｂ１ , -C １－４ Alkyl-NR ｄ１ -S (=O) ２ -R ｃ１ , -C １－４ Alkyl-S (=O) ２ -NR ａ１ R ｂ１ , -C １－４ Alkyl-NR ｄ１ -S (=O) ２ -NR ａ１ R ｂ１ , -NR ｄ１ -C(=O)-R ｃ１ , -NR ｄ１ -C (=O) -C １－４ Alkyl-R ｃ１ , -NR ｄ１ -C(=O)-NR ａ１ R ｂ１ , -NR ｄ１ -S (=O) ２ -R ｃ１ , -S (=O) ２ -NR ａ１ R ｂ１ , -NR ｄ１ -S (=O) ２ -NR ａ１ R ｂ１ and -P(=O)-(C １－６ Alkyl) ２ Selected from the group consisting of the above C １－６ alkyl group, the C １－６ Alkoxy group, the C ２－６ Alkenyl group, the C ２－６ Each alkynyl group is independently and optionally substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the C ３－２０ Cycloalkyl group, the 3-20 membered heterocyclyl group, the C ６－１４ The aryl group, the 5 or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently and arbitrarily substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R ａ１ , R ｂ１ H and C are independent of each other. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, -C １－４ Alkyl-hydroxyl group, -C １－４ Alkyl-cyano group, -C １－４ Alkyl-halogenated C １－６ Alkyl alkyl group, -C １－４ Alkyl-deuterated C １－６ Alkyl alkyl group, -C １－４ Alkyl-C １－６ Alkoxy group, -C １－４ Alkyl-halogenated C １－６ Alkoxy group, -C １－４ Alkyl-deuterated C １－６ Alkoxy group, C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-O-C ３－６ Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C １－４ Alkyl-3 to 6-membered monocyclic heterocyclyl group, -C １－４ Alkyl-O-3 to 6-membered monocyclic heterocyclyl group, phenyl group, -C １－４ Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -S (=O) ２ -C １－６ Alkyl alkyl group, -S (=O) ２ -C ３－６ Monocyclic cycloalkyl group, -S (=O) ２ -3- to 6-membered monocyclic heterocyclyl group, -C １－４ Alkyl-S (=O) ２ -C １－６ Alkyl alkyl group, -C １－４ Alkyl-S (=O) ２ -C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-S (=O) ２ -3- to 6-membered monocyclic heterocyclyl group, -C(=O)-C １－６ Alkyl alkyl group, -C(=O)-C ３－６ The monocyclic cycloalkyl group and the -C(=O)-3 to 6-membered monocyclic heterocyclyl group, of which the C ３－６ The monocyclic cycloalkyl group, the 3-6 membered monocyclic heterocyclyl group, the phenyl group, the 5 or 6 membered monocyclic heteroaryl group, and the 8-10 membered bicyclic heteroaryl group may optionally be a halogen, hydroxyl group, carboxyl group, nitro group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ and -P(=O)-(C １－６ Alkyl) ２ Substituted with one or two groups selected from the group consisting of, or Each R ａ１ and R ｂ１ These, together with the nitrogen atom linked to them, form a 3-20 membered heterocyclyl group, and each of these 3-20 membered heterocyclyl groups can independently and arbitrarily be a halogen, hydroxyl group, carboxyl group, nitro group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ and -P(=O)-(C １－６ Alkyl) ２ Substituted with one or two groups selected from the group consisting of, In each of the above groups, each R ｄ１ H and C are independent of each other. １－６ Alkyl or deuterated C １－６ It is an alkyl group, In each of the above groups, each R ｃ１ H and C are independent of each other. １－６ Alkyl alkyl group, -C １－４ Alkyl-hydroxyl group, -C １－４ Alkyl-NR ａ１ R ｂ１ , halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -C １－４ Alkyl-halogenated C １－６ Alkyl alkyl group, -C １－４ Alkyl-deuterated C １－６ Alkyl alkyl group, -C １－４ Alkyl-C １－６ Alkoxy group, -C １－４ Alkyl-halogenated C １－６ Alkoxy group, -C １－４ Alkyl-deuterated C １－６ Alkoxy group, C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-O-C ３－６ Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C １－４ Alkyl-3 to 6-membered monocyclic heterocyclyl group, -C １－４ Alkyl-O-3 to 6-membered monocyclic heterocyclyl group, phenyl group, -C １－４ Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, or -C １－４ The alkyl-8 to 10-membered bicyclic heteroaryl group, and the C ３－６ The monocyclic cycloalkyl group, the 3-6 membered monocyclic heterocyclyl group, the phenyl group, the 5 or 6 membered monocyclic heteroaryl group, and the 8-10 membered bicyclic heteroaryl group may optionally be a halogen, hydroxyl group, carboxyl group, nitro group, or C １－６ Alkyl alkyl group, C ３－６ Monocyclic cycloalkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ and -P(=O)-(C １－６ Alkyl) ２ Substituted with one or two groups selected from the group consisting of, In each of the above groups, each S2 group group is independently deuterium, oxo (=O), thio (=S), =CR ｅ R ｆ , = NR ｅ , halogen, hydroxyl group, carboxyl group, nitro group, C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -(C=O)-NHC １－６ Alkyl alkyl group, -(C=O)-N(C １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ , -P(=O)-(C １－６ Alkyl) ２ -(C=O)C １－６ Alkyl alkyl group, -SF ５ and -C １－４ Selected from the group consisting of alkyl-hydroxyl groups, In each of the above groups, -C １－４ Alkyl- is unsubstituted, or -C １－４ Alkyl- The 1, 2, 3, or 4 hydrogen atoms on the alkyl group are each independently a halogen, cyano group, hydroxyl group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, -CH ２ -Hydroxy group, -CH ２ -Cyano group, phenyl group, C ３－６ Substituted with a group selected from monocyclic cycloalkyl groups, or C １－４ Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously -(CH ２ ) ｊ It is substituted with - to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or C １－４ Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously = CR ｅ R ｆ Replaced by, In each of the above groups, R ｅ These are H, halogen, and C, respectively, independently. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl or deuterated C １－６ It is an alkyl group, In each of the above groups, R ｆ These are H, halogen, and C, respectively, independently. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl or deuterated C １－６ It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3-8 membered heterocyclyl group, 3-10 membered heterocyclyl group, or 3-8 membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and the C １－６ One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7-12 membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3-20 membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6 membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8-10 membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. The heteroatoms are selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3-6 member monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5-15 member tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6-12 member heteroaryl group condensed cycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6-12 member heteroaryl group condensed heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. If the ring atom is a sulfur atom, the sulfur atom may be optionally oxo and =NR ｅ Substituted by one or two groups selected from R ｅ The definition is the same as above, If the ring atom is a phosphorus atom, the phosphorus atom can be optionally oxo and =NR ｅ Substituted by one or two groups selected from R ｅ The definition is the same as above. Compounds, or their stable deuterated derivatives, stereoisomers, or their pharmaceutically acceptable salts, solvates, or prodrugs.

2. The group consisting of is selected, and the definition of X is the same as above. R ３ C is hydrogen, substituted or unsubstituted. １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Heteroalkyl groups, substituted or unsubstituted C ２－６ Alkenyl group, substituted or unsubstituted C ２－６ Alkynyl group, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ The group is an aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8 to 10-membered bicyclic heteroaryl group. The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

3. Selected from, the definition of X is the same as above, R ３ C is hydrogen, substituted or unsubstituted. １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Heteroalkyl groups, substituted or unsubstituted C ２－６ Alkenyl group, substituted or unsubstituted C ２－６ Alkynyl group, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ The group is an aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8 to 10-membered bicyclic heteroaryl group, R １３ C is hydrogen, halogen, substituted or unsubstituted １－６ Alkoxy group, substituted or unsubstituted C １－６ It is an alkyl group, or R １３ and R ３ These, together with atoms linked to them, form a substituted or unsubstituted nitrogen-containing 3- to 8-membered monocyclic heterocyclyl group or a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, wherein one ring atom of the nitrogen-containing 3- to 8-membered monocyclic heterocyclyl group is a nitrogen atom, and one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

4. The compounds of formula (I) are as shown by formulas (A1), (A2), (A3), (A4), (A5), (A6), (B1), (B2), (B3), or (B4), Eventually, R ３ C is hydrogen, substituted or unsubstituted. １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Heteroalkyl groups, substituted or unsubstituted C ２－６ Alkenyl group, substituted or unsubstituted C ２－６ Alkynyl group, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8 to 10-membered bicyclic heteroaryl group, R １３ C is hydrogen, halogen, substituted or unsubstituted １－６ Alkyl alkyl group, substituted or unsubstituted C １－６ It is an alkoxy group, or R １３ and R ３ Together with the atoms linked to them, they form substituted or unsubstituted nitrogen-containing 3-8 membered monocyclic heterocycline groups. R ４２ C is hydrogen, halogen, substituted or unsubstituted １－６ It is an alkyl group, R ４３ C is hydrogen, halogen, substituted or unsubstituted １－６ It is an alkyl group, or R ４２ and R ４３ These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. ３－６ Forming a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclyl group, L １ ha-N(R ００ )C(=O)-,-N(R ００ )C(=O)-O-,-C １－４ Alkyl-N(R) ００ )C(=O)-, -C(=O)N(R ００ )-C １－４ Alkyl-, -C １－４ Alkyl-N(R) ００ ) C (= S) -, substituted or unsubstituted C １－６ Alkyl alkyl groups, -substituted or unsubstituted C １－６ Alkyl-O-,-substituted or unsubstituted C ２－６ Alkenyl-O-substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ Aryl group, substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl group, -L ２ - Substituted or unsubstituted C ６－１０ Aryl group, -L ２ - Substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group or -L ２ - A substituted or unsubstituted 3- to 8-membered heterocyclyl group, L ２ -O-, -C １－４ Alkyl-, -N(R) ００ )-, -C(=O)-, -CR ０９ =CR １０ -, -N(R ００ )C(=O)- or -N(R ００ ) C (= S) -, R ００ is hydrogen or C １－６ It is an alkyl group, R １ is hydrogen, deuterium, halogen, hydroxyl group, C １－６ Alkyl alkyl group, substituted or unsubstituted C １－６ It is a heteroalkyl group, R ２ is hydrogen, deuterium, halogen, C １－６ Alkyl alkyl group, substituted or unsubstituted C １－６ It is a heteroalkyl group, R ４ａ is a substituted or unsubstituted C １－６ Alkyl alkyl groups, substituted or unsubstituted C ３－６ A cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclyl group, R ５ Ha-NR ０１ R ０２ or -C ２－４ Alkinyl-C １－４ Alkyl-NR ０１ R ０２ And, R ０１ , R ０２ Each is independently hydrogen, substituted or unsubstituted C １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Alkoxy group, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted C ２－６ Alkenyl group, substituted or unsubstituted C ２－６ Selected from alkynyl groups, or R ０１ , R ０２ These, together with the nitrogen atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups. R ０９ C is hydrogen, deuterium, halogen, or substituted or unsubstituted C １－６ It is an alkyl group, and the substitution means that it is substituted with one or more (for example, 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. R １０ C is hydrogen, deuterium, halogen, or substituted or unsubstituted C １－６ It is an alkyl group, and the substitution means that it is substituted with one or more (for example, 1, 2, 3, or 4) groups selected from the group consisting of deuterium and halogens. R ６ is a substituted or unsubstituted C １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Heteroalkyl groups, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8 to 10-membered bicyclic heteroaryl group, In each of the above groups, the substitution means that each group is independently substituted with one, two, three, four, five, or six groups selected from group S1, and each of the groups in group S1 is independently -SF ５ Deuterium, oxo (=O), thio (=S), =CR ｅ R ｆ , = NR ｅ , halogen, cyano group, hydroxyl group, carboxyl group, nitro group, C １－６ Alkyl alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Alkoxy group, C ３－２０ Cycloalkyl group, 3-20 membered heterocyclyl group, C ６－１４ Aryl group, 5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -O-C ３－２０ Cycloalkyl group, -O-3 to 20-membered heterocyclyl group, -O-C ６－１４ Aryl group, -O-5 or 6-membered monocyclic heteroaryl group, -O-8 to 10-membered bicyclic heteroaryl group, -C≡C-C ３－２０ Cycloalkyl group, -C≡C-3 to 20-membered heterocyclyl group, -C≡C-C ６－１４ Aryl group, -C≡C-5 or 6-membered monocyclic heteroaryl group, -C≡C-8 to 10-membered bicyclic heteroaryl group, -C≡C-C １－４ Alkyl-C ３－２０ Cycloalkyl group, -C≡C-C １－４ Alkyl-3 to 20-membered heterocyclyl group, -C≡C-C １－４ Alkyl-C ６－１４ Aryl group, -C≡C-C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, -C≡C-C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -C １－４ Alkyl-hydroxyl group, -C １－４ Alkyl-cyano group, -C １－４ Alkyl-C １－６ Alkyl alkyl group, -C １－４ Alkyl-C １－６ Alkoxy group, -C １－４ Alkyl-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-O-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-3 to 20-membered heterocyclyl group, -C １－４ Alkyl-O-3 to 20-membered heterocyclyl group, -C １－４ Alkyl-C ６－１４ Aryl group, -C １－４ Alkyl-O-C ６－１４ Aryl group, -C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -C １－４ Alkyl-O-8 to 10-membered bicyclic heteroaryl group, -O-C １－４ Alkyl-hydroxy group, -O-C １－４ Alkyl-cyano group, -O-C １－４ Alkyl-C １－６ Alkyl group, -O-C １－４ Alkyl-C １－６ Alkoxy group, -O-C １－４ Alkyl-C ３－２０ Cycloalkyl group, -O-C １－４ Alkyl-O-C ３－２０ Cycloalkyl group, -O-C １－４ Alkyl-3 to 20-membered heterocyclyl group, -O-C １－４ Alkyl-O-3 to 20-membered heterocyclyl group, -O-C １－４ Alkyl-C ６－１４ Aryl group, -O-C １－４ Alkyl-O-C ６－１４ Aryl group, -O-C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, -O-C １－４ Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -O-C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -O-C １－４ Alkyl-O-8 to 10-membered bicyclic heteroaryl group, -S(=O) ２ -C １－６ Alkyl group, -S(=O) ２ -C ３－２０ Cycloalkyl group, -S(=O) ２ -3 to 20-membered heterocyclyl group, -C(=O)O-C １－６ Alkyl alkyl group, -C(=O)O-C ３－２０ Cycloalkyl group, -C(=O)-C １－６ Alkyl alkyl group, -C(=O)-C ３－２０ Cycloalkyl group, -C(=O)-C ６－１４ Aryl group, -NR ａ１ R ｂ１ , -C(=O)-NR ａ１ R ｂ１ , -C(=O)-NR ｄ１ -C １－４ Alkyl-R ｃ１ , -OR ｃ１ , -C １－４ Alkyl-S (=O) ２ -C １－６ Alkyl alkyl group, -C １－４ Alkyl-S (=O) ２ -C ３－２０ Cycloalkyl group, -C １－４ Alkyl-S (=O) ２ -3 to 20-membered heterocyclyl group, -C １－４ Alkyl-C(=O)O-C １－６ Alkyl alkyl group, -C １－４ Alkyl-C(=O)O-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-C(=O)-C １－６ Alkyl alkyl group, -C １－４ Alkyl-C(=O)-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-C(=O)-C ６－１４ Aryl group, -C(=O)-5 or 6-membered monocyclic heteroaryl group, -C(=O)-8 to 10-membered bicyclic heteroaryl group, -C(=O)-C １－６ Alkyl-C ３－２０ Cycloalkyl group, -C(=O)-C １－６ Alkyl-3 to 20-membered heterocyclyl group, -C(=O)-C １－６ Alkyl-C ６－１４ Aryl group, -C(=O)-C １－６ Alkyl-5 or 6-membered monocyclic heteroaryl group, -C(=O)-C １－６ Alkyl-8 to 10-membered bicyclic heteroaryl group, -C １－４ Alkyl-NR ａ１ R ｂ１ , -C １－４ alkyl-C(=O)-NR ａ１ R ｂ１ , -C≡C-C(=O)-NR ａ１ R ｂ１ , -C≡C-C １－４ alkyl-C(=O)-NR ａ１ R ｂ１ , -C １－４ alkyl-OR ｃ１ , -C １－４ alkyl-P(=O)-(C １－６ alkyl) ２ , -P(=O)-(C １－６ alkyl) ２ , -C １－４ alkyl-NR ｄ１ -C(=O)-R ｃ１ , -C １－４ alkyl-NR ｄ１ -C(=O)-NR ａ１ R ｂ１ , -C １－４ alkyl-NR ｄ１ -S(=O) ２ -R ｃ１ , -C １－４ alkyl-S(=O) ２ -NR ａ１ R ｂ１ , -C １－４ alkyl-NR ｄ１ -S(=O) ２ -NR ａ１ R ｂ１ , -NR ｄ１ -C(=O)-R ｃ１ , -NR ｄ１ -C(=O)-C １－４ alkyl-R ｃ１ , -NR ｄ１ -C(=O)-NR ａ１ R ｂ１ , -NR ｄ１ -S(=O) ２ -R ｃ１ , -S(=O) ２ -NR ａ１ R ｂ１ , -NR ｄ１ -S(=O) ２ -NR ａ１ R ｂ１ and -P(=O)-(C １－６ Alkyl) ２ Selected from the group consisting of the above C １－６ alkyl group, the C １－６ Alkoxy group, the C ２－６ Alkenyl group, the C ２－６ Each alkynyl group is independently and optionally substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the C ３－２０ Cycloalkyl group, the 3-20 membered heterocyclyl group, the C ６－１４ The aryl group, the 5 or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently and arbitrarily substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R ａ１ , R ｂ１ H and C are independent of each other. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, -C １－４ Alkyl-hydroxyl group, -C １－４ Alkyl-cyano group, -C １－４ Alkyl-halogenated C １－６ Alkyl alkyl group, -C １－４ Alkyl-deuterated C １－６ Alkyl alkyl group, -C １－４ Alkyl-C １－６ Alkoxy group, -C １－４ Alkyl-halogenated C １－６ Alkoxy group, -C １－４ Alkyl-deuterated C １－６ Alkoxy group, C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-O-C ３－６ Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C １－４ Alkyl-3 to 6-membered monocyclic heterocyclyl group, -C １－４ Alkyl-O-3 to 6-membered monocyclic heterocyclyl group, phenyl group, -C １－４ Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -S (=O) ２ -C １－６ Alkyl alkyl group, -S (=O) ２ -C ３－６ Monocyclic cycloalkyl group, -S (=O) ２ -3- to 6-membered monocyclic heterocyclyl group, -C １－４ Alkyl-S (=O) ２ -C １－６ Alkyl alkyl group, -C １－４ Alkyl-S (=O) ２ -C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-S (=O) ２ -3- to 6-membered monocyclic heterocyclyl group, -C(=O)-C １－６ Alkyl alkyl group, -C(=O)-C ３－６ It is a monocyclic cycloalkyl group or a -C(=O)-3 to 6-membered monocyclic heterocyclyl group, of which the C ３－６ The monocyclic cycloalkyl group, the 3-6 membered monocyclic heterocyclyl group, the phenyl group, the 5 or 6 membered monocyclic heteroaryl group, and the 8-10 membered bicyclic heteroaryl group may optionally be a halogen, hydroxyl group, carboxyl group, nitro group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ and -P(=O)-(C １－６ Alkyl) ２ Substituted with one or two groups selected from the group consisting of, or Each R ａ１ and R ｂ１ These, together with the nitrogen atom linked to them, form a 3-20 membered heterocyclyl group, and each of these 3-20 membered heterocyclyl groups can independently and arbitrarily be a halogen, hydroxyl group, carboxyl group, nitro group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ and -P(=O)-(C １－６ Alkyl) ２ Substituted with one or two groups selected from the group consisting of, In each of the above groups, each R ｄ１ H and C are independent of each other. １－６ Alkyl or deuterated C １－６ It is an alkyl group, In each of the above groups, each R ｃ１ H and C are independent of each other. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -C １－４ Alkyl-halogenated C １－６ Alkyl alkyl group, -C １－４ Alkyl-deuterated C １－６ Alkyl alkyl group, -C １－４ Alkyl-C １－６ Alkoxy group, -C １－４ Alkyl-halogenated C １－６ Alkoxy group, -C １－４ Alkyl-deuterated C １－６ Alkoxy group, C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-O-C ３－６ Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C １－４ Alkyl-3 to 6-membered monocyclic heterocyclyl group, -C １－４ Alkyl-O-3 to 6-membered monocyclic heterocyclyl group, phenyl group, -C １－４ Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, or -C １－４ The alkyl-8 to 10-membered bicyclic heteroaryl group, and the C ３－６ The monocyclic cycloalkyl group, the 3-6 membered monocyclic heterocyclyl group, the phenyl group, the 5 or 6 membered monocyclic heteroaryl group, and the 8-10 membered bicyclic heteroaryl group may optionally be a halogen, hydroxyl group, carboxyl group, nitro group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ and -P(=O)-(C １－６ Alkyl) ２ Substituted with one or two groups selected from the group consisting of, In each of the above groups, each S2 group group is independently deuterium, oxo (=O), thio (=S), =CR ｅ R ｆ , = NR ｅ , halogen, hydroxyl group, carboxyl group, nitro group, C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -(C=O)-NHC １－６ Alkyl alkyl group, -(C=O)-N(C １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ , -P(=O)-(C １－６ Alkyl) ２ -(C=O)C １－６ Alkyl and -SF ５ Selected from the group consisting of, In each of the above groups, -C １－４ Alkyl- is unsubstituted, or -C １－４ Alkyl- The 1, 2, 3, or 4 hydrogen atoms on the alkyl group are each independently a halogen, cyano group, hydroxyl group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, -CH ２ -Hydroxy group, -CH ２ - Substituted with a group selected from cyano groups, phenyl groups, or C １－４ Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously -(CH ２ ) ｊ It is substituted with - to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or C １－４ Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously = CR ｅ R ｆ Replaced by, In each of the above groups, R ｅ These are H, halogen, and C, respectively, independently. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl or deuterated C １－６ It is an alkyl group, In each of the above groups, R ｆ These are H, halogen, and C, respectively, independently. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl or deuterated C １－６ It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3-8 membered heterocyclyl group, 3-10 membered heterocyclyl group, or 3-8 membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and the C １－６ One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7-12 membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3-20 membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; and one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6 membered monocyclic heteroaryl group The atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8-10 membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3-6 membered monocyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5-15 membered tricyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. If the ring atom is a sulfur atom, the sulfur atom may be optionally oxo and =NR ｅ Substituted by one or two groups selected from R ｅ The definition is the same as above, If the ring atom is a phosphorus atom, the phosphorus atom can be optionally oxo and =NR ｅ Substituted by one or two groups selected from R ｅ The definition is the same as above. The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

5. The compound of formula (I) is as shown in formula (C1), (C1) R ４２ C is hydrogen, halogen, substituted or unsubstituted １－６ It is an alkyl group, R ４３ C is hydrogen, halogen, substituted or unsubstituted １－６ It is an alkyl group, or R ４２ and R ４３ These are substituted or unsubstituted C atoms together with the carbon atoms they are linked to. ３－６ Forming a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclyl group, L １ ha-N(R ００ )C(=O)-O-,-C １－４ Alkyl-N(R) ００ )C(=O)-, -C(=O)N(R ００ )-C １－４ Alkyl-, -C １－４ Alkyl-N(R) ００ ) C (=S) -, - substitution or unsubstituted C １－６ Alkyl-O- or -- substituted or unsubstituted C ２－６ It is an alkenyl-O-, R ００ is hydrogen or C １－６ It is an alkyl group, R １ is hydrogen, deuterium, halogen, hydroxyl group, C １－６ Alkyl alkyl group, substituted or unsubstituted C １－６ It is a heteroalkyl group, R ２ is hydrogen, deuterium, halogen, C １－６ Alkyl alkyl group, substituted or unsubstituted C １－６ It is a heteroalkyl group, R ３ C is hydrogen, substituted or unsubstituted. １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Heteroalkyl groups, substituted or unsubstituted C ２－６ Alkenyl group, substituted or unsubstituted C ２－６ Alkynyl group, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8 to 10-membered bicyclic heteroaryl group, R ４ａ is a substituted or unsubstituted C １－６ Alkyl alkyl groups, substituted or unsubstituted C ３－６ A cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclyl group, R ５ Ha-NR ０１ R ０２ or -C ２－４ Alkinyl-C １－４ Alkyl-NR ０１ R ０２ And, R ０１ , R ０２ Each is independently hydrogen, substituted or unsubstituted C １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Alkoxy group, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted C ２－６ Alkenyl group, substituted or unsubstituted C ２－６ Selected from alkynyl groups, or R ０１ , R ０２ These, together with the nitrogen atoms linked to them, form substituted or unsubstituted 5-15 member tricyclic heterocyclyl groups, substituted or unsubstituted 7-12 member bicyclic heterocyclyl groups, and substituted or unsubstituted 3-8 member monocyclic heterocyclyl groups. R ６ is a substituted or unsubstituted C １－６ Alkyl alkyl groups, substituted or unsubstituted C １－６ Heteroalkyl groups, substituted or unsubstituted C ３－６ Cycloalkyl groups, substituted or unsubstituted 3- to 8-membered heterocyclyl groups, substituted or unsubstituted C ６－１０ An aryl group, a substituted or unsubstituted 5 or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8 to 10-membered bicyclic heteroaryl group, In each of the above groups, the substitution means that each group is independently substituted with one, two, three, four, five, or six groups selected from group S1, and each of the groups in group S1 is independently -SF ５ Deuterium, oxo (=O), thio (=S), =CR ｅ R ｆ , = NR ｅ , halogen, cyano group, hydroxyl group, carboxyl group, nitro group, C １－６ Alkyl alkyl group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, C １－６ Alkoxy group, C ３－２０ Cycloalkyl group, 3-20 membered heterocyclyl group, C ６－１４ Aryl group, 5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -O-C ３－２０ Cycloalkyl group, -O-3 to 20-membered heterocyclyl group, -O-C ６－１４ Aryl group, -O-5 or 6-membered monocyclic heteroaryl group, -O-8 to 10-membered bicyclic heteroaryl group, -C≡C-C ３－２０ Cycloalkyl group, -C≡C-3 to 20-membered heterocyclyl group, -C≡C-C ６－１４ Aryl group, -C≡C-5 or 6-membered monocyclic heteroaryl group, -C≡C-8 to 10-membered bicyclic heteroaryl group, -C≡C-C １－４ Alkyl-C ３－２０ Cycloalkyl group, -C≡C-C １－４ Alkyl-3 to 20-membered heterocyclyl group, -C≡C-C １－４ Alkyl-C ６－１４ Aryl group, -C≡C-C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, -C≡C-C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -C １－４ Alkyl-hydroxyl group, -C １－４ Alkyl-cyano group, -C １－４ Alkyl-C １－６ Alkyl alkyl group, -C １－４ Alkyl-C １－６ Alkoxy group, -C １－４ Alkyl-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-O-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-3 to 20-membered heterocyclyl group, -C １－４ Alkyl-O-3 to 20-membered heterocyclyl group, -C １－４ Alkyl-C ６－１４ Aryl group, -C １－４ Alkyl-O-C ６－１４ Aryl group, -C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -C １－４ Alkyl-O-8 to 10-membered bicyclic heteroaryl group, -O-C １－４ Alkyl-hydroxyl group, -O-C １－４ Alkyl-cyano group, -O-C １－４ Alkyl-C １－６ Alkyl alkyl group, -O-C １－４ Alkyl-C １－６ Alkoxy group, -O-C １－４ Alkyl-C ３－２０ Cycloalkyl groups, -O-C １－４ Alkyl-O-C ３－２０ Cycloalkyl groups, -O-C １－４ Alkyl-3 to 20-membered heterocyclyl group, -O-C １－４ Alkyl-O-3 to 20-membered heterocyclyl group, -O-C １－４ Alkyl-C ６－１４ Aryl group, -O-C １－４ Alkyl-O-C ６－１４ Aryl group, -O-C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, -O-C １－４ Alkyl-O-5 or 6-membered monocyclic heteroaryl group, -O-C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -O-C １－４ Alkyl-O-8 to 10-membered bicyclic heteroaryl group, -S (=O) ２ -C １－６ Alkyl alkyl group, -S (=O) ２ -C ３－２０ Cycloalkyl group, -S (=O) ２ -3 to 20-membered heterocyclyl group, -C(=O)O-C １－６ Alkyl alkyl group, -C(=O)O-C ３－２０ Cycloalkyl group, -C(=O)-C １－６ Alkyl alkyl group, -C(=O)-C ３－２０ Cycloalkyl group, -C(=O)-C ６－１４ Aryl group, -NR ａ１ R ｂ１ , -C(=O)-NR ａ１ R ｂ１ , -C(=O)-NR ｄ１ -C １－４ Alkyl-R ｃ１ , -OR ｃ１ , -C １－４ Alkyl-S (=O) ２ -C １－６ Alkyl alkyl group, -C １－４ Alkyl-S (=O) ２ -C ３－２０ Cycloalkyl group, -C １－４ Alkyl-S (=O) ２ -3 to 20-membered heterocyclyl group, -C １－４ Alkyl-C(=O)O-C １－６ Alkyl alkyl group, -C １－４ Alkyl-C(=O)O-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-C(=O)-C １－６ Alkyl alkyl group, -C １－４ Alkyl-C(=O)-C ３－２０ Cycloalkyl group, -C １－４ Alkyl-C(=O)-C ６－１４ Aryl group, -C(=O)-5 or 6-membered monocyclic heteroaryl group, -C(=O)-8 to 10-membered bicyclic heteroaryl group, -C(=O)-C １－６ Alkyl-C ３－２０ Cycloalkyl group, -C(=O)-C １－６ Alkyl-3 to 20-membered heterocyclyl group, -C(=O)-C １－６ Alkyl-C ６－１４ Aryl group, -C(=O)-C １－６ Alkyl-5 or 6-membered monocyclic heteroaryl group, -C(=O)-C １－６ Alkyl-8 to 10-membered bicyclic heteroaryl group, -C １－４ Alkyl-NR ａ１ R ｂ１ , -C １－４ Alkyl-C(=O)-NR ａ１ R ｂ１ , -C≡C-C(=O)-NR ａ１ R ｂ１ , -C≡C-C １－４ Alkyl-C(=O)-NR ａ１ R ｂ１ , -C １－４ Alkyl-OR ｃ１ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ , -P(=O)-(C １－６ Alkyl) ２ , -C １－４ Alkyl-NR ｄ１ -C(=O)-R ｃ１ , -C １－４ Alkyl-NR ｄ１ -C(=O)-NR ａ１ R ｂ１ , -C １－４ Alkyl-NR ｄ１ -S (=O) ２ -R ｃ１ , -C １－４ Alkyl-S (=O) ２ -NR ａ１ R ｂ１ , -C １－４ Alkyl-NR ｄ１ -S (=O) ２ -NR ａ１ R ｂ１ , -NR ｄ１ -C(=O)-R ｃ１ , -NR ｄ１ -C (=O) -C １－４ Alkyl-R ｃ１ , -NR ｄ１ -C(=O)-NR ａ１ R ｂ１ , -NR ｄ１ -S (=O) ２ -R ｃ１ , -S (=O) ２ -NR ａ１ R ｂ１ , -NR ｄ１ -S (=O) ２ -NR ａ１ R ｂ１ and -P(=O)-(C １－６ Alkyl) ２ Selected from the group consisting of the above C １－６ alkyl group, the C １－６ Alkoxy group, the C ２－６ Alkenyl group, the C ２－６ Each alkynyl group is independently and optionally substituted with one, two, or three groups selected from halogen, deuterium, cyano, or hydroxyl groups, and the C ３－２０ Cycloalkyl group, the 3-20 membered heterocyclyl group, the C ６－１４ The aryl group, the 5 or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently and arbitrarily substituted with 1, 2, 3, or 4 groups selected from the S2 group. In each of the above groups, each R ａ１ , R ｂ１ H and C are independent of each other. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, -C １－４ Alkyl-hydroxyl group, -C １－４ Alkyl-cyano group, -C １－４ Alkyl-halogenated C １－６ Alkyl alkyl group, -C １－４ Alkyl-deuterated C １－６ Alkyl alkyl group, -C １－４ Alkyl-C １－６ Alkoxy group, -C １－４ Alkyl-halogenated C １－６ Alkoxy group, -C １－４ Alkyl-deuterated C １－６ Alkoxy group, C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-O-C ３－６ Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C １－４ Alkyl-3 to 6-membered monocyclic heterocyclyl group, -C １－４ Alkyl-O-3 to 6-membered monocyclic heterocyclyl group, phenyl group, -C １－４ Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, -C １－４ Alkyl-8 to 10-membered bicyclic heteroaryl group, -S (=O) ２ -C １－６ Alkyl alkyl group, -S (=O) ２ -C ３－６ Monocyclic cycloalkyl group, -S (=O) ２ -3- to 6-membered monocyclic heterocyclyl group, -C １－４ Alkyl-S (=O) ２ -C １－６ Alkyl alkyl group, -C １－４ Alkyl-S (=O) ２ -C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-S (=O) ２ -3- to 6-membered monocyclic heterocyclyl group, -C(=O)-C １－６ Alkyl alkyl group, -C(=O)-C ３－６ It is a monocyclic cycloalkyl group or a -C(=O)-3 to 6-membered monocyclic heterocyclyl group, of which the C ３－６ The monocyclic cycloalkyl group, the 3-6 membered monocyclic heterocyclyl group, the phenyl group, the 5 or 6 membered monocyclic heteroaryl group, and the 8-10 membered bicyclic heteroaryl group may optionally be a halogen, hydroxyl group, carboxyl group, nitro group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ and -P(=O)-(C １－６ Alkyl) ２ Substituted with one or two groups selected from the group consisting of, or Each R ａ１ and R ｂ１ These, together with the nitrogen atom linked to them, form a 3-20 membered heterocyclyl group, and each of these 3-20 membered heterocyclyl groups can independently and arbitrarily be a halogen, hydroxyl group, carboxyl group, nitro group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ and -P(=O)-(C １－６ Alkyl) ２ Substituted with one or two groups selected from the group consisting of, In each of the above groups, each R ｄ１ H and C are independent of each other. １－６ Alkyl or deuterated C １－６ It is an alkyl group, In each of the above groups, each R ｃ１ H and C are independent of each other. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -C １－４ Alkyl-halogenated C １－６ Alkyl alkyl group, -C １－４ Alkyl-deuterated C １－６ Alkyl alkyl group, -C １－４ Alkyl-C １－６ Alkoxy group, -C １－４ Alkyl-halogenated C １－６ Alkoxy group, -C １－４ Alkyl-deuterated C １－６ Alkoxy group, C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-C ３－６ Monocyclic cycloalkyl group, -C １－４ Alkyl-O-C ３－６ Monocyclic cycloalkyl groups, 3-6 membered monocyclic heterocyclyl groups, -C １－４ Alkyl-3 to 6-membered monocyclic heterocyclyl group, -C １－４ Alkyl-O-3 to 6-membered monocyclic heterocyclyl group, phenyl group, -C １－４ Alkylphenyl group, 5 or 6-membered monocyclic heteroaryl group, -C １－４ Alkyl-5 or 6-membered monocyclic heteroaryl group, 8-10-membered bicyclic heteroaryl group, or -C １－４ The alkyl-8 to 10-membered bicyclic heteroaryl group, and the C ３－６ The monocyclic cycloalkyl group, the 3-6 membered monocyclic heterocyclyl group, the phenyl group, the 5 or 6 membered monocyclic heteroaryl group, and the 8-10 membered bicyclic heteroaryl group may optionally be a halogen, hydroxyl group, carboxyl group, nitro group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ and -P(=O)-(C １－６ Alkyl) ２ Substituted with one or two groups selected from the group consisting of, In each of the above groups, each S2 group group is independently deuterium, oxo (=O), thio (=S), =CR ｅ R ｆ , = NR ｅ , halogen, hydroxyl group, carboxyl group, nitro group, C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, C １－６ Alkoxy group, halogenated C １－６ Alkoxy group, deuterated C １－６ Alkoxy group, -NH ２ , - NHC １－６ Alkyl alkyl, -N(C) １－６ Alkyl) ２ , -(C=O)-NHC １－６ Alkyl alkyl group, -(C=O)-N(C １－６ Alkyl) ２ , -C １－４ Alkyl-P(=O)-(C １－６ Alkyl) ２ , -P(=O)-(C １－６ Alkyl) ２ -(C=O)C １－６ Alkyl and -SF ５ Selected from the group consisting of, In each of the above groups, -C １－４ Alkyl- is unsubstituted, or -C １－４ Alkyl- The 1, 2, 3, or 4 hydrogen atoms on the alkyl group are each independently a halogen, cyano group, hydroxyl group, or C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group, -CH ２ -Hydroxy group, -CH ２ - Substituted with a group selected from cyano groups, phenyl groups, or C １－４ Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously -(CH ２ ) ｊ It is substituted with - to further form a cycloalkyl group, where j is 2, 3, 4, 5 or 6, or C １－４ Two hydrogen atoms bonded to the same carbon atom on an alkyl group simultaneously = CR ｅ R ｆ Replaced by, In each of the above groups, R ｅ These are H, halogen, and C, respectively, independently. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl or deuterated C １－６ It is an alkyl group, In each of the above groups, R ｆ These are H, halogen, and C, respectively, independently. １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl or deuterated C １－６ It is an alkyl group, In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3-8 membered heterocyclyl group, 3-10 membered heterocyclyl group, or 3-8 membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and the C １－６ One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7-12 membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3-20 membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; and one or more (e.g., 1, 2, 3, or 4) ring atoms of the 5 or 6 membered monocyclic heteroaryl group The atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8-10 membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3-6 membered monocyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus, and one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5-15 membered tricyclic heterocyclil group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. If the ring atom is a sulfur atom, the sulfur atom may be optionally oxo and =NR ｅ Substituted by one or two groups selected from R ｅ The definition is the same as above, If the ring atom is a phosphorus atom, the phosphorus atom can be optionally oxo and =NR ｅ Substituted by one or two groups selected from R ｅ The definition is the same as above. The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

6. R ４ａ Ha-C １－６ Alkyl-C １－６ It is an alkoxy group, The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

7. R ５ is hydrogen, Selected from, The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

8. R ３ is hydrogen, C １－６ Alkyl alkyl groups, halogenated C １－６ Alkyl alkyl groups, deuterated C １－６ Alkyl alkyl group or C ３－６ It is a cycloalkyl group. The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

9. R １ is hydrogen, R ２ It is hydrogen. The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

10. L １ teeth Selected from, The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

11. R ６ teeth Selected from, The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

12. The aforementioned compound is selected from Table A, Table B, or Table C. The compound described in claim 1, or a stable deuterated derivative thereof, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

13. A pharmaceutical composition comprising a compound according to any one of claims 1 to 12, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrag thereof, and a pharmaceutically acceptable carrier.

14. Use of a compound according to any one of claims 1 to 12, or a stable deuterated derivative, stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, or the pharmaceutical composition according to claim 13, in the manufacture of a drug for preventing and / or treating a disease or symptom related to RAS protein activity.

15. The use according to claim 14, wherein the disease or symptom associated with the RAS protein activity is cancer.

16. The use according to claim 15, wherein the cancer is pancreatic cancer, colorectal cancer, non-small cell lung cancer, acute myeloid leukemia, multiple myeloma, thyroid adenocarcinoma, myelodysplastic syndrome, squamous cell lung cancer, esophageal cancer, ovarian cancer, uterine cancer, malignant melanoma, bladder cancer, or head and neck cancer.

Images