A composition that provides an effective microbial inhibitory concentration of an antimicrobial compound.

Abstract

This disclosure relates to compositions and related apparatus that provide effective microbial inhibitory headspace concentrations of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof.

Description

[Technical Field]

[0001] [Cross-reference of related applications] This application claims the benefit and priority of U.S. Provisional Application No. 63 / 536,773, filed on 6 September 2023, the contents of which are incorporated herein by reference in their entirety for all purposes.

[0002] This technology relates to compositions and related apparatus that provide effective microbial inhibitory headspace concentrations of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof. [Overview of the Initiative] [Means for solving the problem]

[0003] In one aspect of the present technology, a composition is disclosed for providing an effective microbial inhibitory headspace concentration of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof, comprising allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof, a fragrance, and optionally an emulsifier. As those skilled in the art will understand from this disclosure and will readily implement based thereon, a specific effective microbial inhibitory headspace concentration for a particular component (i.e., allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof) may be provided by adjusting the amount of the component in the composition, taking into account variables such as (i) the size of the room, (ii) the type of delivery device, (iii) the release rate of the delivery device, and (iv) the size of the storage compartment of the delivery device.

[0004] In one aspect of the present technology, an apparatus is provided comprising a composition according to any embodiment disclosed herein, the apparatus configured to provide an effective microbial inhibitory headspace concentration of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof. The apparatus may be, for example, an air fragrance device and may be configured for use in various applications for delivering allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof into the atmosphere. [Modes for carrying out the invention]

[0005] The following terms are used throughout this specification as defined below. In this specification and the appended claims, singular articles such as “a,” “an,” and “the,” and similar demonstrative pronouns in the context describing elements (particularly in the context of the following claims) should be interpreted as encompassing both singular and plural, unless otherwise indicated herein or unless the context clearly contradicts this interpretation. Numerical ranges described herein are intended merely as a convenient way to refer individually to each individual value within that range, unless otherwise indicated herein, and each individual value is invoked herein as if it were individually described herein. All methods described herein may be implemented in any suitable order, unless otherwise indicated herein or unless the context clearly contradicts this interpretation. Any use of any examples or illustrative language provided herein (e.g., “such as”) is intended merely to better describe embodiments and, unless otherwise indicated, does not limit the scope of the claims. No language herein should be interpreted as indicating an element not claimed as essential.

[0006] Where used herein, “about” is to be understood by those skilled in the art and varies to some extent depending on the context in which it is used. Where there is a use of the term that is not clear to those skilled in the art even considering the context in which it is used, “about” means plus or minus 10% of the particular term. For example, “about 10% by weight” is understood to mean “9% to 11% by weight.” Where “about” precedes a term, it should be understood that the term is interpreted as disclosing both the “about” value of the term and the value of the term without the “about” modification. For example, “about 10% by weight” discloses “9% to 11% by weight” and “10% by weight.”

[0007] As used in this disclosure, the phrase "and / or" means any one of the listed components individually, or any combination of two or more of them. For example, "A, B, and / or C" means "A, B, C, A and B, A and C, B and C, or any combination of A, B and C."

[0008] Generally, references to specific elements such as hydrogen or H are intended to include all isotopes of that element. For example, if an R group is defined as containing hydrogen or H, it also includes deuterium and tritium. Therefore, tritium, C 14 , P 32 and S 35 Compounds containing radioactive isotopes such as those described herein fall within the scope of this technology. Procedures for inserting such labels into compounds of this technology will be readily apparent to those skilled in the art based on the disclosure herein.

[0009] Generally, "substituted" means that in an organic group (e.g., an alkyl group) as defined below, one or more bonds to a hydrogen atom are replaced by bonds to a non-hydrogen or non-carbon atom. Substituents also include groups in which one or more bonds to a carbon or hydrogen atom are replaced by one or more bonds to a heteroatom, including double or triple bonds. Thus, unless otherwise specified, substituents are substituted with one or more substituents. In some embodiments, substituents are substituted with one, two, three, four, five, or six substituents. Examples of substituents include halogens (i.e., F, Cl, Br, and I), hydroxyl, alkoxy, alkenoxy, aryloxy, aralkyloxy, heterocyclyl, heterocyclylalkyl, heterocyclyloxy and heterocyclylalkoxy groups, carbonyl (oxo), carboxylate, ester, urethane, oxime, hydroxylamine, alkoxyamine, aralkoxyamine, thiol, sulfide, sulfoxide, sulfone, sulfonyl, pentafluorosulfanil (i.e., SF5), sulfonamide, amine, N-oxide, hydrazine, hydrazide, hydrazone, azide, amide, urea, amidine, guanidine, enamine, imide, isocyanate, isothiocyanate, cyanate, thiocyanate, imine, nitro group, and nitrile (i.e., CN).

[0010] Substituted ring groups, such as substituted cycloalkyl, aryl, heterocyclyl, and heteroaryl groups, also include rings and ring systems in which bonds to hydrogen atoms are replaced by bonds to carbon atoms. Therefore, substituted cycloalkyl, aryl, heterocyclyl, and heteroaryl groups may also be substituted with substituted or unsubstituted alkyl, alkenyl, and alkynyl groups as defined below.

[0011] Alkyl groups include linear and branched alkyl groups having 1 to 12 carbon atoms, typically having 1 to 10 carbon atoms, or in some embodiments having 1 to 8, 1 to 6, or 1 to 4 carbon atoms. Alkyl groups may or may not be substituted. Examples of linear alkyl groups include methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, n-heptyl, and n-octyl groups. Examples of branched alkyl groups include, but are not limited to, isopropyl, isobutyl, sec-butyl, tert-butyl, neopentyl, isopentyl, and 2,2-dimethylpropyl groups. Typical substituted alkyl groups may be substituted one or more times with substituents such as those listed above, and include, but are not limited to, haloalkyls (e.g., trifluoromethyl), hydroxyalkyls, thioalkyls, aminoalkyls, alkylaminoalkyls, dialkylaminoalkyls, alkoxyalkyls, and carboxyalkyls.

[0012] Cycloalkyl groups include monocyclic, bicyclic, or tricyclic alkyl groups having 3 to 12 carbon atoms in the ring, and in some embodiments, having 3 to 10, 3 to 8, or 3 to 4, 5, or 6 carbon atoms. Cycloalkyl groups may or may not be substituted. Exemplary monocyclic cycloalkyl groups include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl groups. In some embodiments, cycloalkyl groups have 3 to 8 ring members, and in other embodiments, the number of ring carbon atoms is in the range of 3 to 5, 3 to 6, or 3 to 7. Bicyclic and tricyclic ring systems include, but are not limited to, both cross-linked cycloalkyl groups and fused rings such as bicyclo[2.1.1]hexane, adamantyl, and dekalinyl. Substituted cycloalkyl groups may be substituted one or more times with non-hydrogen and non-carbon groups as defined above. However, substituted cycloalkyl groups also include rings substituted with linear or branched alkyl groups as defined above. Typical substituted cycloalkyl groups may be monosubstituted or substituted more than once. Examples include, but are not limited to, 2,2-, 2,3-, 2,4-, 2,5-, or 2,6-disubstituted cyclohexyl groups, and may be substituted with substituents such as those listed above.

[0013] A cycloalkylalkyl group is an alkyl group as defined above, in which the hydrogen or carbon bonds of the alkyl group are replaced by bonds to the cycloalkyl group as defined above. Cycloalkylalkyl groups may be substituted or unsubstituted. In some embodiments, cycloalkylalkyl groups have 4 to 16 carbon atoms, 4 to 12 carbon atoms, and typically 4 to 10 carbon atoms. A substituted cycloalkylalkyl group may be substituted in the alkyl moiety, the cycloalkyl moiety, or both the alkyl and cycloalkyl moieties of the group. Typical substituted cycloalkylalkyl groups may be monosubstituted or more than once, and may be monosubstituted, disubstituted, or trisubstituted with substituents such as those listed above, for example, but are not limited to these.

[0014] The alkenyl group includes the linear and branched alkyl groups defined above, except that at least one double bond is present between two carbon atoms. The alkenyl group may or may not be substituted. The alkenyl group has 2 to 12 carbon atoms, typically 2 to 10 carbon atoms, or in some embodiments 2 to 8, 2 to 6, or 2 to 4 carbon atoms. In some embodiments, the alkenyl group has 1, 2, or 3 carbon-carbon double bonds. Examples include, but are not limited to, vinyl, allyl, -CH=CH(CH3), -CH=C(CH3)2, -C(CH3)=CH2, -C(CH3)=CH(CH3), -C(CH2CH3)=CH2, etc. Typical substituted alkenyl groups may be monosubstituted or more than once, and may be monosubstituted, disubstituted, or trisubstituted with substituents such as those listed above, for example, but are not limited to these.

[0015] The cycloalkenyl group includes the cycloalkyl group defined above, having at least one double bond between two carbon atoms. The cycloalkenyl group may or may not be substituted. In some embodiments, the cycloalkenyl group may have one, two, or three double bonds, but does not contain aromatic compounds. The cycloalkenyl group has 4 to 14 carbon atoms, or in some embodiments, 5 to 14 carbon atoms, 5 to 10 carbon atoms, and even 5, 6, 7, or 8 carbon atoms. Examples of cycloalkenyl groups include cyclohexenyl, cyclopentenyl, cyclohexadienyl, cyclobutadienyl, and cyclopentadienyl.

[0016] A cycloalkenylalkyl group is an alkyl group as defined above, in which the hydrogen or carbon bond of the alkyl group is replaced by a bond to the cycloalkenyl group as defined above. Cycloalkenylalkyl groups may be substituted or unsubstituted. A substituted cycloalkenylalkyl group may be substituted in the alkyl portion, the cycloalkenyl portion, or both the alkyl and cycloalkenyl portions of the group. Typical substituted cycloalkenylalkyl groups may be substituted one or more times with substituents such as those listed above.

[0017] The term "alkenal" refers to a compound containing at least one alkenyl group and at least one aldehyde group. Alkynyl groups include linear and branched alkyl groups as defined above, except that at least one triple bond exists between two carbon atoms. Alkynyl groups may or may not be substituted. Alkynyl groups have 2 to 12 carbon atoms, typically 2 to 10 carbon atoms, or in some embodiments 2 to 8, 2 to 6, or 2 to 4 carbon atoms. In some embodiments, alkynyl groups have 1, 2, or 3 carbon-carbon triple bonds. Examples include, but are not limited to, -C≡CH, -C≡CCH3, -CH2C≡CCH3, and -C≡CCH2CH(CH2CH3)2. Typical substituted alkynyl groups may be monosubstituted or more than once, and may be monosubstituted, disubstituted, or trisubstituted with substituents such as those listed above, but are not limited to these.

[0018] An aryl group is a cyclic aromatic hydrocarbon that does not contain heteroatoms. In this specification, aryl groups include monocyclic, bicyclic, and tricyclic ring systems. Aryl groups may or may not be substituted. Therefore, examples of aryl groups include, but are not limited to, phenyl, azlenyl, heptarenyl, biphenyl, fluorenyl, phenantrenyl, anthracenyl, indenyl, indanyl, pentarenyl, and naphthyl groups. In some embodiments, the aryl group contains 6 to 14 carbon atoms in its ring portion, and in other embodiments, 6 to 12, and even 6 to 10 carbon atoms. In some embodiments, the aryl group is phenyl or naphthyl. The term "aryl group" includes groups containing fused rings, such as fused aromatic-aliphatic ring systems (e.g., indanyl, tetrahydronaphthyl, etc.). Typical substituted aryl groups may be single-substituted (e.g., tolyl) or more than once substituted. For example, monosubstituted aryl groups include, but are not limited to, 2-, 3-, 4-, 5-, or 6-substituted phenyl groups or naphthyl groups. They may also be substituted with substituents such as those listed above.

[0019] A heteroaryl group is an aromatic ring compound containing five or more ring members, one or more of which are heteroatoms such as N, O, and S, but is not limited to these. The heteroaryl group may be substituted or unsubstituted.

[0020] A heterocyclylalkyl group is an alkyl group as defined above, in which the hydrogen or carbon bond of the alkyl group is replaced by a bond to the heterocyclyl group as defined above.

[0021] Groups described herein that have two or more bonding sites (i.e., divalent, trivalent, or polyvalent) within the compounds of this technology are designated by the use of the suffix "ene". For example, a divalent alkyl group is an alkylene group, a divalent aryl group is an arylene group, a divalent heteroaryl group is a divalent heteroarylene group, and so on. Substituents having a single bonding site to the compounds of this technology are not referred to using the designation "ene". Therefore, for example, chloroethyl is not referred to as chloroethylene herein.

[0022] An alkoxy group is a hydroxyl group (-OH) in which the bond to the hydrogen atom is replaced by a bond to the carbon atom of a substituted or unsubstituted alkyl group as defined above. Alkoxy groups may be substituted or unsubstituted. Examples of linear alkoxy groups include, but are not limited to, methoxy, ethoxy, propoxy, butoxy, pentoxy, and hexoxy. Examples of branched alkoxy groups include, but are not limited to, isopropoxy, sec-butoxy, tert-butoxy, isopentoxy, and isohexoxy. Examples of cycloalkoxy groups include, but are not limited to, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, and cyclohexyloxy. Typical substituted alkoxy groups may be substituted one or more times with substituents such as those listed above.

[0023] As used herein, the term "carboxylate" refers to the -COOH group. As used herein, the term "ester" is -COOR 70 And refers to the -C(O)OG group. 70is a substituted or unsubstituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl, heterocyclylalkyl or heterocyclyl group as defined herein. G is a carboxylate protecting group. Carboxylate protecting groups are well known to those skilled in the art. An extensive list of protecting groups for carboxylate group functionality can be found in Protective Groups in Organic Synthesis, Greene, T.W.; Wuts, P.G.M., John Wiley & Sons, New York, NY, (3rd Ed., 1999), and can be added or removed using the procedures described therein, which document is incorporated herein by reference in its entirety as if fully set forth herein for all purposes.

[0024] The term "amide" (or "amido") refers to C-amide groups and N-amide groups, that is, -C(O)NR 71 R 72 group and -NR 71 C(O)R 72 group. R 71 and R 72 are each independently hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heterocyclylalkyl or heterocyclyl group as defined herein. Accordingly, amide groups include, but are not limited to, carbamoyl groups (-C(O)NH2) and formamide groups (-NHC(O)H). In some embodiments, the amide is -NR 71 C(O)-(C 1-5 alkyl), which group is referred to as "carbonylamino", and in other embodiments, the amide is -NHC(O)-alkyl, which group is referred to as "alkanoylamino".

[0025] As used herein, the term "nitrile" or "cyano" refers to a -CN group. As used herein, the term "amine" (or "amino") refers to -NR 75 R76 It refers to the base, R 75 and R 76 Each is independently hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heterocyclylalkyl, or heterocyclyl group as defined herein. In some embodiments, the amine is an alkylamino, dialkylamino, arylamino, or alkylarylamino. In other embodiments, the amine is NH2, methylamino, dimethylamino, ethylamino, diethylamino, propylamino, isopropylamino, phenylamino, or benzylamino.

[0026] The term "imin" is -CR 100 (NR 101 ) group and -N(CR 100 R 101 ) refers to the base, R 100 and R 101 Each is independently hydrogen or a substituted or unsubstituted alkyl, cycloalkyl, alkenyl, alkynyl, arylaralkyl, heterocyclyl, or heterocyclylalkyl as defined herein, but R 100 and R 101 The condition is that both are not hydrogen at the same time.

[0027] As will be understood by those skilled in the art, for all purposes, and especially in terms of providing descriptive explanations, all scopes disclosed herein also encompass any and all possible subscopes and combinations of subscopes. Any scope enumerated can be readily recognized as sufficiently describing and enabling that the same scope may be divided into at least two, three, four, five, ten, etc. As a non-limiting example, each scope discussed herein can readily be divided into a lower third, a middle third, and an upper third, etc. As will also be understood by those skilled in the art, all language such as “up to,” “at least,” “greater than,” and “less than” includes the enumerated number and refers to a scope that can be divided into subscopes as discussed above. Finally, as will be understood by those skilled in the art, a scope includes each individual component. Thus, for example, a group having 1 to 3 atoms refers to a group having 1, 2, or 3 atoms. Similarly, a group having 1 to 5 atoms refers to a group having 1, 2, 3, 4, or 5 atoms, and so on.

[0028] "C x -C y The phrase "(for example, "C5-C8 alkenal")" is understood to mean that the compound has a total number of carbon atoms that fall within the range of x to y. z +" or "C z The phrase "plus" is understood to include compounds with more than z carbon atoms, and similarly, "C w -" or "C w The term "minus" is understood to include compounds with w or fewer carbon atoms.

[0029] As those skilled in the art will understand, "molecular weight" (also known as "relative molar mass") is a dimensionless quantity, but it can be converted to molar mass by multiplying by 1 gram / mol or 1 Da. For example, a compound with a weight-average molecular weight of 5,000 has a weight-average molar mass of 5,000 g / mol and a weight-average molar mass of 5,000 Da.

[0030] pharmaceutically acceptable salts of the compounds described herein include acid or base addition salts that are within the scope of this technology, retain the desired pharmacological activity, and are not biologically undesirable (e.g., the salt is not excessively toxic, allergenic, or irritating, and is biologically usable). If the compounds of this technology have a basic group such as an amino group, pharmaceutically acceptable salts can be formed with inorganic acids (e.g., hydrochloric acid, boric acid, nitric acid, sulfuric acid, and phosphoric acid), organic acids (e.g., alginic acid, formic acid, acetic acid, benzoic acid, gluconic acid, fumaric acid, oxalic acid, tartaric acid, lactic acid, maleic acid, citric acid, succinic acid, malic acid, methanesulfonic acid, benzenesulfonic acid, naphthalenesulfonic acid, and p-toluenesulfonic acid) or acidic amino acids (e.g., aspartic acid and glutamic acid). If the compounds of this technology have an acidic group such as a carboxylic acid group, alkali metals and alkaline earth metals (e.g., Na) can be added. + Li + , K + Ca 2+ Mg 2+ Zn 2+ These compounds can form salts with metals such as ), ammonia, or organic amines (e.g., dicyclohexylamine, trimethylamine, triethylamine, pyridine, picoline, ethanolamine, diethanolamine, triethanolamine), or basic amino acids (e.g., arginine, lysine, and ornithine). Such salts can be prepared in situ during the isolation and purification of the compound, or by reacting the purified compound separately with appropriate acids or bases in the form of its free base or free acid, and then isolating the salts thus formed.

[0031] Throughout this disclosure, various publications, patents, and published patent specifications are referenced by identifying citations. Within this disclosure, there are Arabic numerals indicating references, the complete bibliographic details of which are provided after the Examples section. These publications, patents, and published patent specifications are incorporated by reference to this disclosure for a more complete description of the Art.

[0032] As used herein, the term “interior space” refers to a finite volume of space in a residential, commercial, or vehicle environment. As used herein, the term “indoor surface” refers to the surface of an object in an indoor space. Such objects include, but are not limited to, walls, ceilings, floors, partitions, windows, doors, trim, rugs, carpets, wall hangings, vents, beds, chairs, toilets, refrigerators, kitchen cabinets, sinks, trash cans, curtains, towels, clothing, vehicle seats, sofas, and furniture.

[0033] As used herein, the term “membrane” refers to a semipermeable material that allows some components of a substance to pass through but blocks others. Of the components that pass through, the membrane regulates the permeation of components; that is, some components pass through faster than others. Such components may include molecules, ions, or particles.

[0034] As used herein, the term “permeable material” refers to any material that allows liquids or gases to pass through, and includes, but is not limited to, gypsum board, wallpaper, wood, vinyl, plastics, plaster, wall coverings, textiles, interior decorating materials, paper, woven fabrics, natural polymers, synthetic polymers and inorganic materials and mixtures thereof. Permeable materials may also include residues formed on their surfaces.

[0035] As used herein, the terms "vaporize" or "vaporization" refer to the phase transition of a substance or compound from a solid phase and / or liquid phase to a gaseous phase.

[0036] [This technology] Microbial growth remains a troublesome problem in many indoor spaces used by people, especially in hot and humid regions. Bleach and other disinfectant products are harsh to use and only kill microorganisms at the time of application; any surviving microorganisms quickly return to perceptible levels. Furthermore, there is a strong consumer demand for products that can inhibit microbial growth and the resulting stains and odors.

[0037] This technology addresses these needs and offers additional advantages by providing compositions and apparatus that enable the continuous or intermittent continuous release of specific antimicrobial compounds. Furthermore, this technology allows such release to occur accompanied by a pleasant associated aroma.

[0038] Accordingly, in one embodiment, the Technology includes a composition for providing an effective microbial inhibitory headspace concentration of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof, the composition comprising allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof, a fragrance, and optionally an emulsifier. For ease of reference, any composition included in any aspect or embodiment of this Specification may be referred to as "the Composition of the Technology," "the Group of Compositions of the Technology," etc., anywhere in this Disclosure.

[0039] "Effective microbial inhibitory headspace concentration" refers to the vapor concentration of a compound in a gas, measured when the gas is at approximately 35°C and approximately 80% relative humidity, which is effective in inhibiting the growth of one or more microorganisms on indoor surfaces. Such microorganisms may be Aspergillus niger, Pseudomonas aeruginosa, and / or Staphylococcus aureus. A specific "headspace" containing the gas is an indoor space such as a small room or small space. Examples of small rooms include, but are not limited to, bathrooms, toilets, and changing rooms. Examples of small spaces include, but are not limited to, garbage storage spaces, toilets, closets, shoe storage furniture, pet litter boxes, pet carriers, and gym lockers. Pet carriers are small, portable boxes, crates, and / or cages used for transporting small animals such as cats, dogs, hamsters, and guinea pigs. The headspace volume in any aspect or embodiment of this specification may range from about 7 liters to about 5660 liters. In any aspect or embodiment disclosed herein, the effective microbial inhibitory headspace concentration is about 1 × 10⁻¹⁶ of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any combination of two or more of these. -5 The concentration may be μg / L to about 10 μg / L. Therefore, in any embodiment or reference disclosed herein, the effective microbial inhibitory headspace concentration of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof is about 1 × 10⁻⁶. -5 μg / L, approximately 2×10 -5 μg / L, approximately 3×10 -5 μg / L, approximately 4×10 -5 μg / L, approximately 5×10 -5 μg / L, approximately 6×10 -5 μg / L, approximately 7×10 -5 μg / L, approximately 8×10 -5μg / L, approximately 9×10 -5 μg / L, approximately 1×10 -4 μg / L, approximately 2×10 -4 μg / L, approximately 3×10 -4 μg / L, approximately 4×10 -4 μg / L, approximately 5×10 -4 μg / L, approximately 6×10 -4 μg / L, approximately 7×10 -4 μg / L, approximately 8×10 -4 μg / L, approximately 9×10 -4 μg / L, approximately 1×10 -3 μg / L, approximately 2×10 -3 μg / L, approximately 3×10 -3 μg / L, approximately 4×10 -3 μg / L, approximately 5×10 -3 μg / L, approximately 6×10 -3 μg / L, approximately 7×10 -3 μg / L, approximately 8×10 -3 μg / L, approximately 9×10 -3 μg / L, approximately 1×10 -2 μg / L, approximately 2×10 -2 μg / L, approximately 3×10 -2 μg / L, approximately 4×10 -2 μg / L, approximately 5×10 -2 μg / L, approximately 6×10 -2 μg / L, approximately 7×10 -2 μg / L, approximately 8×10 -2 μg / L, approximately 9×10 -2μg / L, approximately 0.1 μg / L, approximately 0.2 μg / L, approximately 0.3 μg / L, approximately 0.4 μg / L, approximately 0.5 μg / L, approximately 0.6 μg / L, approximately 0.7 μg / L, approximately 0.8 μg / L, approximately 0.9 μg / L, approximately 1 μg / L, approximately 2 μg / L, approximately 3 μg / L, approximately 4 μg / L, approximately 5 μg / L, approximately 6 μg / L, approximately 7 μg / L, approximately 8 μg / L, approximately 9 μg / L, approximately 10 μg / L, or any range including any two of these values ​​and / or any range between them. As those skilled in the art will understand from this disclosure and will readily implement in consideration of this disclosure, specific effective microbial inhibitory headspace concentrations for specific components (i.e., allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any combination of two or more thereof) may be provided by adjusting the amount of the component in the composition, taking into account variables such as (i) the size of the chamber, (ii) the type of delivery device, (iii) the release rate of the delivery device, and (iv) the size of the storage compartment of the delivery device.

[0040] While not bound by theory, it is believed that the effective microbial inhibitory headspace concentrations of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any combination of two or more of these provided by this technology result in the disruption of microbial enzymes, disruption of microbial metabolic function (e.g., by diffusion through the cell wall), and / or disruption of the integrity of polysaccharides in the microbial cell wall.

[0041] In any embodiment of this specification, the composition of the Art may contain allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof in amounts of about 0.25% to about 25% by weight (based on the total weight of the composition). Therefore, in any embodiment of this specification, the composition of the Art may contain allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof in amounts of about 0.25% by weight, about 0.30% by weight, about 0.35% by weight, about 0.40% by weight, about 0.45% by weight, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, about 0.8% by weight, about 0.9% by weight, about 1.0% by weight, about 1.1% by weight, about 1.2% by weight, about 1. 3% by weight, approximately 1.4% by weight, approximately 1.5% by weight, approximately 1.6% by weight, approximately 1.7% by weight, approximately 1.8% by weight, approximately 1.9% by weight, approximately 2.0% by weight, approximately 2.1% by weight, approximately 2.2% by weight, approximately 2.3% by weight, approximately 2.4% by weight, approximately 2.5% by weight, approximately 2.6% by weight , about 2.7% by weight, about 2.8% by weight, about 2.9% by weight, about 3.0% by weight, about 3.1% by weight, about 3.2% by weight, about 3.3% by weight, about 3.4% by weight, about 3.5% by weight, about 3.6% by weight, about 3.7% by weight, about 3.8% by weight, about 3.9% by weight, about 4. 0% by weight, approximately 4.1% by weight, approximately 4.2% by weight, approximately 4.3% by weight, approximately 4.4% by weight, approximately 4.5% by weight, approximately 4.6% by weight, approximately 4.7% by weight, approximately 4.8% by weight, approximately 4.9% by weight, approximately 5.0% by weight, approximately 5.1% by weight, approximately 5.2% by weight, approximately 5.3% by weight , about 5.4% by weight, about 5.5% by weight, about 5.6% by weight, about 5.7% by weight, about 5.8% by weight, about 5.9% by weight, about 6.0% by weight, about 6.1% by weight, about 6.2% by weight, about 6.3% by weight, about 6.4% by weight, about 6.5% by weight, about 6.6% by weight, about 6. 7% by weight, approximately 6.8% by weight, approximately 6.9% by weight, approximately 7.0% by weight, approximately 7.1% by weight, approximately 7.2% by weight, approximately 7.3% by weight, approximately 7.4% by weight, approximately 7.5% by weight, approximately 7.6% by weight, approximately 7.7% by weight, approximately 7.8% by weight, approximately 7.9% by weight, approximately 8.0% by weight , about 8.1% by weight, about 8.2% by weight, about 8.3% by weight, about 8.4% by weight, about 8.5% by weight, about 8.6% by weight, about 8.7% by weight, about 8.8% by weight, about 8.9% by weight, about 9.0% by weight, about 9.1% by weight, about 9.2% by weight, about 9.3% by weight, about 9.It may contain 4% by weight, approximately 9.5% by weight, approximately 9.6% by weight, approximately 9.7% by weight, approximately 9.8% by weight, approximately 9.9% by weight, approximately 10% by weight, approximately 10.5% by weight, approximately 11% by weight, approximately 11.5% by weight, approximately 12% by weight, approximately 12.5% ​​by weight, approximately 13% by weight, approximately 13.5% by weight, approximately 14% by weight, approximately 14.5% by weight, approximately 15% by weight, approximately 15.5% by weight, approximately 16% by weight, approximately 17% by weight, approximately 18% by weight, approximately 19% by weight, approximately 20% by weight, approximately 21% by weight, approximately 22% by weight, approximately 23% by weight, approximately 24% by weight, approximately 25% by weight, or any two of these values ​​and / or any range between them.

[0042] In any embodiment of this specification, the composition may contain allyl isothiocyanate and optionally substantially omit one or more of citral, thymol, linalool, terpineol, or eugenol. The phrase “substantially omitted” as used in this disclosure is understood to mean that the composition contains less than 0.01% by weight of the indicated component. For example, the composition of this technology may contain allyl isothiocyanate and substantially omit citral. Furthermore, the composition of this technology may contain allyl isothiocyanate and substantially omit one or more of citral, thymol, linalool, terpineol, or eugenol. Therefore, the composition of this technology may contain allyl isothiocyanate and omit citral.

[0043] In any embodiment of this specification, the composition of the Art comprises (a) an unbranched, unsubstituted linear C5-C8 alkenal and (b) an unbranched, unsubstituted linear C9-C 14 The mixture with alkenals may be substantially free of any other components. Furthermore, in any embodiment of this specification, the composition of the Art may include (a) an unbranched, unsubstituted linear C5-C8 alkenal and (b) an unbranched, unsubstituted linear C9-C 14 It does not need to contain a mixture with alkenal.

[0044] In any embodiment of this specification, the composition may contain about 0.25% to about 3.0% by weight of allyl isothiocyanate. Therefore, in any embodiment of this specification, the composition of the Art may contain allyl isothiocyanate in amounts of about 0.25% by weight, about 0.30% by weight, about 0.35% by weight, about 0.40% by weight, about 0.45% by weight, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, about 0.8% by weight, about 0.9% by weight, about 1.0% by weight, about 1.1% by weight, about 1.2% by weight, about 1.3% by weight, about 1.4% by weight, It may contain amounts of approximately 1.5% by weight, approximately 1.6% by weight, approximately 1.7% by weight, approximately 1.8% by weight, approximately 1.9% by weight, approximately 2.0% by weight, approximately 2.1% by weight, approximately 2.2% by weight, approximately 2.3% by weight, approximately 2.4% by weight, approximately 2.5% by weight, approximately 2.6% by weight, approximately 2.7% by weight, approximately 2.8% by weight, approximately 2.9% by weight, approximately 3.0% by weight, or any two of these values ​​and / or any range between them.

[0045] In any embodiment of this specification, the composition may contain about 0.25% to about 8.1% by weight of citral, and therefore, in any embodiment of this specification, the composition of the Art contains citral in amounts of about 0.25% by weight, about 0.30% by weight, about 0.35% by weight, about 0.40% by weight, about 0.45% by weight, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, about 0.8% by weight, about 0.9% by weight, about 1.0% by weight, about 1.1% by weight, and about 1.2% by weight. Weight%, about 1.3% by weight, about 1.4% by weight, about 1.5% by weight, about 1.6% by weight, about 1.7% by weight, about 1.8% by weight, about 1.9% by weight, about 2.0% by weight, about 2.1% by weight, about 2.2% by weight, about 2.3% by weight, about 2.4% by weight, About 2.5% by weight, about 2.6% by weight, about 2.7% by weight, about 2.8% by weight, about 2.9% by weight, about 3.0% by weight, about 3.1% by weight, about 3.2% by weight, about 3.3% by weight, about 3.4% by weight, about 3.5% by weight, about 3.6% by weight, about 3.7 Weight%, about 3.8% by weight, about 3.9% by weight, about 4.0% by weight, about 4.1% by weight, about 4.2% by weight, about 4.3% by weight, about 4.4% by weight, about 4.5% by weight, about 4.6% by weight, about 4.7% by weight, about 4.8% by weight, about 4.9% by weight, Approximately 5.0% by weight, approximately 5.1% by weight, approximately 5.2% by weight, approximately 5.3% by weight, approximately 5.4% by weight, approximately 5.5% by weight, approximately 5.6% by weight, approximately 5.7% by weight, approximately 5.8% by weight, approximately 5.9% by weight, approximately 6.0% by weight, approximately 6.1% by weight, approximately 6.2 This may include amounts of weight%, approximately 6.3% by weight, approximately 6.4% by weight, approximately 6.5% by weight, approximately 6.6% by weight, approximately 6.7% by weight, approximately 6.8% by weight, approximately 6.9% by weight, approximately 7.0% by weight, approximately 7.1% by weight, approximately 7.2% by weight, approximately 7.3% by weight, approximately 7.4% by weight, approximately 7.5% by weight, approximately 7.6% by weight, approximately 7.7% by weight, approximately 7.8% by weight, approximately 7.9% by weight, approximately 8.0% by weight, approximately 8.1% by weight, or any two of these values ​​and / or any range of amounts between them.

[0046] In any embodiment of the Art described herein, the composition may contain about 0.25% to about 3.0% by weight of thymol. Therefore, in any embodiment of the Art described herein, the composition of the Art may contain thymol in amounts of about 0.25% by weight, about 0.30% by weight, about 0.35% by weight, about 0.40% by weight, about 0.45% by weight, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, about 0.8% by weight, about 0.9% by weight, about 1.0% by weight, about 1.1% by weight, about 1.2% by weight, about 1.3% by weight, about 1.4% by weight, and about 1.5% by weight. It may contain amounts of weight%, approximately 1.6% by weight, approximately 1.7% by weight, approximately 1.8% by weight, approximately 1.9% by weight, approximately 2.0% by weight, approximately 2.1% by weight, approximately 2.2% by weight, approximately 2.3% by weight, approximately 2.4% by weight, approximately 2.5% by weight, approximately 2.6% by weight, approximately 2.7% by weight, approximately 2.8% by weight, approximately 2.9% by weight, approximately 3.0% by weight, or any two of these values ​​and / or any range between them.

[0047] In any embodiment of the present technology, the composition may contain about 0.25% to about 20% by weight of linalool. Therefore, in any embodiment of the present technology, the composition of the technology may contain linalool in amounts of about 0.25% by weight, about 0.30% by weight, about 0.35% by weight, about 0.40% by weight, about 0.45% by weight, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, about 0.8% by weight, about 0.9% by weight, about 1.0% by weight, about 1.1% by weight, about 1.2% by weight, about 1.3% by weight, about 1.4% by weight, about 1.5% by weight, about 1.6% by weight, about 1.7% by weight, about 1.8% by weight, about 1.9% by weight, about 2.0% by weight, about 2.1% by weight, about 2.2% by weight, and about 2.3% by weight. Weight %, about 2.4 weight %, about 2.5 weight %, about 2.6 weight %, about 2.7 weight %, about 2.8 weight %, about 2.9 weight %, about 3.0 weight %, about 3.1 weight %, about 3.2 weight %, about 3.3 weight %, about 3.4 weight %, about 3.5 weight %, about 3.6 weight %, about 3.7 weight %, about 3.8% by weight, approximately 3.9% by weight, approximately 4.0% by weight, approximately 4.1% by weight, approximately 4.2% by weight, approximately 4.3% by weight, approximately 4.4% by weight, approximately 4.5% by weight, approximately 4.6% by weight, approximately 4.7% by weight, approximately 4.8% by weight, approximately 4.9% by weight, approximately 5.0% by weight, approximately 5.1% by weight, approximately 5.2% by weight %, about 5.3% by weight, about 5.4% by weight, about 5.5% by weight, about 5.6% by weight, about 5.7% by weight, about 5.8% by weight, about 5.9% by weight, about 6.0% by weight, about 6.1% by weight, about 6.2% by weight, about 6.3% by weight, about 6.4% by weight, about 6.5% by weight, about 6.6% by weight, about 6. 7% by weight, approximately 6.8% by weight, approximately 6.9% by weight, approximately 7.0% by weight, approximately 7.1% by weight, approximately 7.2% by weight, approximately 7.3% by weight, approximately 7.4% by weight, approximately 7.5% by weight, approximately 7.6% by weight, approximately 7.7% by weight, approximately 7.8% by weight, approximately 7.9% by weight, approximately 8.0% by weight, approximately 8.1% by weight, Approximately 8.2% by weight, approximately 8.3% by weight, approximately 8.4% by weight, approximately 8.5% by weight, approximately 8.6% by weight, approximately 8.7% by weight, approximately 8.8% by weight, approximately 8.9% by weight, approximately 9.0% by weight, approximately 9.1% by weight, approximately 9.2% by weight, approximately 9.3% by weight, approximately 9.4% by weight, approximately 9.5% by weight, approximately 9.6% by weight Amount %, about 9.7% by weight, about 9.8% by weight, about 9.9% by weight, about 10% by weight, about 10.5% by weight, about 11% by weight, about 11.5% by weight, about 12% by weight, about 12.5% ​​by weight, about 13% by weight, about 13.5% by weight, about 14% by weight, about 14.5% by weight, about 15% by weight, about 15.It may contain 5% by weight, approximately 16% by weight, approximately 17% by weight, approximately 18% by weight, approximately 19% by weight, approximately 20% by weight, or any two of these values ​​and / or any range in between.

[0048] In any embodiment of this specification, the composition may contain about 0.25% to about 20% by weight of terpineol. Therefore, in any embodiment of this specification, the composition of the Art may contain terpineol in amounts of about 0.25% by weight, about 0.30% by weight, about 0.35% by weight, about 0.40% by weight, about 0.45% by weight, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, about 0.8% by weight, about 0.9% by weight, about 1.0% by weight, about 1.1% by weight, about 1.2% by weight, about 1.3% by weight, about 1.4% by weight, about 1.5% by weight, about 1.6% by weight, about 1.7% by weight, about 1.8% by weight, about 1.9% by weight, about 2.0% by weight, about 2.1% by weight, about 2.2% by weight, and about 2% by weight. .3% by weight, approximately 2.4% by weight, approximately 2.5% by weight, approximately 2.6% by weight, approximately 2.7% by weight, approximately 2.8% by weight, approximately 2.9% by weight, approximately 3.0% by weight, approximately 3.1% by weight, approximately 3.2% by weight, approximately 3.3% by weight, approximately 3.4% by weight, approximately 3.5% by weight, approximately 3.6% by weight, approximately 3.7% by weight , about 3.8% by weight, about 3.9% by weight, about 4.0% by weight, about 4.1% by weight, about 4.2% by weight, about 4.3% by weight, about 4.4% by weight, about 4.5% by weight, about 4.6% by weight, about 4.7% by weight, about 4.8% by weight, about 4.9% by weight, about 5.0% by weight, about 5.1% by weight, about 5.2% by weight Amount %, about 5.3 weight%, about 5.4 weight%, about 5.5 weight%, about 5.6 weight%, about 5.7 weight%, about 5.8 weight%, about 5.9 weight%, about 6.0 weight%, about 6.1 weight%, about 6.2 weight%, about 6.3 weight%, about 6.4 weight%, about 6.5 weight%, about 6.6 weight%, about 6 .7% by weight, approximately 6.8% by weight, approximately 6.9% by weight, approximately 7.0% by weight, approximately 7.1% by weight, approximately 7.2% by weight, approximately 7.3% by weight, approximately 7.4% by weight, approximately 7.5% by weight, approximately 7.6% by weight, approximately 7.7% by weight, approximately 7.8% by weight, approximately 7.9% by weight, approximately 8.0% by weight, approximately 8.1% by weight, Approximately 8.2% by weight, approximately 8.3% by weight, approximately 8.4% by weight, approximately 8.5% by weight, approximately 8.6% by weight, approximately 8.7% by weight, approximately 8.8% by weight, approximately 8.9% by weight, approximately 9.0% by weight, approximately 9.1% by weight, approximately 9.2% by weight, approximately 9.3% by weight, approximately 9.4% by weight, approximately 9.5% by weight, approximately 9.6% by weight Amount %, about 9.7% by weight, about 9.8% by weight, about 9.9% by weight, about 10% by weight, about 10.5% by weight, about 11% by weight, about 11.5% by weight, about 12% by weight, about 12.5% ​​by weight, about 13% by weight, about 13.5% by weight, about 14% by weight, about 14.5% by weight, about 15% by weight, about 15.It may contain 5% by weight, approximately 16% by weight, approximately 17% by weight, approximately 18% by weight, approximately 19% by weight, approximately 20% by weight, or any two of these values ​​and / or any range in between.

[0049] In any embodiment of this specification, the composition may contain about 0.25% to about 25% by weight of eugenol. Therefore, in any embodiment of this specification, the composition of the Art may contain eugenol in amounts of about 0.25% by weight, about 0.30% by weight, about 0.35% by weight, about 0.40% by weight, about 0.45% by weight, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, about 0.8% by weight, about 0.9% by weight, about 1.0% by weight, about 1.1% by weight, about 1.2% by weight, about 1.3% by weight, about 1.4% by weight, about 1.5% by weight, about 1.6% by weight, about 1.7% by weight, about 1.8% by weight, about 1.9% by weight, about 2.0% by weight, about 2.1% by weight, about 2.2% by weight, and about 2. 3% by weight, about 2.4% by weight, about 2.5% by weight, about 2.6% by weight, about 2.7% by weight, about 2.8% by weight, about 2.9% by weight, about 3.0% by weight, about 3.1% by weight, about 3.2% by weight, about 3.3% by weight, about 3.4% by weight, about 3.5% by weight, about 3.6% by weight, about 3.7% by weight, Approximately 3.8% by weight, approximately 3.9% by weight, approximately 4.0% by weight, approximately 4.1% by weight, approximately 4.2% by weight, approximately 4.3% by weight, approximately 4.4% by weight, approximately 4.5% by weight, approximately 4.6% by weight, approximately 4.7% by weight, approximately 4.8% by weight, approximately 4.9% by weight, approximately 5.0% by weight, approximately 5.1% by weight, approximately 5.2% by weight %, about 5.3% by weight, about 5.4% by weight, about 5.5% by weight, about 5.6% by weight, about 5.7% by weight, about 5.8% by weight, about 5.9% by weight, about 6.0% by weight, about 6.1% by weight, about 6.2% by weight, about 6.3% by weight, about 6.4% by weight, about 6.5% by weight, about 6.6% by weight, about 6. 7% by weight, approximately 6.8% by weight, approximately 6.9% by weight, approximately 7.0% by weight, approximately 7.1% by weight, approximately 7.2% by weight, approximately 7.3% by weight, approximately 7.4% by weight, approximately 7.5% by weight, approximately 7.6% by weight, approximately 7.7% by weight, approximately 7.8% by weight, approximately 7.9% by weight, approximately 8.0% by weight, approximately 8.1% by weight, Approximately 8.2% by weight, approximately 8.3% by weight, approximately 8.4% by weight, approximately 8.5% by weight, approximately 8.6% by weight, approximately 8.7% by weight, approximately 8.8% by weight, approximately 8.9% by weight, approximately 9.0% by weight, approximately 9.1% by weight, approximately 9.2% by weight, approximately 9.3% by weight, approximately 9.4% by weight, approximately 9.5% by weight, approximately 9.6% by weight Amount %, about 9.7% by weight, about 9.8% by weight, about 9.9% by weight, about 10% by weight, about 10.5% by weight, about 11% by weight, about 11.5% by weight, about 12% by weight, about 12.5% ​​by weight, about 13% by weight, about 13.5% by weight, about 14% by weight, about 14.5% by weight, about 15% by weight, about 15.It may contain 5% by weight, approximately 16% by weight, approximately 17% by weight, approximately 18% by weight, approximately 19% by weight, approximately 20% by weight, or any two of these values ​​and / or any range in between.

[0050] As disclosed above, the compositions of the Technology include fragrances and optionally include emulsifiers. Suitable fragrances include, but are not limited to, odor-blocking agents, odor-insulating agents, and / or fragrance raw materials. "Odor-blocking" refers to the ability of a compound to dull the human sense of smell. "Odor-blocking" refers to the ability of a compound to block or mask the odor of another compound. Odor-blocking may include compounds having a non-unpleasant or pleasant odor that are administered in such a way as to limit the ability to perceive the odor of another compound. Odor-blocking may involve the selection of compounds that, in harmony with any expected undesirable odor, alter the perception of the overall odor provided by the combination of compounds. The fragrances in any embodiment of this Specified may include, or do not include, allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof. Suitable emulsifiers include, but are not limited to, polyvinylpyrrolidone ("PVP"), sorbitan trioleate, oleic acid, citric acid, polyoxyethylene lauryl ether and / or polyoxyethylene sorbitan monolaurate (e.g., polyoxyethylene (20) sorbitan monolaurate). The emulsifier may be included in an amount of about 0.01% to about 1.0% by weight of the composition, and therefore, in any embodiment of this specification, the composition may include the emulsifier in an amount of about 0.01% by weight, about 0.02% by weight, about 0.03% by weight, about 0.04% by weight, about 0.05% by weight, about 0.06% by weight, about 0.07% by weight, about 0.08% by weight, about 0.09% by weight, about 0.10% by weight, about 0.15% by weight, about 0.20% by weight, about 0.25% by weight, about 0.30% by weight, about 0.35% by weight, about 0.40% by weight, about 0.45% by weight, about 0.5% by weight, about 0.6% by weight, about 0.7% by weight, about 0.8% by weight, about 0.9% by weight, about 1.0% by weight, or any two of these values ​​and / or any range between them.

[0051] A composition according to any embodiment of this specification may further comprise a thickener, a foaming agent, and / or a wetting agent. In any embodiment of this specification, the thickener may comprise carboxymethylcellulose, sodium alginate, carrageenan, and / or xanthan gum. In any embodiment of this specification, the foaming agent may comprise sucrose fatty acid ester, maltose fatty acid ester, and / or sodium lauroyl sarcosinate. In any embodiment of this specification, the wetting agent may comprise glycerol, sorbitol, and / or propylene glycol.

[0052] A composition according to any embodiment of this specification may further contain a diluent. Examples of diluents include, but are not limited to, dipropylene glycol methyl ether and / or 3-methoxy-3-methyl-1-butanol.

[0053] In one embodiment of the present technology, an apparatus is provided comprising a composition according to any embodiment disclosed herein, the apparatus being configured to provide an effective microbial inhibitory headspace concentration of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof. In any embodiment disclosed herein, the apparatus provides about 1 × 10⁻¹⁶ of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof. -5 The apparatus may be configured to provide an effective microbial inhibitory headspace concentration of μg / L to about 10 μg / L, and therefore, in any embodiment disclosed herein, the apparatus provides about 1 × 10⁻¹⁶ μg / L of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof. -5 μg / L, approximately 2×10 -5 μg / L, approximately 3×10 -5 μg / L, approximately 4×10 -5 μg / L, approximately 5×10 -5 μg / L, approximately 6×10-5 μg / L, approximately 7×10 -5 μg / L, approximately 8×10 -5 μg / L, approximately 9×10 -5 μg / L, approximately 1×10 -4 μg / L, approximately 2×10 -4 μg / L, approximately 3×10 -4 μg / L, approximately 4×10 -4 μg / L, approximately 5×10 -4 μg / L, approximately 6×10 -4 μg / L, approximately 7×10 -4 μg / L, approximately 8×10 -4 μg / L, approximately 9×10 -4 μg / L, approximately 1×10 -3 μg / L, approximately 2×10 -3 μg / L, approximately 3×10 -3 μg / L, approximately 4×10 -3 μg / L, approximately 5×10 -3 μg / L, approximately 6×10 -3 μg / L, approximately 7×10 -3 μg / L, approximately 8×10 -3 μg / L, approximately 9×10 -3 μg / L, approximately 1×10 -2 μg / L, approximately 2×10 -2 μg / L, approximately 3×10 -2 μg / L, approximately 4×10 -2 μg / L, approximately 5×10 -2 μg / L, approximately 6×10 -2 μg / L, approximately 7×10 -2 μg / L, approximately 8×10 -2 μg / L, approximately 9×10 -2The device may be configured to provide an effective microbial inhibitory headspace concentration of μg / L, approximately 0.1 μg / L, approximately 0.2 μg / L, approximately 0.3 μg / L, approximately 0.4 μg / L, approximately 0.5 μg / L, approximately 0.6 μg / L, approximately 0.7 μg / L, approximately 0.8 μg / L, approximately 0.9 μg / L, approximately 1 μg / L, approximately 2 μg / L, approximately 3 μg / L, approximately 4 μg / L, approximately 5 μg / L, approximately 6 μg / L, approximately 7 μg / L, approximately 8 μg / L, approximately 9 μg / L, approximately 10 μg / L, or any two of these values ​​and / or any range in between. The device may be, for example, an air fragrance device and may be configured for use in various applications for delivering allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof into the atmosphere. The apparatus in any embodiment of this specification may be non-energized (passive and not requiring power supply from an external energy source such as heat, gas, or electric current) or energized. An exemplary energized apparatus relating to this technology may be an electrical device such as an electric wall plug or a battery-operated air freshener, having a wick and / or membrane as described herein, for transporting and / or vaporizing the allyl isothiocyanate, citral, thymol, linalool, terpineol, and / or eugenol of the composition.

[0054] In any embodiment of this specification, the apparatus may include a reservoir for the composition. The apparatus may also include a delivery member configured to contain the liquid phase of the composition and to vaporize the liquid phase of the composition from there. Suitable delivery members include, but are not limited to, a core, a breathable membrane (e.g., a permeable membrane and / or a semipermeable membrane), a gel, a porous substrate, and / or a felt pad, which may be a semiporous substrate. For example, the delivery member in any embodiment of the Art may be a semipermeable membrane. In any embodiment of this specification including a reservoir for the composition, the apparatus may also include a breakable substrate that is sealedly attached to the reservoir and covers the reservoir to prevent the release of any components of the composition until the apparatus is activated. The breakable substrate may be broken to release allyl isothiocyanate, citral, thymol, linalool, terpineol, and / or eugenol of the composition by activating a breaking mechanism located adjacent to the breakable substrate.

[0055] In any embodiment of this specification that includes a storage section for the composition, the apparatus may include the storage section as part of a container. The container may be made of a material that prevents the gas phase of the composition from diffusing from the apparatus before use, examples of such materials include metal, glass, ceramic and / or plastic. In any embodiment of this specification, the container may contain about 1 mL to about 50 mL of the composition. The container may include a membrane positioned adjacent to the storage section to allow the gas phase of the composition to pass through, and the membrane may be a microporous membrane exhibiting an average pore size of about 0.01 microns to about 0.06 microns, and thus the average pore size may include about 0.01 microns, about 0.02 microns, about 0.03 microns, about 0.04 microns, about 0.05 microns, about 0.06 microns, or any two of these values ​​and / or any range between them.

[0056] In any embodiment of this specification, the membrane may be filled with a suitable filler and / or plasticizer, as will be understood by those skilled in the art (for example, a microporous membrane may contain about 50% to about 80% by weight of silica). Suitable microporous membranes include, but are not limited to, microporous ultra-high molecular weight polyethylene optionally filled with silica, as described in U.S. Patent No. 7,498,369. In any embodiment of this specification, the membrane (e.g., a microporous membrane) may have a thickness of about 0.01 mm to about 1 mm. Accordingly, in any embodiment of the Specified, the film (e.g., a microporous film) may have a thickness of about 0.01 mm, about 0.02 mm, about 0.03 mm, about 0.04 mm, about 0.05 mm, about 0.06 mm, about 0.07 mm, about 0.08 mm, about 0.09 mm, about 0.10 mm, about 0.11 mm, about 0.12 mm, about 0.13 mm, about 0.14 mm, about 0.15 mm, about 0.16 mm, about 0.17 mm, about 0.18 mm, about 0.19 mm, about 0.20 mm, about 0.30 mm, about 0.40 mm, about 0.50 mm, about 0.60 mm, about 0.70 mm, about 0.80 mm, about 0.90 mm, about 1 mm, or any two of these values ​​and / or any range in between. In any embodiment of this specification, the membrane (e.g., a microporous membrane) is approximately 2 cm 2 ~Approx. 100cm 2 The evaporation surface area may include the following. Therefore, in any embodiment of this specification, the evaporation surface area of ​​the film (e.g., a microporous film) is about 2 cm². 2 , about 3cm 2 , about 4cm 2 , about 5cm 2 Approximately 6cm 2 , about 7cm 2 , about 8cm 2 , about 9cm 2 , about 10cm 2 , about 15cm 2 , about 20cm 2 , about 25cm 2, about 30cm 2 , about 35cm 2 , about 40cm 2 Approximately 45cm 2 , about 50cm 2 , about 60cm 2 , about 70cm 2 , about 80cm 2 , about 90cm 2 , about 100cm 2 , or any range including any two of these values ​​and / or any range between them.

[0057] In any embodiment of the Spec., including a core, the core may be composed of various materials and structures, including but not limited to bundled fibers compressed and / or molded into various shapes via overlaps (e.g., nonwoven sheet overlaps), or sintered plastics such as polyethylene. The core may be configured to have various different shapes and sizes (e.g., cylindrical or elongated rectangular parallelepiped shapes). Depending on the shape, the core may be defined by length and diameter or width. In any embodiment, the core may have a length of about 1 mm to about 100 mm. In any embodiment, the core may have a diameter or width of about 1 mm or more. In any embodiment, the core has a weight of about 0.100 grams / cm 3 ~approximately 1 gram / cm³ 3 It may have a density.

[0058] The examples provided herein illustrate the advantages of the Art and are provided to further assist those skilled in the art in preparing or using the compounds and compositions of the Art. The examples provided herein are also presented to more fully illustrate preferred embodiments of the Art. The examples should not be construed as limiting the scope of the Art as defined by the appended claims. The examples may include or incorporate any of the variations, aspects, or embodiments of the Art described above. The variations, aspects, or embodiments described above may also further include or incorporate any or all of the other variations, aspects, or embodiments of the Art. [Examples]

[0059] [Example 1: Simulated bathroom performance of an exemplary composition of this technology] Tests were conducted to evaluate the inhibition of growth of Aspergillus niger, Pseudomonas aeruginosa, and Staphylococcus aureus under conditions designed to simulate actual bathroom conditions. The tested products were (a) a commercially available fragrance composition ("Commercial Fragrance 1"), (b) a commercially available fragrance composition containing trans-2-hexenal ("Commercial Fragrance 2"), (c) Commercial Fragrance 1 further containing 1% by weight of mustard essential oil (the mustard essential oil contains more than 95% by weight of allyl isothiocyanate), and (d) Commercial Fragrance 2 further containing 1% by weight of mustard essential oil (the mustard essential oil contains more than 95% by weight of allyl isothiocyanate). Of these compositions, (a), (c), and (d) were tested against Aspergillus niger, and (a) and (d) were also tested against Pseudomonas erginosa and Staphylococcus aureus, respectively. In addition, (e) Commercial fragrance 2 further containing 3 wt% thymol (as thymol crystals) and (f) Commercial fragrance 2 further containing 8 wt% citral were also tested against Aspergillus niger. Of these compositions, (c) to (f) are the compositions relating to the present technology. For each composition, 8 grams of each composition were placed in the respective test sample cartridge and sealed with metal foil until removed (as shown below).

[0060] For each test composition of Aspergillus niger, Pseudomonas erginosa, and Staphylococcus aureus, two separate 200 ft glass units were used for the toilet and bathtub rooms to simulate actual conditions. 3A test chamber was constructed. Automatic water washing equipment and automatic temperature and humidity control devices were provided. The test room and incubator were set to the required test conditions. The room temperature and relative humidity were maintained at 28±2°C and over 80%, respectively.

[0061] Preparation of the test chamber: The walls and floor of the chamber were cleaned with a 70% isopropyl alcohol solution and dried. The test chamber was set and adjusted to the required test conditions. The temperature and relative humidity in each chamber were maintained at 28±2°C and over 80%, respectively. The frequency of automatic water flushing was set as follows:

[0062] ○Bathtub: Twice a day, only in the morning, at 1-hour intervals (i. Fill with water up to the mark, ii. Keep water in the bathtub, iii. Drain - approximately 20 minutes each time). The shower was operated four times a day, only in the morning, for 5 minutes each time.

[0063] ○Toilet: 8 times a day (4 times in the morning and 4 times in the evening, for 10 seconds at 30-minute intervals). The toilet sink was operated for 30 seconds 4 times a day (2 times in the morning and 2 times in the evening). Glassware: Sterilized glassware was used during the experiment. Appropriate flasks or bottles were used to prepare saline and spore suspensions. The glassware used in this test was washed with commercially available washing solution and dried in a hot air dryer at 60°C for 3 hours. All nutrient media were autoclaved at 121°C and 15 psi for 15 minutes.

[0064] Culture medium: Potato dextrose agar (HIMEDIA-M096), concentration of 39.0 g / liter, final pH 5.6 ± 0.2 at 25°C. The medium was autoclaved at 121°C and 15 psi for 15 minutes and thoroughly mixed before dispensing.

[0065] Preparation of colloidal suspension: Sterile potato dextrose agar plates were prepared in plates or flasks. (Depending on the test) A. niger, P. aeruginosa, or S. aureus was inoculated into the center of the agar plate and incubated at 28±2°C for 7-10 days. A sterile water dilution containing 0.85% sodium chloride and 0.20% Triton X-100 was prepared, and approximately 10 mL of the dilution was poured onto the surface and vigorously stirred to detach the microorganisms. This solution was poured into a sterile beaker and subjected to sonication for 5 minutes to disrupt the microbial chains. The suspension was filtered through sterile cotton wool to remove the microbial chains and any hyphal elements. The conidial suspension was stored at 2-10°C for 4 weeks for use in preparing the test conidial suspensions. Standardization was performed by diluting the stock spore suspension with a saline-surfactant mixture (4 × 10⁻⁶). 6 The procedure was performed using conidial suspensions as needed, by diluting them to contain spores / mL. To prepare the test suspension, 1 mL of a microbial suspension with 5 million conidia / mL was taken and placed in 20 mL of sterile potato dextrose broth (nutrient solution).

[0066] Tile inoculation and culture: The paper and adhesive backings were removed from the ceramic tiles and simply washed with deionized water. The dried tiles were sterilized by UV sterilization, and 50 μL of microbial suspension (approximately 9.7 × 10⁶) was inoculated onto the tiles. 6Spores ( / mL) were inoculated. Four tiles were used for each location, and they were attached to an empty Petri dish using adhesive tape, with some distance between them to avoid dispersion of growth. The Petri dishes with the tiles attached were attached to the walls in different locations. Three sets of tiles were prepared for the incubator, bath room, and toilet room. The tiles were placed in Petri dishes and placed in an incubator set to 35±2°C and over 80% relative humidity for 1 hour for drying. After drying, the plates were moved from the incubator to the adjusted bath room and toilet room, except for one set which was retained in the incubator itself. The temperature and relative humidity inside the chamber and incubator were maintained at 28±2°C and over 80% relative humidity, respectively, for 10 days. The metal foil was then removed from the test sample cartridge and placed facing outwards on the wall of the bath room for 10 days of aging. Ten sets of tiles, each inoculated with either A. niger, P. aeruginosa, or S. aureus, were placed in different locations in a room after aging for 10 days and then maintained under the same conditions for a further 21-day exposure period for comparison.

[0067] Observation: Observations regarding microbial growth were made at the end of the 21-day exposure period. The results of these tests are shown in Table 1 below. The "inhibition rate (%)" was determined in relation to the commercially available fragrance control, and was calculated as "inhibition rate (%)" = [((control inhibition) - (test inhibition)) / (control inhibition)) × 100].

[0068] [Table 1]

[0069] [Example 2: 7L box inhibition by an exemplary composition of this technology] A series of experiments similar to those described in Example 1 were conducted, but the 200ft mentioned was not met. 3 Instead of test chambers, 7L containers made of transparent polypropylene ("7L boxes") were used. Petri dishes inoculated with A. niger, P. aeruginosa, or S. aureus were placed in each 7L box, and the 7L boxes were immediately divided into groups and the following were added:

[0070] (i) As a control, 0.125 grams of commercially available fragrance 1, (ii) 0.125 g of composition of commercial fragrance 2 further comprising 1.2% by weight of mustard essential oil (the mustard essential oil contains more than 95% by weight of allyl isothiocyanate), (iii) 0.125 g of composition of commercial fragrance 2 further containing 3 wt% thymol (as thymol crystals), (iv) 0.125 g of composition of commercial fragrance 2 further comprising 8 wt% citral, (v) 0.125 g of composition of commercial fragrance 2 further comprising 15% by weight of linalool, (vi) 0.125 g of composition of commercial fragrance 2 further comprising 15% by weight of terpineol, (viii) 0.125 grams of a commercially available fragrance composition 2 further comprising 15% by weight of eugenol, or (ix) I didn't put anything extra in the 7L box.

[0071] Subsequently, each 7L box was closed, and the microorganisms in the Petri dishes were allowed to grow for 3 days. Of the above compositions, (ii) to (viii) are the compositions related to this technology. At the end of the 3-day culture period, the growth of the microorganisms was observed. Table 2 below shows the minimum inhibition rate for each test group after the 3-day culture period.

[0072] [Table 2]

[0073] [Example 3: Headspace Concentration Measurement] Another series of experiments ("7L Box Headspace Concentration" experiment) was carried out according to the experiment in Example 2 above, but (i) without including the inoculated Petri dish, and (ii) at the end of the 1-day and 3-day culture periods, the concentrations of the compounds shown in Table 3 below (micrograms per liter (μg / L) of the indicated compounds in the air inside the box at the end of the 1-day or 3-day culture period) were measured by thermal desorption-gas chromatography-mass spectrometry using appropriate calibration, controls, and protocols. Yet another series of experiments ("200ft 3 The "room headspace concentration" experiment was conducted according to the 7L box headspace concentration experiment, but the 200ft discussed in Example 1 3 A test chamber was used, and a 4-week incubation period was employed. Table 3 shows these 200ft 3 The data also includes gas concentration data obtained from room headspace concentration experiments.

[0074] [Table 3]

[0075] As shown in Table 3, the inhibition rate and gas concentration obtained from the 7L box experiment were at 200 ft. 3 These experiments provide data trends that represent the performance of the components in the indoor environment. These experiments also further support that specific effective microbial inhibitory headspace concentrations for specific components can be easily provided by adjusting the amount of the component in the composition, taking into account variables such as (i) room / space size, (ii) room / space ventilation rate, (iii) type of delivery device, (iv) release rate of the delivery device, and (v) size of the storage area of ​​the delivery device.

[0076] [Example 4: Representative composition of this technology] The following compositions (Compositions A to F) of this technology were prepared and found to exhibit microbial inhibition similar to the compositions shown in Table 1 and / or Table 2.

[0077] [Table 4]

[0078] [Table 5]

[0079] [Table 6]

[0080] [Table 7]

[0081] [Table 8]

[0082] [Table 9]

[0083] While specific embodiments have been illustrated and described, those skilled in the art, after reading the foregoing specification, may make modifications, substitutions of equivalents, and other kinds of alterations to the compounds or salts thereof, pharmaceutical compositions, derivatives, prodrugs, metabolites, tautomers, or racemic mixtures of the Art described herein. Each of the embodiments described above may also include or incorporate any such modifications or embodiments disclosed in relation to any or all of the other embodiments.

[0084] This technology should not be limited to specific embodiments described herein, which are intended merely as examples of individual aspects of this technology. Many modifications and variations of this technology can be made without departing from its spirit and scope, as will be apparent to those skilled in the art. In addition to those enumerated herein, functionally equivalent methods within the scope of this technology will be apparent to those skilled in the art from the foregoing description. Such modifications and variations are intended to be included within the scope of the appended claims. It should be understood that this technology is not limited to specific methods, reagents, compounds, compositions, labeled compounds, or biological systems, and these are naturally subject to change. It should also be understood that the terms used herein are for the purpose of describing specific embodiments only and are not intended to be limiting. Accordingly, this specification should be considered illustrative only, and the breadth, scope, and spirit of this technology are intended to be indicated solely by the appended claims, the definitions therein, and their equivalents.

[0085] Embodiments described herein as exemplary may be properly implemented in the absence of any or any elements, limitations, or restrictions not specifically disclosed herein. Therefore, terms such as “comprising,” “including,” and “containing” should be read broadly and without limitation. Furthermore, the terms and expressions used herein are for illustrative purposes only, not limitation, and the use of such terms and expressions is not intended to exclude any equivalents of the exhibited or described features or parts thereof, although it should be recognized that various modifications are possible within the scope of the claimed technology. Furthermore, the phrase “essentially consisting of” should be understood to include the specifically enumerated elements and additional elements that do not substantially affect the basic and novel features of the claimed technology. The phrase “essentially consisting of” excludes any elements not specified.

[0086] Furthermore, where any feature or aspect of this disclosure is described in terms of the Markush group, those skilled in the art will recognize that this disclosure is also described in terms of any individual member or subgroup of any member of the Markush group. Each of the narrower species and subgeneric groups included within the scope of the comprehensive disclosure also forms part of the invention. This includes comprehensive descriptions of the invention with conditions or negative limitations that remove any subject matter from a genus, regardless of whether the excluded materials are specifically described herein.

[0087] As will be understood by those skilled in the art, for all purposes, and especially in terms of providing descriptive explanations, all scopes disclosed herein also encompass any and all possible subscopes and combinations of subscopes. Any scope enumerated can be readily recognized as sufficiently describing and enabling that the same scope may be divided into at least two, three, four, five, ten, etc. As a non-limiting example, each scope discussed herein can readily be divided into a lower third, a middle third, and an upper third, etc. As will also be understood by those skilled in the art, all language such as “up to,” “at least,” “greater than,” and “less than” includes the enumerated numbers and refers to scopes that can be divided into subscopes as discussed above. Finally, as will be understood by those skilled in the art, a scope includes each individual member.

[0088] All publications, patent applications, issued patents, and other documents referenced herein (e.g., academic journals, articles, and / or textbooks) are incorporated herein by reference as if each individual publication, patent application, issued patent, or other document were specifically and individually indicated to be incorporated by reference in whole. Definitions contained in the documents incorporated by reference are excluded to the extent that they conflict with the definitions in this disclosure.

[0089] The technology may include, but is not limited to, the features and combinations of features listed in the following paragraphs, and it should be understood that the following paragraphs should not be construed as limiting the scope of the claims appended to this specification or as requiring that all such features necessarily be included in such claims.

[0090] A. A composition for providing an effective microbial inhibitory headspace concentration of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof, the composition comprising allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof, a fragrance, and optionally an emulsifier.

[0091] B. The effective microbial inhibitory headspace concentration is approximately 1 × 10⁻¹⁰ of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any combination of two or more of these. -5 The composition described in paragraph A, having a concentration of μg / L to approximately 10 μg / L.

[0092] C. The composition according to paragraph A or B, wherein the composition contains about 0.25% to about 25% by weight of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof.

[0093] D. The composition according to any one of paragraphs A to C, wherein the composition comprises about 0.25% to about 3% by weight of allyl isothiocyanate, about 0.25% to about 8.1% by weight of citral, about 0.25% to about 3% by weight of thymol, about 0.25% to about 20% by weight of linalool, about 0.25% to about 20% by weight of terpineol, about 0.25% to about 25% by weight of eugenol, or any two or more combinations thereof.

[0094] E. The composition according to any one of paragraphs A to D, wherein the composition comprises allyl isothiocyanate, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof.

[0095] F. The composition according to any one of paragraphs A to E, wherein the composition comprises allyl isothiocyanate. G. The composition according to any one of paragraphs A to F, wherein the composition comprises about 1% to about 1.5% by weight of allyl isothiocyanate.

[0096] H. The composition described in any one of paragraphs A to G, wherein the composition does not contain citral. I. An apparatus comprising a storage section for containing a composition relating to any one of paragraphs A to H, wherein the apparatus is configured to provide an effective microbial inhibitory headspace concentration of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof.

[0097] J. The apparatus contains approximately 1 × 10⁻¹⁰ of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof. -5 The apparatus described in paragraph I, configured to provide an effective microbial inhibitory headspace concentration of μg / L to approximately 10 μg / L.

[0098] K. The device described in paragraph I or J, which is not energized. L. The device described in any one of paragraphs I to K, wherein the device is an air fragrance device. M. The apparatus according to any one of paragraphs I to L, wherein the apparatus comprises a delivery member configured to contain the liquid phase of the composition and to vaporize the liquid phase of the composition from there.

[0099] N. The apparatus according to any one of paragraphs I to M, wherein the apparatus comprises a container, and the container includes a storage section. O. The apparatus according to any one of paragraphs I to N, wherein the container comprises a membrane positioned adjacent to the storage section for allowing the gas phase of the composition to pass through.

[0100] P. The apparatus according to paragraph O, wherein the film includes a microporous film having an average pore size of approximately 0.01 to approximately 0.06 microns. Q. The apparatus according to paragraph O or P, wherein the membrane is filled with an appropriate filler and / or plasticizer.

[0101] R. The apparatus according to any one of paragraphs O to Q, wherein the film has a thickness of approximately 0.01 mm to approximately 1 mm. S. The membrane is approximately 2 cm 2 ~Approx. 100cm 2 An apparatus having an evaporation surface area as described in any one of paragraphs O to R.

[0102] T. The apparatus described in any one of paragraphs I to S, wherein the delivery member comprises a core. Other embodiments are described in the following claims, along with the entire scope of equivalents to which such claims are entitled.

Claims

1. A composition for providing an effective microbial inhibitory headspace concentration of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof, wherein the composition is Allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any combination of two or more of these, Fragrances and, Optionally, an emulsifier and A composition containing the following:

2. The effective microbial inhibitory headspace concentration is approximately 1 × 10⁻¹⁶ of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any combination of two or more of these. －５ The composition according to claim 1, wherein the concentration is μg / L to about 10 μg / L.

3. The composition according to claim 1, wherein the composition comprises about 0.25% to about 25% by weight of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any combination of two or more thereof.

4. The composition is Approximately 0.25% to 3% by weight of allyl isothiocyanate, Approximately 0.25% to 8.1% by weight of citral, Approximately 0.25% to 3% by weight of thymol, Approximately 0.25% to 20% by weight of linalool, Approximately 0.25% to 20% by weight of terpineol, Approximately 0.25% to approximately 25% by weight of eugenol, or Any two or more combination of those The composition according to claim 1, comprising:

5. The composition according to claim 1, wherein the composition comprises allyl isothiocyanate, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof.

6. The composition according to claim 1, wherein the composition comprises allyl isothiocyanate.

7. The composition according to claim 1, wherein the composition comprises about 1% by weight to about 1.5% by weight of allyl isothiocyanate.

8. The composition according to claim 1, wherein the composition does not contain citral.

9. An apparatus comprising a storage section for containing the composition described in claim 1, The apparatus is configured to provide an effective microbial inhibitory headspace concentration of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof.

10. The apparatus contains approximately 1 × 10⁻¹⁶ of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or any two or more combinations thereof. －５ The apparatus according to claim 9, configured to provide an effective microbial inhibitory headspace concentration of μg / L to about 10 μg / L.

11. The apparatus according to claim 9, wherein the apparatus is non-energized.

12. The apparatus according to claim 9, wherein the apparatus is an air fragrance device.

13. The apparatus according to claim 9, wherein the apparatus comprises a delivery member configured to contain the liquid phase of the composition and to vaporize the liquid phase of the composition from the liquid phase.

14. The apparatus according to claim 9, wherein the apparatus comprises a container, and the container includes the storage section.

15. The apparatus according to claim 9, wherein the container comprises a membrane disposed adjacent to the storage portion for allowing the gas phase of the composition to pass through.

16. The apparatus according to claim 15, wherein the film comprises a microporous film having an average pore size of about 0.01 to about 0.06 microns.

17. The apparatus according to claim 15, wherein the membrane is filled with a suitable filler and / or plasticizer.

18. The apparatus according to claim 15, wherein the film has a thickness of about 0.01 millimeters to about 1 millimeter.

19. The aforementioned film is approximately 2 cm ２ ~Approx. 100cm ２ The apparatus according to claim 15, having an evaporation surface area.

20. The apparatus according to claim 9, wherein the delivery member comprises a core.

Images