Methods for therapeutic targeting of cancer genes using exosomes

JP7599698B2Active Publication Date: 2024-12-16BOARD OF RGT THE UNIV OF TEXAS SYST
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Patent Information

Application Number
JP2020555137
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2018-04-09
Filing Date
2019-04-09
Publication Date
2024-12-16
Estimated Expiration
2039-04-09

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Abstract

The present specification provides a lipid-based nanoparticle composition such as exosome, which comprises a therapeutic substance that inhibits the activity of oncogene.Also provided is a method for using such composition to treat patients with cancer caused by the activation of oncogene.In particular, exosomes containing siRNA that targets oncogenic Myc are provided, along with a method for using the exosomes in cancer treatment.
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Citation Information

Patent Citations

  • Method and composition for the specific inhibition of MYC by double-stranded RNA

    JP2015529467A

  • Methods and compositions for treating cancer

    JP2016520056A

  • Use of cytoplasmic c-MYC for regulating immune responses

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  • Nanoliposomal c-MYC-siRNA Inhibits In Vivo Tumor Growth of Cisplatin-Resistant Ovarian Cancer

    US20150306036A1

  • Use of exosomes for the treatment of disease

    WO2016201323A1