Methods and compositions for delivering antigen-binding fragments of antibodies to the brain - Patents.com

JP7600101B2Active Publication Date: 2024-12-16KAWASAKI INST OF IND PROMOTION
View PDF 2 Cites 0 Cited by

Patent Information

Application Number
JP2021516242
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2019-04-26
Filing Date
2020-04-24
Publication Date
2024-12-16
Estimated Expiration
2040-04-24

AI Technical Summary

Technical Problem

Delivering antibodies across the blood-brain barrier (BBB) for treating neurodegenerative diseases like Alzheimer's and Parkinson's is challenging due to the barrier's selective permeability, and existing methods face complexity and low brain accumulation efficiency.

Method used

Formation of micelles with glucose-coated polycations and negatively charged antigen-binding fragments of antibodies, which are stable in solution and serum, allowing them to cross the BBB and deliver therapeutic fragments to the brain parenchyma.

Benefits of technology

The micelles effectively accumulate in the brain, achieving high delivery efficiency and inhibiting Aβ aggregate formation, providing a potential therapeutic approach for neurodegenerative diseases.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 0007600101000008
    Figure 0007600101000008
  • Figure 0007600101000009
    Figure 0007600101000009
  • Figure 0007600101000010
    Figure 0007600101000010
Patent Text Reader

Abstract

The present invention provides a method and a composition for delivering an antibody or an antigen-binding fragment thereof to the brain. Provided are: a micelle that comprises an antibody or an antigen-binding fragment thereof, said antibody binding to citraconic anhydride and being negatively charged, and a block copolymer of polyethylene glycol with a polycation, wherein at least a part of the block copolymer is bonded to GLUT1 such as glucose at the end on the polyethylene glycol side; and a composition that comprises the micelle.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Protein electrical charge regulator and polymeric micelle complex having a protein encapsulated therein

    WO2010106700A1

  • Carrier for drug delivery and conjugate, composition containing same, and method for administering same

    WO2015075942A1