Compositions and methods involving engineered chimeric antigen receptors and modulators of CARs

JP7602475B2Active Publication Date: 2024-12-18AUTOLUS LIMIED
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Patent Information

Application Number
JP2021552866
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2019-11-05
Filing Date
2020-03-06
Publication Date
2024-12-18
Estimated Expiration
2040-03-06

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Abstract

Provided is a method for producing a cell composition, comprising transducing a population of cells with a mixture of at least two viral vectors, wherein at least one vector comprises a nucleic acid sequence encoding a chimeric antigen receptor (CAR); and wherein at least one vector comprises a nucleic acid encoding an activity modulator that regulates the activity of the CAR, a cell expressing the CAR, or a target cell. Also provided is a cell composition produced by such a method and its use in treating diseases such as cancer.
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Citation Information

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