Recombinant bacteria and methods of use thereof
JP7650808B2Active Publication Date: 2025-03-25NATIONAL UNIVERSITY OF SINGAPORE
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Patent Information
- Application Number
- JP2021550152
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2019-02-28
- Filing Date
- 2020-02-28
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2040-02-28
Abstract
The present disclosure provides a recombinant probiotic lactic acid bacterium, which comprises a non-replicating plasmid vector comprising (a) a tumor suppressor gene or an anti-inflammatory gene operably linked to a first promoter directing the expression of the gene in a mammalian cell, and (b) an adhesin gene operably linked to a second promoter directing the expression of the adhesin gene in the bacterium. The present disclosure also provides uses of the recombinant bacterium and methods for constructing the recombinant bacterium. The present disclosure also provides a method for treating cancer in a subject, the method comprising administering a pharmaceutically effective amount of a recombinant probiotic lactic acid bacterium, wherein the bacterium comprises a non-replicating plasmid vector comprising the adhesin gene operably linked to a promoter directing the expression of the adhesin gene in the bacterium. TIFF2022522295000015.tif83163
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Citation Information
Patent Citations
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