Method for lengthening telomeres in cells
JP7653146B2Active Publication Date: 2025-03-28STEMON INC
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Patent Information
- Application Number
- JP2021516657
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2019-09-03
- Filing Date
- 2019-09-10
- Publication Date
- 2025-03-28
- Estimated Expiration
- 2039-09-10
AI Technical Summary
Benefits of technology
【0025】 本発明の一実施形態による細胞のテロメアを伸長させる方法は、前述の従来のテロメアを伸長させる方法に比べて、簡単であり、コスト面で優れている。すなわち、従来の方法は、化合物を投与する方式であり、この化合物を化学的または生物学的方法を用いて合成および精製する過程、ならびにこのための設備および継続的に投入される材料が必要である。化学合成の場合、特異性がなく、環境に有害であり、このような欠点を生合成により克服することができるが、生合成の場合、収率が低く、大量生産および品質保持が困難であり、汚染の可能性が高いため、それに対処するための設備と材料がさらに必要である。また、細胞は二重脂質膜に囲まれているため、精製された化合物の化学的性質によっては、このような化合物を細胞内に送達できる伝達体がさらに必要であり、この場合、伝達体に化合物をロードする段階が必要とされる。これに対し、本発明の一実施形態による細胞のテロメアを伸長させる方法は、細胞への物理的刺激を直接処理することで効果を奏するので、合成、精製、伝達体考案·合成·調達などの過程をすべて省略することができ、刺激を与えることができる設備があれば実施が可能なので、低コストでテロメアを伸長させることができる。
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Abstract
The present invention discloses a method for extending telomeres in cells, the method comprising the steps of directly or indirectly providing a physical stimulus to cells and culturing a mixture of the cells and culture medium for a certain period of time, wherein the direct provision of the stimulus refers to applying the physical stimulus to a culture medium containing cells, and the indirect provision of the stimulus refers to applying the physical stimulus to a culture medium not containing cells and then mixing the culture medium with the cells. The present invention also discloses cells whose telomeres have been extended by the physical stimulus. The present invention also discloses a method for extending telomeres in cells, the method comprising the steps of directly or indirectly providing a physical stimulus to cells and culturing a mixture of the cells and culture medium for a certain period of time, wherein the direct provision of the stimulus refers to applying the physical stimulus to a culture medium containing cells, and the indirect provision of the stimulus refers to applying the physical stimulus to a culture medium not containing cells and then mixing the culture medium with the cells. The present invention also discloses cells whose telomeres have been extended by the physical stimulus. The present invention also discloses a method for extending telomeres in cells, the method comprising the steps of directly or indirectly providing a physical stimulus to cells and culturing a mixture of the cells and culture medium for a certain period of time, wherein the direct provision of the stimulus refers to applying the physical stimulus to a culture medium containing cells, and then mixing the culture medium with the cells. The present invention also discloses cells whose telomeres have been extended by the physical stimulus. The present invention also discloses a method for extending telomeres in cells, the method comprising the steps of directly or indirectly providing a physical stimulus to cells containing cells and culturing a mixture of the cells and culture medium for a certain period of time, wherein the direct provision of the stimulus refers to applying the physical stimulus to a culture medium not containing cells, and then mixing the culture medium with the cells. The present invention also discloses a method for extending telomeres in cells, the method comprising the steps of directly or indirectly providing a physical stimulus to cells containing cells and culturing the mixture of the cells and culture medium for a certain period of time, wherein the indirect provision of the stimulus refers to applying the physical stimulus to a culture medium not containing cells and then [Selected Figure] Figure 1
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