Pyrrolobenzodiazepine dimer precursor and its ligand-linker conjugate compound

JP7664680B2Active Publication Date: 2025-04-18RIGACHEM BIOSCIENCES INC
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Patent Information

Application Number
JP2019515212
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2018-03-29
Filing Date
2018-03-29
Publication Date
2025-04-18
Estimated Expiration
2038-03-29

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Abstract

The present invention relates to pyrrolobenzodiazepine precursors and their ligand-linker conjugate compounds, compositions containing them, and their therapeutic use, particularly as anticancer agents. The present invention is industrially useful in that the compounds themselves are very stable, have excellent stability in plasma, and are advantageous in terms of toxicity, making it possible to target proliferative diseases such as cancer, perform specific treatment, maximize medical effects, and minimize the occurrence of side effects. [Selected Figure] Figure 1
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Citation Information

Patent Citations

  • Pyrrolobenzodiazepines and their conjugates

    JP2013523895A

  • Pyrrolobenzodiazepines and their complexes

    JP2016539915A

  • KR1,059,183

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  • KR1,700,460