Chimeric antigen receptors targeting sialyl lewis a and uses thereof
JP7672340B2Active Publication Date: 2025-05-07MEMORIAL SLOAN KETTERING CANCER CENT +1
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Patent Information
- Application Number
- JP2021547039
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2018-10-19
- Filing Date
- 2019-10-18
- Publication Date
- 2025-05-07
- Estimated Expiration
- 2039-10-18
Abstract
The presently disclosed subject matter provides methods and compositions for treating cancer (e.g., pancratic cancer). The presently disclosed subject matter relates to antigen-recognizing receptors (e.g., chimeric antigen receptors (CARs)) that specifically target sialyl Lewis A (e.g., human sialyl Lewis A) and immunoresponsive cells comprising such CARs. The presently disclosed sialyl Lewis A-specific CARs have enhanced immune activation properties, including anti-tumor activity. The presently disclosed subject matter provides methods and compositions for treating cancer (e.g., pancreatic cancer).
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Citation Information
Patent Citations
Nucleic acid encoding a human antibody against sialyl-Lewis a
JP2016534735A
Treatment of cancer using chimeric antigen receptors
JP2017513818A