Growth hormone fusion proteins and methods for their preparation and use

JP7681684B2Active Publication Date: 2025-05-22JHM BIOPHARMACEUTICAL (HANGZHOU) CO LTD
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Patent Information

Application Number
JP2023515840
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2021-12-30
Filing Date
2022-04-28
Publication Date
2025-05-22
Estimated Expiration
2042-04-28

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Abstract

The present invention relates to a growth hormone fusion protein and its preparation and use, and according to an embodiment of the present invention, the growth hormone fusion protein comprises a double-chain structure having a first constant region Fc segment and a second constant region Fc segment, and a growth hormone linked to the first constant region Fc segment of the double-chain structure, the growth hormone does not have a methionine at its N-terminus, and the growth hormone fusion protein is expressed by a non-mammalian cell expression system. According to an embodiment of the present invention, by fusing the growth hormone with the double-chain structure, the half-life of the growth hormone in the body can be extended, and since each double-chain structure carries only one growth hormone, the active site of the growth hormone is not affected by steric hindrance, so that the activity of the growth hormone is stronger, and since the growth hormone does not have a methionine at its N-terminus, it is safer.
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Citation Information

Patent Citations

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  • Recombinant human growth hormone Fc fusion protein, application and engineering cell strain of fusion protein

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