Complex of factor VIII having XTEN and von Willebrand factor protein, and its use

A chimeric protein combining a VWF fragment, an XTEN sequence, and FVIII addresses the short half-life of current FVIII products, achieving a substantial extension of FVIII half-life and reducing administration frequency.

JP7682968B2Active Publication Date: 2025-05-26BIOVERATIV THERAPEUTICS INC
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Patent Information

Application Number
JP2023171467
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2013-06-28
Filing Date
2023-10-02
Publication Date
2025-05-26
Estimated Expiration
2033-07-10

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Abstract

To provide Factor VIII complex comprising XTEN and von Willebrand factor protein and uses thereof.SOLUTION: The invention discloses a chimeric protein comprising a VWF protein with D' domain and D3 domain of VWF, at least one XTEN sequence and a FVIII protein, where the VWF fragment, the XTEN sequence or the FVIII protein are linked or associated with each other. The chimeric protein may comprise further one or more Ig constant region or a part thereof (e.g., Fc region).SELECTED DRAWING: None
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Citation Information

Patent Citations

  • Polymer-von Willebrand factor conjugate

    JP2008525491A

  • Factor VIII, von Willebrand factor, or their complexes having an extended in vivo half-life

    JP2011525363A

  • Growth hormone polypeptides and methods of making and using same

    WO2010144502A2

  • Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof

    WO2011069164A2