Monoclonal antibody against LAG-3, antigen-binding fragment thereof, and use thereof

Abstract

The present invention relates to the field of biomedical technology, specifically to an anti-LAG-3 monoclonal antibody, an antigen-binding fragment thereof, and uses thereof, which comprise a heavy chain variable region and a light chain variable region, and the monoclonal antibody or antigen-binding fragment thereof is any one selected from A-1, A-2, A-3, and A-4. The provided monoclonal antibody can specifically bind to LAG-3, has high affinity, and has excellent biological activity, and can be used to treat multiple types of cancers or immune diseases, including leukemia, lung cancer, gastric cancer, esophageal cancer, ovarian cancer, head and neck cancer, melanoma, renal cancer, breast cancer, colorectal cancer, liver cancer, pancreatic cancer, and bladder cancer, and immune diseases including psoriasis, Crohn's disease, rheumatoid arthritis, primary biliary cirrhosis, systemic lupus erythematosus, multiple sclerosis, ulcerative colitis, and autoimmune hepatitis.

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