Methods and compositions for the inhibition of dihydroorotate dehydrogenase in combination with anti-CD38 therapeutic agents

JP7736275B2Active Publication Date: 2025-09-09OHIO STATE INNOVATION FOUND +1
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Patent Information

Application Number
JP2022538731
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2019-12-26
Filing Date
2020-12-26
Publication Date
2025-09-09
Estimated Expiration
2040-12-26
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Abstract

Disclosed are pharmaceutical combinations and methods for treating clinical conditions, such as AML, by administering to a subject a pharmaceutical combination comprising a DHODH inhibitor and an anti-CD38 therapeutic agent, such as an anti-CD38 antibody.The pharmaceutical combination can further comprise one or more additional therapeutic agents.This summary is intended as a scanning tool for searching within a particular technical field and is not intended to limit the disclosure.
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Citation Information

Patent Citations

  • Antibodies against cd38 for treatment of multiple myeloma

    JP2008533977A

  • Treatments for a hematological malignancy

    WO2019027973A1